The main goal of the research in this laboratory is to

develop innovative strategies for cancer diagnosis and treat-

ment based on the better understanding of the physiology

and biology of tumor microenvironments and cancer-host

interaction.

Research focus;

1)Cancer Nanomedicine(Matsumura& Yasunaga Labora-

tory)

- Development of the next generation of DDS through

fusion between engineering-based nanomaterials and

biomaterials,such as antibodies.

- Elucidation of cancer induced blood coagulation.

- Proposals of the new concept of cancer stromal targeting

(CAST)therapy.

- Development of a non-invasive,doctor-free cancer screen-

ing test using nanotechnology.

- Application of molecular imaging and bioinformatics.

- Development of lymphocyte-targeted diagnosis and treat-

ment.

2)Cancer biology based on the microenvironment context

(Ochiai＆ Ishii Laboratory)

- Generation of in vivo and in vitro models mimicking the

cancer microenvironment by using fluorescence imaging

and time-lapse imaging.

- Clarification of the novel biological mechanisms of can-

cer progression and drug sensitivity based on the mi-

croenvironment context.

- Validation of the obtained results by using human sam-

ples.

3)High-resolution genome-wide analyses of cancer genomics

(Tsuchihara Laboratory)

- Defining the mutational landscape of cancer genome by

next generation sequencing to trace the evolution of

individual cancer genomes to adapt tumor microenviron-

ment.

- Exploration of novel biomarkers based on comprehensive

genomic and epigenomic analyses useful to predict the

prognosis of patients and therapeutic effects of anti-

cancer therapies.

― 25―

Laboratory of Cancer

Biology＋81-4-7133-1111

( )

( )

Ext.5300,aochiai＠east.ncc.go.jp

( )

Ext.5400,yhmatsum＠east.ncc.go.jp

( )

Ext.5794,ktsuchih＠east.ncc.go.jp

( )

Ext.5343,gishii＠east.ncc.go.jp

( )

Ext.5406,mayasuna＠east.ncc.go.jp

［ ］