marksans pharma limited investor presentation february 2008
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Marksans Pharma LimitedInvestor Presentation
February 2008
2
Disclaimer Materials and information provided during this presentation may contain ‘forward-looking
statements’. These statements are based on current expectations, forecasts and assumptions that are subject to risks and uncertainties which could cause actual outcomes and results to differ materially from these statements.
Risks and uncertainties include general industry and market conditions, and general domestic and international economic conditions such as interest rate and currency exchange fluctuations. Risks and uncertainties particularly apply with respect to product-related forward-looking statements. Product risks and uncertainties include, but are not limited, to technological advances and patents attained by competitors, challenges inherent in new product development, including completion of clinical trials; claims and concerns about product safety and efficacy; obtaining regulatory approvals; domestic and foreign healthcare reforms; trends toward managed care and healthcare cost containment, and governmental laws and regulations affecting domestic and foreign operations.
Also, for products that are approved, there are manufacturing and marketing risks and uncertainties, which include, but are not limited, to inability to build production capacity to meet demand, unavailability of raw materials, and failure to gain market acceptance.
The Company undertakes no obligation to update or revise any forward-looking statements whether as a result of new information, future events or otherwise.
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Contents
Section 1 Highlights
Section 2 Industry Overview
Section 3 Company Overview
Section 4 Strategy
Section 5 Financial Highlights
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Highlights
Mumbai based vertically integrated player with strong presence across the entire value chain - APIs to formulations to biopharmaceuticals
Incorporated in 2001 as a wholly owned subsidiary of Glenmark Pharmaceuticals Ltd. and later spun-off into a separate entity in March 2003
Straddles across key therapy areas and markets its products in both evolving and developed markets
Actively engaged in R&D and offers CRAMS to global pharmaceutical companies
Operates world class manufacturing facilities for API and Formulations, built per US FDA guidelines and approved by UK MHRA, Australia TGA and Brazilian ANVISA health authorities
Reported sales of USD 63.4 million and net profit of USD 1.75 million in FY2007
INDUSTRY OVERVIEW
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The Global Pharmaceutical MarketWorldwide pharmaceutical market expected to grow at 5-6% to USD 665-685 billion in 2007
Moderate growth in the US and EU markets
Asia and Latin America are growth drivers
Expiry of patent protection driving Generics market – In 2008, products with sale value of more than USD 20 billion are likely to lose patent protection
Global Pharmaceutical Sales by Region 2006
Market2006 Sales
(USD billion)% Growth
North America 289.90 8.00%
Europe 181.80 4.80%
Japan 56.70 -0.70%
Asia, Africa & Australia 52.00 9.80%
Latin America 27.50 12.90%
Total IMS Audited 607.90 6.50%
Source: IMS Health
Audited World Therapy ClassSales (USD
billion)Y-o-Y
Growth (%)
Lipid Regulators 32.5 7.5Oncologics 34.6 20.5Respiratory Agents 24.6 10.4Acid Pump Inhibitors 24.1 3.9Antidiabetics 21.2 13.1Antidepressants 20.6 3.3Antipsychotics 18.2 10.9Angiotensin-II Antagonists 16.5 15.2Erythropoietin Products 13.9 11.8Anti-epileptics 13.1 10.8Total Leading Therapy Classes 184.3 10.7
Leading Therapy Classes by Global Sales, 2006
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Indian Pharmaceutical Market
Source: www.indiahealth.com
Bulk-drug22%
Formulations78%
India Pharmaceuticals Market 2007
10.4 11.3 12.3 12.414.4
15.6
0
5
10
15
20
2007 2008 2009 2010 2011 2012
Projected Indian Pharmaceutical Market, 2007-2012 (USD Billion)
Source: Espicom
India is one of the fastest growing large pharmaceuticals market
India is also the world’s fourth largest producers of pharmaceuticals by volumes
Competitive Advantage:
Upfront capital cost lower by 25-30%
Clinical trials cost 50% less
Drug production cost lower by 40-50%
Contract Research & Contract Manufacturing (CRAMS)
India has emerged as a key destination for CRAMS
Global manufacturing outsourcing opportunity is estimated at USD 20 billion
Formulations constitute about 78% of total sales. 32% of formulation sales are exports
COMPANY OVERVIEW
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Marksans Pharma Limited
Marksans Pharma Limited is a niche Formulations, Bulk drugs and Biopharmaceutical player with presence across the entire value chain
Incorporated in 2001 as a wholly owned subsidiary of Glenmark Pharmaceuticals Ltd. and later spun-off into a separate entity in March 2003
