living well in today's toxic world

Living Well in Today’s Toxic World

Bonnie Nedrow ND 2014

Your Choice:

To know and act……

Your Choice:

To know and act……

To be uninformed and ignore……

Your Choice:

Avoidance

Daily Detox Habits

Rest

Seasonal Cleanse

Clean Your Fat

Balance Intestinal Flora

Remove Heavy Metals

Why Detox? 80,000 Chemicals Currently in Use

Air Pollution

Water Pollution

Toxic Food

Why Detox? 80,000 Chemicals Currently in Use 3,000 High Volume Chemicals Commonly Encountered in Everyday Life

Chemicals in Foods

Toxic Body Products

Toxins in Your Home

Why Detox? 80,000 Chemicals Currently in Use 3,000 High Volume Chemicals Commonly Encountered in Everyday Life Average of Seven New Chemicals Patented Daily

No Place to Hide

Toxic Lives

Global Issue

100 out of 212 were found

CDC NHANES 4th Report

212 environmental chemicals were tested"

"47%, or almost half, of these 212 chemicals "

were found in "everyone "

ABSTRACT SUNRISE Static Title Slide

What does the EPA say can happen when people are exposed to chemicals?

n  Fatigue"n  Memory loss"n  Headache"n  Nasal congestion"n  Cough"n  Wheezing"n  Respiratory tract

infection "n  Muscle pain"

n  Hearing loss"n  Heart disease "n  Asthma"n  Chronic bronchitis"n  Permanent decrements in lung capacity"n  Permanent decrements in IQ"n  Declines in other measures of brain function"n  Premature birth"n  Cancer "n  Premature death"

"

Why Detoxify?

Endocrine System

§  The endocrine system is made up of glands which produce hormones

§  Hormones bind to cell

receptors to trigger a cellular response

§  Hormones are

messengers which act at very low doses

Endocrine Disruptors

§  Are chemicals which mimic hormones

§  They signal the cell

in the same way hormones do

§  They act at very

low doses

Effects of Endocrine Disruptors

§  Harm developing babies §  Infertility §  Endometriosis/PCOS §  Feminization of males §  Hypothyroid §  Diabetes §  Obesity §  Precocious puberty §  Delayed puberty §  Menopause symptoms

Metals Industrial Chemicals

Pharmaceuticals

Herbicides, pesticides

Sources of Endocrine Disruptors

Herbs and Supplements

Personal Care Products Endocrine

Disruptors Herbicides and Pesticides

Obesogens

§  Obesity is an increasing health problem

§  More than half of the European population is

overweight and up to 30% is obese

§  The prevalence of obesity worldwide has

doubled since 1980

§  Increased body weights have also been

reported in pets and laboratory animals

over the past decades Oxidative Medicine and Cellular Longevity Obesity and Metabolic Comorbidities:

Environmental Diseases? Lubrano etal, March 2013, PMID 235772225

Obesogens

§  Excess caloric consumption and a sedentary

lifestyle are the only recognized risk factors for obesity and

DM but alone do not account for the current worldwide

obesity epidemic.

§  New hypotheses are emerging to explain the

etiopathogenesis of these conditions, including

environmental chemicals, stress, immunological alterations,

micronutrient deficits, and gut microbiota

Oxidative Medicine and Cellular Longevity Lubrano etal, March 2013, PMID 235772225

Obesogens

§  In 2006, Bruce Blumberg developed the “obesogen

hypothesis”, to explain the weight gain effects of certain

chemicals.

§  This hypothesis is supported by laboratory and animal

research as well as epidemiological studies that show

that a variety of EDCs can influence adipogenesis

and obesity.


Obesogens

§  An increase in oxidative stress-associated inflammation has

been hypothesized to be a major mechanism in the

pathogenesis of obesity-related diseases.

§  When perturbed, the mitochondrial system alters the output of

matter and energy and this may result in a pathological

phenotype, such as that of obesity, dyslipidemia, metabolic

syndrome, hypertension, and cancers.


Increase in Diabetes and Chemicals

PMC3121438

What Happens?

PMC2790509

BPA an Obesogen

§  BPA promotes differentiation and lipid accumulation

in primary subcutaneous human pre-adipocytes.

§  BPA induces adipocyte differentiation through a non-classical

estrogen receptor mediated mechanism (rather than through

glucocorticoid receptor activation).

§  These results indicate that BPA can contribute to the final

maturation of cells committed to the adipocyte lineage and

add to the growing body of evidence that BPA acts as an

obesogen.

Bisphenol A induces differentiation of human preadipocytes…

JG Boucher etal Nutrition & Diabetes Jan 2014 PMID: 24418828

Avoidance

§  Drink charcoal filtered water

§  Transport drinking water in glass or a stainless steel clean canteen

Drink Clean Water

§  Whole house charcoal filter

§  Charcoal shower filter §  Crystal-ball bath filter

for chlorine

Wash With Clean Water

§  Shop at your farmer’s market when available

§  Eat whole foods with minimal packaging

Eat Organic Local Foods

§  Exercise away from polluted air

Exercise in Clean Air

§  Check out SkinDeep.com to see if what you currently use is clean

§  Use food grade body products, if you wouldn’t eat it, don’t put it on your skin

Choose Clean Body Products

§  Choose wood over plastic

§  Avoid plastics containing phthalates and BPA (biphenyl-A)

Choose Clean Toys

§  Where do your vitamins and herbs come from?

