management of prevalent infections in children following a disaster · 2018-10-01 · the imci...
TRANSCRIPT
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MODULE V
Management of Prevalent Infections in Children Following a Disaster
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• Acute respiratory infections
• Diarrhea and dehydration
• Measles
• Malaria
• Malnutrition
MAIN CAUSES OF DEATH
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Leading Causes of Death (under age 5)
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Prevalent Infections in Children
• Morbidity and mortality resulting from an acute humanitarian emergency in developing countries are related to the excessive childhood mortality that existed prior to the disaster.
• Conditions are made worse during the disaster (crowding, compromised hygiene, contaminated water, poor sanitation), increasing mortality from common childhood infections.
• Pre-existing health conditions, nutritional status, and immunization rates are important to know!
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Integrated Management of Childhood Illness (IMCI)
• Designed by WHO and UNICEF in 1990s• Strategy to reduce morbidity and mortality from the most
prevalent diseases in developing countries based on simple clinical signs and procedural algorithms
• Early diagnosis Early treatment Timely referral• Community-based approach• Improves parenting skills and practices associated with
home care• Integrates aspects of nutrition, immunization, health
promotion, and disease prevention
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The IMCI strategy
2 components based on the child’s age:(1) Sick young infant aged up to 2 months (2) Sick child aged 2 months up to 5 years
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The IMCI strategy
• The clinical decision making approach involves using a limited number of symptoms and signs to classify the severity of illness, which determines the management with guidelines for follow-up, counseling for the parents, and instructions regarding when to return and if additional care is needed.
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IMCI Management: Assessment
• All sick children are assessed for “general danger signs”– Seizures, unconsciousness/lethargy, inability to drink or
breastfeed, persistent vomiting– Indication for immediate referral or admission to a hospital
• All sick children are routinely assessed for: – Major symptoms1 week – 2 months: bacterial infection and diarrhea2 months – 5 years: cough or difficulty breathing,
diarrhea, fever, ear problems– Nutritional and immunization status– Feeding and other potential problems
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IMCI Management: Classification
• Uses a few carefully-selected clinical signs – Based on their sensitivity and specificity to detect
disease• A combination of individual signs leads to a
child’s classification rather than a diagnosis– Classifications are color coded– Red/Pink = urgently refer to a higher level of care – Yellow = requires specific treatment– Green = can be safely managed at home
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IMCI Management: Treatment and Counseling
• Guidelines address most illnesses (but certain chronic or less common illnesses may require special care)
• Management procedures – Uses a limited number of essential drugs– Encourages active participation of caretakers
• An essential component of the IMCI guidelines is the counseling of caretakers (feeding, fluids, return precautions)
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IMCI Case Management at First Level, Referral Level and at Home
FIRST-LEVEL OUTPATIENT HEALTH FACILITY
