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MON

MONDAY, APRIL 22

Across Societies – Experimental Biology

Critiquing of CV/Resumes is by appointment and starts at 9:30 AM on Sunday and continues until 5:00 PM on Wednesday. Sign up on-site in the EB2013/FASEB Career Center, Hall B.

9:15 Goal setting, prioritizing, time management. H. Adams.9:15 NIH career development (K) award programs and early-

stage investigators. H Khachaturian.9:30 Economics and your job search. J. Tringali.9:30 Managing a lab. S. Milgram, L. Conlan.11:00 Compensation negotiation for scientists moving into

industry,. B. Lindstaedt.11:00 Sometimes it’s who you know: winning at networking. J.

Blumenthal.11:00 The academic job search in the life sciences: part 1. A.

Green.11:00 Developing your core message/elevator pitch. J.

Lombardo.11:00 The federal job hunt. S. Milgram, L. Conlan.1:00 The academic job search in the life sciences: part 2. A.

Green.1:00 Ten tough industrial interview questions: ten good

responses. J. Tringali.1:00 Making the case for graduate school. H. Adams.1:00 Managing up. S. Milgram, L. Conlan.1:30 Ten ways to get lucky in the job search. P. Clifford, J.

Lombardo.2:00 Careers in science education and outreach. S. Milgram,

L. Conlan.2:30 The job talk. A. Green.3:00 Job hunting in the biotech industry setting. B. Lindstaedt.3:00 Negotiation strategies for scientists. D. Behrens.3:00 Transforming your CV. N. Saul.3:00 Training at the NIH. S. Milgram, L. Conlan.4:00 Making the connection - resume, the interview and the

job. J. Blumenthal.

186. NIH K AWARDS

Seminar

mon. 9:15 am—Boston Convention & exhiBition Center, hall B, Career Center area

Chaired: h. KhaChaturian, niGms, nih

NIH Grants Seminar Workshop Series

Career Development

This presentation will focus on the NIH’s Career Development Awards (K) including the most recent K99/00 Pathways to Independence Award (for postdoctoral scientists) and other K awards targeted to individuals with research doctoral degrees (Ph.D. and equivalent) and clinical doctoral degrees (M.D. and equivalent). Among the K awards discussed will be the K01 Mentored Research Scientist Development Award, the K02 Independent Scientist Award, the K22 Career Transition Award, the K08 Mentored Clinical Scientist Development Award, the K23 Mentored Patient Oriented Career Development Award, the K24 Mid-Career patient Oriented Career Award, and K25 Mentored Quantitative Scientist Career Development Award. The interactive discussion will give attendees an opportunity to ask questions of and obtain insight from an NIH representative on these and other awards available for beginning investigators.

187. CAREER DEVELOPMENT SEMINARS AND WORKSHOPS

Workshop

mon. 9:00 am—Boston Convention & exhiBition Center, hall B, Career Center area

Career Development

The following Seminars and Workshops will be held in the EB2013/FASEB Career Center. There is no fee or pre-registration associated with the workshops and seminars; just walk in and sit down!

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Anatomy

188. ANATOMICAL SCIENCES EDUCATION: THE FUTURE

Plenary

mon. 8:00 am—Boston Convention & exhiBition Center, 104aB

CoChaired: r. DraKe anD W. paWlina

Education & Teaching

Professional Development

8:00 188.1 Anatomy as a garden of educational delights: medical education, professional formation, and the hidden curriculum. F.W. Hafferty. Mayo Clin.

9:00 188.2 Longitudinal integrated clerkship training as a model for basic science education. D. Hirsh. Harvard Med. Sch.

189. PALEONTOLOGY AND FUNCTIONAL ANATOMY

Plenary


CoChaired: J. laitman anD J. orGan

10:30 Joseph Leidy would be very proud: 125 years of progress in paleontology and functional anatomy. J. Laitman. Mount Sinai Sch. of Med.

10:50 189.1 The Visible Interactive Dinosaur project: fleshing out dinosaur head anatomy and function with advanced 3D imaging. L.M. Witmer. Ohio Univ. Col. of Osteo. Med.

11:20 189.2 The evolution of human anatomy and locomotion. C.V. Ward. Univ. of Missouri-Columbia.

11:50 189.3 Integrative experimental approaches to adaptive interpretations of the fossil record. M.J. Ravosa. Univ. of Notre Dame.

12:20 Discussion.

190. DEVELOPMENT AND REPROGRAMMING OF VASCULAR SMOOTH MUSCLE

Symposium

mon. 2:30 pm—Boston Convention & exhiBition Center, 102aB

Chaired: C. little

Developmental Biology

Cardiovascular

2:30 190.1 Development and diversity of vascular smooth muscle progenitors. M.W. Majesky. Univ. of Washington.

3:00 190.2 Vascular extracellular matrix and aortic cell differentiation. R. Mecham. Washington Univ. Sch. of Med.

3:30 190.3 Reprogramming of vascular smooth muscle cells into calcifying cells: what can we learn from the embryo? H. Kempf. INSERM, Vandoeuvre-les-Nancy.

191. REFRESHER COURSE: HISTOLOGY TEACHING — PAST, PRESENT AND FUTURE

Symposium

(Supported by an educational grant from MBF Bioscience)


CoChaired: r. oGilvie anD r. mCCusKey

Education & Teaching

2:30 Chair’s introduction.2:35 191.1 The history of medical histology teaching:

where have we come from and where are we going? R.A. Bloodgood. Univ. of Virginia Sch. of Med.

3:00 191.2 Teaching histology in integrated curricula: challenges and opportunities. H. Amerongen. Univ. of Arizona.

3:25 191.3 A modern distributed learning histology course with virtual lectures and labs. R. Ogilvie and R. Sawyer. Univ. of South Carolina and Med. Univ. of South Carolina.

3:50 Discussion.

192. COMPARATIVE PERSPECTIVES ON THE HUMAN FACE: BIOMEDICAL IMPLICATIONS OF EVOLUTIONARY ANATOMICAL RESEARCH

Symposium

(Cosponsored by: The Anatomical Record)

mon. 2:30 pm—Boston Convention & exhiBition Center, 104C

Chaired: a. BurroWs

2:30 Chair’s introduction.2:35 192.1 Comparative anatomy of mammalian and

primate facial muscles and evolutionary genetics of atavistic muscles in humans with trisomy. J. Ziermann, R. Diogo and N. Bhatia. Howard Univ.

3:00 192.2 Neuroanatomical causes and social consequences of variation in facial motor control: what comparative primatology can teach us about autism spectrum disorders. S. Dobson. Dartmouth Col.

3:25 192.3 How good are mice and monkeys as models for human face transplants? Comparative physiological perspectives on myosin fiber types. A.M. Burrows, E.L. Durham, L.C. Matthews, T.D. Smith and L.A. Parr. Duquesne Univ., Univ. of Pittsburgh, Slippery Rock Univ., Emory Univ. and Yerkes Natl. Primate Res. Ctr., Atlanta.

3:50 Discussion.

ANATOMY MONDAY

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193. TISSUE INJURY, STEM CELLS AND REGENERATIVE MEDICINE

Platform

mon. 2:30 pm—Boston Convention & exhiBition Center, 105

Chaired: m. DunnWalD

Regeneration/Tissue Engineering

2:30 193.1 The Pitx2:miR-200 family axis regulates WNT and BMP signaling during tooth morphogenesis and renewal. X. Li, H. Cao, A. Jheon, Z. Sun, J. Wang, O. Klein and B.A. Amendt. Univ. of Iowa and UCSF.

2:45 193.2 Osteogenic differentiation of mesenchymal stem/stromal cells within 3D bioprinted neotissues. A.J. Evinger, J.M. Jeyakumar, L.A. Hook, Y. Choo, B.R. Shepherd and S.C. Presnell. Organovo Inc., San Diego, Plasticell Ltd., London and Tissue Applications Gp., San Diego.

3:00 193.3 Sensory neurons accelerate reepithelialization through substance P release in an innervated tissue-engineered model of skin wound healing. M. Blais, L. Mottier, S. Cadau, R. Parenteau-Bareil and F. Berthod. Laval Univ., Canada.

3:15 193.4 Is salamander limb regeneration really perfect? First detailed anatomical and morphogenetic analysis of forelimb muscle regeneration in GFP-transgenic axolotls as a basis for regenerative, developmental and evolutionary studies. R. Diogo and E. Tanaka. Howard Univ. and Ctr. for Regen. Therapies, Dresden, Germany.

3:30 Breast milk is a novel source of stem cells with multi-lineage differentiation potential. F. Hassiotou, L. Filgueira and P.E. Hartmann. Univ. of Western Australia and Univ. of Fribourg, Switzerland. (21.2)

3:45 193.5 Intrinsic pluripotent stem cells, Muse cells, are a primary source of iPS cells in human fibroblasts. M. Dezawa. Tohoku Univ., Japan.

194. AAA KEYNOTE LECTURE

(Supported by an educational grant from AACBNC)


4:30 194.1 Evo-devo and an expanding evolutionary synthesis. S.B. Carroll. , Bethesda.

195. AAA BUSINESS MEETING


196. AAA STUDENT/POSTDOCTORAL POSTER RECEPTION

Special Function

mon. 6:30 pm—Boston Convention & exhiBition Center, northWest loBBy a

Biochemistry and Molecular Biology

197. ASBMB BOSTON TEA PARTY: UNDERGRADUATE BREAKFAST SESSION WITH OLKE C. UHLENBECK

Special Session

(Supported by an educational grant from the National Science Foundation)

mon. 7:00 am—Boston Convention & exhiBition Center, 255

Advance event registrants receive priority seating. All other undergraduates will be accommodated as space permits.

198. ASBMB YOUNG INVESTIGATOR AWARD LECTURE

Award

mon. 8:30 am—Boston Convention & exhiBition Center, 258a

8:30 Introductory remarks. J. M. Berg.8:35 198.1 GTPase and ATPase tangos during intracellular

protein targeting. S-o. Shan. Caltech.

199. ASBMB-MERCK AWARD LECTURE

Award

(Supported by an educational grant from Merck)


9:05 Introductory remarks. S. Emr.9:10 199.1 Biogenesis of transport carriers. V. Malhotra.

Ctr. for Genomic Regul., Barcelona.

200. MECHANISMS AND CONTROL OF REPLICATION INITIATION

Symposium


Chaired: v. zaKian

9:55 Chair’s introduction.10:00 200.1 Forkhead (Fox) transcription factors open

a new dimension in understanding the epigenetic control of replication origins in S. cerevisiae. O. Aparicio, S.R.V. Knott, Z.A. Ostrow, J.M. Peace, Y. Gan, R. Kalhor, L. Chen and S. Tavaré. Univ. of Southern California.

10:25 Mapping DNA replication origins in the human genome. S.A. Gerbi, J. Urban and M. Foulk. Brown Univ. (759.1)

MONDAY ANATOMY/BIOCHEMISTRY

54

10:40 200.2 Controlling genome integrity via posttranslational regulation of the eukaryotic replisome. K. Labib. Univ. of Manchester.

11:05 Modulation of Mcm2-7 activity by Cdt1. L.F. DaSilva, T. Kolaczyk, X. Ma and M.J. Davey. Univ. of Western Ontario. (539.2)

11:20 Functional characterization of Dbf4 interactions with DNA replication and checkpoint factors. D.R. Jones, L.A. Matthews, B.J. McConkey, A. Guarné and B.P. Duncker. Univ. of Waterloo and McMaster Univ., Canada. (542.10)

11:35 200.3 Mechanism of eukaryotic helicase loading and activation. S.P. Bell, S. Kang, S. Ticau and B.S.H. Chan. MIT/HHMI.

12:00 Discussion and closing remarks.

201. MAKING AND USING RNA IN THE NUCLEUS

Symposium


Chaired: J. Coller

9:55 Chair’s introduction.10:00 201.1 Telomerase holoenzyme assembly. K. Collins.

Univ. of California, Berkeley.10:25 Insights into splicing: structure of the yeast U1 snRNP.

C. van der Feltz, N. Grigorieff and D. Pomeranz Krummel. Brandeis Univ. and HHMI, Chevy Chase, MD. (988.5)

10:40 201.2 Regulation of alternative splicing. K. Hertel, W. Mueller, A. Busch, S. Erkelenz and H. Schaal. Univ. of California, Irvine and Heinrich Heine Univ., Germany.

11:05 NOL11, implicated in the pathogenesis of North American Indian childhood cirrhosis, is required for pre-rRNA transcription and processing. S. Baserga, E. Freed, J-L. Prieto, K. McCann and B. McStay. Yale Sch. of Med. and Natl. Univ. of Ireland Galway. (552.1)

11:20 A highly conserved GC-rich element regulates alternative splicing of mRNA for the variant thyroid hormone receptor, TRa2. S.H. Munroe. Marquette Univ. (775.2)

11:35 201.3 Mechanisms for regulating splicing through signaling pathways. K.W. Lynch. Univ. of Pennsylvania.


202. LIPID MEMBRANE CURVATURE IN MEMBRANE FUNCTION

Symposium

(Supported by an educational grant from Avanti Polar Lipids, Inc.)


Chaired: J. lippinCott-sChWartz

9:55 Chair’s introduction.10:00 202.1 Spatiotemporal control of endocytosis by

phosphatidylinositol 3,4-bisphosphate. V. Haucke and Y. Posor. Leibniz Inst. for Molec. Pharmacol., Berlin.

10:25 Investigating the molecular basis of cPLA2a membrane bending. K.E. Ward, J.P. Ropa and R.V. Stahelin. Univ. of Notre Dame and Indiana Univ. Sch. of Med. at South Bend. (587.3)

10:40 202.2 Separation of time-scales in the functional biophysics of bar domain proteins. T. Baumgart. Univ. of Pennsylvania.

11:05 Novel role of cytohesin-2 in regulation of macropinocytosis pathway and cell proliferation. V. Marshansky, H. Hosokawa, Z. Zhuang, P.A. Randazzo, G. Grüber and D.A. Ausiello. Massachusetts Gen. Hosp., Harvard Med. Sch., NCI, NIH and Nanyang Tech. Univ., Singapore. (591.8)

11:20 The Coffin-Lowry syndrome-associated protein RSK2 regulates neurite outgrowth through phosphorylation of PLD1 and synthesis of phosphatidic acid, a membrane curving fusogenic lipid. N. Vitale, M.R. Ammar and M-F. Bader. CNRS UPR-3212, Strasbourg. (587.1)

11:35 202.3 Exocytic and endocytic mechanisms: discovering a role for membrane curvature and curvature stress. H.T. McMahon. MRC Lab. of Molec. Biol., Cambridge, U.K.


203. CATALYTIC AND SUBSTRATE PROMISCUITY

Symposium

mon. 9:55 am—Boston Convention & exhiBition Center, 253C

Chaired: s. Copley

9:55 Chair’s introduction.10:00 203.1 Multiple catalytic promiscuity: specificity and

efficiency in the alkaline phosphatase superfamily. F. Hollfelder. Univ. of Cambridge, U.K.

10:25 Substrate specificity of Rv0045c, a bacterial esterase from Mycobacterium tuberculosis. C.P. Savas, A. Gehring, R.J. Johnson and G. Hoops. Butler Univ. (559.2)

10:40 203.2 Enzyme recruitment and the evolution of new metabolic potential. B.G. Miller. Florida State Univ.

11:05 The role of modulator residues in PDZ domain binding interactions. J. Amacher, P.R. Cushing, L. Brooks, P. Boisguerin and D.R. Madden. Dartmouth Col. and Inst. of Med. Immunol., Berlin. (559.6)

11:20 Tracking GPCR promiscuity at the source: how receptor conformation is translated to differential function. S. Sivaramakrishnan and R.U. Malik. Univ. of Michigan. (559.5)

11:35 203.3 The remarkable pliability and promiscuity of specialized metabolism. J.P. Noel. Salk Inst./HHMI.


204. PROTEIN PHOSPHORYLATION NETWORKS

Symposium

mon. 9:55 am—Boston Convention & exhiBition Center, 253B

Chaired: C. lanGe

9:55 Chair’s introduction.10:00 204.1 Signaling by the cJun NH2-terminal kinase.

R.J. Davis. HHMI and Univ. of Massachusetts Med. Sch.10:25 A BRAF-MEK complex reveals the molecular

basis of oncogenic mutations. S.G. Hymowitz, J. Sudhamsu, J. Haling, A. Peck, I. Yen, T. Morales, B. Brandhuber and S. Malek. Genentech, South San Francisco and Array BioPharma, Boulder. (1031.11)

10:40 204.2 Proteomics and the control of MAP kinase dynamics. N. Ahn, Y. Xiao, T. Lee, L. Warner, M. Latham, A. Tanimoto, W. Peti, R. Page and A. Pardi. Univ. of Colorado Boulder and Brown Univ.

BIOCHEMISTRY MONDAY

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MON

11:05 Investigating inactive conformations of protein kinases. S.B. Hari, B.G.K. Perera, S.E. Leonard and D.J. Maly. Univ. of Washington. (1042.1)

11:20 The dark side of protein kinases: FRET toolbox illuminates a hidden conformation in PKC catalysis. C.J. Swanson, M. Ritt, B. Udarasayan, W. Wang, M. Westfall and S. Sivaramakrishnan. Univ. of Michigan. (597.3)

11:35 204.3 Novel secreted protein kinases. J.E. Dixon. HHMI, Chevy Chase, MD and UCSD.


205. TRANSITIONING FROM STUDENT TO PROFESSIONAL

Symposium


Chaired: o. Finn

9:55 Chair’s introduction.10:00 205.1 The first big leap, college to graduate school.

P.J. Kennelly. Virginia Tech.10:25 Student conceptions and misconceptions

about energy transformations in biochemistry. A.J. Wolfson, S.L. Rowland, G.A. Lawrie and T.H. Wright. Wellesley Col. and Univ. of Queensland, Australia. (838.3)

10:40 205.2 NIH support of pre- and postdoctoral training for a career as a research scientist. R.E. Ulane. OD, NIH.

11:05 The Pre-health Collection within MedEdPORTAL’s iCollaborative: faculty resources to prepare students for the MCAT2015. H.V. Jakubowski and L.S. Zapanta. Col. of Saint Benedict, St. John’s Univ., MN and Univ. of Pittsburgh. (838.2)

11:20 A certificate program to help bachelor’s degree graduates transition into careers in the bioscience industry. M. Wallert and J. Provost. Minnesota State Univ. Moorhead. (838.15)

11:35 205.3 The presidential postdoctoral program at Novartis Institutes for BioMedical Research. L. Pond. Novartis Insts. for BioMed. Res.


206. ASBMB CERTIFICATION PROGRAM FOR BACHELOR’S DEGREES IN BIOCHEMISTRY, MOLECULAR BIOLOGY AND RELATED MAJORS

Symposium


ASBMB has initiated the roll-out of an outcomes-based degree certification program for undergraduates majoring in Biochemistry, Molecular Biology, and related majors. The objectives of the program are to recognize student accomplishment and provide faculty with tools and data to help foster quality education and leverage needed resources. For this program to be successful, the participation of and feedback from members of the educational community is essential. Members of the working group responsible for developing the bachelor’s degree accreditation program will briefly describe the structure and rationale behind version 1.0 of the program, answer questions from the audience and receive community feedback.

207. ALICE AND C.C. WANG AWARD IN MOLECULAR PARASITOLOGY SYMPOSIUM

Award

mon. 12:30 pm—Boston Convention & exhiBition Center, 258a

12:30 Introductory remarks. K. Kam and M. Phillips.12:35 207.1 Amino acid utilization in intraerythrocytic

malaria parasites. D.E. Goldberg. HHMI/Washington Univ.1:05 207.2 Scent of a parasite: isoprenoids in malaria.

A.R. Odom. Washington Univ. Sch. of Med.1:35 207.3 What do human parasites do with a chloroplast

anyway? B. Striepen. Univ. of Georgia.2:05 Conclusion.

208. FROM THE LAB TO THE KITCHEN TABLE – COMMUNICATING SCIENCE TO A LAY AUDIENCE

Workshop

(Sponsored by: ASBMB Public Outreach Committee)


CoChaired: h. alexanDer anD t. BalDWin

Outreach can come in a wide variety of flavors. Come get a taste during our interactive roundtable session.

• “Science and Me” – a student-driven science outreach program for adult audiences H. Alexander, Univ. of Missouri-Columbia

• Takin’ It to the Streets P.A. d’Arbeloff Cambridge Sci Fest

• Learning to Communicate—A Graduate Training Course in Science Communication T. Baldwin Univ. of California, Riverside

• Community-Based Projects That Complement Learning in a Biochemistry Course J. Dattelbaum Univ. of Richmond

• The Science & Entertainment Exchange: 1-800-I-Need-a-Scientist! A. M. Merchant The Science and Entertainment Exchange

• FameLab: Communicating Your Science D. M. Scalice NASA Astrobiology Inst.

