Economic Development Advisory Group

March

2012Meeting

2

Agenda

I. New Member Introduction – Bryan Jamele, MLSC

II. BioLeads Update

III. MLSC Tax Incentives Award

IV. MassBio Annual Meeting Preview

- MassBio Leading Edge Award- BioMFG Panel

V. BIO 2012 Preview

VI. MFG Survey update - Don Walsh

VII. Review of Governor's "Choosing to Compete in the 21st Century" plan

I. New Member Introduction

Bryan Jamele (Ja-Mel-y)

Governmental Relations and Policy Manager,

Massachusetts Life Sciences Center

3

4

II. BioLeads Review

The BioLeads team (MassBio, MLSC, MOBD, MOITI, MassEcon) oversaw 94 qualified company leads in 2011 through November.  Of these leads, 21 became "wins", with companies located to or expanding in Massachusetts, 9 were "positive resolutions", with companies resolving issues with limited or no team assistance, and 14 leads were "tabled", with leads ending or not being positively resolved.  Currently, there are 43 active leads.

Several wins include foreign companies that opened operations in Massachusetts.  The wins in 2011 have included:

Avaxia, Acebright (China), AB Biotherapautics (Spain), Curementa, Diagnostics for All, HighRes Biosolutions, Pharyx, En Vivo, IDBS (UK), T2 Biosystems, Screen Cell, Prism Ideas (UK), Radisens Diagnostics (Ireland), Variation Technologies (Canada), DPS Biometrics, Vertex, Early Sense (Israel), Ipsen Biomeasure, Sony DADC (Japan), and Izon (New Zealand).

Collectively, these companies plan 408 net new jobs in Massachusetts by the close of 2012.

The team considers wins those leads that are positively resolved in which one or more team members took an active roll.

III. LSI Tax Incentives

5

http://www.masslifesciences.com/index.html

$21.2 million to 28 companies

$24,486 per job created

Types of BenefitsRefundable 10% Investment Tax CreditRefundable Research Tax CreditJob Creation Tax Credit – New!Special Sales Tax ExemptionExtension of Let Operating Losses to 15 yearsRefundable FDA User fee CreditLife Sciences Research CreditDeduction for Orphan Drug Clinical TestingElimination of Sales Factor ThrowbackConstruction Sales Tax Exemption

6

The goals of the Annual Meeting are to Connect, Collaborate, and Innovate:

1. Discuss and debate the most relevant science  and business topics driving industry’s innovation challenges

2. Promote collaboration with industry scientists, CSOs and other life sciences leaders to enhance scientific and business understanding, augment deal flow and connections.

3. Forge new scientific and business relationships

4. Build the network of up-and-coming academic scientists

IV. MassBio Annual Meeting

http://www.massbio.org/events/calendar/1342-massbio_annual_meeting/event_detail

Monday, March 26 – Tuesday, March 27 at Sonesta Cambridge

IV. Annual Meeting: Leading Edge Award

7

Leading Edge Award Presentation - Monday, March 26th at 3:20 PM

Summary of Award Scoring

Pfizer Center for Therapeutic Innovation (CTI) 3 WinnerAlexandria Real Estate Equities 4Massachusetts Biomedical Initiatives 4Shire HGT 5Cummings Properties 6Ginkgo Bioworks 6Venture Development Center – UMass-Boston 6Addgene 7

HonorableMentions

• significant contributions made to further Massachusetts as a life sciences hub.• Innovators/innovations helped advance biotech and life sciences in these areas.• improved the competitiveness of Massachusetts as a destination for the life

sciences .

8

IV. Annual Meeting: BioMFG Panel

What will biomanufacturing look like in 2025?

Turns out that New England is a global leader in biomanufacturing. The panel will focus on the key differentiators that set biomanufacturing here apart and discuss what the sector will look like in the next decade. As the industry shifts to different kinds of products, such as combination products, cell therapies and nanomaterials. History with the molecule will be more important than ever in delivering quality, compliant, and successful products. More than ever, having manufacturing assets proximate to core research will affect success at the drug development transition point and beyond.

Moderator: Mickey Koplove

Panelists:•Michael Cicio, VP Operations and Site Manager, New England Operations, Lonza Biologics•Scott Lauder, Senior Director and Global Head, Protein and Cell Sciences, EMD Serono•Carl W. Lawton, Director, Massachusetts Biomanufacturing Center, UMass Lowel•Ralph Lambalot, Vice President, Biologics Development & Manufacturing Launch, Abbott

9

V. BIO 2012 - Pre-Bio Activities

Friday, June 15, MassBio will host networking sessions, an orientation lunch, and industry cluster tours. Morning networking will include discussions featuring panelists from local industry and the academic and hospital-based research communities. After lunch, attendees will be provided tours of the area’s biotechnology supercluster. The day will conclude with a reception at Tech Square in Cambridge.

