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can also be isolated from barley and wheat lunasin content:

-increase during seed maturation-decrease during sprouting with soaking time.

Some genotypes contain:

- very high concentrations of lunasin, others containno lunasin, and some locations yield more lunasin-richbeans than others

a small subunit of the 2S albumin fraction of soy and thisfraction has been shown in a study to not cause anyallergic reaction in people with sensitivity to soy

heat stable; surviving and retaining its activity even after 10

min of boiling a key component in soy protein responsible for its

cholesterol-lowering properties. exhibits health promoting characteristics.

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Lunasin works in two ways to lower serumLDL cholesterol levels:

1. it selectively disrupts a necessary step

in the production of a key enzyme,HMG-CoA reductase. With levels ofthe HMG-CoA reductase enzymelowered and available for the liver to

carry out cholesterol synthesis, theliver in turn produces less cholesterol.

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http://www.lunasin.com/Portals/0/poster_lg.jpg

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http://www.lunasin.com/Portals/0/poster_lg.jpghttp://www.lunasin.com/Portals/0/poster_lg.jpg

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Lunasin & Cancer Soybeans also contain bioactive proteins that exhibit anticancer activity

including lectins and the most recently discovered peptide lunasin.

By its involvement in allowing or denying access to genes for transcription,acetylation is pivotal in the process of turning genes on and off.

Lunasin has a binding affinity for regions of nucleosomes that are not fullyacetylated. The negatively charged amino acids of Lunasin have a naturalattraction to positively charged amino acid in histones. During acetylation,the positive charge on histones is neutralized. When this occurs, genesinvolved in cell proliferation (e.g. oncogenes) are "turned on" or activated,resulting in tumors or cancer. Lunasin can bind to hypoacetylated histones(histones that still have the positive charge) in different regions ofchromosomes, blocking or preventing their acetylation. This blocking actionhelps keep cancer related genes switched "off".

The chromatin binding affinity of Lunasin is believed to the underlying

mechanism responsible for the cancer-preventing property of Lunasin. Aseries of studies strongly suggests that chromatin modification is linked withtumor suppression pathways. When delivered to the proper target tissueLunasin may play a role in preventing or "silencing" the expression of genesthat lead to tumor formation, intervening primarily at the initiation andpromotion-and possibly other stages of carcinogenesis.

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Lunasin & Cancer was first investigated as a factor that might prevent cancer cells from dividing

and multiplying a key sequence of amino acids--arginine, glycine, and aspartic acid, (the RGD

motif)--that triggered the death of leukemia cells by activating a protein calledcaspase-3

scientists have noted the cancer-preventive effects of the RGD sequence ofamino acids so it's important to find proteins that have this sequence

lunasin's ability to inhibit topoisomerase 2, an enzyme that marks the

development of cancer, and they were able to quantify the number of leukemiacells that were killed after treatment with lunasin in laboratory experiments

In another study, the first to report lunasin's potential anti-inflammatory activity,showed that lunasin blocked or reduced the activation of an important markercalled NF-kappa-B, a link in the chain of biochemical events that causeinflammation. Thus, they concluded that daily consumption of lunasin-rich soyprotein may help to reduce chronic inflammation.

lunasin induces cell death in highly metastatic human colon cancer cells lunasin can penetrate the cancer cell, cause cell death, and interact with at

least one type of receptor in a cell that is ready to metastasize. When thatreceptor is blocked, new blood vessels can't form and differentiate, and thatprevents cancer from spreading. Binding such receptors has emerged as apromising target for developing cancer therapies

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ReferencesHernndez-Ledesma, Blanca and de Lumen, Ben O. Lunasin: A Novel Cancer

Preventive Seed Peptide. Perspect Medicin Chem. 2008; 2: 7580.

Lunasin. Accessed 11 May 2012. Retrieved from

Combination of lunasin and oxaliplatin prevents colon cancer frommetastasis Published on September 20, 2011 at 6:02 AM. Accessed 12 May2012. Retrieved from