• Do-it-Yourself: Building the Voice of Young Science, M. Thompson, Harvard Univ

209. DELANO AWARD FOR COMPUTATIONAL BIOSCIENCES LECTURE

Award


2:55 Introductory remarks. A. Stock.3:00 209.1 PDB as a public resource for enabling protein

science. H.M. Berman. Rutgers, The State Univ. of New Jersey, Piscataway.

MONDAY BIOCHEMISTRY

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210. TRANSCRIPTION MECHANISMS

Symposium

mon. 3:45 pm—Boston Convention & exhiBition Center, 252a/B

Chaired: r. KinGston

3:45 Chair’s introduction.3:50 210.1 Post-initiation roles for the sigma subunit of

bacterial RNA polymerase. A. Hochschild, P. Deighan, N. Nair, K. Berry, S. Goldman and B. Nickels. Harvard Med. Sch. and Rutgers Univ., Piscataway.

4:15 The X-ray crystal structure of Escherichia coli RNA polymerase s70 holoenzyme. K. Murakami. Penn State. (547.2)

4:30 210.2 Proteomic analysis of Pol II preinitiation complexes: the roles of mediator and saga. M. Carey. UCLA.

4:55 Capturing the transient, in vivo binding partners of transcriptional activators using a genetically incorporated photo-crosslinking amino acid. A. Dugan and A.K. Mapp. Univ. of Michigan. (550.15)

5:10 Characterization of the interaction between Rrn3 and rpa43: identification of a peptide that inhibits rDNA transcription and cell growth. L. Rothblum, Y. Penrod and K. Rothblum. Univ. of Oklahoma Hlth. Sci. Ctr. (549.3)

5:25 210.3 Analysis of RNA polymerase II transcription initiation and elongation complexes. S. Buratowski. Harvard Med. Sch.


211. GLYCOSYLTRANSFERASES THAT CONTROL CELL GROWTH AND DIFFERENTIATION

Symposium


Chaired: l. Wells

3:45 Chair’s introduction.3:50 211.1 Molecular regulation of protein O-glycosylation

and relevance to disease and development. R.D. Cummings, Y. Wang and T. Ju. Emory Univ. Sch. of Med.

4:15 ST6Gal-i-mediated sialylation of Fas and TNFR1 controls receptor localization and apoptotic signaling. M.J. Schultz, A.F. Swindall, Z. Liu and S.L. Bellis. Univ. of Alabama at Birmingham. (592.3)

4:30 211.2 Roles for glycans in mammalian development and spermatogenesis. P. Stanley, F. Batista and H-H. Huang. Albert Einstein Col. of Med.

4:55 A regulator of complex and hybrid N-glycan synthesis expressed mainly in testis. F. Batista, H-H. Huang and P. Stanley. Albert Einstein Col. of Med. (824.1)

5:10 The sialyltransferase, ST3Gal4, protects against pressure-induced cardiac hypertrophy. E.S. Bennett, W. Deng and J. Qi. Univ. of South Florida Morsani Col. of Med. (595.2)

5:25 211.3 Homeostatic control of cell growth and differentiation by Golgi proofreading. M. Demetriou and H. Mkhikian. Univ. of California, Irvine.


212. THE MULTIVESICULAR BODY AND ENDOCYTOSIS

Symposium


Chaired: B. sChulman

3:45 Chair’s introduction.3:50 212.1 Mechanism of dynamin-catalyzed membrane

fission. S.L. Schmid, S. Neumann, Y-W. Liu and J-P. Mattila. Univ. of Texas Southwestern Med. Ctr. and The Scripps Res. Inst.

4:15 Casein kinase 1d/ε regulates clathrin- and actin-mediated endocytosis. Y.C. Peng, A. Grassart, R. Lu, A. Michelot, C. Wong, J. Yate III, G. Barnes and D. Drubin. Univ. of California, Berkeley and The Scripps Res. Inst. (553.25)

4:30 212.2 ESCRTing receptor downregulation: assembly and function of the ESCRT-III complex. S.D. Emr, N. Buchkovich and M.M. Henne. Cornell Univ.

4:55 Polarized release of TCR-enriched microvesicles at the center of the T cell immunological synapse. M. Dustin. NYU Sch. of Med. (553.24)

5:10 Landscape of the PARKIN-dependent ubiquitin modified proteome in response to mitochondrial depolarization defined through quantitative proteomics. S.A. Sarraf, M. Raman, V. Guarani-Pereira, M.E. Sowa, E.L. Huttlin, S.P. Gygi and J.W. Harper. Harvard Med. Sch. (553.17)

5:25 212.3 The ESCRT pathway in HIV budding and cytokinesis. W.I. Sundquist. Univ. of Utah.


213. CONTROLLING CELLULAR COMMUNICATION

Symposium


Chaired: a. mapp

3:45 Chair’s introduction.3:50 213.1 Disrupting bacterial communication to

suppress multidrug resistant phenotypes. C. Melander. North Carolina State Univ.

4:15 Structure activity relationship study of the cleistriosides and cleistetrosides for antibacterial/anticancer activity. P. Shi. Northeastern Univ. (1014.7)

4:30 213.2 Small molecules, toxins and cell death pathways. D.T. Hung. Harvard Med. Sch./Broad Inst./Massachusetts Gen. Hosp.

4:55 Single clone expression cloning and protein microarray platforms for novel extracellular receptor-ligand identification. I. Tom, G. Quinones, A. Estevez, M. Paluch, K. Bowman, Y. Franke, K. Billeci, P. Hass, J. Tang, N. Lewin-Koh, D. Eaton, J-P. Stephan and L. Gonzalez. Genentech. (803.5)

5:10 A small optogenetic tool for spatiotemporal control of intracellular cAMP. C.P. O’Banion and D.S. Lawrence. Univ. of North Carolina at Chapel Hill. (566.1)

5:25 213.3 Signals from the surface to control cell fate decisions. L.L. Kiessling. Univ. of Wisconsin-Madison.


BIOCHEMISTRY MONDAY

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214. BACK TO BASICS: THE BIOLOGY OF BREAST CANCER

Symposium

mon. 3:45 pm—Boston Convention & exhiBition Center, 253B

Chaired: G. thomas

3:45 Chair’s introduction.3:50 214.1 Exosomal media enhances proliferation,

migration, and invasion in triple negative breast cancer. K. Parker Johnson, D.C. Stoute, L. Yearby, G. Beverly, E. Skripnikova and J. Ochieng. Col. of Pharm., Xaiver Univ. of LA and Meharry Med. Col.

4:15 The green tea polyphenol EGCG induces mesenchymal to epithelial transition and tumor regression in triple negative breast cancer cells and mouse-xenograft model: involvement of CCN5. A. Das, S. Banerjee, A. De, I. Haque, G. Maity, M. McEwen and S.K. Banerjee. VA Med. Ctr., Kansas City, MO and Univ. of Kansas Med. Sch. (610.2)

4:30 214.2 Novel targets in advanced breast cancer in African American patients. S. Ambs. NCI, NIH.

4:55 ADAM12: a novel mediator of tumor angiogenesis. R. Roy and M. Moses. Boston Children’s Hosp. and Harvard Med. Sch. (609.1)

5:10 Novel strategy for lineage tracing of cancer stem cells. T.M. Nguyen, E.C. Chang and J.M. Rosen. Wabash Col. and Baylor Col. of Med. (609.2)

5:25 214.3 High risk CNIs, race and early stage breast cancer. P.A. Thompson, A. Brewster, K-A. Do, A.A. Sahin, G. Mills and M. Bondy. Univ. of Arizona Cancer Ctr., Univ. of Texas MD Anderson Cancer Ctr. and Baylor Col. of Med.


215. TRAINING FOR A WORLD IN TRANSITION

Symposium


Chaired: p. J. Kennelly

3:45 Chair’s introduction.3:50 215.1 Developing the nation’s human capital in STEM

for tomorrow. J. Ferrini-Mundy. Natl. Sci. Fndn.

4:15 A metabolic pathways diagnosis test for assessing the development of biochemistry students’ visualization skills. E. Galembeck, V.J.S.V. dos Santos and T. Anderson. UNICAMP, Campinas, Brazil, Purdue Univ. and Fed. Univ. of São João, Brazil. (838.5)

4:30 215.2 Ramping up for STEM success: new models for transfer. S. Albertine. Assn. of Amer. Cols. And Univs., Washington, DC.

4:55 Developing a robust POGIL model to connect basic biochemistry to the physiological changes during starvation. D. Dean and E. Anderson. Univ. of Saint Joseph, CT. (613.3)

5:10 An inexplicable disease—prion disease as a ‘choose-your-own-experiment’ case to introduce students to scientific inquiry. J.K. Hines, A. Serrano and S. Miller. Lafayette Col., PA and Univ. of Wisconsin-Madison. (612.3)

5:25 215.3 Educating students for an interdisciplinary world. L.A. Kuhn. Michigan State Univ.


216. ASBMB THEMATIC FERMENTATION HOUR

Special Event

mon. 6:00 pm—Boston Convention & exhiBition Center, northeast Foyer

Join fellow biochemists and molecular biologists for continued scientific discussion following the afternoon sessions. Enjoy a cool beverage and casual atmosphere.

217. ASBMB SCIENCE CAFÉ: THE NEW SOCIAL NETWORKING EVENT

Special Event

mon. 7:00 pm—Westin Boston WaterFront hotel, sauCiety restaurant

Ever wondered where in the universe another Earth-like planet might be? What would such a planet look like? Is there the possibility of life? Join us for a discussion of these and other fascinating questions at the ASBMB Science Café with C. Dressing, Harvard-Smithsonian Ctr. for Astrophysics.

Experimental Biology exhibitors offer the best tools and resources available in research today!

Join the exhibitors at 10:00 am for coffee and 2:00 pm for snacks and learn the latest and greatest from more than 300 companies.

MONDAY BIOCHEMISTRY

58

Nutrition220. THE WORLD HAS CHANGED AND SO MUST

YOUR COMMUNICATION STYLE

Symposium

(Sponsored by: Public Information Committee and the Public Policy Committee)


Chaired: C. KapiCa

CoChaired: J. GazzaniGa-moloo

Education Track/Professional Development

Career Development

8:00 Introduction.8:15 The new world of nutrition science communications. C.

Kapica. The Awegrin Inst.8:50 Techniques for getting to the point in 3 minutes or less.

M. McGuire. Washington State Univ.9:25 Techniques for getting to the point in 3 minutes or less.

L. Troy. Univ. of Massachusetts Amherst.

221. FOOD ENVIRONMENT AND POLICY

Minisymposium

(Sponsored by: Community and Public Health Nutrition RIS)


Chaired: s. ColBy

CoChaired: p. Keane

8:00 221.1 Improving access in food deserts: a case study in an urban midwestern neighborhood. C.A. Gibson, D. Endicott and C.C. Pritchard. Univ. of Kansas Med. Ctr. and Good Natured Family Farms, Kansas City.

8:15 221.2 The energy content of restaurant foods without stated calorie information. L.E. Urban, A.H. Lichtenstein, C.E. Gary, J.L. Fierstein, A. Equi, C. Kussmaul, G.E. Dallal and S.B. Roberts. USDA at Tufts Univ.

8:30 221.3 Where do children get food? Building a searchable, visual database of food sources through ground-truthing. H. Coakley, A. Zablotny, Y.S. Cheah, Y. Mui, E.A. Steeves, G. Glass, A. Hackman, M. Sherman and J. Gittelsohn. Johns Hopkins Bloomberg Sch. of Publ. Hlth.

8:45 221.4 Impact of national policy banning TV advertisement on high-energy/low-nutrient foods. S-K. Lee, S-Y. Nam, B.J. Yoon and S-J. Chung. Inha Univ., Seoul Natl. Univ. and Kookmin Univ., South Korea.

9:00 221.5 Do front-of-pack nutrition rating systems and symbols (FOPS) direct consumers to the healthiest products in an unregulated environment? T. Emrich and M. L’Abbe. Univ. of Toronto.

9:15 221.6 Adaptation of the Nutrition Environment Measures Survey-Stores to assess a Mexican/Mexican-American nutrition environment. D.M. Winham and S. Szkupinski Quiroga. Howell Res. Assocs LLC, Queen Creek, AZ and Arizona State Univ.

218. SEARCHING FOR THE EVIDENCE THAT LINOLEIC ACID FUELS INFLAMMATION

Symposium

(Sponsored by: Medical Nutrition Council)

(Supported by an educational grant from The Beef Checkoff)

mon. 8:00 am—Boston Convention & exhiBition Center, Ballroom east

Chaired: m.a. Belury

CoChaired: J. Finley

Nutrition and Inflammation

8:00 Does linoleic acid fuel inflammation? The pro perspective. C. Ramsden. U.S. Publ. HHh. Svc.

8:30 Linoleic acid and inflammation: a hypothesis without fuel. W. C Willett. Harvard Sch. of Publ. Hlth.

9:00 Putting out the fire: evidence that linoleic acid-rich vegetable oils have anti-inflammatory effects. M. A. Belury. The Ohio State Univ.

9:30 New innovations in “designer” vegetable oils – less PUFA and SFA, and more MUFA. Are there health benefits? P. M. Kris-Etherton. Penn State.

219. GLOBAL PERSPECTIVES ON PRETERM BIRTH AND FETAL GROWTH RESTRICTION: MATERNAL AND NUTRITIONAL INFLUENCES

Symposium

(Sponsored by: Global Nutrition Council)

(Supported by an educational grant from CHERG with the Support of the Bill and Melinda Gates Foundation)

mon. 8:00 am—Boston Convention & exhiBition Center, 157aBC

Chaired: e. piWoz

CoChaired: r. BlaCK

Pediatric Nutrition and Early Development

8:00 Introductory comments. R. Black. Johns Hopkins Univ. Bloomberg Sch. of Publ. Hlth.

8:05 Contribution of preterm birth and FGR to infant mortality – global and regional disease burden estimates. J. Katz. Johns Hopkins Univ. Bloomberg Sch. of Publ. Hlth.

8:25 Contributions of preterm birth and FGR to childhood undernutrition. P. Christian. Johns Hopkins Univ. Bloomberg Sch. of Publ. Hlth.

8:45 Maternal nutrition and other risk factors of preterm birth and FGR. A. C. Lee. Brigham and Women’s Hosp.

9:05 RCT of antenatal vitamin A and zinc and birth outcomes in Tanzania – mechanisms related to angiogenesis. W. Fawzi. Harvard Sch. of Publ. Hlth.

9:25 RCT of antenatal micronutrients and endocrine and fetal growth factors in Bangladesh. A. Gernand. Univ. of Pittsburgh.

9:45 Q&A.

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9:30 221.7 Modeling the impact of revisions to daily values assuming that current % daily values in fortified foods are maintained. M.M. Murphy, J.H. Spungen, L.M. Barraj, R.L. Bailey and J. Dwyer. Exponent Inc., Washington, DC, ODS, NIH and USDA and Sch. of Med., Tufts Univ.

9:45 221.8 How does household composition affect purchases of grain-based desserts? K.C. Mathias, S.W. Ng and B.M. Popkin. Univ. of North Carolina at Chapel Hill.

222. NUTRIENT-GENE INTERACTIONS: LIPIDS

Minisymposium

(Sponsored by: Nutrient-Gene Interactions RIS)


Chaired: J. Davis

8:00 222.1 Interaction effects between n-3 polyunsaturated fatty acids and genetic variations in genes involved in de novo lipogenesis on plasma triglyceride levels. A. Bouchard-Mercier, I. Rudkowska, S. Lemieux, P. Couture and M-C. Vohl. Laval Univ., Canada.

8:15 222.2 Creatine supplementation may prevent NAFLD by stimulating fatty acid oxidation. R.L. Jacobs, R. da Silva and R. Nelson. Univ. of Alberta.

8:30 222.3 Specificity factor 1 mediates transcriptional induction of Atp7a during hypoxia in rat intestinal epithelial (IEC-6) cells. L. Xie and J.F. Collins. Univ. of Florida.

8:45 222.4 Genome-wide contribution of genotype by environment interaction to blood lipid variation. C-Q. Lai, D.K. Arnett, K. Richardson, L.D. Parnell, I.B. Borecki and J.M. Ordovas. USDA at Tufts Univ., Univ. of Alabama at Birmingham and Washington Univ. Sch. of Med.

9:00 222.5 Clock 3111 T/C SNP interacts with saturated fatty acid intake to modulate plasma LDL-C concentrations in the Boston-Puerto Rican Health Study. H.S. Dashti, K.L. Tucker, C.E. Smith, Y. Ma, Y-C. Lee and J.M. Ordovás. USDA at Tufts Univ. and Northeastern Univ.

9:15 222.6 Gamma-tocotrienol antagonizes adipogenesis through activation of AMPK/autophagy axis in primary human adipocytes. L. Zhao, J-H. Ha, I. Kang, M. Okla and S. Chung. Univ. of Florida.

9:30 222.7 Gene-dietary fat interaction and bone mineral density in children: a twin study in China. T. Huang, W. Zhao, H. Liu and Y. Wang. Johns Hopkins Univ. and Jiaxing Maternity and Children Hlth. Care Hosp., China.

9:45 222.8 Gene and nutrient interaction in obesity: trans fatty acid intake and genetic risk score interaction in a multiethnic sample of children. M.M. Bohan Brown, M. Rodriguez-Cruz and J.R. Fernandez. Univ. of Alabama at Birmingham and Mexican Soc. Security Inst., Mexico City.

223. IRON, COPPER AND CHRONIC DISEASE

Minisymposium

(Sponsored by: Vitamins and Minerals RIS)


Chaired: J. sWain

CoChaired: C. palaCios

8:00 223.1 Weight, serum hepcidin, and iron status in pregnant African American women. L. Tussing-Humphreys, R. White-Traut and M.D. Hennessy. Univ. of Illinois at Chicago.

8:15 223.2 Placental expression of the heme scavenger receptor, LDL receptor-related protein 1, is associated with expression of placental heme exporter, feline leukemia virus C receptor 1. C. Cao, E. Cooper, E. Pressman, R. Guillet and K.O. O’Brien. Cornell Univ. and Univ. of Rochester Sch. of Med.

8:30 223.3 Improvement of the intestinal Caco-2 cell model for iron absorption studies by the introduction of liver (HepG2) cells. N.M. Scheers, A. Almgren and A-S. Sandberg. Chalmers Univ. of Technol., Sweden.

8:45 223.4 Plasma and liver lipids of iron-deficient rats with excessive dietary manganese. K. Yokoi, A. Konomi, I. Tachibana and Y. Uchida. Seitoku Univ. and Teikyo Heisei Univ., Japan.

9:00 223.5 Silencing of the Menkes copper-transporting ATPase (ATP7a) in intestinal epithelial cells impairs cell growth and cell cycle control. S. Gulec and J.F. Collins. Univ. of Florida.

9:15 223.6 The small molecule genistein increases hepcidin expression by activating Stat3 and bone morphogenic protein signaling. P.G. Fraenkel, A.W. Zhen, N.H. Nguyen, Y. Gibert, S. Motola, P. Buckett, M. Wessling-Resnick and E. Fraenkel. Beth Israel Deaconess Med. Ctr./Harvard Med. Sch., Deakin Sch. of Med., Australia, MIT and Harvard Sch. of Publ. Hlth.

9:30 223.7 Effects of the iron transporter inhibitor ferristatin II on serum iron and lipid metabolism. J. Kim, P. Buckett and M. Wessling-Resnick. Harvard Sch. of Publ. Hlth.

9:45 223.8 Status of selected iron-status biomarkers in juvenile end-stage renal disease in a Guatemalan context: comparative aspects by mode of dialysis. J. Casimiro, R. Lou-Meda, M. Olbert, G. Weiss, D.W. Swinkels, H. Tjalsma, N.W. Solomons and K. Schümann. Tech Univ. Munich, Hosp. Roosevelt, Guatemala City, MBR Optical Systs., Wuppertal, Germany, Med. Univ. of Innsbruck, Radboud Univ. Nijmegen Med. Ctr., Netherlands and CeSSIAM, Guatemala City.

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224. EFFECTS OF DIETARY BIOACTIVE COMPONENTS ON EXPERIMENTAL MODELS OF CHRONIC DISEASE RISK

Minisymposium

(Sponsored by: Dietary Bioactive Components RIS)


Chaired: K.r. Walsh

CoChaired: a. neilson

8:00 224.1 Dietary supplementation of ginseng prevents obese and metabolic syndromes in high fat diet-fed mice. X. Li, J. Luo, A.P. Velayuthan, R. McMillan, M. Hulver, W. Zhen, H. Alkhalidy and D. Liu. Virginia Tech.

8:15 224.2 Effects of garlic (Allium sativum) on indicators of diabetic nephropathy. M. Thomson, K. Al-Qattan, M.H. Mansour and M. Ali. Fac. of Sci., Kuwait Univ.

8:30 224.3 Quercetin encapsulated nanocarriers: effects on breast cancer cell growth, apoptosis, and uptake in vitro and bioavailability in vivo. M. Sun, S. Nie, X. Pan, Z. Fan and S. Wang. Texas Tech Univ.

