mahesh swaminathan 1, b. tegbaru 2, b. wolff 3, n. kleinman 4, a. alem 5, w. alemu 6, r. shiraishi...
TRANSCRIPT
Mahesh Swaminathan1, B. Tegbaru2, B. Wolff3, N. Kleinman4, A. Alem5, W. Alemu6, R. Shiraishi1, P. Fonjungo3, T. Kenyon3 on behalf of the Amhara
study group
1 U.S. Centers for Disease Control and Prevention, Atlanta GA USA; 2 Ethiopian Health and Nutrition Research Institute, Addis Ababa, Ethiopia; 3 U.S. Centers for Disease Control and Prevention, Addis Ababa, Ethiopia, 4 Association of Schools of Public Health, Washington, DC, USA; 5Amhara HIV AIDS Prevention and Control Office, Bahir Dar, Amhara, Ethiopia;
6Amhara Health Bureau, Bahir Dar, Amhara, Ethiopia
July 2, 2013
Abstract# TUPDC0103
Prevalence of HIV, HSV-2, and Sexual Risk Behaviors among Secondary
School Students in High Risk Districts in Amhara Region, Ethiopia
Center for Global Health
Division of Global HIV-AIDS
Background and methods
In-school youth in Amhara region, Ethiopia are considered a vulnerable to HIV infection1,2
Cross-sectional bio-behavioral survey Objective: Estimate the prevalence of HIV, HSV2, and
associated risk factors among secondary school students in districts with a high risk of HIV transmission in Amhara
Stratified multistage design. Population: 1338 secondary students15 years of age or older
Setting: Government supported secondary schools in high risk districts
Analyses weighted to account for study design
1Ethiopia HIV/AIDS Prevention & Control Office 20082Mekonnen Y et al2009.
Student Characteristics (N=1317)n (%)
Median age, years [IQR] 17 [16-18]Male 688 (52)Single (Never married) 1252 (95.1)Living with parents/adult relatives 910 (69.1) HIV seropositive 1 (.08)HSV2 seropositive (N=1291) 18 (1.4)Ever had sex 195 (14.6)Median age at sexual debut, years [IQR] 16 (15-18) Sex in the last 18 months 105 (8.1)
Condom use at last sex among those sexually active in last 18 months by partner type (N=105)
Spouse 4 (4)Regular, non-spousal partner 35 (33)Casual partner 48 (46)
Ever tested for HIV 767 (58)Proportion of sexually naïve ever HIV tested (N=1212)
713 (56)
Multivariable AnalysisAdjusted Odds
Ratiop-
value
Younger age at sexual debut*
Marriage 4.0 <0.001
Exposure to school-based prevention programs
.59 0.08
Condom use at last sex¶
Partner type
Spouse referent
Regular non-spouse 14.1 0.01
Casual 33.0 0.01
History of HIV testing
Exposure to school-based prevention programs
1.45 0.03
Increasing age 1.14 <0.01
History of sexual activity 1.78 <0.01
Male sex 0.68 0.01* No association with gender or living with parents/adult relatives¶ No association with age, gender, or exposure to school-based prevention programs
Limitations
Study population is representative of students attending government schools in high risk districts in Amhara Study is not nationally or regionally representative Regions of Ethiopia are highly diverse Students from private or vocational schools were not
recruited
Findings apply to in-school youth only Study did not include out of school youth
Conclusions
Students are not a key population for HIV infection The prevalence of HIV, HSV2, and sex was low among secondary
school students in high risk districts in Amhara
School based interventions have increased HIV testing, but have no effect on condom use and may have a marginal impact on sexual debut
HIV testing is common, even amongst students at low risk or with no history of sex
Students living away from parental supervision are no more likely to engage in sex than those living at home
Recommendations
Students in Amhara do not require the same kind and intensity of interventions as female sex workers, men who have sex with men, etc.
Testing and prevention services should focus on sexually active or high risk students On-campus mass testing campaigns should be
discouraged
Students should receive age-appropriate education regarding sex and HIV
Investigators and institutional affiliations
Ethiopian Health and Nutrition Research Institute Belete Tegbaru, PhD Eshetu Lema Haile, MSc
Amhara HIV and AIDS Prevention and Control Office Ato Eshete Girma Zike , BSc
Amhara Health Bureau Wondimu Gebeyehu Alemu
Amhara Educational Bureau Mulugeta Mesfin
Bahir Dar Health Research Laboratory Center Genetu Alem, BSc MSc
Federal HIV and AIDS Prevention and Control Office Yibeltal Asefa, MD PhD*
CDC-Ethiopia^
Solomon Fekadie Peter Fonjungo, PhD Thomas Kenyon, MD MPH Nora Kleinman, MPH Daniel Rosen, PhD Brent Wolff, PhD*, §
Endale Workalemahu, MD MPH CDC-Atlanta
Marta Ackers, MD MPH Hongjiang Gao, PhD Prabhu Gounder, MD MPH Mahesh Swaminathan, MD* Irum Zaidi, MPH
Family Health International#
Addisu Tessema, M.A Girmachew Mamo, MD MPH¶
* Primary investigator ¶ Study coordinator^ Funding source § Project officer# Implementing partner
For more information please contact Centers for Disease Control and Prevention1600 Clifton Road NE, Atlanta, GA 30333Telephone, 1-800-CDC-INFO (232-4636)/TTY: 1-888-232-6348E-mail: [email protected] Web: www.cdc.gov
The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.
