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CURRICULUM VITAE

MARIANNE ELIZABETH BRONNER Albert Billings Ruddock Professor mbronner@caltech.edu Division of Biology and Biological Engineering TEL: 626 395-3355 California Institute of Technology Pasadena, CA 91125

EDUCATION

1975 - 1979 Johns Hopkins University, Jenkins Department of Biophysics Ph.D. in Biophysics 1971 - 1975 Brown University, Providence, RI Sc. B. in Biophysics with Honors

PROFESSIONAL EXPERIENCE

2000 – present Albert Billings Ruddock Chair of Biology, Caltech 1996 – present Professor of Biology, Caltech 2010 Visiting Professor, College de France 2008 - present Visiting and Honorary Professor, University College London 2001 -- 2003 Caltech, Chair of the Faculty

1985 - 1996 Professor (1990-96), Associate Professor (1987-90), Assistant Professor (1985-87), Developmental and Cell Biology, Physiology and Biophysics (1980-18985), U.C. Irvine 1990 - 1996 Associate Director, Developmental Biology Center, U. C. Irvine 1979 - l980 HHMI Research Associate, Johns Hopkins University

HONORS AND AWARDS

National Academy of Sciences, Elected 2015 NIDCR, Board of Scientific Counselors, 2015 - Conklin Award, Society for Dev. Biol. Women in Cell Biology Senior Award, 2012 President, International Society for Differentiation (Nov. 2012-14) Secretary, International Society for Developmental Biology (2010-2013) Board of Directors, Gordon Research Conferences (2006-2012; Chair, 2011) Conference Evaluation Committee, Gordon Research Conferences (2013-2017) President, Society for Developmental Biology (2009); Board of Directors (2005-10) Fellow, American Academy of Arts and Science (2009) Keck Foundation Young Scholar’s Scientific Advisory Committee (2009-2012) National Institute of Dental and Craniofacial Research Council (2006-2010) Viktor Hamburger Lecturer, Washington University, 2005 BUSAC Award for Excellence in Teaching, 2005, & 2001

Harvey Lecturer, Rockefeller Univ., 2004 Scientific Advisory Board, March of Dimes (2004-2009) Javits Award, NINDS (2002-2009) Chair of the Faculty, Caltech (2001-2003) Chair, Keystone Meeting on Neural Crest and Spinal Cord (2002) Chair, Developmental Biology GRC (2001), Neural Development GRC (1994) Scientific Advisory Board--Muscular Dystrophy Association (1993 - 1999)

Scientific Advisory Board--Searle Foundation (1995-1999) Forbes Lecturer, Marine Biological Laboratory (1999) Embryology Course Co-Director, Marine Biological Laboratory (1997-2001) ASCIT Award for Excellence in Teaching (1997-98) Distinguished Research Award. U.C Irvine (1994)

American Society for Cell Biology, Council (1994-7), Publications (1992-97) Alfred P. Sloan Foundation Research Fellow (1986 - 1990)

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EDITORIAL BOARD SERVICE

Developmental Biology, Editor-in-Chief, 2014- present; Associate Editor, 1995-2013 eLife, Reviewing Editor, 2013-present Journal of Cell Biology, Monitoring Editor, 1994 – present Molecular Biology of the Cell, Monitoring Editor, 2004-present Development, Editorial Advisory Board, January 1989 - present Cell Communication and Adhesion, Editorial Board, 2001- Molecular and Cellular Neuroscience, Editorial Board,1994 – Mechanisms of Development, Editorial Board, October 1995 - Journal of Neurobiology, Editorial Board, January 1996 – 2006 Journal of Neuroscience, Reviewing Editor, January 1996 – August 2000 Neuron, Editorial Advisory Board, January 1993 - 1998 Journal of Neurocytology, Editorial Board, 1992 - 1998 Seminars in Neuroscience, Editorial Advisory Board, 1990 - 1998 Perspectives in Developmental Neurobiology, Editorial Advisory Board, 1991 - 1994 Journal of Experimental Zoology, Associate Editor, January l988 - 1992 Journal of Anatomy and Embryology, Editorial Board, January 1990 - January 1992 Seminars in Developmental Biology, Guest Editor, 1989-1990 CRC Year Book of Developmental Biology, Advisory Board, 1988 - 1990

RESEARCH INTERESTS Gene Regulatory Network Underlying Neural Crest Development– We study the signaling and

transcriptional interactions that lead to neural crest formation both at the tissue and the molecular level. We are applying gain- and loss-of-function approaches coupled with regulatory analysis and bioinformatics at a systems level to interrogate the molecular interactions that comprise a neural crest gene regulatory network.

Early Patterning of the Placodes - Identification and functional characterization of molecules

involved in formation and specification of the ectodermal placodes, with emphasis on induction, lineage decisions and morphogenesis.

Evolution of the Neural Crest and Placodes: The neural crest and ectodermal placodes are

uniquely vertebrate inventions. We are cloning orthologues of neural crest and placode “marker genes” from a basal vertebrate (lamprey) and non-vertebrate chordate (amphioxus) as well as isolating regulatory regions for these markers. We examine relationships in their regulatory machinery by comparative analysis of their enhancers and by performing cross-species promoter expression.

Neural Crest Cell Migration - A variety of cell labeling techniques, including DiI-labeling and

microsurgical grafts, are used to follow the pathways of neural crest migration in the vagal, trunk and hindbrain in a number of vertebrate species. We have examined the role of cell-cell and cell-substrate of both an attractive and inhibitory nature in neural crest migration.

RESEARCH SUPPORT

NIH P01 HD037105 (Davidson, PI, Bronner-Fraser, Project PI) 3/1/9-5/1/19 From egg to embryo: Gene Regulatory Circuitry in Development

Examine the effects of loss-of-function of known neural plate border and neural crest specifiers as well as newly identified transcription factors; Isolate regulatory regions of neural crest specifier and downstream targets; Establish direct relationships within the network by identification of transcription factor binding sites within regulatory regions.

NIH R01 DE16459 (Bronner-Fraser, PI) 7/1/04-6/30/15

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Ectodermal Placode Development into Sensory Structures Further characterize the cellular and molecular events underlying placode development, focusing on the olfactory placode domain, and how these cells obtain their prospective fates rather than becoming neural crest.

NIH R01 DC011577 (Bronner, P.I; Streit, co-PI) 2/12/12 – 2/11/17 Gene regulatory network controlling commitment to ear identity. Examines t gene regulatory network responsible for vertebrate ear development as a blueprint for ear formation and identification of new candidate genes involved therein.

NIH R01NS086907 (Bronner, P.I.) 02/15/2014 – 01/31/2019 Regulatory Changes Mediating Emergence of Novel Neural Crest Traits Examines gene regulatory changes that enabled emergence of new cell types during neural crest.

NIH R01DE024157 (Bronner, P.I.) 06/01/2014 - 05/31/2019 Gene Regulatory Network Controlling Cranial versus Trunk Neural Crest Program Examines axial level specific differences in the transcriptomes of cranial and trunk migrating neural crest cells and determines functional differences that may lead to formation of distinct derivatives.

PUBLICATIONS 1. Bronner, M.E. and Pysh, E. S. (1976). Additivity of the effects of salt and ethylene glycol on DNA

circular dichroism. Biopolymer 15, 589. 2. Bronner, M. E. and Cohen, A. M. (1979). Migratory patterns of cloned neural crest melanocytes

injected into host chicken embryos. Proc. Natl. Acad. Sci. USA 76, 1843. 3. Bronner-Fraser, M. E. and Cohen, A. M. (1980). Analysis of the neural crest ventral pathway

using injected tracer cells. Devl. Biol. 77, 130-141. 4. Bronner-Fraser, M. E. Sieber-Blum, M., and Cohen, A. M. (1980). Clonal analysis of the avian

neural crest: Migration and maturation of mixed neural crest clones injected into host chicken embryos. J. Comp. Neurol. 193, 423-434.

5. Bronner-Fraser, M. E. and Cohen, A. M. (1980). "The Neural Crest: What Can It Tell Us About

Cell Migration and Determination?" In: Current Topics, in Develop. Biol. 15. Academic Press, New York. pp. 1-25.

6. Bronner-Fraser, M. E. (1982). Distribution of latex beads and retinal pigment epithelial cells

along the ventral neural crest pathway. Devl. Biol. 91, 50-63. 7. Bronner-Fraser (l982) Analysis of Neural Crest Migration and Differentiation Using a

Microinjection Technique". International Journal of Neurology 16: 73-94. 8. Bronner-Fraser, M. E. (1984). Latex beads as probes of a neural crest pathway: the effects of

laminin, collagen, and surface charge on bead distribution. J. Cell Biol. 98, 1947-1960. 9. Coulombe, J. N. and Bronner-Fraser, M. E. (1984). Translocation of latex beads after laser

ablation of the avian neural crest. Devl. Biol. 106, 121-134. 10. Bronner-Fraser, M. (1984). "Transplantation by Microinjection: Heterospecific Analysis of Avian

Neural Crest Migration and Differentiation". In: Neural Transplants (J. Sladek and D. Gash, eds). Plenum Press, Inc., New York. pp. 13-42.