Soy Peptide Lunasin Has Anti-Cancer, Anti-Inflammatory Properties.ScienceDaily (Dec. 2, 2009) Accessed 11 May 2012. Retrieved from

http://www.lunasin.com/ScientificResearch.aspxhttp://www.lunasin.com/ScientificResearch.aspxhttp://www.lunasin.com/ScientificResearch.aspxhttp://www.lunasin.com/ScientificResearch.aspxhttp://www.news-medical.net/news/20110920/Combination-of-lunasin-and-oxaliplatin-prevents-colon-cancer-from-metastasis.aspx?page=2http://www.news-medical.net/news/20110920/Combination-of-lunasin-and-oxaliplatin-prevents-colon-cancer-from-metastasis.aspx?page=2http://www.news-medical.net/news/20110920/Combination-of-lunasin-and-oxaliplatin-prevents-colon-cancer-from-metastasis.aspx?page=2http://www.news-medical.net/news/20110920/Combination-of-lunasin-and-oxaliplatin-prevents-colon-cancer-from-metastasis.aspx?page=2http://www.news-medical.net/news/20110920/Combination-of-lunasin-and-oxaliplatin-prevents-colon-cancer-from-metastasis.aspx?page=2http://www.sciencedaily.com/releases/2009/12/091202153946.htmhttp://www.sciencedaily.com/releases/2009/12/091202153946.htmhttp://www.sciencedaily.com/releases/2009/12/091202153946.htmhttp://www.news-medical.net/news/20110920/Combination-of-lunasin-and-oxaliplatin-prevents-colon-cancer-from-metastasis.aspx?page=2http://www.sciencedaily.com/releases/2009/12/091202153946.htmhttp://www.news-medical.net/news/20110920/Combination-of-lunasin-and-oxaliplatin-prevents-colon-cancer-from-metastasis.aspx?page=2http://www.news-medical.net/news/20110920/Combination-of-lunasin-and-oxaliplatin-prevents-colon-cancer-from-metastasis.aspx?page=2http://www.news-medical.net/news/20110920/Combination-of-lunasin-and-oxaliplatin-prevents-colon-cancer-from-metastasis.aspx?page=2http://www.news-medical.net/news/20110920/Combination-of-lunasin-and-oxaliplatin-prevents-colon-cancer-from-metastasis.aspx?page=2http://www.news-medical.net/news/20110920/Combination-of-lunasin-and-oxaliplatin-prevents-colon-cancer-from-metastasis.aspx?page=2http://www.news-medical.net/news/20110920/Combination-of-lunasin-and-oxaliplatin-prevents-colon-cancer-from-metastasis.aspx?page=2http://www.news-medical.net/news/20110920/Combination-of-lunasin-and-oxaliplatin-prevents-colon-cancer-from-metastasis.aspx?page=2http://www.news-medical.net/news/20110920/Combination-of-lunasin-and-oxaliplatin-prevents-colon-cancer-from-metastasis.aspx?page=2http://www.news-medical.net/news/20110920/Combination-of-lunasin-and-oxaliplatin-prevents-colon-cancer-from-metastasis.aspx?page=2http://www.news-medical.net/news/20110920/Combination-of-lunasin-and-oxaliplatin-prevents-colon-cancer-from-metastasis.aspx?page=2http://www.news-medical.net/news/20110920/Combination-of-lunasin-and-oxaliplatin-prevents-colon-cancer-from-metastasis.aspx?page=2http://www.news-medical.net/news/20110920/Combination-of-lunasin-and-oxaliplatin-prevents-colon-cancer-from-metastasis.aspx?page=2http://www.news-medical.net/news/20110920/Combination-of-lunasin-and-oxaliplatin-prevents-colon-cancer-from-metastasis.aspx?page=2http://www.news-medical.net/news/20110920/Combination-of-lunasin-and-oxaliplatin-prevents-colon-cancer-from-metastasis.aspx?page=2http://www.news-medical.net/news/20110920/Combination-of-lunasin-and-oxaliplatin-prevents-colon-cancer-from-metastasis.aspx?page=2http://www.news-medical.net/news/20110920/Combination-of-lunasin-and-oxaliplatin-prevents-colon-cancer-from-metastasis.aspx?page=2http://www.news-medical.net/news/20110920/Combination-of-lunasin-and-oxaliplatin-prevents-colon-cancer-from-metastasis.aspx?page=2http://www.news-medical.net/news/20110920/Combination-of-lunasin-and-oxaliplatin-prevents-colon-cancer-from-metastasis.aspx?page=2http://www.news-medical.net/news/20110920/Combination-of-lunasin-and-oxaliplatin-prevents-colon-cancer-from-metastasis.aspx?page=2http://www.news-medical.net/news/20110920/Combination-of-lunasin-and-oxaliplatin-prevents-colon-cancer-from-metastasis.aspx?page=2http://www.news-medical.net/news/20110920/Combination-of-lunasin-and-oxaliplatin-prevents-colon-cancer-from-metastasis.aspx?page=2http://www.lunasin.com/ScientificResearch.aspx