lung cancer and copd the two sides of the coin

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LUNG CANCER AND COPDThe two sides of the coinManuel G. Cosio (Padova/Montreal)

An adaptive immune inflammation, and probably autoimmunity, is important in the development of COPD.

Could this inflammation be a factor in the development of lung cancer in smokers?LUNG CANCER AND COPDThe two sides of the coin

T-cell inflammation in COPD: EmphysemaCosio M, Saetta M, Agusti A: N Engl J Med 2009;360:2445-54

From Lung tissueCD8+ inflammation in small airwaysNormal COPD

Saetta M: Am J Respir Crit Care Med 1998;157:822826.

Majo J, Ghezzo H, Cosio M. Eur Respir J, 2001;17:946-953Saetta M Di Stefano A, Turato G et al: Am J Resp Crit Care Med;1998, 157: 822 T-cells in the lung are:Oligoclonal. Activated: CD4+ express a Th-1 profile CD8+ express perforin and granzimes.

The inflammatory infiltrate persists after smoking cessation. These are signs of antigenic activation of the adaptive immune system

Retamales J et al. Am j Respir Crit Care Med:2001; 164; 469Lung inflammation in smokersB-cells: oligoclonal lymphoid follicles

Inflammation & emphysemawith or without CS exposureAdoptive transfer of pathogenic T Cells induce COPD-like Disease. Motz. Am J Respir Crit Care Med Vol 181. pp 12231233, 2010When T cells from cigarette smoke exposed mice are transferred to mice deprived of Tcells (Rag2-/-) they are able to induce emphysema even without further exposure to cigarette smoke.

The autoimmune mechanism in COPD:the steps approach. N Engl J Med 2009;360:2445-54

STEP 1STEP 2STEP 3GOLD 0, I ?

GOLD I, II ?GOLD III, IV? innate immunity Adaptive immunity AUTOIMMUNITYTolerance failure.Genetic predisposition.Epigenetics ?COPD: EVASION AND PROGRESSIONi m m u n i t yResolution of inflammation: RegulonsInhibiting protein translation.Promoting mRNA decaytolerance

Immune system in smokersImmunosuppressed:

DC presenting and maturationPMNs and AMsT-cell anergyB-cellsImmunoglobulinsMarkers and mediators

Martin R. Stmpfli: NATURE Reviews | Immunology; volume 9 | May 2009 | 377

1551 patients with COPD followed for 15 years1.- Evasion/progression phenotype?

2.- Patient selection for studies

3.-Responses to treatment 4.- Searching for Biomarkers

5.- Understanding other comorbidities: cancer Data from J.M. Marin Trigo

Grafico1

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by fef1

FEV1% PREgold1gold 2gold 3gold 4

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9911.70%29.60%14.80%3.90%

93

92

91

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86

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79

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76

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56

87

47

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fev1%

age

fev1%

sort fev1

agefev1%Paq/aoagefev1%Paq/ao

ORTIN GIMENO, VICENTE4910051795945

GRACIA FLETA, JOSE779953532449

VINTANED LANGA, RODOLFO599345685140

TOVIO ORTEGA, JUAN769260522940

LABARTA CUEN, MARIANO749160615670

CAMPOS CABAERO, CALIXTO529130633147

LERIN CAVERO, MIGUEL618675665850

BEZANA MARTIN, ANIANO728640734740

BUDRIA ABENIA, GREGORIO748390723678

GRACIA ESTEBAN, ENRIQUE628390635543

FRANCO VILLARTE, JACINTO498264737289

CALVO GONZALEZ, JOSELUIS548124704645

MARTIN JARAUTA, RODOLFO518034647828

HERNANDEZ SEBASTIAN, ALBERTO588050696030

SALINAS LACAMBRA,JOS468060518034

CISNEROS TORRUBIA, LAZARO757950576163

GRACIA GRANELL, JOSE MIGUEL4979417328100

LAHUERTA ROJO, ANTONIO647828757950

TABUENCA ABADIA, MANUEL647860749160

RUBIO GRANDE, ALEJANDRO437647437647

PEREZ RODRIGO, PEDRO5676100696547

CABALLERO MERINO, FIDENCIO6675485676100

CUBEL BENEDICTO, JULIAN767553667548

MURO VELLOSILLO, JESUS727352643942

CABEZA CABEZA,JOSE M7372894910051

GIMENO VALERO, RAFAEL617260694068

PALACIOS CASADO, PILAR4970406233140

GONZALEZ CORREAS, LORENZO736940736940

BERJANO VICENTE, RAMIRO706756497040

ASENSIO VAL, ALFREDO606687647860

MALLO DIAZ, FRANCISCO696547498264

BELLO GIL, LORENZO556525588050

BETES PALOMO, CARLOS536339714636

BURILLO VAL, EDUARDO736258635230

AZNAR ABANSES, ROBERTO576163735040

GASCON MANERO, RODOLFO696030345722

CASAOLA MOREN, JORGE795945706756

ANCHELERGUES MURILLO, EDUARDO665850695780

MARTINEZ SIMON, JOSELUIS345722735047

MARTIN MORENO, SEVERIANO695780413352

AURE DIESTE, JOSE785775468060

NADAL BINTANED, PEDRO765750824660

BELTRAN CARBO, RAFAEL615670606687

ASENSIO BLAZQUEZ, JULIAN685670769260

MUOZ GREGORIO, JOSE635543617260

DE DIOS EXPOSITO, AGAPITO655440785775

MOLINE POLO, SAGRARIO635230599345

MAINAR LUO, MAXIMO685140748390

DIARTE ALPUENTE, JESUS665175744682

PERNA PERNA, LUIS735040727352

FERNANDEZ TORRIJOS, JESUS735047534870

BURRIEL FRANCES, MANUEL675051765750

IGLESIAS ALVAREZ, ANTONIO655045736258

BARRIGA GARCIA, BLAS534870675051

CALDERON RONCO, SIMON734859655440

CALVO FERNANDEZ, EMILIO714850613141

ALCAINE PASTOR, JORGE734740779953

GAA VISANZAY, FELIX704645618675

LONGARES BARRANCO, JOSE MARIA714636652335

AGUILAR MARTINEZ, MARIANO824660704650

FUENTES BIELA, GUILLERMO744682655045

ALADREN VICENTE, FRANCISCO704650728640

CALVO MARTINEZ, JUAN534480497941

AGON RIVERA, EMILIO764425532037

MADRE BURILLO, JOSE VITORIO694068556525

MARTINEZ NAVARRO, ROBERTO643942783680

ALONSO PEA, EULOGIO723678734859

AMBROJ HERNANDEZ, JESUS783680628390

GOMEZ GALLEGO, SANTOS6233140536339

TOMAS ROCHE, JOSE MARIA413352685670

DEL RIO COMIN, PASCUAL633147767553

CRUZ PIERNAGORDA, DOMINGO613141548124

MONGE CLAVER, ALEJANDRO522940534480

ARAGONES GIMENO, JOSE M7328100665175

AINA BAILO, AURELIO532449714850

FRANCO NAVARRO, JOSE MARIA652335529130

ARAGON IGLESIAS, BERNARDO532037764425

lung cancerby fev post

NombreTfonoFecha PFPHEdadSexoTallaPesobmiIMCDisneaTOSBODFumador activoPaq/aoFEV1L PREFEV1% PREFVCL PREFVC%PREFEV1/FVC PRE25-75 L PRE25-75 % PREFEV1L POSTFEV1% POSTFVCL POSTFVC% POSTFEV1/FVC POST25-75 L POST25-75 % POSTDLCODLCO/VATLC%FRC%RV%RV/TLCIC/TLCSat O2INGRESOSingresos EPOCFECHASINGRESOS cvsFECHASINGRESOS otrosFECHASURGENCIAS POR EPOCFECHASEXITUSCAUSATIEMPO SEGUIMIENTO (meses)LLAMADO tfnoCOMENTARIOS

GRACIA FLETA, JOSE9763536148/2/002486167711.585823.2231100532.04993.31120620.81332.221073.36122661.054311089121131135510.359414/24/034/15/023/17/061/10/0019/2/2002, 15/4/2002, 7/2/2003, 7/2/2003, 23/4/2003, 14/12/2003, 23/12/2003, 21/10/2005, 27/10/2005, 18/2/20061CA BRONCOGNICO (Febrero 2006)70si

ORTIN GIMENO, VICENTE9764758903/30/003837434911.677225.8260101513.261004.9123671.77463.411044.97124692.3561826495600614/2/2004, 23/2/2004, 17/3/2004, 29/4/2004, 17/6/2004, 28/6/2004313/2/2004, 16/6/2004, 27/6/20041CA BRONCOGNICO ( Julio 2006)76SI

TOVIO ORTEGA, JUAN9763720234/28/004268327611.687125.2250101602.32924.23126550.76282.541004.4131580.78297762953017/14/00222/5/02,9/7/0201CA BRONCOGENICO (Abril 2002)22SI

VINTANED LANGA, RODOLFO97641478012/1/00365875911.728328.1282111452.96934.57114651.55443.03954.5112671.73491816963024/05/06,14/06/06,25/06/0601CA BRONCOGENICO (DEC,2008)96NO

BEZANA MARTIN, ANIANO9763746042/23/993087407211.627026.7270100402.04863.81123540.87312.28954.18134550.9434767095400424/6/1999, 3/9/1999, 4/5/2006, 7/6/200632/9/1997, 3/5/2006, 7/6/20061CA BRONCOGNICO (Junio 2006)88NO

CAMPOS CABAERO, CALIXTO97627027412/3/032659905211.678630.83111302.91914.37112671.72462.96934.28109691.89515449975230/5/2006, 28/9/2006033/4/2005,13/4/2005, 12/5/2005812/1/2004, 9/2/2004, 19/4/2004, 7/6/2004, 2/4/2005, 12/4/2005, 31/7/2006, 28/9/20061CA BRONCOGENICO(Septiembre 2006)33SI

LABARTA CUEN, MARIANO9761650831/19/058786207411.657728.3282010602.23913.33103671.15422.24913.4105660.983640409550112/1/0641/9/2005, 13/5/2005, 11/8/2006, 10/1/200751/8/2006, 8/8/2006, 11/8/2006, 1/12/2006, 8/1/20071CA BRONCOGNICO ( Enero 2007)24SI