The Company straddles across key therapy areas and actively engages in R&D and offers CRAMS to global pharmaceutical companies
The Company is listed on The Bombay Stock Exchange and the National Stock Exchange of India Limited with a market capitalisation of Rs 9.24 billion (USD 234 million) as of 8 February 2008
The Company has an employee strength of 1296 out of which more than 100 are engaged in R&D
Reported sales of Rs 2,399 million (USD 60.7 million) and net profit of Rs 69.3 million (USD 1.75 million) in FY2007
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Business Overview
DOMESTIC MARKET
Niche FocusLarge Product portfolio
NDDS, NCEIn-licensing
API Manufacturing
BIOLOGICS Marketing
FORMULATIONSPharmaceuticals + Biologics
EXPORT MARKET
Supply tie-ups Joint marketing
CRAMS Out-licensing
ANDA Filings And Dossier Development
DMF/COS Filings and Dossier Development
Clinical Trials
Custom Chemical Synthesis
Formulation Development & NDDS
Drug Discovery & Development Services
A Complete R&D Player
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Business Segments
1036
1619
13631355
0
400
800
1200
1600
2000
FY2006 FY2007
Bulk Drugs Formulation
28.2
203182
216
0
50
100
150
200
250
300
FY2006 FY2007
Bulk Drugs Formulation
FORMULATION
Significant presence in major therapeutic areas in the domestic market with over 250 products
Strong marketing capabilities with 450 representatives across India
Foreign markets: US, EU, UK, Australia, and other emerging markets. Plans in place to tap huge Russian and CIS markets
Collaborations: MPL’s products are available through collaborations with big MNC companies
ANDA filings: List of proprietary products identified which are to be developed post patent expiry - Is filing 10 ANDAs with US FDA by June 2008
Combination of organic and inorganic growth
ACTIVE PHARMACEUTICAL INGREDIENT Second largest producers of Ciprofloxacin and Ranitidine in IndiaProvides contract manufacturing services to world’s leading generic pharmaceutical companies
Key Focus Area: CVS, Ant diabetic, CNS, Pain management& Gastro Intestinal
Expanding production in CNS, CVS, anti-diabetic and pain management therapeutic segments
Capacity expansion already underway to meet domestic demand
Revenues (Rs millions)
Revenues (Rs millions)
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Business SegmentsRESEARCH AND DEVELOPMENT
State of the art R&D laboratory at Goa (approved by DSIR) and New Delhi for innovation in the area of new molecule and formulation development and drug delivery
New research laboratory set up at Kurkumbh to provide chemical synthesis and development services
The company is also working towards developing API's which are likely to go off patent in the next few years as their market size is estimated at USD 20 billion
Joint product development pacts in place with reputed international and local institutions for biopharmaceuticals
GENERIC DRUG DEVELOPMENT PIPELINE
Filing 10 ANDA’s with USFDA by June 2008, having aggregate market size of 17 billion in US, into CVS, CNS, Pain management & Gastro Intestinal Segments
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Manufacturing CapabilitiesFORMULATION
Marksans state of the art manufacturing facilities in Goa are of international standards adhering to stringent quality norms and are USFDA compliant. Its world class manufacturing capabilities cater to APIs as well as formulations.
Adhering to USFDA guidelines with approvals from UK MHRA, Australian TGA and Brazilian ANVISA health authorities
One of the biggest manufacturing facility for soft gelatin capsules and tablets in Asia (Capacity of 2.50 billion tablets/line/annum for tablets, 4.8 billion capsules / line / annum) respectively
ACTIVE PHARMACEUTICAL INGREDIENT Marksans has two large multi-product API manufacturing facilities located at Kurkumbh, Maharashtra which are re-benchmarked to CGMP standards
USFDA approval expected in next 9-12 months
MPL has increased the annual capacity of its flagship product Ciprofloxacin from 600 MT to 1000 MT and for Ranitidine from 360 MT to 600 MT
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Recent AcquisitionsHALE GROUP - UK
The Company has entered into a share purchase agreement with UK's Hale Group to acquire its entire share capital, along with its subsidiary company Bell Sons & Co (“Bell”)
Bell is a well-established manufacturer of a broad range of OTC pharmaceuticals having full approval of the UK MHRA and currently holds 38 product licenses. Licensed products contribute over 45% of Bell’s total turnover
The company clocked a turnover of £ 8.03 million and £ 8.94 million respectively for FY’05 and FY’06 (year ending December). The EBITDA margins for the said period stand at 12% and 14% respectively
Rationale: Bell is an established player with strong goodwill
Access to the regulated UK & Europe market
Synergies and cost saving in manufacturing and R&D
NOVA PHARMACEUTICALS - AUSTRALIA MPL acquires Nova Pharmaceuticals (NP), a company that specializes in R&D and marketing of generics
NP has a basket 14 products, with additional 25 products filed for TGA approvals
