Lasers for Medical

Superior Reliability & Performance

CO2/Excimer/Semiconductor Diodes/OPSL/Fiber Components

Serving the

Medical Community40 Years of History and Experience in Medical Serving the medical laser and photo-medicine community has been an element of Coherent’s culture since its inception. For more than 40 years, Coherent has been a pioneer in the development of lasers for use in the advancement of medicine. While our beginnings were in ophthalmology and later, in the development of both surgical and aesthetic treatments, today we partner with medical system builders across the globe to help people live fuller and more satisfying lives. We do this by bringing advanced cost effective photonic solutions, including lasers and beam delivery components, to medical equipment providers in the therapy areas we serve.

Our focus is to develop enabling laser technologies that are designed to improve current medical treatments, and to enable new ones.

Laser Tissue InteractionLaser use in the field of medicine is large and steadily growing. This growth is based on the versatility of laser light. The characteristics of laser light are defined by its wavelength, pulsed or continuous wave operation as well as its average power. The unique capabilities to tailor laser light to a particular application opens up a wide space for laser tissue interaction. These interactions can be classified into three main categories:

Photothermal Reactions: Laser light absorbed by chromophores in the tissue is converted into heat. A typical application is photocoagulation, where the laser light is absorbed by hemoglobin to stop bleeding or to seal blood vessels. Another example is thermal ablation when laser light vaporizes tissue water for tissue cutting. This interaction requires laser solutions that have high average power and a wavelength that matches the absorption levels of target tissue.

Photochemical Reactions: Photons absorbed by tissue molecules. Excited molecules can undergo chemical reactions. A prominent example is Photodynamic therapy (PDT) where a photosensitive drug is administered. Using specific wavelengths enables applications such as selective photo thermolysis. Tattoo removal is an example of this. This interaction requires laser solutions that have high average power and a wavelength defined by molecule absorption.

Photoablation: Laser light is used to break the molecular bonds in the tissue. Key applica-tions include ophthalmology where UV laser light is used for refractive sur-gery of the cornea, as well as in lithotripsy where high energy laser pulses are used to generate plasma and shock waves that can break up kidney stones. Typical laser solutions operate in pulsed mode for high peak power and, depending on the type of tissue, have UV to NIR wavelengths.

Medical Applications Served Today

Ophthalmology: In Ophthalmology, historically a core segment for us, we cover a wide range of applications. In the field of refractive surgery, we supply excimer laser based solutions for vision correction (LASIK). As a supplier of the majority of laser systems worldwide, we are closely connected in this growing market. In retinal applications we pioneered laser solutions for photo- coagulation, an important application to treat wet form age related macular degeneration (AMD). Our recent innovation utilizes our unique Optically Pumped Semiconductor Lasers (OPSL) and allows OEM customers access to wavelengths that are optimal for photocoagulation. Yellow light couples effectively with hemoglobin which enables more efficient sealing of blood vessels (photocoagulation). Accordingly, this offers a more controlled healing effect and better patient comfort due to minimized heat- load. The direct modulation capability of OPSL enables us to use pulsing modes proven beneficial in recent applications.

Our OEM customers use all of the funda-mental methods in a broad range of medical disciplines, and we provide a broad range of laser and photonics solutions to enable effective medical procedures.

Surgical: For surgical applications, our CO2 lasers are used in a number of laparoscopic applications. Fiber based beam delivery systems for urology applications enable the quick deployment of laser technologies in surgery. Our custom fiber delivery solutions are a key component in laser liposuction. Here we supply specialty custom fiber assemblies that are then converted into consum-able products by our OEM customers.

Dermatology: In the field of dermatology we serve a number of appli-cations. Our CO2 lasers and semiconductor diode lasers are widely adopted in the areas of tattoo removal and hair removal, and our waveguide technology with CO2 lasers is the leading technology in the rapidly growing fractional skin resurfacing application. More recently, system builders have begun to use our visible OPSLs in the treatment of pigmentation, blood vessels or wrinkles because of its better absorption of yellow wavelengths in melanin compared to legacy green laser solutions.

Dentistry: In dentistry we supply near infrared diode lasers for soft tissue applications such as gum surgery. Our laser solutions in this field range from diode bar level systems to higher integrated subsystem solutions.

Medical Device Manufacturing:Another area we are involved in is medical device man-ufacturing. These medical devices encompass a broad range of solutions that host a variety of different laser sources from the UV to mid IR wavelength spectrum. Using the right wavelength for a specific material

provides efficient machining and throughput. Defined by the level of precision needed, we provide solutions from short pulse (nanoseconds) to ultrashort pulses (picoseconds). Ultrashort pulses minimize heat affect-ed zones and with “cold machining” offer the highest level of precision beneficial for the most demanding applications such as stent manufacturing.

Diagnostic Applications: Many areas of medical treatment start with diag- nostics. In the area of diagnostic imaging, we translate our know-how of Life Sciences applications and bridge the gap into clinical solutions. This includes low power visible lasers used in flow cytometers, hematology analyzers or retina scanners.

Medical Laser Applications Table: The following table illustrates how our laser portfolio matches to key medical applications.

As a laser supplier to clinical medical equipment providers, we offer a broad portfolio ranging from laser sources and laser systems to components such as detectors and consumables for light delivery. Our customers benefit from the breadth of our core expertise in laser technologies that translate into optimum solutions for medical applications that are both cost efficient and application specific. It is not part of our core business to sell direct to end users.

