liver transplant pierre png and andrea de cruz liver donated will be regenerated by the body
TRANSCRIPT
Liver Transplant
Pierre Png and Andrea De Cruz
• Liver donated will be regenerated by the body
ASSIMILATIONASSIMILATION
Transport and use of absorbed food by body cells
Food substances are converted to new protoplasm and used to provide energy.3
After a hearty meal….
in pancreas
When you are fasting…
in pancreas
6
Polypeptides
amino acids
protein
weak bonds
Protein formation
Amino acid as the building blocks for
proteins
Deamination of amino acid
What are we going to learn today?
The 6 important functions of the liver!
What are the functions of the Liver?
1. Regulation of blood glucose concentration
2. Protein synthesis3. Metabolism (deamination) of amino
acid4. Iron storage
Iron storage
• Worn-out red blood cells – destroyed in spleen (a gland found near the liver).
• Liver breaks down the hemoglobin and stores the iron.
• Bile pigments are also formed from the breakdown of haemoglobin.
liver
gall bladder
duodenumsmall intestines
kidney
pancreas
spleen
stomach
Locate the spleen ! Locate the spleen !
What are the functions of the Liver?
1. Regulation of blood glucose concentration
2. Protein synthesis3. Metabolism (deamination) of amino
acid4. Iron storage5. Production of bile
How about fatty acids and glycerol??
Liver secretes bile salts.
Fatty acid
It has an acidic group (-COOH) linked to a long hydrocarbon chain denoted by R.
R COOH
How are fatty acids are
transported?
LiverLiver
Lymphatic systemLymphatic system
Circulatory systemCirculatory system
Fatty acids and glycerol recombines and
diffuse into lymph vessels
How are fatty acids (from fats) utilized?
• least to be broken down• converted by the liver, to forms that can
be oxidised and stored
• used to build protoplasm (e.g. in cell membrane)
adipocytes
adipocytes
What are the functions of the Liver?
1. Regulation of blood glucose concentration
2. Protein synthesis3. Metabolism (deamination) of amino
acid4. Iron storage5. Production of bile6. Detoxification (breakdown of alcohol)
Detoxification
• Is the process where harmful substances are converted into harmless ones
• Alcohol is broken down by alcohol dehydrogenase (an enzyme) to give
acetaldehyde (a compound)
• Acetaldehyde can be broken down further during respiration to provide energy for cellular activities
Class Activity
Effects of excessive consumption of Alcohol.Effects of excessive consumption of Alcohol.Nervous system
Addictive ( strong desire to drink alcohol)
Depressant (slow down function of the brain
loss of muscular control, slow down reaction time and poor judgment high accident rates in drunk drivers
reduced self-control
unconsciousness
Effects of excessive consumption of Alcohol.Effects of excessive consumption of Alcohol.
Stomach ulcer
Alcohol stimulates secretion of acid in stomach and causes irritation of its wall
Effects of excessive consumption of Alcohol.Effects of excessive consumption of Alcohol.
Circulatory system
Dilation of blood capillaries under the skin:more blood flows to skin
Causes heart related diseases
Effects of excessive consumption of Alcohol.Effects of excessive consumption of Alcohol.
Social effects
Neglect family and workCreate family and financial problemsIncreases crime rates
Becomes aggressive and violent
Effects of excessive consumption of Alcohol.Effects of excessive consumption of Alcohol.
Liver damage
Liver cirrhosisliver cells destroyed and replaced by fibrous tissue
Not enough healthy liver cells for function.
Hardening of the liver
Leads to death
Normal Liver -----Liver Inflammation-- Liver Cirrhosis--- Alcoholic Fatty Liver
Healthy Liver Unhealthy Liver
Functions of the Liver
1. Regulation of blood glucose concentration
2. Protein synthesis3. Metabolism (deamination) of amino
acid4. Production of bile5. Iron storage6. Detoxification (breakdown of alcohol)
Thus, the Liver remains the…
• Largest and most important metabolic organ in the body!
End.
INGESTION
DIGESTION
ABSORPTION
ASSIMILATION
EGESTION
Taking in food
Breakdown of complex food substances to
soluble food substances
Digested food diffuses into bloodstream
Transport and use of absorbed food by body cells
Removal of undigested food
Have we learnt?Have we learnt?
7-Year-Old Girl Has Six Organs Removed for Tumor
Surgery Doctor (Surgeon)• Dr. Tomoaki Kato • New York-Presbyterian
Morgan Stanley Children's Hospital
Patient:• Heather McNarama
Auto-transplantation is the transplantation of tissue from one part of the body to another in the same individual.
What is your view about legalizing organ
transplant?
Class activity
Main Function of the liver