NP has presence in the top pharmacies and major chain stores for the supply of generics and OTC
Rationale: Gain foothold in a key pharmaceutical market
New product introduction and cost saving by shifting production to India
STRATEGY
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Inn
ov
ati
on
& V
alu
e C
ha
in T
rav
ers
al
Enterprise Maturation
Current State
Niche Player
Geographic expansion – Semi and Regulated Markets
Product expansion – NCEs, biologics, controlled /high potency substances
Therapeutic area expansion – critical care, respiratory,CNS, anti-infectives, immunology, life style, neutraceuticals
Future State
Integrated Player
Ve
rtic
al
Inte
gra
tio
n
Business expansion – CRAMS
Product Innovation – reformulation,Controlled release
Global strategy – global alliances, innovator partnershipscollaborative R&D, licensing deals, M&A
Multi-product, multi-specialty, multi-geography, fully integrated enterprise
VisionStrategy aimed at differentiation, high margin niche areas, life cycle extension and product innovation
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Europe, US & Emerging Markets Become preferred manufacturing partner for large MNC pharma companies Establish a strong presence in the US generic pharmaceutical market through acquisition of a
target company to exploit MPL’s low cost API, drug formulation and R&D capabilities Focus on building IP assets specially in Niche dosage forms Out-License IP to drive growth / scalability Build and launch portfolios of generic products in niche segments, technology driven
products. In parallel, seek out newer markets with potential Build significant OTC presence in regulated markets Integrating & leveraging acquired company strengths to fuel internal growth
India Become a top 10 fully integrated pharmaceutical company with a diverse portfolio of ethical,
branded, generic and OTC products Continue building presence in speciality markets such as oncology and CNS Continue evolution as an innovative developer of patented, NDDS, and in-licensed products
(RISUG, GCSF, EGF) and post-patent products
Geographical Strategic Goals
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Rapid filing of ANDAs / MAs, DMFs/COSs into US, Europe & Emerging Markets
Expand CRAMS services in the Regulated Markets
Acquisitions of growing, profitable pharmaceutical companies and/or products.
Commercialize strong pipeline of over 10 new API products
Leverage economies of scale and integrating API and formulation manufacturing
Pursue additional product in-licensing opportunities for domestic markets
Enter into out licensing arrangements with big pharma company in US, Europe to manufacture & market post patent & off patent drugs
Key Growth Drivers
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CRAMS
R&D – NCEPIPELINE
THRUST ONEXPORTS
DOMESTIC FORMULATIONS
BIOPHARMACEUTICALS
Strategy
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Thrust on Exports
VISION: To become a leading player for APIs and formulations supply to global companies
COMPETITIVE EDGE: Vertical integration from R&D to API to formulations
NORTH AMERICA: Aggressive roadmap to develop sales and distribution network
Remain focused on high value of generics
Organic and inorganic buildup of portfolio
EUROPE: Tie-ups in place with top 7-8 generic formulations companies for CRAMS
Focus on selected market – UK, Germany, Central and East EU
UK Acquisition: £8-10m sales with strong product pipeline and brand equity
AUSTRALIA: Acquired a marketing company with basket of 14 products, with additional 25 products filed for TGA approvals
EMERGING MARKETS: Expanding to countries and across products
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Domestic Formulations
CURRENT STATUS AND STRATEGY
Mark Remedies caters to the GI disorders and Respiratory infections segment. This is a mass segment category with promises of large volumes
Enhance presence in Oncology and creating a base in lifestyle therapeutic segments
Focus on Biotechnology drugs, antineoplastics and immunomodulators
In-licensing to be one of the major growth drivers
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Biopharmaceuticals
CURRENT STATUS
Number of in-licensing / joint R&D agreements in place with international agencies and local research institutes for product development and / or marketing
Some of the products approved / under development
Interferon Alpha 2b: world market ~ USD 1 billion
Granulocyte Colony Stimulating Factor (GCSF): World market ~ USD 2 billion
Epidermal Growth Factor (EGF) - NDDS
Interlucin 2
STRATEGY
Aggressively scouting for more in licensing opportunities with the innovator companies
Increase the marketing infrastructure on PAN India basis to market the products
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Research & Development
~ 45 products already developed. > 40 products under development
Building IP assets and registering them internationally
Focus on end to end solutions, to develop core API’s for ANDA products in-house.