Solutions Portfolio

Fiber Semiconductor OPSL Excimer CO2 Components Diodes

Dental - Soft and Hard Tissue x

Ophthalmology - Refractive x

Ophthalmology - Photocoagulation x

Hair Removal x

Dermatology and Aesthetics x x

Surgical x x

CO2 Lasers: Our CO2 portfolio focuses on the value of sealed lasers. Using slab laser technology, our lasers offer higher peak powers that dramatically reduce any charring effect resulting in quicker healing times. The pulsing characteristics of our sealed CO2 lasers translate into optimum results. With a portfolio ranging from 20W to the kW level we can match photon density demands needed for practically any medical treatment. In addition to the standard wavelength of 10.6 µm, we are experienced in using other isotopes to achieve additional wavelengths accessible within the CO2 laser spectrum. Customers benefit from our medical CO2 laser portfolio with its superior performance and reliability from developments we do for materials processing with CO2.

Excimer Lasers: Excimer lasers are the leading UV laser solution in the medical market, providing pulse energies at the mJ level and beyond. These lasers are appropriate and required for medical treatment applications we serve. Our more than 30 years of experience in the design and development of excimer lasers is the background for unbeaten uptime of our lasers. We offer customized solutions to ensure the best value in medical applications. Integrated gas supply bottles are available to provide ease of use and integration.

Semiconductor Diodes: As a vertically integrated provider of semiconductor laser diode- based solutions, we offer a full range of options, from single emitters to laser bars and stacks. Solutions range from supplying the unpackaged semiconductor material and mounted configura-tions including heatsink, to hands-off key switch ready solutions. Using GaAs materials with MBE or MOCVD reactor technology, we cover the wavelength range from 785 To 980 nm. With power levels from multiple Watts to multiple kWs, our hard solder technology is optimum for pulsing conditions prevalent in medical applications. Our experienced design and engineering teams support custom packaging, characterization and other develop-ments needed for these applications.

Optically Pumped Semiconductor Lasers: In the late 1990’s Coherent identified the capabilities of a novel concept for a semiconductor based laser that would overcome current solid-state laser limitations of wavelength and power scalability. The Optically Pumped Semiconductor Laser (OPSL), established as the next generation of solid-state laser technology, uses a semiconductor chip instead of a laser crystal as the laser medium. With its fundamental packaging and reliability benefits as an all semiconductor technology, there are more than 20,000 OPSLs installed in Life Sciences and Medical applications through-out the world. The design elegance of OPSLs provide compact and cost efficient solutions for multimode performance in medical therapeutics.

Custom Fiber Solutions: As a vertically integrated organization, we provide custom fiber so-lutions to the medical industry using our own drawing towers and our experienced engineering and design teams. Our business is to provide custom assemblies as a unique value added consumable for surgical applications such as liposuction. Our OEM customers benefit from our dedication to the design, manufacture and com-mercialization of these products as well as from our sophisticated fabrication, modeling and characterization techniques.

Beam Shaping: Delivering the laser light with a spatial beam profile optimized for the individual therapeutic application is a value we offer to drive adoption of innovative photonics solutions. We offer custom beam shaping options such as line beams or flat top profiles taking ad-vantage of a broad range of the structured light solutions and com-ponents we already serve in other market segments today.

Measurement: Controlling the laser light used in any medical therapy area is key to meeting regulatory compliance. Our business is to partner with our customers to ensure the best measurement sensor is selected for production test, field service, and embedding into their medi-cal tool. We work with our customers to create the most reliable and highest performing systems and that includes laser power and energy measurement devices for virtually all lasers. We have tailored several of our products specifically for the unique wavelengths and beam intensities common in medical laser applications. We also develop turn-key laser characterization systems designed specifically for OEM embedded applications.

Future DevelopmentsAs a leading supplier to the medical industry we are committed to new product developments. These developments include expanding our portfolio in areas where they add value for our customers. A recent example is in the area of fibers, where we built expertise from the component and assemblies level all the way up to fiber laser systems. If your application is not addressed by one of the solutions from our current portfolio, we look forward to discussing your needs, and helping you to evaluate new developments and alternative technologies.

Regulatory Compliance: As a leading supplier of photonics solutions we comply with all applicable regulatory requirements. Coherent is an ISO 9001:2000 certified company. Coherent is also ISO 13485 certified in Europe, which specifies protocols for adherence to customer requirements and product improvement within the European regulatory framework for medical devices. We have signifi-cant experience in supporting our OEM customers with laser engine relat-ed questions regarding FDA and other regulatory clearances. Our primary business model is to supply lasers to medical OEM customers. It is not part of our core business to sell direct to endusers.

Safe Supplier Value: With more than 40 years in business, we operate as a Nasdaq listed public company. You can rely on us being your long term partner and count on the value we bring to your business. Vertical integration on key compo-nents (e.g. semiconductor, crystals) and using quality management prac-tices is the basis for the reliability our products are known for. As a global company with worldwide offices, we provide the logistics and support structure needed by our customers.

Visit the Medical Therapeutics page on our website for more information and latest news:

www.Coherent.com/Medical

Printed in the U.S.A. MC-011-11-1M1210Copyright ©2010 Coherent, Inc.

Coherent as Your Partner.

Coherent, Inc.5100 Patrick Henry DriveSanta Clara, CA 95054phone (800) 527-3786(408) 764-4983fax (408) 764-4646e-mail tech.sales@Coherent.com

www.Coherent.com

To compete and succeed in today’s fast-paced research and manufacturing environments, you needa laser partner who understands your needs. A partner who can provide a wide range of technologysolutions, and the support that goes with them.

Since 1966, Coherent has been helping customers by providing complete laser-based solutions fora wide range of commercial and scientific applications.

With a heritage of innovation and an uncompromising position on quality, Coherent is the mostforward-thinking and diversified manufacturer of solid-state, gas, excimer and semiconductor lasersin the industry.

For more information, visit us on the Web at www.Coherent.com. Or call 800-527-3786.

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