local anesthesia - nnoha · trivia: the dental local anesthesia industry combined now serves up 330...
TRANSCRIPT
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“30+ Years of Hits, Misses and Near MiSs-
es”
THE NATIONAL NETWORK for ORAL HEALTH ACCESS
THE 2015 ANNUAL CONFERENCE Indianapolis, Indiana November 16th , 2015
Mel Hawkins, DDS, BScD AN Dentist / Dentist Anesthesiologist
Toronto, ON Canada
Sedation & Anesthesia in Dental Practice
LOCAL ANESTHESIA:
www.sedationdentistry.us [email protected]
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1 2 3
Anatomy, Blocks, Road
Blocks, More
Blocks
What’s new? Paresthesia,
reversing, buffering,
inhalational and more
AGENDA
What can go wrong and what
to do about it?
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ANATOMY, BLOCKS, ROAD BLOCKS AND MORE BLOCKS
PART
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THE ELUSIVE McDibular BLOCK
…millions and millions served . . .
Trivia: The dental local anesthesia industry combined now serves up 330 million cartridges every year in North America
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A=86%
B=7%
C=7%
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Inferior Alveolar Block
“Conventional” as opposed to a
“mandibular block”
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Relationship of:
Conventional (inferior alveolar)
Akinosi, closed mouth
Gow-Gates “condylar neck”
Hybrid, “mix and match” blocks
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Anatomical Variations:
• Hard tissue anatomy
• Connective tissue and Neurovascular anatomy
Reasons for Failure
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Dr. George Gow-Gates, Dr. J. Watson, University of Sydney, Australia
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• Internal Oblique Ridge •Sphenomandibular fascial barrier
•Risks: Nerves, Arteries
3 Major Factors:
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The distance between the internal and external oblique line of the mandible varies. Adapted from Dr. N. B. Jorgensen
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Netter, Grant’s Anatomy
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Anatomical Influences:
The maxillary artery, passes through the high
pterygomandibular triangle region
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The Question is:
What is the risk of an intraarterial injection?
Clinically Unlikely
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Characteristics: • Thick smooth muscle wall • Well innervated • Constricts or arteriospasms, eliminates
lumen • Artery is mobile within the anatomical
area • Pulse pressure
Internal Maxillary Artery
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True Confessions
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Histology
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Horizontal X-S, level of Conventional I.A.N.Block
Courtesy Dr. G. A. E. Gow-Gates, Dr. J. Watson
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Horizontal X-S, level of Gow-Gates Mandibular Block
Courtesy Dr. G. A. E. Gow-Gates, Dr. J. Watson
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Conventional Advantages
• Intra-oral landmark for 110 years
• Practitioner acceptance for 110 years
• Fast onset if accurate and no neural aberrance, as in grade B and C anesthesia problems (14%)
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Conventional Disadvantages
• Increased vascularity • Anatomical variance • Macroglossia • Paresthesia mechanical -
lingual claims experience X2 • (Long) buccal nerve “block”
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Syndrome:
“The Chin on the
Chest”
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Rx Open the Airway
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Coronoid Notch
Definition: Greatest antero-postero indentation depth on the anterior border of the ramus
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Bevel Orientation – faces mid-sagittal plane… this way …but deflects this way
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Long Buccal Nerve:
Infiltration or “Block”
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QUESTIONS?
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WHAT CAN GO WRONG AND WHAT TO DO ABOUT IT?
PART
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Infiltration of Mandibular
Molars Buccal and lingual
approach 1
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Advantages: • Thin cortical plate • Lingual foramina • Patient acceptance • Lingual nerve blocked already
Lingual Infiltration
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Disadvantages: • Ballooning of tissue • Avoiding submandibular salivary
gland • Vision
Lingual Infiltration
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Patient selection criteria enhancement: • Missing adjacent teeth • Thinner alveolar anatomy • Younger/older patients • Root anatomy visible • Vertical buccal shelf form
Lingual Infiltration
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Technique: • Apical to mucogingval junction • Tissue expands • Avoid submandibular gland • Vision enhanced by position and
tongue retraction
Lingual Infiltration
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Technique: • Where? Just apical to mucogingival
junction • Bevel – facing bone • Depth: 2-3 mm • Volume: 0.5 - 0.7 cc • Onset time: ~ 5 minutes
Lingual Infiltration - Summary
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CONVENTIONAL MANDIBULAR ANESTHESIA
5 TIPS & TRICKS
to think about?
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1 Chin up to the ceiling Head position consistent every time!
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1
• Consistency • Roll of gravity?