Concentrating on development of Niche Liquid gel products
Leveraging expiry of patents: developing products for growth areas such as cardiovascular and anti diabetics
Tie ups in place with big MNC & Generic companies for first to launch status on many products following patent expiration
Joint product development pacts in place with reputed international and local institutions for biopharmaceuticals
MPL is already working on two NCEs in collaboration with Original patent holders, along with Indian Council of Medical Research, Govt. of India
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CRAMS
CURRENT STATUS
The Company has alliances with the top 7-8 MNC generic companies for contract manufacturing of ~ 30 generic products for the European markets
Licensing agreements in place with numerous companies for development and supply of products for 7-10 years
STRATEGY
The company plans to enhance its product portfolio with the addition of 12-13 products p.a.
Offering CRAMS services for existing and emerging markets is envisaged as one of the major driver and revenue earner for the company
FINANCIAL HIGHLIGHTS
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Financial Highlights
Particulars FY2005 FY2006 FY2007 9M FY2008
USD Millions (Audited) (Audited) (Audited) (Unaudited)
Total Income 62.78 76.49 63.39 42.01
Total Expenditure 51.78 63.82 56.21 34.28
EBITDA 11.00 12.66 7.18 7.73
Depreciation 1.76 2.04 1.85 1.60
Interest 2.94 2.68 2.91 2.55
PBT 6.29 7.95 2.42 3.58
Tax 1.13 2.15 0.67 0.35
PAT 5.17 5.79 1.75 3.24
Ratios
EBITDA Margins (%) 17.5% 16.6% 11.3% 18.4%
PAT Margin (%) 8.2% 7.6% 2.8% 7.7%
PROFIT AND LOSS
USDINR 39.5
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Financial Highlights
USD Millions FY2005 FY2006 FY2007
Shareholders' Funds 25.82 30.38 32.15
Secured Loans 21.01 20.51 25.57
Unsecured Loans 1.01 56.46 55.19
Total Debt 22.28 76.96 80.76
Total Liabilities 48.10 107.34 112.66
Net Block 25.82 31.65 35.19
Investments 0.00 0.00 0.00
Inventories 12.41 20.00 31.14
Sundry Debtors 14.43 12.91 13.42
Cash and Bank Balance 2.53 50.13 40.00
Loans and Advances 3.29 3.29 5.06
Total Current Assets 32.41 86.08 90.13
Current Liabilities 9.11 8.35 11.14
Provisions 0.51 1.27 0.25
Misc. Expenses 0.51 0.51 0.51
Net Deferred Tax -1.01 -1.52 -2.28
Total Assets 48.10 107.34 112.66
BALANCE SHEET
USDINR 39.5
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Background for FY2007 ResultsKEY REASONS
Stiff competition in APIs namely Ciprofloxacin and Ranitidine due to dumping from China
Price erosion ~ 35%
Reduced production in these APIs resulted in decrease in sales
STRATEGY ADOPTED
COS approval obtained for Ciprofloxacin, expected for Ranitidine & Metformin shortly to enable exports to Europe with 50% more margin
More high value products like Losartan, Metformin, Naproxen, etc with COS Filings
US FDA approval expected for all these products
Focus on high growth life style segment formulations mainly in domestic market, which are exhibiting strong growth rates
Integrating API operations with formulations
OUTCOME
Extremely bullish trend in domestic life style segment
Rise in prices of Ciprofloxacin, Ranitidine in China
MPL’s CRAMS business in Europe is growing
20 ANDA filings expected by Dec 08 and 30 by Dec 09, resulting in Business from USA in excess of US$ 100 million in FY 2011-12
Exclusive Out licensing arrangements with leading generic companies to give a boost to its Exports
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Shareholders fund USD 32.15 million
No. of issued Shares 35.94 million
Listed at BSE and NSE
Market Price Rs. 257 as on 8 February 2008
Market Capitalisation Rs. 9.24 million (US$ 234 million)
52 weeks high / Low High High: Rs 351.6 Low: Rs 44.2
Share Holding Pattern
(31 December 2007)
Category Holding
Promoters 47.41%
Banks/FIs/MFs 1.46%
Corporate Bodies 27.61%
Public 23.52%
Total 100.00%
Equity Capital Structure
USDINR 39.5
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Investment Highlights Fully integrated company with strong presence across entire value chain from
APIs to formulations to biopharmaceuticals and across key therapy areas and both the evolving and developed markets
Strong R&D focus strategically positions MPL in the new patent regime
Aggressive foray into new geographies and regulated markets through acquisitions (UK and Australia) to expand global footprint
Focus on high-growth therapeutic segments such as lifestyle, anti-diabetic, cardiovascular to advantage from strong demand from US and EU markets
Thrust on Biotechnology: Entered the lucrative segment with 8 products in the pipeline of which 3 are already approved by Drug Controller of India
World class manufacturing facilities and strong marketing and distribution network in India
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THANK YOU
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API
Two manufacturing facilities. Strategy to focus on end-to-end
solutions and to develop APIs for ANDA products in-house.