8:45 224.4 Correlation network analysis in evaluating dietary milk polar lipids in a mouse model of diet-induced obesity. A.L. Zhou, R. Ward and M. Lefevre. Utah State Univ.

9:00 224.5 Epigallocatechin gallate-loaded nanoparticles decrease cholesterol content in THP-1 derived macrophages. J. Zhang, S. Nie and S. Wang. Texas Tech Univ.

9:15 224.6 Decaffeinated green tea extract and voluntary exercise alters the expression of genes related to lipid metabolism and mitochondrial biogenesis in liver and skeletal muscle in high fat-fed mice. S. Sae-tan, C.J. Rogers and J.D. Lambert. Penn State.

9:30 224.7 Artificial sweetener consumption differentially affects the gut microbiota-host metabolic interactions. T.E. Cowan, M. Palmnas, R. Reimer, K. Ardell, J.J. Yang, H. Vogel and J. Shearer. Univ. of Calgary, Canada.

9:45 224.8 Quercetin and green tea extract supplementation in high-fat diet-induced inflammation and glucose intolerance in mice. L. Cialdella-Kam, S. Ghosh, M.P. Meaney, A.M. Knab, R.A. Shanely and D.C. Nieman. Appalachian State Univ., Kannapolis and North Carolina Central Univ.

225. INTERVENTIONS FOR THE TREATMENT AND PREVENTION OF NUTRITION-RELATED DISEASES

Minisymposium



Chaired: p.m. Kris-etherton

CoChaired: C.W. Bales

8:00 225.1 Dose-response effect of marine-derived omega-3 fatty acids on erythrocyte membrane fatty acid content: double-blind randomized controlled trial. M.R. Flock, A.C. Skulas-Ray, W.S. Harris, J.A. Fleming and P.M. Kris-Etherton. Penn State, Univ. of South Dakota and OmegaQuant Analytics LLC, Sioux Falls.

8:15 225.2 Effects of vitamin C and vitamin D on mood and distress in acutely hospitalized patients. Y. Wang, X.J. Liu, L. Robitaille, S. Eintracht, E. MacNamara and L.J. Hoffer. McGill Univ. Fac. of Med. and Jewish Gen. Hosp., Montreal.

8:30 225.3 The uremic molecule p-cresol is lowered after supplementing the diet of chronic kidney disease patients with fiber. Y. Salmean and W.J. Dahl. Univ. of Florida.

8:45 225.4 Differential effects of whole and refined grains on abdominal adipose tissue depots in an exploratory subgroup analysis of the grain study. K. Harris, S. Lemieux, S. Jonnalagadda, S. West, J. Vanden Heuvel and P. Kris-Etherton. Penn State and General Mills, Minneapolis.

9:00 225.5 Dietary behavior modification, with or without exercise, improves risk factors for CVD over one year in overweight and obese lactating women. H.K. Brekke, F. Bertz, K.M. Rasmussen, I. Bosaeus, L. Ellegård and A. Winkvist. Sahlgrenska Acad., Univ. of Gothenburg, Sweden and Cornell Univ.

9:15 225.6 Effects of egg ingestion on endothelial function in adults with coronary artery disease: a randomized, controlled, crossover trial. D.L. Katz, Y. Ma, Y. Kavak and V. Njike. Yale Univ. Prevent. Res. Ctr.

9:30 225.7 Daily almond consumption (1.5 oz.) decreases non-HDL and remnant lipoproteins in mildly hypercholesterolemic individuals. C.E. Berryman, S.G. West, P.L. Bordi, J.A. Fleming and P.M. Kris-Etherton. Penn State.

9:45 225.8 Key markers associated with intestinal adaptation in pediatric short bowel syndrome. J.K. Naberhuis and K.A. Tappenden. Univ. of Illinois, Urbana.

226. OBESITY AND THE METABOLIC SYNDROME II

Minisymposium

(Sponsored by: Energy and Macronutrient Metabolism RIS)


Chaired: v.J. vieira-potter

CoChaired: e. evans

8:00 226.1 DUSP1 gene polymorphisms are associated with obesity-related metabolic complications and gene methylation levels in severely obese patients. F. Guénard, L. Bouchard, A. Tchernof, Y. Deshaies, F-S. Hould, S. Lebel, P. Marceau and M-C. Vohl. Laval Univ., CRCHUQ, Quebec, Univ. of Sherbrooke and Quebec Heart and Lung Inst.

8:15 226.2 Fat utilization impacts the negative relationship between insulin sensitivity and leucine. A. Thalacker-Mercer, K. Heimburger Ingram and W.T. Garvey. Cornell Univ., Kennesaw State Univ., Univ. of Alabama at Birmingham and Birmingham VA Med. Ctr.

8:30 226.3 Changing prevalence of overweight, obesity and metabolic syndrome criteria among college students. J.S. Morrell, R.A. Reilly and G.B. Carey. Univ. of New Hampshire.

8:45 226.4 Low-fat milk protects against postprandial vascular endothelial dysfunction in adults with metabolic syndrome. K.D. Ballard, E. Mah, Y. Guo, R. Pei, J.S. Volek and R.S. Bruno. Univ. of Connecticut and The Ohio State Univ.

9:00 226.5 High fat breakfasts affect antioxidant and oxidative biomarkers more in metabolic syndrome subjects compared with healthy controls. P. Lewandowski, G. van Egmond, A. Larsen, M. Bonham, S. McCoombe, A. Sinclair and D. Cameron-Smith. Deakin Univ., La Trobe Univ. and Monash Univ., Australia and Univ. of Auckland, New Zealand.

NUTRITION MONDAY

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9:15 226.6 Associations among body mass index, waist circumference, dietary factors and cardiometabolic risks in 10th grade students: The NEXT Generation Health Study. C.A. Pratt, R.J. Iannotti, K. Li, M. D’Elio, S. Olson, L. Lipsky, B. Simons-Morton and R. Fan. NHLBI and NICHD, NIH and The CDM Group Inc., Bethesda.

9:30 226.7 Carbohydrate restriction reduces dyslipidemias associated with atherogenic lipoprotein profiles in Emirati men and women with metabolic syndrome. T. Al-Sarraj, J.S. Volek, H. Saadi and M.L. Fernandez. Tawam Hosp., United Arab Emirates, Univ. of Connecticut and United Arab Emirates Univ.

9:45 226.8 Sugar-sweetened soda intake and obesity among Korean adults: the Korea National Health and Nutrition Examination Survey 2007-2009. H-S.H. Lee, H-J. Lee, M.J. Stampfer, W.C. Willett, Y. Lee, C. Kim and E. Cho. Brigham and Women’s Hosp., Harvard Med. Sch., Korea Hlth. Indust. Develop. Inst., Osan and Harvard Sch. of Publ. Hlth.

227. DIET AND INFLAMMATION: NEW CONCEPTS ON THE IMPACT OF NUTRIENTS ON IMMUNE MODULATION

Symposium

(Supported by an educational grant from Abbott Nutrition, Raymond Tseng, DDS, PhD and Shaklee)

(Sponsored by: Nutrition Immunology RIS)

mon. 10:30 am—Boston Convention & exhiBition Center, Ballroom east

Chaired: p. a. sheriDan

CoChaired: s.r. shaiKh,


10:30 Interaction of nutrition with immune function, disease occurrence and severity. W. Fawzi. Harvard Univ.

11:00 Microbial diets: exploring microbial cooperation and competition in the human gut. A. Goodman. Yale Univ.

11:30 A unique role for dietary selenium influencing inflammation. K. S. Prabhu. Penn State.

12:00 The impact of diet on stress and inflammation. J. Kiecolt-Glaser. The Ohio State Univ.

228. HEALTH, NUTRITION AND COST OUTCOMES OF HUMAN MILK FEEDING FOR VERY LOW BIRTH WEIGHT INFANTS

Symposium

(Supported by an educational grant from Medela, Inc.)

(Sponsored by: Lactation RIS)

mon. 10:30 am—Boston Convention & exhiBition Center, 157aBC

Chaired: p. meier

CoChaired: l. BoDe


10:30 The cost-effectiveness of human milk feedings as a strategy to reduce the risk of prematurity-specific morbidities in VLBW infants. T. J. Johnson. Rush Univ. Med. Ctr.

11:00 Clinical, technical and operational challenges in promoting and advocating human milk for preterm infants. J. H. Kim. UCSD.

11:30 Manipulation of the intestinal microbiome in the newborn infant. J. Neu. Univ. of Florida.

12:00 Enterally administered bovine colostral extract modulates intestinal barrier function and immune gene expression in parenterally-fed neonatal piglets. S. Donovan. Univ. of Illinois, Urbana.

229. CLINICAL NUTRITION UPDATE 2013: A NUTRITION PERSPECTIVE FROM THE CROSSROADS OF HOSPITAL OUTCOMES AND MEDICARE POLICY

Symposium



Chaired: e. saltzman

CoChaired: m.a. Johnson anD C.W. Bales

Clinical Nutrition

10:30 Medicare and healthcare-related complications: an overview. R. Dupee. Tufts Med. Ctr.

10:54 The role for nutrition in prevention and treatment of infectious and non-infectious hospital acquired conditions: pneumonia, C. difficile colitis and decubitus ulcers. S. N. Meydani. USDA at Tufts Univ.

11:18 The role for nutrition in prevention and treatment of infectious and non-infectious hospital acquired conditions: Pneumonia, C. Difficile, colitis and Decubitus ulcers. D. S. Seres. Columbia Univ.

11:42 Growth failure due to malnutrition in hospitalized children. W. A. Walker. Massachusetts Gen. Hosp., Harvard Med. Sch.

12:06 A new approach to diagnosis and coding of malnutrition: preliminary experience. G. J Jensen. Penn State.

230. DIETARY ASSESSMENT TOOLS AND APPLICATIONS

Minisymposium

(Sponsored by: Nutritional Epidemiology RIS)


Chaired: J. mCDermiD

CoChaired: r. Bailey

10:30 230.1 Photo-assisted 24-hour dietary recalls in adults with intellectual and developmental disabilities. L.T. Ptomey, S. Herrmann, J. Lee, D. Sullivan and J. Donnelly. Univ. of Kansas Med. Ctr., Kansas City and Lawrence.

10:45 230.2 Usability of mobile phone food records to assess dietary intake in adolescents. S.L. Casperson, J. Reineke, J. Sieling, J. Moon and J. Roemmich. USDA, Grand Forks and MEI Res. Ltd., St. Louis Park, MN.

11:00 230.3 Identifying plausible energy intake for children who attend child care. C.L. Martin, D.P. Hales, A.P. Vaughn and D.S. Ward. Univ. of North Carolina at Chapel Hill.

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11:15 230.4 Validity of the National Cancer Institute’s automated self-administered 24-hour recall: results of a feeding study. S.I. Kirkpatrick, F.E. Thompson, A.F. Subar, D. Douglass, T.P. Zimmerman, L.L. Kahle, S.M. George and N. Potischman. NCI, NIH and Westat and Info. Mgmt. Svc. Inc., Rockville, MD.

11:30 230.5 Evaluation of the Healthy Eating Index-2010. P.M. Guenther, S.I. Kirkpatrick, S.M. Krebs-Smith, J. Reedy, D.W. Buckman, K.W. Dodd and R.J. Carroll. USDA, Alexandria, VA, NCI, NIH, Info. Mgmt. Svcs. Inc., Rockville and Texas A&M Univ.

11:45 230.6 Development and validation of the U.S. Healthy Food Diversity Index: a novel measure of dietary variety, quality, and proportionality. M. Vadiveloo, T. Mijanovich, L.B. Dixon and N. Parekh. NYU Sch. of Culture, Educ. and Human Develop.

12:00 230.7 Skin total carotenoids predict plasma carotenoid levels during a 28-week experimental feeding study with varying levels of vegetables and fruit. L. Jahns, L. Whigham, L. Johnson, S.T. Mayne, B. Cartmel, I. Ermakov and W. Gellermann. USDA, Grand Fork., Yale Sch. of Publ. Hlth. and Univ. of Utah.

12:15 230.8 Employing the water balance questionnaire for the evaluation of water balance in adults, pregnant women and elderly. M. Kapsokefalou, O. Malisova, A. Zampelas, V. Bountziouka and D. Panagiotakos. Agr. Univ. of Athens and Harokopion Univ., Greece.

231. BEHAVIORAL SCIENCE AND EATING BEHAVIOR CHANGE

Minisymposium

(Sponsored by: Nutrition Education RIS)


Chaired: s. JonnalaGaDDa

10:30 231.1 Snacks are not food: low-income mothers’ definitions and feeding practices around child snacking. J.O. Fisher, G. Wright, A. Herman, K. Malhotra, E.L. Serrano, G.D. Foster and R.C. Whitaker. Temple Univ. and Virginia Tech.

10:45 231.2 Dietary fiber content and benefit labeling did not increase high-fiber bread sales. M.E. Camire, H.E. Morin and M. Teisl. Univ. of Maine.

11:00 231.3 Relationship of cravings with weight loss and hunger: results from a 6 month worksite weight loss intervention. P.J. Batra, S.K. Das, T. Salinardi, L. Robinson, E. Saltzman, T. Scott, A. Pittas and S. Roberts. Tufts Univ. and Boston Children’s Hosp.

11:15 231.4 Drill sergeants’ two contrasting approaches to “soldierization” and instilling healthy eating behaviors in soldiers. C.E. Blake, T.N. Rosemond, T.M. Torres-McGehee, E.A. Frongillo, M.P. Burke, A. Lenkerd, D.M. Minton, L.T.C.S. Cable and S.H. Glover. Univ. of South Carolina and Army Init. Mil. Trng. Ctr. of Excellence, Fort Eustis, VA.

11:30 231.5 Stress is associated with poor dietary quality in low-income women. J.E. Arsenault, M.K. Muth, S.C. Cates, A. Anater, J. Blitstein, S. Karns, K. Wohlgenant and M. Council. RTI Intl., Research Triangle Park.

11:45 231.6 Teaching medical students how to walk the walk: will improving student dietary habits change patient counseling perceptions? D. Kay, L. Abu-Shamat, B. Leong, D. Monlezun, L. Sarris and T. Harlan. Tulane Univ.

12:00 231.7 Exploring underlying reasons of eating patterns among a low-income adult population in Lake County, Indiana. Y. Zhao, S.S. Liu, Ó.M. McCarthy and M.A. McCrory. Purdue Univ.

12:15 231.8 The role of awareness and medication on health behaviors among individuals with hypertension. H. Kim and J. Kim. Univ. of Illinois at Urbana Champaign and East Carolina Univ.

232. HEALTH PROMOTION AND DISPARITIES IN DIVERSE COMMUNITIES

Minisymposium

(Sponsored by: Community and Public Health Nutrition RIS)


Chaired: C, BlaKe

CoChaired: C. araGon

10:30 232.1 Sources of dietary guidance-based food groups and empty calories among the U.S. population in relation to income and race/ethnicity. S.I. Kirkpatrick, J. Reedy and S.M. Krebs-Smith. NCI, NIH.

10:45 232.2 Predictors of sugar-sweetened beverage consumption classification among urban low income pre-school children. D.R. Glenn, K. Lora and D. Wakefield. Univ. of Connecticut Hlth. Ctr., East Hartford and Univ. of Oklahoma, Oklahoma City.

11:00 232.3 Parental perceptions of healthy beverage alternatives to sugar-sweetened beverages. J.A. Welsh, S.K. Healy and M.B. Vos. Emory Univ. and Children’s Healthcare of Atlanta.

11:15 232.4 Parental recognition and perception of commercially available foods and beverages containing non-nutritive sweeteners. A.C. Sylvetsky, M.J. Greenberg and K.I. Rother. NIDDK, NIH and Emory Univ.

11:30 232.5 Perceptions surrounding food preferences and avoidances in pregnant and lactating women in the Western Highlands of Guatemala. M. del Rosario García, M. Vossenaar, M.J.L. Bonorden and N.W. Solomons. CeSSIAM, Guatemala City and Hormel Foods Corp.Austin, MN.

11:45 232.6 Using qualitative data to contrast the socio-ecological conditions of low-income pregnant and postpartum women. M. Graham, C.M. Olson, K. Paul and J. Niederdeppe. Cornell Univ. and Nestle Nutr., Chatham, NJ.

12:00 232.7 Strategies to improve the dietary quality of Supplemental Nutrition Assistance Program beneficiaries: an assessment of stakeholder opinions. C.W. Leung, E.E. Hoffnagle, S.J. Blumenthal, H. Lofink, H.H. Jensen, S.B. Foerster, L.W.Y. Cheung, M. Nestle and W.C. Willett. UCSF, Ctr. for the Study of the Presidency and Congress, Iowa State Univ., Harvard Sch. of Publ. Hlth. and NYU.

12:15 232.8 Using community readiness assessment to inform environmental intervention development in the Children’s Healthy Living Program in remote underserved minority populations of the Pacific. M.K. Fialkowski, B. DeBaryshe, R. Areta, T. Belyeu-Camacho, A. Bersamin, G. Rojas, A. Vargo, C. Nigg, R. Leon Guerrero, B. Luick and R. Novotny. Univ. of Hawaii at Manoa, American Samoa Community Col., Northern Mariana Col., Northern Mariana Islands, Univ. of Alaska Fairbanks and Univ. of Guam.

NUTRITION MONDAY

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233. NUTRITION, PHYSICAL PERFORMANCE AND BONE HEALTH

Minisymposium

(Sponsored by: Aging and Chronic Disease RIS)


Chaired: D. houston

CoChaired: s. sahni

10:30 233.1 Intake of antioxidants and subsequent decline in physical function. B. Bartali, T. Curto, N. Maserejian and A. Araujo. New England Res. Insts., Watertown.

10:45 233.2 Intakes of total and plant protein are associated with greater muscle strength: the Framingham Osteoporosis Study. R.R. McLean, M.T. Hannan, D.P. Kiel, V. Casey, K.M. Mangano and S. Sahni. Inst. for Aging Res., Hebrew SeniorLife and Harvard Med. Sch.

11:00 233.3 The associations between serum antioxidant concentrations and bone mineral density in women aged 50 and over: an analysis of NHANES 2005-6. M.S. Hamidi and A.M-W. Cheung. Univ. Hlth. Nework, Toronto.

11:15 233.4 Longitudinal changes in bone turnover markers following Roux-en-Y gastric bypass surgery. T.S. Rogers, P.J. Havel, B.M. Wolfe, J. Blankenship, K.L. Stanhope, M.D. Van Loan and M.M. Swarbrick. Univ. of California, Davis, Oregon Hlth. & Sci. Univ. and USDA, Davis.

11:30 233.5 Calcium and vitamin D supplements do not prevent loss of bone mineral density in women undergoing therapy for breast cancer. M. Datta and G.G. Schwartz. Wake Forest Sch. of Med.

11:45 233.6 Calcium kinetics during bed rest with artificial gravity and exercise countermeasures. S.M. Smith, C. Castaneda Sceppa, K.O. O’Brien, S.A. Abrams, P. Gillman, S.R. Zwart and M.E. Wastney. NASA Johnson Space Ctr., Northeastern Univ., Tufts Univ., Boston, Cornell Univ., Baylor Col. of Med., EASI/NASA, USRA/NASA and Metabolic Modeling, West Lafayette, IN.

12:00 233.7 Persistent effects of a soy diet in early development on bone in female rats. J. Zhang, O. Lazarenko, T. Badger, M. Ronis and J-R. Chen. Arkansas Children’s Nutr. Ctr. and Univ. of Arkansas for Med. Sci.

12:15 233.8 Blueberry and blackcurrant consumption increases bone mineral density and content in high fat diet-induced obese male mice. S.G. Lee, T. Vance, D.Y. Soung, B. Kim, J. Lee, S.I. Koo, M.H. Drissi and O.K. Chun. Univ. of Connecticut and Univ. of Connecticut Hlth. Ctr.

234. ZINC AND SELENIUM

Minisymposium



Chaired: a. GriDer

CoChaired: s. henniGar

10:30 234.1 Zinc supplementation normalizes gene expression and enhances neurogenesis in a rat model of traumatic brain injury. E.C. Cope and C.W. Levenson. Florida State Univ. Col. of Med.

10:45 234.2 Supplementation with zinc affects serum microRNA levels in early pubertal females. A. Grider, R. Lewis, E. Laing and K. Wickwire. Univ. of Georgia.

11:00 234.3 TNFa redistributes ZnT2 to accumulate zinc in lysosomes and activate autophagic cell death in mammary epithelial cells. S.R. Hennigar, M.C. Lanz and S.L. Kelleher. Penn State.

11:15 234.4 Identification of selenoprotein P (Sepp1) binding site on mouse apolipoprotein E receptor-2. S. Kurokawa, F.P. Bellinger and M.J. Berry. Univ. of Hawaii.

11:30 234.5 Effects of high fat, selenium-deficient, and high-selenium diets on diabetes biomarkers in wildtype and glutathione peroxidase-1 null mice. R.A. Sunde and C-L.E. Yen. Univ. of Wisconsin-Madison.