11. Bronner-Fraser, M. (1984). "Latex Beads with Defined Surface Coasts as Probes of Neural

Crest Migratory Pathways". In: Role of Extracellular Matrix in Development. 42nd Annual

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Symposium of the Society for Developmental Biology (Robert Trelstad, ed). Alan Liss, New York. pp. 399-432

12. Bronner-Fraser, M. E. (1985). Effects of different fragments of the fibronectin molecule on latex

bead translocation along neural crest migratory pathways. Devl. Biol. 108, 131-145. 13. Bronner-Fraser, M. E. (1985). Alterations in neural crest migration by an antibody that affects

cell adhesion. J. Cell Biol. 101, 610-617. 14. Howard, M. and Bronner-Fraser, M. (1985). The influence of neural tube derived factors on

differentiation of neural crest cells in vitro. Histochemical study on the appearance of adrenergic cells. J. Neurosci. 5, 3302-3309.

15. Bronner-Fraser, M. (1986). Analysis of the early stages of trunk neural crest migration in avian

embryos using the monoclonal antibody HNK-1. Devl. Biol. 115, 44-55. 16. Krotoski, D., Domingo, C. and Bronner-Fraser, M. (1986). Distribution of a putative cell surface

receptor for fibronectin and laminin in the avian embryo. J. Cell Biol. 103: 1061-1072. 17. Howard, M. and Bronner-Fraser, M. (1986). Neural tube derived factors influence the

differentiation of neural crest cell in vitro: Effects on activity of neurotransmitter biosynthetic enzymes. Devl. Biol. 117: 45-54.

18. Guillory, G. and Bronner-Fraser, M. (1986). An in vitro assay for neural crest cell migration

through the somites. J. Embryol. Exp. Morph. 98: 85-97. 19. Bronner-Fraser, M. (1986). An antibody to a receptor for fibronectin and laminin perturbs cranial

neural crest development. Devl. Biol. 117: 528-536. 20. Coulombe, J. N. and Bronner-Fraser, M. (1986). Cholinergic neurons acquire adrenergic

transmitters when transplanted into an embryo. Nature 324: 569-572. 21. Krotoski, D. and Bronner-Fraser, M. (l986) Mapping of neural crest pathways in Xenopus laevis

in "Progress in Developmental Biology" (Ed.: H. Slavkin) Alan L. Liss, Inc., N. Y. pp. 229-233. 22. Bronner-Fraser, M. (1986). "On the Guidance of Neural Crest Migration: Latex beads as

Probes of Surface-Substratum Interactions". In: Developmental Biology: A Comprehensive Synthesis. Vol. 3.: Cell Surface in Development and Cancer (M. S. Steinberg, ed). Plenum Press, Inc., New York. pp. 301-337.

23. Bronner-Fraser, M. (l986), On the guidance of neural crest migration: Latex beads as probes of

surface-substratum interactions. American Zoologist 26: 555-558. 24. Thomas, L.S., Lott, I., and Bronner-Fraser, M. (l987) Effects of isotretinoin on the behavior of

neural crest cells in vitro. Devel. Biol. 123: 276-281, 25. Bronner-Fraser, M. (l987) Perturbations of cranial neural crest migration by the HNK-1 antibody.

Devl. Biol. 123: 321-331. 26. Bronner-Fraser, M. (1987) Adhesive interactions in neural crest morphogenesis. In

"Developmental and Evolutionary Aspects of the Neural Crest". John Wiley and Sons, Inc. New York pp. 11 - 37.

27. Bronner-Fraser, M. and Lallier, T., (l988) A monoclonal antibody against a laminin-heparan

sulfate proteoglycan complex perturbs cranial neural crest migration in vivo. J. Cell Biol. 106: 1321-1330.

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28. Lallier, T. and Bronner-Fraser, M. (l988) A spatial and temporal analysis of dorsal root and sympathetic ganglion formation in the avian embryo. Devl. Biol. 127, 99-112.

29. Krotoski, D., Fraser, S. and Bronner-Fraser, M. (1988). Mapping of neural crest migration in

Xenopus laevis embryos using inter- and intra-specific cell markers. Devl. Biol. 127:119-132. 30. Bronner-Fraser, M. (l988) Distribution and function of tenascin during cranial neural crest

development in the chick. J Neursci. Res. 21: 135-147. *31. Bronner-Fraser, M. and Fraser, S. (l988) Cell lineage analysis shows multipotentiality of some

avian neural crest cells. Nature 335(8): 161-164. 32. Bronner-Fraser, M. (1988) Guidance of neural crest migration during ontogeny of the peripheral

nervous system. in "Making of the Nervous System". (Ed.: C. Stern, J. Parnavelas, and R.V. Stirling), Oxford University Press, Oxford, pp. 103-137.

33. Bronner-Fraser, M. and Fraser, S.E. (l988) Application of new technologies to studies of neural

crest migration and differentiation. Am. J. of Medical Genetics. 4: 23-39. 34. Serbedzija, G., Bronner-Fraser, M. and Fraser, S.E. (1989) Vital dye analysis of the timing and

pathways of avian trunk neural crest cell migration. Development 106: 806-816. 35. Perris, R., Paulsson, M., and Bronner-Fraser, M. (1989) Molecular mechanisms of avian neural

crest cell migration on fibronectin and laminin. Devl. Biol. 136: 222-239. 36. Stern, C.D., Norris, W.E., Bronner-Fraser, M., Carlson, G.J., Faissner, A., Keynes, R.,J., and

Schachner, M. (1989) J1/tenascin-related molecules are not responsible for the segmented pattern of neural crest cells or motor axons in chick embryo. Development 107: 309-320.

37. Bronner-Fraser, M. and Fraser, S. (1989) Developmental potential of avian trunk neural crest

cells in situ. Neuron 3(6): 755-766. 38. Sechrist, J., Coulombe, J., and Bronner-Fraser, M. (1989) Combined vital dye labelling and

catecholamine histofluorescence of transplanted ciliary ganglion cells. J. of Neural Transplantation 1(3,4) 113-128.

39. Bronner-Fraser, M. (l989) Role of the extracellular environment in neural crest migration. in

"Cytoplasmic Information Systems: A Primer in Developmental Biology". Macmillan Publishing Co., New York. pp. 375-402.

40. Bronner-Fraser, M., Stern, C. and Fraser, S. (l989) Analysis of neural crest cell lineage and

migration. J. of Craniofacial Genetics and Devl. Biol. 11, 214-222. 41. Perris, R. and Bronner-Fraser, M. (1989) Recent advances in defining the role of the

extracellular matrix in neural crest development. Comments on Developmental Neurobiology. 1: 61-83

42. Leblanc, G., Epstein, M. and Bronner-Fraser, M., (1990) Differential development of cholinergic

neurons from cranial and trunk neural crest cells in vitro. Devl. Biol. 137: 318 -330. 43. Krotoski, D. and Bronner-Fraser, M. (1990) The distribution of integrin and its ligands in the

trunk of Xenopus laevis during neural crest cell migration. J. Exp. Zool. 253: 139 - 150. 44. Serbedzija, G., Fraser, S.E., and Bronner-Fraser, M. (1990) Pathways of trunk neural crest cell

migration in the mouse embryo revealed by vital dye analysis. Development 108: 605 - 612.

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45. Coulombe, J.N. and Bronner-Fraser, M., (l990) Development of cholinergic traits in the quail ciliary ganglion: expression of choline acetyltransferase-like immunoreactivity. Neuroscience 37(1): 259-270.

46. Lallier, T., Artinger, M., Matthew, W., and Bronner-Fraser, M. (1990) Distribution and

biochemical characterization of the INO antigen during chick neural crest cell migration. J. Neurosci. Res. Suppl. 13: 126-140

47. Pettway, Z., Guillory, G., and Bronner-Fraser, M. (1990) Absence of neural crest cells from the

region surrounding implanted notochords in situ. Devl. Biol. 142: 335-345. 48. Bronner-Fraser, M., (1990) Environmental influences on neural crest cell migration. Editor: Dr.

D. Stocum. Oxford University Press, New York, pp. 88-110.. 49. Bronner-Fraser, M. (1990) Experimental analyses of the migration and lineage of avian neural

crest cells. The Cleft Palate Journal 27: 110 - 120. 50. Lallier, T. and Bronner-Fraser, M., (1990) Role of the extracellular matrix in neural crest cell

migration. Seminars in Developmental Biology 1: 35 - 44. 51. Ranscht, B. and Bronner-Fraser, M. (1991) T-cadherin expression alternates with migrating

neural crest cells in the trunk of the avian embryo. Development 111: 15-22. 52. Bronner-Fraser, M. and Stern, C. (1991) Effects of mesodermal tissues on avian neural crest

cell migration. Devl. Biol. 143: 213-217. 53. Perris, R., Krotoski, D., Domingo, C., Lallier, T., Sorrell, J. M., and Bronner-Fraser, M. (l991)

Spatial and temporal changes in the distribution of proteoglycans during avian neural crest development. Development 111: 583-599.

54. Serbedzija, G., Burgan, S.E., Fraser, S. and Bronner-Fraser, M. (1991) Vital dye analysis of

sacral neural crest cell contribution to the enteric nervous system of chick and mouse embryos. Development 111: 857-866.

55. Fraser, S.E. and Bronner-Fraser, M. (1991) Migrating neural crest cells in the trunk of the avian

embryo are multipotent. Development 112: 913 - 920. 56. Stern, C.D., Artinger, K.B. and Bronner-Fraser, M. (1991) Tissue interactions affecting the

migration and differentiation of neural crest cells in the chick embryo. Development 113: 207 - 216.

57. Perris, R., Krotoski, D. and Bronner-Fraser, M. (1991) Collagens in avian neural crest cell

development: distribution in vivo and migration-promoting ability in vitro. Development 113 969-984.

