8/10/2019 Lrig Alsb Terrywood

1/23

Gu5095.1

Terry Wood

Pfizer Global Research & DevelopmentSandwich, UK

An Automated Approachto the Supply of Samples

for Screening

8/10/2019 Lrig Alsb Terrywood

2/23

Gu5095.2

AutomatedLiquid

SampleBank

A secure storefor >2.5 million

samples capable

of delivering

daughter plates

on demand

8/10/2019 Lrig Alsb Terrywood

3/23

Gu5095.3

Project Plan

The System

Deliverables

Future

8/10/2019 Lrig Alsb Terrywood

4/23

Gu5095.4

The Numbers Challenge

0

n

2n

3n

4n

5n

6n

Year

Compounds

Tested

1997 1998 1999 2000 2001 2002 2003 2004 2005

8/10/2019 Lrig Alsb Terrywood

5/23

Gu5095.5

best return oninvestmentstability

less time per hit

Faster

8/10/2019 Lrig Alsb Terrywood

6/23

Gu5095.6

Return on Investment

Aggregated

Cost($ millions)

Year

0

1997 1998 1999 2000 2001 2002 2003 2004 2005

2

4

6

8

10

12

14

ALSB

Manual+ staff increase

16

0

8/10/2019 Lrig Alsb Terrywood

7/23

Gu5095.7

FAT -Factory Acceptance Test

Milestones

PINT - Pfizer Integration

SAT - Site Acceptance Test

8/10/2019 Lrig Alsb Terrywood

8/23

Gu5095.8

Factory Acceptance Test

8/10/2019 Lrig Alsb Terrywood

9/23

Gu5095.9

FAT -Factory Acceptance Test

Milestones

SAT - Site Acceptance Test

PINT - Pfizer Integration

8/10/2019 Lrig Alsb Terrywood

10/23

Gu5095.10

Site Acceptance Test

Administrator Form Operation Functionality of all GUI forms that allow the

administrator to set orders.

Administrator Transactions Testing of all sample withdrawal, replacement

and replenishment capabilities described in the

specification.

Daughter Plate Orders Ensure the system delivers all permissible

variations of daughter plate format.

Access Procedures The various elements within the ALSB must be

accessible, but only when the system is in a safe

condition.

Replenishment of Consumable Items Demonstration that al l consumable storage

modules are accessible, operable and give

suitable alerts when running low.

Alarm Conditions and Recovery from Failure Simulation of a wide range of hardware, software

and service failures, to demonstrate that the

equipment fails safe and the system is

recoverable.

Performance Testing Does the system delivers its output within the

time frames specified.

Administrator Form Operation Functionality of all GUI forms that allow the administrator to setorders.

Administrator Transactions Testing of all sample withdrawal, replacement and replenishmentcapabilities described in the specification.

Daughter Plate Orders Ensure the system delivers all permissible variations of daughterplate format.

Access Procedures The various elements within the ALSB must be accessible, but onlywhen the system is in a safe condition.

Replenishment of Demonstration that all consumable storage modules are accessible,Consumable Items operable and give suitable alerts when running low.

Alarms and Recovery Simulation of a wide range of hardware, software and service from

Failure failures, to demonstrate that the equipment fails safe and the system is recoverable.

Performance Testing Does the system delivers its output within the time frames specified.

8/10/2019 Lrig Alsb Terrywood

11/23

Gu5095.11

FAT -Factory Acceptance Test

Milestones

SAT - Site Acceptance Test

PINT - Pfizer Integration

8/10/2019 Lrig Alsb Terrywood

12/23

Gu5095.12

Pfizer Integration Testing

8/10/2019 Lrig Alsb Terrywood

13/23

Gu5095.13

Legacy Sample Transfer

Plate Based Tube Based

+ Tube I.d.

+ Tube Septum

+ Volume

8/10/2019 Lrig Alsb Terrywood

14/23

Gu5095.14

Cold Store

Defrost Station

Conveyor System

Liquid

Handling

Cells

The Technical Solution

Customers

600 plates/24hrs

OR

6000 single/24hrs

Robot arm

Robotic Carousel

Key

Robotic SampleProcessor

up to 1000+

assay plates/24hrs

8/10/2019 Lrig Alsb Terrywood

15/23

Gu5095.15

Cold

Store

Gantry

Robotics

8/10/2019 Lrig Alsb Terrywood

16/23

Gu5095.16

Defrost Oven Feeder Robot

8/10/2019 Lrig Alsb Terrywood

17/23

Gu5095.17

Liquid Handling Cell

8/10/2019 Lrig Alsb Terrywood

18/23

Gu5095.18

Then ...

8/10/2019 Lrig Alsb Terrywood

19/23

Gu5095.19

.. Now

8/10/2019 Lrig Alsb Terrywood

20/23

Gu5095.20

Lessons Learnt

Marketing

Buy - inEnhancements

2onot 1o

8/10/2019 Lrig Alsb Terrywood

21/23

Project buy-in

8/10/2019 Lrig Alsb Terrywood

22/23

Cold Store Cold Store Extension

Defrost Station

Conveyor System

Conveyor System Extension

AdvancedRSPs

Future development

Total Automation System

Customers

LiquidHandling

Cells

8/10/2019 Lrig Alsb Terrywood

23/23

Gu5095.23