11:45 234.6 Effect of high dietary Se intake and GPX1 overproduction on mouse susceptibility to gestational diabetes. L. Sun and X.G. Lei. Cornell Univ.

12:00 234.7 Spatial and temporal expression of histone H3 lysine 9 trimethylation foci by methylseleninic acid treatment. J.J. Rouse and W-H. Cheng. Univ. of Maryland College Park.

12:15 234.8 Modulating epigenetic changes during HIV infection via the selenium-mediated inhibition of KAT3B activity in macrophages. V. Narayan, R.C. Kodihalli and K.S. Prabhu. Penn State and MIT.

235. DIET AND CANCER: ANIMAL STUDIES

Minisymposium

(Sponsored by: Diet and Cancer RIS)


Chaired: B. linDshielD

CoChaired: h. Chen

10:30 235.1 The interaction of tomato powder and soy germ on prostate carcinogenesis in the TRAMP model. K.E. Zuniga, J.W. Smith, S.K. Clinton and J.W. Erdman. Univ. of Illinois at Urbana Champaign and The Ohio State Univ.

10:45 235.2 Maternal high fat diet promotion of mammary tumor risk in adult progeny is associated with early expansion of mammary cancer stem-like cells and increased maternal oxidative environment. M.T.E. Montales, S. Melnyk and R.C.M. Simmen. Univ. of Arkansas for Med. Sci.

11:00 235.3 Effects of quercetin in a mouse model of colitis-associated colon cancer. J.L. McClellan, J.L. Steiner, R.T. Enos and E.A. Murphy. Univ. of South Carolina.

11:15 235.4 Linking inflammation to tumorigenesis in a mouse model of high-fat-diet-enhanced colon cancer. E.A. Murphy, S.D. Day, R.T. Enos, J.L. McClellan, J.L. Steiner and K.T. Velazquez. Univ. of South Carolina.

11:30 235.5 Obesity acclerates pancreatic tumor growth and increases the accummulation of myeloid derived suppressor cells. S. Collins, W.J. Turbitt and C.J. Rogers. Penn State, State College and Hershey.

11:45 235.6 Lycopene metabolite, apo-10’-lycopenoic acid, inhibits diet-induced obesity-promoted liver carcinogenesis via the upregulation of SIRT1 signaling and the decrease in liver inflammation. B.C. Ip, K-Q. Hu, C. Liu, D.E. Smith, L.M. Ausman and X-D. Wang. USDA at Tufts Univ.

12:00 235.7 Cruciferous and apiaceous vegetable intake protect colon and prostate against PhIP genotoxicity in Wistar rats. J.K. Kim, M. Warnert, D.D. Gallaher and S.P. Trudo. Univ. of Minnesota, St. Paul.

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12:15 235.8 Anticancer effects of garcinol in pancreatic cancer transgenic mouse model. N. Saadat, S. Akhtar, A. Gill, N. Razalli, S. Vemuri, A. Goja, A. Geamanu, D. David and S. Gupta. Wayne State Univ. and Sinai-Grace Hosp., Detroit.

236. OBESITY: PHYSICAL ACTIVITY

Minisymposium

(Sponsored by: Obesity RIS)


Chaired: J.o. hill

CoChaired: D. thomas

10:30 236.1 Predicting lower extremity pain based on foot morphology and computerized gait analysis in obese children. W.W. Wong, J.A. Ross, S.H. Abrams, S.E. Barlow and W.J. Klish. Baylor Col. of Med.

10:45 236.2 Weight change, calorie intake, and macronutrient profiles for 6 and 12 month diet and exercise interventions in participants with pre-diabetes: Does duration of treatment make a difference? E.O. Granville, K.N. Starr, A. Ratliff, L.A. Connor, C.A. Slentz, L.A. Bateman, L.H. Willis, L. Piner, W.E. Kraus and C.W. Bales. Duke Univ. Med. Ctr. and Durham VA Med. Ctr.

11:00 236.3 Effects of exercise during the menopausal transition on circulating inflammatory markers, including plasma zinc. L.R. Woodhouse, B. Burtt, J. Domek, M. Gustafson, N.L. Keim, C. Campbell and J. Peerson. USDA, Davis and Univ. of California, Davis.

11:15 236.4 Objectively measured physical activity in overweight and obese pregnant women can be predicted by self-efficacy and pre-pregnancy BMI. K.L. Kong, A. Welch, C. Campbell, A. Peterson and L. Lanningham-Foster. Iowa State Univ. and Johnson State Col., VT.

11:30 236.5 The interaction between physical activity and obesity gene variants in association with BMI: does the obesogenic environment matter? A.S. Richardson, K.E. North, M. Graff, K.L. Young, K.L. Mohlke, E.M. Lange, L.A. Lange, K.M. Harris and P. Gordon-Larsen. Univ. of North Carolina at Chapel Hill.

11:45 236.6 Physical activity policies at childcare centers and impact on children’s physical activity and screen-time behaviors. T.O. Erinosho, D.P. Hales, A.E. Vaughn, S. Mazzucca and D.S. Ward. Univ. of North Carolina at Chapel Hill.

12:00 236.7 Alternate day fasting when combined with endurance exercise reduces leptin but not adiponectin and resistin. S. Bhutani, M.C. Klempel, C.M. Kroeger and K.A. Varady. Univ. of Illinois at Chicago.

12:15 236.8 Closing the energy gap through passive energy expenditure. J.N. Roemmich. USDA, Grand Forks.

237. REGULATION OF FOOD INTAKE

Minisymposium

(Sponsored by: Energy & Macronutrient Metabolism RIS)

(Cosponsored by: Obesity RIS)


Chaired: J. hollis

CoChaired: h. leiDy

10:30 237.1 Environmental enrichment and cafeteria diet synergistically modify the response to chronic variable stress in rats. N. Zeeni, M. Bassil, S. Al Nafeesi, M. Ibrahim, T. Zein, G. Fromentin, C. Chaumontet and C. Daher. Sch. of Arts and Sci., Lebanese American Univ. and AgroParisTech, France.

10:45 237.2 Reduced responsiveness to intraintestinal nutrients in obese-prone rats fed high-fat diet. F.A. Duca and M. Covasa. INRA, UMR 1319 Micalis, Jouy-en-Josas and Col. of Osteo. Med., Western Univ. of Hlth. Sci.

11:00 237.3 Reshaping breakfast: the smaller the cereal flake, the greater the intake. B.J. Rolls, L.S. Roe and J.S. Meengs. Penn State.

11:15 237.4 The satiety response to a standard lunch in habitual breakfast eaters and skippers. S.M. Forester, M. Witbracht, W. Horn, K. Laugero and N.L. Keim. Univ. of California, Davis and USDA, Davis.

11:30 237.5 Mealtime beverage and food intake to satiation interacts with meal advancement in healthy young men and women. D. El Khoury , S. Panahi, B.L. Luhovyy, H.D. Goff and G.H. Anderson. Univ. of Toronto, Mount Saint Vincent Univ., Halifax and Univ. of Guelph, Canada.

11:45 237.6 Long-term feeding of dietary slow release glucose reduces daily caloric food intake in vivo. L. Yan, R. Phillips, T. Powley, K. Kinzig, C.Y. Kim and B. Hamaker. Purdue Univ.

12:00 237.7 Effect of soluble fiber dextrin on postprandial appetite and subsequent food intake in healthy adults. C. Hutchinson and J. Hollis. Iowa State Univ.

12:15 237.8 Effects of pulse physical form and digestive enzyme availability on postprandial glucose and appetite responses. K. Osei-Boadi, B.S. Wonnell, W.W. Campbell, G.P. McCabe and M.A. McCrory. Purdue Univ.

238. G.A. LEVEILLE AWARD LECTURE

Keynote Lecture

(Sponsored by: Institute of Food Technologists and American Society for Nutrition)

mon. 1:45 pm—Boston Convention & exhiBition Center, Ballroom east

Speaker: S. J. Schwartz. The Ohio State Univ.

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239. OBESITY-RELATED INFLAMMATION AND VITAMIN D AND CALCIUM METABOLISM

Symposium

(Sponsored by: Vitamin and Minerals RIS)

mon. 3:00 pm—Boston Convention & exhiBition Center, Ballroom east

Chaired: C. palaCios

CoChaired: C.J. CiFelli


3:00 Understanding the complex interaction between obesity, inflammation and vitamin D status. M. Holick. Boston Univ. Med. Ctr.

3:30 Vitamin D status and metabolic syndrome in epidemiological studies. V. Ganji. Georgia State Univ.

4:00 Effects of supplementation with vitamin D and calcium on adiposity and inflammatory markers. D. Teegarden. Purdue Univ.

4:30 Mechanisms underlying the effect of vitamin D on metabolic diseases. M. T. Cantorna. Penn State.

240. IMPACT OF NEW GENERATION PARENTERAL LIPID EMULSIONS IN PEDIATRIC NUTRITION

Symposium

(Supported by an educational grant from Fresenius Kabi USA)


mon. 3:00 pm—Boston Convention & exhiBition Center, 157aBC

Chaired: s. aBrams


3:00 Introduction and overview. Current lipid emulsions and their use in pediatric nutrition. S. Abrams. USDA, Baylor Col. of Med.

3:30 What is the evidence for lipid lowering strategies and omega-3 lipids in treatment of pediatric liver disease? M. Puder. Children’s Hosp. Boston, Harvard.

4:00 Impact of new generation lipid emulsions in animal models of PNALD. D. Burrin. USDA, Baylor Col. of Med.

4:30 Quality of evidence and perspectives on evaluation and use of new lipid emulsions. P. W. Wales. The Hosp. for Sick Children, Univ. of Toronto.

241. FOOD AND NUTRITION BOARD UPDATE: WHAT DO SNAP ALLOTMENTS, PHYSICAL FITNESS, AND OBESITY PREVENTION HAVE IN COMMON?

Symposium

(Sponsored by: The Food and Nutrition Board)


Chaired: l. meyers

CoChaired: s. p. murphy

Education Track/Professional Development

Science Policy

3:00 Welcome. L. D. Meyers. Inst. of Med., Food and Nutr. Board.

3:05 The Food and Nutrition Board: What’s new? What’s next? S. P. Murphy. Univ. of Hawaii Cancer Ctr., Food and Nutr. Board.

3:15 SNAP benefits: Can an adequate benefit be defined? Examining the evidence. J. Caswell. Univ. of Massachusetts Amherst.

3:45 Physical fitness: How should it be measured? R. Pate. Univ. of South Carolina.

4:15 Obesity prevention: Where do we stand? S. K. Kumanyika. Univ. of Pennsylvania Perelman Sch. of Med.

4:45 Open discussion and closing remarks.

242. RESEARCH WITH DIETARY SUPPLEMENTS AND BIOACTIVE COMPONENTS

Minisymposium

(Sponsored by: Nutritional Epidemiology RIS)


Chaired: r. Bailey

CoChaired: n. ahluWalia

3:00 242.1 The response to vitamin E supplementation. K.A. Guertin, A.H. Agler, J. LaBarre, R.S. Parker, A.R. Kristal, K.B. Arnold, J. Hartline, P.J. Goodman, C.M. Tangen, L.M. Minasian, S.M. Lippman, E. Klein and P.A. Cassano. Cornell Univ., Fred Hutchinson Cancer Res. Ctr., SWOG Stat. Ctr., Seattle, NCI, NIH, UCSD and Cleveland Clin.

3:15 242.2 Longitudinal and secular trends in dietary supplement use: Nurses’ Health Study and Health Professionals Follow-up Study, 1986-2006. H.J. Kim, E. Giovannucci, W.C. Willett and E. Cho. Brigham and Women’s Hosp. and Harvard Med. Sch.

3:30 242.3 Progress in the development of federal resources to assess dietary supplement exposures. J. Dwyer, K.W. Andrews, R.L. Bailey, J.M. Betz, V.L. Burt, R.B. Costello, N.J. Emenaker, J.J. Gahche, C.J. Hardy, P.R. Pehrsson, J.M. Roseland and L.G. Saldanha. ODS and NCI, NIH, USDA, Beltsville, NCHS, CDC, Hyattsville and FDA, College Park.

3:45 242.4 Dietary supplement use among older adults in the United States, NHANES 2007-2010. J.J. Gahche, R. Bailey, V. Burt and J. Dwyer. NCHS, Ctrs. for Dis. Control and Prevent., Hyattlville and ODS, NIH.

Visit The ExhibitsSunday–Tuesday9:00 AM–4:00 PM

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4:00 242.5 Why children use dietary supplements. R.L. Bailey, J.J. Gahche, P.R. Thomas and J.T. Dwyer. ODS, NIH and Natl. Ctr. for Hlth. Stats., CDC, Hyattsville.

4:15 242.6 Parent and child use of dietary supplements are associated. J.T. Dwyer, P.F. Jacques, G.T. Rogers, C. Sempos and R.L. Bailey. ODS, NIH, USDA and Friedman Sch. of Nutr. Sci. and Policy, Tufts Univ.

4:30 242.7 Dietary supplement use is associated with positive mood states in U.S. Military and Coast Guard personnel. K.G. Austin, S.M. McGraw and H. Lieberman. U.S. Army Res. Inst. of Envrn. Med., Natick, MA.

4:45 242.8 Chemical analysis of omega-3 (n-3) fatty acid supplements for the Dietary Supplement Ingredient Database. K.W. Andrews, J.M. Roseland, A. Middleton, A. Solomon, J. Palachuvattil, P.T. Dang, J.M. Holden, P.R. Pehrsson, J.T. Dwyer, R.L. Bailey, J.M. Betz, R.B. Costello, L.G. Saldanha, C.J. Hardy, J.J. Gahche, N.J. Emenaker and L. Douglass. USDA, Beltsville, ODS, NIH, FDA, College Park, Natl. Ctr. for Hlth. Stats., CDC, Hyattsville, NCI, NIH and Consulting Statistician, Longmont, CO.

243. GLOBAL NUTRITION: PUBLIC HEALTH

Minisymposium

(Sponsored by: Global Nutrition Council (GNC))


Chaired: r. pérez-esCamilla

CoChaired: a. hromi-FieDler

3:00 243.1 Effects of water-based hand sanitizers and micronutrient powders along with nutrition and hygiene education to prevent infections and linear growth faltering among low birth weight infants in Bangladesh. S. Shafique, C.S.B. Jalal, S.P. Jolly, H. Shikder, D.W. Sellen and S. Zlotkin. Univ. of Toronto and Hosp. for Sick Children, BRAC, Dhaka, Bangladesh and Micronutr. Initiative, Ottawa.

3:15 243.2 Environmental hygiene, food safety and growth in less than five-year-old children in Zimbabwe and Ethiopia. F.M. Ngure, J.H. Humphrey, P. Menon and R. Stoltzfus. Cornell Univ., Johns Hopkins Bloomberg Sch. of Publ. Hlth., Zvitambo Proj., Harare and Intl. Food Policy Res. Inst., New Delhi.

3:30 243.3 Understanding healthcare workers perceptions of iron and folic acid supplementation in Bihar, India. A. Wendt, M. Young and R. Marorell. Emory Univ.

3:45 243.4 A focused ethnographic tool provides insights into socially normative infant and young child feeding practices in the context of a behavior change communications intervention in rural Bangladesh. A.A. Zongrone, M.I. Bhuiyan, K. Singh, T. Roopnaraine and P. Menon. Cornell Univ., Intl. Food Policy Res. Inst., Washington, DC and Independent Researcher, Lusaka, Zambia.

4:00 243.5 Behavior change counseling by frontline health workers and a mass media campaign improved complementary feeding practices more than mass media alone in rural Bangladesh. K.K. Saha, R. Rawat, A. Khaled, T. Sanghvi, K. Afsana, R. Haque, S. Siraj, M.T. Ruel and P. Menon. Intl. Food Policy Res. Inst., Washington, DC and FHI360 and BRAC, Dhaka, Bangladesh.

4:15 243.6 Household food insecurity and obesity risk in an urban slum in Brazil. K. Peterson, G. de Sousa Ribeiro, M. Galvão dos Reis, I. A.D. Paploski, A. Ko, R. Salles-Costa and R. Pérez-Escamilla. Yale Sch. of Publ. Hlth., Fed. Univ. of Bahia, Brazil, Oswaldo Cruz Fndn., Salvador, Brazil and Fed.Univ. of Rio de Janeiro.

4:30 243.7 Do babies eat what mothers eat? The relationship between maternal and child dietary diversity in Bangladesh, Vietnam and Ethiopia. P.H. Nguyen, R. Avula, K.K. Saha, D. Ali, L.M. Tran, E.A. Frongillo, R. Rawat, M.T. Ruel and P. Menon. Intl. Food Policy Res. Inst., Washington, DC and Univ. of South Carolina.

4:45 243.8 Hemoglobin at age 6 weeks and subsequent mortality among HIV-exposed infants. R.C. Carter, R. Kupka, K. Manji, S. Aboud, J. Okuma, R. Kisenge, W. Fawzi and C. Duggan. Boston Children’s Hosp., UNICEF Reg. Ofc. for West and Central Africa, Dakar, Senegal, Harvard Sch. of Publ. Hlth. And Muhimbili Univ. of Hlth. and Allied Sci., Tanzania.

244. ANIMAL RESEARCH MODELS IN NUTRITION AND MUSCULOSKELETAL DEVELOPMENT

Minisymposium

(Sponsored by: Experimental Animal Nutrition RIS)


Chaired: r.p. rhoaDs

CoChaired: K.l. ursChel

3:00 244.1 Differential response of anabolic signaling with high-fat feeding and aging in skeletal muscle after insulin stimulation. D.J. McDonald, E.P. Morris, P.H. Haran, R.A. Fielding and D.A. Rivas. Tufts Univ., Boston.

3:15 244.2 Amino acid metabolite infusion enhances muscle protein synthesis without altering degradation in neonates. S.M. Wheatley, S. El-Kadi, A. Suryawan, C. Boutry, R. Orellana, H. Nguyen, S. Davis and T. Davis. USDA, Houston and Abbott Nutr., Columbus.

3:30 244.3 Supplementation with a leucine pulse during continuous feeding stimulates translation initiation and suppresses protein degradation pathways in muscle of neonatal pigs. C. Boutry, S.W. El-Kadi, A. Suryawan, S.M. Wheatley, R.A. Orellana, H.V. Nguyen and T.A. Davis. USDA, Baylor Col. of Med. and Virginia Tech.

3:45 244.4 Insulin ameliorates skeletal muscle degradation during sepsis in neonatal pigs. R.A. Orellana, S.J. Koo, H.V. Nguyen, A. Suryawan, M. Desai, J.A. Coss-Bu and T.A. Davis. USDA, Baylor Col. of Med.

4:00 244.5 Neonatal dietary calcium alters mesenchymal stem cell differentiation potential in pigs. Y. Li, B. Seabolt and C. Stahl. North Carolina State Univ.

4:15 244.6 The role of C-3 a epimer of 25-hydroxyvitamin D on maintenance of bone mineral density. C.E. Bianchini, P. Lavery, S. Agellon and H.A. Weiler. Sch. of Dietetics and Human Nutr., McGill Univ.

4:30 244.7 Maternal high fat feeding results in higher fat mass and bone mineral content in weanling but not 3-month-old female offspring. L.M. Castelli, P.M. Miotto, R.E.K. MacPherson, B.D. Johnston, P.J. LeBlanc, S.J. Peters, B.D. Roy and W.E. Ward. Brock Univ., ON.

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4:45 244.8 Maternal high fat diet results in altered body composition in first generation male offspring at weaning but not adulthood. P.M. Miotto, L.M. Castelli, R.E. MacPherson, B.D. Johnston, P.J. LeBlanc, B.D. Roy, S.J. Peters and W.E. Ward. Brock Univ., Canada.

245. NUTRITIONAL ASSESSMENT AND STATUS IN OLDER POPULATIONS

Minisymposium

(Sponsored by: Aging and Chronic Disease RIS)


Chaired: C. tanGney

CoChaired: l. tinKer

3:00 245.1 The association between diet quality, BMI and health-related quality of life in the Geisinger Rural Aging Study. D.J. Ford, G.L. Jensen, R. Bailey, H. Smiciklas-Wright, P. Erickson, C. Wood, C. Still, D. Coffman and T.J. Hartman. Penn State, ODS, NIH, Rockville, Penn State Hershey and Geisinger Hlth. Syst., Danville, PA.

3:15 245.2 Association of diet quality score with periodontal disease in postmenopausal women: evidence from the Women’s Health Initiative Observational Study. L. Tinker, A. Millen, J. Wactawski-Wende, M. Pettinger, G. Sarto, M. Vitolins, R. Wallace, J. Freudenheim, M. LaMonte and R. Genco. Hutchinson Ctr., Seattle, Univ. at Buffalo, Univ. of Wisconsin-Madison, Wake Forest Univ., Univ. of Iowa and Univ. of Buffalo, Amherst.

