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estancia La Jolla Hotel9700 North Torrey Pines Rd.La Jolla, CA 920371-858-550-10001-877-4-ESTANCIA(toll free reservations)858-550-1001 (fax)www.Estancialajolla.com

Hotel Reservation Deadline: May 28, 2019.The site for the meeting is on 9.5 acres in the enchanting seasidecommunity of La Jolla. The Estancia La Jolla Hotel is located inthe midst of a classic California coastal rancho setting, adjacent toworld-class Torrey Pines Golf Course, and just minutes from theSan Diego Zoo, Sea World, shopping and beautiful SouthernCalifornia beaches. The Estancia La Jolla Hotel is only 14 milesfrom downtown San Diego and Lindbergh Field (San DiegoInternational Airport). A limited number of rooms have beenreserved for course participants and will be reserved as requestsare received.

Reservation Deadline: May 28, 2019 If your reservation is notreceived prior to cut-off date, reservations will be accepted subjectto availability. Please specify that you plan to attend the 25thAnnual SAN DIEGO HEART FAILURE SYMPOSIUM soyou can receive our special course rate.

HoteL ratesSpecial room rates are offered: Single or Double - $255 per nightplus current San Diego occupancy tax of 12.5%, $15 hospitality fee and $15 overnight parking fee. First night’s deposit or credit card guarantee must accompany reservation.For Reservations call the hotel directly: 1-877-4-ESTANCIA

he 25th Annual San Diego Heart Failure Symposium celebrates the‘Silver’ Anniversary of the largest heart failure meeting in the region.

This year’s program is designed to specifically focus on the latest and mostexciting advances in the management of heart failure through a series of didac-tic lectures, case presentations and debates. Topics that will be covered extendfrom preventing heart failure by managing risk factors such as hypertension,diabetes and hyperlipidemia to treating heart failure throughout all its stages.Key areas that will be covered include management of sleep disordered breath-ing, use of biomarkers, treatment of pulmonary artery hypertension, new usesof DOACs, HFpEF, management of atrial fibrillation, prevention of suddendeath and integration of both older and newer heart failure drugs into the ther-apeutic regimen. The Symposium also covers use of percutaneous mechanicalcirculatory support and LVADs, heart transplantation as well as new treatmentoptions for amyloid cardiomyopathy. There will be in-depth discussion aboutthe rationale for and practical aspects of using new drugs for treating activationof the renin angiotensin system, slowing heart rate and managing hyperkalemia.In addition to the formal presentations, we have expanded opportunities forinteractive discussions between the speakers and the audience in the program.This year, the 5th Annual Stanley Lloyd M.D. lecture will be presented by Dr.Mandeep Mehra, who will visit from Boston where he is a Professor at theBrigham and Women’s Hospital and Harvard Medical School. Lisa Salzberg,the Executive Director of the Hypertrophic Cardiomyopathy Association andDr. Clyde Yancy from Northwestern University will also join the faculty. Bypopular demand, ‘The Great Debate’ will return with Drs. Greenberg andFonarow meeting once again to examine whether digoxin still has a role in themanagement of heart failure patients.

SYMPOSIUM OBJECTIVESAt the conclusion of this program, the participant should be able to:1. Summarize current and emerging treatments for heart failure, describe new guideline updates and provide practical information to help in the implementation of recommended therapies in individual patients.2. Review strategies for implementing medical and device therapies that will enhance prevention and lead to improved outcomes in heart failure patients.

3. Define how specific populations including minorities, women and the elderly respond to various approaches to treating hypertension and heart failure.