GRACIA ESTEBAN, ENRIQUE9764181806/11/016010816211.67429292010902.14833.1496681.21392.34903.4590681.3415253911378/6/2005, 15/12/2005, 20/6/2007, 11/10/2007, 26/12/2007, 20/2/2008, 6/3/200818/10/05522/4/2005, 31/5/2005, 21/6/2005, 9/7/2005, 25/4/20071522/4/2005, 6/6/2005, 9/7/2005, 9/8/2005, 14/12/2005, 10/7/2006, 28/8/2006, 10/5/2007, 17/5/2007, 18/6/2007, 16/7/2007, 11/10/2007, 25/12/2007, 18/2/2008, 6/3/20081CA BRONCOGNICO (Marzo 2008)81SI

LERIN CAVERO, MIGUEL9763955721/12/993237686111.728428.4281001752.7864.11104661.31382.78894.23106661.42424747939985320.4495215/23/99016/20/0111/23/031CA BRONCOGNICO (Julio 2003)54SI

LAHUERTA ROJO, ANTONIO9765608286/13/062316726411.657728.3282110282.14783.89111550.87282.37863.68105641.314211999978223/3/2007, 13/4/20070623/6/2006, 7/7/2006, 6/8/2006, 10/8/2006, 1/9/2006, 18/9/200638/2/2007, 23/3/2007, 13/4/20081CA BRONCOGNICO ( Abril 2007)22SI

CALVO GONZALEZ, JOSELUIS9765186301/10/972148125411.667226.1260000242.5813.7198671.47412.64863.5593692.26173669250225/3/1998, 27/4/1998329/9/1997, 9/10/1997, 2/2/199801CA BRONCOGNICO( Abril 1998)15NO

MARTIN JARAUTA, RODOLFO9765138364/11/006031285111.718127.7280001342.72803.34104631.51392.87854.25102671.754697979530033/8/2000, 18/6/2001, 29/8/2002229/6/2001, 29/8/20021CA BRONCOGNICO ( Agosto 2002)28SI

FRANCO VILLARTE, JACINTO9767326109/29/993255004911.65722.32201642.45824.26119571.19322.5844.09114611.3236554696300315/12/1999, 30/12/1999, 12/1/2000313/10/1999, 30/12/1999, 11/1/20011CA BRONCOGNICO ( Mayo 2000)32NO

HERNANDEZ SEBASTIAN, ALBERTO9764338868/9/98266695811.78128281100502.52803.7495681.8512.63843.98101661.544492859210013/11/07210/3/2007, 24/5/20071CA BRONCOGNICO ( Mayo 2007)105SI

CISNEROS TORRUBIA, LAZARO9764961429/26/973330777511.616424.72500501.78792.5786691381.84822.7793670.84328796787670390.43953019/29/0224/10/1999, 10/1/2004422/9/1999, 16/6/2000, 29/9/2002, 10/1/20041CA BRONCOGNICO ( Enero 2004)76SI

GONZALEZ CORREAS, LORENZO9762752703/24/994685967311.618131.2312010401.59693.68121430.4151.89823.83126500.67258974176230262640.2493653/3/2001, 8/4/2001, 26/4/2001, 19/6/2002, 10/3/2003019/19/011424/7/2000, 17/2/2001, 2/3/2001, 22/3/2001, 7/4/2001, 26/4/2001, 29/9/2001, 30/9/2001, 3/2/2002, 18/6/2002, 2/7/2002, 30/9/2002, 25/11/2002, 9/3/20031CA BRONCOGENICO ( Marzo 2003)48SI

CABEZA CABEZA,JOSE M9763972568/16/053816507311.78328.7293020891.66722.4891670.92361.86812.6597701.14449810096126121520.396300310/11/2005, 19/10/2006, 1/3/2007429/11/2005, 27/9/2006, 18/10/2006, 10/2/20071CA BRONCOGNICO ( Abril 2007)20NO

GIMENO VALERO, RAFAEL9764169795/9/056794766111.648230.530.50100602.02723.6102560.75232.26813.72106611.01319490122133166510.495200215/11/2007, 24/2/2008111/12/071CA BRONCOGNICO (Abril 2008)35SI

SALINAS LACAMBRA,JOS97644362710/22/997329814611.778426.8270100606.02804.4395681.92462.99794.392691.99485356883033/12/1999, 18/5/2000, 13/8/20000312/5/2000, 18/5/2000, 13/8/20001CA BRONCOGNICO ( Sept 2007)11NO

BUDRIA ABENIA, GREGORIO9761772415/20/054116477411.696623.1231101901.85832.9109640.86341.75792.95111590.68277561150236230640.16962017/15/0619/21/06214/7/2006, 13/8/20061CA BRONCOGENICO (Dic-2006)24SI

GRACIA GRANELL, JOSE MIGUEL9762906443/1/995557764911.828826.6270000413.11794.7698651.67403.11794.5694681.8545616198600624/7/2004, 1/8/2004, 25/8/2004, 21/10/2005, 26/10/2005, 20/11/2005214/11/2005, 20/11/20051CA BRONCOGNICO (Junio 2006)79si

BERJANO VICENTE, RAMIRO97649624511/3/003892737011.536427.3272110561.38672.2485620.61231.6782.3589680.91341059796214/3/2003018/12/0213/4/031CA BRONCOGENICO ( Octubre 2002)29NO

TABUENCA ABADIA, MANUEL9764397869/23/975860676411.758828.7291000602.47784.24104580.85252.44774.11101591.03319288939188340.4996500523/9/2002, 9/12/2002, 22/10/2002, 12/7/2004, 14/3/2007510/7/2002, 11/4/2003, 9/2/2005, 1/2/2007, 17/3/20071CA BRONCOGNICO ( Marzo 2007)114NO

AURE DIESTE, JOSE97641184510/2/995113027811.687827.62800751.41572.885500.43161.9774.07123470.51198791120152179630.29961111/5/060098/2/2003, 6/9/2004, 11/9/2006,31/10/2006, 2/11/2006, 5/11/2006, 1/5/2007, 3/5/2007, 13/5/20071CA BRONCOGNICO (Agosto 2007)94SI

RUBIO GRANDE, ALEJANDRO9764968638/13/024416764311.777724.6251101472.95764.74100621.23292.95764.6298641.4233555799114112330.4497600620/3/2006, 31/3/2006, 14/5/2006, 31/10/2006, 12/1/2007, 22/1/200768/3/2006, 6/5/2006, 18/9/2006, 27/10/2006, 30/10/2006, 22/1/20071CA BRONCOGNICO ( Enero 2007)53NO

CABALLERO MERINO, FIDENCIO9763991089/26/003936556611.66224.2242010481.85753.27104570.56191.85753.14100590.6421646596412/3/01110/31/0022/3/2001, 18/7/2003531/10/2000, 3/2/2001, 2/3/2001, 7/7/2001, 17/7/20011CA BRONCOGNICO ( Julio 2001)36NO

ASENSIO VAL, ALFREDO97617816910/14/042078206011.746320.8212020872.13663.6589580.83242.45753.7792651.3639515298500516/11/2004, 30/11/2004, 12/12/2004, 3/6/2005, 7/11/2005112/12/041CA BRONCOGNICO (2006)24SI

BURILLO VAL, EDUARDO9763893082/7/003809037311.628532.43210581.35622.3881570.46191.63752.4684660.883659719398116560.259210018/30/0618/30/061CA BRONCOGNICO (Febrero 2001)80SI

PEREZ RODRIGO, PEDRO9763737156/20/008498255611.738829.42900001002.54763.8192671.81492.46743.3180742.0556565995000001CA BRONCOGNICO ( Febrero2006)68SI

MURO VELLOSILLO, JESUS9765905172/12/994307357211.717224.6251000522.02732.9982671.18402.06743.2489641346671103131146560.319320028/4/2002, 27/9/200237/4/2002, 27/9/2002, 7/1/20031CA BRONCOGNICO (Enero 2003)47SI

CUBEL BENEDICTO, JULIAN9765954478/5/982880277611.687325.9261000531.9753.296590.78291.86733.46103540.6223596189000025/2/2000, 26/10/20011CA BRONCOGENICO Julio 200473SI

PALACIOS CASADO, PILAR9764314242/5/973620214901.484520.5201011401.42702.3699600.73241.43712.3899600.792568599240042/1/2001, 26/2/2001, 28/5/2001, 6/3/200357/12/1998, 27/5/2001, 9/1/2003, 19/1/2003, 6/3/20031CA BRONCOGNICO ( Marzo 2003)73SI

MALLO DIAZ, FRANCISCO9763521617/16/044728826911.736020202010471.92654.01105480.64212.08704.35114480.752442449730031/9/2004, 27/10/2004, 28/1/2008824/11/2005, 25/11/2005, 22/5/2006, 24/7/2006, 8/8/2006, 11/12/2006, 28/1/2008, 21/2/20081CA BRONCOGNICO ( Febrero 2008)43SI

BELTRAN CARBO, RAFAEL9764208899/30/982472666111.739030.1301100701.77564.33108410.64192.16684.85120450.812412494140171215540.369450056/8/2001, 21/8/2001, 25/10/2001, 10/12/2001, 5/2/200251/8/2001, 25/10/2001, 15/11/2001, 9/12/2001, 4/2/20021CA BRONCO.+METAS (Febrero 2002)41SI

BELLO GIL, LORENZO9763926943/26/991696825511.675218.6193020252653.5893560.9252.1683.7297570.96275456117166173350.259760228/11/2002, 10/1/2003430/7/2002, 5/9/2002, 23/9/2002, 7/10/2002830/7/2002, 21/9/2002, 20/11/2002, 28/11/2002, 7/1/2003, 8/1/2003, 9/1/2003, 10/1/20031CA BRONCOGENICO (Marzo 2003)48SI

MARTINEZ SIMON, JOSELUIS9763713818/3/028220693411.738428.1281101222.22574.1989540.91202.66675.11108521.12246857116151204470.369815321/9/2007, 2/10/2007, 26/10/200701217/1/2005, 28/1/2005, 9/3/2005, 21/3/2005, 13/8/2005, 22/8/2005, 30/1/2006, 7/7/2006, 25/5/2007, 14/6/2007, 10/7/2007, 31/7/20071515/12/2004, 12/8/2005, 30/1/2006, 7/7/2006, 14/1/2007, 11/6/207, 14/6/2007, 7/7/2007, 9/7/2007, 10/7/2007, 28/7/2007, 30/7/2007, 21/9/2007, 1/10/2007, 25/10/20071CA BRONCOGNICO ( Noviembre 2007)63NO