§  33% of raw materials for vitamins are produced in China

§  Herbs have the highest risk of lead and mercury contamination

Choose Clean Supplements

§  Buy non-toxic cleaning supplies

§  Baking soda §  Vinegar §  Lemon §  Salt

Non-toxic Household Products

§  Remove your shoes when you come in the house

Leave Your Shoes at the Door

§  Use your speaker on your cell phone

Avoid EMF

§  Turn off your wireless router at night

Avoid EMF

§  Create a sleep sanctuary free of EMF, artificial light, disruptive noise, and off-gassing furniture

Your Cleanest Room

Avoidance

Daily Detox Habits

Daily Detox Habit #1

Drink Plenty of Water!

How Munch Water?

1/3 your body weight in ounces

EG: 150# person should drink 50 ounces of water every day


Exercise §  Consistency §  Fun §  Variety

Be Consistent with Exercise

§  Move every day §  Make a plan for all seasons §  Make a plan for travel §  Put it on your schedule

Have Fun with Exercise

§  Take a class §  Join a sport §  Find a gym buddy §  Explore

Exercise Variety

Cardio Strength

Stretch


Phytonutrient Rich Diet

Phytonutrients

Eat a rainbow of produce

Diet High in Produce

Eat 5-7 servings of produce a day


Buy organic when able

Or, buy from the “Clean 15” EnvironmentalWorkingGroup.com


Mind-Body Healing

Mental Imagery

Social Support

Emotional Healing Technique


Deep Breathing

§  Five minutes every day AND §  Three deep breaths when feeling stressed


§  Loofa or exfoliate mitts §  Before your shower or before exercise

Dry Brushing


Oil Rub

§  Before shower §  1-2 Tbsp. oil §  Sesame,

Coconut, or Almond


Contrast Shower

Alternate 30 seconds cool water with 30 seconds of hot water three times


Two to Three Bowel Movements Per Day


§  Probiotics §  Antioxidants §  Fiber §  Multi-vitamin-mineral

Daily Detox Supplements

Avoidance

Daily Detox Habits

Rest

Rest

Several Days a Week Eat Light And Clean

Weekly Rest

§  Slow Down §  Rest §  Relax §  Meditate

Avoidance

Daily Detox Habits

Rest

Seasonal Cleanse

Nutrition

Supplements

Physical Medicine

Mind-Body Healing

Seasonal Cleanse

Seasonal Cleanse Workbook

Nutrition

Seasonal Cleanse

§  Whole food §  Organic §  Hypoallergenic §  Anti-inflammatory

Nutrition

Seasonal Cleanse

Nutrition

Seasonal Cleanse

Elimination of: q Sugar and refined

foods q Coffee and alcohol q Animal products, esp.

eggs and dairy q Soy, corn, gluten q Citrus q Nuts q Tropical fruit

Supplements

Seasonal Cleanse

Mobilize and Eliminate Toxins §  Liver support §  Kidney support §  Bowel scrubbers §  Probiotics §  Antioxidants

Supplements

Seasonal Cleanse

Physical Medicine

Seasonal Cleanse

Open the Emunctories §  Skin §  Kidneys §  Lungs §  Colon

Physical Medicine

Seasonal Cleanse

Colon Hydrotherapy

Physical Medicine

Seasonal Cleanse

Sauna

Sauna

Sauna as a Valuable Clinical Tool for Cardiovascular, Autoimmune, Toxicant-

induced and other Chronic Health Problems Alt Med Review, 2011 Walter J. Crinnion, ND

§  Sauna therapy has been used as a component of

several multi-component depuration protocols.

§  Depuration is a term used to describe the

removal of impurities from the body, especially

from bodily fluids like sweat and urine.

§  Synonyms for depuration include purification and

cleansing.

Sauna Hubbard Method:

The components of the 3-6 week Hubbard protocol are as

follows:

§  Physical exercise for 20-30 minutes daily

§  Radiant heat saunas, 140-180°F, 2.5-5 hours daily

§  A multiple vitamin/mineral with high niacin

§  Water, sodium, and potassium

§  1-8 tablespoons of vegetable oil daily

§  Balanced meals and adequate sleep Alt Med Review, 2011Walter J. Crinnion, ND

Sauna

§  A group of 10 electrical workers with polychlorinated biphenyl (PCB) exposure completed three weeks of the Hubbard Purification Rundown.

§  PCB adipose levels were measured in blood and with needle biopsies.

§  Two groups of patients (A and B) underwent the Hubbard Purification Rundown and another 10 workers served as controls.

