lesson fifty-six “hormone replacement”6/... · – estrone, estradiol, estriol – progesterone...

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Spring 2015 Class Lesson Fifty-Six

“Hormone Replacement”

HRTintroduc0on

•  HRTisaverycontroversialtopic•  Difficultformetodiscussasanon-doctor•  Noques;on:HRTcanreduceSx,but…–  Isitneeded?–  Isitsafe,isittoxic,doesitcauseproblems?–  AretherebeFermethods?–  Can“bioiden;cal”hormonesbeusedinsteadofsynthe;cones?(HRTversusBHRT)

–  Let’slookatsomeofthecontroversiesandop;ons…

HRTintroduc0on

•  Theideaistoreplacehormonesthatdeclineaswomenandmengrowolder

•  Ini;ally,itwasdevelopedtoreplaceestrogeninmenopausalwomen–  LudicrousgiventhatPdeclinestoagreaterextent

•  Progesteroneandtestosteronearealsoconsideredthesedays

HRTintroduc0on

•  Bioiden;calhormonescannotbepatented–  Becausethemoleculeoccurwithoutneedingtobemanmade/synthesisedinalab

•  Synthe;chormonescanbepatented•  Hereinliesaclue!–  It’smoreprofitabletothepatentmedicinecompaniesusesyntheUchormones

HRTintroduc0on

•  Nottheplaceforpoli;calcontroversies:–  Getthisbook…–  Otherbooks&resourcesmen;onedinthismodulearealsohelpful•  Collins•  Schwartz•  Lee•  Peat

HistoryofHRT

•  Goesbackalong;me–China,Egypt,etc.•  1960s–firstpatentedsynthe;cestrogen

–  FeminineForever–RobertWilson(1966)

•  Soonunopposedestrogencausesproblems–  Uterinecancer

•  1970s-Synthe;cprogesterone(proges;n)developedtooffsetadverseeffects

•  Combina;ontherapy–PremPro•  Foundthattheycanbothcauseproblems

Terminology-estrogen

•  Intheliterature,“estrogen”isusedinterchangeably,whichcausesalotofconfusion

•  Synthe;cversusmadebythebody?•  Humanestrogenversusequineestrogen?•  Whichestrogen,specifically?(E1,E2,E3)–  Nowonderwomengetconfused!

Terminology-progesterone

•  Progestogens(progestagensorgestagens)aresteroidhormonesthatbindtoandac;vatetheprogesteronereceptor

•  Progesterone–thenaturallyoccurringhormone,madebythebody

•  ProgesUns-synthe;cprogestogens,medica;onsthathaveeffectssimilartothoseofprogesterone

Terminology-products

•  Premarin-brandnameforanestrogenmedica;onconsis;ngofconjugatedestrogensisolatedfromtheurineofpregnantmares(pregnantmares'urine).

•  Provera–aproges;nusedincontracep;onandHRT(medroxyprogesteroneacetate)

•  PremPro–combina;onoftheaboveusedinHRT

ChemicalstructureofProvera

hFp://www.drdach.com/Safety_of_BioIden;cals_0H9.html

WhatarePremarinandProvera?

“Premarin&Proveraarenotbio-idenUcalhormones.Premarinisahormonefrompregnanthorses,which

containsEquilin,ahorsehormonenotfoundinhumans.”hFp://www.drdach.com/Safety_of_BioIden;cals_0H9.html

Note:ThereareFOURTEENtypesofestrogeninmare’surine;only

threeinhumans.

WhatarePremarinandProvera?

“ProveraisasyntheUchormonewhichisnotfoundanywhereinthenaturalworld(seeproveradiagram

below).ThePremarinandProveracombinaUoniscalledPremPro,asyntheUchormonepillcommonlyprescribedbymainstreammedicine.PremprowasthehormonepreparaUonusedinthefirstarmoftheWHIstudy.”

hFp://www.drdach.com/Safety_of_BioIden;cals_0H9.html

TheWHI

•  TheWomen’sHealthIni;a;ve(WHI)–  Largegovernmentstudyofsynthe;chormones–  16,000womenaged50-79–  Hadtobehaltedprematurely3yearsearly– Womenusingsynthe;cHRThadincreasedriskofheartdisease(26%),stroke(41%)andbreastcancer(29%)

TheWHI

•  TheLancet,2003:

“UseofHRTbywomenaged50-64yearsintheUKoverthepastdecadehasresultedinanesUmated20,000extrabreastcancers,15,000associatedwithestrogen-

progestagen;theextradeathscannotbereliablyesUmated.”

hFps://www.ncbi.nlm.nih.gov/pubmed/12927427

TheWHI

•  JohnLeeM.D.

