m 30, a solid mass with calcification and cystic space on left lung base
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M 30, A solid mass with calcification and cystic space on left lung base. Chondroid Hamartoma. Chondroid Hamartoma. Chondroid Hamartoma. - PowerPoint PPT PresentationTRANSCRIPT
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M 30, A solid mass with calcification and cystic space on left lung base
Chondroid Hamartoma
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Chondroid Hamartoma
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Chondroid Hamartoma
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Definition: Benign neoplasms composed of varying proportions of mesenchymal tissues, such as cartilage, fat, connective tissue and smooth muscle, typically combined with entrapped respiratory epithelium.
Histogenesis: Histogenesis is unknown, although genetic studies indicated a neoplastic rather than hamartomatous origin
Somatic genetics: Pulmonary hamartomas have a high frequency of genetic mutations, similar to those seen in other benign mesenchymal neoplasms such as lipomas. Most notable are mutations of high-mobility group (HMG) proteins, a family of non-histon, chromatin-associated proteins, which are important in regulating chromatin architecture and gene expression. Mutation in the regions 6p21 and 12q14-15 are most commonly found.