8/18/2019 Lipoproteins Chart

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Chylomicrons VLDL LDL HDL

Diameter   Biggest Big Medium Small

Composition:

 Triacylglycerols   80-90%   46-65% 10-12% 5%

Phospholipids 7% 13-23% 20-22%   25%

Protein 2% 5-12% 10-22%   50%

  -1 !

  B-100 ! !

  B-"# !

  $- ! ! !

  & ! ! !

ite o" synthesis ntestine 'i(er Blood 'i(er) ntestine

#ransport o"  *ietary T+ &ndogenous T+ $holesterol $holesterol

#ransport to Peripheral tissue Peripheral tissue

'P' 'P' 'P' B$-1

  ,reas T+ into three .atty acids plus glycerol P$T

$&TP

P'TP

$holesterol

  &steri/ed  ree 2%1%

10-13%5-7%

$6-$%8-&0%

1"%%

Peripheraltissue

M peripheraltissue

'ssociate(

)roteins*+n,ymes

8/18/2019 Lipoproteins Chart

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cti(ates P$T4 ligand .or *' receptor

'*' receptor ligand

$hylo assem,ly 6 secretion

cti(ates 'P'

epatic receptor ligand .or chylo) '*'

$on(erts cholesterol to cholesterol ester

 Trans.ers cholesterol and phopholipids .romperipheral tissues to *'

&changes cholesterol ester on *' .ortriglyceride on 8'*'

&changes triglyceride on *' .orphospholipids on 8'*'