3:30 245.3 The effects of behaviorally-based diet education and Tai Chi on dietary intake and resiliency in community dwelling older adults. A. Taetzsch, D. Lobuono, N. Beebe, J. Letendre, J. Bekke, M. Delmonico, F. Xu and I. Lofgren. Univ. of Rhode Island.

3:45 245.4 Predictors of serum 25(OH)D in elderly African-Americans in the Health, Aging, and Body Composition Study. J.G. Hansen, K. Hootman, W. Tang, P.M. Brannon, S. Kritchevsky, D. Houston, T. Harris, M. Garcia, Y. Liu, K. Lohman and P.A. Cassano. Cornell Univ., Wake Forest Sch. of Med., NIA, NIH and Weill Cornell Med. Col.

4:00 245.5 Micronutrient intakes vary by age group and ethnicity in older U.S. populations. J.K. Bird and V.L. Fulgoni III. DSM Nutr. Products, LLC, Delft and Nutr. Impact LLC, Battle Creek, MI.

4:15 245.6 25-Hydroxyvitamin D and adiposity in older black and white adults: the Health ABC Study. D.K. Houston, J.A. Tooze, D.B. Hausman, M.A. Johnson, J.A. Cauley, D.C. Bauer, F.A. Tylavsky, T.B. Harris and S.B. Kritchevsky. Wake Forest Sch. of Med., Univ. of Georgia, Univ. of Pittsburgh, UCSF, Univ. of Tennessee Hlth. Sci. Ctr., Memphis and NIA, NIH.

4:30 245.7 Quantitative measures of forearm skin color and self-reported sun exposure scores predict serum 25(OH)D concentrations in a young multi-ethnic population living in South Florida, U.S. S. Ajabshir, J.C. Exebio, G.G. Zarini, C. Podesta, J.A. Vaccaro and F.G. Huffman. Florida Intl. Univ.

4:45 245.8 Results from the self-administered gerocognitive examination are not associated with misreporters of energy intake among multiethnic older adults. R. Ettienne-Gittens, C.J. Boushey, A. Steffen, S. Murphy and L.R. Wilkens. Univ. of Hawaii Cancer Ctr. and Col. of Nursing, Univ. of Illinois at Chicago.

246. B VITAMINS AND ONE-CARBON METABOLISM

Minisymposium



Chaired: l.B. Bailey

CoChaired: a. Devlin

3:00 246.1 Formate metabolism is altered in riboflavin-deficient rats. L. MacMillan, S. Lamarre, E. Andrivon, C. Dickie, M.E. Brosnan and J.T. Brosnan. Mem. Univ. of Newfoundland and Univ. of Moncton, Canada.

3:15 246.2 Obesity affects short-term folic acid pharmacokinetics in women of childbearing age. V.R. da Silva, D.B. Hausman, G.P. Kauwell, R. Tackett, S. Rathbun and L.B. Bailey. Univ. of Georgia and Univ. of Florida.

3:30 246.3 In vivo effect of 1-amino D-proline, an anti-pyridoxine factor, on the metabolism of vitamin B6-dependent enzymes in moderately vitamin B6 deficient rats. S. Mayengbam, S. Raposo, M. Aliani and J. House. Univ. of Manitoba.

3:45 246.4 Intakes, sources and blood levels of folate in Canadian pregnant women in the post-fortification era. S. Masih, L. Plumptre, A. Ly, H. Berger, A.Y. Lausman, R. Croxford, D.L. O’Connor and Y-i. Kim. Univ. of Toronto, St. Michael’s Hosp. and The Hosp. for Sick Children, Toronto.

4:00 246.5 Plasma homocysteine is directly correlated with white matter hyperintensity and lateral ventricular volume, and inversely correlated with regional brain volumes in folic acid fortified, cognitively intact older adults. J.W. Miller, R. Green, X. Lin, B.M. Bettcher, R. Wilheim, C.A. Racine, K. Yaffe, B.L. Miller and J.H. Kramer. Rutgers Univ., Univ of California, Davis, Sacramento and UCSF.

4:15 246.6 Frequency and determinants of marginal vitamin B12 deficiency in childbearing-aged women of South Asian and European descent in Metro Vancouver. T.A.W. Quay, T.H. Schroder, A.M. Devlin, S.I. Barr and Y. Lamers. Univ. of British Columbia.

4:30 246.7 Choline affects placental vascular function and development in a dose response manner. X. Jiang, S. Jones, A. Ganti, B. Andrew, P. Brannon, M. Roberson and M. Caudill. Cornell Univ.

4:45 246.8 Transcobalamin I (TC I) deficiency, a common cause of falsely low serum cobalamin (Cbl), is usually genetic, and plasma corrinoid analogs are decreased: is “withholding” Cbl and its analogs from human cells and the microbiome the chief biological role for R. Carmel, J. Parker and Z. Kelman. New York Methodist Hosp., Brooklyn, Weill Cornell Med. Col. and NIST, Rockville, MD.

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247. MECHANISMS OF ACTION AND MOLECULAR TARGETS OF DIETARY BIOACTIVE COMPONENTS

Minisymposium

(Sponsored by: Dietary Bioactive Components RIS)


Chaired: z. e. Jouni

CoChaired: m. Ferruzzi

3:00 247.1 Spirulina platensis inhibits lipopolysaccharide-induced inflammation through the repression of histone deacetylases in RAW 264.7 macrophages. T.X. Pham, B. Kim and J. Lee. Univ. of Connecticut.

3:15 247.2 Novel sorghum brans containing bioactive compounds alter colon microbiota in response to a DSS-induced chronic inflammatory state. L.E. Ritchie, J.M. Sturino, M.A. Azcarate-Peril and N.D. Turner. Texas A&M Univ. and Univ. of North Carolina Sch. of Med.

3:30 247.3 Gallic acid modifies the expression of intestinal maltase-glucoamylase mRNA but not enzyme activity. M. Simsek, B.R. Hamaker, B.L. Nichols and R. Quezada-Calvillo. Purdue Univ., Autonomous Univ. of San Luis Potosi, Mexico and USDA, Baylor Col. of Med.

3:45 247.4 Maternal dietary docosahexaenoic acid supplementation prevents fetal growth restriction and pulmonary fibrosis caused by perinatal inflammation. M. Velten, R.D. Britt, K.M. Heyob, T.E. Tipple and L.K. Rogers. Univ. Med. Ctr. Bonn and Nationwide Children’s Hosp., Columbus, OH.

4:00 247.5 Rosemary extract regulates glucose and lipid metabolism by activating AMPK and PPAR pathways in HepG2 cells. Z. Tu, T. Moss-Pierce, P. Ford and A. Jiang. McCormick and Co. Inc., Hunt Valley, MD.

4:15 247.6 Ellagic acid inhibits hyperplastic conversion of human adipose-derived stem cells through histone deacetylase-dependent mechanisms. I. Kang, D.M. Kim, V. Gourninei, B. Zhao, N. Shay, L. Gu and S. Chung. Univ. of Florida and Oregon State Univ.

4:30 247.7 Early life exposure to soy isoflavones in combination with an adequate but not supplemental level of folic acid improves bone development of CD-1 mice by suppressing expression of neuropeptide Y. J. Kaludjerovic and W.E. Ward. Univ. of Toronto and Brock Univ., Canada.

4:45 247.8 Dietary wolfberry upregulates BCDO2 and enhances mitochondrial biogenesis in the retina of db/db type 2 diabetic mice. D. Lin, H. Ji and D.M. Medeiros. Kansas State Univ. and Univ. of Missouri-Kansas City.

248. DIET AND CANCER: MOLECULAR TARGETS

Minisymposium

(Sponsored by: Diet and Cancer RIS)


Chaired: J. Fenton

CoChaired: C. roGers

3:00 248.1 Global DNA hypomethylation in peripheral blood mononuclear cells as a biomarker of cancer risk. P. Guarini, S. Udali, P. Pattini, S. Moruzzi, D. Girelli, F. Pizzolo, N. Martinelli, O. Olivieri, S.W. Choi and S. Friso. Univ. of Verona and USDA at Tufts Univ.

3:15 248.2 Genome-wide transcriptome analysis of the effects of sulforphane on normal and prostate cancer cells. L.M. Beaver, A. Buchanan, E.I. Sokolowski, J.H. Chang, C.P. Wong, D.E. Williams, R.H. Dashwood and E. Ho. Oregon State Univ.

3:30 248.3 An epigenetic perspective on pharmacologic ascorbate in colon cancer. M.C. Kaiser, P. Rajendran, M.W. Dashwood, M.A. Levine, A. Michaels, B. Frei and R.H. Dashwood. Oregon State Univ. and NIDDK , NIH.

3:45 248.4 Genome-wide DNA methylation and gene expression profiles analysis show novel regulatory pathways in alcohol-related hepatocellular carcinoma. S. Udali, P. Guarini, A. Ruzzenente, A. Guglielmi, A. Ferrarini, P. Tononi, P. Pattini, S. Moruzzi, M. Delledonne, S.W. Choi and S. Friso. Univ. of Verona and USDA at Tufts Univ.

4:00 248.5 Pomegranate polyphenols suppress colorectal aberrant crypt foci and inflammation: possible role of miR126 in vitro and in vivo. N. Banerjee, H. Kim, S. Talcott and S.U. Mertens-Talcott. Texas A&M Univ.

4:15 248.6 Identification of colonic metabolites of 5-hydroxylnobiletin and their roles in colon cancer inhibition. J. Zheng, M. Song, N. Charoensinphon and H. Xiao. Univ. of Massachusetts Amherst.

4:30 248.7 Benzyl isothiocyanate enhances chemosensitivity and inhibits migration and invasion of head and neck squamous cell carcinoma. M.A. Wolf, O. Bailiff, W.E. Hardman and P.P. Claudio. Marshall Univ. and Marshall Univ. Sch. of Med.

4:45 248.8 Pomegranate polyphenolics reduce inflammation in intestinal colitis—potential involvement of the miR-145/p70s6K/HIF1a pathway. H. Kim, N. Banerjee, C. Pfent, S. Talcott and S. Mertens-Talcott. Texas A&M Univ.

249. PROTEIN INTAKE AND HEALTH IMPLICATIONS

Minisymposium

(Sponsored by: Energy & Macronutrient Metabolism RIS)


Chaired: J.i. Baum

CoChaired: B. B. rasmussen

3:00 249.1 Calcium homeostasis and bone metabolic responses to protein diets and energy restriction: a randomized control trial. J. Cao, S.M. Pasiakos, L.M. Margolis, L.D. Whigham, J.P. McClung, A.J. Young and G.F. Combs. USDA, Grand Forks and U.S. Army Res. Inst. of Envrn. Med., Natick, MA.

POSTER PRESENTERS: UPLOAD YOUR POSTER

Where: E-Poster Counter, Sun. – Tue. Hall A; Wed. Hall CDeadline: Tue., April 23, 5:00 pm; Wed., April 24, 3:00 pm

Uploaded posters will be available online to all registered attendees following the meeting at

www. experimentalbiology.org

NUTRITION MONDAY

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3:15 249.2 Associations between biomarker-calibrated protein intake and bone health in the Women’s Health Initiative. J.M. Beasley, J. Larson, A.Z. LaCroix, M.L. Neuhouser, L.F. Tinker, R. Jackson, Y. Huang, L. Snetselaar, C. Eaton and R.L. Prentice. Albert Einstein Col. of Med., Fred Hutchinson Cancer Res. Ctr., Univ. of Iowa and Brown Univ.

3:30 249.3 Effect of dietary protein on bone status in U.S. adults aged 50 years and older: NHANES 1999-2004. J.E. Kim, M. Zanovec, V.L. Fulgoni III and W.W. Campbell. Purdue Univ., LSU AgCtr., Nutr. Impact LLC, Battle Creek, MI.

3:45 249.4 The contribution of gastroenteropancreatic appetite hormones to protein-induced satiety. A. Astrup, A. Belza, C. Ritz, M.Q. Sørensen, J.J. Holst and J.F. Rehfeld. Univ. of Copenhagen, Frederiksberg and Copenhagen and Rigshospitalet, Copenhagen.

4:00 249.5 The effect of eggs on satiety in children and adolescents. A. Liu, R.S. Puyau, H. Han, W.D. Johnson, F.L. Greenway and N.V. Dhurandhar. Pennington Biomed. Res. Ctr., Baton Rouge.

4:15 249.6 Carbohydrate co-ingestion with protein delays dietary protein digestion and absorption but does not modulate postprandial muscle protein accretion. S.H. Gorissen, N.A. Burd, H.M. Hamer, A.P. Gijsen and L.J.C. van Loon. Maastricht Univ. and TI Food and Nutr., Wageningen, Netherlands.

4:30 249.7 Daily addition of a protein-rich breakfast for long-term improvements in energy intake regulation and body weight management in overweight and obese ‘breakfast skipping’ young people. H.J. Leidy, H.A. Hoertel, S.M. Douglas and R.S. Shafer. Univ. of Missouri-Columbia.

4:45 249.8 The use of an ad libitum higher-protein, low-glycemic index diet in overweight children: the Diogenes Study. A. Astrup, C.T. Damsgaard, A. Papadaki, S.M. Jensen, S-M. Dalskov, P. Hlavaty, W.H.M. Saris, J.A. Martinez, T. Handjieva-Darlenska, M. Rohr-Andersen, S. Stender, T.M. Larsen, C. Mølgaard and K.F. Michaelsen. Univ. of Copenhagen, Frederiksberg, Univ. of Crete, Endocrinol., Prague, Maastricht Univ., Netherlands, Univ. of Navarra, Spain, Med. Univ., Sofia, Bulgaria and Gentofte Hosp., Denmark.

Pathology250. ACVP SYMPOSIUM: INSIDE-OUT:

EXTRACELLULAR ROLES FOR HEAT SHOCK PROTEINS

Symposium

(Sponsored by: ASIP and the American College of Veterinary Pathologists)


Chaired: m. oGlesBee

CoChaired: t. laBranChe

Veterinary Pathology

8:30 Hsp70 and a novel axis of innate immunity in the virus-infected brain. M. Oglesbee. The Ohio State Univ.

9:15 Extracellular heat shock proteins: mechanisms and immune functions. S. Calderwood. Beth Israel Deaconess Med. Ctr.

10:00 Extracellular hsp72 is a DAMP released by stress. M. R. Fleshner. Univ. of Colorado Boulder.

10:45 Regulation of extraceullular alpha-synuclein oligomer formation by hsp70: implications for Parkinson’s disease therapeutics. P. McLean. Mayo Clin. Fndn.

251. ANGIOGENESIS IN PHYSIOLOGY AND PATHOLOGY

Symposium

(Supported by an educational grant from Organovo)


Chaired: p. D’amore

CoChaired: D. BielenBerG

Vascular Biology

8:30 Molecular controls of arteriogenesis. M. Simons. Dartmouth-Hitchcock Med. Ctr.

9:15 The role of epoxyeicosatrienoic acids in cancer metastasis and regeneration. D. Panigrahy. Boston Children’s Hosp.

9:55 251.1 Glutaredoxin overexpression inhibits angiogenesis in vivo through regulation of soluble VEGFR1. C.E. Murdoch, M.M. Shuler, R. Kikuchi, K. Walsh, R.A. Cohen and R. Matsui. Boston Univ.

10:10 New approaches to target blood vessel assembly in infantile hemangioma. J. Bischoff. Boston Children’s Hosp.

10:50 Development of the ocular vasculature. R. Lang. Cincinnati Children’s Hosp.

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70

252. EMERGING INFECTIONS

Symposium


Chaired: s.r. zaKi anD D. milner

Inflammation

8:30 Introductory comments. S. R. Zaki. Ctrs. for Dis. Control and Prevent.

8:45 Developing new therapeutics and vaccinces for the emerging Henipaviruses. K. Bossart. Boston Univ.

9:25 Lighting up morbillivirus pathogenesis: Is virus eradication a reality, a redundant concept or a risk? P. Duprex. Boston Univ.

10:05 Imaging immunity to infection in the living brain. D. McGavern. NINDS, NIH.

10:45 252.1 Interactions between Francisella tularensis and hepatocytes. C.A. Thomas and M. Furie. Stony Brook Univ.

253. LIVER PATHOBIOLOGY SYMPOSIUM: FLIRTIN’ WITH DISASTER: LIVER INJURY, INFLAMMATION AND THE FAST LANE TO HCC

Symposium

(Sponsored by: ASIP Liver Pathobiology Scientific Interest Group)


Chaired: a. roGers anD B. Gao

Liver Pathobiology

8:30 Introduction.8:35 Expression and regulation of tissue factor on hepatocytes:

Match in a dynamite factory? J. Luyendyk. Michigan State Univ.

9:10 Inflammation, liver stem cells and cancer: a key role of interleukin-22. B. Gao. NIAAA, NIH.

9:45 Regulators of liver development and regeneration. W. Goessling. Harvard Stem Cell Inst.

10:20 Grrl power: mechanisms of female resistance to HCC. A. Rogers. Univ. of North Carolina.

10:55 Tumor suppressors in liver cancer: stress begets cancer and emergent concepts for therapy. E. Knudsen. Univ. of Texas Southwestern.

254. PULMONARY INFLAMMATION AND INJURY

Minisymposium


Chaired: l. KoBziK

CoChaired: J. montGomery

Pulmonary Pathobiology

8:30 254.1 Role of Hedgehog in bleomycin-induced pulmonary fibrosis. B. Hu, J. Liu, Z. Wu, T. Liu, M.R. Ullenbruch and S.H. Phan. Univ. of Michigan.

8:46 254.2 Minocycline blocks allergen-induced eosinophilia and production of TH2 cytokines and IgE by interfering with the T cell receptor-NF-kB-GATA-3-interleukin (II)-4 axis in a murine asthma model without an effect on PARP. A.S. Naura, H. Kim, J. Ju, P.C. Rodriguez, J. Jordan, K. Pyakurel, A.F. Tarhuni, A.C. Ochoa and H.A. Boulares. LSU Hlth. Sci. Ctr., New Orleans and Univ. of Castilla-La Mancha, Spain.

9:02 254.3 Increased alveolar surface area in neonatal pups with acute lung injury. O.J. Mezu-Ndubuisi, N.M. Reddy and S.P. Reddy. Children’s Hosp. of Univ. of Illinois at Chicago.

9:18 254.4 Resolvin E1 promotes neutrophil apoptosis and accelerates resolution of acute pulmonary inflammation. J.G. Filep, P. Gjorstrup and D. El Kebir. Univ. of Montreal and Resolvyx Pharmaceuts., Boston.

9:34 254.5 Endothelial GATA6 deficiency promotes pulmonary arterial hypertension through ER stress-mediated CHOP upregulation. S. Lenna, I.M. Chrobak, A. Ghatnekar, R. van Deuren, T. Radstake, C. Feghali-Bostwick and M. Trojanowska. Boston Univ. Med. Ctr., Med. Univ. of South Carolina, Radboud Univ. Nijmegen Med. Ctr., Netherlands and Univ. of Pittsburgh.

9:50 254.6 Endothelial cells contribute to inflammation and fibrosis in bleomycin-induced lung injury. H.G. Leach, I. Chrobak and M. Trojanowska. Boston Univ. Sch. of Med.

10:06 254.7 Remote lung injury after experimental intestinal ischemia-reperfusion in horses. J.B. Montgomery, S. Singh Suri, L. Johnson, D. Wilson and B. Singh. Univ. of Saskatchewan.

10:22 254.8 Surfactant activity and mobilization in minced saline extracts of neonatal brain, heart, kidney, liver, and lung. D.R. Shanklin. Marine Biol. Lab., Woods Hole.

10:38 254.9 Fat embolism syndrome following bone fracture may be exacerbated by LPS. A. Molteni, L. Torres-Romero, E. Black, J. Friedrich, J.C. Tanner, A. Poisner and B. Herndon. Univ. of Missouri-Kansas City Sch. of Med. and Univ. of Kansas Med. Ctr.

10:54 254.10 Lysophosphatidylcholine-induced mitochondrial ROS formation and activation of AMPK promote macrophage chemotaxis and efferocytosis. S. Jiang, D.W. Park, H-B. Bae and J.W. Zmijewski. Univ. of Alabama at Birmingham and Chonnam Natl. Univ., South Korea.

11:10 254.11 Rage signaling influences diesel particulate matter-induced inflammation in primary alveolar macrophages. D.B. Barton, B.C. Bettridge, T.D. Earley, A.B. Robinson and P.R. Reynolds. Brigham Young Univ.

255. ASIP COTRAN EARLY CAREER INVESTIGATOR AWARD LECTURE

Lecture

(Supported from an educational grant from Elsevier)


Neuropathology

2:00 Introduction S. Gonias. UCSD.2:05 Endoplasmic reticulum stress in disease pathogenesis.

J. H. Lin. UCSD.

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MON

256. EPITHELIAL INTERCELLULAR JUNCTIONS AND BARRIER REGULATION

Minisymposium


Chaired: J. WasChKe

CoChaired: C.r. WeBer

2:00 256.1 Identification of unitary tight junction pore opening/closing events in MDCK monolayers. C.R. Weber, G.H. Liang, L. Shen, Y. Wang, D.J. Nelson, A.S. Yu and J.R. Turner. Univ. of Chicago and Univ. of Kansas Med. Ctr.