TARGET AUDIENCEThe target audience for this activity includes cardiologists, internists, primarycare physicians, nurses and allied healthcare professionals.

tLoCation Course desCription, oBJeCtiVes & CMe inforMation

NEEDS ASSESSMENTHeart failure (HF) is common, affecting nearly 5 million Americans. It is alsoone of the few cardiovascular disorders for which prevalence figures areincreasing. An estimated 670,000 new cases of HF are diagnosed each year andthis condition is a major cause of morbidity and mortality (80% of men and70% of women less than 65 years of age who have HF will die within 8 years).Overall, heart failure is the number one cause of hospitalizations of the elderlyin the U.S. Knowledge about HF is accumulating rapidly. To help individual clinicianssynthesize new information and integrate new approaches into effective strate-gies of care for patients with this syndrome. The Symposium will provide acomprehensive overview of diagnostic approaches, current evidence-basedtherapies and treatment strategies as well as emerging approaches for treatment.ACCREDITATIONThis live activity, 25th Annual San Diego Heart Failure Symposium, with abeginning date of 06/28/2019, has been reviewed and is acceptable for up to 11.5Prescribed credit(s) by the American Academy of Family Physicians. Physiciansshould claim only the credit commensurate with the extent of their participationin the activity.AAFP Prescribed credit is accepted by the American Medical Association asequivalent to AMA PRA Category 1 Credit™ toward the AMA Physician'sRecognition Award.AANP: The American Academy of Nurse Practitioners accepts AAFPPrescribed credit. This program was planned in accordance with AANP CEStandards and Policies and AANP Commercial Support Standards.ANCC: According to the ANCC, the continuing education hours approved bythe AAFP meet the ANCC-accredited CNE criteria.AAPA: The American Academy of Physician Assistants accepts AAFPPrescribed credit for AAPA Category 1 CME credit.CULTURAL AND LINGUISTIC COMPENTENCYThis activity is in compliance with California Assembly Bill 1195 which requires continuingmedical education activities with patient care components to include curriculum in the subjectsof cultural and linguistic competency. Cultural competency is defined as a set of integrated atti-tudes, knowledge, and skills that enables health care professionals or organizations to careeffectively for patients from diverse cultures, groups, and communities. Linguistic competencyis defined as the ability of a physician or surgeon to provide patients who do not speak Englishor who have limited ability to speak English, direct communication in the patient’s primary lan-guage. Cultural and linguistic competency was incorporated into the planning of this activity.

SYMPOSIUM CANCELLATIONSIf your registration must be cancelled and a refund of your fee is desired, yourfee, less $50 for administrative costs, will be refunded upon receipt of a writtenrequest that includes your signature. No refunds will be made after May 15,2019. Please allow up to 12 weeks for a refund.FURTHER INFORMATION Complete Conference Management3320 Third Avenue, Suite CSan Diego, CA 92103

PH 619-299-6673 FAX 619-299-6675info@ccmmeetings.comwww.ccmmeetings.com

http://cardiology.ucsd.edu

SYMPOSIUM LOCATIONEstancia La Jolla Hotel9700 North Torrey Pines RoadLa Jolla, CA 92037858-550-10001-877-4-ESTANCIA (toll free reservations)858-550-1001 (fax)www.Estancialajolla.comHotel Reservation Deadline: May 28, 2019

Register for theSymposiumOnline at:

ccmmeetings.com

Ulrika Birgersdotter-Green,MDProfessor of MedicineDivision of CardiologyDirector, Pacemaker and ICD Services

Daniel Blanchard, MD,FACC Professor of Clinical MedicineDirector, Cardiology FellowshipProgramUCSD Sulpizio Cardiovascular Center

Lori Daniels, MD, MAS,FACC, FAHAProfessor of Medicine Director, Cardiovascular Intensive Care UnitUCSD Div. of Cardiovascular Medicine

Jonathan Hsu, MD, MASAssociate ProfessorSection of Cardiac Electrophysiology Division of Cardiology

Trina Huynh, PharmD, BCPSPharmacist, Transitions ofCare CoordinatorDepartment of Pharmacy

Paul Kim, MDAssistant Clinical Professor of MedicineDivision of Cardiology

Atul Malhotra, MDProfessor of MedicineResearch Chief Pulmonary, Critical Care and Sleep Medicine

Paul J. Mills, PhDProfessor and Chief, Family Medicine and Public Health

Anya Narezkina, MDProfessor and Chief, Assistant Professor of Medicine

Demosthenes G.Papamatheakis, MDAssociate Clinical Professor of MedicineDivision of Pulmonary, Critical Care and Sleep Medicine