58. Lallier, T. and Bronner-Fraser, M. (1991) Avian neural crest cell attachment to laminin:

involvement of divalent cation dependent and independent integrins. Development 113: 1069-1084.

59. Sechrist, J. and Bronner-Fraser, M. (1991) Birth and differentiation of reticular neurons in the

chick hindbrain: Ontogeny of the first neuronal population. Neuron 7: 947-963. 60. Bronner-Fraser, M.E. and Fraser, S.E. (1991) Cell lineage analysis of the avian neural crest.

Development Supplement 2: 17-22. 61. Artinger, K. B. and Bronner-Fraser, M.E. (1992) Partial restriction in the developmental potential

of late emigrating avian neural crest cells. Devl. Biol. 149: 149-157.

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62. Bronner-Fraser, M., Artinger, M., Muschler, J. and Horwitz, A.F., (1992) Developmentally

regulated expression of a6 integrin in avian embryos. Development 115: 197-211. 63. Bronner-Fraser, M., Wolf, J., and Murray, B.M. (1992) Effects of antibodies against N-cadherin

and N-CAM on the cranial neural crest and neural tube. Devl. Biol. 153: 291-301. 64. Akitaya, T. and Bronner-Fraser, M. (1992) Expression of cell adhesion molecules during

initiation and cessation of neural crest cell migration. Developmental Dynamics 194: 12 - 20. 65. Serbedzija, G., Bronner-Fraser, M. and Fraser, S.E. (1992) Vital dye analysis of cranial neural

crest cell migration in the mouse embryo. Development 116: 297-307. 66. Lallier, T., Leblanc, G., Artinger, K. and Bronner-Fraser, M. (1992), Cranial and trunk neural

crest cells use different mechanisms for attachment to extracellular matrices. Development 116: 531-541.

67. Lallier, T. and Bronner-Fraser, M., (1992) a1b1 integrin on neural crest cells recognizes some

laminin substrata in a Ca2+-independent manner. J. Cell Biol. 119: 1335 - 1346. 68. Artinger, K. and Bronner-Fraser, M. (1992) Notochord grafts do not suppress formation of neural

crest cells or commissural neurons. Development 116, 877-886. 69. Bronner-Fraser, M.E. (1992) "Cell lineage segregation in the vertebrate neural crest" in

Determinants of Neuronal Identity (Eds: Shankland and Macagno), Academic Press, N.Y. pp. 359-390.

70. Leblanc, G, and Bronner-Fraser, M. (1992) "Neural crest cell differentiation" in Development,

Regeneration and Plasticity of the Autonomic Nervous System. (Ed. I.A. Hendry and C.E. Hill), Harwood Academic Publishers, Reading, U.K.

71. Lallier, T. and Bronner-Fraser, M. (1993) Inhibition of neural crest cell attachment by integrin

anti-sense oligonucleotides. Science 259: 692-695. 72. Collazo, A., Bronner-Fraser, M. and Fraser, S.E. (1993) Vital dye labelling of Xenopus laevis

neural crest cells reveals multipotentiality and novel pathways of migration. Development 118, 363-376.

73. Sechrist, J. Serbedzija, G. N., Fraser, S. E., Scherson, T. and Bronner-Fraser, M. (1993)

Segmental migration of the hindbrain neural crest does not arise from segmental generation. Development 118, 691-703.

74. Scherson, T., Serbedzija, G., Fraser, S. and Bronner-Fraser, M. (1993) Regulative capacity of

the cranial neural tube to form neural crest. Development 118, 1049-1061. 75. Perris, R., Syfrig, J., Paulsson, M., and Bronner-Fraser, M. (1993) Molecular mechanisms of

neural crest cell attachment and migration on types I and IV collagens. Exp. Cell Res. 209, 103-117.

76. Perris, R., Kuo, H.J., Glanville, R., Liebold, S. and Bronner-Fraser, M., (1993) Collagen type IV

in neural crest development: distribution in situ and interaction with cells in vitro. Devl. Dynamics 198, 135-149.

77. Perris, R., Kuo, H.J., Glanville, R., and Bronner-Fraser, M. (1993) Neural crest cell interactions

with type VI collagen are mediated by the triple helical and globular domains. J. Cell Science 106, 1357-1368.

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78. Artinger, K. and Bronner-Fraser, M. (1993) Delayed formation of the floor plate after ablation of

the avian notochord. Neuron 11, 1147-1161. 79. Bronner-Fraser, M.E. (1993) "Cell interactions in neural crest cell migration" in Advances in

Developmental Biology (ed. P. Wassarman) JAI Press, Inc., Greenwich, CT., pp. 119-152. 80. Bronner-Fraser, M.E. (1993) Environmental influences on neural crest cell migration. J. of

Neurobiology 24, 223 -247. 81. Bronner-Fraser, M. (1993) Mechanisms of neural crest cell migration. Bioessays. 15, 1-10. 82. Bronner-Fraser, M. (1993) Neural Development: Crest Destiny. Current Biology 3, 201-203. 83. Selleck, M.A.J., Scherson, T.Y. and Bronner-Fraser, M. (1993) Origin of neural crest diversity.

Devl. Biol. 159, 1-11. 84. Bronner-Fraser, M. (1993) Segregation of cell lineage in the neural crest. Current Opinions in

Genetics and Development 3, 641-647. 85. Lallier, T., Perris, R., Deutzmann, R., Paulsson, M. and Bronner-Fraser, M. (1994) Neural crest

cell migration on laminin is mediated by a novel binding site for a1b1 integrin on the E8 domain. Devl. Biol. 162, 451-464.

86. Serbedzija, G.N., Bronner-Fraser, M., and Fraser, S.E. (1994) Analysis of neural crest cell

lineage in the mouse embryo. Development 120, 1709-1718. 87. Sechrist, J., Scherson, T. and Bronner-Fraser, M. (1994) Rhombomere rotation suggests

multiple mechanisms contribute to the segmental pattern of hindbrain neural crest migration. Development 120, 1777-1790.

88. Atchley, W.R., Fitch, W.M., Bronner-Fraser, M. (1994) Molecular evolution of the MyoD family of

transcription factors. Proc. Natl. Acad. Sci. USA 91, 11522-11526. 89. Bronner-Fraser, M. (1994) Neural crest cell formation and migration in the developing embryo.

FASEB J. 8, 699-706. 90. Bronner-Fraser, M. (1995) Patterning of the vertebrate neural crest. Perspectives in

Developmental Neurobiology 3, 53-62. 91. Selleck, M.A.J. and Bronner-Fraser, M. (1995) Origins of the avian neural crest: the role of

neural plate-epidermal interactions. Development 121, 526-538. 92. Birgbauer, E., Sechrist, J., Bronner-Fraser, M., and Fraser, S. (1995) Rhombomeric origin and

rostrocaudal reassortment of neural crest cells revealed by intravital microscopy Development 121, 935-945.

93. Nieto, A.M., Wilkinson, D.G., Sechrist, J. and Bronner-Fraser, M. (1995) Relationship between

spatially-restricted Krox-20 gene expression in branchial neural crest and segmentation in the chick embryo hindbrain EMBO J. 14, 1697-1710.

94. Bronner-Fraser, M. (1995) Origins and developmental potential of the neural crest. Exp. Cell

Res. 218, 405-417. 95. Dickinson, M., Selleck, M., McMahon, A. and Bronner-Fraser, M. (1995) Dorsalization of the

neural tube by the non-neural ectoderm. Development 121, 2099-2106.

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96. Marcelle, C., Wolf, J. and Bronner-Fraser, M. (1995) The in vivo expression of the FGF

receptor FREK mRNA on avian myoblasts suggests a role in muscle growth and differentiation. Devl. Biol. 172, 100-114.

97. Bronner-Fraser, M. (1995) Origin of the avian neural crest. Stem Cells 13, 640-646. 98. Krull, C.E., Collazo, A., Fraser, S.E. and Bronner-Fraser, M. (1995) Segmental migration of

trunk neural crest: time-lapse analysis reveals a role for PNA-binding molecules. Development 121, 3733-3743.

99. Artinger, K., Fraser, S. and Bronner-Fraser, M. (1995) Dorsal and ventral cell types can arise

from common neural tube progenitors. Devl. Biol. 172, 591-601. 100. Sechrist, J., Nieto, A., Zamanian, R. and Bronner-Fraser, M. (1995) Regulative response of

the cranial neural tube after neural fold ablation: spatiotemporal nature of neural crest generation and up-regulation of Slug Development 121, 4103-4135.

101. Bronner-Fraser, M. (1995) Hepatocyte Growth Factor/Scatter Factor (HGF/SF) in early

development: evidence for a role in neural induction. Trends in Genetics 11, 423-425. 102. Kenny, D., Bronner Fraser, M. and Marcelle, C. (1995) The receptor tyrosine kinase QEK5

mRNA is expressed in a gradient within the neural retina and the tectum. Devl. Biol. 172, 708-716

103. Kil, S.H. and Bronner-Fraser, M. (1996) Expression of the avian a7 integrin in developing

nervous system and myotome. Int. J. of Devel. Neurosci. 14, 181-190. 104. Perris, R., Perissinotto, D., Pettway, Z., Bronner-Fraser, M., Morgelin, M. and Kimata, K.

(1996) Inhibitory effect of PG-H/aggrecans and PG-M/versican on avian neural crest cell migration. FASEB J. 10, 293-301.