2:15 256.2 JAM-A –mediated regulation of epithelial barrier function is dependent on a complex with ZO-2, Afadin and PDZ-GEF1 that modulates Rap2c activity. A. Monteiro, R. Sumagin, C.R. Rankin, G. Leoni, D. Reiter, T. Stehle, T. Dermody, R.A. Hall, A. Nusrat and C.A. Parkos. Emory Univ., Univ. of Tübingen and Vanderbilt Univ.

2:30 256.3 Claudin-4 promotes epithelial repair and restoration of barrier function via interactions with the small GTPase Rap1. K. Sutherland, T. Bentley, M. LaFemina and J. Frank. UCSF and San Francisco VA Med. Ctr.

2:45 256.4 Developmental expression and transcriptional regulation of claudin-6 in the murine lung. F.R. Jimenez, J.B. Lewis, T.T. Wood and P.R. Reynolds. Brigham Young Univ.

3:00 256.5 Fundamental role for hifHIF-2-regulated creatine kinase pathway in epithelial apical junctional integrity. L.E. Glover, B. Saeedi, S. Ehrentraut, E. Campbell, C. Kelly, D. Kominsky and S. Colgan. Univ. of Colorado Denver, Aurora.

3:15 256.6 Pemphigus autoantibodies identify a desmoglein 3/p38MAPK adhesion complex regulating keratinocyte cohesion. V. Spindler, C. Dehner, V. Roetzer and J. Waschke. Ludwig Maximilians Univ., Munich.

3:30 256.7 Desmoglein 2 ectodomain regulates intestinal epithelial cell homeostasis. R. Kamekura, P. Nava-Dominguez, R. Hamilton, C.A. Parkos and A. Nusrat. Emory Univ.

3:45 256.8 P38MAPK is involved in loss of keratinocyte cohesion induced by plakoglobin but not desmoplakin depletion. C. Dehner, V. Spindler and J. Waschke. Ludwig Maximilians Univ., Munich.

4:00 256.9 The inflammatory cytokine IFNg regulates intestinal epithelial homeostasis by controlling the spatiotemporal localization of Akt, 14.3.3z and b-catenin. P. Nava, R. Kamekura, R. Hamilton, O. Medina-Contreras, K.N. Kolegraff, T.L. Denning, C. Parkos and A. Nusrat. CINVESTAV, Mexico City and Emory Univ. Sch. of Med.

4:15 256.10 Plakoglobin at adherens junctions after b-catenin loss: mechanism and biological implications in hepatocellular carcinoma. E.D. Wickline and S.P.S. Monga. Univ. of Pittsburgh.

257. LIVER GROWTH AND REGENERATION

Minisymposium


Chaired: G.K. miChalopoulos

CoChaired: J. reDDy

Liver Pathobiology

2:00 257.1 Wnt signaling in liver homeostasis and regeneration. J. Yang, B. Wiiliams and S.P. Monga. Univ. of Pittsburgh and Van Andel Res. Inst., Grand Rapids, MI.

2:15 257.2 Med1 subunit of the mediator complex is phosphorylated by AMPK. Y. Jia, N. Viswakarma, L. Bai, A. Vluggens, S. Sandra, P. Misra, T.J. Lukas, J. Borensztajn, Y-J. Zhu, B. Thimmapaya and J.K. Reddy. Northwestern Univ., Feinberg Sch. of Med. and Dr. Reddy’s Inst. of Life Sci., Hyderabad, India.

2:30 257.3 miR-21 inhibition overcomes ethanol suppression of rat liver regeneration. E. Juskeviciute, R.P. Dippold, A. Swarup and J.B. Hoek. Thomas Jefferson Univ. and Univ. of Maryland Baltimore.

2:45 257.4 Hypoxia-inducible factor-1a activation in hepatocytes promotes liver regeneration after acetaminophen overdose. B.L. Copple and J.P. Luyendyk. Michigan State Univ.

3:00 257.5 Triiodothyronine-induced hepatocyte proliferation requires b-catenin. M. Fanti, S. Singh, J. Stoops, A. Columbano and S.P.S. Monga. Univ. of Cagliari, Italy and Univ. of Pittsburgh Sch. of Med.

3:15 257.6 Concurrent inhibition of MET and EGFR in regenerating mice liver following a partial hepatectomy: effects on survival. S. Paranjpe, W.C. Bowen, T. Paranjpe, J. Luo, V. Bhave, D. Prosser, A. Lokshin and G.K. Michalopoulos. Univ. of Pittsburgh and Univ. of Pittsburgh Cancer Inst.

3:30 257.7 Thy1-positive cell transplantation activates the growth of small hepatocyte-like progenitor cells in rat livers treated with retrorsine and PH. T. Mitaka, N. Ichinohe, J. Kon, N. Tanimizu, Y. Nakamura, T. Mizuguchi and K. Hirata. Sapporo Med. Univ., Japan.

3:45 257.8 Mesenchymal stem cells from porcine bone marrow of the os femoris and the crista iliaca. P. Stock, S. Brückner, H. Tautenhahn, S. Pelz, M. Hempel and B. Christ. Univ. of Leipzig, Germany.

4:00 257.9 Effects of prototypical nuclear receptor ligands on the expression of enzymes and transporters in primary human hepatocytes. A. Ullrich, M. Keiser, A. Sauer, D. Runge, W. Siegmund and S. Oswald. PRIMACYT Cell Culture Technol. GmbH, Schwerin and Univ. Greifswald, Germany.

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MONDAY PATHOLOGY

72

259. ASIP MEMBERSHIP BUSINESS MEETING AND AWARDS PRESENTATION

Business Meeting


Chaired: e. unGer

260. ASIP CENTENNIAL CELEBRATION AT THE INSTITUTE OF CONTEMPORARY ART

Special Event

mon. 6:30 pm

258. ASIP PRESIDENTIAL SYMPOSIUM: HPV - REMAINING CHALLENGES IN TRANSLATIONAL SUCCESS STORY

Symposium


Chaired: e. unGer

Neoplasia

3:00 Introduction. E. Unger. Ctrs. for Dis. Control and Prevent.3:15 HPV16 DNA methylation in cervical cells is an

informative biomarker of the grade of neoplasia and invasive cancer. J. Brandsma. Yale Univ.

3:50 HPV-associated non-cervical cancers: burden and prevention potential. A. Chaturvedi. NCI, NIH.

4:25 The future of HPV vaccines. J. Schiller. NCI, NIH.

Pharmacology and Experimental Therapeutics

261. J.J. ABEL LECTURE


The John J. Abel Award in Pharmacology, supported by Pfizer, Inc., is named after the founder of ASPET, was established to stimulate fundamental research in pharmacology and experimental therapeutics by young investigators. Dr. Arthur Christopoulos was selected in recognition of his fundamental contributions to the field of analytical pharmacology and the study of G protein-coupled receptors, notably in his work on allosteric modulation and biased signaling of GPCRs.

8:30 Introduction. S. Lanier. Med. Univ. of South Carolina.8:35 Reciprocal relationships: the yin and yang of GPCR

allostery. A. Christopoulos. Monash Univ., Australia.

262. NEW KIDS ON THE BLOCK: ORGANIC CATION TRANSPORTERS AND PLASMA MEMBRANE MONOAMINE TRANSPORTER IN NEURODEGENERATIVE, PSYCHIATRIC AND ADDICTIVE DISORDERS

Symposium

(Sponsored by: The Divisions for Neuropharmacology; Drug Metabolism; Integrative Systems, Translational and Clinical Pharmacology; Molecular Pharmacology; and Toxicology)


Chaired: l.C. DaWs

9:30 Plasma membrane monoamine transporter: structure, function, and therapeutic potential for mental illness. J. Wang. Univ.of Washington.

10:00 Impaired monoamine and organic cation uptake in choroid plexus in mice with targeted disruption of the plasma membrane monoamine transporter (Slc29a4) gene. H. Duan and J. Wang. Univ. of Washington. (891.7)

10:20 Organic cation transporters and the plasma membrane monoamine transporter: uncovering novel targets to treat depression. L. C. Daws. Univ. of Texas Hlth. Sci. Ctr. at San Antonio.

10:50 Role of organic cation transporter-3 in stress effects on cocaine reinstatement. P. J. Gasser. Marquette Univ.

11:20 Neurotoxicity in animal models of Parkinson’s disease is mediated by the organic cation transporter-3. K. Tieu. Plymouth Univ., Peninsula Sch. of Med. and Dent.

263. ADVANCING DISCOVERIES FROM THE ACADEMIC LABORATORY TO THE MARKET

Symposium

(Sponsored by: The Divisions for Drug Discovery and Development and Pharmacology Education)


Chaired: r. leaDley

Career Development

9:30 Intellectual property protection: what, when, and how to protect and share your discovery. W. Gould.

10:05 Regulatory hurdles from bench to bedside. R. L. Dundore. InfaCare Pharmaceut. Corp.

10:40 What to know when working with technology transfer offices. R. J. Shebuski, Sr. Cardiovasc. Res. Consulting LLC.

11:15 Licensing: Do you have what they really want? C. Vlahos. Lilly Res. Labs.

11:50 Discussion.

PATHOLOGY/PHARMACOLOGY MONDAY

73

MON

264. NOVEL DYNAMICS OF CAMP: TOWARDS NEW THERAPEUTIC INTERVENTIONS THROUGH COMPARTMENTALIZED SIGNALING NETWORKS

Symposium

(Cosponsored by: The British Pharmacological Society and the ASPET Division for Molecular Pharmacology)


Chaired: m. sChmiDt anD m. peters-GolDen

9:30 Cyclic nucleotide signaling in subcellular compartments. M. Zaccolo. Univ. of Oxford, Balliol Col.

9:55 Adenylyl cyclase as orchestrators of cAMP microdomains. D.M.F. Cooper. Univ. of Cambridge.

10:20 Cell signaling in space and time. J. D. Scott. Univ. of Washington.

10:45 Structure, function and inhibition of G protein-coupled receptor kinases. J. Tesmer. Univ. of Michigan.

11:10 Dysregulation of cAMP networks in fibrotic lung disease. M. Peters-Golden. Univ. of Michigan Med. Sch.

11:35 Developing pharmacological probes targeting exchange protein directly activated by cAMP. X. Cheng, T. Tsalkova and F. Mei. Univ. of Texas Med. Branch. (656.3)

11:45 Modulation of the cAMP pathway by Pseudomonas aeruginosa quorum sensing molecules. L. Stoddart, W. Coward, P. Williams and S. Hill. Univ. of Nottingham Sch. of Molec. Med. Sci. (656.4)

11:55 Discussion.

265. ROLE OF THE COAGULATION CASCADE IN TISSUE INJURY AND DISEASE

Symposium

(Sponsored by: The Divisions for Toxicology; and Integrative Systems, Translational and Clinical Pharmacology)


Chaired: J.p. luyenDyK

9:30 Host prothrombin and fibrinogen are critical determinants of pathogen toxicity and host tissue damage following S. aureus infection. M. J. Flick. Cincinnati Children’s Hosp.

10:05 Fibrinogen: a biomarker and therapeutic candidate in kidney damage. V. S. Vaidya. Harvard Med. Sch.

10:40 Contribution of coagulation proteases to the vascular inflammation in sickle cell disease. R. Pawlinski. Univ. of North Carolina at Chapel Hill.

11:15 Liver let die: coagulation decides. J. P. Luyendyk. Michigan State Univ.

11:50 Discussion

266. FATTY ACID ACTIVATION OF G PROTEIN-COUPLED RECEPTORS: BASIC AND CLINICAL PERSPECTIVES

Symposium

(ASPET gratefully acknowledges the support of an educational grant from the Institut de Reserches and Janssen Research and Development, LLC)


Chaired: G. milliGan anD C. BrisCoe

9:30 Overview of the free fatty acid receptor family and the enigma of GPR120. C. Briscoe. Janssen.

10:05 Developing novel ligands for free fatty acid receptors. G. Milligan. Univ. of Glasgow.

10:40 GPR40 as a potential target for the treatment of type 2 diabetes. V. Poitout. Univ. of Montreal.

11:15 GLPG0974, a selective FFA2 antagonist: a promising approach for treatment of neutrophil driven disorders? J. Beetens. Galapagos NV.

11:50 Phosphorylation and internalization of short splicing variant of the omega 3 fatty acid sensor,GPR120. O.B. Sanchez-Reyes, J.A. Castillo-Badillo, M.T. Romero-Avila, Y. Takei, A. Hirasawa, G. Tsujimoto, R. Villalobos-Molina and J.A. García-Sáinz. UNAM, Mexico City, Grad. Sch. of Pharmaceut. Sci. , Kyoto Univ. and Col. Fac.-Iztacala, UNAM, Tlalnepantla. (1173.5)

267. CANADIAN SOCIETY OF PHARMACOLOGY AND THERAPEUTICS TRAINEE ORAL PRESENTATIONS

Oral


Chaired: F. parKinson

9:30 Introduction. F. Parkinson. Canadian Soc. of Pharmacol. and Therapeut.

9:35 Pharmacogenomics of vincristine-induced neurotoxicity in pediatric cancer patients. U. Amstutz. Univ. of British Columbia.

9:50 Characterization of the vascular phenotype of the equilibrative nucleoside transporter 1 knockout mouse. K. A. Best. Western Univ.

10:05 Genetic and clinical determinants of CYP3A4 activity in patients using 4b-hydroxycholesterol as an in vivo probe. I. Y. Gong. Western Univ.

10:20 Tricyclic compounds inhibit the OATP1A2 transporter. J. Lu. Univ. of Montreal.

10:35 Discussion.10:45 Therapeutic use of eNOS/Caveolin-1 antagonistic

peptides for endothelial dysfunction and atherogenesis. A. Sharma. Univ. of British Columbia.

11:00 Pharmacogenetics of warfarin safety and effectiveness in children. K. Shaw. Univ. of British Columbia.

11:15 Decreased nuclear receptor activity mediates down-regulation of drug metabolizing enzymes in chronic kidney disease through epigenetic modulation. T. Velenosi. Western Univ.

MONDAY PHARMACOLOGY

74

11:30 Surgery-induced inflammation reduces morphine distribution into cerebrospinal fluid. Y. Wang. Dalhousie Univ., Canada.

11:45 Discussion.

268. CANADIAN SOCIETY OF PHARMACOLOGY AND THERAPEUTICS AWARD RECIPIENT LECTURES



1:30 Senior Investigator Award Recipient. R. Tyndale. Univ. of Toronto.

2:30 Piafsky Young Investigator Award Recipient. B. Le Foll. Univ. of Toronto.

3:30 Distinguished Service and Education Award. J. Gray. Halifax, Nova Scotia.

269. DRUG METABOLISM EARLY CAREER ACHIEVEMENT AWARD LECTURE


The Drug Metabolism Early Career Scientist Award was established by ASPET’s Division for Drug Metabolism to recognize excellent original research by early career investigators in the area of drug metabolism and disposition. Dr. Nina Isoherranen was selected for her pioneering work in understanding complex drug-drug interactions and in understanding the role of drug metabolism during pregnancy and fetal development.

2:00 Introduction. K. Thummel. Univ. of Washington.2:05 The biochemistry and clinical significance of CYP26

enzymes in regulating retinoic acid homeostasis. N. Isoherranen. Univ. of Washington.

270. DRUG METABOLISM DIVISION JAMES GILLETTE AWARD AND PLATFORM SESSION

Oral


Chaired: W. BaCKes anD J. Jones

3:00 Chair’s introduction.3:05 270.1 Impact of development and genetic variation on

human hepatic CYP2B6 expression and activity. A. Gaedigk, G.P. Twist, R. Gaedigk, H. Dai, A.K. Riffel, J.S. Leeder and R.E. Pearce. Children’s Mercy Hosp. & Clins., Kansas City, MO.

3:20 270.2 Differences in the catalytic properties of CYP2B6s between common marmoset and human. S. Narimatsu, K. Mayumi, N. Hanioka, K. Masuda, S. Naito and A. Miyata. Grad. Sch. of Med., Dent. and Pharmaceut. Sci., Okayama Univ., Sch. of Pharm., Shujitsu Univ., Otsuka Pharmaceut. Factory and Grad. Sch. of Med. and Dent., Kagoshima Univ., Japan.

3:35 270.3 The effect of obesity and development on in vitro hepatic metabolism. G. Danielson, M. Chiney, H. Tam and L. Johnson. Univ. of Minnesota, Minneapolis.

3:50 270.4 Transport by OATP1B1 and OATP1B3 enhances cytotoxicity of EGCG and certain substituted quercetins. Y. Zhang, A. Hays, A. Noblett, M. Thapa, D.H. Hua and B. Hagenbuch. Univ. of Kansas Med. Ctr. and Kansas State Univ.

4:05 270.5 Evidence for epigenetic regulation of UGT1A1 protein expression and activity in healthy human livers. U. Yasar, D.J. Greenblatt, C. Guillemette and M.H. Court. Tufts Univ. Sch. of Med. and CHUQ, Laval Univ., Canada.

4:20 270.6 Active site gating controls substrate selectivity in cytosolic sulfotransferases. I.T. Cook, T. Wang, C.N. Falany and T. Leyh. Albert Einstein Col. of Med. and Univ. of Alabama at Birmingham.

4:35 270.7 The role of FcRn in the disposition, metabolism and pharmacokinetics of soluble non-crosslinking immune complexes. H.M. Alvarez , O-Y. So, S. Hsieh, N. Shinsky-Bjorde, H. Ma, Y. Song, Y. Pang, M. Marian and E. Escantón. Merck Res. Labs., Palo Alto.

5:00 270.8 Vitamin D receptor activation enhances benzo[a]pyrene metabolism via CYP1A1 expression in macrophages. M. Matsunawa, D. Akagi, S. Uno, K. Endo-Umeda, K. Ikeda and M. Makishima.

271. NEUROPHARMACOLOGY DIVISION POSTDOCTORAL SCIENTIST AWARD FINALISTS

Oral


3:00 Cannabinoid 1 receptor as therapeutic target in preventing chronic epilepsy. R. Di Maio. Univ. of Pittsburgh. (660.2)

3:20 Dimerization of G-protein coupled receptors in appetite regulation and food reward. H. Schellekens, T.G. Dinan and J.F. Cryan. Sch. of Pharm., University Col. Cork and Food for Hlth. Ireland, Cork. (881.3)

3:40 GPR158 and GPR179: a subfamily of orphan GPCRs as a new class of G protein signaling modulators. C. Orlandi, I. Masuho, E. Posokhova, Y. Cao, T. Ray, N. Hasan, R. Gregg and K. Martemyanov. The Scripps Res. Inst., Jupiter, FL and Univ. of Louisville. (1095.2)

4:00 Increased plasma ammonia concentration contributes to methamphetamine-induced blood-brain barrier damage. N.A. Northrop, L.E. Halpin and B.K. Yamamoto. Univ. of Toledo Col. of Med. (653.2)

4:20 Amphetamine and methamphetamine differentially regulate biophysical properties of dopamine transporter. K. Saha, L. Villarroel, P. Davari, S.E. Mehr, M.R. Zarindast, B. Richardson and H. Khoshbouei. Univ. of Florida and Tehran Univ. of Med. Sci. (885.4)

4:40 Cross-talk between beta and alpha 2 adrenergic receptors in sympathetic neurons relies on protein kinase A and spinophilin. C. Cottingham, R. Lu and Q. Wang. Univ. of Alabama at Birmingham. (882.2)

5:00 Keynote Speaker How to do big science on a modest budget: lessons from

deorphanizing a G protein-coupled receptor. L. Devi. Mount Sinai Sch. of Med.

PHARMACOLOGY MONDAY

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MON

272. MOLECULAR PHARMACOLOGY DIVISION POSTDOCTORAL SCIENTIST AWARD FINALISTS

Oral


3:00 Identification of substituted benzazepines as functionally selective ligands of the D1 dopamine receptor. J.L. Conroy, T.B. Doyle and D.R. Sibley. NINDS, NIH, Rockville. (655.3)

3:30 Development of a membrane-anchored chemerin receptor agonist as a novel modulator of inflammation. J.R. Doyle, S. Krishnaji, K. Kumar, B. Levy and A.S. Kopin. Tufts Med. Ctr., Tufts Univ. and Brigham and Women’s Hosp. (895.6)

4:00 Non-canonical signaling by GPCR-arrestin-Gbg ternary complexes. V.L. Wehbi, T.N. Feinstein and J-P. Vilardaga. Univ. of Pittsburgh Sch. of Med. (1172.8)

4:30 Keynote Speaker Probing G protein coupled receptors: a few of my favorite

experiments. B. Kobilka. Stanford Univ. Sch. of Med.

273. DRUG DISCOVERY AND DEVELOPMENT: GLIOBIOLOGY: EMERGING CONCEPTS IN NEURAL-GLIA INTERACTIONS IN CHRONIC DISEASE

Symposium


Chaired: m.F. Jarvis

3:00 Regulation of myelination by action potentials and an introduction to neuron-glia interactions. R. D. Fields. NICHD, NIH.