“For30yearsmostwomenhadbeentoldbytheirdoctorsthattheyneededHRTagermenopause,andnowinthewakeofthisnewinformaUonaboutthepotenUaldangersofthistreatment,theywerebeing

toldnottotakeit.”

NaturalHormoneBalanceMadeSimple,page16.

TheWHI

•  WHIcreatedallkindsofconfusion–  Terminologyissues–synthe;cvs.bioiden;cal– Whichhormonesweregood/bad?–  AreALLestrogensandprogesteronebad?– Whatcan/shallwedo?

Nega0veeffectsofPremarinvs.estrogen

•  TheNaturalSuperwoman,pp.70-72:–  Premarinincreasesinflamma;on(CRP)–  Increasesbodyfat–  IncreasesSHBG–  Increasescardiovascularevents–  DecreasesCoQ10andvitaminE–  Increasesmigraines–  Increasesstressincon;nence–  Increasesdry-eyesyndrome

Nega0veeffectsProveravs.progesterone

•  TheNaturalSuperwoman,pp.72-74:–  Proverapromotesbreastcancer–  Promotesdiabetes–  Promotessignificantboneloss–  HarmstheCVsystem–  Decreasessleepquality–  Affectsimmunesystemnega;vely–  Harmsthebrain–neurodegenera;vedisease–  Affectsmood–  Increasesseizures

Nega0veeffectsofproges0ns

•  HormoneBalanceMadeSimple–pp.23-24–  Whydofer;litydoctorsuseprogesteroneandnotproges;ns?–  Whydoproges;nscausebirthdefects,whileprogesteroneisessen;alforaviableandhealthypregnancy?

–  Whydon’tsynthe;cproges;nsshowupinblood&salivatests?–  Whydon’tproges;nsraiseprogesteronelevelsinthebody?–  Whydon’tpregnantwomenmakingmassesofprogesterone,getbreastcancer?

–  Whydoesn’tnaturalprogesteronecausethesideeffectslistedformedroxyprogesteroneacetate(Provera)

TheboEomline

•  TheboFomlineisthat:– Womenneedhormonalsupport–  Itcanbedonewiththebasicsandherbs–  Somewomenneedmore–  HRTisagrey,blurryarea–  Synthe;chormonesareadoubleedgedsword–  Therearecleardangers

Whatarethealterna0ves?

Bioiden0calhormones

•  Bioiden;calhormonesaremadebythebody•  Theyarecallednaturalhormones–  HoweverEVERYTHINGisnatural,so“naturalhormones”isafalseterminmyopinion

•  Theycanbesynthesizedinthelabandusedasbioiden;calhormonetherapy(BHRT)–  Synthesisedfromsoyandwildyam•  Theyhavethesamechemicalstructureasthosemadeinthehumanbody

Bioiden0calhormones

•  ArgumentsforBHRT:–  Saferasmoleculesaresameashumanhormones–  Clinicallyveryeffec;ve

•  Manyintegra;veandfunc;onaldoctors,aswellaspa;ents,aFesttothis.–  Peat,Lee,Reiss,Schwartz,Wright,Holtorf,Gouried,andmanymore

Bioiden0calhormones

•  ArgumentsagainstBHRT:–  UsuallycomefromlobbyistsinBigPharma–  Safetyisnotproven–  Cancauseproblemsifusedunwisely(true)–  Unregulated–availableonline•  Makesthemopentomisuse(whichistrue)

Whichhormonesarewetalkingabout?

•  Sexhormones:–  Estrone,estradiol,estriol–  Progesterone–  TestosteroneAND…adrenal/thyroidhormones:–  Pregnenolone–  DHEA•  Becauseadrenalstakeuptheslackavermenopause

–  Thyroid

WhylimitourselvestoE,P,andT?