§  The six persons in group A appeared to have a reduction in both adipose and serum levels of PCBs, while the four persons in group B had no appreciable changes.

Alt Med Review, 2011Walter J. Crinnion, ND

Sauna

§  Living in chemically-free facilities

§  Two hours daily of radiant-heat sauna therapy (140-160°F)

§  15-30 minutes of exercise daily

§  20-30 minutes of massage daily

§  Niacin – up to 3 g daily

§  Vitamins, minerals, amino acids given orally and IV

William Rea, MD, Director of Environmental Health Center, Dallas


Niacin

§  Niacin can shift the adipose-blood equilibrium of toxin

concentrations by stimulating release of fatty acids from

tissues into the blood

§  Mobilizing free fatty acids has been shown to mobilize fat

stored pesticides and PCBs.

Townsend Letter April 2006 Chemical Exposures at the World Trade Center: Use of the Hubbard Sauna Detoxification Regimen to Improve the Health Status of New

York City Rescue Workers Exposed to Toxicants by Marie A. Cecchini, Ms et al

Sauna At Dr. Rea’s clinic:

§  156 females and 54 males chemically sensitive individuals

§  Dr. Rea reported that 86 percent of the participants noted a

reduction in chemical reactivity.

§  In addition, 57 percent of subjects with abnormal balance and

31 percent of subjects with autonomic nervous system

functional disorders improved.

§  Serum levels of aromatic and aliphatic solvents were reduced

in 63 percent of individuals. Alt Med Review, 2011Walter J. Crinnion, ND

Sauna

§  As of 2006, more than 500 people have completed the program

§  The primary goal of this project is to restore quality of life and

job fitness to those exposed to toxic materials at the WTC site.

§  The focus has been to identify individuals who are not

responding, or not recovering fully, after receiving medical

treatments being offered to WTC exposure victims.

World Trade Center Detoxification Program

Townsend Letter April 2006 by Marie A. Cecchini, Mset al

Sauna


- 3

who are not responding, or not recovering fully, after receiving medical treatments being offered to WTC exposure victims. OUTCOME MEASURES

Individuals are referred to the project because of persistent symptoms following exposure to WTC toxins. The project’s rehabilitative goal emphasizes restored quality of life (“wellness”). Additionally, the project includes ongoing tests to identify the full range of health effects associated with the WTC exposures and evaluating the efficacy of detoxification in resolving specific effects. A complete set of tests are given before and after detoxification.

To evaluate the effectiveness of this rehabilitative therapy, participants are given a structured medical examination. Participants also complete a comprehensive Health History and Symptom Survey developed specifically for this project. This survey gathers basic demographic information; employment history and relevant work exposure questions; recent symptomatology focusing on the cluster of symptoms common to environmental exposures; and the number of lost workdays. Clients also undergo intelligence quotient (IQ) testing, as well as a panel of standard laboratory tests including CBC, comprehensive metabolic panel, thyroid panel, lipid panel, ECG, and urinalysis. THE FIRST THREE YEARS: REVIEW OF 484 CASES

As previously noted, more than 500 men and women who were exposed to World Trade Center contaminants have completed the detoxification program. This report summarizes a recent review of medical folders from the 484 men and women who enrolled in the program between September 2002 and September 2005: 273 firefighters, 52 sanitation workers, 19 paramedics, 23 police officers, and 117 others. Of these, 63 individuals left the program prior to completion. These results indicate a range of benefits that sum up to improved quality of life and job fitness.

The number in each test sample varies to some extent. Certain tests were added or changed as the project evolved, and therefore not all tests were performed on all clients. Results are described only for those individuals who had multiple data points on that test. Emphasis has been placed on the findings of greatest interest. A. Healthy Days and Job Fitness Three core questions from the CDC Health-Related Quality of Life instrument are included in the structured health history and symptom survey. These quantify the number of days physical and mental health was not good, as well as how many days poor physical or mental

Improvement in Health-Related Quality of Life

0

1

2

3

4

5

6

7

8

Poor Health Poor Mental Limited Activity Missed Work

Aver

age

Num

ber o

f Day

s - P

ast M

onth

BeforeAfter

Sauna

Townsend Letter April 2006 Marie A. Cecchini, Mset al

- 4

health kept each individual from doing their usual activities, such as self-care, work, or recreation. These were completed by all clients who underwent detoxification after June 2005.

• Prior to enrollment individuals averaged 4.4 days of limited activity and 2.1 days missed work per month.

• After detoxification, these individuals reported 0.2 days of missed work or limited activities – this includes the month they underwent therapy. (See Figure 1.)