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Scissors Mouth
“Rester”
2
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Prop or “rester” Right side goes with right side technique
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3 Volume Considerations • Amount given, then available
time for diffusion • Neuroanatomy (penetrable
diameter)
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How many “carps”
are enough… 2 ? are too much… 4 ?
for a block
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Leonard M, Local Anesthesia Volume and Success Rates, JADA Vol. 126(833)
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Onset
Time
4
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Lip v. Pulpal Anesthesia
Leonard M, Local Anesthesia Volume and Success Rates, JADA Vol. 126(833)
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The Influence of SOLUTION pH
Primarily due to concentration of HCl the LA molecules are dissolved in.
Also proportional to vasoconstrictor concentration and it’s antioxidant, NaHSO3
= H2SO4
5
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The Influence of SOLUTION pH
Cook-Waite / Sterling Research Laboratories
generic name epinephrine pH 3% mepivacaine ~5.4 4% prilocaine ~5.4 4% articaine 1:200,000 ~4.9 4% prilocaine 1:200,000 ~4.9 2% lidocaine 1:100,000 ~4.3 4% articaine 1:100,000 ~4.3 2% lidocaine 1: 50,000 ~3.9
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pH of ~ 5.4 favorable “plain” local anesthetic
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ARTICAINE STATUS, REVERSING, BUFFERING, INHALING LOCAL ANESTHESIA AND TOPICALS
PART
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LOCAL ANESTHESIA SOLUTIONS
EFFICACY
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Articaine
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Articaine Brands: “100” / “200” epinephrine
Septocaine® Orabloc®
Articadent® Zorcaine®
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Articaine
A statistically significant scientific study demonstrated that 4% articaine 1:100K performed more efficaciously than 2% lidocaine 1:100K in controlled clinical administrations.
Kanaa, MD et al, J.Endod 32:296-298,2006
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Articaine
Articaine solutions had a probability of achieving anesthetic success superior to lidocaine when analyzing infiltration.
Brandt RC et al JADA 142(5):493-504 2011
The pulpal anesthetic efficacy of articaine versus lidocaine in
dentistry:
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The pulpal anesthetic efficacy of articaine versus lidocaine in dentistry:
• Weaker, but still significant evidence of articaine’s superiority for mandibular block anesthesia.
• No difference for symptomatic teeth (e.g. irreversible pulpitis)
Brandt RC et al JADA 142(5):493-504 2011
Articaine
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Chemistry: Sulfur atom
The sulfur atom forming the highly lipid soluble thiophene ring is non-reactive.
There is NO cross allergenicity (Ag-Ab) interaction for a patient allergic to “sulfas” or “sodium or potassium metabisulfites”
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H3C NH-CO-CH-NH-CH2-CH2-CH3
CH3
COOCH3 HCI
Structural formula and
physical - chemical data for articaine
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Metabolism – ester component
Although classified as an amide local anesthetic, the articaine molecule is 90% inactivated by plasma cholinesterases and only 10% by hepatic enzymes.
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Metabolism
The good news is: 1. The metabolite from the ester linkage
inactivation is NOT para-amino benzoic acid (PABA), a known allergen.
2. The FAST action results in a short ½ life (27 minutes). This represents a systemic safety phenomenon.
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Search: Safety
These authors could not find a single mortality linked to articaine, in any age group, in it’s years of dental administration in Europe, Canada and currently the U.S.A. Hawkins JM, Moore PA, Local Anesthesia: Advances in Agents and Techniques, Dent Clin N Am 46 2002 719-73
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Search: Adverse Drug Reactions
The product has been available in Germany and France since 1976 and has ~90% of the market, in Canada since 1983 with ~35%, in the United States since 2000, also with ~35%, The authors expected to find ADR reports of post-op sequellae such as lingual nerve and/or inferior alveolar nerve paresthesia.
Hawkins JM, Moore PA, Local Anesthesia: Advances in Agents and Techniques, Dent Clin N Am 46 2002 719-732
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Search Results: ADR’s
This was NOT the case, implying that: Not being reported Not occurring Accepted as an occasional event in
dentistry Aren’t any lawyers in Europe!
Hawkins JM, Moore PA
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Is a 4% solution neurotoxic?
Paresthesia Research is Unavailable
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There is no scientific or research based data to conclude that 4% prilocaine or 4% articaine is directly causitive of dental paresthesia and/or hypesthesia.
…HOWEVER…
Hawkins JM, Articaine: Truths, Myths and Potentials, Academy of Dental Therapeutics and Stomatology 9 2003
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1. Don’t use it for IAN blocks. Do higher blocks?