3:30 Reciprocal interactions between motor neurons and surrounding astrocytes in ALS. J. Weiss. Univ. of California, Irvine Sch. of Med.

4:00 Regeneration-related axon and Schwann cell interactions. D. Zochodne. Univ. of Calgary, Canada.

4:30 Spinal cord neural-glia interactions in chronic pain. R-R. Ji. Duke Univ. Med. Ctr.

5:00 The enigmatic P2X7 channel: physiology, pharmacology and implications in CNS disorders. A. Bhattacharya. Janssen Pharmaceut. Co. of Johnson & Johnson.

274. LOCAL CA2+ SIGNALS IN THE ENDOTHELIUM: KEY REGULATORS OF VASCULAR FUNCTION AND DYSFUNCTION

Symposium

(Sponsored by: The Division for Cardiovascular Pharmacology)


Chaired: m.t. nelson anD r.m. Bryan, Jr.

3:00 Multiple roles of endothelial Ca2+ signaling in resistance networks. S. Segal. Univ. of Missouri-Columbia.

3:25 TRPA1-induced endothelial calcium signals and vasodilation. S. Early. Colorado State Univ.

3:50 Differential regulation of SK and IK channels during endothelium-dependent hyperpolarization. K. A. Dora. Univ. of Oxford.

4:15 Elementary TRPV4 Ca2+ signals regulate endothelium-dependent vasodilation. S. K. Sonkusare. Univ. of Vermont.

4:40 Endothelial Ca2+ wavelets and myoendothelial feedback. D. G. Welsh. Univ. of Calgary, Canada.

5:15 Alteration of endothelial CaMKII in AngII-induced hypertensive mice. C. Charbel, F. Toussaint, A. Blanchette and J. Ledoux. Montreal Heart Inst. and Univ. of Montreal. (1090.1)

275. CANADIAN SOCIETY OF PHARMACOLOGY AND THERAPEUTICS ANNUAL GENERAL MEETING



Experimental Biology exhibitors offer the best tools and resources available in research today!

Join the exhibitors at 10:00 am for coffee and 2:00 pm for snacks and learn the latest and greatest from more than 300 companies.

MONDAY PHARMACOLOGY

76

APS President’s Symposium SeriesFrom Animals to Human Models of Disease

276. LESSONS FROM NEW ANIMAL MODELS OF CYSTIC FIBROSIS

Symposium

mon. 3:15 pm—Boston Convention & exhiBition Center, 210BC

Chaired: p. B. mCCray

Translational Physiology

3:15 Investigating the pathogenesis of CF lung disease in pigs with disruption of the CFTR gene. D. Stoltz. Univ. of Iowa.

3:45 Defects in exocrine pancreatic function and lipid metabolism: what CF ferrets and pigs are teaching us. A. Uc. Univ. of Iowa Carver Col. of Med.

4:15 Phenotype of the CFTR knockout ferret. J. Engelhardt. Univ. of Iowa.

4:45 Lessons learned from tissue-specific manipulation of CFTR in mice. M. Drumm. Case Western Reserve Univ.

277. CARL LUDWIG DISTINGUISHED LECTURESHIP OF THE APS NEURAL CONTROL AND AUTONOMIC REGULATION SECTION


Blood Pressure Regulation

Central Control of Homeostasis

Title: Central Mechanisms Regulating Coordinated Cardiovascular and Respiratory Function in Stress and Arousal

Speaker: R. A. Dampney. Univ. of Sydney.

278. CONCEPT INVENTORIES: ASSESSING CONCEPTS AND COMPETENCIES TO IMPROVE LEARNING AND TEACHING

Symposium

(Sponsored by: APS Teaching of Physiology Section)


Chaired: J. mCFarlanD

Education

8:00 Concept Inventories: How can we reliably assess deep understanding of core concepts? J. McFarland. Edmonds Community Col., Lynnwood, WA.

8:10 Host pathogen interaction conceptual inventory – from basic concepts to meaningful understanding. S. Balcom. Univ. of Maryland College Park.

8:40 Conceptual assessment in physiology: from core concepts, conceptual frameworks and misconceptions to conceptual assessment. J. McFarland. Edmonds Community Col., Lynnwood, WA.

9:10 Assessment of scientific process and reasoning skills (SPAST) – assessing core competencies. M. P. Wenderoth. Univ. of Washington.

9:40 Concept inventories – applications in physiology (facilitated discussion). W. H. Cliff. Niagara Univ.

279. HYPERTENSION: MECHANISMS AND CONSEQUENCES

Featured Topic

(Sponsored by: APS Water and Electrolyte Homeostasis Section)


Chaired: D. Kaputsa

8:00 Extracellular matrix genes Fmod and Prelp are candidate genes for salt-sensitive hypertension in females. L. Núñez, M. Hoffman, B. Xiao, M. Flister and C. Moreno Quinn. Med. Col. of Wisconsin. (906.3)

8:15 Matrix metalloproteinase inhibition protects kidney from adverse remodeling induced by hypertension. S. Pushpakumar, S. Kundu, N. Metreveli, S.C. Tyagi and U. Sen. Univ. of Louisville. (906.6)

8:30 Humoral immune system activation promotes the development of hypertension. K.W. Mathis, K. Wallace, B. Lamarca and M.J. Ryan. Univ. of Mississippi Med. Ctr. (906.4)

8:45 T cells mediate angiotensin II-induced aortic stiffening. J. Wu, S.R. Thabet, A. Kirabo, D.W. Trott, A. Goldstein, B.G. Hudson, M.S. Madhur, W. Chen and D.G. Harrison. Vanderbilt Univ. (906.7)

9:00 Endoplasmic reticulum stress is upstream of angiotensin-II-induced reactive oxygen species formation in the subfornical organ. C.N. Young, G. Wang, C. Iadecola, A.L. Mark and R.L. Davisson. Cornell Univ., Weill Cornell Med. Col. and Univ. of Iowa. (906.15)

9:15 Metabolic dysfunction in chronic intermittent hypoxia?role of hypothalamic peptides. T.P. Nedungadi, S.W. Mifflin and J.T. Cunningham. Univ. of North Texas Hlth. Sci. Ctr. (906.19)

9:30 PVN Gai2 protein-gated signal transduction—a renal nerve dependent mechanism required for sodium homeostasis and blood pressure regulation in Sprague-Dawley rats. R.D. Wainford and J.T. Kuwabara. Boston Univ. (906.18)

9:45 Downregulation of brain Ga12 blunts angiotensin II-induced hypertension. J. Gao and D.R. Kapusta. LSU Hlth. Sci. Ctr., New Orleans. (906.16)

Physiology

PHYSIOLOGY MONDAY

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MON

280. ION CHANNELS IN HEALTH AND DISEASE

Featured Topic

(Sponsored by: APS Cell and Molecular Physiology Section)


Chaired: K. hamilton anD C. BertuCCio

Transporters and Ion Channels

8:00 Sex-specific estrogen regulation of ion channels in intestine, kidney and airway epithelia. B. Harvey. Royal Col. of Surgeons-Ireland.

8:30 ROS-induced membrane lipid peroxidation impairs TRPV1 channels in the vasculature. J.G. Kmetz, D.J. DelloStritto, S. Sinha, B. Prudner, D.S. Damron and I.N. Bratz. Northeast Ohio Med. Univ. and Kent State. (913.48)

8:45 Epigallocatechin-3-gallate inhibits the effects of TGF-beta and IL-1B on ENaC expression in human alveolar epithelial cells. O. Phillips, R. Cox, J. Fukumoto, I. Fukumoto, P.T. Parthasarathy, V. Delic, T. Luong, R. Lockey and N. Kolliputi. Univ. of South Florida Morsani Col. of Med. and Univ. of South Florida. (913.41)

9:00 TGF-b1 attenuates CFTR-mediated anion secretion across porcine vas deferens epithelia via the p38 MAPK pathway. S. Yi, F. Pierucci-Alves and B.D. Schultz. Kansas State Univ. (913.13)

9:15 Chloride channels: role in apoptosis, cell motility and chemotherapy resistance. E.K. Hoffmann, K.S. Jacobsen, A. Schwab, D. Sauter, I.H. Lambert and K.A. Poulsen. Univ. of Copenhagen and Westfälische Wilhelms-Univ Münster. (913.15)

9:30 Characterization of the trafficking of a Ca2+-activated K+ channel (KCa3.1) in polarized epithelial cells. C.A. Bertuccio and D. Devor. Univ. of Pittsburgh. (913.20)

9:45 ATP regulates Cl- and K+ channels in human pancreatic ducts. I. Novak, J. Wang and M. Hayashi. Univ. of Copenhagen and Kansai Med. Univ., Osaka. (913.18)

281. NATRIURETIC PEPTIDES IN PLANTS AND AS BIOLOGIC MARKERS AND TREATMENT OF CONGESTIVE HEART FAILURE AND CANCER

Symposium

(Sponsored by: American Federation for Medical Research)


Chaired: D. l. vesely

8:00 Personalizing designer natriuretic peptides for human cardiovascular and metabolic disease. J. C. Burnett, Jr. Mayo Clin. and Fndn.

8:30 Natriuretic peptides as biologic markers and for treatment of congestive heart failure. J. L. Januzzi. Harvard Med. Sch., Massachusetts Gen. Hosp.

9:00 Natriuretic peptides’ metabolic targets for the treatment of cancer. D. L. Vesely. Univ. of South Florida Morsani Sch. of Med.

9:30 Plant natriuretic peptides as systemic regulators of plant homeostasis and responses to pathogens. C. Gehring. King Abdullah Univ. of Sci. and Technol., Saudi Arabia.

282. ORIGINS OF CELLS THAT CONTRIBUTE TO PULMONARY EPITHELIAL AND VASCULAR REMODELING

Featured Topic

(Sponsored by: APS Respiration Section)


Chaired: s. maJKa anD D. alvarez

8:00 Pericytes: roles in vascular stability and remodeling. P. D’Amore. Harvard Med. Sch.

8:30 Endothelial progenitor cells in pulmonary arterial hypertension. J.E. Loehr, E. Tremblay, M-R. Blanchet, S. Bonnet and S. Provencher. Quebec Heart and Lung Inst. Res. Ctr., Laval Univ. (915.1)

8:45 Rac1 inhibition decreases branching in embryonic mouse lung explants. S. Danopoulos, D. Warburton, R. Kim, S. Bellusci and D. Al Alam. Univ. of Southern California Children’s Hosp. of Los Angeles. (915.2)

9:00 Cellular mechanisms of pulmonary remodeling. D. Kotton. Boston Univ. Sch. of Med.

9:30 Lack of CFTR in a cystic fibrosis pig model disrupts airway smooth muscle development. D.A. Stoltz, N.D. Gansemer, M.V. Rector, D. Bouzek, T.O. Moninger and D.K. Meyerholz. Univ. of Iowa. (915.3)

9:45 Rab38 targets to and regulates the sizes of a subset of larger and older LBs in the alveolar type II pneumocyte. S. Huang, Z. Zhang, K.M. DeBolt, S. Mulugeta, S.I. Feinstein, A.B. Fisher and L. Zhang. Univ. of Pennsylvania Sch. of Med. (915.4)

283. PUBLISHING 101: HOW TO GET YOUR WORK PUBLISHED IN APS JOURNALS AND AVOID MINEFIELDS ALONG THE WAY

Symposium

(Sponsored by: APS Publications Committee)


Chaired: h. raFF anD r. sCheman

Career Development

8:00 Preparing your work for publication in APS journals: choosing a journal, authorship and peer review. H. Raff. Med. Col. of Wisconsin.

8:30 Ethical minefields I: plagiarism and data duplication. K. Barrett. UCSD.

8:50 Ethical minefields II: image manipulation. C. Bennett. APS.

9:10 Meet the Editors Panel. D. J. Paterson, S. Matalon, P. Wagner. Univ. of Oxford, Univ. of Alabama at Birmingham and UCSD.

MONDAY PHYSIOLOGY

78

284. RECENT ADVANCES IN THE MECHANISMS OF RENAL TRANSPORT

Featured Topic

(Sponsored by: APS Renal Section)


Chaired: J. l. pluzniCK anD m. mamenKo

8:00 Feedback inhibition of the epithelial Na+ channel during acute sodium loading in vivo. A.B. Patel, G. Frindt and L.G. Palmer. Weill Cornell Med. Col. (912.16)

8:15 Proteolytic processing of epithelial sodium channels by prostasin in human kidneys. R.M. Zachar, P. Svenningsen, N. Marcussen, S. Walter, K. Skjoedt and B.L. Jensen. Univ. of Southern Denmark and Odense Univ. Hosp. (912.18)

8:30 Separate control of TRPV4 activity and trafficking in the distal nephron. M. Mamenko, O.L. Zaika, N. Boukelmoune, J. Berrout, R.G. O’Neil and O. Pochynyuk. Univ. of Texas Hlth. Sci. Ctr. at Houston. (912.4)

8:45 Angiotensin II stimulates basolateral 10 pS Cl channels, a main type of Cl channels in the thick ascending limb. L. Wang, R. Gu, P. Wu, M. Wang, H. Luan, L. Fan and W-H. Wang. Harbin Med. Univ., China and New York Med. Col. (912.21)

9:00 Expression and function of the Ca2+-dependent SK3 K+ channel in mouse cortical collecting duct: regulation by TRPV4. J. Berrout, M. Mamenko, O.L. Zaika, O. Pochynyuk and R.G. O’Neil. Univ. Texas Hlth. Sci. Ctr. at Houston. (912.14)

9:15 PHA2D proteins, KLHL3-CUL3 and WNK1, form an endocytic switch signal that controls the renal K+ excretory channel, ROMK. P. Welling, B-Y. Kim, J.B. Wade, R. Coleman and L. Fang. Univ. of Maryland Med. Sch. (912.13)

9:30 Genetic ablation of aquaporin-2 in the mouse connecting tubules results in defective renal water handling. M.L.A. Kortenoeven, N.B. Pedersen, R.L. Miller, A. Rojek and R.A. Fenton. Aarhus Univ., Denmark and Univ. of Utah. (1111.8)

9:45 Transgenic mice expressing UT-A1, but lacking UT-A3, have intact urine concentrating ability. J.D. Klein, O. Fröhlich, A.C. Mistry, K.J. Kent, C.F. Martin and J.M. Sands. Emory Univ. (1111.17)

285. SIGNALING MECHANISMS IN CARDIAC, LYMPHATIC AND SMOOTH MUSCLE CONTRACTION

Featured Topic

(Sponsored by: APS Cardiovascular Section)


Chaired: s. p. ChaKraBorty anD J. p. sCallan

Hypoxia and Oxidative Stress


8:00 Signaling mechanisms and cytoskeletal regulation in smooth muscle contractility. K. Morgan. Boston Univ.

8:30 Vasoactive agonists induce oscillatory changes in vascular smooth muscle cell stiffness and alter cytoskeletal architecture. Z. Hong, Z. Sun, Z. Li, J.P. Trzeciakowski and G.A. Meininger. Univ. of Missouri-Columbia and Texas A&M Univ. (921.4)

8:45 P21-activated kinase inhibits vascular reactivity via inhibition of MLCK. J. Chu, D. Bhattarai, C.S. Cox and K. Uray. Univ. of Texas Med. Sch. at Houston. (921.1)

9:00 Thick and thin filament regulations in cardiac and lymphatic muscle contraction. M. Muthuchamy. Texas A&M Hlth. Sci. Ctr. Col. of Med.

9:30 Role of voltage-dependent calcium channels in stretch-induced lymphatic vessel contractions. S.S. Lee and P-Y. von der Weid. Univ. of Calgary, Canada. (681.11)

9:45 N-terminal region of cardiac myosin binding protein-C impairs myofilament function. J.P. Sarkey, S. Govindan, X. Chen, Y. Ge, P.P. de Tombe and S. Sadayappan. Loyola Univ. Med. Ctr. and Univ. of Wisconsin-Madison. (921.7)

286. TRAINEE HIGHLIGHTS IN PHYSIOLOGICAL GENOMICS

Special Session

(Sponsored by: APS Physiological Genomics Group)


Chaired: h. G. KlemCKe anD C. moreno-Quinn

8:00 Introduction.8:03 Identification of candidate susceptibility genes in a

murine model of respiratory syncytial virus-induced bronchiolitis. K.C. Verhein, M. High, J. Marzec, Z. McCaw, T. Wiltshire, Y. Chen, A. Burkholder, L. Klimczak, D. Fargo and S.R. Kleeberger. NIEHS, NIH, Research Triangle Park and Univ. of North Carolina at Chapel Hill. (1212.4)

8:16 Differential gene expression profiles produced by a high fat diet in white and brown adipose. J.L. Faulkner, J.R. Gomolak, M.R. Garrett and S.P. Didion. Univ. of Mississippi Med. Ctr. (738.3)

8:29 Generation of caveolin-2 overexpressing C. elegans and their response to stress. E. Shi, H.N. Fridolfsson, E. Kwan, J.M. Schilling and H.H. Patel. UCSD and VA San Diego Healthcare Syst. (1211.4)

8:42 Angiotensin II stimulates renin synthesis and secretion in mouse collecting duct M-1 cells via a PKC alpha-mediated cAMP stimulation mechanism. L. Liu, L.S. Lara, A.A. Gonzalez, C.R.T. Bourgeois, D.M. Seth and M.C. Prieto. Tulane Univ. Sch. of Med. and Fed. Univ. of Rio de Janeiro. (1165.16)

8:55 Discovery of new renal ang II processing enzyme activity using mass spectrometry and gene deletion mouse models. N. Grobe, K.M. Elased, E.S.B. Salem, S.B. Gurley, F.S. Ong, K.E. Bernstein, A.H. Schmaier and M. Morris. Wright State Univ., Duke Univ. and Durham VA Med. Ctrs., Cedars-Sinai Med. Ctr. and Univ. Hosps. Case Med. Ctr., Case Western Reserve Univ. (1165.18)

PHYSIOLOGY MONDAY

79

MON

9:08 Plekha7, a candidate gene for human hypertension, plays a critical role in the regulation of intracellular calcium. B. Endres, J.R.C. Priestley, O. Palygin, M. Hoffman, C. Moreno, J. Lombard, H.J. Jacob and A.M. Geurts. Med. Col. of Wisconsin. (955.2)

9:21 Production of angiotensin within the SFO is sufficient to increase ERK1/2 and CREB activity in the SFO and PVN. J. Coble, J. Grobe, M. Cassell and C.D. Sigmund. Univ. of Iowa. (1165.11)

9:34 Neutral sphingomyelinase 3 modulates myotube density and is regulated by microRNA-133. E.M. Wolf, J.J. McCarthy, J.S. Moylan, J.D. Smith and M.B. Reid. Univ. of Kentucky. (737.4)

9:47 Ang-(1-7) induced MAS1 receptor-mediated angiogenesis in the rat microvasculature. B.R. Hoffmann, T.J. Stodola, J.R. Wagner and A.S. Greene. Med. Col. of Wisconsin. (1165.9)

287. CENTRAL MECHANISMS OF AUTONOMIC REGULATION DURING STRESS

Minisymposium

(Sponsored by: APS Neural Control and Autonomic Regulation Section)


Chaired: r. a. Dampney

9:00 The contribution of orexin to the cardiovascular response of psychological stress. P. Carrive. Univ. of New South Wales.

9:20 Sympathetic outflow for psychological stress-induced thermogenesis in brown adipose tissue. K. Nakamura. Kyoto Univ.

9:40 Cortical circuitry associated with cardiovascular arousal during exercise in humans. K. Shoemaker. Univ. of Western Ontario.

288. BRAINSTEM AUTONOMIC PATHWAY IN HEALTH AND DISEASE

Featured Topic

(Sponsored by: APS Central Nervous System Section)


Chaired: t. BaBiC



10:30 Plasticity of vagal circuits in acute pancreatitis. T. Babic. Penn State.

11:00 Plasticity of cardiovascular afferent integration in disease states. S. Mifflin. Univ. of North Texas Hlth. Sci. Ctr.

11:30 Evidence that 5-HT neurotransmission within the nucleus tractus solitarii differentially modulates glutamate release via 5-HT3 and 5-HT1A receptors. P.S. Hosford, A.G. Ramage and S. Mifflin. University Col. London and Univ. of North Texas Hlth. Sci. Ctr. (932.6)

11:45 Responses of neurons in the caudal medullary lateral tegmental field to visceral inputs and vestibular stimulation in vertical planes. B.J. Yates, J.D. Moy, D.J. Miller, M.F. Catanzaro, B.D. Boyle, S.W. Ogburn, L.A. Cotter and A.A. McCall. Univ. of Pittsburgh. (932.4)

12:00 Optogenetic stimulation of the locus coeruleus noradrenergic neurons increase inhibitory neurotransmission to cardiac vagal neurons in the nucleus ambiguus. X. Wang, R.A. Pinol and D. Mendelowitz. George Washington Univ. (932.1)

12:15 Astrocyte damage but not microglial infiltration in the nucleus tractus solitarii attenuates cardiovascular reflexes. W. Talman, S. Jones and L-H. Lin. Carver Col. of Med., Univ. of Iowa and VA Healthcare Syst. (932.2)

289. CELL STRESS IN LUNG DISEASE

Featured Topic



Chaired: m. Koval anD s. muluGeta

10:30 Roles of the ER stress sensors IRE1a and IRE1b in airway inflammation and mucin production. C. M.P. Ribeiro. Univ. of North Carolina at Chapel Hill.