Gert Victor Pretorius, MBchBAssociate Clinical Professor of SurgerySurgical Director, Heart Transplant &Mechanical Assist ProgramDiv. of Cardiovascular & Thoracic Surgery

Ryan Reeves, MD Assistant Professor of MedicineInterventional Cardiology

Jia Shen, MD, MPHAssistant Clinical Professor of MedicineDepartment of Cardiovascular Diseases

Pam R. Taub, MD, FACCAssociate Professor of MedicineDirector of Hannah and Gene StepCardiac Wellness & Rehabilitation CenterDivision of Cardiovascular Medicine

Howie Tran, MD, FACCAssistant Professor of MedicineDivision of Cardiovascular Medicine

Marcus Anthony Urey, MDAssistant Clinical Professor of MedicineDivision of Cardiovascular Medicine

uC san dieGo proGraM direCtor

FACULTY DISCLOSUREIt is our policy to ensure balance, independence, objectivity and scientific rigor. All persons involved in the selec-tion, development and presentation of content are required to disclose any real or apparent conflicts of interest.All conflicts of interest will be resolved prior to an educational activity being delivered to learners through oneof the following mechanisms 1) altering the financial relationship with the commercial interest, 2) altering theindividual’s control over CME content about the products or services of the commercial interest, and/or 3) vali-dating the activity content through independent peer review. All persons are also required to disclose any discus-sions of off label/unapproved uses of drugs or devices. Persons who refuse or fail to disclose will be disqualifiedfrom participating in the CME activity.

First Name ___________________________________________________

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Title ________________________________________________________

Office Address _______________________________________________

City _____________________________State ______Zip ____________

Phone ____________________________Fax________________________

Email________________________________________________________

Professional Specialty __________________________________________

Special Needs for Disabled _____________________________________REGISTRATION FEES Early Bird Reg. Pre-Reg Registration

on or before April 27- on or after April 26, 2019 May 27, 2019 May 28, 2019

Physician $130 $160 $190

Nurse & Allied Health Care $110 $130 $160Students with Student ID* $60 $60 $60 *with letter from Department Supervisor

RSVP REQUIRED FOR THESE EVENTS (included with registration)Friday (PLEASE ENROLL EARLY, SPACE IS VERY LIMITED)q Friday Sessions I & II - 1:00m-6:00pmSaturdayq Optional Breakfast Session - 7:00am-8:00am (non-CME)q Optional Lunch Session - 12:10-1:20pm (non-CME)

CREDIT CARD PAYMENT (Visa, Mastercard, Am Ex or Discover)Name _______________________________________________________ Card Number _________________________________________________

Exp. Date __________________ Security Code ___________________Name on Card ________________________________________________Billing Address ____________________________________________________________________________________________________________ Amount $ ____________________________________________________ Signature ____________________________________________________

Register Online: ccmmeetings.comCHECK OR MONEYORDER PAYMENT(in US dollars) Make payable to:UC Regents

MAIL OR FAX TO:Complete Conference Management3320 Third Avenue, Suite CSan Diego, CA 92103Fax: 619-299-6675

f a C u L t Y p r o G r a M

GUEST FACULTYBrian Carlos, MDAdvanced Heart FailureDepartment of CardiologySouthern California PermanenteMedical GroupSan Diego, CA

John Chin, MD, FACC,FHFSAProfessor of Medicine, CaliforniaNorthstate University College ofMedicineMedical Director Advanced HeartFailure & Cardiac Transplant ServicesSutter Medical CenterSacramento, CA

Salvatore Di Somma, MD,PhDProfessor of MedicineDirector Emergency MedicineChairman Postgraduate School ofEmergency MedicineDepartment of Medical-SurgerySciences and Translational MedicineUniversity La Sapienza RomeSant’Andrea HospitalPresident GREAT Network ItalyRome, Italy

Uri Elkayam, MD, FACCProfessor of MedicineDivision of CardiologyUniversity of Southern CaliforniaLos Angeles, CA