•  RemindyourselfofRayPeat’sar;cleonthethreeyouth-associatedhormones:–  Pregnenolone–  DHEA–  Progesterone

•  hFp://raypeat.com/ar;cles/ar;cles/three-hormones.shtml

BHRTaims/goals

•  Aimsoftherapy:– NO:maximisehormonelevels– NO:restorelevelstothoseofa20-yearold•  Thiswouldbesilly!

– YES:safelyop;misequalityoflifeandminimisediseaserisk• Whowouldn’twantthis?

JohnLee’sBHRTrules

•  Rule1–usehormonesonlyifyouneedthem(iftheyaremeasurablylowand/orifyouhavesymptoms)

•  Rule2–Usebioiden;calhormonesratherthansynthe;chormones

•  Rule3–usehormonesonlyindosagesthatcreatehormonebalance

•  Rule4–don’tuseestrogensontheirown!

Deliverymethods

•  Thereareseveraldeliverymethods:–  Transdermalcreamsandgels–  Pillsandlozenges–  Sublingualorintraoraldrops

•  Oiloralcoholbase–  Vaginalapplica;on–  Suppositories

Deliverymethods

•  Clinicianshavebiastowardsdeliveryop;ons•  Usuallybasedonwhattheyhaveaccessto•  Inturn,thisisbasedontheirqualifica;ons

–  E.g.Dr.KalishandReedDavisrecommendedsublingualdropsontheirtrainingcourses–pregnenolone,progesterone,DHEA

Deliverymethods

•  Creams:–  Mayaccumulateunderskinandcauseexcess–  Mayrequireever-increasingdosetomaintaineffects

•  Oral–pills/lozenges:•  Gotoliverfirst–unnatural?

–  OralEcausesliverinflamma;on(Dr.Wright)–  OralPseemstobesafe(Dr.Wright

•  Sublingual:•  Causesrapidspikeanddropinhormonelevel

•  Membraneapplica;on(labia,clitoris):–  E,T,DHEAforwomen–  Tinclitorisenhancesorgasms(Dr.Wright)

Compoundingpharmacies

•  Somedoctorsworkwithcompoundingpharmacies–  SeehistoryofdevelopmentfromJonathanWrightvideo

•  Individualisedformulasbasedonlabresults–  Problemisthatwhenyouincreaseyourdose,youincreaseallingredientsintheformula

Bi-estandTri-est

•  NaturalestrogencreamsfirstcreatedbyJonathanWrightM.D.–  Bi-est=estradiolandestriol–  Tri-est=allthreeestrogens–  Accessviacompoundingpharmacy

Myexperience/legali0es

•  Myexperience:–  Ihaveusedbioiden;calhormoneswithquitealotofU.S.basedclients(maleandfemale)•  Goodsuccessinmanycases,thoughIhaveseenhowproblemscandevelop

–  ProductsareavailableOTCandontheInternet–  Legally,itisverydifficulttouseBHRTintheUK,Australia,Canada,etc.

Trans-oralprogesterone

•  Progest-EComplex-RayPeat

•  Oil-based•  Rubbedintothegums•  AlsocontainsvitaminE•  Mustbekeptrefrigerated–  Iusethismyself–it’sgreatforsexdriveinmen;-)

Trans-oralprogesterone

•  Progesterone(3mg/drop),non-GMOmixedtocopherols,andnon-GMOMCToilfrompurecoconut.–  Doesnotrequirerefrigera;on

Trans-dermalprogesteronecream

•  Contains450mgofUSPProgesteroneperounce(20mgper1/4teaspoon).

Oil-basedtransdermalprogesterone

•  Topicaloil-basedbioiden;calprogesterone

•  Topicaluseonly

–  NOTE:Theyusedtodo;nypellets(Isocort,too,whichwasactuallycor;sol)

Oil-basedtransdermalestradiol

•  Topicaloil-basedbioiden;calestriolandprogesterone

•  Topicaluseonly–  Post-menopausalassistancewithvaginaldryness

Trans-dermalestriolcream

•  EachounceofEstriolCreamcontains18mgofUSPEstriol

•  0.75mgofestriolper1/4tspofcream.–  Post-menopausalassistancewithvaginaldryness

LiposomaltransdermalE3/progesterone

•  LiposomalE3/Pcombo:–  Eachfullpressofthepumpprovidesapprox0.75mgEstriolUSPand20mgProgesteroneUSP.

