laboratory ‘network’ update
DESCRIPTION
Laboratory ‘Network’ Update. Max Salfinger New York State Department of Health Princeton October 24, 2006. ‘It is health which is real wealth not pieces of silver and gold’ Mahatma Gandhi, 1869-1948. 3 questions Survey Systems thinking. Adherence/ Cure. 3 Time to negativity?. - PowerPoint PPT PresentationTRANSCRIPT
![Page 1: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/1.jpg)
Laboratory Laboratory ‘Network’ ‘Network’
UpdateUpdate
Laboratory Laboratory ‘Network’ ‘Network’
UpdateUpdateMax SalfingerMax Salfinger
New York State Department of New York State Department of HealthHealth
Princeton October 24, 2006Princeton October 24, 2006
![Page 2: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/2.jpg)
‘‘It is healthIt is health
which is real wealthwhich is real wealth
not pieces of silver and not pieces of silver and gold’gold’
Mahatma Gandhi, 1869-1948Mahatma Gandhi, 1869-1948
![Page 3: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/3.jpg)
•3 questions3 questions•SurveySurvey•Systems thinkingSystems thinking
![Page 4: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/4.jpg)
History / physical examHistory / physical exam
33 Time to negativity? Time to negativity?
Chest x-rayChest x-ray
1 Tuberculosis?1 Tuberculosis?
2 RIF resistance?2 RIF resistance?
Adherence/Adherence/CureCure
seessees
aa
doctordoctor
![Page 5: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/5.jpg)
Nucleic acid amplificationNucleic acid amplification
MicroscopyMicroscopy
Growth detectionGrowth detection
IdentificationIdentification
1.Tuberculos1.Tuberculosisis
yesyes
oror
no no ??
![Page 6: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/6.jpg)
rpoBrpoB analysis (line probes) analysis (line probes)
Clinical courseClinical course
Radiometric / Non-Radiometric / Non-rad.rad.
Agar based ASTAgar based AST
Egg based ASTEgg based AST
2. RIF res.2. RIF res.
yesyes
oror
no no ??
![Page 7: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/7.jpg)
DrugDrug 460TB460TB MGITMGIT 7H107H10 7H117H11
INHINH 0.1/0.40.1/0.4 0.1/0.40.1/0.4 0.2/1.00.2/1.0 0.2/1.00.2/1.0
RIFRIF 2.02.0 1.01.0 1.01.0 1.01.0
EMBEMB 2.5/7.52.5/7.5 5.05.0 5.0/105.0/10 7.57.5
SMSM 2/62/6 1/41/4 2/102/10 2/102/10
PZAPZA 100100 100100 N/AN/A N/AN/A
Testing Testing concentrations:concentrations:
![Page 8: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/8.jpg)
What gets What gets captured in the TB captured in the TB database?database?•Result - susceptible; resistant?Result - susceptible; resistant?
•Method - BACTEC 460; MGIT, Method - BACTEC 460; MGIT, etc?etc?
•Concentration tested?Concentration tested?
•Percent resistant colonies?Percent resistant colonies?
•Mutation found, type?Mutation found, type?
![Page 9: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/9.jpg)
3. Time to negativity3. Time to negativity•Follow up specimens until 2 Follow up specimens until 2 consecutive specimens are culture consecutive specimens are culture negative... negative...
