lectures on computational biology hc lee computational biology lab center for complex systems &...
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Lectures on Computational Biology
HC LeeComputational Biology Lab
Center for Complex Systems & BiophysicsNational Central University
EFSS IINational DongHua University
Hualien, 2002 July 1-5
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What is Computational Biology?The use of computational techniques to model biological
systems at various levels of complexity - atomic, metabolic, cellular and pathologic.
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Central dogma for molecular biology
DNA
RNA
Protein
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Yeast alanyl transfer RNA
DNA
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StandardGenetic
Code
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Amino acid codes Name, 3-letter and single-letter codes
Aspartic Acid Asp D Glutamic Acid Glu E Phenylanine Phe F Glycine Gly G Alanine Ala A Cystine Cys C Histidine His H Isoleucine Ile I Lysine Lys K Leucine Leu L Methionine Met M Asparagine Asn N Proline Pro P Glutamine Gln Q Arginine Arg R Serine Ser S Threonine Thr T Valine Val VTryptophan Trp W Tyrosine Tyr Y
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A protein cartoon Sperm whale myoglobin (1MBN)
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The Protein Folding Problem
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Central Paradigm
Central paradigm for Bioinformatics
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Lecture 1
Sequence Alignment
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Lecture 2
Hidden Markov Model
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Lecture 3
Molecular Evolution and Phylogeny
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Lecture 4
Microarray & Analysis