lacosamide overdose

Reactions 1453 - 25 May 2013 O S Lacosamide overdose Fatal poisoning: case report A 56-year-old man developed fatal poisoning after an overdose of lacosamide. The man was admitted to an ICU with lacosamide poisoning. His medical history included hypertension, depression, and epilepsy in relation to an ischaemic stroke 10 years prior; his usual medications included lacosamide. He had ingested 7.0g of lacosamide in an attempt at suicide, and had called a family member. He was found unconscious about 10 minutes later, and presented to hospital with cardiac arrest. The man was administered epinephrine [adrenaline], sodium chloride and sodium bicarbonate, with a spontaneous cardiac rhythm achieved. An ECG revealed junctional rhythm with a QRS of 0.206s, a hemi-left anterior bundle, and complete right branch bundle block. Despite treatment, his condition rapidly deteriorated, he developed refractory distributive shock and multiorgan failure, and died 14 hours after admission. Author comment: "Here, we report a case of fatal overdose related to [the] cardiovascular toxicity of lacosamide". Malissin I, et al. Fatal lacosamide poisoning in relation to cardiac conduction impairment and cardiovascular failure. Clinical Toxicology 51: 381-382, No. 4, May 2013. Available from: URL: http://dx.doi.org/10.3109/15563650.2013.778993 - France 803087258 1 Reactions 25 May 2013 No. 1453 0114-9954/10/1453-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved

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Reactions 1453 - 25 May 2013

O SLacosamide overdose

Fatal poisoning: case reportA 56-year-old man developed fatal poisoning after an

overdose of lacosamide.The man was admitted to an ICU with lacosamide

poisoning. His medical history included hypertension,depression, and epilepsy in relation to an ischaemic stroke10 years prior; his usual medications included lacosamide. Hehad ingested 7.0g of lacosamide in an attempt at suicide, andhad called a family member. He was found unconscious about10 minutes later, and presented to hospital with cardiac arrest.

The man was administered epinephrine [adrenaline],sodium chloride and sodium bicarbonate, with a spontaneouscardiac rhythm achieved. An ECG revealed junctional rhythmwith a QRS of 0.206s, a hemi-left anterior bundle, andcomplete right branch bundle block. Despite treatment, hiscondition rapidly deteriorated, he developed refractorydistributive shock and multiorgan failure, and died 14 hoursafter admission.

Author comment: "Here, we report a case of fataloverdose related to [the] cardiovascular toxicity oflacosamide".Malissin I, et al. Fatal lacosamide poisoning in relation to cardiac conductionimpairment and cardiovascular failure. Clinical Toxicology 51: 381-382, No. 4,May 2013. Available from: URL: http://dx.doi.org/10.3109/15563650.2013.778993- France 803087258

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