•Initial cavitation & Initial cavitation & mo-2mo-2 culture culture pos: extend INH/Rif from 4 to 7 pos: extend INH/Rif from 4 to 7 monthsmonths
•Repeat susceptibility testing after Repeat susceptibility testing after 3 mo3 mo
•Pos culture @ Pos culture @ mo-4mo-4: Treatment : Treatment failurefailure
![Page 10: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/10.jpg)
Survey [N=11]Survey [N=11]::CT, DE, IN, MA, CT, DE, IN, MA,
MI, NJ, NYC, MI, NJ, NYC, NYS, PA, VT, WVNYS, PA, VT, WV
![Page 11: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/11.jpg)
NAANAA::
YES: 6YES: 6NO: 5NO: 5
![Page 12: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/12.jpg)
DSTDST::
Bactec 7Bactec 7MGIT 2MGIT 27H10, ESP ea 17H10, ESP ea 1
![Page 13: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/13.jpg)
DST - screeningDST - screening::
SIRE-PZA 5SIRE-PZA 54 drugs 44 drugs 43 drugs 13 drugs 1
![Page 14: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/14.jpg)
DST - 2nd-lineDST - 2nd-line::
YES 6YES 6NO 5NO 5
![Page 15: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/15.jpg)
QuantiferonQuantiferon::
YES 2YES 2NO 9NO 9
![Page 16: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/16.jpg)
Work daysWork days::
7 days: 17 days: 16 days: 16 days: 15 days: 85 days: 8
![Page 17: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/17.jpg)
Biggest concernsBiggest concerns::•Not enough resourcesNot enough resources•Federal TB grant reductionFederal TB grant reduction•Gamma Interferon assays: PHL or hospital-based labsGamma Interferon assays: PHL or hospital-based labs•Ability to keep high level of testingAbility to keep high level of testing•Delayed delivery of specimens and isolatesDelayed delivery of specimens and isolates•Loosing 40+ years of experience (retirement)Loosing 40+ years of experience (retirement)•Staff shortageStaff shortage•Time and moneyTime and money•Maintaining staff competencyMaintaining staff competency•Reduction of Federal $$$Reduction of Federal $$$
![Page 18: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/18.jpg)
Success storiesSuccess stories::•FAST TRACK programFAST TRACK program•Being a member of the LIMS RFQBeing a member of the LIMS RFQ•Moving into better lab spaceMoving into better lab space•Implementation of NAA (homeless case)Implementation of NAA (homeless case)•NAA turnaround timeNAA turnaround time•Staff cross-trainingStaff cross-training•Surpassing CDC turnaround time guidelinesSurpassing CDC turnaround time guidelines•Improving TAT & client relationship with less staffImproving TAT & client relationship with less staff•Molecular identification and drug susceptibilityMolecular identification and drug susceptibility
![Page 19: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/19.jpg)
![Page 20: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/20.jpg)
Systems Systems ThinkingThinking ‘‘We tend to focus on We tend to focus on
snapshots of isolated parts of snapshots of isolated parts of the system, and wonder why the system, and wonder why our deepest problems never our deepest problems never seem to get solved.’seem to get solved.’
Peter Senge in The Fifth Discipline, 1990Peter Senge in The Fifth Discipline, 1990
![Page 21: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/21.jpg)
Did you hear Claudia’s Did you hear Claudia’s husband?husband?
![Page 22: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/22.jpg)
If you suspect If you suspect DRDR, , MDRMDR, or , or XDRXDR TBTB
you have a moral you have a moral responsibility to responsibility to get the results in get the results in the the shortestshortest TAT TAT
possible!possible!
![Page 23: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/23.jpg)
$$$$$$
![Page 24: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/24.jpg)
![Page 25: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/25.jpg)
??
![Page 26: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/26.jpg)
Laboratory Laboratory standardsstandardsNew YorkNew York: NAA : NAA mandatory for newly mandatory for newly diagnosed patients diagnosed patients whose sputum tested whose sputum tested AFB smear positive.AFB smear positive.
![Page 27: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/27.jpg)
Reference Reference Laboratory Laboratory
SystemSystem
![Page 28: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/28.jpg)
Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change Change
![Page 29: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/29.jpg)
TT BBTThinkhink BigBig
![Page 30: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/30.jpg)
BeBeBold !Bold !
![Page 31: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/31.jpg)
Picasso: Peace DovePicasso: Peace Dove
![Page 32: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/32.jpg)
![Page 33: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/33.jpg)
WEWE can do it ! can do it !
![Page 34: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/34.jpg)
Thank YOUThank YOU
forfor
Working Working TOGETHER!TOGETHER!
![Page 35: Laboratory ‘Network’ Update](https://reader036.vdocuments.us/reader036/viewer/2022062804/56814b54550346895db84cf4/html5/thumbnails/35.jpg)
The Journey The Journey sets the sets the
DestinationDestination
see you ALL in see you ALL in Tallahassee, FL Tallahassee, FL
!!