Give FOLLOW-UP care when the child returns, and if necessary, reassess for new problems
Ask about CHILD’S PROBLEMSCheck for
GENERAL DANGER SIGNS
ASSESS for MAIN SYMPTOMS:COUGH OR DIFFICULT
BREATHINGDIARRHOEA
FEVER
ASSESS forMALNUTRITION AND ANAEMIA
Check for OTHER PROBLEMS
CLASSIFY CHLID’S
CONDITIONSAND
IDENTIFYTREATMENT
“YELLOW” -SPECIFIC
TREATMENT AT FIRST
LEVEL FACILITY
“GREEN” -HOME
MANAGEMENT
“RED” - PRE-REFERRAL
TREATMENT AND
REFERRAL
ADVISEparents about
REFERRAL
FIRST-LEVEL REFERRAL HEALTH FACILITY
EMERGENCY TRIAGE
ASSESSMENT AND
TREATMENT(ETAT)
DIAGNOSE AND TREAT COMMON SERIOUS
CONDITIONS
MONITOR PATIENT PROGRESS
TEACHparents about
treatment
COUNSELthem about
feeding and when
toreturn
HOME
GIVE ORAL DRUGSAND/OR
TREAT LOCAL INFECTION
GIVE FOOD AND FLUIDS(follow feeding recommendations)
RETURN TO HEALTH FACILITYWHEN NEDED
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Essential IMCI drugs
• ORT• Sugar water• Paracetamol• Mebendazole• Salbutamol• Iron• Vitamin A• Gentian Violet• Diazepam
• Oral antibiotics– Amoxicillin & bactrim– Ciprofloxacin– Tetracylcine & erythromycin
• Oral antimalarials• Tetracycline eye ointment
• IM Quinine• IM Ampicillin• IM Gentamicin
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Sick young infant aged up to 2 months
• Classification and management Severe disease (pneumonia, meningitis, and sepsis) Local bacterial infection Jaundice Diarrhea HIV infection Poor weight gain Breast feeding and other feeding problems Immunization status Mother’s health
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Severe disease (RED/PINK)
• Not feeding, convulsions, fast breathing (more than 60 breaths per minute), severe chest in-drawing, fever or low temperature, and lack of movement
• Refer urgently to the hospital with a first antibiotic dose and treatment to prevent low blood sugar
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Local bacterial infection (YELLOW)
• Signs of umbilical infection (redness and or purulent discharge) or skin pustules
• Treat with an appropriate antibiotic
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Sick child aged 2 months up to 5 years
• Classification and management Respiratory disease Diarrhea Febrile illness (malaria) Measles Ear infections Malnutrition Anemia HIV Immunization status
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IMCI Strategy: Danger Signs
• Unable to drink or breast feed • Vomits everything• Had convulsions• Lethargic or unconscious• Convulsing now
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Very severe respiratory disease• Any general danger sign• Stridor in a calm child
Pneumonia• Fast breathing• Chest indrawing
Cough without pneumonia• No signs of pneumonia or severe disease
IMCI: Cough or Difficulty Breathing
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INFLUENZA VIRUS
• Family Orthomyxoviridae– “myxo” mucus– segmented, single-stranded
RNA
• Influenza A first isolated 1933; Influenza B 1940
• 15 hemagglutinin (HA) and 9 neuraminidase (NA) subtypes– Only H1N1, H2N2, H3N2
subtypes associated with widespread epidemics in humans
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Clinically Relevant Influenza Viruses
Type A Potentially severe illnessEpidemics and pandemicsRapidly changingBirds, swine, horses, seals, humans
Type B Usually less severe illnessEpidemicsMore uniformHumans
Type C Usually mild or asymptomatic illness Minimal public health impactHumans, swine
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Influenza: A Continually Changing Virus
Polymerase Proteins (PP)
Hemagglutinin (HA) *cell entry
Neuraminidase (NA)*cell escape
M1, M2
Nucleoprotein (NP)
Adapted from: Hayden FG et al. Clin Virol. 1997:911-942.