A majority of rescue workers seeking detoxification treatment are concerned that their health problems might force them to leave their jobs. The majority of these individuals are between 35 and 45 years of age (ranging from 20 to 77 years); many have young children. While forced retirement of these men would be costly to the city, the disability benefits that each individual man might expect are not sufficient to support a family. Thus, anxieties about health are compounded by financial concerns and further complicated by a determination to continue on the job without mentioning symptoms. B. Symptom Severity

The Health History and Symptom Survey consists of 50 items on ten scales for systems commonly impacted by chemical exposure and is used to assess changes in symptoms over the course of sauna detoxification. Responses are normalized to take into account the fact that there are different numbers of questions per category of symptoms. Improvements on all symptom scales—manifestations consistent with exposures to the range of toxicants known to be released at the WTC site—were especially strong. (See Figure 2.) C. Need for Medication The case review revealed that almost half the individuals were taking as many as 16 medications to relieve their exposure symptoms. At program completion, 84% of those clients no longer required medication because their exposure symptoms abated. Of the seven percent still taking medicine, use was reduced to only a single medication in most cases. As these symptoms abate, clients are able to reduce and ultimately eliminate the medications they are taking. (See Figure 3.) These clients work in professions that require a high level of fitness. Those who had been on medications for an extended period experienced the side effects as unwelcome (if not dangerous) impediments to both their accustomed state of well-being and their job fitness.

Change in Use of Medications with Detoxification: N = 324

Change in Symptom Severity with Detoxification

0 5 10 15 20 25 30 35 40 45 50

Immunological

Musculoskeletal

Gastrointestinal

Cognitive

Emotional

Neurologic

EENT

Respiratory

Cardiac

Skin

Cumulative Symptom Severity Score

BeforeAfter

Sauna


- 5

012345+

Number of Medications Before Number of Medications After

D. Vestibular Function Impairment of vestibular function is associated in the literature with toxic exposures.34,35 The postural sway test is a sensitive and reliable method of measuring balance developed for field use measuring the mean speed along the path moved with eyes open and when eyes are closed.23 Pre/post detoxification balance testing was completed on a random cohort of firefighters exposed to WTC toxins. There is a statistically significant difference (p = 0.12) between sway test results before and after detoxification, with the pre-detoxification measurements significantly impaired, as demonstrated by increased sway speed, compared with predicted results of reference populations (see the “zero” line in Figure 3). Balance is crucial to firefighters. If balance is impaired, a firefighter may not be able to remain upright in a dark area. Following detoxification, the exposed firefighters have sway test values that approach those of an unexposed reference population. (See Figure 4.) E. Reaction Time Impairment of Choice Reaction Time (CRT) has been previously shown in firefighters exposed to PCBs.21,32 CRT testing measures cognitive function: vigilance, discrimination, and speed of reaction (abilities that are obviously crucial to firefighters, police, or paramedics). Pre/post detoxification CRT testing was completed on a random cohort of firefighters exposed to WTC toxins. Firefighters have faster than predicted measures of both Single Reaction Time (SRT) and CRT, as seen in the negative variance from predicted results. The improvement in CRT following detoxification is statistically significant (p < 0.1) and suggests improvement in cognitive function. (See Figure 5.)

Change in Balance TestN=53

1.211.20

1.13

1.07

1

1.05

1.1

1.15

1.2

1.25

1.3

Eyes Open Eyes Closed

Per

cen

t of

Pre

dic

ted

Val

ues

BeforeAfter

Change in Reaction Time With DetoxificationN=58

471.93

249.07

447.19

242.36

200

250

300

350

400

450

500

Mean Simple Reaction Time (SRT) Mean Choice Reaction Time (CRT)m

illis

econ

ds

BeforeAfter

Change in Reaction Time With DetoxificationN=58

471.93

249.07

447.19

242.36

200

250

300

350

400

450

500

Mean Simple Reaction Time (SRT) Mean Choice Reaction Time (CRT)

milliseconds

BeforeAfter

Sauna

Townsend Letter April 2006 Marie A. Cecchini, Mset al

- 5

012345+

Change in Use of Medications with Detoxification: N = 324

Number of Medications Before Therapy Number of Medications After Therapy

Sauna

Participants at Dr. Cinnion’s clinic in Seattle underwent depuration five days weekly for a minimum of three weeks. The protocol used was as follows:

§  Physical exercise15-20 minutes daily

§  Sauna 3 60-minute sessions daily

§  Glass-bottled spring water and electrolyte replacement

§  Ginger/yarrow tea

§  Constitutional hydrotherapy


Sauna

§  Colonic irrigations daily for 50 minutes

§  Herbal supplement for liver(Chelidonium majus, Chionanthus

virginicus, Arctium lappa, Taraxacum, Urtica dioica,

Arctostaphylos uva-ursi, Silybum marianum)

§  Dietary avoidance of adverse food reactors

§  Dietary avoidance of fruits and vegetables with high amounts

of pesticide residues

§  Dietary avoidance of sugar

Sauna as a Valuable Clinical Tool for Cardiovascular, Autoimmune, Toxicant-

induced and other Chronic Health Problems Alt Med Review, 2011 Walter J. Crinnion, ND

Sauna

Self-reported results for Dr. Crinnion’s clients undergoing the three week program.