Gregg Fonarow, MD, FACC, FAHA, FHFSAEliot Corday Professor inCardiovascular Medicine and ScienceDirector, Ahmanson – UCLACardiomyopathy CenterCo-Director, UCLA PreventativeCardiology ProgramCo-Chief of Clinical Cardiology,UCLA Division of CardiologyDavid Geffen School of Medicine Los Angeles, CA

Mandeep R. Mehra, MD,FACC, FESC, FHFSA, FRCP(London)The William Harvey Distinguished Chair inAdvanced Cardiovascular MedicineExecutive Director, Center forAdvanced Heart DiseaseProfessor of Medicine, Harvard Medical SchoolEditor in Chief, The Journal of Heartand Lung TransplantationBrigham and Women’s HospitalBoston, MA

Lisa SalbergFounder & CEOHypertrophic CardiomyopathyAssociationDenville, NJ

Clyde W. Yancy, MD, MScVice Dean, Diversity & InclusionMagerstadt Professor of MedicineProfessor of Medical Social SciencesChief, Division of CardiologyNorthwestern University, FeinbergSchool of MedicineChicago, IL

UC SAN DIEGO PARTICIPATING FACULTYR E G I S T R AT I O NRegister Online: ccmmeetings.com

Barry H. Greenberg, MD, FACCDistinguished Professor of MedicineDirector, Advanced Heart Failure Treatment ProgramUCSD Medical CenterSan Diego, CA

San Diego Heart Failure Symposium 2019FRIDAY, JUNE 28, 201912:15-1:00pm Registration - Pacifica Ballroom FoyerSESSION I: STRATEGIES FOR PREVENTING CARDIOVASCULAR DISEASEBarry Greenberg, MD - Moderator1:00-1:05 Welcome/Introduction to the 25th Annual Syposium Barry Greenberg, MD1:05-1:25 Managing Blood Pressure: New Goals and How to Best Achieve Them - Daniel Blanchard, MD 1:25-1:45 What’s New in Treating Hyperlipidemia: Update on PCSK9 Inhibition and Treating Hypertriglyceridemia - Pam Taub, MD1:45-2:05 Treating Diabetes with SGLT2 Inhibitors to Reduce Cardiovascular Disease - Gregg Fonarow, MD2:05-2:25 Disordered Breathing: Who Should be Treated and How to Do It - Atul Malhotra, MD2:25-2:45 Cardiac Rehabilitation for Heart Failure Patients - Pam Taub, MD2:45-3:20 Case Vignettes/Q and A - Barry Greenberg, MD (Moderator)

Drs. Blanchard, Taub, Fonarow, Malhotra, and Trina Huynh, Pharm D (Panelists)3:20-3:40 Break/Visit ExhibitsSESSION II: ADVANCES IN MANAGING RISK FACTORS AND TREATING HEART FAILURE - Pam Taub, MD - Moderator3:40-4:00 The Wearable Revolution: Treating Patients at Arm’s Length Jia Shen, MD4:00-4:20 Can Thinking Positively and Expressing Gratitude Reduce Cardiovascular Risk? - Paul Mills, PhD4:20-4:40 HFpEF: How Can We Best Treat It? - Barry Greenberg, MD4:40-5:00 Recognizing and Treating Pulmonary Arterial Hypertension (PAH)

Demos Papamatheakis, MD5:00-5:20 Natriuretic Peptides, ST2 and hsTn: How Can Biomarkers Help Us Manage HF Patients? - Lori Daniels, MD5:20-5:40 Hyponatremia: Causes, Implications and Treatments Uri Elkayam, MD5:40-6:00 Q/A Session - Pam Taub, MD (Moderator) Drs. Elkayam, Greenberg, Mills, Papmatheakis, Daniels and Trina Huynh Pharm D (Panelists) 6:00 Adjourn Day 1SATURDAY, JUNE 29, 20196:30-8:00am Registration/Exhibits/Sessions - La Jolla Ballroom7:00-8:00am Industry Breakfast Symposium - Pacifica Ballroom - (Non-CME)8:05-8:10am Welcome and Introductions - La Jolla Ballroom