105. Selleck, M.A.J, Hayamizu, T.F., Bronner-Fraser, M. and Bryant, S.V. (1996) Digit induction by

Hensen's node and notochord does not activate RAR-b2 expression. Devl. Biol. 173, 318-26. 106. Saldivar, J., Krull, C.E., Krumlauf, R. and Bronner-Fraser, M. (1996) Rhombomere of origin

determines autonomous versus environmentally-regulated expression of Hox a3 in the avian embryo. Development 122, 895-904.

107. Pettway, Z., Domowicz, M., Schwartz, N.B. and Bronner-Fraser, M. (1996) Age-dependent

inhibition of neural crest migration by the notochord correlates with alterations in the S103L chondroitin sulfate proteoglycan. Exp. Cell Res. 225, 195-206.

108. Selleck, M.A.J., and Bronner-Fraser, M. (1996) The genesis of avian neural crest cells: A

classic embryonic induction. Proc. Natl. Acad. Sci. 93, 9352-9357.. 109. Kil, S.H., Lallier, T., and Bronner-Fraser, M. (1996) Inhibition of cranial neural crest adhesion in

vitro and migration in vivo using antisense oligonucleotides. Devl. Biol. 179, 91-101.

110. Saldivar, J.R., Sechrist, J., Krull, C.E., and Bronner-Fraser, M. (1997) Dorsal hindbrain ablation results in rerouting of neural crest migration and changes in gene expression, but normal hyoid development. Development 124, 2729-2739.

111. Krull, C.E., Lansford, R., Gale, N.W., Marcelle, C., Collazo, A., Yancopoulos, G., Fraser, S.E.,

Bronner-Fraser, M. (1997) Interactions between Eph-related receptors and ligands confer rostrocaudal polarity to trunk neural crest migration. Current Biology 7, 571-580.

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112. Baker, C.V. H., Bronner-Fraser, M., Le Douarin, N.M., and Teillet, M.A. (1997) Early- and late-

migrating cranial neural crest populations have equivalent developmental potential in vivo. Development 124, 3077-3087.

113. Marcelle, C., Stark, M. and Bronner-Fraser, M. (1997) Coordinate BMP, Wnt, Shh and Noggin

signals mediate patterning of the dorsal somite. Development 124, 3955-3963.

114. Stark, M., Bronner-Fraser, M., Sechrist, J., and Marcelle, C., (1997) Neural tube/ectoderm interactions are required for trigeminal placode formation Development 124, 4287-4295.

115. Baker, C.V.H. and Bronner-Fraser, M. (1997) The origins of the neural crest. Part I: Embryonic

induction. Mechanisms of Development 69, 3-11. 116. Baker, C.V.H. and Bronner-Fraser, M. (1997) The origins of the neural crest. Part II: An

evolutionary perspective. Mechanisms of Development 69, 13-29. 117. Bronner-Fraser M. and Fraser SE. (1997) Differentiation of the vertebrate neural tube. Current

Opinion in Cell Biology 9, 885-91. 118. Krull, C.E. and Bronner-Fraser, M. (1998) "Neural Crest Migration" in Motion Analysis of Living

Cells. John Wiley and Sons, N.Y., pp. 221-235. 119. LaBonne, C. and Bronner-Fraser, M. (1998) Neural crest cell induction in Xenopus: Evidence

for a two-signal model. Development 125, 2403-2414. 120. Artinger, K.B., N. Fedtsova, J. M. Rhee, M. Bronner-Fraser and E. Turner, (1998) Placodal

origin of Brn-3-expressing cranial sensory neurons. J. Neurobiology 36, 772-585. 121. Ruffins, S., Artinger, K.B., and Bronner-Fraser, M., (1998) Early migrating neural crest cells can

form ventral neural tube derivatives when challenged by transplantation. Devel. Biol. 203, 295-304.

122. Martinsen, B. and Bronner-Fraser, M., (1998) Neural crest cell fate is regulated by the helix-

loop-helix transcriptional regulator, Id2. Science 281, 988-991. 123. Kil,S. H. C. E. Krull, G. Cann, D. Clegg and M. Bronner-Fraser. (1998) The �4 subunit of

integrin is essential for neural crest migration Devel. Biol. 202, 29-42. 124. LaBonne, C. and Bronner-Fraser, M. (1998) Induction and patterning of the neural crest, a stem

cell-like precursor population. J. Neurobiol. 36, 175-189. 125. Selleck, M.A.J., Garcia-Castro, M., Artinger, K.B. and Bronner-Fraser, M (1998) Effects of Shh

and noggin on neural crest formation demonstrate that BMP is required in the neural tube but not ectoderm. Development 125, 4919-4930.

126. Sechrist, J., Wolf, J. and Bronner-Fraser, M. (1998) Age-dependent neurotransmitter plasticity

of ciliary ganglion neurons: Transplanted neurons re-enter the cell cycle. Molecular and Cellular Neuroscience 12, 311-323.

127. Baker, C.S. Stark, M., Marcelle, C. and Bronner-Fraser, M. (1999) Competence, specification

and induction of Pax-3 in the trigeminal placode. Development 126, 147-156. 128. Groves, A.K. and Bronner-Fraser, M. (1999) Neural Crest Diversification. Current Topics in

Developmental Biology 43, 221-258.

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129. Bronner-Fraser, M. (1999) Rostrocaudal differences within the somites confer segmental pattern trunk neural crest migration. Current Topics in Developmental Biology 47, 203-220.

130. Ahlgren, S., and Bronner-Fraser, M. (1999) Inhibition of Sonic hedgehog signaling in vivo

results in craniofacial neural crest cell death. Current Biology 9, 1304-1314 131. Bronner-Fraser M. (2000) Rostrocaudal differences within the somites confer segmental

pattern to trunk neural crest migration. Curr Top Dev Biol. 47, 279-96 132. Garcia-Castro, M. and Bronner-Fraser, M. (1999) Induction and differentiation of the neural

crest. Current Opinion in Development and Genetics. 11, 695-698. 133. Marcelle, C., Ahlgren, S. and Bronner-Fraser, M. (1999) In vivo regulation of somite

development by sonic hedgehog. Devel. Biol. 214:277-287. 134. LaBonne C., Bronner-Fraser, M. (1999) Molecular mechanisms of neural crest formation. Annu

Rev Cell Dev Biol. 15, 81-112. 135. Ruffins, S. and Bronner-Fraser, M. (2000) A critical period for conversion of ectodermal cells to

a neural crest fate. Devel. Biol. 218, 13-20. 136. Groves, A. and Bronner-Fraser, M. (2000) Induction of the otic placode I: Competence,

specification and commitment of placodal ectoderm. Development 127, 3489-3499. 137. Kulesa, P., Bronner-Fraser, M., and Fraser, S.E. (2000) In ovo time lapse analysis after dorsal

neural tube ablation show rerouting of chick hindbrain neural crest. Development 127, 3045-3056.

138. Baker, C. and Bronner-Fraser, M. (2000) Establishing neuronal identity in vertebrate

neurogenic placodes. Development 127, 2843-2852 139. Bronner-Fraser M. and Sternberg, P.W. (2000) Pattern formation and developmental

mechanisms. The cell biological basis of inductive signaling. Curr Opin Genet Dev. 10, 347-9. 140. LaBonne, C. and Bronner-Fraser, M. (2000) In Xenopus, Snail-related transcriptional

repressors are required for both the induction of the neural crest and its subsequent migration. Devel. Biol. 221, 195-205.

141. Perissinotto, D., Iacopetti, P., Bellina, I., Doliana, R., Colombatti, A., Pettway, Z., Bronner-

Fraser, M., Sinomura, T., Kimata, K., Morgelin, M., Lofberg, J., and Perris, R. (2000) Neural crest cell migration is diversely governed by permissive and nonpermissive hyaluronin-binding proteoglycans: PG-M/versicans and aggregans. Development 127, 2823-2842.

142. Linker, C., Bronner-Fraser, M. and Mayor, R. (2000) Relationship between gene expression

domains of Xsnail, Xslug and Xtwist to cell movement in the prospective neural crest of Xenopus. Devel. Biol. 224, 215-225.

143. Moreno, T. and Bronner-Fraser, M. (2000) “Neural Crest Cells: Precursors to the peripheral

nervous system” in Stem Cells (in press). 144. Epperlein, H.H., Meulemans, D., Bronner-Fraser, M. and Selleck, M.J.S. (2000) Analysis of

cranial neural crest migratory pathways in axolotl using cell markers, homotopic and heterotopic transplantation. Development 127, 2751-2761.

145. Selleck, M. and Bronner-Fraser, M. (2000) Avian neural crest cell fate decisions: A diffusible

signal mediates induction of neural crest by the ectoderm. Int. J. of Devel. Biol. 18, 621-627.

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146. Basch, M., Selleck, M., and Bronner-Fraser, M. (2000) Timing and competence of neural crest formation. Develop. Neurosci. 22, 217-227.

147. Barembaum, M., Moreno, T., LaBonne, C., Sechrist, J., and Bronner-Fraser, M. (2000) Noelin-

1 is a secreted glycoprotein involved in generation of neural crest. Nature Cell Biology 2, 219-225.

148. Garcia-Castro, M., Vielmetter, E., and Bronner-Fraser, M. (2000) N-cadherin, a cell adhesion

molecule involved in establishment of left-right asymmetry. Science 288, 1047-1051. 149. Baker, C. and Bronner-Fraser, M. (2001) Vertebrate cranial placodes: I. Embryonic

induction. Dev. Biol. 232, 1-61. 150. Nellemann, C., de Bellard, M., Barembaum, M., Laufer, E., Bronner-Fraser, M. (2001) Excess

lunatic fringe causes cranial neural crest over-proliferation Dev. Biol. 235, 121-130. 151. Knecht, A. and Bronner-Fraser, M. (2001) MOX, a gene with homology to dopamine �-

hydroxylase, is expressed in the neural crest throughout early development. Devel. Biol. 234, 365-375.