Rapidly filing COSs/DMFs into Europe and US markets.
Exporting its products to more than 30 countries.
Provides API contract manufacturing to many of the world’s leading generic pharmaceutical companies.
Key focus areas• CVS• Anti-diabetic• CNS• Pain Management• GI
Expanding its API business by shifting from predominantly domestic market to highly regulated markets of USA and Europe.
Formulations
World class manufacturing facilities: approvals - UK MHRA, Australian TGA. US FDA approval expected shortly.
Tie-up with big MNCs globally for offering CRAMS.
Product basket covering wide therapeutic areas.
Developing post-patent products mostly supported by in house API’s for global markets.
Out-licensing tie-ups with big pharma companies for long term manufacturing and marketing.
Setting up own front ends in major global markets – US, Europe, Australia, Russia and emerging markets.
Strong marketing presence in the domestic markets - wide range of over 250 products in the domestic markets.
Speciality segment focus in domestic market.
Specialised state of the art Soft gel manufacturing plant.
Expanding registration process across geographies
R&D
• DSIR approved research labs in Goa, Pune and New Delhi.
• Key focus on:• Building IP assets and their
global registration. • End to end solutions , to
develop core API’s for ANDA products in-house.
• Development of technology driven products for the global markets (Sustained release, extended release and Soft gel delivery systems).
• Development of Niche Liquid gel products (Differentiating plank as very few key players offer the same).
• Tie ups in place with big multinationals & Generic companies for first to launch status on many products following patent expiration.
MPL is already working on two NCE’s in collaboration with Original patent holders, along with ICMR, Govt. of India.
Company’s Operations
APPENDIX
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API operations were focused on Ciprofloxacin and Ranitidine which have suffered substantial price erosion
Weaknesses
Opportunities
Threats
Attrition.
Competition
R&D speed and managing launch
Changing regulatory requirements
World class fully integrated manufacturing facilities
Strong research & regulatory capabilities Continuous identification and launch of new
markets to expand geographies Market leader position in certain key bulk drugs
with strong presence in exports Highly competent, experienced and
professional management team Strong R&D skills so as to enable in-house
product development Strong marketing platform for pan-India
presence Strong development pipeline to cater to
company’s future growth
Strengths
Regulated markets, API and formulations
CRAMS for Global markets
Lifestyle therapeutic segment in domestic market
Increasing rural penetration in domestic markets
SWOT
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Inno
vatio
n &
Val
ue C
hain
Tra
vers
al
Industry Maturation (Value Creation)1970 2005 2010
Process Engineering
Drug Intermediaries
Bulk Actives (API)
Formulations
Product PatentProcess EngineeringSynthetic ChemistryCustom SynthesisContract Research
Pharma DevelopmentContract Manufacturing
Drug Discovery R&DPreclinical Research
Clinical Research
Innovator Products (NCE, Inorganics, NDDS)
ANDAs, DMFs/COSsPost Patent Filings
Global Exports (Regulated Markets)Regulatory Approvals / services(US FDA, UK MHRA, EDQM, TGA, ANVISA)Strategic Alliances & PartnershipsIn-house R&D (Goa, Pune, IITD)First-to-file (Para IV)Global AcquisitionsIn-/Out-Licensing deals
Marksans Footprint
BUSINESS SEGMENT - Capabilities across the value chain
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Global Foray: Key features:
Main markets: US, Europe, United Kingdom, Australia, and other emerging markets. Plans in place to tap huge Russian and CIS markets. Initiated dossier filling in these countries
Collaborations: MPL’s products are available through collaborations with big MNC companies
Quality Manufacturing: Its robust product basket and quality control measures as well as manufacturing accreditations such as UK MHRA and Australian TGA approved facilities enable MPL to establish its presence in the global markets
ANDA filings: List of proprietary products identified which are to be developed post patent expiry - It is filing 10 ANDAs with US FDA by June 2008
Sales Front ends: Rapidly built up a generic sales front end in the USA with investments in sales distribution.