Barry Greenberg, MD - Program DirectorSESSION I: ADVANCES IN HEART FAILURE MANAGEMENT STRATEGIESBarry Greenberg, MD - Moderator8:10-8:30 Recognizing Disparities in Healthcare in the U.S. and Finding Solutions - Clyde Yancy, MD8:30-8:50 Integrating ARNIs and Other Novel Medical Therapies Into the Medical Regimen to Improve Outcomes - Gregg Fonarow, MD

8:50-9:10 Managing Hyperkalemia: Potential Impact on Use of RAAS Inhibitors Barry Greenberg, MD

9:10-9:30 Using Hydralazine and Nitrates to Treat Heart Failure Uri Elkayam, MD

SATURDAY, JUNE 29, 2019 (continued)9:30-9:50 FEATURED INTERNATIONAL HEART FAILURE LECTURE Unraveling the Secrets of Longevity and Low CV Risk in Southern Italy Salvatore Di Somma, MD9:50-10:10 Discussion and Q/A

Barry Greenberg, MD (Moderator), Drs. Fonarow, Yancy, Di Somma & Elkayam (Discussants)

10:10-10:35 Coffee Break/Visit ExhibitsSESSION II: ADVANCES IN HEART FAILURE THERAPYMarcus Anthony Urey - Moderator10:35-10:55 Percutaneous Mechanical Support: Which Setting/Which Device? Ryan Reeves, MD10:55-11:20 State of the Art: Cardiac Transplantation in 2019 Gert Victor Pretorius, MBchB 11:20-12:10 Special Seminar on the Recognition and Treatment of Amyloidosis Introduction and Overview: Marcus Anthony Urey, MD (5 min) AL Amyloidosis and Treatment: Anya Narezkina MD (5 min) ATTR Amyloidosis: Marcus Anthony Urey MD (5 min) Detection Using Ultrasound and Other Cardiac Imaging: Paul Kim MD (5 min) Neurologic Involvement of AL and ATTR Amyloidosis: Marcus Anthony Urey MD (5 min) Case Presentation/Panel Discussion/Q&A: Focus on Novel Treatments for ATTR Amyloidosis (25 min) Drs. Urey, Narezkina and Kim 12:10-1:20 Lunch - Pacifica BallroomSESSION III: ADVANCES IN HEART FAILURE MANAGEMENTBarry Greenberg - Moderator 1:20-1:50 5th ANNUAL STANLEY LLOYD, MD LECTURE Mechanical Circulatory Support for the Failing Heart: Past, Present and Future - Mandeep Mehra, MD1:50-2:10 Hypertrophic Cardiomyopathy - Lisa Salberg2:10-2:35 Panel Discussion and Audience Q/A - Barry Greenberg, MD (Moderator)

Drs. Mehra, Yancy, Pretorius and Lisa Salberg (Panelists)2:35-2:55 Break/Visit ExhibitsSESSION IV: CONTROVERSIES IN HEART FAILURE - Howie Tran, MD - Moderator2:55-3:15 Managing Patients with Atrial Fibrillation: Rate vs Rhythm Control and Use of LA Devices to Prevent Embolic Complications - Jonathan Hsu, MD3:15-3:40 The Great Debate-Year 2: Dig is Useful in Treating HF Patients

Moderator-Howie Tran, MD Pro - Barry Greenberg, MD Con - Gregg Fonarow, MD Rebuttals - Drs Greenberg and Fonarow Audience Questions and Vote to Determine the Winner

3:40-4:00 Preventing Sudden Cardiac Death with ICDs and WCDUlrika Birgersdotter-Green, MD

4:00-4:20 Update on DOAC’s: New Uses/New Indications - John Chin, MD Drs. Birgersdotter Green, Fonarow and Maisel (Panelists)4:20-4:40 Remote Monitoring of Heart Failure Patients: What We’ve Learned About Patient Selection and Optimizing Therapies - Howie Tran, MD 4:40-5:00 Case Presentation/Final Q&A - Brian Carlos, MD (Presenter) Drs. Greenberg, Fonarow, Birgersdotter-Green, Chin & Tran (Panelists)5:00 Adjourn until June, 2020 for the 26th San Diego Heart Failure Symposium