ASENSIO BLAZQUEZ, JULIAN9762927083/26/982840826811.595120.2202021701.33562.4380550.55191.59672.6186610.9312833118/31/980001CA BRONCOGNICO (Sept 1999)18NO

MUOZ GREGORIO, JOSE97651203212/10/991576166311.699633.6342010431.63553.0581540.81251.94663.4993560.91269386116136185590.3793327/3/2003, 22/4/2003019/30/0225/3/2003, 21/4/20031CA BRONCOGNICO ( Abril 2005)64NO

BETES PALOMO, CARLOS9763995515/6/022898985311.627227.4272111391.86633.5498520.85241.93663.97110490.78227267113121150470.41968321/7/2005, 15/8/2005, 24/6/200500524/11/2004, 15/5/2005, 29/5/2005, 27/6/2005, 9/6/2006115/10/2004, 29/11/2004, 5/3/2005, 29/5/2005, 20/7/2005, 18/10/2005, 8/6/2006, 29/12/2006, 20/3/2007, 5/4/2007, 10/5/20071CA BRONCOGNICO (Mayo 2007)60SI

AZNAR ABANSES, ROBERTO9764747269/10/015166065711.769029.1292110632.1614.2599490.76212.22654.51105490.81227772117144169480.3710017/3/0717/3/071CA BRONCOGNICO ( Agosto 2007)71SI

NADAL BINTANED, PEDRO9765524531/31/021484387611.646724.9251100501.34572.8491470.55211.52652.9394520.441710011093102106490.3793500528/3/2005, 4/5/2005, 9/6/2005, 22/10/2006, 27/12/2006322/10/206, 23/12/2006, 27/12/20061CA BRONCOGNICO (Enero 2007)60SI

Mean64.21.864.8

CASAOLA MOREN, JORGE9763892346/22/993309127911.738729.12910451.58592.6173610.72271.71642.9583580.772971713018/13/99220/7/1999, 10/4/2004413/8/1999, 3/5/2000, 1/11/2002, 10/4/20041CA BRONCOGNICO (Abril 2004)58SI

MARTIN MORENO, SEVERIANO4/19/985361216911.594618.2182131801.33573.1103430.67241.4603.22107440.7254344155217238650.196217/6/1998, 5/9/200111/20/00317/6/2003, 19/8/2003, 15/9/2003519/1/2000, 4/9/2001, 17/8/2003, 14/9/2003, 11/10/20031CA BRONCOGNICO ( Octubre 2003)66SI

ANCHELERGUES MURILLO, EDUARDO97629026210/17/017984356611.578032.532.51110501.37582.3378590.64221.38592.5686540.612198116115140174630.2996000001CA BRONCOGNICO ( 12 Abril 2008)78SI

GASCON MANERO, RODOLFO9764247725/31/991430976911.759330.43001301.82603.1580580.73231.79592.8272640.87287796300321/6/1999, 28/6/1999, 24/10/199918/16/001CA BRONCOGNICO ( Agosto 2001)27SI

PERNA PERNA, LUIS9764414053/26/034101547311.76522.522.53130401.35503.79107360.58201.59593.98112400.68242928116126141590.24901111/8/0600217/05/2006 26/05/20011CA BRONCOGENICO ( Noviembre 2006)44SI

ALCAINE PASTOR, JORGE9764277353/5/972832227311.645219.319,310401.16472.578460.43161.41582.8589490.5821739510017/31/00212/5/1999, 17/5/19991CA BRONCOGNICO ( 2002)60SI

MAINAR LUO, MAXIMO9762299003/23/00524346811.694515.81600401.42513.4194420.55181.59573.3593470.7233837148218246640.2960000218/10/2003, 13/4/20051CA BRONBOGNICO ( Mayo 2005)62SI

FERNANDEZ TORRIJOS, JESUS9763762953/6/973781577311.648230.530.5212471.22502.3674520.61221.38572.6783520.5219106129124185204680.1692200227/8/2004, 23/10/2004327/8/2004, 25/9/2004, 23/10/20041CA BRONCOGNICO ( Octubre 2004)91NO

AGUILAR MARTINEZ, MARIANO97635876912/4/014025668211.677225.82600601.07462.0766520.52221.28552.4478520.58244294200225/3/2002, 12/11/2002111/12/021CA BRONCOGENICO (2003)24SI

BARRIGA GARCIA, BLAS9763913861/3/002269725311.788426.526.51011701.75484.1391420.5131.97544.293470.66178679124163209530.3497400430/1/2006, 17/5/2006, 4/6/2006, 26/6/20061111/10/2001, 12/4/2003, 26/4/2003, 27/4/2006, 28/2/2006, 23/4/2006, 9/5/2006, 16/5/2006, 3/6/2006, 24/6/2006, 25/6/20061CA BRONCOGNICO (Enero 2006)72NO

DE DIOS EXPOSITO, AGAPITO9762702057/15/971435206511.658430.9312021401.46542.6677550.56181.46542.8983560.79257481113135173590.3391647/4/2000, 29/7/2000, 29/12/2000, 28/5/2002228/4/1999, 30/9/20020112/1/1999, 28/4/19999, 18/11/1999, 2/12/1999, 7/4/2000, 29/7/2000, 18/12/2000, 29/12/2000, 2/10/2001, 27/5/2002, 29/9/20021CA BRONCOGNICO (Febrero 2003)44si

BURRIEL FRANCES, MANUEL9764285768/3/001240026711.646825.3252020511.3502.8284460.39441.39532.3269600.826877794211/14/01012/13/01420/11/2000, 13/1/2001, 27/1/2001, 13/2/20031CA BRONCOGNICO (Febrero 2001)30NO

CALVO MARTINEZ, JUAN9762167373/24/049070445311.688429.8303131801.4443.1780440.63171.71533.0276571.03287689128168231610.3197618/2/060530/5/2005, 26/6/2005, 15/8/2005, 10/9/2005, 11/7/2006410/9/2005, 10/7/2006, 21/7/2006, 2/8/20061CA BRONCOGNICO( Agosto 2006)29NO

MOLINE POLO, SAGRARIO97635384910/10/056435666301.514821.1211120300.93521.5672600.42160.93521.674580.4115405992100111/3/06419/5/2006, 18/8/2006, 6/9/2006, 3/11/20061CA BRONCOGNICO ( Nov 2006)13NO

CALDERON RONCO, SIMON97634239910/4/002305467311.668229.8302121591.21482.0662590.61221.33522.4373550.53194148961115/4/0376/3/2002, 24/3/2002, 14/6/2002, 24/8/2002, 8/9/2002, 17/12/2002, 14/1/2004311/4/2002, 11/4/2003, 26/3/200484/3/2002, 24/3/2002, 14/6/2002, 24/8/2002, 8/9/2002, 10/4/2003, 4/5/2003, 25/3/20041CA BRONCOGNICO (Marzo 2004)41NO

CALVO FERNANDEZ, EMILIO97627455610/25/97463437111.726522221111501.36483.2888410.44151.48523.1585470.31104848102146132500.23951006/21/02211/6/2002, 21/6/20021CA BRONCOGNICO( Junio 2002)54NO

AGON RIVERA, EMILIO9761072733/4/993497977611.665118.518,543130251.07442.268490.68261.28522.5278510.67254594000015/13/991CA PULMON ( Diciembre 1999)9SI

ALONSO PEA, EULOGIO97625030510/6/984086577211.595923.3231011780.81362.6490310.34131.15512.8697400.41155594100110/17/02828/9/1999, 2/10/1999, 25/10/1999, 13/1/2000, 14/3/2000, 27/10/2000, 19/1/2001, 17/10/20021CA BRONCOGNICO ( 2002)48NO

FUENTES BIELA, GUILLERMO9763226011/5/99359947411.698630.13010821.22461.7751690.83301.35512.3367580.63226610293725/11/1999, 28/12/19990511/2/1997, 30/12/1998, 1/2/1999, 14/9/1999, 19/9/1999829/12/1998, 15/4/1999, 14/6/1999, 9/8/1999, 23/8/1999, 19/9/1999, 5/11/1999, 27/12/19991CA BRONCOGNICO (Enero 2000)12NO

DIARTE ALPUENTE, JESUS9763737238/5/98457306611.757825.525.500751.6512.8471560.73221.6512.8471641.06336682000001CA BRONCOGNICO( Enero 2003)41NO

IGLESIAS ALVAREZ, ANTONIO97643429610/28/975663936511.697927.7282130451.23502.92100420.52181.21493.19110380.4141028694749/5/2002, 4/1/2004, 18/3/2004, 4/5/20040313/4/2002, 28/11/2002, 21/1/2003712/4/2002, 12/2/2003, 14/2/2003, 20/2/2003, 4/1/2004, 18/3/2004, 3/5/20041CA BRONCOGNICO (Junio 2004)80no

MARTINEZ NAVARRO, ROBERTO9762501075/23/973288916411.657226.4261020421.08392.6775410.39121.33483.2192410.3912778395313/12/06021/11/2005, 23/6/2006823/2/2004, 6/10/2005, 31/10/2005, 12/3/2006, 3/6/2006, 7/6/2006, 7/6/2006, 23/6/20061CA BRONCOGNICO ( Julio 2006)112NO

ALADREN VICENTE, FRANCISCO97647350110/29/048547447011.635821.8224150501.15462.8288410.41141.18472.5680460.431541123165185610.249210016/23/0516/23/051CA BRONCOGENICO (Julio 2005)9NO

GAA VISANZAY, FELIX97642791111/19/03558737011.574819.519.511451.03463.18111330.3111.03462.7395380.35135046119149140510.2598613/7/0614/3/0742/9/2004, 29/10/2004, 7/11/2004, 25/9/200667/11/2004, 24/1/2005, 6/3/2006, 9/4/2006, 9/5/2006, 2/4/20071CA BRONCOGNICO ( Abril 2007)41SI

LONGARES BARRANCO, JOSE MARIA9764728238/4/975000227111.625019.1191031361.1463.62116300.43151.06443.35107320.4115604895413/19/02032/9/1997, 30/10/1997, 8/11/200239/5/2000, 18/3/2002, 8/11/20021CA BRONCOGNICO ( Nov 2002)63SI