152. Moreno, T. and Bronner-Fraser, M. (2001) The secreted glycoprotein Noelin promotes

neurogenesis in Xenopus. Devel. Biol. 240, 340-360. 153. Kee, Y. and Bronner-Fraser, M. (2001) Temporally and spatially restricted expression of the

helix-loop-helix transcriptional regulator Id1 during avian embryogenesis . Mech. of Devel. 109, 331-335.

154. Kee, Y. and Bronner-Fraser, M. (2001) The transcriptional regulator Id3 is expressed in cranial

sensory placodes during early avian embryonic development. Mech. of Devel. 109, 337-340. 155. Kee, Y. and Bronner-Fraser, M. (2001). Id4 expression and its relationship to other Id genes

during avian embryonic development. Mech. of Devel. 109, 341-345. 156. McCauley, D. and Bronner-Fraser, M. (2002) Conservation of Pax gene expression in

ectodermal placodes of the lamprey. Gene 287, 129-139. 157. Kious, B., Baker, C., Bronner-Fraser, M. and Knecht, A. (2002) Identification and

characterization of a calcium channel gamma subunit expressed in differentiating neurons and myoblasts. Devel Biol. 243, 249-259.

158. Ahlgren, S and Bronner-Fraser, M. (2002) Recycling signaling molecules during development.

Nature Neurosci. 5, 87-88. 159. García-Castro, M., Marcelle, C. and Bronner-Fraser, M. (2002) Ectodermal Wnt function as a

neural crest inducer. Science 297, 848-851. 160. Bronner-Fraser, M. (2002) Molecular analysis of neural crest formation. J Physiol. 96, 3-8. 161. Knecht, A. and Bronner-Fraser, M. (2002) Induction of the neural crest: a multigene process.

Nature Reviews Genetics 3, 453-461. 162. Moreno, T. and Bronner-Fraser, M. (2002) Neural expression of mouse Noelin-1/2 and

comparison with other vertebrates. Mechanisms of Development 119, 121. 163. DeBellard, M.E., Ching, W., Gossler, A. and Bronner-Fraser, M. (2002) Disruption of segmental

neural crest migration and ephrin expression in Delta-1 null mice Devel. Biol. 249, 121-130.

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164. Ahlgren, S., Thakur, V. and Bronner-Fraser, M. (2002) Sonic hedgehog rescues neural crest cell death induced by fetal alcohol syndrome. Proc. Natl. Acad. Sci. 99, 10476-81.

165. Baker, C., Stark, M., and Bronner-Fraser, M. (2002) Pax3-expressing ophthalmic trigeminal

placode cells are committed to a cutaneous sensory neuron fate. Devl. Biol. 249, 219-236. 166. Meulemans, D. and Bronner-Fraser, M. (2002) Amphioxus and lamprey AP-2 genes:

implications for neural crest evolution and migration patterns. Development 129, 4953-62. 167. Gammill, L. and Bronner-Fraser, M. (2002) A genomic analysis of neural crest induction.

Development 129, 5731-41. 168. Lee, V., Sechrist, J., Bronner-Fraser, M. and Nishi, R. (2002) Neuronal differentiation from post-

mitotic precursors in the ciliary ganglion Devel. Biol. 252, 312-323. 169. Peters, J., Sechrist, J., Luetolf, S., Loredo, G. and Bronner-Fraser, M. (2003) Spatial expression of the

alternatively spliced EIIIB and EIIIA segments of fibronectin in the early chicken embryo. Cell Communication and Adhesion 9, 221-38.

170. Schubert, M., Meulemans, D. Bronner-Fraser, M.,Holland, L.Z. and Holland, N.D. (2003) Differential

mesodermal expression of two amphioxus MyoD family members (AmphiMRF1 AND AmphiMRF2). Mechanisms of Devel.: Gene Expression Patterns. 3, 199-202.

171. Ahlgren, S., Vogt, P. and Bronner-Fraser, M. (2003) Excess FoxG1 causes overgrowth of the

neural tube. J. Neurobiology 57, 337-349. 172. McCauley, D. and Bronner-Fraser, M. (2003) Neural crest contributions to the lamprey head.

Development 130, 2317-2327. 173. DeBellard, M., Rao, Y. and Bronner-Fraser, M. (2003) Dual function of Slit2 in repulsion and

enhanced migration of trunk neural crest cells. J. Cell Biol. 162, 269-280. 174. Lee, V., Sechrist, J., Luetolf, S. and Bronner-Fraser, M. (2003) Both neural crest and placode

contribute to the ciliary ganglion and oculomotor nerve. Devl Biol. 263, 176-190. 175. Hemmati, HD, Nakano, Lazareff, Masterman, Geschwind, Bronner-Fraser,M. Kornblum, H.

(2003) Cancerous stem cells can arise from human pediatric brain tumors. Proc. Natl. Acad. Sci. USA 100, 15178-83.

176. Gammill, L. and Bronner-Fraser, M. (2003) Neural crest specification: migrating into genomics.

Nature Reviews Neurosci. 4, 795-805. 177. Meulemans, D., D. McCauley, and M. Bronner-Fraser (2003) Id gene expression in amphioxus

and lamprey highlights the role of genetic co-option during neural crest evolution. Devl. Biol. 264, 430-42.

178. Cerny, R. Meulemans, M., Berger, J. Wilsch-Brauminger, M., Kurth, T., Bronner-Fraser, M. and

Epperlein, H.H. (2004) Cranial neural crest migration and pharyngeal arch morphogenesis in axolotl. Dev. Biol. 266, 252-69.

179. Venters, S.J., Argent, R.E., Deegan, F.M., Wong, T.S., Tidyman, W.E., Marcelle, C., Bronner-

Fraser, M., Ordahl, C.P. (2004) Limb muscle precursor cells do not undergo precocious terminal differentiation when isolated from lateral inhibitory signals Devl. Dynamics 229, 591-9.

180. Chen, Y., Gutmann, C., Haipek, B., Martinsen, B., Bronner-Fraser, M. and Krull, C. (2004)

Characterization of chicken Nf2/merlin indicates potential roles in growth regulation and cell migration. Devl. Dynamics 229, 541-54.

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181. Barembaum, M. and Bronner-Fraser, M. (2004) A novel chicken spalt gene expressed in

branchial arches reduces neurogenic potential of the cranial neural crest. Neuron Glia 1, 57-63. 182. Lwigale, P.Y., Conrad, G. and Bronner-Fraser, M., (2004) Graded potential of neural crest to

form cornea, sensory neurons and cartilage along the rostrocaudal axis. Development 131, 1979-1991.

183. Bhattacharyya. S., Bailey, AP, Bronner-Fraser, M, and Streit, A. (2004) Pax6, Dlx5 and cell

sorting during olfactory and lens placode development: parallels between vertebrates and Drosophila Devl. Biol. 271, 403-414.

184. Cerny, R., Lwigale, P., Ericsson, R., Meulemans, D.,Epperlein, H.H. and Bronner-Fraser, M.

(2004) Mandibular arch morphogenesis and the origin of jaws: new interpretation of “maxillary” and “mandibular” Devl. Biol. 276, 225-236.

185. McCabe, K., Manzo, A., Gammill, L. and Bronner-Fraser, M. (2004) Discovery of genes

implicated in placode formation. Devl. Biol. 24, 462-477. 186. McCauley, D. and Bronner-Fraser, M. (2004) Conservation and Divergence of BMP24 Genes in

the Lamprey: Expression and Phylogenetic Analysis Suggest a Single Ancestral Gene. Evolution and Development 6, 411-422.

187. Coles, E., Christiansen, J, Economou, A, Bronner-Fraser, M and Wilkinson, D.G. (2004) A

vertebrate crossveinless-2 homologue modulates BMP activity and neural crest cell migration Development 131, 5309-5317.

188. Meulemans, D. and Bronner-Fraser, M. (2004). Gene-Regulatory Interactions in Neural Crest

Development and Evolution Developmental Cell 7, 291-299. 189. Bhattycharyya, S. and Bronner-Fraser, M. (2004) Hierarchy of regulatory events in sensory

placode development Current Opinions in Development and Genetics 14, 520-526. 190. McKeown, SJ, Lee, VM, Bronner-Fraser, M, Newgreen , DF and Farlie, PG (2005) Sox10

induces neural crest from all dorsoventral levels of the neural tube and maintains an undifferentiated state. Devl. Dynamics 233, 430-444.

191. Lee, V., Bronner-Fraser, M., and Baker, C.V. (2005) Restricted response of mesencephalic

neural crest to sympathetic differentiation signals in the trunk. Dev. Biol. 278, 175-92. 192. Bok J, Bronner-Fraser M, Wu DK.(2005) Role of the hindbrain in dorsoventral but not

anteroposterior axial specification of the inner ear. Development 132, 2115-2124. 193.Kee, Y., and Bronner-Fraser, M. (2005) To proliferate or to die: role of Id3 in cell cycle

progression and survival of neural crest progenitors. Genes and Development 19, 744-55. 194. Barembaum M, Bronner-Fraser M. (2005) Early steps in neural crest specification. Semin Cell

Dev Biol. 16, 642-646. 195. Meulemans D, and Bronner-Fraser M. (2005) Central role of gene cooption in neural crest

evolution. J Exp Zool. 196. deBellard, ME, Bronner-Fraser M. (2005) Neural crest migration methods in the chicken

embryo. Methods Mol Biol. 294, 247-67. 197. Lwigale, P., and Bronner-Fraser, M. (2005) Corneal keratocytes retain neural crest progenitor

cell properties. Dev. Biol. 288, 284-293.

