MILESTONEH E L P I N GP A T I E N T S

LOGOS JThe right tool for the lean lab

The fi rst “personal” hybrid tissue processor

Quality. Speed. Flexibility. Automation.

LOGOS J as...

The processor that did not exist.But was needed.Milestone has matched the unarticulated needs of users with technological possibilities that open new doors.

The LOGOS J is the resultof a philosophy that setsa new standard in the fi eldof tissue processing.

LOGOS J as...

... a fully automatedbone marrow

processor for turnaround time in less

than 24 hours.

... a dedicated,optimized rapid

tissueprocessor for specific

specimens:prostate, skin,

gastric, ...

... a dedicatedrapid tissue

processor for stat, urgent or

transplant biopsies,for results within50-60 minutes.

... a rapid, flexible,tissue processor for

biopsies (up to 3mm)to level-out the work

load in the lab.

... an optimized conventional

resistance heated processor for HER-2,

ER, PgR according to ASCO and CAP

guidelines.

... your application

?

The challenge: improving the workfl ow of the laboratory.

Faster than conventional processing

The LOGOS J rack consists of 48 cassettes to allow the fl exibility to fi t any workload requirements.(Optional: 2 segments of 21 cassettes each)

From 1 up to 48 cassettes

LOGOS J processes biopsies with specifi c optimized protocols to consistently assure the highest standard of quality.

Colonic biopsy, microwave processed

H&E (x 400)

Breast cells HER2 amplifi cation detection

by IHC. Hematoxylin counterstain (x 400)

Bowel biopsy, microwave processed. Alcian blue microwave staining (x

400)

Breast cells HER2 amplifi cation detection

by FISH processed by microwaves (x 800).

Unmatched processing fl exibility

Unmatched processing times

Unmatched quality

In today’s histology labs, the workload consists approximately of 35-50% small biopsies (below 3 mm) and 40-50% surgical specimens. Transplant, stat and urgent biopsies that require a rapid turnaround time are a minority of the total workload. This small number of biopsies interferes with the routine workfl ow of the laboratory. Large capacity conventional tissue processors do not fulfi ll the requirements for the speed and fl exibility needed to eff ectively improve the workfl ow of a laboratory or address these specifi c workfl ow streams.

Note: The above timing are referred to ethanol/isopropanol protocols, excluding reagent movement.

Specimenthickness

Rapid protocols.Fully automated

Improved workfl ow with sequential processing in continuous batch mode

Transplant(less than 1mm)

Full batch processed in 36 minutes(including fi xation) Batch loading every 21 minutes

1 mm(i.e. GI/Endoscopic byopsies)

Full batch processed in 1 h 16 minutes(including fi xation) Batch loading every 51 minutes

3 mm Full batch processed in 3 h 28 minutes(including fi xation) Batch loading every 2 hours 13 minutes

Implementation of the “lean” lab requires optimized dedicated instrumentation. The LOGOS J fulfi lls this requirement and addresses the unmet need for a benchtop, compact, fl exible load, rapid tissue processor. This new tool incorporates an innovative solution to solve workfl ow problems in histology laboratories.

LOGOS J . The right tool for the “lean” lab.

Night Operation.Fully automated, bone marrow processor for a diagnosis in less than 24 hours

During the night, or if required during the day, LOGOS J will process bone marrow specimens through the fi xation, decalcifi cation, dehydration clearing and impregnation steps in a fully automated mode. The specimens will be ready for cutting, embedding and staining to allow rapid diagnosis in less than 24-hour.

Day Operation (1). Urgent specimens.As a fully automated, single retort, rapid hybrid tissue processor

During the day the histotech will start dedicated single batch runs with short cleaning cycles. LOGOS J will run urgent biopsies with hybrid microwave technology as a fully automated unit.Molten wax will be transferred automatically to and from the processing retort for impregnation.

Day Operation (2). Higher throughput.As a sequential, dual retort, simultaneous batch hybrid tissue processor

1 The fi rst rack is processed in the fi xation/dehydration/clearing processing retort

2 At the end of the cycle, therack is manually transferredto the wax retort

3 A new rack is placed in the processing retort.The two racks are simultaneously processed.

Processingretort

Processingretort

Waxretort

Waxretort

Processingretort

Waxretort

An events log lists all activities carried out with the unit for documentation, service and quality assurance purposes.

5The complete summary of the new protocol is displayed for approval or modification before starting the process.

4

Administrator can easily setup a new protocol by selecting through the multiple choices available for each step.

3

Intuitive touch display.

2 Icon-driven. User friendly.

Enter the appropriate user level.The administrator can modify programs or store new ones.The operator can recall and run existing processing protocols.

1

LOGOS J. Software like never before.We could not make it more intuitive.

Milestone world market leadership

Largest installed base of microwave tissue processors

Over 1,600 units in operation worldwide

The “de facto” standard in rapid processing

Lowest cost of ownership

The highest quality of application and service support

Microwave retort Wax retort Easy, safe transfer of exhausted wax

through heated PTFE connector

Touch-screen, icon-driven control terminal

Up to 10 quick disconnect 2 l reagent tanks

Heated, PTFE coated, internal surface to avoid condensation

of reagents for consistent processing. Enhanced operator safety by elimination of vapors

LOGOS J. Green, safe and economical.Packed with the latest technologyfor an improved work environment.

Open system. No proprietary

reagents commitments.

Use of histology grade wax.

CAT330-002

In your country:MILESTONE Srl - Via Fatebenefratelli, 1/5 - 24010 Sorisole (BG) - ItalyTel: +39 035 4128264 - Fax: +39 035 575498www.milestonemedsrl.com - email: medical@milestonesrl.com

MILESTONE MEDICAL TECHNOLOGIES, INC.6475 Technology Avenue, Suite F, Kalamazoo, MI 49009 - USATel: 269-488-4950 - Toll-free: 866-995-5300 - Fax: 269-488-4949www.milestonemed.com - email: info@milestonemed.com

UNI EN ISO 9001: 2008 / UNI EN ISO 13485:2012 CERTIFIED

MILESTONE

H E L P I N GP A T I E N T S

LOGOS J.

Hours, not days!

Total processing time (fi xation to impregnation) for bone marrow specimens of 1.8 mm diameter(11 gauge)

For the fi st time fully automated fi xation (formalin), decalcifi cation (formic acid, EDTA), dehydration, clearing and impregnation of bone marrow samples can be carried out in less than 24 hours.

Decalcifi er Temperature Time

Formic acid 10% 37°C 4h 11’

Formic acid 10% 50°C 3h 16’

EDTA 10% 37°C 20h 41’

EDTA 10% 50°C 5h 46’

Bone marrow, EDTA, H&E x 100

Fully automated bone marrow processingfor a diagnosis in less than 24-hours.

Note: The above timing are referred to ethanol/isopropanol protocols, excluding reagent movement.