A cohort of children with myelomeningocele, born 2007- 2014:

Clinical characteristics Dahl M, Månsson E, Westbom L

Universities of Uppsala, Örebro and Lund, Sweden

Decreased incidence at birth

MYELOMENINGOCELE

Increased survival rate into adulthood

MMCUP Swedish National Quality Care Registry

Internet-based secondary prevention follow up

Spina Bifida and Hydrocephalus

AIMS OF THE STUDY

Children with MMC, born 2007-2014

1. Clinical characteristics?

2. Different from children with MMC,

born 1988 - 1991?

STUDY GROUP (23 children)

All children with MMC: * Born 2007-2014

* Uppsala/Örebro region

* Surgical closure

Medical records

MMC born 2007-2014 (n = 23)

Boys 13 (56 %)

Prematurity 5 (22 %)

Sectio 20 (87 %)

Asphyxia 5 (22 %)

Thoracal cele 9 (39 %)

MMC born 2007-2014 (n = 23)

Shunt 19 (83 %)

Severe spinal deform 10 (43 %)

Brainstem symptoms 8 (35 %)

Ad mortem < 1 mo 3 (13 %)

Ad mortem < 3 mo 4 (17 %)

MMC born 2007-2014: Socio-demographic characteristics

Mother first generation immigrant 17 (74 %)

Single parent 6 (17 %)

Prenatal diagnosis: 2007-2014

Early ultrasound 10

Late ultrasound 9

Not diagnosed 4

COMPARISON GROUP

All children with MMC:

* Born 1988 - 1991

* Uppsala/Örebro region

* Surgical closure

22 children (9 boys)

Children with MMC :

born 2007-2014 and 1988-1991

2007 1988 p

Mother immigrant 15/20 1/22 ***

Prenatal diagnosis 16/20 1/22 **

Early shunt 6/20 3/22 *

Ad mortem first mo 3/20 0/22

CONCLUSIONS

Newborn children with MMC today: 1. Mother often first-generation immigrant!

2. Most often prenatally diagnosed!

3. Often severe medical complications!