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198. Moreno, M. & Bronner-Fraser, M. (2005) Noelins modulate the timing of neuronal differentiation

during development Dev. Biol. 288, 234-247. 199. Taneyhill, L. & Bronner-Fraser, M. (2005) Dynamic alterations in gene expression after Wnt-

mediated neural crest induction. Mol. Biol. Cell. 16, 5283-93. 200. Coles, E.G., Gammill, L.S., Miner J.H. and Bronner-Fraser M. (2006) Abnormalities in neural

crest cell migration in laminin 5 mutant mice. Dev. Biol. 289, 434-447. 201. Gammill, L., Gonzalez, C., Gu, C. and Bronner-Fraser, M. (2006) Guidance of trunk neural crest

migration requires Neuropilin-2/Semaphorin3F signaling. Development 133, 99-106. 202. Coles, E.G., Gammill, L.S., Miner J.H. and Bronner-Fraser M. (2006) Abnormalities in neural

crest cell migration in laminin 5 mutant mice. . Dev. Biol. 289, 434-447. 203. Bailey, AP, Bhattacharyya, S., Bronner-Fraser2 M and Streit, A (2006) Lens specification is the

ground state of all sensory placodes, from which FGF promotes olfactory identity Devel. Cell 11, 505-17.

204. McCauley, D. and Bronner-Fraser, M. (2006) Importance of SoxE in neural crest development

and evolution of the pharynx. Nature 441, 750-752. 205. Basch, M., Bronner-Fraser, M. and Garcia-Castro, M. (2006) Specification of neural crest

occurs during gastrulation and requires Pax7. Nature 441, 218-222. 206. Sauka-Spengler T, Bronner-Fraser, M. (2006) Development and evolution of the migratory

neural crest: a gene regulatory perspective. Curr Opin Genet Dev., 16, 360-6. 207. Gammill, L., Gonzales, C., and Bronner-Fraser, M. (2006) Neuropilin 2/semaphorin 3F

signaling is essential for cranial neural crest migration and trigeminal ganglion condensation. J. Neurobiology 67, 47-56.

208. Epperlein, HH, Selleck, MAJ, Meulemans, D, Mchedlishvili, L, Cerny, R, Sobkow, L, and

Bronner-Fraser, M (2006) Migratory patterns and developmental potential of trunk neural crest cells in the axolotl embryo. Dev. Dyn. 67, 47-56.

209. Yu, J-K, Satou, Y., Holland, N.D., Shin-I, T., Kohara, Y., Satoh, N., Bronner-Fraser, M.,

Holland, L.Z. (2007) Axial patterning in cephalochordates and the evolutionary origin of the gastrula organizer. Nature 445, 613-617.

210. Kee, Y., Hwang, B-J, Sternberg, PW, and Bronner-Fraser, M. (2007) Evolutionary conservation

of cell migration genes: from nematode neurons to vertebrate neural crest. Genes and Development 15, 391-396.

211. Taneyhill, L., Coles, E., and Bronner-Fraser, M., (2007) Snail2 directly represses cadherin6B

during epithelial-to-mesenchymal transitions of the neural crest. Development 134, 1481-1490. 212. Lwigale, PY, Bronner-Fraser M. (2007) Lens-derived Semaphorin3A regulates sensory

innervation of the cornea. Dev. Biol. 15, 750-759. 213. Sauka-Spengler, T., Meulemans, D., Bronner-Fraser, M. (2007) Ancient evolutionary origin of

the neural crest gene regulatory network. Dev. Cell 13, 405-420.

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214. Trinh, L, McCutchen, M., Bronner-Fraser, M., Fraser, S.E., Bumm, L.A., McCauley, D.W. (2007) Fluorescent in situ hybridization employing the conventional NBT/BCIP chromogenic stain. Biotechniques 42, 756-759.

215. Meulemans, D., and Bronner-Fraser, M. (2007)The amphioxus SoxB family: implications for the

evolution of vertebrate placodes. Int J Biol Sci. 3, 356-64. 216. Meulemans, D., and Bronner-Fraser, M. (2007) Insights from amphioxus into evolution of

vertebrate cartilage. PLoS One. 2, e787 217. McCabe, K., Shiau, C. and Bronner-Fraser, M. (2007) Identification of candidate secreted

factors involved in trigeminal placode induction. Dev. Dynamics 236, 2925-2935 218. Barembaum, M. and Bronner-Fraser, M. (2007) Spalt4 mediates ectodermal invagination and

otic placode gene expression. Development 134, 3805-3814 219. Coles, E., Taneyhill, L. and Bronner-Fraser, M. (2007) A critical role for Cadherin6B in

regulating avian neural crest emigration. Dev. Biol. 312, 533-544 220. Adams, M., Gammill, L., and Bronner-Fraser, M. (2008) Discovery of transcription factors and

other candidate regulators of neural crest development, Dev. Dynamics 237, 1021-1033. 221. Nikitina, N., Sauka-Spengler, T. and Bronner-Fraser, M. (2008) Dissecting early regulatory

relationships in the lamprey neural crest gene regulatory network. Proc. Natl. Acad. Sci. USA 105, 20083-8.

222. Bhattacharyya, S, and Bronner-Fraser, M. (2008) Competence, specification and commitment

to an olfactory sensory placode fate. Development 135, 4165-77 223. Shiau. C.E., Lwigale, P.Y., Das, R.M., Wilson, S., and Bronner-Fraser, M. (2008) Robo2/Slit1

dependent cell-cell interactions mediate assembly of the trigeminal ganglion. Nature Neurosci. 11: 269-276

224. McCabe, K., and Bronner-Fraser, M. (2008) Essential role for PDGF signaling in ophthalmic

trigeminal placode Induction. Development 135, 1863-1874.. 225. Coles, E., Lawlor, E., Bronner-Fraser, M. (2008) EWS-FLI1 causes neuroepithelial defects and

abrogates emigration of neural crest stem cells. Stem Cells 26, 2237-2244. 226. Yu, J.K., Meulemans, D., McKeown, S. and Bronner-Fraser, M. (2008) Insights from the

amphioxus genome on the origin of vertebrate neural crest. Genome Res 18, 1127-32 227. Putnam, N. et al. (2008) The amphioxus genome and the evolution of the chordate karyotype.

Nature 453, 1064-1071. 228. Holland, L., et al. (2008) The amphioxus genome illuminates vertebrate origins and

cephalochordate biology. Genome Res. 18, 1100-1111. 229. Sauka-Spengler, T. and Bronner-Fraser, M. (2008) A gene regulatory network orchestrates

neural crest formation. Nat. Rev. Mol. Cell Biol. 9, 557-568. 230. Khudyakov J, Bronner-Fraser M.(2009) Comprehensive spatiotemporal analysis of early chick

neural crest network genes. Dev Dyn. 238,716-723. 231. Nikitina N, Sauka-Spengler T, Bronner-Fraser M. (2009) Gene regulatory networks in neural

crest development and evolution. Curr Top Dev Biol. 86, 1-14.

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232. Sauka-Spengler T, Bronner-Fraser M. (2008) Evolution of the neural crest viewed from a gene

regulatory perspective. Genesis. 46, 673-82. 233. Sauka-Spengler T, Bronner-Fraser M. (2008) Insights from a sea lamprey into the evolution of

neural crest gene regulatory network. Biol Bull. 214, 303-14. 234. Jiang X, Gwye Y, McKeown SJ, Bronner-Fraser M, Lutzko C, Lawlor ER.(2009) Isolation and

characterization of neural crest stem cells derived from in vitro differentiated human embryonic stem cells. Stem Cells Dev. (in press)

235. Ezin, A.,M, Fraser, S.E. and Bronner-Fraser, M., (2009) Fate map and morphogenesis of

presumptive neural crest and dorsal neural tube. Dev. Biol. 330, 221-236. 236. McCabe KL, Sechrist JW, Bronner-Fraser M.(2009) Birth of ophthalmic trigeminal neurons

initiates early in the placodal ectoderm. J Comp Neurol. 2009, 514, 161-73. 237. Acloque H, Adams MS, Fishwick K, Bronner-Fraser M, Nieto MA. (2009) Epithelial-

mesenchymal transitions: the importance of changing cell state in development and disease. J Clin Invest. 119, 1438-49.

238. Shiau, C. and Bronner-Fraser, M. (2009) N-cadherin acts in concert with Slit1-Robo2 signaling

in regulating aggregation of placode-derived cranial sensory neurons. Development 136, 4155-4164.

239. Barembaum, M. and Bronner-Fraser, M. (2009) Pax2 and Pea3 synergize to activate a novel

regulatory enhancer for spalt4 in the developing ear. Dev. Biol. 40, 222-31PMID: 19913005. 240. Lwigale, P. and Bronner-Fraser, M. (2009) Semaphorin3A/neuropilin-1 signaling acts as a

molecular switch regulating neural crest migration during cornea development. Dev. Biol. (in press). PMID: 19833121.