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RNA
Hemagglutinin
NeuraminidaseAntibodiesSialic acid
Antigenic Drift (A & B)
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Antigenic Shift (A only)
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Transmission of Influenza
• Person to person• Droplet spread
– small particle aerosols• Fomite contamination
– Steel and plastic 24-48 hrs– Cloth, paper, tissues 8-12 hrs– Hands 5 min (high viral titer)
• Principal site of replication- columnar epithelium• Incubation period- 18 hrs to 5 or more days (average 2-3 days)• Virus shedding 3-7 days• Viral titers are generally higher in young children with shedding
lasting 10 days or longer
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Recognizing Pediatric Influenza
Neonates Infants/Toddlers Children/Teens
High fever GI symptoms Rapid onsetLethargy Fever >103°F (>39.5°C) High feverDecreased eating Anorexia CoughMottling Respiratory syndromes ChillsApnea Malaise
HeadacheSore throat
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Influenza Virus Complications
• Acute otitis media (children)
• Sinusitis• Pneumonia• Exacerbation of
underlying illness• Dehydration (infants)
• Encephalopathy• Reye syndrome
(children)• Myositis• Myocarditis• Febrile seizures
Common Complications Uncommon Complications
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MEASLES
• Highly contagious infection (98-100% in susceptible contacts)
• Transmission through respiratory secretions(contact and aerosolized particles)
• Incubation period: 10-14 days
• Mortality rate ⇒ Nutrition / crowding / inoculum
Overcrowded living conditions are an important triggering factor for epidemics
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Natural History of Measles
Identification of one case in a camp should speed up immunization process
Day 1 Day 2 Day 3 Day 4 Day 5 Day 6 Day 7Incubation 10-14 days
Fever ------------- FEVER--------------------]Cough ---------------------------------------------------- - - -Conjunctivitis ----------------------------------------- - - -Coryza ------------------------------------------------- - - -
Köplik spots---]
Exposure
Rash ---------------- - - -
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Measles Rash – DAY 1
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Measles Rash – DAY 2
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Measles Clinical Manifestations
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Measles and Vitamin A Deficiency
MEASLES unmasks an underlying Vitamin A deficiency
SYNERGIC EFFECT
VITAMIN A DEFICIENCY (even subclinical) increases measles-associated morbidity and mortality
Measles-associated morbidity and mortality may be reduced by administering Vitamin A to high risk
populations
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Measles Management
• Evaluate for associated infections • Classify any child having a general danger
sign, clouding of the cornea, or deep or extensive mouth ulcers as severe complicated measles and refer urgently to the hospital with vitamin A, the first dose of an appropriate antibiotic, and if there is eye discharge or corneal clouding a dose of tetracycline eye ointment.
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Measles Management
• The presence of eye drainage and or mouth ulcers without other signs is classified as yellow. Treatment includes Vitamin A, tetracycline eye ointment for eye discharge, and gentian violet for mouth ulcers. These children need a follow up visit in 3 days.
• A child without complications is green and needs only vitamin A.
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Algorithm for a Suspected Case of Measles
Child with fever and rash consistent
with measles
Report case toAlert System
Search for othercases andQuarantine
Start response and
prevention
Measles vaccinePriority groups
Resources and logistics
Case Confirmation• Laboratory tests
Local response• Guarantee vaccines• Vitamin A• National Response
Team
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Incubation
HeadacheMyalgiaRashBone painVomiting
Abdominal PainCyanosisShockHemorrhagesHepatitisPlasma leakage
DENGUE
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Clinical Manifestations of Dengue
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Grade Hemorrhage Platelets CapillaryPermeability
I Positive <100,000 Plasma leakage*tourniquet test
II Spontaneous <100,000 Plasma leakage*bleeding
III (DSS) Spontaneous <100,000 Plasma leakage+bleeding PP <20 mmHg
Hypotension
IV (DSS) Spontaneous <100,000 Profound shockbleeding Absent pulse or BP
*Hct admission >20%/age or reduction Hct >20% post-resuscitation fluidsPP: pulse pressure
WHO Guidelines for the Diagnosis of Dengue Hemorrhagic Fever (DHF)
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• 80% asymptomatic infections
• Unusual manifestations– Hepatitis– Encephalopathy– Pancreatitis – Pleural effusion
Dengue Manifestations in Children
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• Rest
• Acetaminophen/Paracetamol
• No aspirin or NSAIDs