2. Use selectively – desperation?
3. Mix, match, dilute(?) with 3% mepivacaine plain (Scandanest®, Carbocaine®)
4. Articaine for IAN/Lingual - with consent? 5. Patient selection?
What are YOUR choices?
NOTE: Speaker suggests: Do NOT use on lawyers, news anchor women, any media, family, alleged friends or at 4:00 PM Thursday or Friday afternoons
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Dr. George Gow-Gates, Dr. J. Watson, University of Sydney, Australia
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QUESTIONS?
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OraVerse™ Phentolamine Mesylate
Injection
“Reversing” Local Anesthesia
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reverses SOFT TISSUE ANESTHESIA ONLY
Phentolamine Mesylate is NOT a LOCAL ANESTHETIC
reversal agent
Phentolamine Mesylate
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13% of pediatric patients receiving IANB suffer post-treatment
traumatic injury to soft tissues.
College C, Feigal R, Wandera A, Strange M. Bilateral versus unilateral mandibular block anesthesia in a pediatric population. Pediatr Dent. 22(6):453-457, 2000.
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Adults and Adolescents: 60 Minute Efficacy Data
Time to Recovery of Normal Lip Sensation
0171, Rev. 10/2008
Mandible • 54.8%; p<0.000
Phentolamine mesylate accelerates the return to normal sensation by 85 minutes
• 41% phentolamine mesylate patients fully recovered in 60 minutes
• 7% for control patients
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Pediatric patients also recover sensation in half the time
0360, Rev. 11/2010
Source: Tavares M, Goodson JM, Studen-Pavlovich D, and colleagues. Reversal of soft-tissue local anesthesia with phentolamine mesylate in pediatric patients. JADA 2008;139(8):1095-1104. Copyright ©2008 American Dental Association. All rights reserved. Excerpted by permission.
• Median time to recovery of normal lip sensation compared to control was reduced by: – 120 minutes
(67%) in the mandible
– 53 minutes (47%) in the maxilla
Patients 6-11 years old
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• Easy to Dose − 1:1 cartridge ratio to local anesthetic
with a vasoconstrictor using identical injection site
• Maximum recommended dose − 2 cartridges for adults & adolescents
12 years of age and older − 1 cartridge for patients 6-11 years of
age and over 66 lbs. − ½ cartridge for children 6 years of age
or older weighing 33-66 lbs.
Dosing
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Potential complications
Needle-related:
• Trismus
• Paresthesia
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OraVerse TM
Now sold in sleeves of ten (10)
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OraVerse™ Phentolamine Mesylate
Cost? $8/cartridge
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Onset®
Buffering Local Anesthetic
Orapharma Anutra
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Performance Limitations of Current Anesthetics
•Onset Time Time for body to buffer anesthetic
•Analgesia Is No pain attainable? Always?
• Injection Pain Stinging is a concern for patients
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Control
12%
71%
0%
10%
20%
30%
40%
50%
60%
70%
80%
12% of the control participants achieved pulpal anesthesia in under two minutes
71% of the participants receiving buffered anesthetic achieved pulpal anesthesia in under two minutes
Percentage of Participants Profoundly Numb at 2 Minutes
Onset
Clinical Study Data Pulpal - IANB
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Clinical Data – Pain Free Injections
6%
44%
0%
5%
10%
15%
20%
25%
30%
35%
40%
45%
50%
Zero Injection Pain
Control Onset®
6% of traditional anesthetic patients experienced zero injection pain
44% of buffered anesthetic patients experienced zero injection pain
From: Malamed S, Falkel M, Decreasing anesthetic injection pain using an automated dental anesthetic buffering system: A prospective, randomized, double-blind, crossover study, Draft for Publication, 2011
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Clinical Data – Patient Preference
17% 11%
72%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Which was the most comfortable injection?
No Difference Control Onset®
From: Malamed S, Falkel M, Decreasing anesthetic injection pain using an automated dental anesthetic buffering system: A prospective, randomized, double-blind, crossover study, Draft for Publication, 2011
72 % of patients rated Onset as the most comfortable injection
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30-Minute Time Course, Pulpal Analgesia, IANB
67%
Onset + Lidocaine
Lidocaine
Articaine
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Onset® by Onpharma® The exchange volume is only 0.18 ml.
The first and only chair side approach for precision buffering
of local anesthetic
Cartridge Connector Mixing Pen Bicarbonate Solution
$299.00 Not autoclavable $55.00 / day based on X9 use
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Topical Anesthetics
Product Analysis
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1 2 3 4 5 6
Isolate
Apply and Reapply
Be patient = 90 sec.
Saliva ejector
Dry Don’t talk!