241. Nie, S., Kee, Y, and Bronner-Fraser, M. (2009) Myosin-X is critical for migratory ability of

Xenopus cranial neural crest cells. Dev. Biol. 335, 132-42. PMID: 19712673) 242. Jiang,X, Gwye,Y, McKeown, SJ Bronner-Fraser, M., Lutzko, C., and Lawlor, ER (2009)

Isolation and Characterization of Neural Crest Stem Cells Derived From In Vitro–Differentiated Human Embryonic Stem Cells. Stem Cells and Development 18, 1059-69.

243. Strobl-Mazzulla, Sauka-Spengler, T and Bronner-Fraser, M. (2010) Histone demethylase

JmjD2A regulates neural crest specification. Dev. Cell 19, 460-8. 244. Ezin AM, Sechrist JW, Zah A, Bronner M, Fraser SE. (2010) Early regulative ability of the

neuroepithelium to form cardiac neural crest. Dev. Biol. 349, 238-49 245. Cerny, R., Cattell, M., Sauka-Spengler T., Bronner M., Yu F., Medeiros, DM (2010) Cryptic

patterning in the lamprey pharynx supports a new model for the evolution of the vertebrate jaw. PNAS. 107, 17262-7.

246. Betancur, P., Bronner-Fraser, M. and Sauka-Spengler, T. (2010) Genomic code for Sox10, a

key regulatory enhancer for cranial neural crest. Proc. Natl. Acad. Sci. USA 107, 3570-5 247. Curchoe CL, Maurer J, McKeown SJ, Cattarossi G, Cimadamore F, Nilbratt M, Snyder EY,

Bronner-Fraser M, Terskikh AV. (2010) Early acquisition of neural crest competence during hESCs neuralization. PLoS One. 5. 13890.

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248. Shiau CE, Hu N, Bronner-Fraser M.(2010) Altering Glypican-1 levels modulates canonical Wnt signaling during trigeminal placode development. Dev Biol 348, 107-18

249. Fraser GJ, Cerny R, Soukup V, Bronner-Fraser M, Streelman JT. (2010) The odontode

explosion: the origin of tooth-like structures in vertebrates. Bioessays 32, 808-17. 250. Betancur P, Bronner-Fraser M, Sauka-Spengler T. (2010) Assembling neural crest regulatory

circuits into a gene regulatory network. Annu Rev Cell Dev Biol. 26:581-603. PMID: 19575671 251. McCabe KL, Bronner-Fraser M. (2011) Tetraspanin, CD151, is required for maintenance of

trigeminal placode identity. J Neurochem. 2011 252. Sobreira TJ, Marlétaz F, Simões-Costa M, Schechtman D, Pereira AC, Brunet F, Sweeney S,

Pani A, Aronowicz J, Lowe CJ, Davidson B, Laudet V, Bronner M, de Oliveira PS, Schubert M, Xavier-Neto J. (2011) Structural shifts of aldehyde dehydrogenase enzymes were instrumental for the early evolution of retinoid-dependent axial patterning in metazoans. Proc Natl Acad Sci USA108, 226-31

253. Nie S, Kee Y, Bronner-Fraser M. (2011) Caldesmon regulates actin dynamics to influence

cranial neural crest migration in Xenopus. Mol Biol Cell. 22, 3355-65 254. Nikitina, N., Tong, L., and Bronner, ME (2011) Ancestral network module regulating prdm1

expression in the lamprey neural plate border. Devl. Dyn. 240, 2265-71 255. Jayasena, C., Trinh, L. and Bronner, M.E. (2011) Live imaging of endogenous Periodic

tryptophan protein 2 gene homologue during zebrafish development. Devl. Dyn. 240, 2578-83 256. Cimadamore F, Fishwick K, Giusto E, Gnedeva K, Cattarossi G, Miller A, Pluchino S, Brill LM,

Bronner-Fraser M, Terskikh AV. (2011) Human ESC-derived neural crest model reveals a key role for SOX2 in sensory neurogenesis. Cell Stem Cell. 2011 May 6;8(5):538-51.

257. Betancur P, Sauka-Spengler T, Bronner M. (2011) A Sox10 enhancer element common to the

otic placode and neural crest is activated by tissue-specific paralogs. Development. 138, 3689-98. 258. Jayasena CS, Trinh LA, Bronner M. (2011) Live imaging of endogenous Collapsin response

mediator protein-1 expression at subcellular resolution during zebrafish nervous system development. Gene Expr Patterns.11, 395-400.

259. Trinh le A, Hochgreb T, Graham M, Wu D, Ruf-Zamojski F, Jayasena CS, Saxena A, Hawk R,

Gonzalez-Serricchio A, Dixson A, Chow E, Gonzales C, Leung HY, Solomon I, Bronner-Fraser M, Megason SG, Fraser SE. (2011) A versatile gene trap to visualize and interrogate the function of the vertebrate proteome. Genes Dev., 25, 2306-20

260. Häming D, Simoes-Costa M, Uy B, Valencia J, Sauka-Spengler T, Bronner-Fraser M. (2011)

Expression of sympathetic nervous system genes in Lamprey suggests their recruitment for specification of a new vertebrate feature. PLoS One. 6, e26543.

261. Parker, H.J., Piccinelli, P., Sauka-Spengler, T., Bronner, M. and Elgar, G. (2011) Ancient Pbx-

Hox signatures define hundreds of vertebrate developmental enhancers. BMC Genomics, 12:637. 262. Uy, B., Simoes-Costa, M., Sauka-Spengler, T., and Bronner, M.E. (2012) Expression of Sox

family genes in early lamprey development. International Journal of Developmental Biology 56, 377-83

263. Fishwick, K., Kim, E., and Bronner, M.E. (2012) ILF-3 is a regulator of neural plate border

marker Zic1 in chick embryos. Developmental Dynamics 241, 1325-32.

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264. Kerosuo L, Bronner-Fraser M. (2012) What is bad in cancer is good in the embryo: importance

of EMT in neural crest development. Semin Cell Dev Biol. 23, 320-32 265. Jayasena C.S., and Bronner, M.E. (2012) Rbms3 functions in craniofacial development by

post-transcriptionally modulating TGFß signaling. J. Cell Biol. 199, 453-66 266. Ishii, M., Arias, A., Liu. L., Chen Y.B., Bronner M.E., Maxson, R.E. (2012) A stable cranial neural crest

cell line from mouse. Stem Cells and Development 21(17):3069-80. 267. Fishwick, K., Bronner, M.E. and Taneyhilll, L. (2012) The tight junction protein claudin-1

regulates cranial neural crest cell emigration. Mechanisms of Development 129, 275-83 268. Strobl-Mazzulla PH, Bronner ME. (2012) Epithelial to mesenchymal transition: New and old

insights from the classical neural crest model. Semin Cancer Biol. 22(5-6): 411-6 269. Strobl-Mazzulla, P. and Bronner, M.E. (2012) A PHD12-Snail2 repressive complex

epigenetically mediates neural crest epithelial to mesenchymal transition. J. Cell Biol. 198, 999-1010.

270. Hu, N., Strobl-Mazzulla, P., Sauka-Spengler,T., Bronner,M.E. (2012) DNA methyltransferase3A

as a molecular switch mediating the neural tube to neural crest fate transition. Genes and Development 26, 2380-5.

271. Simoes-Costa, M., McKeown, S., Tan-Cabugoa, J., Sauka-Spengler, T. and Bronner, M.E.

(2012) Dynamic and differential regulation of stem cell factor FoxD3 in the neural crest is encrypted in the genome PLoS Genetics e1003142.

272. Hochgreb-Hägele, T., and Bronner, M.E. (2013) A novel FoxD3 gene trap line reveals neural

crest precursor movement and a role for FoxD3 in their specification. Dev. Biol. 375, 1-11. 273. McKinney, M.C., Fukatsu, K., Morrison, J. McLennan, R., Bronner, M.E., and Kulesa, P. (2013)

Evidence for dynamic rearrangements but lack of fate or position restrictions in premigratory avian trunk neural crest. Development 140, 820-30.

274. Rogers, C., Phillips, J. and Bronner, M.E. (2013) Role of transcription factor Elk3 in

progression from progenitor to definitive neural crest cell. Devl. Biol. 374, 255-63 275. Saxena, A., Peng, B. and Bronner, M.E. (2013) Sox10-dependent neural crest origin for

olfactory microvillous neurons. eLife e00336. 276. Smith, J. et al. (2013) The lamprey genome: illuminating vertebrate origins. Nature Genetics

45, 415-21. 277. Green SA, Bronner ME. (2012) Gene duplication and the early evolution of neural crest

development Sem. Cell Dev Biol. S1084-9521(12)00230-3

278. Chao JR, Bronner ME, Lwigale PY. (2013) Human Fetal Keratocytes Have Multipotent

Characteristics in the Developing Avian Embryo. Stem Cells Dev. 22, 2186-95.

279. Hochgreb-Hägele, T., Yin, C,, Koo, D., Bronner, M.E., and Stanier, D. (2013) Laminin1a

controls distinct steps during the establishment of digestive organ laterality. Development 140(13):2734-45.

280. Simões-Costa M, Bronner ME. (2013) Insights into neural crest development and evolution

from genomic analysis. Genome Res. 23, 1069-80

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281. Hochgreb-Hägele, T., Yin, C, Koo, D., Bronner, M.E., and Stanier, D. (2013) Laminin1a

controls distinct steps during the establishment of digestive organ laterality. Development 140(13):2734-45.

282. Barembaum, M. and Bronner, M. E. (2013) Identification and dissection of a key enhancer

mediating cranial neural crest specific expression of transcription factor, Ets-1. Dev. Biol. 382(2):567-75.