Questions?
References
1Ethiopia HIV/AIDS Prevention & Control Office, Global HIV/AIDS Monitoring and Evaluation Team. HIV/AIDS in Ethiopia - an Epidemiological Synthesis. Global HIV/AIDS Program - Report Series. Washington, DC: World Bank; 2008.
2Mekonnen Y, Daniel G, Solomon S, Degefu A, Tegbaru B. Magnitude of and risk factors for HIV infection among most-at-risk populations (MARPS) in Amhara Region. Addis Ababa, Ethiopia; 2009.
Background1
HIV in Ethiopia (pop. 73.8 million) in 2011 HIV prevalence = 1.5% (1.9% in women, 1.0% in men) HIV in Amhara region
• HIV prevalence = 1.6% (2.2% in women, 1.0% in men,)• HIV prevalence of 4.2% compared to 0.6% in rural areas
HIV prevalence is higher in urban areas/transport corridors (4.2%) then in rural areas (0.6%)
1Central Statistical Agency [Ethiopia], ICF International. Ethiopia Demographic and Health Survey 2011. Addis Ababa, Ethiopia and Calverton, Maryland, USA: Central Statistical Agency and ICF International; 2012.
Background
Ethiopia has rapidly expanded access to formal secondary education Grades 9 to 12 enrolment grew 371,000 in 1994/5 1.7
million in 2009/10. The number of secondary schools grew 369 1,335 in the same time period.2
New schools often built along transport corridors and roadside settlements3 where HIV infection is most concentrated4
1 Dhoj JR, Verspoor A. Secondary Education in Ethiopia: Supporting Growth and Transformation. Washington, D.C: World Bank; 2013.
2 Ministry of Education. Education Statistics Annual Abstract (ESSA), 2003 EC (2010/11 GC). Addis Ababa, Ethiopia: Federal Democratic Republic of Ethiopia Ministry of Education; 2011.
3 Ministry of Education. Education Statistics Annual Abstract (ESSA), 2002 EC (2009/10 GC). Addis Ababa, Ethiopia: Federal Democratic Republic of Ethiopia Ministry of Education (MOE); 2010.
Background
In-school youth are considered a group vulnerable to HIV infection1
A 2008 survey in 5 purposively selected high risk districts in Amhara region found a 12% HIV sero-prevalence among secondary students (N=389)2
Prevalence of 8% among girls, 16% among boys
Amhara officials requested a high quality follow-up study to verify these findings
1Ethiopia HIV/AIDS Prevention & Control Office, Global HIV/AIDS Monitoring and Evaluation Team. HIV/AIDS in Ethiopia - an Epidemiological Synthesis. Global HIV/AIDS Program - Report Series. Washington, DC: World Bank; 2008.
2Mekonnen Y, Daniel G, Solomon S, Degefu A, Tegbaru B. Magnitude of and risk factors for HIV infection among most-at-risk populations (MARPS) in Amhara Region. Addis Ababa, Ethiopia; 2009.