11:00 Endoplasmic reticulum stress linked to cystic fibrosis cellular manifestations through PI3-kinase p110alpha/histone deacetylase 6 signaling cascade. S.M. Rymut, D.A. Corey and T.J. Kelley. Case Western Reserve Univ. (914.4)

11:15 Role of GADD34 in age-related differences in hyperoxia-induced stress signaling. J. Shenberger and Y.M. Wu. Penn State Col. of Med. and Baystate Children’s Hosp., Springfield, MA. (914.9)

11:30 Distinct mechanisms for epithelial cell dysfunction and lung fibrosis caused by different surfactant protein C mutations. S. Mulugeta. Univ. of Pennsylvania Med. Ctr.

12:00 Modulation of aENaC mRNA expression under different stresses: implication of its 3’UTR. F. Migneault, M. Pascariu, A. Dagenais and Y. Berthiaume. IRCM, Montreal. (914.6)

12:15 Softening of hyperoxia treated alveolar epithelial cells reduces stretch-induced injury. K.R. Wilhelm, E. Roan, M. Gosh and C.M. Waters. Col. of Med., Univ. of Tennessee Hlth. Sci. Ctr., Memphis and Univ. of Memphis. (914.11)

290. CEPS TRAINEE SESSION

Featured Topic

(Sponsored by: APS Comparative and Evolutionary Physiology Section)


Chaired: h. Contreras anD s. KirKton

10:30 Temperature-dependent variation in respiratory patterns and spiracular control in Rhodnius prolixus. E. Heinrich and T. Bradley. Univ. of California, Irvine. (1149.6)

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10:45 Temperature influences CO2/pH-sensitivity in locus coeruleus neurons of the bullfrog, Lithobates catesbeianus . J. Santin and L. Hartzler. Wright State Univ. (714.12)

11:00 Angiotensin II and developmental cardiovascular-renal interactions in embryonic chickens. C.A. Mueller, D.A. Crossley II and W.W. Burggren. Univ. of North Texas. (714.18)

11:15 A comparison of the cardiovascular responses to anemia in digesting Burmese pythons and American alligators. C.E. Slay, S. Enok, T. Wang and J.W. Hicks. Univ. of California, Irvine and Aarhus Univ., Denmark. (714.16)

11:30 Prolonged fasting induces insulin resistance in the Northern elephant seal pup. J.A. Viscarra, D.E. Crocker and R.M. Ortiz. Sch. of Nat. Sci., Univ. of California, Merced and Sonoma State Univ. (714.21)

11:45 Prolactin as an osmoregulatory hormone in zebrafish: transcriptional regulation of a Na+/Cl- cotransporter in the gill. J. Breves, S. Serizier, V. Goffin, S. McCormick and R. Karlstrom. Univ. of Massachusetts Amherst and INSERM, Univ. of Paris Descartes. (714.6)

12:00 Development and plasticity of innate immune function in altricial house sparrow nestlings. T.L. Killpack and W.H. Karasov. Univ. of Wisconsin-Madison. (714.19)

12:15 Development of endothermy in the Pekin duck (Anas pekin). S. Ream, A. Duquaine, S.K. Goy Sirsat, T.S. Sirsat and E.M. Dzialowski. Univ. of North Texas. (1149.17)

291. MECHANOSENSORY MECHANISMS IN THE KIDNEY

Symposium

(Sponsored by: APS Renal Section)


Chaired: o. poChynyuK anD a. starusChenKo


10:30 The polycystins and ciliary sensing. M. J. Caplan. Yale Univ. Sch. of Med.

11:00 (Hemi)channel-mediated, mechanosensitive ATP release in the collecting duct. J. Peti-Peterdi. Univ. of Southern California.

11:30 Mechanically stimulated nucleotide release in renal epithelia. J. Leipziger. Aarhus Univ., Denmark.

12:00 A role for bENaC as a mechanosensor in renal VSMC. H. A. Drummond. Univ. of Mississippi Med. Ctr.

292. MICROCIRCULATORY SOCIETY YOUNG INVESTIGATOR SYMPOSIUM

Symposium

(Sponsored by: The Microcirculatory Society)


Chaired: W. l. murFee anD t. CarDinal

10:30 Aging attenuates spontaneous endothelial Ca2+ events with altered perivascular nerve function in mouse mesenteric arteries in vivo. E.B. Westcott and S.S. Segal. Univ. of Missouri-Columbia. (901.3)

10:50 Mechanisms of endothelial dysfunction in penetrating cerebral arterioles of DOCA-salt hypertensive rats. P.W. Pires, N. Matin, H. Garver, W.F. Jackson and A.M. Dorrance. Michigan State Univ. (678.7)

11:10 Functional vasodilation is impaired in arterialized capillaries following ischemia. J.P. Cutts, F. MacGabhann and T. Cardinal. Cal Poly San Luis Obispo and Johns Hopkins Univ. (685.21)

11:30 Glucagon-like peptide-1 attenuates agonist-stimulated cytosolic free calcium ([Ca2+]i) signaling and the production of F2a-isoprostane in endothelial cells. V.A. Richardson, C.S. Weber, R.M. Lynch and B.B. Dokken. Univ. of Arizona. (900.5)

11:50 Platelets of humans with type 2 diabetes (DM2) exhibit fewer prostacyclin receptor (IPR) binding sites as well as decreased iloprost-mediated cAMP accumulation. S. Knebel, R. Sprague, M. Ellsworth and A. Stephenson. Saint Louis Univ. (900.4)

12:00 Discussion.

293. NOVEL ROLES OF HORMONES IN BLOOD PRESSURE REGULATION

Featured Topic



Chaired: J. sullivan anD J. sasser

10:30 Sex difference in blood pressure regulation in aging spontaneously hypertensive rats. R.O. Maranon, J. Do Carmo and J.F. Reckelhoff. Univ. of Mississippi Med. Ctr. (904.2)

10:45 Ang (1-7) has a greater contribution to the blood pressure lowering effects of AT1 receptor blockade in female spontaneously hypertensive rats compared to males. M. Zimmerman and J. Sullivan. Georgia Regents Univ. (904.3)

11:00 17b-Estradiol attenuates renal TNFa and the progression of hypertension in mice with systemic lupus erythematosus. E.L. Gilbert, K.W. Mathis and M.J. Ryan. Univ. of Mississippi Med. Ctr. (904.4)

11:15 Testosterone modulates sodium-regulating hormones in women with PCOS. N. Stachenfeld, M.M. Wenner and H.S. Taylor. John B. Pierce Lab., Yale Sch. of Med. and Univ. of Delaware. (904.5)

11:30 Improvement of salt-sensitive hypertension in SS-Mstnem1Mcwi rats. D.W. Stepp, R.H. Dunlap and J.D. Mintz. Georgia Hlth. Sci. Univ. (904.9)

11:45 Targeting of 11b-hydroxysteroid dehydrogenase type 2 in the nucleus of the solitary tract links salt appetite and hypertension. L.C. Evans, C. Kenyon, J. Mullins, M. Holmes and M. Bailey. Univ. of Edinburgh, U.K. (904.8)

12:00 Potentiation of angiotensin II (Ang II) hypertension in rats by sensitizing pre-treatment with intermittent ICV Ang II injections. S.C. Clayton, S. Hurley, T. Beltz and A.K. Johnson. Univ. of Iowa. (904.7)

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12:15 Vasopressin increases blood pressure without inducing pulmonary hypertension in a Sus scrofa model of hemorrhage. J. Sarkar, C.F.T. Uyehara, W.M. Ichimura, L-A.M. Murata, A.K. Sato, C.A. Hernandez and C.L. Allen. Tripler Army Med. Ctr., HI. (904.10)

294. SOLOMON A. BERSON DISTINGUISHED LECTURESHIP OF THE APS ENDOCRINOLOGY AND METABOLISM SECTION



Title: Extra-Nuclear Estrogen Receptors: Functions for Physiology and Pathophysiology

Speaker: E. R. Levin. Univ. of California, Irvine.

295. THERAPEUTIC CRANIAL COOLING AND SELECTIVE BRAIN COOLING IN HUMANS

Symposium

(Sponsored by: APS Environmental and Exercise Physiology Section)


Chaired: m. White anD C. CranDall

10:30 Effects of active and passive heat stress on mechanisms modulating cerebral perfusion. C. Crandall. Univ. of Texas Southwestern Med. Ctr.

10:55 Characteristics of heat-induced hyperventilation in humans: implications for SBC? T. Nishiyasu. Univ. of Tsukuba.

11:20 Cerebral heat balance at rest and during exercise with hyperthermia. L. Nybo. Univ. of Copenhagen.

11:45 Avenues of cranial heat exchange and human SBC. M. White. Simon Fraser Univ., Canada.

12:10 Therapeutic cranial cooling in humans. B. Harris. NHS Lothian and Univ. of Edinburgh.

296. TIGHT JUNCTIONS IN EPITHELIAL HOMEOSTASIS: BEYOND PARACELLULAR BARRIER

Featured Topic

(Sponsored by: APS Gastrointestinal and Liver Physiology Section)


Chaired: l. shen


10:30 Signaling functions of ZO-1. K. Matter. University Col. London.

11:00 The dual roles of aromatic residue Y67 in claudin-2 pore cation selectivity. J. Li, M. Zhuo, L. Pei and A.S.L. Yu. Univ. of Kansas Med. Ctr. and Univ. of Southern California. (954.1)

11:15 Zonula occludens-1 is required for epithelial morphogenesis and lumen development. M. Odenwald, N.E. Joseph, A.S. Fanning and J.R. Turner. Univ. of Chicago and Univ. of North Carolina at Chapel Hill. (954.10)

11:30 Contributions of occludin to epithelial homeostasis. L. Shen. Univ. of Chicago.

12:00 Simulated microgravity increases susceptibility of intestinal epithelial cells to acetaldehyde-induced barrier dysfunction. C.A. Stork, R.R. Marchelletta, G.K. Prisk and D.F. McCole. UCSD. (954.12)

12:15 Role of zonula occludens in reduced epithelial cell proliferation by hypertonic stress. X. Qiao, I. Roth, E. Feraille and U. Hasler. Univ. of Genva. (954.7)

297. WIGGERS AWARD FEATURED TOPIC: NOVEL PATHWAYS REGULATING MICROVASCULAR TONE AND FUNCTION

Featured Topic



Chaired: D. Gutterman

10:30 Shifting mechanisms of endothelium-dependent dilation in the human microcirculation. D. D. Gutterman. Med. Col. of Wisconsin.

11:00 A novel role for spontaneous endothelial cell calcium activity in the vascular myogenic response. P. Bagher, T. Beleznai, Y. Kansui, R. Mitchell, C.J. Garland and K.A. Dora. Univ. of Oxford and Kyushu Univ., Japan. (924.3)

11:15 Abnormal ER and mitochondrial communication underlies ER stress in cerebrovascular insulin resistance. P.V.G. Katakam, I. Rutkai, D. Liu, S.M. Grovenburg, A.O. Gordon and D.W. Busija. Tulane Univ. Sch. of Med. (924.5)

11:30 Involvement of TRPM4 in pressure and agonist-induced vasoconstriction in the cerebral microcirculation. Y. Li, R.L. Baylie and J.E. Brayden. Univ. of Vermont. (924.6)

11:45 Role of vascular hyperpolarization, nitric oxide, and prostaglandins in reactive hyperemia in healthy humans. A.R. Crecelius, J.C. Richards, G.J. Luckasen, D.G. Larson and F.A. Dinenno. Colorado State Univ. and Univ. of Colorado Hlth., Loveland. (924.1)

12:00 Nitric oxide stress uncovers pM b2-adrenergic mediated dilation to isoproterenol mimicked by preventing clathrin endosome formation. M. Frame, B. Calizo, A.M. Dewar and S. Scarlata. Stony Brook Univ. (924.4)

12:15 Endogenously-generated lipid peroxidation products dilate rat cerebral arteries by activating TRPA1 channels in the endothelium. M.N. Sullivan, A. Bruhl and S. Earley. Colorado State Univ. (924.2)

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298. EDWARD F. ADOLPH DISTINGUISHED LECTURESHIP OF THE APS ENVIRONMENTAL AND EXERCISE PHYSIOLOGY SECTION


Title: The Remarkable Anti-aging Effects of Aerobic Exercise on Arteries

Speaker: D. R. Seals. Univ. of Colorado Boulder.

299. BONE PHYSIOLOGY UNDER ENVIRONMENTAL STRESS

Symposium

(Sponsored by: APS Comparative and Evolutionary Biology Section)


Chaired: t. oWerKoWiCz

3:15 Bone as buffer during metabolic acidosis. D. C. Jackson. Brown Univ.

3:40 Bone quality in lactating mammals and their offspring. W. R. Hood. Auburn Univ.

4:05 Bone protection during inactivity: strategies of small and large hibernators. S. W. Donahue. Colorado State Univ.

4:30 Temperature effects on the growth plate and its vasculature. M. A. Serrat. Marshall Univ.

4:55 Atmospheric oxygen effects bone vascularity, growth and biomechanics. T. Owerkowicz. California State Univ., San Bernardino.

300. CARL W. GOTTSCHALK DISTINGUISHED LECTURESHIP OF THE APS RENAL SECTION


Title: Regulation of Renal Urea Transport

Speaker: J. Sands. Emory Univ. Sch. of Med.

301. CENTRAL NERVOUS SYSTEM MODULATION OF CARDIORESPIRATORY RESPONSES TO HYPOXIA

Featured Topic

(Sponsored by: APS Hypoxia Group)


Chaired: i. solomon

Hypoxia and Oxidative Stress


3:15 Modulation of centrally-mediated hypoxic respiratory excitation. I. C. Solomon. Stony Brook Univ.

3:45 Role of brainstem serotonergic neurons and receptors in mediating the cardiorespiratory responses to hypoxia. D. Mendelowitz. George Washington Univ. Med. Ctr.

4:15 Central modulation of arterial chemo-baroreflex control by propofol during severe arterial hypoxia in the rabbit. A.W. Quail, D.B. Cottee, R. Roach and S.W. White. Univ. of Newcastle and Hunter Med. Res. Inst., Australia. (1135.3)

4:30 Knockdown of tyrosine hydroxylase in the nucleus of the solitary tract reduces elevated blood pressure during chronic intermittent hypoxia. C.S. Bathina, A. Rajulapati, M. Franzke, K. Yamamoto and S. Mifflin. Univ. of North Texas Hlth. Sci. Ctr. (1135.4)

4:45 Endogenous hydrogen sulfide in the rostral ventrolateral medulla mediates ventilatory response induced by hypoxia. A.F. Donatti, M. Kwiatkoski, R.N. Soriano, E.C. Carnio and L.G.S. Branco. Univ. of São Paulo, Ribeirão Preto. (1135.12)

5:00 Developmental hyperoxia attenuates hypoxic ventilatory depression in neonatal rats. R.W. Bavis, S.H. Grandgeorge and C.B. Hill. Bates Col. (1135.10)

302. GASTRIC CONTROL OF APPETITE AND ENERGY METABOLISM

Symposium

(Sponsored by: APS Neural Control and Autonomic Regulation Section)


Chaired: W. zhanG anD y. taChe

Metabolic Diseases

3:15 Yin and Yang: the gastric X-A like cells as possible dual regulator of food intake. Y. Tache. UCLA.

3:45 The neuronal mechanism by which Roux-en-Y gastric bypass reduced food intake and body weight. L. Kaplan. Harvard Med. Sch.

4:15 Gastric fuel sensing and food intake. W. Zhang. Univ. of Michigan.

4:45 Cross talk between the gut and adipose tissue leptins. M. Bendavan. Univ. of Montreal.

303. HYPERTENSION: FROM FLIES TO HUMANS

Symposium



Chaired: p. a. Jose

3:15 Renal proximal tubule cells exfoliated into the urine predict the salt-sensitive phenotype. R. Felder. Univ. of Virginia Sch. of Med.

3:45 Epigenetics in human essential hypertension. A. Baccarelli. Havard Sch. of Publ. Hlth.

4:15 Pharmacogenomics of essential hypertension. P. A. Jose. Univ. of Maryland Sch. of Med., Baltimore.

4:45 Drosophila and humans. M. F. Romero. Mayo Clin. Col. of Med.

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304. JOSEPH ERLANGER DISTINGUISHED LECTURESHIP OF THE APS CENTRAL NERVOUS SYSTEM SECTION



Title: Verney’s Osmoreceptor: An Integrated Unit Comprising Ion Channels, Glial Cells and Mechanosensitive Neurons

Speaker: C. W. Bourque. McGill Univ. and Montreal Gen. Hosp.

305. MICROBIAL REGULATION OF MEMBRANE TRANSPORT

Symposium

(Sponsored by: APS Cell and Molecular Physiology Section)


Chaired: J. BomBerGer anD m. m. Greenlee


3:15 Respiratory epithelial cell responses to virus infection. A. Pekosz. Johns Hopkins Univ.

3:45 Respiratory virus-mediated iron secretion promotes chronic bacterial colonization in the lung. J. Bomberger. Univ. of Pittsburgh.

4:15 Impact of enteropathogenic E. coli on intestinal epithelial tight junctions and transporters. G. Hecht. Univ. of Illinois Col. of Med. at Chicago.

4:45 The role of CFTR in bacterial-macrophage interactions. M. O’Riordan. Univ. of Michigan Med. Sch.

306. MOLECULAR BIOENGINEERING

Symposium

(Sponsored by: Biomedical Engineering Society)


Chaired: C. Chen anD D. irvine

3:15 Engineering the immune response through hitch-hiking therapeutics. D. Irvine. MIT.

3:40 Engineered proteins as next-generation diagnostics and therapeutics. J. Cochran. Stanford Univ.

4:05 Improving adoptive T cell therapy for cancers through synthetic biology. W. Wong. Boston Univ.

4:30 Single-molecule approaches to dissecting networked multiple protein functions. M. Diehl. Rice Univ.

4:55 Engineering cellular mechanotransduction. C. Chen. Univ. of Pennsylvania.

307. NOVEL SIGNALING MOLECULES IN VASCULAR INJURY AND INFLAMMATION

Featured Topic



Chaired: m. hamBlin anD p. roCiC

Inflammation and Immune Responses


3:15 Role of CCN proteins in aldosterone-mediated vascular injury. J. Leopold. Brigham and Women’s Hosp.

3:45 Enhanced angiotensin-aldosterone activation of mTOR/S6K-1 promotes vascular inflammation, oxidative stress and endothelial dysfunction. J. Sowers. Univ. of Missouri-Columbia.

4:15 Novel mitochondrial mechanisms mediate enhanced vasodilation of rat middle cerebral arteries to mitochondrial depolarization following ischemia-reperfusion injury. I. Rutkai, E.A. Wappler, P.V.G. Katakam, D. Liu and D.W. Busija. Tulane Univ. Sch. of Med. (1131.10)

4:30 Activation of formyl peptide receptors induces relaxation and reduces contraction in resistance arteries. C.F. Wenceslau, C.G. McCarthy, S. Goulopoulou and R.C. Webb. Georgia Hlth. Sci. Univ. (1131.11)

4:45 FoxO induced inhibition of secreted molecule signaling pathways: role in promoting angiostasis in the ischemic muscle. E.A. Roudier, M. Milkiewicz and T.L. Haas. York Univ., Canada and Pomeranian Med. Univ., Poland. (1131.13)

5:00 Telomere uncapping causes cellular senescence and inflammation in arteries: implications for arterial aging. R.G. Morgan, S.J. Ives, L.A. Lesniewski, R.M. Cawthon, R.H.I. Andtbacka, R.D. Noyes, E.L. Denchi, R.S. Richardson and A.J. Donato. Univ. of Utah, George E. Wahlen DVA Med. Ctr. and The Scripps Res. Inst. (1131.1)

308. PROGRAMMING THE LUNG: EPIGENETIC MECHANISMS

Symposium



Chaired: l. KoBziK anD s. matalon

3:15 Epigenetic mechanisms in lung development. M. Ramirez. Boston Univ. Sch. of Med.

3:45 Prenatal programming of airway reactivity. J. Hollingsworth. Duke Univ.

4:15 Epigenetic immune programming in early life by environmental exposures. B. P. Lawrence. Univ. of Rochester Sch. of Med. and Dent.

4:45 Reversing prenatal programming for allergy. H. Renz. Phillips Univ., Marburg.

MONDAY PHYSIOLOGY

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