MADRE BURILLO, JOSE VITORIO9762539118/31/022680286911.739431.43100681.19402.5466470.55181.28432.6970470.6722719595400413/9/2002, 6/11/2002, 26/5/2004, 23/6/200466/11/2002, 26/11/2002, 20/1/2004, 21/5/2004, 23/5/2004, 23/6/20041CA BRONCOGNICO ( Junio 2004)22SI

AMBROJ HERNANDEZ, JESUS9761703012/15/038751387811.675017.9183150800.87362.268400.41161412.1366470.53203366852227/12/2002, 7/2/200300227/12/2002, 7/2/20031CA BRONCOGNICO (Marzo 2004)13SI

MONGE CLAVER, ALEJANDRO9764193525/12/033983425211.75619.4192140400.95292.459400.45121.28382.8971440.671835471011531.72560.22937230/5/2005, 20/2/20070519/6/2005, 16/8/2005, 6/11/2005, 8/8/2006, 6/2/2007818/6/2005, 6/11/2005, 12/12/2005, 9/4/2006, 8/8/2006, 5/9/2006, 11/12/2006, 19/2/20071CA BRONCGNICO ( Febrero 2007)45si

DEL RIO COMIN, PASCUAL9763826429/29/995346096311.655319.519.5470.85312.6876320.35111.02373.0486340.48153434954416/05/2001, 25/08/2001, 26/12/2004, 31/03/20050001CA BRONCOG1NICO (Marzo 2005)66no

GOMEZ GALLEGO, SANTOS9764228422/26/98601256211.758728.42420311401.07332.2454480.47141.18362.868420.4313749494716/1/07225/11/2004, 9/2/2006414/5/2006, 19/9/2006, 7/5/2007, 14/12/2007610/7/2004, 24/11/2004, 18/1/2006, 14/5/2006, 7/5/2007, 1/6/20071CA BRONCOGNICO ( Junio 2007)114si

CRUZ PIERNAGORDA, DOMINGO9762782318/24/049260176111.645018.6193150410.86312.9384290.32101.01363.2593310.39122933124169200610.25965224/7/2005, 17/2/2006033/5/2005, 22/6/2005, 17/1/2006421/1/2005, 23/7/2005, 16/1/2006, 16/2/20061CA BRONCOGNICO (Febrero 2006)18SI

TOMAS ROCHE, JOSE MARIA9762196243/20/984111.594116.2161041521.03332.3362440.45111.11352.4565450.52134965931097/4/2001, 1/11/2001, 24/10/2003, 27/1/2004, 13/2/2004, 19/3/2004, 1/4/2004, 15/4/2004, 17/8/2004013/19/01117/4/2001, 12/5/2001, 31/10/2001, 24/10/2003, 27/1/2004, 12/2/2004, 18/3/2004, 31/3/2004, 15/4/2004, 16/8/2004, 3/9/20041CA BRONCOGNICO ( octubre 2004)79si

AINA BAILO, AURELIO9768300075/9/001677375311.646624.524,54160490.72242.4867290.37100.97323.0783320.47135896100110/5/0501CA BROCOGENICO (noviembre 2006)78SI

ARAGONES GIMENO, JOSE M97643046911/6/002165797311.737424.72530501000.79282.259360.2480.9322.5268360.29105175444/3/2001, 20/4/2001, 5/10/2001, 29/10/20010094/3/2001, 19/4/2001, 5/6/2001, 7/6/2001, 13/8/2001, 23/8/2001, 25/10/2001, 27/10/2001, 29/10/20011CA BRONCOGNICO ( Diciembre 2002)25NO

ARAGON IGLESIAS, BERNARDO97642690011/8/9713255311.66224.2243050370.58202.1962270.2670.68242.0558330.3610263899134174620.26901112/24/9900224/12/1998, 14/1/19991CA BRONCOGENICO (Junio-2000)30SI

FRANCO NAVARRO, JOSE MARIA9764171988/24/984293696511.666724.3242040350.64232.0859310.2480.64232.5372390.31109310083512/10/040419/9/1999, 23/9/2003, 23/11/2003, 5/12/2003422/9/2003, 23/11/2003, 5/12/2003, 9/2/20041CA BRONCOGENICO (Julio 2004)71SI

SD10.20.619.4

gold123

gold256

gold319

gold42

lung cancerby fev post

gold123

gold256

gold319

gold42

stage

%

lung cancer by gold stage

Cancer de pulmon

NombreTfonoFecha PFPHEdadSexoTallaPesobmiIMCDisneaTOSBODFumador activoPaq/aoFEV1L PREFEV1% PREFVCL PREFVC%PREFEV1/FVC PRE25-75 L PRE25-75 % PREFEV1L POSTFEV1% POSTFVCL POSTFVC% POSTFEV1/FVC POST25-75 L POST25-75 % POSTDLCODLCO/VATLC%FRC%RV%RV/TLCIC/TLCSat O2INGRESOSingresos EPOCFECHASINGRESOS cvsFECHASINGRESOS otrosFECHASURGENCIAS POR EPOCFECHASEXITUSCAUSAFECHATIEMPO SEGUIMIENTO (meses)LLAMADO tfnoCOMENTARIOS


AINA BAILO, AURELIO9768300075/9/001677375311.646624.524,54160490.72242.4867290.37100.97323.0783320.47135896100110/5/0501CA BROCOGENICO (noviembre 2006)78SI






ALCAINE PASTOR, JORGE9764277353/5/972832227311.645219.319,310401.16472.578460.43161.41582.8589490.5821739510017/31/00212/5/1999, 17/5/19991CA BRONCOGNICO ( 2002)60SI



CABEZA CABEZA,JOSE M9763972568/16/053816507311.708328.7293020891.66722.4891670.92361.86812.6597701.14449810096126121520.396300310/11/2005, 19/10/2006, 1/3/2007429/11/2005, 27/9/2006, 18/10/2006, 10/2/20071CA BRONCOGNICO ( Abril 2007)4/20/0720NO






ARAGONES GIMENO, JOSE M97643046911/6/002165797311.737424.72530501000.79282.259360.2480.9322.5268360.29105175444/3/2001, 20/4/2001, 5/10/2001, 29/10/20010094/3/2001, 19/4/2001, 5/6/2001, 7/6/2001, 13/8/2001, 23/8/2001, 25/10/2001, 27/10/2001, 29/10/20011CA BRONCOGNICO ( Diciembre 2002)1/10/0225NO

CISNEROS TORRUBIA, LAZARO9764961429/26/973330777511.616424.72500501.78792.5786691381.84822.7793670.84328796787670390.43953019/29/0224/10/1999, 10/1/2004422/9/1999, 16/6/2000, 29/9/2002, 10/1/20041CA BRONCOGNICO ( Enero 2004)1/15/0476SI



MALLO DIAZ, FRANCISCO9763521617/16/044728826911.736020.0202010471.92654.01105480.64212.08704.35114480.752442449730031/9/2004, 27/10/2004, 28/1/2008824/11/2005, 25/11/2005, 22/5/2006, 24/7/2006, 8/8/2006, 11/12/2006, 28/1/2008, 21/2/20081CA BRONCOGNICO ( Febrero 2008)43SI


CABALLERO MERINO, FIDENCIO9763991089/26/003936556611.606224.2242010481.85753.27104570.56191.85753.14100590.6421646596412/3/01110/31/0022/3/2001, 18/7/2003531/10/2000, 3/2/2001, 2/3/2001, 7/7/2001, 17/7/20011CA BRONCOGNICO ( Julio 2001)7/20/0136NO








FRANCO VILLARTE, JACINTO9767326109/29/993255004911.605722.32201642.45824.26119571.19322.5844.09114611.3236554696300315/12/1999, 30/12/1999, 12/1/2000313/10/1999, 30/12/1999, 11/1/20011CA BRONCOGNICO ( Mayo 2000)5/20/0032NO

HERNANDEZ SEBASTIAN, ALBERTO9764338868/9/98266695811.708128.0281100502.52803.7495681.8512.63843.98101661.544492859210013/11/07210/3/2007, 24/5/20071CA BRONCOGNICO ( Mayo 2007)105SI





BERJANO VICENTE, RAMIRO97649624511/3/003892737011.536427.3272110561.38672.2485620.61231.6782.3589680.91341059796214/3/2003018/12/0213/4/031CA BRONCOGENICO ( Octubre 2002)3/4/0329NO





AGUILAR MARTINEZ, MARIANO97635876912/4/014025668211.677225.82600601.07462.0766520.52221.28552.4478520.58244294200225/3/2002, 12/11/2002111/12/021CA BRONCOGENICO (2003)24SI







FUENTES BIELA, GUILLERMO9763226011/5/99359947411.698630.13010821.22461.7751690.83301.35512.3367580.63226610293725/11/1999, 28/12/19990511/2/1997, 30/12/1998, 1/2/1999, 14/9/1999, 19/9/1999829/12/1998, 15/4/1999, 14/6/1999, 9/8/1999, 23/8/1999, 19/9/1999, 5/11/1999, 27/12/19991CA BRONCOGNICO (Enero 2000)1/20/0012NO


BARRIGA GARCIA, BLAS9763913861/3/002269725311.788426.526.51011701.75484.1391420.5131.97544.293470.66178679124163209530.3497400430/1/2006, 17/5/2006, 4/6/2006, 26/6/20061111/10/2001, 12/4/2003, 26/4/2003, 27/4/2006, 28/2/2006, 23/4/2006, 9/5/2006, 16/5/2006, 3/6/2006, 24/6/2006, 25/6/20061CA BRONCOGNICO (Enero 2006)11/14/0672NO



BURRIEL FRANCES, MANUEL9764285768/3/001240026711.646825.3252020511.3502.8284460.39441.39532.3269600.826877794211/14/01012/13/01420/11/2000, 13/1/2001, 27/1/2001, 13/2/20031CA BRONCOGNICO (Febrero 2001)2/2/0130NO





FRANCO NAVARRO, JOSE MARIA9764171988/24/984293696511.666724.3242040350.64232.0859310.2480.64232.5372390.31109310083512/10/040419/9/1999, 23/9/2003, 23/11/2003, 5/12/2003422/9/2003, 23/11/2003, 5/12/2003, 9/2/20041CA BRONCOGENICO (Julio 2004)6/5/0471SI