• No antibiotics
• Oral rehydration (WHO solution)50 mL/kg over 4-6 hoursMaintenance 80-100 mL/kg/day
• Monitor CNS signs
Management of the Child with Dengue
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• Hospitalization in case of grade II HDFPlatelets <100,000 Hematocrit > 20% over normal
• Colloid solutions at 6 mL/kg/hr
Management of the Child with Hemorrhagic Dengue
Improvement Worsening
↓ 3 mL/kg/hr ↑ 10 mL/kg/hr
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MALARIA
Caused by a protozoal blood parasite capable of causing a wide spectrum of diseases
Plasmodium vivaxPlasmodium ovalePlasmodium malariae
• Geographical distribution: Tropic / Subtropics
• Transmission: Anopheles mosquito
Plasmodium falciparum
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Malaria Susceptibility
In endemic areas, there is partial immunity in older children and adults due to previous infection
Most susceptible individuals to severe and fatal malaria: • Non-immune and immunocompromised people • Infants and young children, pregnant women and
malnourished •Plasmodium falciparum-infected people
InfectionIdentification of parasitemia
Asymptomatic
DiseasePresence of signs and
symptomsAcute, subacute, chronic
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FEVER
37
38
39
Non-specific Pattern
393837
Classical Pattern
Partially immune patients may develop moderate fever with a non-specific pattern
Patients will feel and look sick due to fever, but they will feel relatively well between paroxysms of fever
Associated chills, headache, myalgia
Malaria Clinical Manifestations
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Severe Malaria
• Parasitemia is >5%• Any of the following complications:
-prostration (patient unable to sit or walk)-multiple convulsions-impaired consciousness not attributable
to another cause-abnormal bleeding-meningeal signs-jaundice ( hemolysis)
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Malaria Diagnosis
• Rapid diagnostic tests– Bedside testing
• Thick and thin blood smears– Difficult in a disaster situation
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Malaria Management
• The clinical diagnosis of malaria based on non specific signs and symptoms tends to be highly inaccurate.
• When a patient presents with febrile illness who lives in an area with malaria, in the absence of available diagnostic testing, begin treatment when the clinical history and presentation are consistent with malaria.
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Types of Malaria
P. falciparum – Most severe type of MALARIA (MALIGNANT)High lethality rate in infected individualsHighly drug-resistant
Plasmodium vivax “BENIGN” MALARIAPlasmodium ovale Most are sensitive Plasmodium malariae to chloroquine
• These infections cause morbidity and contribute to multifactorial mortality
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Treatment of Uncomplicated Malaria: P. Falciparum or Unknown Species
Preferred Therapies (check your country policy):
Atovaquone-Proguanil (Malarone)– 4 adult tabs (1000mg Atovaquone) po qd x 3 days
Artemether-lumefantrine (Coartem)– 4 tablets immediately, 4 tablets 8 hours later, then
4 tablets BID for 4 more doses
Second-Line Therapies: Quinine sulfate plus: Doxycycline, Tetracycline, or Clindamycin
Mefloquine
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Uncomplicated Malaria: Chloroquine-Sensitive Species/Areas
• Children: a total dose of 25 mg/kg of CHLOROQUINE over a 3-day period
t = 0 10 mg/kg pot = 6 h 5 mg/kg po or 10mg/kgt = 24 h 5 mg/kg po at t = 24 ht = 48 h 5 mg/kg po
• Adults: similar schedule. 1 gr followed by 500 mg x 3
• Pregnant women: Malaria is SEVERE. Chloroquine treatment is safe
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Malaria Supportive Treatment
• Fever control– Antipyretics, no more than a few doses– Cool compresses
• Dehydration– Oral rehydration solution, increased need for fluids
• Malnutrition– Assess and treat
Anticipate symptom resolution at 48-72 hours
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Severe Complicated Malaria Treatment
• First line (preferred treatment) is Artesunate parentral (IV/IM).
• In the absence of parenteral form of Artesunate, Artemether IM is acceptable.
• Quinine is acceptable option but requires attention to the proper dosage and administration with IV fluids. There is a loading dose and maintenance dose and care needs to be taken to prevent hypoglycemia.
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Summary
• Pre-existing health conditions, nutritional status, and immunization rates are important to know!
• IMCI is a strategy developed by WHO to reduce morbidity and mortality from the most prevalent diseases in developing countries based on simple clinical signs and procedural algorithms
• IMCI focuses on a community-based approach to promote home care and timely referrals and integrates aspects of nutrition, immunization, health promotion, and disease prevention
• Examples: Influenza, Measles, Dengue, Malaria
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Thank you