liver dialysis is set to become a reality

1
A new liver dialysis procedure may help criti- cally ill patients survive long enough to get a liver transplant, according to a report by HealthScout news service. Known as albumin dialysis, researchers in the USA at the University of Michigan say the sys- tem works in a similar manner to kidney dialysis in that blood is removed from the body, toxic substances are filtered out, and healthy blood is returned to the body. Albumin is a substance that grabs toxic sub- stances and transports them through the blood to the liver. In people with diseased or damaged liver, these toxins stay in the blood and cause damage, explains the report. In albumin dialysis, blood is pumped out of the body and filtered through a thin membrane containing albumin. The albumin on the membrane extracts the tox- ins from the blood and removes them. The fil- tered blood is then pumped back into the body. The researchers have already used the device on 20 very ill liver-failure patients in a prelimi- nary clinical trial with promising results, says the report. Two patients recovered complete liver function. Almost all of the remaining patients showed some improvement in liver function tests, and six patients lived long enough to receive a liver transplant. US companies GE Power Systems, a division of General Electric Co, and Osmonics Inc have signed an agreement to merge Osmonics into a wholly-owned subsidiary of GE in a stock and cash transaction. John Rice, president and CEO of GE Power Systems says that the fit between the two compa- nies will allow it to better serve the water needs of its global customers. “By combining Osmonics’ excellent technolo- gy and engineering resources with the comple- mentary capabilities of GE Water, we will create an even broader portfolio of products and ser- vices that we can offer for a wide range of energy and industrial applications worldwide. In addi- tion, we are excited about the commercial syner- gies with GE Betz and GE Consumer Products,” said Rice. In the merger, Osmonics shareholders will receive the equivalent of US$17.00 of GE com- mon stock for each share of Osmonics. Shareholders may elect to receive US$17.00 in cash per share instead of GE shares, subject to proration, so that the total cash paid does not exceed 55% of the total merger consideration. The merger, which is subject to the approval of the holders of a majority of Osmonics’ out- standing common shares, government approvals and other customary conditions, is expected to close in the first quarter of 2003. Following the completion of the acquisition, Osmonics will be integrated with GE Water, a unit of GE Power Systems. “Osmonics has a solid product line with excel- lent opportunities for growth, but we needed the resources of a larger organization to take the company to the next level,” said Dean Spatz, chairman and CEO, Osmonics. GE Water, which is based in Guelph, Ontario, Canada, serves the industrial water services market that includes power, semicon- ductors and electronics, petrochemical, oil and gas, pulp and paper, food and beverage, phar- maceutical and health care. In other, unrelated news, Osmonics Medical Systems has been launched to market water purification systems and related equipment to the medical dialysis market. The new division combines 30 years of the company’s dialysis water treatment expertise with the turnkey capability gained from the acquisition of ZyzaTech during 1999. Osmonics Medical Systems will combine proven water treatment system designs with complete customer care packages in an effort to improve patient safety and comfort, while reducing the overall cost to the clinic of oper- ating the equipment. The company says an increased focus on long-term partnerships with dialysis care providers will be a primary objective. The products are manufactured at Osmonics’ facility in Kent, Washington. John Rickert, the division’s business manager, says that the company also will be expanding its range to include 510(k) compliant disinfection systems, and mixing and delivery products. The division is aiming to offer providers a single source of compliant equipment as well as an ongoing service relationship to ensure that all components are well maintained. For more information, contact: Osmonics Inc, 5951 Clearwater Drive, Minnetonka, MN 55343, USA. Tel: +1 952 933 2277, Fax: +1 952 933 0141. Or contact: GE Power Systems, 4200 Wildwood Parkway, Atlanta, GA 30339, USA. Tel: +1 770 859 6948, Fax: +1 770 859 7513. GE Power Systems to broaden product portfolio with Osmonics acquisition ISSN 0958-2118 /02/$22.00 © 2002 Elsevier Science Ltd. All rights reserved This journal and the individual contributions contained in it are protected under copyright by Elsevier Science Ltd, and the following terms and conditions apply to their use: Photocopying Single photocopies of single articles may be made for personal use as allowed by national copyright laws. Permission of the publisher and payment of a fee is required for all other photocopying, including multiple or systematic copying, copying for advertising or promotional purposes, resale, and all forms of document delivery. Special rates are available for educational institutions that wish to make photocopies for non-profit educational classroom use. Liver dialysis is set to become a reality Contents News 1 Feature: Hydrogen-based membrane-biofilm reactor solves oxidized contaminant problems 6 Patents 10 Research Trends 14 Events Calendar 15 ISSN 0958-2118 November 2002

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Page 1: Liver dialysis is set to become a reality

A new liver dialysis procedure may help criti-cally ill patients survive long enough to get aliver transplant, according to a report byHealthScout news service.