Topical Anesthetic: Compromises
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Topical Anesthetics
• What do you do if you KNOW that the area can’t be isolated (saliva, tongue), or
• The topical won’t penetrate into tissue far enough to cover a deeper block?
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Topical Anesthetics
Patients expect the use of a topical anesthetic!
Dr. Kit Weathers Endo Magic® Founder’s Technique!
Griffin, GA.
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FDA announces
Box Warning Required
Lidocaine Viscous
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Product Analysis: Lidocaine HCl
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“Should not be used for teething
pain”
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Product Analysis: E.M.L.A.
Eutectic Mixture of Local Anesthetic: 2.5% lidocaine + 2.5% prilocaine
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Product Analysis: Oraqix
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Pregnancy
Local Anesthetic News:
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Dental Treatment Safety with Local Anesthetics during Pregnancy 572
5
Cover Story:
Hagai, A, Diav-Citrin, O, Shechtman, S, Ornoy, A, JADA 146(8) Aug 2015
JADA ® AUGUST 2015 JADA 146(8) THE JOURNAL of the AMERICAN DENTAL ASSOCIATION
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Pregnancy: Safety- Local Anesthetics
A prospective, comparative observational study by the Israeli Teratology Information Services (TIS) – 1999 – 2005 n = 210 pregnancies exposed to dental local anesthetics (112 [53%] in 1st trimester) vs. control group = 794 pregnancies not exposed to teratogens
Hagai, A, Diav-Citrin, O, Shechtman, S, Ornoy, A,
JADA 146(8) Aug 2015
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Pregnancy: Safety- Local Anesthetics
The rate of major anomalies was not significant between the groups. There was no difference in the rate of miscarriages, gestational age at delivery or birth weight.
Hagai, A, Diav-Citrin, O, Shechtman, S, Ornoy, A, JADA 146(8) Aug 2015
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Pregnancy: Safety- Local Anesthetics
The most common type of dental treatment was endodontic therapy initiation (43%) and exodontia (31%). Most women were not exposed to additional medications. ~ one-half (51%) were not exposed to dental radiography. 44% were exposed to radiation, mostly bite wings.
Hagai, A, Diav-Citrin, O, Shechtman, S, Ornoy, A,
JADA 146(8) Aug 2015
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Pregnancy: Safety- Local Anesthetics
Lidocaine (1947),prilocaine (1955) and etidocaine are assigned to US Food and Drug Administration pregnancy Category B Mepivicaine (1955), bupivacaine and articaine (2000) are assigned to Category C
Hagai, A, Diav-Citrin, O, Shechtman, S, Ornoy, A, JADA 146(8) Aug 2015
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Pregnancy: Safety- Local Anesthetics
Epinephrine is a catecholamine, which normally is present in the body, with no clear evidence of increased risk of malformation when used during pregnancy with local anesthetics
Hagai, A, Diav-Citrin, O, Shechtman, S, Ornoy, A, JADA 146(8) Aug 2015
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Pregnancy: Safety- Local Anesthetics
Local anesthetics readily cross human placenta Minutes after administration they reach the fetus, which has the ability to metabolize them.
Hagai, A, Diav-Citrin, O, Shechtman, S, Ornoy, A, JADA 146(8) Aug 2015
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Pregnancy: Safety- Local Anesthetics
Practical Implications: There seems to be no reason to prevent pregnant women from receiving dental treatment and local anesthetics during pregnancy.
Hagai, A, Diav-Citrin, O, Shechtman, S, Ornoy, A,
JADA 146(8) Aug 2015
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Pregnancy: Safety- Local Anesthetics
Conclusions: The use of dental local anesthetics, as well as dental treatment during pregnancy, does not represent a major teratogenic risk.
Hagai, A, Diav-Citrin, O, Shechtman, S, Ornoy, A, JADA 146(8) Aug 2015
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Pregnancy: Safety- Local Anesthetics
Despite the reassuring considerations… Dentists are still reluctant to perform dental treatment in pregnant patients AND Women are still reluctant to receive dental treatment during pregnancy.
Hagai, A, Diav-Citrin, O, Shechtman, S, Ornoy, A,
JADA 146(8) Aug 2015
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QUESTIONS?
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“30+ Years of Hits, Misses and Near MiSs-
es”
THE NATIONAL NETWORK for ORAL HEALTH ACCESS
THE 2015 ANNUAL CONFERENCE Indianapolis, Indiana November 16th , 2015
Mel Hawkins, DDS, BScD AN Dentist / Dentist Anesthesiologist
Toronto, ON Canada
Sedation & Anesthesia in Dental Practice
LOCAL ANESTHESIA:
www.sedationdentistry.us [email protected]