Methods
Primary objective Estimate the prevalence of HIV among secondary school
students in high risk districts in the Amhara Region
Secondary objectives Estimate the prevalence of HSV-2 among secondary
school students in high risk districts in the Amhara Region
Assess demographic, behavioral, structural and environmental factors associated with HIV and HSV-2 infection among secondary students high risk districts in the Amhara Region
Methods
Cross-sectional biological and behavioral survey Behavioral questionnaire Rapid HIV, HSV-2 testing
Study population Age > 15 years Currently enrolled and attending a government-run
secondary school
Setting Government-run secondary schools located in HIV high
risk districts in Amhara region
Methods
High risk districts (N=13) identified in Amhara during mapping exercise Defined as areas of elevated risk of HIV transmission
based on:• HIV testing data from voluntary and counseling (VCT) and
antenatal care (ANC) sites• Presence of known structural risk factors (e.g., sex trade,
truck stops, nearby military bases, etc.)• Key informant interviews
Methods
Stratified multistage design Strata is grade range served by school
• 4 strata: Grade 9 only schools, high schools (grades 9-10), preparatory schools (grades 11-12) and combined schools (9 – 12)
30/42 eligible schools selected Students selected proportional to the gender ratio within
each school
Planned sample size = 1338 Powered to estimate an HIV prevalence = 5% +/- 1.5%
Methods
Behavioral questionnaire administered face to face by trained staff using netbooks
Serum and DBS card collected from each participant On-site rapid HIV test HSV2 test performed on serum at regional reference lab
Analyses were weighted and controlled for survey design Performed with Stata version 10.1
Map of 13 high risk districts in Amhara where study was conducted
School Selection
Participant Enrollment
Student CharacteristicsTotal
(N=1317)Boys
(N=688)Girls
(N=629)n (%) n (%) n (%)
Grade9th 527 (40.0) 247 (35.9) 280 (44.5)10th 420 (31.9) 240 (34.9) 180 (28.6)11th 216 (16.4) 114 (16.5) 103 (16.3)12th 154 (11.7) 87 (12.7) 67 (10.7)
Marital StatusSingle 1252 (95.1) 670 (97.4) 582 (92.6)Married 45 (3.4) 12 (1.7) 33 (5.3)Divorced/
Separated20 (1.5) 6 (0.9) 13 (2.1)
Living Situation With parents/adult relatives
910 (69.1) 436 (63.3) 475 (75.5)
Without parents/adult relative
407 (30.9) 252 (36.7) 154 (24.5)
Mean age, years [95% CI]
17.5 [17.3-17.7] 18.0 [17.7-18.2] 16.9 [16.7-17.1]
Results
HIV prevalence = 0.08% (1/1317) HSV2 prevalence = 1.4% (18/1291)
1.1% girls, 1.5% boys
Results
1317 students agreed to HIV test/interview 1291 agreed to additional HSV2 test Mean age (years) = 17.5 [95% CI: 17.3-17.7] 52% boys, 95% were never married, 69% lived with parents/adult
relative HIV prevalence = 0.08% (1/1317) HSV2 prevalence = 1.4% (18/1291) 14.6% reported ever having sex
Median age sexual debut = 16 (IQR: 15-18) 8.1% reported sex in the 18-month period prior to the study
• Condoms used at last sex by 4% with spouses, 33% with regular partners, and 46% with casual partners
58% ever tested for HIV 56% of sexually naïve students (N=1212) had a history of HIV
testing
Median age sexual debut = 16 (IQR: 15-18) • 16 (IQR: 15-17) for boys, 17 (IQR: 14-18) for girls (p-value =
0.279)
Ever had sex Sex in 18-month period prior to
study
Currently have a sexual partner
0
5
10
15
20
16.1
7.7
3.9
13
8.47.6
14.6
8.1
5.7
Reported sexual activity, all participants (N=1317)
Boys Girls Total
Perc
en
t of
all p
art
icip
an
ts
Most recent sexual partner amongst students who ever had sex (N=195)
40%
38%
6%
16%
Girls (n=85)
12%
36%37%
2%
12%
Boys (n=110)
Spouse Regular Partner Casual PartnerSex Worker Other/Unknown
Use of Condom at Last Sex
History of HIV Testing0
10
20
30
40
50
60
70
80
90
100
3.5
93.8
33.3
85.1
46.4
76.4
Prevention behaviors among partici-pants sexually active in 18-month period
prior to study (N=105)
SpouseRegular PartnerCasual Partner
Perc
en
t of
part
icip
an
ts
56% of sexually naïve students (N=1212) had a
history of HIV testing
Results – Multivariable Analysis
Younger age at sexual debut Marriage: aOR = 4.0, p-value <0.001 Exposure to school based prevention programs: aOR = 0.59, p-
value =0.08 No association with gender or living with parents/adult relatives
Condom use at last sex Partner type (referent = spouse): regular partners aOR = 14.1, p-
value =0.01); casual partners aOR = 33.0, p-value =0.01 No association with age, gender, or exposure to school based
prevention programs History of HIV testing
Exposure to school based prevention programs: aOR =1.45, p-value =0.03
age: aOR = 1.14, p-value<0.01 a history sexual activity: aOR = 1.78, p-value <0.01 male gender: aOR = 0.68, p-value=0.01
Limitations
Study population is representative of students attending government schools in high risk districts in Amhara Study is not nationally or regionally representative Regions of Ethiopia are highly diverse Students from private or vocational schools were not
recruited
Findings apply to in-school youth only Study did not include out of school youth
Conclusions
Students are not a key population for HIV infection The prevalence of HIV, HSV-2, and sex was low among
secondary school students in high risk districts in Amhara School based interventions have increased
HIV testing, but have no effect on condom use and may have a marginal impact on sexual debut
Students living away from parental supervision are no more likely to engage in sex than those living at home
HIV testing is common, even amongst students at low risk or with no history of sex
Recommendations
Students should not receive the same kind and intensity of interventions as female sex workers, men who have sex with men, etc.
Testing and prevention services should focus on sexually active or high risk students On-campus mass testing campaigns should be
discouraged
Students should receive age-appropriate education regarding sex and HIV