Sunday, June 17, Massachusetts Global Gateway Welcome Reception at the New England Aquarium in Boston. The event will feature national “meet-up” stations, facilitating networking in an informal setting. International sponsors will also be featured as speakers during “national toasts” which will occur throughout the event. This event, hosted by MassBio and MOITI, will provide attendees an opportunity to make helpful connections in a relaxed and fun atmosphere before the business of the BIO International Convention begins.

Tour I: Broad Institute, Biogen IdecTour II: Millennium, VertexTour III: Genzyme, Center for Life Sciences, Pfizer CTI

New England Aquarium

V. BIO 2012: Massachusetts Pavilion

Booth 137: 7,700 square feet at front of convention hall

V. BIO 2012: Massachusetts Pavilion Branding

Pavilion brand and logo

MA is a leader in all stages of the life science lifecycle Ideas – People, Academia & Hospitals

Early Stage – Start Ups, Entrepreneurial culture

Drug Development, supportive eco-system

Manufacturing

Collaboration – government, non-profits, industry

Pavilion Floor Plan

There are 5 storyboard panels in

the Pavilion.

Each one of these panels is double-

sided.

A patient’s photo will be featured on the

front of each storyboard, along with text that will tell their

story and that will highlight their

connection to the state.

On the reverse side of each patient story, we will highlight the role that MA companies

play in the life science “lifecycle”.

Patient Story Boards

*Mock-up/draft version of patient story, for viewing purposes only. Currently in draft by 451 Marketing

Some sponsors will be featured on either side with

logo and text.

Patient photo will be wrapped in graphic

“DNA Strand” that will highlight connections

this patient has to MA: for example,

what company manufactures the therapy that has treated his/her disease; the

hospital/center where he/she has been

treated; and who was responsible for the

research and development of the

drug.

Other connections may be highlighted.

Pavilion Floor Plan

.

On both sides of our 10’ x 20’ LED screen

we will highlight aspects of our cluster

that make us THE Premier place in the

world for biotechnology:

-Cities and towns that support the cluster

-Workforce developmentinformation

-Statistics highlighting MA strengths such as: NIH-funding to both hospitals

and academic institutions; VC funding; employment

numbers; drugs in the pipeline.

-Timeline of the industry in MA.

Left Side of the Tall Wall in Pavilion

Timeline

Workforce DevelopmentStatistics

*Mock-up/draft version of patient story, for viewing purposes only.

Currently in draft by 451 Marketing

Right Side of the Tall Wall in Pavilion

Cities and Towns

Timeline Part 2

*Mock-up/draft version of patient story, for viewing purposes only.

Currently in draft by 451 Marketing

Conference Rooms

Conference Rooms will be available for

use by Pavilion Sponsors and

Partners to hold their partnering meetings.Meeting spaces are

located behind the tall walls in the Pavilion.

18

VI. Manufacturing Survey

Don Walsh

19

VII. Choosing to Compete in the 21st Century

Released by Governor Patrick in December

5 Steps Toward a More Competitive Economy

1. Advance programs for “Middle-Skill” jobs2. Support Innovation and Entrepreneurship3. Regional Development Focus4. Increase Ease of Doing Business5. Address Cost Competitiveness

Compete - continued

20

1. Advance programs for “Middle-Skill” jobs- Clarify leadership for workforce training- “Stackable Opportunities” e.g. internships, apprenticeships- Evaluation and accountability of system- Support success like Workforce Training Fund- Regional focus- Increase range of population receiving training- Best practice STEM programs, emphasize hands-on

programs

2. Innovation & Entrepreneurship- Identify 3-5 areas of global innovation excellence- Increase 20% funding of mentoring, incubator, and

accelerator programs- Increase internships by 20%- Incentivize Gateway Cities - Raise profile of advanced MFG- Systemic effort to locate ancillary activities of companies in

state

21

3. Regional Development Focus- Identify priority development areas- Target state investments at such areas- Create regional CEO for Development teams- 10% of communities develop strategies- Establish regional best practice academies

4. Increase Ease of Doing Business- Ongoing state regulatory review - Establish regulatory ombudsman- Business advisory group on regulations- Continue to consolidate economic development agencies- Make regional organizations true partners- Increase state Ambassadors programs- Increase host activities- Showcase development ready sites

Compete - continued

22

Compete - continued

5. Cost Competitiveness- Move away fro fee-for-service health care to global

payments- Enhance consumer choice in health care- Use e-health technologies to lower costs- Diversify energy portfolio- Pursue renewables for generation to grid- Review of UI system- Simplify tax structure- Shift to non-tax business incentives (training, infrastructure,

financing) to support development- Establish accountability for tax-based incentives

23

VIII. 2012 EDAG Scehdule

•Wed. June 6th at MassBio•Wed. September 12 at MassBio•Wed. Dec. 5th at MassBio