malignant lesions of the cervix
DESCRIPTION
Malignant lesions of the CERVIX. Dr . Saadeh Jaber OBGYN consultant 2010. Epidemiology. Cervical cancer is the 2 nd most common cancer in the women worldwide Rare before 20yrs ,,, mean age is 47yrs. Factors associated with high risk. Multiple sexual partners. Human papillomavirus(HPV). - PowerPoint PPT PresentationTRANSCRIPT
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Epidemiology
• Cervical cancer is the 2nd most common cancer in the women worldwide
• Rare before 20yrs ,,, mean age is 47yrs
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Factors associated with high risk
Multiple sexual partners
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Human papillomavirus(HPV)
Infection with HPV is one of the major factors leading to CC
Type 16 and 18
Type 6
and 11
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Pathophysiology
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Pathophysiology
The area between the original SCJ and
the new SCJ
Is called the transformation
zone(ectropion)
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Cervical Intraepithelial Metaplasia
3 grades --> depending on the degree of cytological atypia thickness of the epi involved
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Cervical Intraepithelial Metaplasia (CIN)
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Screening and Cytology
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Pap smear Conventional smear Liquid Based smear
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Colposcopy
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Treatment of CIN
Observation mild dysplasia (CIN I) may regress
spontaneously
Active treatment higher grades CIN II / CIN III
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Invasive CancerPathological features2 main types Squamous cell carcinoma --> most
cases Adenocarcinoma --> 15 – 20%
Most occur at the SCJ
Melanoma and sarcoma occur rarely
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Invasive CancerPatterns of spread
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Invasive CancerStaging
Cervical cancer is the only gynecological malignancy that is
not surgically staged
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