Acquisitions & approvals: The Company intends to grow inorganically in the global markets: Already acquired an Australian company - Nova Pharmaceuticals. MPL plans to grow
inorganically in the US and Europe markets as well Already received approval for 5 products in Australia
With a strong focus on the US markets, the company has entered into an agreement with Pharmgen LLC, US for the development and filing of 11 ANDA's. The product list is a mix of off-patent and post patent protected molecules with cumulative annual sales of about USD
17 billion in the US
BUSINESS SEGMENT - Global Formulations
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Coverage and Divisions
Significant presence in major therapeutic areas in domestic market
Wide range of over 250 products in the domestic markets (80 feature in the ORG list)
These products are marketed through 5 distinct divisions as enumerate below:
Marketing Capabilities:
Pan India Field force of ~ 450 MRs
Carved a distinctive image for its products with innovative and aggressive marketing strategies
Sr. No Speciality Market Size (Rs millions)
Expected Market Growth %
Revenues FY 2007
(Rs Crore)
1 Cerebella: CNS (Neuro-Psychiatry) 19,340 12 110
2 Criticare: Oncology + Critical care 9,000 14 130
3 Mark Remedies: Gastro, Respiratory and Gynaecology
81,230 12 150
4 & 5 Zenmark and Marksans: GP & Institutions
124,430 11 400
Others 290
Total Market 230,400 12 1080
BUSINESS SEGMENT - Domestic Formulations
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Second largest producers of Ciprofloxacin and Ranitidine in India (Both COSs filed). Together the Ciprofloxacin Hydrochloride and Ranitidine Hydrochloride rank amongst the top 20 highest selling drugs in the world. COS already received for Ciprofloxacin
Provides API contract manufacturing services to world’s leading generic pharma companies
Key Focus Area: CVS, Ant diabetic, CNS, Pain management& Gastro Intestinal
The company is addressing antibiotic and antiulcerant therapeutic segments and in the process in expanding production into CNS, CVS, anti-diabetic and pain management therapeutic segments which are growing radically. These segments are estimated to be worth approximately US $ 20 billion over the next five years
In the domestic markets MPL has embarked on ambitious expansion projects to scale up its existing capacity, to enter new therapeutic segments covering high growth lifestyle-related diseases
MPL has reputed clientele and has been supplying and exporting its products regularly to big pharma companies & to various countries like Japan, Latin America, Bangladesh, Spain, Egypt, Jordan, Iran, Mexico, Germany and Africa
BUSINESS SEGMENT - API
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Expanding its API business by shifting from predominantly domestic market to the highly regulated markets of US and Europe
New API’s to be developed based on key products for formulation development with focus on Post patented Products
Develop several API’s to provide cost and time advantage to complement MPL’s US and Europe generic filings
Continue to be the preferred third party API supplier to the generic industry
Rapidly file COSs/DMFs into Europe and US markets (5 DMFs and 5 COSs in 2008-09)
New Product introductions: Commenced commercial supply of new products during the year Several validation pivotal batches have been sent to global generic players for their dossier
filings
BUSINESS SEGMENT - API Strategy
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Board of Directors
MD & CEO
Head HRCFOR&D/RAAPIFormulations
Domestic
Global
Manufacturing
Manufacturing
Sales
Formulation
API
RA
Purchases
Distribution
CS and Legal
Accounting, taxation
and IT
MANAGEMENT - Organization Chart
40
Mr. Mark Saldanha – Managing Director & CEO
V Nagraj – Wholetime Director
Dr. Kim Tan – Director, nominee of Springhill Bio-Venture Fund
Mr. Ajay Mittal – Director, nominee of UTI Venture Fund
Mr. Mahesh Parekh - Independent Director
Mr. Kumar Nair - Independent Director
MANAGEMENT - Board of Directors
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Mark Saldanha Managing Director & CEO
Mr. Mark Saldanha, was associated with Glenmark Pharmaceuticals Ltd. as a whole time director and was instrumental in the growth of the company in mid and late nineties, before promoting this venture. He is well versed in the overall management of the company and has vast experience in managing the marketing, production and finance function of the company
The Promoter is currently engaged in the Pharmaceutical business only
The Company was set up by Mr. Mark Saldanha, a first generation entrepreneur and is rapidly expanding its business operations
MANAGEMENT - Promoter
42
Name Designation Profile
V. Nagaraj Director - Sales & Marketing
He has done Graduation in Science and PGDMM. He has around 25 years of experience in Sales & Marketing. He is responsible for entire sales & marketing of Domestic Market
Jitendra M Sharma
Chief Financial Officer
He is a qualified chartered accountant and cost accountant and is having 13 years of experience in resources mobilization, developing systems, MIS and taxation
R.K. Jhingan Sr. Vice President -Business Development
