this issue Summit Presentation Schedule—AM P.1 Summit Presentation Schedule—PM P.2

Research Summit Keynote Speaker P.2 Physician Recruitment—Genesis IRB P.3

Physician Publication P.3 New Studies and Research Highlights P.4

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March/April 2015

Who we are…

Genesis Health System Office of Research and Grants Administration is here to help you. If you need assistance please contact us.

Sarah Castro Research Support Liaison (563) 421-7957 castros@genesishealth.com

Joy Lemmon Research Program Coordinator (563) 421-7956 lemmonjoy@genesishealth.com

Genesis Health System Research Promotion Fund To make a request to use the monies in the Research Promotion Fund, go to www.genesishealth.com/research and fill out the online application. You can also contact the Office of Research and Grants Administration for a copy of the application.

Once the Research Promotion Fund Committee receives a completed form, the committee does it's best to respond to applications within one week.

If you have questions about the Genesis Health System Research Promotion Fund, please direct them to Sarah Castro at CastroS@genesishealth.com.

Genesis Research Inquirer

GENESIS RESEARCH SUMMIT MORNING PRESENTATION SCHEDULE

Genesis Heart Institute—Adler Education Center Auditorium

Time Speaker Topic

7:30—8:30 am Keynote Speaker: Virend Somers, MD

Sleep Apnea and Cardiovascular Disease—Current Research and Clinical Implications

8:30—8:45 am Break

8:45—9:00 am Sarah Castro, MPH Research Program Update

9:00—9:20 am Jon Lemke, PhD Sleep Apnea Registry

9:20—9:40 am Tosha Allen, DNP, RN, CEN Jon Lemke, PhD

Rapid Response Calls and Code Blue Activations Relative to Sleep Apnea Status

9:40—10:00 am Jon Lemke, PhD Desyree Weakley, RN Alyssa Barkalow

Adherent Sleep Apnea Patients - What is the effect of diagnosis and adherence level on inpatient outcomes?

10:00—10:20 am Andy Gisleson, DO Regan Keeney, DO

The Prevalence and Cost of Unindicated Pre-Operative Diagnostic Testing for Elective Shoulder, Knee and Hip Surgeries

10:20—10:30 am Break

10:30—10:50 am Matt Arnold, PharmD MEDication Focused Outpatient Care for Underutilization of Secondary Prevention (MED-FOCUS)

10:50—11:10 am Nicolas Shammas, MD Cardiology Research—Forecast for the Future

11:10—11:30 am George Kovach, MD Adaptive Oncology Clinical Trial Design

11:30—11:50 am Eric Dippel, MD (invited)

Study of the Bard Lifestream Balloon Expandable Vascular Covered Stent in the Treatment of Iliac Artery Occlusive Disease (BOLSTER)

11:50 am—12:10 pm Conway Chin, DO (invited)

Study to Evaluate the Efficacy, Safety and Pharmacokinetics of SUN13837 Injection in Adult Subjects with Acute Spinal Cord Injury.

12:10—1:00 pm Lunch (on own)

AFTERNOON PRESENTATION SCHEDULE ON PAGE 2

JUNE 18 JUNE 18

Genesis Research Inquirer March/April 2015

GENESIS RESEARCH SUMMIT AFTERNOON PRESENTATION SCHEDULE

All Genesis employees and community partners are welcome to join for all or part of the day.

The Genesis Research Summit is a FREE event.

For More Information Call 421-7955

Genesis would like to acknowledge ResMed for providing support for this program.

Nationally Recognized Cardiologist is Keynote Speaker at 2015 Genesis Research Summit

Genesis is honored to present Dr. Virend Somers as the keynote speaker for this year’s Research Summit on June 18. Dr. Somers is a Professor of Medicine at Mayo Clinic and the Director of the Clinical Research Unit Sleep Core Laboratory and Cardiovascular Core Laboratory. Dr. Somers will be offering two keynote addresses at the Genesis Research Summit.

7:30—8:30 am— Sleep Apnea and Cardiovascular Disease - Current Research and Clinical Implications 1:00—2:00 pm— The Relationship Between Sleep Deprivation, Risk of Obesity and Cardio Metabolic Disease Dr. Somer’s research interests include neural and vascular mechanisms in circulatory control in health and disease. His research focuses on the role of the autonomic nervous system in cardiovascular regulation in humans, with an emphasis on normal and disordered sleep. He is also involved in studies of vascular biology in humans, examining how changes in neural mechanisms may influence the local control of blood vessels.

YOU DON’T WANT TO MISS THIS PRESENTATION!

Time Speaker Topic

1:00—2:00 pm Keynote Speaker: Virend Somers, MD

The Relationship Between Sleep Deprivation, Risk of Obesity and Cardiometabolic Disease

2:00—2:10 pm Break

2:10—2:30 pm Joyce Barnes, RN Nancy Ritter, RN Lynn Colberg, RN

Diffusing Essential Oils and the Effect on Stress Levels

2:30—2:50 pm Tina Bacorn, RN Non-Emergent Use of Emergency Departments

2:50—3:10 pm Ryan Kelly Assessment of Time to Hospital Re-Admissions and Number of Hospital Patient Days After an Initial Hospitalization for Heart Failure

3:10—3:30 pm Cherie Blackwell, OTR/L Sue Clemens, ORR/L, CBIS Kristen Mandle, OTR/L