283. Bhattacharyya, S. and Bronner, M. E. (2013) Clonal analyses in the anterior pre-placodal

region: Implications for the early lineage bias of placodal progenitors Int. J. of Dev. 57, 753-7 284. Hochgreb-Hagele, T. and Bronner, M.E. (2013) Zebrafish stem/progenitor factor msi2b exhibits

two phases of activity mediated by different splice variants. Stem Cells 32, 558-71. 285. Rogers, C., Saxena, A., and Bronner, M. E. (2013) Sip1 mediates an E-cadherin-to-N-cadherin

switch during cranial neural crest EMT. J. Cell Biol. 203, 835-47. 286. Hu, N., Strobl-Mazzulla, P, Simoes-Costa, M., Sánchez Vásquez, E., and Bronner, M.E. (2014)

DNA methyltransferase 3B regulates duration of neural crest production via repression of Sox10. Proc.Natl.Acad.Sci. USA 11, 17911-6.

287. Parker, H., Bronner, M.E., Krumlauf, R. (2014) A Hox gene regulatory network for hindbrain segmentation is conserved to the base of vertebrates Nature 514, 490-3.

288. Simoes-Costa, M., Tan-Cabugao, J, Antoshechkin I, Sauka-Spengler, T., Bronner, M.E. (2014)

Transcriptome analysis reveals novel players in the cranial neural crest gene regulatory network. Genome Res. 24, 281-90

289. Wang K, Milkie DE, Saxena A, Engerer P, Misgeld T, Bronner ME, Mumm J, Betzig E. (2014)

Rapid adaptive optical recovery of optimal resolution over large volumes. Nat Methods 11, 625-8. 290. Hu, N, Strobl-Mazzulla, P., Bronner, M.E. (2014) Epigenetic regulation in neural crest

development. Dev. Biol. 396(2):159-168. 291. Ezin, M., Barembaum, M., Bronner, M.E. (2014) Stage-dependent plasticity of the anterior

neural folds to form neural crest. Differentiation 88, 42-50. 292. Saxena, A. and Bronner, M.E. (2014) A novel HoxB cluster protein expressed in the hindbrain

and pharyngeal arches. Genesis 52, 858-63. 293. Uy, B., Simoes-Costa, M., Koo, D.E., Sauka-Spengler, T., and Bronner, M.E. (2014)

Evolutionarily conserved role for SoxC genes in neural crest specification and neuronal differentiation. Dev. Biol. 397(2):282-92.

294. Kwon SH, Park OK, Nie S, Kwak J, Hwang BJ, Bronner ME, Kee Y. (2014) Bioinformatic

analysis of nematode migration-associated genes identifies novel vertebrate neural crest markers. PLoS One. 9(7):e103024.

295. Betancur P, Simões-Costa M, Sauka-Spengler T, Bronner ME. (2014) Expression and function

of transcription factor cMyb during cranial neural crest development. Mech. of Dev. 32:38-43. 296. Green SA, Bronner ME. (2014) The lamprey: A jawless vertebrate model system for examining

origin of the neural crest and other vertebrate traits Differentiation 87(1-2):44-51. 297. Maier EC, Saxena A, Alsina B, Bronner ME, Whitfield TT. (2014) Sensational placodes:

Neurogenesis in the otic and olfactory systems. Dev. Biol. 389, 50-67.

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298. Parker, H., Sauka-Spengler, T., Bronner, M.E. and Elgar, G. (2014) A reporter assay in lamprey

embryos reveals both functional conservation and elaboration of vertebrate enhancers. PLoS One 9(1): e85492.

299. Kerosuo, L., and Bronner, M.E. (2014) Biphasic influence of Miz1 on neural crest development

by regulating cell survival and apical adhesion complex formation in the developing neural tube. Mol. Biol. Cell 25, 347-55

300. Modrell, M., Hockman, D. Uy, B., Buckley, D., Sauka-Spengler, T, Bronner, M.E., Baker, C.V.H.

(2014) A fate-map for cranial sensory ganglia in the sea lamprey. Dev. Biol. 385, 405-16. 301. Butler, S., and Bronner, M.E. (2014) From classical to current: analyzing peripheral nervous

system and spinal cord lineage and fate. Dev. Biol. (in press). 302. Simões-Costa M, Bronner ME. (2015) Establishing neural crest identity: a gene regulatory

recipe. Development. 142, 242-257. 303. Hochgreb-Hagele, T. Koo, D., and Bronner, M.E. (2015) Znf385C mediates a novel p53-

dependent transcriptional switch to control timing of facial bone formation. Devel. Biol. (in press). 304. Green, S., Simoes-Costa, M., Bronner, M. (2014) Evolution of vertebrates: a view from the

crest. Nature 23;520(7548):474-82 305. Hochgreb-Hagele, T. Koo, D., Bronner, M.E. (2015) Znf385C mediates a novel p53-dependent

transcriptional switch to control timing of facial bone formation. Devel. Biol. 400(1):23-32. 306. Nie, S., and Bronner, M.E. (2015) Dual developmental role of transcriptional regulator Ets1 in

Xenopus cardiac neural crest versus heart mesoderm. Cardiovascular Research 106(1):67-75. 307. Simoes-Costa, M., Stone, M., and Bronner, M.E. (2015) Axud1 integrates Wnt signaling and

transcriptional inputs to drive neural crest formation. Devel. Cell (in press). BOOKS "Methods in Avian Embryology" edited by M. Bronner-Fraser, Methods in Cell Biology, Academic

Press, San Diego. TEACHING EXPERIENCE

Caltech 2006-present Bi117, Developmental Biology 1998-2005 Bi12, Introduction to Developmental Biology

2000-2002 Bi250B, Course Coordinator (with Dr. E. Rothenberg)

University of California, Irvine: 1986 - 1995 Biosci 231 (Developmental Biology Graduate Core) 1986 - 1994 Biosci 149 (Developmental Neurobiology) Biosci 103 (Developmental Biology) Biosci 144 (Cell Biology) 1983 - 1985 Medical Physiology 1985 Seminar on D'Arcy Thompson 1983 Growth and Differentiation 1980 Medical Embryology

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Woods Hole Marine Biological Laboratory and Cold Spring Harbor Courses

2010-2013 Faculty, Gene Regulatory Network Course, MBL 1997-2001 Co-Director, Embryology Course, MBL

1989-95; 2002-9, 2012-14 Faculty, Embryology Course, MBL 1992-1995 Lecturer, Molecular Biology of the Mouse Embryo, CSHL 1990, 1993 Lecturer, Developmental Neurobiology, CSHL UNIVERSITY SERVICE Caltech:

Chair, Athenaeum House Committee, 2006- 2013 Chair, Ad Hoc Committee on Mentoring and Retention of Faculty and Students, 2009 Member, Academic Policies Committee, 2007-present Faculty Advisor to BUSAC, 2001-present Division of Biology Curriculum Committee, 2003 – present Athenaneum Membership Committee, 2006 Committee on Quality of Student Life 2005 Women’s Center Advisory Committee, 2004 –2006 Committee on Institute Size, 2003-2005 House Renovation Committee, 2003-2004 Chair of the Faculty, 2001 – 2003 President’s Management Council, 2001-2003 Communications Task Force—2001-2003 Core Curriculum Committee—1999-present, Chair, 2000-2001 Athenaeum House Committee—2000-2003 Women Center Advisory Committee—1999-2001 Division of Biology, Graduate Admissions Committee--1996-1998, Chair, 1999 Vice President for Student Affairs Search Committee--1997 Graduate Student Quality of Life Committee--1998 Division of Biology, Seminar Committee—1997-2002 Division of Biology, Curriculum Committee—1999-2001

U.C. Irvine:

Chancellor's Committee on Affirmative Action--September 1992 - 1993 Committee on Education Policy--1989 Targets of Opportunity Committee--1989 Graduate Admissions Committee--Devel. and Cell Biology - September 1988 - May 1989. Neurosciences Task Force Committee--CCM - September 1988 - March 1989 Animal Research Committee, January l988 - March 1989 Seminar Coordinator, Developmental Biology Center, January - June, l988 and September,

1989 - 1990, Winter 1992, 1993, 1994 Graduate Cabinet, Fall l986 - 1987 Chair, Graduate Admissions Committee, Developmental and Cell Biology, Fall l986 -l987 President's Fellowship Advisory Committee, Spring l986 - 1990 Admissions Committee, Developmental and Cell Biology, l986 President's Fellowship Program Review Committee, Winter, l986 Seminar Coordinator, Developmental Biology Center, Fall 1985 Search Committee for Chairperson of Department of Anatomy, 1982-1983

MEMBERSHIP IN SCIENTIFIC SOCIETIES

Society for Developmental Biology—West Coast Representative 2004-2008, President-2009 International Society for Developmental Biology—Secretary 2010-2013 International Society for Differentiation—President 2012-2014 American Society for Cell Biology--Member of Council, 1994-1997 Member: Society for Neuroscience, American Association for the Advancement of Science

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CONFERENCE ORGANIZATION 2006-2012 Board of Directors, Gordon Research Conferences 2013- Conference Evaluation Committee, Gordon Research Conferences

2002 Organizer, Keystone Symposium on Spinal Cord/Neural Crest 2001 Co-Organizer, Developmental Biology Gordon Conference

1996 Co-organizer, Keystone Symposium on Vertebrate Development 1994 Organizer, Gordon Conference on Neural Development 1992 Co-organizer, Gordon Conference on Neural Development 1986 West Coast Regional Developmental Biology Conference