Alt Med Review, 2011 Walter J. Crinnion, ND

Sauna

§  Induced sweating appears to be a potential method for

elimination of many toxic elements from the human body

§  Concomitant loss of trace minerals into sweat, which is also

evident from the data, serves to remind that sauna users

should secure adequate intake of required minerals to

compensate for losses.

Arch Environ Contam Toxicol July 2010 Blood, Urine, and Sweat (BUS) Study:

Monitoring and Elimination of Bioaccumulated Toxic Elements

Stephen J. Genuis et al

Sauna

§  Serum levels of various xenobiotics do not necessarily reflect

the total body burden of such compounds because accrued

toxicants may store in tissues, and serum levels may belie

actual toxicant status.

§  Biomonitoring for toxic elements through blood and/ or urine

may underestimate the total body burden of such toxicants.

§  Sweat analysis should be considered as an additional method

for monitoring bioaccumulation of toxic elements in humans.

Arch Environ Contam Toxicol July 2010 Stephen J. Genuis et al

Sauna

Toxicol Ind Health. Sep 2012 PMC3573677 Methamphetamine exposure and chronic illness in police officers significant improvement with sauna-based detoxification therapy

Gerald Ross et al

§  Study on treatment of law enforcement personnel with repeat exposure to methamphetamine and related chemical compounds.

§  Most toxic effects from methamphetamine appear transitory, but some of the exposed Utah police officers developed chronic symptoms.

§  This report is of an uncontrolled retrospective medical chart evaluation of symptomatic officers treated with a sauna detoxification protocol designed to reduce the chronic symptoms and improve

the quality of life.

Sauna

Toxicol Ind Health. Sep 2012 Gerald Ross et al

The abnormal findings include

§  elevated blood lipids: 58%

§  elevated liver function tests: 41%

§  positive rombergism (inability to maintain balance in a

‘tandem stance’ without visual input): 35%

§  hypertension: 28%

§  high blood glucose: 19%

§  low blood testosterone: 17%

§  low blood thyroid: 17%.

Sauna


Reported improvement:

§  Participants averaged 5.8 h of sleep per night pre-treatment,

which improved to 7.6 h on completion.

§  The mean pre-treatment neurotoxicity score was 65.5

(SD = 24.8), while the post-treatment mean score was 14.6

(SD = 11.5, p < 0.001).

Sauna


More than 75% of officers reported all the following nine sxs:

§  fatigue

§  insomnia

§  headaches

§  heartburn

§  personality changes

§  numbness in hands and/or feet

§  memory loss

§  a prior history of allergy symptoms and/or

§  poor concentration

Physical Medicine

Seasonal Cleanse

Steam Soak

Physical Medicine

Seasonal Cleanse

Yoga

Seasonal Cleanse

Mental Imagery

Social Support

Emotional Healing Technique

Mind-Body

Healing

Mind-Body

Healing

Seasonal Cleanse

Mental Imagery

Mind-Body

Healing

Seasonal Cleanse

Emotional Healing

Mind-Body

Healing

Seasonal Cleanse

Social Support

Seasonal Cleanse

Case Study:

q 39 year old Caucasian male

q Cc: fatigue, poor exercise tolerance, recurrent bronchitis

several times a winter, over-weight by 50#

q Spring 2012 participated in 4 week Seasonal Cleanse program

q Weight loss of 20 pounds with self-reported increased vitality

q Repeated cleanse twice yearly 2012 and 2013 with slowly

improved energy and less dramatic weight loss

Seasonal Cleanse

Case Study:

q First incidence of pneumonia winter 2013

q Fhx: sister diagnosed with breast cancer age 42 q Concern about own health and vitality

q Started taking rest and early bedtime seriously q Started keto-adaptation program June 2014

q Loss of 20 pounds over 4 months for a total of 50# loss since first cleanse

q Drop of HgA1C from 5.6 to 5.0 from pre-cleanse to end of

phase three keto-adaptation

Seasonal Cleanse

Case Study:

q Began phase four of keto-adaptation September 2014

q Completed 4 week cleanse in September, eating classic cleanse diet and fasting one day a week

q Best cleanse ever, felt fantastic q Rides bike 50 miles on a weekend day while fasting to

maintain ongoing keto-adaptation q Eats a high complex carb diet including roots, fruits, grains

and legumes with moderate fat and less protein than prior diet

Avoidance

Daily Detox Habits

Weekly Rest Seasonal Cleanse

Clean Your Fat

Four Day Fat Flush

1.  Eat healthy fat

2.  Decrease digestion/absorption of the fat

3.  Bind the fat in the intestines with fiber

4.  Purge the fat

A strategy to decrease fat soluble toxins from your fat stores:

Four Day Fat Flush

1. Eat healthy fat §  Eat a diet high in organic produce with adequate protein

§  In the morning, on an empty stomach, eat organic ghee

or olive oil (you can mix olive oil with a lemon, or ghee

with a small amount nut milk and cinnamon)

§  Build up over four days to

3-4 TBSP oil on the last morning

Fat Flush

Journal of Nutritional Biochemistry 18 (2007) 163–167 Enterohepatic circulation of organochlorine compounds: a

site for nutritional intervention. Jandacek etal

§  Non-absorbable dietary lipids reduce the absorption of

dietary organochlorines and also increase the rate of

their fecal excretion.