ALADREN VICENTE, FRANCISCO97647350110/29/048547447011.635821.8224150501.15462.8288410.41141.18472.5680460.431541123165185610.249210016/23/0516/23/051CA BRONCOGENICO (Julio 2005)7/11/059NO


BEZANA MARTIN, ANIANO9763746042/23/993087407211.627026.7270100402.04863.81123540.87312.28954.18134550.9434767095400424/6/1999, 3/9/1999, 4/5/2006, 7/6/200632/9/1997, 3/5/2006, 7/6/20061CA BRONCOGNICO (Junio 2006)6/29/0688NO





CALDERON RONCO, SIMON97634239910/4/002305467311.668229.8302121591.21482.0662590.61221.33522.4373550.53194148961115/4/0376/3/2002, 24/3/2002, 14/6/2002, 24/8/2002, 8/9/2002, 17/12/2002, 14/1/2004311/4/2002, 11/4/2003, 26/3/200484/3/2002, 24/3/2002, 14/6/2002, 24/8/2002, 8/9/2002, 10/4/2003, 4/5/2003, 25/3/20041CA BRONCOGNICO (Marzo 2004)3/29/0441NO

GRACIA ESTEBAN, ENRIQUE9764181806/11/016010816211.607429.0292010902.14833.1496681.21392.34903.4590681.3415253911378/6/2005, 15/12/2005, 20/6/2007, 11/10/2007, 26/12/2007, 20/2/2008, 6/3/200818/10/05522/4/2005, 31/5/2005, 21/6/2005, 9/7/2005, 25/4/20071522/4/2005, 6/6/2005, 9/7/2005, 9/8/2005, 14/12/2005, 10/7/2006, 28/8/2006, 10/5/2007, 17/5/2007, 18/6/2007, 16/7/2007, 11/10/2007, 25/12/2007, 18/2/2008, 6/3/20081CA BRONCOGNICO (Marzo 2008)81SI


ASENSIO BLAZQUEZ, JULIAN9762927083/26/982840826811.595120.2202021701.33562.4380550.55191.59672.6186610.9312833118/31/980001CA BRONCOGNICO (Sept 1999)9/2/9818NO


CALVO GONZALEZ, JOSELUIS9765186301/10/972148125411.667226.1260000242.5813.7198671.47412.64863.5593692.26173669250225/3/1998, 27/4/1998329/9/1997, 9/10/1997, 2/2/199801CA BRONCOGNICO( Abril 1998)4/29/9815NO

CALVO MARTINEZ, JUAN9762167373/24/049070445311.688429.8303131801.4443.1780440.63171.71533.0276571.03287689128168231610.3197618/2/060530/5/2005, 26/6/2005, 15/8/2005, 10/9/2005, 11/7/2006410/9/2005, 10/7/2006, 21/7/2006, 2/8/20061CA BRONCOGNICO( Agosto 2006)8/2/0629NO

DIARTE ALPUENTE, JESUS9763737238/5/98457306611.757825.525.500751.6512.8471560.73221.6512.8471641.06336682000001CA BRONCOGNICO( Enero 2003)1/1/9941NO

CALVO FERNANDEZ, EMILIO97627455610/25/97463437111.726522.0221111501.36483.2888410.44151.48523.1585470.31104848102146132500.23951006/21/02211/6/2002, 21/6/20021CA BRONCOGNICO( Junio 2002)6/21/0254NO


AGON RIVERA, EMILIO9761072733/4/993497977611.665118.518,543130251.07442.268490.68261.28522.5278510.67254594000015/13/991CA PULMON ( Diciembre 1999)9SI

Mean64.21.864.8

SD10.20.619.4

NombreTfonoFecha PFPHEdadSexoTallaPesobmiIMCDisneaTOSBODFumador activoPaq/aoFEV1L PREFEV1% PREFVCL PREFVC%PREFEV1/FVC PRE25-75 L PRE25-75 % PREFEV1L POSTFEV1% POSTFVCL POSTFVC% POSTFEV1/FVC POST25-75 L POST25-75 % POSTDLCODLCO/VATLC%FRC%RV%RV/TLCIC/TLCSat O2INGRESOSingresos EPOCFECHASINGRESOS cvsFECHASINGRESOS otrosFECHASURGENCIAS POR EPOCFECHASEXITUSCAUSAFECHATIEMPO SEGUIMIENTO (meses)LLAMADO tfnoCOMENTARIOS

other cancer

NombreEdadPaq/aoFEV1% PREFEV1% POSTFEV1/FVC POSTCAUSA primaria de muerteFECHACOMENTARIOS

LOPEZ MARIN, GERMAN45208210763NEO DE CARDIAS ( Marzo 2003)

RAMOS RAMOS, EDUARDO563610210669CA CEREBRAL (Julio 2001)

GALLASTEGUI ANADON, MARIANO5233889462MIELOMA MLTIPLE ( Mayo 2001)5/18/01

ONECA ARANA, PABLO7560848755CA DE PRSTATA ( Febrero 2006)

GRACIA TORCAL, FELIPE7352818269NEO RION ( Nov 1998)

BARCA GIL, BENEDICTO6798828066CA VEJIGA (Enero 2000)10/26/04

COLAS BELTRAN, TOMAS6325717766CA ESTMAGO (Julio 2007)8/25/07

BEL ALBIAC, RUDESINDO7325767568LEUCEMIA (2001)

DOMINGO MARTIN, JOAQUIN4850677255hepatocarcinoma, dic-2003consulta en Ambulatorio RyC

CAMARA SANCHO, JESUS7150616856CA PANCREAS ( Octubre 2007)

RUIZ DOMINGO, JOAQUIN6440606865METAS CEREBRALES (Abril 2008)

GRACIA SALDAA, RICARDO75120786757METASTASIS OSEAS ( Junio 2003)

MONTAES ARIO, EMILIO7355756564NEO ANTRO PILRICO ( Enero 2003)

FERNANDEZ CELMA, LUIS5645526460NEO PALADAR ( Nov 1999)11/1/99

GILABERT PASTOR, MANUEL5657536050CA Esofago (Oct-2003)

SOLER CHECA, JOSE6040586043NEO PANCREAS ( Junio 2007)

IRANZO LOU, RAMON7654555943METASTASIS OSEAS ( Febr 2008)

AROSTEGUI AROSTEGUI, JESUS5360575750NEO DE COLON ( Julio 2005)

AZNAR BURRIEL, JOSE LUIS6850435543METATASIS (2004)

ASCASO LAFONTANA, FRANCISCO7425435350CA PLEURA ( Marzo 2006)

VALERO CALVO, BIENVENIDO5460555345CARCINOMA DE VEJIGA

ARTIGAS VAL, FRANCISCO7542445155NEO DE PRSTATA ( 1999)

FRAILE GASCON, CECILIO6937444951CA CEREBRAL (Agosto-2006))

ERLES BENEDICTO, ANTONIO6650424745NEO VEJIGA ( Noviembre 2007)

GORRIZ GAVIN, MARIANO5530414562CA DIGESTIVO ( Octubre 2008)

NEGRO ARTIGAS, ISABEL6347414443METASTAS CEREBRALES ( Mayo 2005)

VICASTILLO LABAT, ANTONIO7036394332CA PROSTATA ( Nov 2001)

BLASCO JACOBO, JULIAN74100354142CA LARINGE (Junio 2008)

DESTRE PUERTOLAS, FELIX5720404148HODKIN ( Mayo 1999)1/30/99

GIMENO GARCIA, FACUNDO8165343933CA VEJIGA (Octubre 2003)

NAVARRO PEREZ, PEDRO5740343644NEO SENO PIRIFORME ( Sept 2007)

GARCIA MUOZ, GINES6442313534NEO DE ESFAGO ( Abril 2006)

DE LA TORRE CRUZ, ESTEBAN64100313434Neoplasia de origen no filiado

GRACIA PASCUAL, ALBERTO6190323439carcinomatosis general (Dic 2006)

RUIZ COELLO, JESUS5230293339CA DE ESTMAGO ( Julio 2004)

VICENTE PEREZ, JUAN JOSE6770273031NEO CEREBELO ( Agosto 2006)

ESCOSA YANGUAS, FRANCISCO5843222738CA ESTMAGO ( Septiembre 2005)

gold 116

gold 243

gold 338

gold 42

other cancer

gold 116

gold 243

gold 338

gold 42

stage

%

cancer non bronchogenic

all cancers by fev post

NombreEdadPaq/aoFEV1% PREFEV1% POSTFEV1/FVC POSTCAUSA primaria de muerteFECHACOMENTARIOS

GRACIA FLETA, JOSE77539910766CA BRONCOGNICO (Febrero 2006)

LOPEZ MARIN, GERMAN45208210763NEO DE CARDIAS ( Marzo 2003)

RAMOS RAMOS, EDUARDO563610210669CA CEREBRAL (Julio 2001)

ORTIN GIMENO, VICENTE495110010469CA BRONCOGNICO ( Julio 2006)

TOVIO ORTEGA, JUAN76609210058CA BRONCOGENICO (Abril 2002)

BEZANA MARTIN, ANIANO7240869555CA BRONCOGNICO (Junio 2006)6/29/06

VINTANED LANGA, RODOLFO5945939567CA BRONCOGENICO (DEC,2008)

GALLASTEGUI ANADON, MARIANO5233889462MIELOMA MLTIPLE ( Mayo 2001)5/18/01

CAMPOS CABAERO, CALIXTO5230919369CA BRONCOGENICO(Septiembre 2006)

LABARTA CUEN, MARIANO7460919166CA BRONCOGNICO ( Enero 2007)

GRACIA ESTEBAN, ENRIQUE6290839068CA BRONCOGNICO (Marzo 2008)

LERIN CAVERO, MIGUEL6175868966CA BRONCOGNICO (Julio 2003)

ONECA ARANA, PABLO7560848755CA DE PRSTATA ( Febrero 2006)

CALVO GONZALEZ, JOSELUIS5424818669CA BRONCOGNICO( Abril 1998)4/29/98

LAHUERTA ROJO, ANTONIO6428788664CA BRONCOGNICO ( Abril 2007)

MARTIN JARAUTA, RODOLFO5134808567CA BRONCOGNICO ( Agosto 2002)