–  Estro-Progensaisformulatedtocontain18mgofEstrioland480mgofProgesteroneperounce.

Transdermalpregnenolone

•  15mgperpumpofnaturalpregnenolone–  Idon’tknowwhattheefficacyofcreamislikeforpregnenolonedelivery…

Pregnenolonepowder

•  NaturaHealth(seeresourcesforthislesson)–  “RayPeatsupplies”–  Powdercomesindifferentsizes

–  Theyalsosellweighingscalesforprecisedosing

Sublingualdrops(alcohol-based)

•  Sublingualpregnenolone

•  Inalcoholbase•  Droppedundertongue•  Tightdosage;tra;on–  Irritatesgumsinsomepeople

Sublingualdrops(alcohol-based)

•  SublingualDHEA•  Inalcoholbase•  Droppedundertongue•  Tightdosage;tra;on–  Irritatesgumsinsomepeople

Sublingualprogesterone

•  Alcoholbasedversionofprogesteroneserum–  Specialneedsorsensi;vi;estomixedtocopherols(vitaminE)orMCTcoconutoil.

–  Twoingredientsalcoholandprogesterone.

Pillsandcapsules

•  ManufacturersmakepregnenoloneandDHEAcapsules

•  Idon’thaveexperiencewiththem,socannotcommentonqualityandefficacy:–  hFps://uk.iherb.com/search?kw=pregnenolone–  hFps://uk.iherb.com/search?kw=DHEA

Testosterone

•  AsfarasIknow,theonlywaysomeonecangettestosteroneisthroughadoctor.–  Canbeappliedtothelabia,clitoris–  Canbeappliedtothescrotum–  Canbecompoundedwithotherhormones

Contraindica0ons/sideeffects

•  Clienthistoryiscomplex–cancer,cardiovascular•  You’renotadoctor,orqualifiedtorecommendtheseproducts

•  You’renotconfident,evenifyou’relegallyallowedtorecommend(e.g.U.S.market)


“SomethingveryfewwomenwillfeelwhenusingeventhesmallestdosesofP.Theirbloodpressurefalls,theyhypervenUlate,theyfeelpanicked,andtheirpulserises.Thesewomenmayhavechronicviralsyndrome,Lyme,toxiceffectsofblackmoldandheavymetals,severeenvironmentalallergies,oranincreaseofyeast

overgrowth.”

TheNaturalSuperwoman–p.121.


•  Femaleearly20s:– Extremeanxiety,ADHDtypesymptoms– 24dropsBiomatrixpregnenolone/dayasperBiohealth/KalishstageIIadrenalfa;gueprotocols

– Calmeddowninstantly


•  Female,early40’s:– Lowenergy,hypo-metabolismsymptoms(depressed,etc.)

– ONEdropofBiomatrixpregnenolone– Anxious,hyper-response,couldn’tsleepfor24hours

Resources

•  Dr.JohnLee’sbooks•  Dr.JonathanWright’sbooks•  Dr.UzziReiss’books•  Chapter9–TheHormoneSolu;on(Schwartz)•  NicesummarybyD.rDachonline

–  hFp://www.drdach.com/Safety_of_BioIden;cals_0H9.html

•  NiceYouTubevideobyDr.Wright–  hFps://www.youtube.com/watch?v=hLxv2XQfCxk

HRTandBHRT-summary

•  It’sverycontroversial•  HRTcanimprovequalityoflife,butitcanalsokill!•  BHRTmakessense,butit’snot100%safe•  It’salsonotsimple:

–  Whichhormones,whatdeliverysystem,whatdosages?•  SomewomenmightNEEDBHRT

–  Itcouldbealife-saverforthem:literally•  Youhavetoknowwhatyou’redoing•  Monitoratall;mes•  Don’tevengothereifyouarelawfullynotallowed•  Findsomeonewhocanhelp

ThankYou!

•  Asalways,thanksamillionfortuninginandconsumingthisinfo.It’sbeenmypleasuresharingthiswisdomwithyou.Inthenextlessonwe’regoingtolookatsomecasestudies.

lesson fifty-six “hormone replacement”6/... · – estrone, estradiol, estriol – progesterone...

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