lv rv matthew kay, dsc. dept of electrical and computer engineering dept of pharmacology and...
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![Page 1: LV RV Matthew Kay, DSc. Dept of Electrical and Computer Engineering Dept of Pharmacology and Physiology Electrical rotors: a cause of sudden death. Rotors](https://reader035.vdocuments.us/reader035/viewer/2022062422/56649e715503460f94b6f360/html5/thumbnails/1.jpg)
LV
RV
Matthew Kay, DSc.Dept of Electrical and Computer Engineering
Dept of Pharmacology and Physiology
Electrical rotors: a cause of sudden
death.
Rotors can be studied in great detail using
computational models.
![Page 2: LV RV Matthew Kay, DSc. Dept of Electrical and Computer Engineering Dept of Pharmacology and Physiology Electrical rotors: a cause of sudden death. Rotors](https://reader035.vdocuments.us/reader035/viewer/2022062422/56649e715503460f94b6f360/html5/thumbnails/2.jpg)
Panoramic imaging reveals a dozen short lived rotors during VF in healthy swine hearts.
Rotors rarely lasted longer than 1 sec. Stable epicardial rotors do not maintain VF. Continual formation of new rotors is critical for VF maintenance.
![Page 3: LV RV Matthew Kay, DSc. Dept of Electrical and Computer Engineering Dept of Pharmacology and Physiology Electrical rotors: a cause of sudden death. Rotors](https://reader035.vdocuments.us/reader035/viewer/2022062422/56649e715503460f94b6f360/html5/thumbnails/3.jpg)
Fast fluorescence imaging reveals successful antitachycardia pacing.
Intracellular calcium transients from monolayers of cardiomyocytes show rotor termination by paced-induced rotor drift.
Antitachycardia therapy to prevent ventricular fibrillation.
Action potentials from the epicardium of small animal hearts (rabbit) show rotor termination by wavefront - wavefront collisions.
![Page 4: LV RV Matthew Kay, DSc. Dept of Electrical and Computer Engineering Dept of Pharmacology and Physiology Electrical rotors: a cause of sudden death. Rotors](https://reader035.vdocuments.us/reader035/viewer/2022062422/56649e715503460f94b6f360/html5/thumbnails/4.jpg)
Ischemic tissue is proarrhythmic by two mechanisms: delayed conduction or block and spontaneous (ectopic) activation.
When and where might one mechanism dominate?
Excised rat/rabbit heart model of local ischemia.