FRANCO VILLARTE, JACINTO4964828461CA BRONCOGNICO ( Mayo 2000)5/20/00

HERNANDEZ SEBASTIAN, ALBERTO5850808466CA BRONCOGNICO ( Mayo 2007)

CISNEROS TORRUBIA, LAZARO7550798267CA BRONCOGNICO ( Enero 2004)1/15/04

GONZALEZ CORREAS, LORENZO7340698250CA BRONCOGENICO ( Marzo 2003)

GRACIA TORCAL, FELIPE7352818269NEO RION ( Nov 1998)

CABEZA CABEZA,JOSE M7389728170CA BRONCOGNICO ( Abril 2007)4/20/07

GIMENO VALERO, RAFAEL6160728161CA BRONCOGNICO (Abril 2008)

BARCA GIL, BENEDICTO6798828066CA VEJIGA (Enero 2000)10/26/04

BUDRIA ABENIA, GREGORIO7490837959CA BRONCOGENICO (Dic-2006)

GRACIA GRANELL, JOSE MIGUEL4941797968CA BRONCOGNICO (Junio 2006)

SALINAS LACAMBRA,JOS4660807969CA BRONCOGNICO ( Sept 2007)

BERJANO VICENTE, RAMIRO7056677868CA BRONCOGENICO ( Octubre 2002)3/4/03

AURE DIESTE, JOSE7875577747CA BRONCOGNICO (Agosto 2007)

COLAS BELTRAN, TOMAS6325717766CA ESTMAGO (Julio 2007)8/25/07

TABUENCA ABADIA, MANUEL6460787759CA BRONCOGNICO ( Marzo 2007)

RUBIO GRANDE, ALEJANDRO4347767664CA BRONCOGNICO ( Enero 2007)

ASENSIO VAL, ALFREDO6087667565CA BRONCOGNICO (2006)

BEL ALBIAC, RUDESINDO7325767568LEUCEMIA (2001)

BURILLO VAL, EDUARDO7358627566CA BRONCOGNICO (Febrero 2001)

CABALLERO MERINO, FIDENCIO6648757559CA BRONCOGNICO ( Julio 2001)7/20/01

MURO VELLOSILLO, JESUS7252737464CA BRONCOGNICO (Enero 2003)

PEREZ RODRIGO, PEDRO56100767474CA BRONCOGNICO ( Febrero2006)

CUBEL BENEDICTO, JULIAN7653757354CA BRONCOGENICO Julio 2004

DOMINGO MARTIN, JOAQUIN4850677255hepatocarcinoma, dic-2003consulta en Ambulatorio RyC

PALACIOS CASADO, PILAR4940707160CA BRONCOGNICO ( Marzo 2003)

MALLO DIAZ, FRANCISCO6947657048CA BRONCOGNICO ( Febrero 2008)

BELLO GIL, LORENZO5525656857CA BRONCOGENICO (Marzo 2003)

BELTRAN CARBO, RAFAEL6170566845CA BRONCO.+METAS (Febrero 2002)

CAMARA SANCHO, JESUS7150616856CA PANCREAS ( Octubre 2007)

RUIZ DOMINGO, JOAQUIN6440606865METAS CEREBRALES (Abril 2008)

ASENSIO BLAZQUEZ, JULIAN6870566761CA BRONCOGNICO (Sept 1999)9/2/98

GRACIA SALDAA, RICARDO75120786757METASTASIS OSEAS ( Junio 2003)

MARTINEZ SIMON, JOSELUIS3422576752CA BRONCOGNICO ( Noviembre 2007)

BETES PALOMO, CARLOS5339636649CA BRONCOGNICO (Mayo 2007)

MUOZ GREGORIO, JOSE6343556656CA BRONCOGNICO ( Abril 2005)

AZNAR ABANSES, ROBERTO5763616549CA BRONCOGNICO ( Agosto 2007)

MONTAES ARIO, EMILIO7355756564NEO ANTRO PILRICO ( Enero 2003)

NADAL BINTANED, PEDRO7650576552CA BRONCOGNICO (Enero 2007)

CASAOLA MOREN, JORGE7945596458CA BRONCOGNICO (Abril 2004)

FERNANDEZ CELMA, LUIS5645526460NEO PALADAR ( Nov 1999)11/1/99

GILABERT PASTOR, MANUEL5657536050CA Esofago (Oct-2003)

MARTIN MORENO, SEVERIANO6980576044CA BRONCOGNICO ( Octubre 2003)

SOLER CHECA, JOSE6040586043NEO PANCREAS ( Junio 2007)

ANCHELERGUES MURILLO, EDUARDO6650585954CA BRONCOGNICO ( 12 Abril 2008)

GASCON MANERO, RODOLFO6930605964CA BRONCOGNICO ( Agosto 2001)

IRANZO LOU, RAMON7654555943METASTASIS OSEAS ( Febr 2008)

PERNA PERNA, LUIS7340505940CA BRONCOGENICO ( Noviembre 2006)

AROSTEGUI AROSTEGUI, JESUS5360575750NEO DE COLON ( Julio 2005)

FERNANDEZ TORRIJOS, JESUS7347505752CA BRONCOGNICO ( Octubre 2004)

MAINAR LUO, MAXIMO6840515747CA BRONBOGNICO ( Mayo 2005)

AZNAR BURRIEL, JOSE LUIS6850435543METATASIS (2004)

BARRIGA GARCIA, BLAS5370485447CA BRONCOGNICO (Enero 2006)11/14/06

DE DIOS EXPOSITO, AGAPITO6540545456CA BRONCOGNICO (Febrero 2003)

ASCASO LAFONTANA, FRANCISCO7425435350CA PLEURA ( Marzo 2006)

BURRIEL FRANCES, MANUEL6751505360CA BRONCOGNICO (Febrero 2001)2/2/01

CALVO MARTINEZ, JUAN5380445357CA BRONCOGNICO( Agosto 2006)8/2/06

VALERO CALVO, BIENVENIDO5460555345CARCINOMA DE VEJIGA

CALDERON RONCO, SIMON7359485255CA BRONCOGNICO (Marzo 2004)3/29/04

CALVO FERNANDEZ, EMILIO7150485247CA BRONCOGNICO( Junio 2002)6/21/02

MOLINE POLO, SAGRARIO6330525258CA BRONCOGNICO ( Nov 2006)

ALONSO PEA, EULOGIO7278365140CA BRONCOGNICO ( 2002)2002

ARTIGAS VAL, FRANCISCO7542445155NEO DE PRSTATA ( 1999)

DIARTE ALPUENTE, JESUS6675515164CA BRONCOGNICO( Enero 2003)1/1/99

FUENTES BIELA, GUILLERMO7482465158CA BRONCOGNICO (Enero 2000)1/20/00

FRAILE GASCON, CECILIO6937444951CA CEREBRAL (Agosto-2006))

IGLESIAS ALVAREZ, ANTONIO6545504938CA BRONCOGNICO (Junio 2004)

MARTINEZ NAVARRO, ROBERTO6442394841CA BRONCOGNICO ( Julio 2006)

ERLES BENEDICTO, ANTONIO6650424745NEO VEJIGA ( Noviembre 2007)

GAA VISANZAY, FELIX7045464638CA BRONCOGNICO ( Abril 2007)

GORRIZ GAVIN, MARIANO5530414562CA DIGESTIVO ( Octubre 2008)

LONGARES BARRANCO, JOSE MARIA7136464432CA BRONCOGNICO ( Nov 2002)

NEGRO ARTIGAS, ISABEL6347414443METASTAS CEREBRALES ( Mayo 2005)

MADRE BURILLO, JOSE VITORIO6968404347CA BRONCOGNICO ( Junio 2004)

VICASTILLO LABAT, ANTONIO7036394332CA PROSTATA ( Nov 2001)

AMBROJ HERNANDEZ, JESUS7880364147CA BRONCOGNICO (Marzo 2004)

BLASCO JACOBO, JULIAN74100354142CA LARINGE (Junio 2008)

DESTRE PUERTOLAS, FELIX5720404148HODKIN ( Mayo 1999)1/30/99

GIMENO GARCIA, FACUNDO8165343933CA VEJIGA (Octubre 2003)

MONGE CLAVER, ALEJANDRO5240293844CA BRONCGNICO ( Febrero 2007)

DEL RIO COMIN, PASCUAL6347313734CA BRONCOG1NICO (Marzo 2005)

CRUZ PIERNAGORDA, DOMINGO6141313631CA BRONCOGNICO (Febrero 2006)

GOMEZ GALLEGO, SANTOS62140333642CA BRONCOGNICO ( Junio 2007)

NAVARRO PEREZ, PEDRO5740343644NEO SENO PIRIFORME ( Sept 2007)

GARCIA MUOZ, GINES6442313534NEO DE ESFAGO ( Abril 2006)

TOMAS ROCHE, JOSE MARIA4152333545CA BRONCOGNICO ( octubre 2004)

DE LA TORRE CRUZ, ESTEBAN64100313434Neoplasia de origen no filiado

GRACIA PASCUAL, ALBERTO6190323439carcinomatosis general (Dic 2006)

RUIZ COELLO, JESUS5230293339CA DE ESTMAGO ( Julio 2004)

ARAGONES GIMENO, JOSE M73100283236CA BRONCOGNICO ( Diciembre 2002)1/10/02

VICENTE PEREZ, JUAN JOSE6770273031NEO CEREBELO ( Agosto 2006)

ESCOSA YANGUAS, FRANCISCO5843222738CA ESTMAGO ( Septiembre 2005)

ARAGON IGLESIAS, BERNARDO5337202433CA BRONCOGENICO (Junio-2000)

FRANCO NAVARRO, JOSE MARIA6535232339CA BRONCOGENICO (Julio 2004)6/5/04

gold1gold 2gold 3gold 4

26.4%61.6%28.6%3.3%

totals2456263

gold126.4

gold261.6

gold328.6

gold43.3

all cancers by fev post

26.4

61.6

28.6

3.3

GOLD STAGES post BD

(%)

all cancers

all cancers

NombreTfonoFecha PFPHEdadSexoTallaPesobmiIMCDisneaTOSBODFumador activoPaq/aoFEV1L PREFEV1% PREFVCL PREFVC%PREFEV1/FVC PRE25-75 L PRE25-75 % PREFEV1L POSTFEV1% POSTFVCL POSTFVC% POSTFEV1/FVC POST25-75 L POST25-75 % POSTDLCODLCO/VATLC%FRC%RV%RV/TLCIC/TLCSat O2INGRESOSingresos EPOCFECHASINGRESOS cvsFECHAS ingresos CVSINGRESOS otrosFECHAS otras causas de ingresoURGENCIAS POR EPOCFECHAS de asistencia en urgencias por ExEPOCEXITUSCAUSA primaria de muerteFECHATIEMPO SEGUIMIENTO (meses)LLAMADO tfnoCOMENTARIOS