§  Organochlorine compounds that are stored in the body

enter the intestine both in bile and through a poorly

understood non-biliary mechanism.

Fat Flush

§  In the normal fat absorption process, the presence of

an oil phase in the small intestine is transient, since rapid

hydrolysis and absorption results in disappearance of

essentially all tri-acyl-glycerol before it passes from the

proximal to the distal small intestine.

§  Fats that are not hydrolyzed and absorbed maintain

an oil phase during gastrointestinal transit through

the small and large intestines.

Journal of Nutritional Biochemistry 18 (2007) Jandacek etal

Fat Flush

§  When olestra accounted for 50% of the dietary fat,

cholesterol absorption was approximately one third of

that seen without dietary olestra.

§  In humans, inclusion of 14 g/d of olestra in the diet

decreased cholesterol absorption from 47% to 56% of

that ingested.


Fat Flush

§  Inclusion of olestra in the diet resulted in interruption of

enterohepatic circulation of hexachlorobenzene and

reduction in all tissues even during the periods of caloric

restriction.

§  These observations suggest that an appropriate regimen for

the removal of lipophilic toxins is the combination of caloric

restriction and the interruption of enterohepatic circulation

with a non-absorbable fat. Effects of yo-yo diet, caloric restriction, and olestra on tissue

distribution of hexachlorobenzene American Journal of Physiology - Gastrointestinal and Liver Physiology February 2005 Jandacek etal

Four Day Fat Flush

2. Decrease digestion/absorption of the fat

§  Take lipase inhibiting herbs

prior to eating fat (including meals)

§  Our formula: Aesculus,

Eleuthrococcus, Dioscorea,

Panax Ginseng

Fat Flush

§  Inhibition of pancreatic lipase has the result of

maintaining an oil phase in the intestine consisting of

unhydrolyzed dietary fat.

§  This fat moves from the small intestine to the large

intestine and the feces.


Fat Flush

§  Presumably, the use of a lipase inhibitor, such as orlistat,

will also result in partial blockage of the enterohepatic

circulation of lipophiles by providing an undigested

intestinal triacylglycerol phase that will solubilize these

compounds.

American Journal of Physiology - Gastrointestinal and Liver Physiology February 2005 Jandacek etal

Fat Flush

Br J Nutr. 2010 May; Impact of adopting a vegan diet or an olestrasupplementation on

plasma organochlorine concentrations: results from two pilot studies. PMID 20030906 Arguin etal

§  Olestra had a favorable influence on beta-

hexachlorocyclohexane but did not prevent plasma

hyper-concentration of the other OC (including DDT)

during ongoing weight loss

§  There was a trend toward lesser contamination (of

organochlorines) in vegans than in omnivores

Four Day Fat Flush

3. Bind the fat in the intestines with fiber §  Syllium,

§  Rice-bran fiber

§  Chia seeds

§  Cholestyramine

§  Chitosan

Four Day Fat Flush

Bios. Biotechnol. Biochem 2012 Effect of Chitosan Intake on Fecal Excretion of Dioxins

and Polychlorinated Biphenyls in Healthy Man Kohda etal

§  Study of six healthy men

§  Chitosan promoted the fecal excretions of dioxins and PCBS

§  Chitosan has been reported to inhibit pancreatic lipase

§  Chitosan promoted the excretion of fecal dioxins together

with increased secretion of fecal fat

Four Day Fat Flush

Bios. Biotechnol. Biochem 2012 Effect of Chitosan Intake on Fecal Excretion

of Bisphenol A and DEHP in Rats Kohda etal

§  Similar study using BPA and DEHP

§  Chitosan significantly increased excretion of

both fat soluble chemicals and fat

Four Day Fat Flush

4. Purge the fat

§  Epson salts

§  Laxative

§  Prune juice

§  Castor oil

§  Enema

§  Colonic

Keto-Adaptation

Keto-adaptation is not: q  A diet

q  A life-style q  A belief system

Keto-adaptation is: q  A training program to increase fat burning q  A tool to stabilize blood sugar and lose weight

q  A tool to reduce inflammation

Keto-Adaptation

Keto-adaptation creates the opportunity for: q  Weight loss

q  Fat-soluble toxin mobilization q  Protein sparing metabolism

q  Lowered blood sugar q  Decreased sugar cravings

Weight Loss

PMC3875914

q  Study demonstrated long term weight loss of at least

10% body weight sustained for one year

q  Program consisted of two phases of short term ketogenic

diet alternating with longer periods of Mediterranean diet

Weight Loss

PMC3875914

Fat-Soluble Toxin Mobilization q  Body weight loss increases plasma and subcutaneous

adipose tissue concentrations of organochlorine pesticides

and PCBs in obese subjects.

q  These results raise concerns about an undesired and

potentially harmful side effect of weight loss in some obese

patients who seem to be at greater risk of health problems

than leaner subjects since they show higher organochlorine

body burden.