Dynavision Normative Data for Reaction Time

3:30—3:50 pm Katherine Trujillo, PhD The Impact of Therapy Dogs on Family Members of Hospital Patients

3:50—4:00 pm Wrap-Up

Genesis Research Inquirer March/April 2015

Would You Like to Serve on the Genesis Institutional Review Board? Opportunities Available for Physicians The Genesis Health System Institutional Review Board (IRB) is looking for physicians with an interest in research and ethics! Member Responsibilities

1. Attend IRB meetings twice a month (2nd and last Tuesday) in-person or by phone 2. Review IRB application materials prior to each meeting and be ready to discuss issues related to human

subjects protection 3. Keep abreast of regulations and policies governing IRB review and the conduct of human subjects research

(training and continuing education provided)

INTERESTED? Call or e-mail Sarah Castro at 421-7957 or castros@genesishealth.com

Physician Research Accepted for Publication

Results from Dr. Nicolas Shammas’ study entitled, “In-hospital Outcomes of Patients Over 90 Years of Age Admitted for an Acute Coronary Syndrome at a Tertiary Medical Center” was recently accepted for publication in the Journal of the American Geriatrics Society. This high-impact journal is considered one of the top journals in Geriatrics. Dr. Shammas’ study compared major adverse events, including cardiac mortality, total mortality, stroke, major bleeding and acute renal failure between two cohorts of patients over 90 years of age that underwent percutaneous coronary intervention versus those treated medically for acute coronary syndrome. This study was supported by Genesis Research Promotion Funds.

Congratulations to Dr. Shammas on this impactful publication!

Summary of Genesis Health System IRB Activity March—April, 2015

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March 10, 2015 0 0 4 9 0 6 4 1 4

March 31, 2015 1 1 0 4 0 0 3 3 0

April 28, 2015 3 2 2 8 1 3 2 4 3

Total 4 3 6 21 1 9 9 8 7

% Expedited

Year-To-Date Total 6 10 22 40 3 21 18 24 28

% Expedited Year-To-Date 88%

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65% 57%

78% 47%

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90%

IRB Approved New Projects: March—April, 2015 4 New Studies Approved

Psychological Changes in Cancer Patients Participating in a Biobehavioral Intervention Principal Investigator: Melissa Wright, LMSW, OSW-C Rationale and Purpose: To determine how effective the “From Cancer to Health” treatment program developed by Ohio State University is in a larger, more diverse population of cancer patients. AdherentSleep Apnea Patients—What is the Effect of Diagnosis and Adherence Level on Inpatient Outcomes? Principal Investigator: Jon Lemke, PhD Rationale and Purpose: The purpose of this study is to categorize sleep apnea patients based on their reason for sleep study referral and their level of adherence, and examine whether this categorization has an effect on key health outcomes. Rapid Response Calls and Code Blue Activations Relative to Sleep Apnea Status Principal Investigator: Tosha Allen, DNP Rationale and Purpose: The purpose of this quantitative research is to (a) examine the relationship between rates of rapid response, code blues and sleep apnea status and (b) analyze the accuracy of nursing and physician documentation in regards to sleep apnea on patients who had a rapid response or code blue activation in the hospital. RN Satisfaction, Engagement, and Professional Development Pre and Post Implementation of a Re-Desgined Clinical Ladder Program Principal Investigator: Tosha Allen, DNP Rationale and Purpose: The purpose of this quantitative research is to utilize a Clinical Ladder Assessment Survey (CLAT) to (a) assess the current program and the newly designed program and (b) to compare pre- and post-implementation data.

Research Highlights—Nine Studies were Completed in March—April, 2015

E1305 A Phase III Randomized Trial of Chemotherapy with or without Bevacizumab In Patients with Recurrent Or Metastatic Head and Neck Cancer Principal Investigator: Shobha Chitneni, MD Use of Avanta SR MCP Metacarpophalangeal Finger Joint Implant AND Use of Avanta SR PIP Proximal Interphalangeal Finger Joint Implant Principal Investigator: Thomas VonGillern, MD Experience and Outcomes with Treatment of Coronary Chronic Total Occlusions at a Tertiary Medical Center: A Retrospective Analysis Principal Investigator: Nicolas Shammas, MD In-Hospital Outcome of Nonagenerians Admitted for an Acute Coronary Syndrome at a Tertiary Medical Center Principal Investigator: Nicolas Shammas, MD APEX Trial-Multicenter, Randomized, Active-Controlled Efficacy and Safety Study Comparing Extended Duration Betrixaban with Standard of Care Enoxaparin for the Prevention of Venous Thromboembolism in Acute Medically Ill Patients Principal Investigator: Nicolas Shammas, MD

A Multicenter, Randonmized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy, Safety and Pharmacokinetics of SUN13837 Injection in Adult Subjects with Acute Spinal Cord Injury Principal Investigator: Conway Chin, DO SWOG S1201: A Randomized Phase II Pilot Study Prospectively Evaulating Treatment for Patients Based on ERCC1 (Excision Repair Cross-Complementing 1) for Advanced/Metastatic Esophageal, Gastric or Gastroesophageal Junction (GEJ) Cancer Principal Investigator: George Kovach, MD

Implementation of a Treatment Based Classification System for Neck Pain. Principal Investigator: Chris Hunter, MPT, OCS

Genesis Research Inquirer March/April 2015