He is a bachelor of pharmacy. He has vast experience of over 20 years in pharmaceutical industry. He looks after molecules and co-development and entering into research alliances
Bela Bhandari Chief Marketing Officer
She is a PGDBM, B. Pharma and has a good exposure in Export marketing. She is involved in the international marketing
Dr. P. B. Deshpande
Director – API He has done Doctorate in Organic Chemistry. He has around 24 years of experience in R&D, Product Development & Plant Operations. He is responsible for Strategic Business Development of APIs & overall in-charge of API operations at Kurkumbh Plant
Dr. Balwant S. Desai
Director – Quality and Regulatory Affairs
He has done Doctorate in Analytical Chemistry. He has around 20 years of experience in Quality Control/Assurance/Regulatory Affairs. He is responsible all Q.A./Q.C./R.A. activities
Mr. A. V. S. Ravishankar
General Manager - Operations
He is a master of pharmacy. He has handful in experience and plant operations. He is responsible for the entire plant at Verna, Goa
Mr. Rajan Sawant Head – Human Resources
He has Master's Degree in labour Study from M. I. L. S. Mumbai. He has also done B. G. L. & D. M. M. He has excellent track record of 15 years in H. R. He is heading entire gamut of HR initiatives for the organization
MANAGEMENT - Key Management Personnel
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Introduction Division dedicated to neurosciences for
treatment of psychiatry and neurological disorders
This market is poised for rapid growth due to lifestyle changes and growing awareness
Vision To achieve a growth of 100% in the
turnover by 2010 Be amongst the top 5 players over a period
of five years
Segment addressed Antipsychotic Antidepressant Antiepileptic Anxiolytic Memory Enhancer Stroke
New Launches
Indication Market Size
Rs mio
Risperidone Atypical Antipsychotic
900
Piracetam Memory enhancers 1200
Lorazepam Ataractic / anxiolytic 2200
Citicoline Cerebral strokes 1200
Methyl Prednisolone
Stroke/ spinal cord injury
450
Lamotrigine Epilepsy 2400
IVIG Immune dysfunction (GBS)
1500
PRODUCT RANGE - Cerebella: CNS (Neuro - Psychiatry)
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Introduction Globally Oncology is the fastest growing therapeutic segment MPL is carving out a niche position in Oncology through its Criticare division Criticare division focuses on Cardio care and Life saving higher end antibiotics In - licensing is expected to be the key growth driver for this division
Vision Marksans to have the first mover advantage of introducing First time niche molecules like
EGF,IL2, Oncophage, INF-Gel,EPO and Cancer Vaccine under this division. In-licensing products like Enoxaparin are to be the key growth drivers for cardio care
Biotechnology drugs, antineoplastics and immunomodulators to be the front runners To launch one to two in-licensed biotech products every year in the domestic market through
its Criticare division To capture 4% of Indian Oncology market by 2010 & 6% of domestic Critical care market by
2010
New Launches Indication Market Size (Rs mio)
Voriconazole Systemic Aspergillosis and Candidiasis. 700
Capecitabine Metastatic CRC and Breast Cancer 2,000
Gefatinib NSCLC as Fourth Line treatment 1,000
PRODUCT RANGE - Criticare: Oncology + Critical care
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IntroductionA multi- specialty division dedicated to GI disorders and Respiratory infections
~ 40% of domestic pharma market of Rs 28,000 crore is attributed to these two disorders
MPL markets Prescription/Ethical products focused on women's health, geriatric disorders, internal medicine, nutritional support and lifestyle disorder associated with gastro-intestinal, cardiology and diabetology under this division
VisionTo reach a turn over of INR 37 crores and emerge as a strong player in the segment
Segment AddressedGastro, Respiratory, Antibiotics, Gynaecology + Others
New Launches Indication Market Size
Rs mio
Salmon Calcitonin Osteoporosis 1200
Adefovir Depivoxil Hepatitis B 1000
Ursodeoxycholic Acid
Cholestatic Liver Disease
2200
Terlipressin Variceal Bleeding 240
Lactitol Monohydrate
Constipation, Hepatic Encephalopathy
2000
Pantoprazole + Sodium Bicorbonate
GERD, Ulcers 3000
Drotavarine Antispasmodic 2200
Codans Antitussive 4600
Rabemark (Rabeprazole)
Anti Ulcerant 3000
PRODUCT RANGE - Mark Remedies
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These divisions are focused on branded generic products and OTC and have 150 products covering almost the entire Pharmaceutical segment
They mainly cater through tender business to private hospitals, government hospitals, public sector undertakings, AFMSD, Indian Railways, Port Trust, etc
The current product range contains wide spectrum of products to capture maximum business in Institutional sector
The current business is around Rs. 40 Crore
The basket includes orals, parentrals and topicals
Health insurance is gaining wide acceptance and will further give an impetus to Institutional business
PRODUCT RANGE - Zenmark and Marksans: GP & Institutions
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Product Licensor / Joint R&D Indication Remarks
Interferon Alfa 2b Center of Genetic Engineering & Biotechnology, Cuba