PMID: 11093288

Fat-Soluble Toxin Mobilization Body weight loss increases plasma and adipose tissue concentrations of potentially toxic pollutants in obese individuals

PMID: 11093288

Protein Metabolism in Citric Acid Cycle

Beta-Oxidation Fats

PMC3875914

Stabilization of Blood Sugar

Decrease Carbohydrate Craving

q Consumption of a high- compared with a low-GI meal increased the activity in brain regions related to food intake, reward, and craving in the late

postprandial period.

q And was coincident with lower blood glucose and

greater hunger.

PMID: 23803881

Keto-Adaptation

Three Month Keto-adaptation Program q  Eat a very low carb diet

q  Monitor ketones with glucometer

q  Adjust the diet to stay “in the zone” of 1.0-3.0mMol

ketones

q  Monitor body composition with BIA

q  Monitor blood work: lipids, HgA1C, uric acid, hs-CRP,

electrolytes, liver enzymes

Keto-Adaptation

Four Phases of Keto-adaptation

q Phase one: liver adaptation

q Phase two: brain and muscle adaptation

q Phase three: kidney adaptation

q Phase four: post-adaptation using the ability

to easily go into ketosis as desired

Ketoadaptation and Detox

q  Fat flush for every one to three pounds lost

q  Supplementation with trace minerals, high dose potassium,

moderate calcium, and magnesium-citrate TBT

q  Daily fiber supplementation

q  Daily probiotics

q  Colon hydrotherapy PRN

q  Sauna as able, or alternative Epson salt bath

q  Castor oil packs as indicated

q  Daily detox habits


q  EFAs and Vitamin E, especially for high animal protein diets

q  Glycoproteins, especially for vegetarian diets

q  Basic detox nutrients 6-12 per day PRN

q  Increased protein supplementation during phase one and

two adaptation, consider hemp, pumpkin, whey

q  When uric acid high before the program, add uric acid

dumping herbal formula and potassium citrate @ 990mg/

day (make sure client is taking cal-mag and trace minerals)


q  Carbohydrates from 7-9 servings of above ground vegetables

per day, organic or clean 15

q  Consume hormone free, grass-fed, organic animal products

when able, rely more on hemp and pumpkin protein powder

when not available

q  Exercise and sleep: two other really important factors…..stay

tuned in future lectures!

Keto-Adaptation

Keto-adaptation allows for: q  Rotation diets between high complex carb diet and

ketogenic diet for optimal long term health goals. q  Ability to choose a low-carb diet, a low-fat

diet, or any other diet ideal for that person at that time in their life.

q Ability to do intermittent, protein sparing fasting for a variety of health benefits

Keto-Adaptation

Case Study: q  52 year old female

q  Cc: weight gain 20# since injury 4 years prior, with continued weight gain of 2-3 pounds per year despite

regular cleansing, healthy diet, and regular exercise q  Cc2: reactive hypoglycemia with irritability and anxiety

almost daily unless diet well controlled with regular meals and snacks

Keto-Adaptation

Case Study: q  Began keto-adaptation Aug 2013

q  Weight loss in first 8 weeks of 10#, half muscle and half fat per BIA

q  Next eight weeks another 5# loss, with 3# muscle gain and 8# fat loss

q  Last 5# was lost one pound a month, IBW @ 11 months into program

q  Muscle mass at end of program 38%, fat mass 20.5%

Keto-Adaptation

Case Study: q  Historic liver enzymes, ALT, AST, and GGT for this client

was in the teens or low twenties since first tested 15 years prior

q  Blood work assessed at the end of four weeks, after 15# weight loss

q  ALT: 48, AST: 32, GGT: 24 q  Completed 3 fat flushes over the next 6 weeks

q  Retest ALT: 22, AST: 19, GGT: 12

Keto-Adaptation

Case Study: q  Current diet 15 months into program: complex carbs

including all vegetables and fruits, minimal grains and legumes, more fat and less protein than prior to adapting

q  Fasts 16 hours 2 days a week (dinner to lunch) and 24 hours one day a week (dinner to dinner) to maintain

keto-adaptation q  IBW maintained, liver enzymes stable

q  No longer has any symptoms of hypoglycemia

Avoidance

Daily Detox Habits

Weekly Rest

Fat Flush

Seasonal Cleanse


Intestinal Flora

Balance Flora: §  Increase prebiotics §  Increase probiotics §  Balance bacterial §  Reduce yeast §  Reduce parasites

Gut Pathog. 2012 Nov 30. Saad R etal

Intestinal Flora

§  Pharmacogenomics is a well-established term that

describes the effect of human genome variations

on drug disposition and action.