ARAGONES GIMENO, JOSE M97643046911/6/002165797311.737424.72530501000.79282.259360.2480.9322.5268360.29105175444/3/2001, 20/4/2001, 5/10/2001, 29/10/20010094/3/2001, 19/4/2001, 5/6/2001, 7/6/2001, 13/8/2001, 23/8/2001, 25/10/2001, 27/10/2001, 29/10/20011CA BRONCOGNICO ( Diciembre 2002)1/10/0225NO

AROSTEGUI AROSTEGUI, JESUS97649502511/6/971107605311.579036.536.52030601.55573.1595490.58171.54573.1194500.7201001069250051/10/2002, 3/11/2002, 12/5/2003, 27/5/2003, 14/7/200361/2/1999, 30/9/2002, 23/11/2002, 19/4/2003, 6/5/2003, 14/7/20031NEO DE COLON ( Julio 2005)100SI

ARTIGAS VAL, FRANCISCO9768310522/18/985042887511.484219.2193030420.75441.4465520.39170.87511.5971550.371650749510014/26/9801NEO DE PRSTATA ( 1999)12SI

ASCASO LAFONTANA, FRANCISCO9764215181/25/052590797411.584718.8192130250.93432.278420.33131.14532.2680500.5622437496200211/2/2005, 28/2/200601CA PLEURA ( Marzo 2006)14SI

ASENSIO BLAZQUEZ, JULIAN9762927083/26/982840826811.595120.2202021701.33562.4380550.55191.59672.6186610.9312833118/31/980001CA BRONCOGNICO (Sept 1999)9/2/9818NO




AZNAR BURRIEL, JOSE LUIS9762749455/6/975848626811.778928.4281010501.35433.278420.46141.73554.06100430.515877391000012/5/021METATASIS (2004)84SI

BARCA GIL, BENEDICTO97635412212/16/981471516711.567731.6320101981.86822.7595681.05371.81802.7595660.91327783101108118490.3689400411/9/2002, 19/5/2004, 9/8/2004, 26/10/2004916/6/2000, 20/6/2001, 16/8/2002, 26/8/2002, 28/8/2002, 11/9/2002, 15/7/2004, 20/7/2004, 25/10/20051CA VEJIGA (Enero 2000)10/26/0484NO

BARRIGA GARCIA, BLAS9763913861/3/002269725311.788426.526.51011701.75484.1391420.5131.97544.293470.66178679124163209530.3497400430/1/2006, 17/5/2006, 4/6/2006, 26/6/20061111/10/2001, 12/4/2003, 26/4/2003, 27/4/2006, 28/2/2006, 23/4/2006, 9/5/2006, 16/5/2006, 3/6/2006, 24/6/2006, 25/6/20061CA BRONCOGNICO (Enero 2006)11/14/0672NO

BEL ALBIAC, RUDESINDO97663121310/13/986858927311.5874.529.8301000251.66762.4185690.98371.64752.4184680.9335698287107121550.3510010/4/999/10/991LEUCEMIA (2001)36SI



BERJANO VICENTE, RAMIRO97649624511/3/003892737011.536427.3272110561.38672.2485620.61231.6782.3589680.91341059796214/3/2003018/12/0213/4/031CA BRONCOGENICO ( Octubre 2002)3/4/0329NO


BEZANA MARTIN, ANIANO9763746042/23/993087407211.627026.7270100402.04863.81123540.87312.28954.18134550.9434767095400424/6/1999, 3/9/1999, 4/5/2006, 7/6/200632/9/1997, 3/5/2006, 7/6/20061CA BRONCOGNICO (Junio 2006)6/29/0688NO

BLASCO JACOBO, JULIAN97643245310/1/984734057411.698028.028111000.92351.9958460.29101.09412.675420.3115058102153169670.1792423/9/1999, 3/1/2002027/10/2004, 1/11/200463/9/1999, 8/10/2001, 3/1/2002, 31/3/2003, 27/3/2004, 27/8/20041CA LARINGE (Junio 2008)106SI



BURRIEL FRANCES, MANUEL9764285768/3/001240026711.646825.3252020511.3502.8284460.39441.39532.3269600.826877794211/14/01012/13/01420/11/2000, 13/1/2001, 27/1/2001, 13/2/20031CA BRONCOGNICO (Febrero 2001)2/2/0130NO

CABALLERO MERINO, FIDENCIO9763991089/26/003936556611.606224.2242010481.85753.27104570.56191.85753.14100590.6421646596412/3/01110/31/0022/3/2001, 18/7/2003531/10/2000, 3/2/2001, 2/3/2001, 7/7/2001, 17/7/20011CA BRONCOGNICO ( Julio 2001)7/20/0136NO

CABEZA CABEZA,JOSE M9763972568/16/053816507311.708328.7293020891.66722.4891670.92361.86812.6597701.14449810096126121520.396300310/11/2005, 19/10/2006, 1/3/2007429/11/2005, 27/9/2006, 18/10/2006, 10/2/20071CA BRONCOGNICO ( Abril 2007)4/20/0720NO

CALDERON RONCO, SIMON97634239910/4/002305467311.668229.8302121591.21482.0662590.61221.33522.4373550.53194148961115/4/0376/3/2002, 24/3/2002, 14/6/2002, 24/8/2002, 8/9/2002, 17/12/2002, 14/1/2004311/4/2002, 11/4/2003, 26/3/200484/3/2002, 24/3/2002, 14/6/2002, 24/8/2002, 8/9/2002, 10/4/2003, 4/5/2003, 25/3/20041CA BRONCOGNICO (Marzo 2004)3/29/0441NO

CALVO FERNANDEZ, EMILIO97627455610/25/97463437111.726522.0221111501.36483.2888410.44151.48523.1585470.31104848102146132500.23951006/21/02211/6/2002, 21/6/20021CA BRONCOGNICO( Junio 2002)6/21/0254NO

CALVO GONZALEZ, JOSELUIS9765186301/10/972148125411.667226.1260000242.5813.7198671.47412.64863.5593692.26173669250225/3/1998, 27/4/1998329/9/1997, 9/10/1997, 2/2/199801CA BRONCOGNICO( Abril 1998)4/29/9815NO

CALVO MARTINEZ, JUAN9762167373/24/049070445311.688429.8303131801.4443.1780440.63171.71533.0276571.03287689128168231610.3197618/2/060530/5/2005, 26/6/2005, 15/8/2005, 10/9/2005, 11/7/2006410/9/2005, 10/7/2006, 21/7/2006, 2/8/20061CA BRONCOGNICO( Agosto 2006)8/2/0629NO

CAMARA SANCHO, JESUS9762703504/19/056592017111.649133.8341000501.52612.6582570.59211.71682.0594560.66237484104117142560.439710016/1/07521/2/2006, 4/1/2007, 29/1/2007, 8/4/2007, 31/5/20071CA PANCREAS ( Octubre 2007)30SI



CISNEROS TORRUBIA, LAZARO9764961429/26/973330777511.616424.72500501.78792.5786691381.84822.7793670.84328796787670390.43953019/29/0224/10/1999, 10/1/2004422/9/1999, 16/6/2000, 29/9/2002, 10/1/20041CA BRONCOGNICO ( Enero 2004)1/15/0476SI

COLAS BELTRAN, TOMAS9764187692/21/06395856311.758628.1280000252.28713.6288631.25372.46773.7391661.4142717992200224/3/2007, 25/8/2007323/3/2007, 12/7/2007, 25/8/20071CA ESTMAGO (Julio 2007)8/25/0718NO




DE LA TORRE CRUZ, ESTEBAN97643888510/10/007703306411.574317.4171000.74312.1772340.33110.82342.3979340.3101421945013/11/0531Neoplasia de origen no filiado87no


DESTRE PUERTOLAS, FELIX97657386012/28/984443045711.677828.0281020201.2402.6470460.52151.26412.6169480.491457869710014/11/9914/11/991HODKIN ( Mayo 1999)1/30/995SI

DIARTE ALPUENTE, JESUS9763737238/5/98457306611.757825.525.500751.6512.8471560.73221.6512.8471641.06336682000001CA BRONCOGNICO( Enero 2003)1/1/9941NO

DOMINGO MARTIN, JOAQUIN9764286945/20/002617824811.636926.02600502.09673.8100551.04272.25724.06107550.93256257129143192490.491300321/11/2000, 24/11/2000, 16/9/200349/12/2000, 21/2/2003, 10/3/2003, 16/9/20031hepatocarcinoma, dic-200342noconsulta en Ambulatorio RyC

ERLES BENEDICTO, ANTONIO97649122510/13/042090536611.638933.533.52030501.09422.4273450.33111.22472.6881450.4135764118159195650.249310019/5/07630/1/2007, 31/5/2007, 20/6/2007, 6/7/2007, 11/7/2007, 5/9/20071NEO VEJIGA ( Noviembre 2007)37SI

ESCOSA YANGUAS, FRANCISCO9763902663/19/983452245811.667828.32801430.66222.0254330.3390.81272.1458380.339376692400425/12/1999, 19/7/2001, 4/2/2003, 30/6/200472/2/1999, 20/10/1999, 22/12/1999, 23/12/1999, 24/12/1999, 19/7/2001, 30/6/20041CA ESTMAGO ( Septiembre 2005)90NO

FERNANDEZ CELMA, LUIS9764117175/24/974785395611.565522.6232121451.34522.4176560.58171.67642.888600.92763759410519/1/1999, 7/4/1999, 5/7/1999, 29/8/1999, 8/11/199911/7/98411/9/1997, 28/4/1998, 7/1/1999, 16/8/1999419/1/1999, 10/5/1999, 4/7/1999, 29/8/19991NEO PALADAR ( Nov 1999)11/1/9930NO


