Average Wound Area800.0

700.0

600.0

500.0

400.0

300.0

200.0

100.0

0.0

-100.0Days Post Injury

4 7 10

Wo

un

d A

rea

(mm

2 )

NEOSALUS™

Johnson & Johnson Dressing

Biafine®*

* Biafine is a registered trademark of Ortho Dermatologics

Time Point (Days Post Injury)

Tota

l In

flam

mat

ion

Sco

re

Score is an aggregate of edema, erythema, exudate.

22

7

Signs of Inflammation*

* Biafine is a registered trademark of Ortho Dermatologics

1 4 10 14

20

18

16

14

12

10

8

6

4

2

0

NEOSALUS™

Johnson & Johnson Dressing

Biafine®*

Prevention of Sodium Lauryl Sulfate Irristant Contact Dermatitis by Proderm from Skin Protectant6

6

Days

N=20

5

4

3

2

1

0

0 1 2 3 4 5 6 7 8 9 10

Untreated Treated with Proderm

Mea

n Ir

rita

ncy

Sco

re

60%

50%

40%

30%

20%

10%

0

37%

10%

53%

Stopped Using or Reduced Corticosteroid

Use

Corticosteroid Use Compared to Baseline

No Change inCorticosteroid Use

IncreasedCorticosteroid Use

n=31

Efficacy of a Skin-Protective Foam in the Treatment of Chronic Hand Dermatitis

Per

cen

tag

e o

f S

ub

ject

s

Efficacy of NEOSALUS™ Foam in Subjects Diagnosed with Chronic Hand Dermatitis

5

Overall Improvement in Investigator Global Assessment Score

Baseline Finaln=40

4

3

2

1

0

Group A Group B

2.73 2.94

n=22 n=18

Weeks 1-2

1.82n=22

2.30

n=18

Weeks 3-8

NEOSALUS™ FOAM (TID) + Triamcinolone

Cream 0.1 % (TID)

P=0.1442; one sided t-test

Cetaphil®

Moisturizer(TID) + Triamcinolone

Cream 0.1 % (TID)

NEOSALUS™ FOAM (TID) + Triamcinolone

Cream 0.1 % (PRN)

Cetaphil®

Moisturizer(TID) + Triamcinolone

Cream 0.1 % (PRN)

P=0.0318; one sided t-test

Group AGroup B

Mea

n I

GA

Sco

re

50

Group A

Group B

9

30

n=20

n=15

Triamcinolone Cream 0.1 %

Triamcinolone Cream 0.1 %

P=0.0359; one sided t-test

40

30

20

10

0Mea

n T

ota

l o

f A

pp

lica

tio

ns

75Untreated

Day 0

Treated with Proderm Technology®

70

65

60

55

50

45Day 10 Day 21

n=24

Hyd

rati

on

Per

cen

tag

e