§  To specify the impact of the human-associated

microbiome on drugs, we have coined the term

pharmacomicrobiomics

Gut Pathog. 2012 Nov 30. Saad R etal

Intestinal Flora

§  Gut-associated microbes can alter drug metabolism directly by

producing enzymes that degrade or activate the drug

molecules,

§  or by competing with drug molecules over the metabolizing

enzyme.

§  In addition, the gut microbiota may exert its influence by

modulating the activity or altering the levels of the host’s drug-

metabolizing enzymes,

§  or by producing enzyme-inducing metabolites that are

originally derived from diet.

Gut Pathog. 2012 Nov 30 Saad R etal

Intestinal Flora

§  Gut microbes outnumber human cells by a factor of 10, yet

we know surprising little about many of these organisms.

§  The meta-genomic sequencing of the human microbiome

reveals that there are 3.3 million non-redundant genes, with

over 99% of the genes being of bacterial origin.

§  The gene set is 150-times larger than the human genome.

Environ Health Perspect. 2012 Mar; Do interactions between gut ecology and

environmental chemicals contribute to obesity and diabetes? PMC3295356 Snedeker SM etal

Intestinal Flora

Intestinal Flora

Environ Health Perspect. 2012 Mar; Snedeker SM etal

§  Microbial populations and/or metabolic capacities are

known to differ in obese and lean subjects (and in type 2

diabetes), yet we know surprisingly little about the effect of

these differences on the body burden of obesogenic and

diabetogenic chemicals.

Intestinal Flora


Individual variations in gut micro-biota effect the body burden

of environmental chemicals by altering:

a)  these chemicals directly

b)  the level and activity of host phase I and II enzymes,

c)  entero-hepatic circulation of environmental chemicals,

d)  depletion of host detoxification capacity, and/or

e)  alterations of gut barrier function

PLoS One. 2013 Jun 2. Lowbush wild blueberries have the

potential to modify gut microbiota and xenobiotic metabolism in the rat colon.

PMC3696070 Lacombe etal

Intestinal Flora

§  Diet has an influence in shaping the development and

composition of the gut microbiota, which is also defined by

host genetics and the bacteria acquired at birth

§  Recent evidence suggests that gut microbial metabolism

has a strong potential for both the bioactivation of essential

nutrients and detoxification

Intestinal Flora

§  The present study observed a 20% increase in

xenobiotic degradation with a diet high in

blueberries

§  Specifically, a two-fold increase in benzoate

degradation of SD rats fed a Low-bush Wild

Blueberry diet

PLoS One. 2013 Jun 2. Lacombe etal

Avoidance

Daily Detox Habits

Rest

Seasonal Cleanse

Clean Your Fat


Remove Heavy Metals

Heavy Metals

Cadmium: §  Breast cancer §  Prostate cancer §  Kidney failure Mercury: §  Developmental delays §  Infertility Lead: §  Dementia §  Mental retardation

Avoidance

Daily Detox Habits

Rest

Seasonal Cleanse

Clean Your Fat


Remove Heavy Metals

How Detoxification Can Help

December 17th, 2014 "Crucial Issues in the Diagnosis and Treatment of Metal Toxicity" with Lyn Patrick, ND January 27th 2015 "The Beauty Bluff: How Toxins in Personal Care Products Can Cause Harm" with Anne Marie Fine, N.D. March 2015 "Endocrine Disruptors and Thyroid Conditions" with Lyn Patrick, ND May 2015 Subject and Speaker TBA July 2015 "Compartments of Toxicants and Testing Options" with John Hibbs, ND Have ideas for a webinar? Write us at: [email protected]

Upcoming NAEM Webinars

Questions?

Unused Slides for Future Presentations

§  Observations of Calvani et al. (2010), who detected

differences in the levels of microbial metabolites in the urine of

obese compared with lean individuals.

§  Bariatric surgery has been shown to alter gut ecology (Furet et

al. 2010; Zhang et al. 2009) and improve glycemic control in

type 2 diabetics

Intestinal Flora


Anti-inflammatory Effects of Fasting q Fasting attenuated immediate hypersensitivity

symptoms.

q D-BHB generated by fasting plays an important

role for the sedate excess immune response

against immediate hypersensitivity.

q Further investigations of the role of ketone bodies in immunological function needed to understanding the molecular mechanisms for the positive health benefits of fasting. PMID: 25302070

Intestinal Flora

Gut Pathog. 2012 Nov 30. Gut Pharmacomicrobiomics: the tip of an iceberg of complex interactions between

drugs and gut-associated microbes. PMC3529681 Saad R etal

§  The gut microbiota is the most predominant and

most diverse microbial community residing in the

human body

§  It comprises hundreds of microbial species,

together constituting about 10 times the number

of body cells

In addition to their role in energy harvesting in the gut,

microbiota may also affect obesity and diabetes risk via several

other mechanisms including:

§  regulation of fat storage

§  metabolic endotoxemia-induced inflammation

§  levels of satiety factors such as glucagon-like peptides and

leptin

Intestinal Flora


living well in today's toxic world

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