Known as albumin dialysis, researchers in theUSA at the University of Michigan say the sys-tem works in a similar manner to kidney dialysisin that blood is removed from the body, toxicsubstances are filtered out, and healthy blood isreturned to the body.

Albumin is a substance that grabs toxic sub-stances and transports them through the bloodto the liver. In people with diseased or damagedliver, these toxins stay in the blood and cause

damage, explains the report. In albumin dialysis,blood is pumped out of the body and filteredthrough a thin membrane containing albumin.The albumin on the membrane extracts the tox-ins from the blood and removes them. The fil-tered blood is then pumped back into the body.

The researchers have already used the deviceon 20 very ill liver-failure patients in a prelimi-nary clinical trial with promising results, says thereport. Two patients recovered complete liverfunction. Almost all of the remaining patientsshowed some improvement in liver functiontests, and six patients lived long enough toreceive a liver transplant.

US companies GE Power Systems, a divisionof General Electric Co, and Osmonics Inchave signed an agreement to merge Osmonicsinto a wholly-owned subsidiary of GE in astock and cash transaction.

John Rice, president and CEO of GE PowerSystems says that the fit between the two compa-nies will allow it to better serve the water needsof its global customers.

“By combining Osmonics’ excellent technolo-gy and engineering resources with the comple-mentary capabilities of GE Water, we will createan even broader portfolio of products and ser-vices that we can offer for a wide range of energyand industrial applications worldwide. In addi-tion, we are excited about the commercial syner-gies with GE Betz and GE Consumer Products,”said Rice.

In the merger, Osmonics shareholders willreceive the equivalent of US$17.00 of GE com-mon stock for each share of Osmonics.Shareholders may elect to receive US$17.00 incash per share instead of GE shares, subject toproration, so that the total cash paid does notexceed 55% of the total merger consideration.

The merger, which is subject to the approvalof the holders of a majority of Osmonics’ out-standing common shares, government

approvals and other customary conditions, isexpected to close in the first quarter of 2003.Following the completion of the acquisition,Osmonics will be integrated with GE Water, aunit of GE Power Systems.

“Osmonics has a solid product line with excel-lent opportunities for growth, but we needed theresources of a larger organization to take thecompany to the next level,” said Dean Spatz,chairman and CEO, Osmonics.

GE Water, which is based in Guelph,Ontario, Canada, serves the industrial waterservices market that includes power, semicon-ductors and electronics, petrochemical, oil andgas, pulp and paper, food and beverage, phar-maceutical and health care.

In other, unrelated news, Osmonics MedicalSystems has been launched to market waterpurification systems and related equipment tothe medical dialysis market. The new divisioncombines 30 years of the company’s dialysiswater treatment expertise with the turnkeycapability gained from the acquisition ofZyzaTech during 1999.

Osmonics Medical Systems will combineproven water treatment system designs withcomplete customer care packages in an effortto improve patient safety and comfort, while

reducing the overall cost to the clinic of oper-ating the equipment. The company says anincreased focus on long-term partnershipswith dialysis care providers will be a primaryobjective.

The products are manufactured atOsmonics’ facility in Kent, Washington. JohnRickert, the division’s business manager, saysthat the company also will be expanding itsrange to include 510(k) compliant disinfectionsystems, and mixing and delivery products. Thedivision is aiming to offer providers a singlesource of compliant equipment as well as anongoing service relationship to ensure that allcomponents are well maintained.

For more information, contact: Osmonics Inc,5951 Clearwater Drive, Minnetonka, MN 55343, USA.Tel: +1 952 933 2277, Fax: +1 952 933 0141.

Or contact: GE Power Systems, 4200 WildwoodParkway, Atlanta, GA 30339, USA. Tel: +1 770 8596948, Fax: +1 770 859 7513.

GE Power Systems to broaden product portfolio with Osmonics acquisition

ISSN 0958-2118 /02/$22.00 © 2002 Elsevier Science Ltd. All rights reservedThis journal and the individual contributions contained in it are protected under copyright by Elsevier Science Ltd, and the following terms and conditionsapply to their use:PPhhoottooccooppyyiinnggSingle photocopies of single articles may be made for personal use as allowed by national copyright laws. Permission of the publisher and payment of a feeis required for all other photocopying, including multiple or systematic copying, copying for advertising or promotional purposes, resale, and all forms ofdocument delivery. Special rates are available for educational institutions that wish to make photocopies for non-profit educational classroom use.

Liver dialysis is set to become a reality

C o n t e n t s

News 1

Feature: Hydrogen-based membrane-biofilm reactor solves oxidized contaminant problems 6

Patents 10

Research Trends 14

Events Calendar 15

ISSN 0958-2118 November 2002

Nov memb.qxd 19/11/2002 15:24 Page 1