FRAILE GASCON, CECILIO97642155812/27/022974796911.648431.2312030371.12442.2668490.62211.25492.4574510.57207290100123152620.397216/9/06015/2/0675/6/2005, 9/10/2005, 21/11/2005, 21/4/2006, 2/5/2006, 3/6/2006, 9/6/20061CA CEREBRAL (Agosto-2006))44si

FRANCO NAVARRO, JOSE MARIA9764171988/24/984293696511.666724.3242040350.64232.0859310.2480.64232.5372390.31109310083512/10/040419/9/1999, 23/9/2003, 23/11/2003, 5/12/2003422/9/2003, 23/11/2003, 5/12/2003, 9/2/20041CA BRONCOGENICO (Julio 2004)6/5/0471SI

FRANCO VILLARTE, JACINTO9767326109/29/993255004911.605722.32201642.45824.26119571.19322.5844.09114611.3236554696300315/12/1999, 30/12/1999, 12/1/2000313/10/1999, 30/12/1999, 11/1/20011CA BRONCOGNICO ( Mayo 2000)5/20/0032NO

FUENTES BIELA, GUILLERMO9763226011/5/99359947411.698630.13010821.22461.7751690.83301.35512.3367580.63226610293725/11/1999, 28/12/19990511/2/1997, 30/12/1998, 1/2/1999, 14/9/1999, 19/9/1999829/12/1998, 15/4/1999, 14/6/1999, 9/8/1999, 23/8/1999, 19/9/1999, 5/11/1999, 27/12/19991CA BRONCOGNICO (Enero 2000)1/20/0012NO

GALLASTEGUI ANADON, MARIANO9765945083/18/994948375211.659033.1330001332.72884.34114631.58432.92944.72124621.541886170075/4/1999, 18/5/1999, 23/9/1999, 15/9/2000, 16/1/2001, 30/1/2001, 19/3/20011118/5/1999, 16/7/1999, 5/12/1999, 18/12/1999, 22/12/1999, 19/3/2000, 27/6/2000, 13/1/2000, 16/1/2001, 29/1/2001, 18/3/20011MIELOMA MLTIPLE ( Mayo 2001)5/18/0126NO


GARCIA MUOZ, GINES9763789285/10/044016356411.737123.7242140420.95313.0477310.34101.09353.281340.37114050115162192610.2695100112/30/05112/29/051NEO DE ESFAGO ( Abril 2006)23SI


GILABERT PASTOR, MANUEL9464284285/23/986687645611.626725.525.53031571.53533.2191480.75221.7603.3896500.672092849610019/30/0319/30/031CA Esofago (Oct-2003)65si

GIMENO GARCIA, FACUNDO9764275916/14/023840498111.628130.9314150650.71342.2779310.24100.84392.5789330.3137078136202214720.1394214/22/030110/14/03621/4/2003, 29/6/2003, 12/7/2003, 11/10/2003, 13/10/2003, 14/10/20031CA VEJIGA (Octubre 2003)16SI




GORRIZ GAVIN, MARIANO9764925377/19/042000555511.646524.22411301.22411.9854620.55161.33452.1358620.72204663132186273730.249310011/9/0854/9/2006, 11/9/2006, 25/7/2007, 18/12/2007, 6/10/20081CA DIGESTIVO ( Octubre 2008)51NO

GRACIA ESTEBAN, ENRIQUE9764181806/11/016010816211.607429.0292010902.14833.1496681.21392.34903.4590681.3415253911378/6/2005, 15/12/2005, 20/6/2007, 11/10/2007, 26/12/2007, 20/2/2008, 6/3/200818/10/05522/4/2005, 31/5/2005, 21/6/2005, 9/7/2005, 25/4/20071522/4/2005, 6/6/2005, 9/7/2005, 9/8/2005, 14/12/2005, 10/7/2006, 28/8/2006, 10/5/2007, 17/5/2007, 18/6/2007, 16/7/2007, 11/10/2007, 25/12/2007, 18/2/2008, 6/3/20081CA BRONCOGNICO (Marzo 2008)81SI



GRACIA PASCUAL, ALBERTO97637865511/5/038454306111.555522.9232041900.77321.8461420.2890.81342.0669390.31103352963317/7/2004, 15/9/2004, 1/11/200600617/7/2004, 14/9/2004, 4/10/2006, 13/10/2006, 15/10/2006, 29/10/20061carcinomatosis general (Dic 2006)36si

GRACIA SALDAA, RICARDO97653065512/19/974298317511.729331.431111201.79782.8378630.84301.82673.1988570.6523596389101104470.389320026/10/1999, 18/10/199942/8/1999, 7/8/1999, 17/10/1999, 7/3/20011METASTASIS OSEAS ( Junio 2003)66SI

GRACIA TORCAL, FELIPE9762758151/21/98257187311.726722.6232111522.26813.3391681.25432.29823.3191691.3847394596417/28/980323/3/1998, 11/9/1998, 5/11/1998111/5/981NEO RION ( Nov 1998)129SI

HERNANDEZ SEBASTIAN, ALBERTO9764338868/9/98266695811.708128.0281100502.52803.7495681.8512.63843.98101661.544492859210013/11/07210/3/2007, 24/5/20071CA BRONCOGNICO ( Mayo 2007)105SI


IRANZO LOU, RAMON97649582711/21/02793077611.678229.4292120541.36553.0492450.38141.48593.47105430.52197267128171191620.2597600625/6/2003, 24/2/2004, 7/5/2004, 12/1/2005, 4/4/2005, 17/11/200747/5/2004, 5/9/2004, 16/11/2007, 7/1/20081METASTASIS OSEAS ( Febr 2008)63SI





LOPEZ MARIN, GERMAN9762766229/9/99680884511.686824.1242011202.82824.76115591.69423.681075.82140632.25568159148153237490.4740046/8/2002, 21/1/2003, 6/2/2003, 2/3/2003511/6/2001, 24/4/2002, 2/6/2002, 5/8/2002, 2/3/20031NEO DE CARDIAS ( Marzo 2003)42SI



MALLO DIAZ, FRANCISCO9763521617/16/044728826911.736020.0202010471.92654.01105480.64212.08704.35114480.752442449730031/9/2004, 27/10/2004, 28/1/2008824/11/2005, 25/11/2005, 22/5/2006, 24/7/2006, 8/8/2006, 11/12/2006, 28/1/2008, 21/2/20081CA BRONCOGNICO ( Febrero 2008)43SI







MONTAES ARIO, EMILIO97641939710/22/984410497311.586024.0244030551.63752.587650.84321.7652.5588640.933243589316/25/020215/11/2002, 23/12/2002517/3/2000, 14/7/2000, 24/6/2002, 14/11/2002, 22/12/20021NEO ANTRO PILRICO ( Enero 2003)51SI




NAVARRO PEREZ, PEDRO97641156011/18/031748825711.715318.1182141401.1342.6366420.44121.14362.665440.43124875928510/10/2006, 21/11/2006, 15/1/2007, 14/4/2007, 6/7/20070329/8/2004, 30/7/2007, 11/8/20071428/8/2004, 29/1/2005, 1/3/2006, 3/3/2006, 8/3/2006, 13/3/2006, 9/10/2006, 19/11/2006, 13/1/2007, 11/4/2007, 28/6/2007, 28/6/2007, 6/7/2007, 11/8/20071NEO SENO PIRIFORME ( Sept 2007)46SI

NEGRO ARTIGAS, ISABEL97637815211/2/013656956301.546929.1292131470.77411.7878440.38140.84441.9585430.3714487691215/15/07014/27/07325/3/2007, 27/4/2007, 15/5/20071METASTAS CEREBRALES ( Mayo 2005)42SI

ONECA ARANA, PABLO9764210841/14/043333397511.697325.6260000602.19844.16121530.72262.27874.14120550.8129232189212/8/06012/9/05910/9/2004, 12/9/2004, 30/11/2004, 31/1/2005, 7/2/2005, 26/4/2005, 23/8/2001, 25/8/2005, 7/2/20061CA DE PRSTATA ( Febrero 2006)25SI





RAMOS RAMOS, EDUARDO9762776649/29/99264495611.618432.4320001361.871024.35125661.46432.971064.29124691.87551209996300330/10/2000, 12/12/2000, 18/1/2001230/10/2000, 17/1/20011CA CEREBRAL (Julio 2001)22SI


RUIZ COELLO, JESUS9765212942/12/972231875211.657025.7264060300.9292.5367360.2771.03332.6670390.29890100931013/21/97017/9/041CA DE ESTMAGO ( Julio 2004)89SI

RUIZ DOMINGO, JOAQUIN97642356110/17/965059036411.647327.1272110401.62602.4972650.96311.84682.8382650.9631115121946210/5/2005, 24/3/2008045/4/2000, 18/4/2000, 12/5/2000, 24/2/2001529/10/1999, 9/5/2005, 12/8/2007, 15/8/2007, 24/3/20081METAS CEREBRALES (Abril 2008)138SI


SOLER CHECA, JOSE97629749412/21/991618376011.716020.520.501401.81583.96100460.71211.87604.33110430.621855539830034/7/2006, 20/8/2006, 30/8/200661/1/2000, 12/2/2002, 25/7/2005, 4/7/2006, 12/1/2007, 15/2/20071NEO PANCREAS ( Junio 2007)90NO




VALERO CALVO, BIENVENIDO9760695804/10/063041605411.635821.8220111601.61553.5798450.59171.57533.4896450.631849461141461540.396200226/3/07,2/7/0801CARCINOMA DE VEJIGA29SI

VICASTILLO LABAT, ANTONIO9764407087/4/97826007011.627528.62900360.96393.0797310.3111.05433.28104320.33125257941112/11/0100111/11/011CA PROSTATA ( Nov 2001)53SI

VICENTE PEREZ, JUAN JOSE9764396492/26/995030896711.788727.527.500700.86272.9170290.2370.96303.0974310.39729998147160590.2295214/28/02012/14/06825/8/1999, 19/6/2001, 2/7/2001, 11/2/2002, 28/4/2002, 26/3/2003, 31/1/2006, 13/2/20061NEO CEREBELO ( Agosto 2006)92SI


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lung cancer and copd the two sides of the coin

Documents

lung inflammation

majo j

n engl j med

eur respir j

j respir crit care med

lung tissuecd8 inflammation

development of lung

development of copd