Organised by:

Malaysian Healthy Ageing Society

Co-Sponsored:

Muscle Health Promotion System

for Prevention of Muscle Function Decrease

Cheolmin Kim, M.D., PhD

Research Center for Anti-Aging Technology Development

Agenda

Introduction

About RCAATD

Device Development

Functional Food Development

4/49

Aging ? Anti-Aging?

Aging ? multidimensional process of physical, psychological, and social changes in a person over time

Anti-Aging ? slowing down or reversing the processes of aging to extend both the maximum and average lifespan

The target of Anti-Aging ? • slowing down the aging processes • keep healthy living during aging • So well aging

Exercise, Nutrition, Relation, Participation

• Anti-Aging in Technology (view of engineer) • Healthy Aging in Practice (view of clinician) • Active Aging in Society (view of sociologist)

• Well Aging for better life (view of people)

Even though there’s controversy still now. (cf. Anti-aging Medicine)

5

Different views give different image. However, The real characteristic is same. It’s a cup for drinking coffee conveniently, safely, and comfortably.

6/49

Walking is the best and simplest way of exercise

Exercise Activation of almost every body function

Energy control

Walking is best

GI function control

Energy control

BP control

Weight load

Heart attack ↓ Good posture

cognition ↑

GH & hormone balance

cognition ↓

No movement

DM ↓

Dementia↓

Back pain↓

Osteoporosis↓

Anti-aging↓

Dementia ↑

Every function↓

Skeletal muscle wasting in cachexia and sarcopenia

Diseases

Diseases

Cannot Work. Cannot Move.

Cannot Exercise In vicious circle

8/49

EXERCISE MIMETICS

If he/she cannot Walk by himself/herself ?

Nutrition ↑

→ Metabolism ↑

Circulation ↑

Self exercise → Recovery

Assisted exercise

→ M. function ↑

Functional Foods

Devices

Synergistic Effect

Walking is the best and simplest way of exercise

Age-related increase of inflammation in fat t.

Sarcopenia

Age-related Decrease of Muscle Function

Energy ↑ Metabolism ↑ M. cell ↑ Circulation ↑ Infl. ↓ Lipolysis↑

Functional Foods Devices

Local Effects Whole body Effects

Organization of R&D team in RCAATD

Functional Foods

Devices

Donga Univ.

Dongeu Univ.

Pusan Univ.

BTP SPIC

Sea-origin

Device develop Clinical test

Natural Hub

Evaluation model

System develop Standardisation

Integration of effective stimulation modules

Devices

Heat

Vibration

Electric

Light

Magnetic

BIA (Bio-electrical Impedance Analysis) module

1820

1840

1860

1880

1900

1920

1940

1960

1980

1 2 3 4 5

Series1

Series2

Series3

1600

1650

1700

1750

1800

1850

1900

1 2 3 4 5

Series1

Series2

Series3

Processes and Aim of Functional Foods Development

• Resources Library

• Objective evaluation and Clinical test

• Get permission of Functional Food from Korean FDA

• Global marketing

Functional Foods

Resources Library of Functional Foods

Functional Food Resources from Marin Origin

Objective evaluation of Function of Food materials

In vitro Cell Culture Model using C2C12 myoblasts C2C12 cells were originally obtained by Yaffe and Saxel (1977) through selective

serial passage of myoblasts cultured from the thigh muscle of C3H mice 70 h after a

crush injury.

These cells were shown to be capable of differentiation.

C2C12 cells are a useful model to study the differentiation of non-muscle cells to

skeletal muscle cells (e.g., myosin phosphorylation mechanisms) and express muscle

proteins and the androhen receptor (AR).

C2C12 cells can be used to study the differentiation of myoblast and osteoblast.