Viral hepatitis infections & hematological cancers
Approved and registered for import and marketing, world market size: $1.0 billion (USD)
Granulocyte Colony Stimulating Factor (GCSF)
Beijing Four Rings, China Protein stimulator of bone marrow cells
Phase III trials completed, DCI approval received, world market size: $2.0 billion (USD)
Erythropoietin Beijing Four Rings, China Treatment of anemia in HIV and cancer patients
Product registration underway, world market size: $2.0 billion (USD)
Interlukin 2 Laboratorio Pablo Cassara, Argentina Melanoma and renal cell carcinoma
Phase III trials completed, product in registration with DCI
Recombinant epidermal growth factor cream (EGF)
Center of Genetic Engineering & Biotechnology, Cuba
Patients undergoing superficial and deep radiotherapy
Drug Control of India approval received, Product launch in Q1 of current fiscal year
Citicoline Laboratorios Gramon, Argentina Cardiovascular disorder Dossier awaited from the manufacturer, Phase III trials
Biopharmaceutical Pipeline
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ACQUISITION - Hale Group: Overview Marksans Pharma has entered into a share purchase agreement with UK's Hale Group to
acquire its entire share capital, along with its subsidiary company Bell Sons & Co (“Bell”). Marksans is acquiring Hale through its 100% subsidiary Marksans Pharma UK. The company is equally owned via the holding company by Philip Hale and Linda Shepherd
Bell is a well-established manufacturer of a broad range of OTC pharmaceuticals having full approval approval of the UK MHRA and currently holds 38 product licences. Licensed products contribute over 45% of Bell’s total turnover
Bell manufactures licensed products both as own branded products and, for certain customers, in own label form together with a range of unlicensed products. Customers include retailers, pharmacies, chemist wholesalers and cash and carry outlets
The company employs 106 people at its freehold licensed manufacturing site in Southport, Merseyside and has further 12 employees providing sales administration, buying and technical support
The company had clocked a turnover of £ 8.03 million and £ 8.94 million respectively for FY’05 and FY’06 (year ending December). The EBITDA margins for the said period stand at 12% and 14% respectively
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Product Basket:
Cough and cold remedies
Galenicals
Vitamins
Palliative and healthcare items
Oils
Antiseptics and disinfectants
The Company currently holds 38 product licences registered with MHRA. Licensed products contribute over 45% of the Company’s turnover
Under the OTC pharmaceuticals, the Company supplies its “own label” pharma products to all of the UK’s leading supermarket chains. The own label market now accounts for more than 45% of the Company’s total turnover
Product Group
9%
15%
2% 2% 6%
45%
5%
12%
4%
Antiseptics Bought-ins LiquidsOral Liquids Oils OintmentsPowders Sachets Misc
ACQUISITION - Hale Group: Products
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The company is a preferred supplier to more than 300 customer all over the country, including the leading retail sector brands and major chemist wholesalers
UK markets represents 80% of the customer base and two third of total sales. The company’s largest customer accounts for 6% of total sales only. Thus the business is not customer centric
The Company has been in the export markets for more than 80 years now. Its products are well recognised and respected in the overseas markets
The company products are sold in more than 40 countries. Key markets are West Africa and Middle East
Turnover by Sector
46%
33%
21%
Retailer Wholesaler Export
ACQUISITION - Hale Group: Markets
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P&L SummaryPounds in million
The company has shown steady and sustained growth over the past 5 years, with turnover increasing by over 40% from £ 6.3 million in 2001 to £ 8.9 million in 2006. Based on the current performance growth is currently running at 5% per annum
The slight decline in gross margin and profitability in 2005 reflects the impact of the new manufacturing plant installed in that year leading to an increase in salary and depreciation costs. The gross margin going forward is likely to improve as the fixed elements of salary and depreciation would form a smaller percentage of cost of sales as turnover increases
Particulars FY2002 FY2003 FY2004 FY2005 FY2006 FY2007E
Turnover 6.76 7.28 8.01 8.03 8.94 9.33
Gross Profit 1.67 1.90 2.12 1.59 2.00 2.13
EBITDA 0.99 1.20 1.39 0.96 1.24 1.29
Gross Profit Margin 25% 26% 27% 20% 22% 23%
EBITDA Margin 15% 16% 17% 12% 14% 14%
ACQUISITION - Hale Group: Financial Summary
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ACQUISITION - Hale Group: Financial Summary
Particulars FY2002 FY2003 FY2004 FY2005 FY2006
AssetsFixed Assets 2.54 2.47 3.27 3.07 2.80Current Assets 2.26 2.87 2.85 3.32 4.27Total 4.79 5.34 6.11 6.40 7.06
LiabilitiesShare Capital 0.01 0.01 0.01 0.01 0.01Revaluation Reserve 0.40 0.39 0.39 0.39 0.38Profit and Loss Account 2.94 3.47 4.12 4.37 4.76Current Liabilities 1.45 1.47 1.60 1.63 1.92Total 4.79 5.34 6.11 6.40 7.06
Balance Sheet SummaryPounds in million