major histocompatibility complex...asw a.tl dba/i bio.s,sjl stoli,bi o.q, bdp *the r designates a...

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Major Histocompatibility Complex Chapter 8

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Page 1: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution

Major Histocompatibility Complex Chapter 8

Page 2: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution

I

TLA

Qa-1 Qa- 2

TL

TLA

Figure 8-1

Page 3: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution
Page 4: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution

MHC

• Haplotype: – The set of alleles present on each

chromosome – Outbred individuals have 2 haplotypes – Inbred individuals have 2 identical

haplotypes

• MHC molecules are co-dominantly expressed.

Page 5: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution

Inbred Mice

• In a given inbred strain of mice, every mouse is genetically identical to every other mouse in that strain. – Syngenic – Allogenic

• Strains or individuals express different alleles.

Page 6: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution
Page 7: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution
Page 8: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution
Page 9: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution

Graft Nomenclature • Isograft

– Graft from one individual to itself

• Syngenic – Graft between identical individuals

• Allograft – Graft between individuals of different strain.

• Xenograft – Graft between different species

Page 10: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution
Page 11: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution
Page 12: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution
Page 13: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution
Page 14: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution
Page 15: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution
Page 16: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution
Page 17: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution
Page 18: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution
Page 19: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution
Page 20: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution
Page 21: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution
Page 22: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution
Page 23: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution
Page 24: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution
Page 25: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution
Page 26: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution

Diversity • MHC molecules exhibit a high degree of

diversity • Diversity is due to polymorphism or the

presence of multiple alleles in the population for a given locus.

• The sequence variation between alleles is clustered to the α1/α2 and α1/β1 regions of class I and class II molecules respectively.

Page 27: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution
Page 28: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution
Page 29: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution
Page 30: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution
Page 31: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution
Page 32: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution
Page 33: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution
Page 34: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution

Ting and Trowsdale, 2002

Page 35: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution
Page 36: Major Histocompatibility Complex...ASW A.TL DBA/I BIO.S,SJL STOLI,BI o.Q, BDP *The R designates a recombinant haplotype, in this case between the H-2a and H-2b types. Gene contribution