lab. for applied physiology university of tokushima application of nirs to measure muscle metabolism...
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Lab. for Applied PhysiologyUniversity of Tokushima
Application of NIRS to Measure Muscle Metabolism and Vessel
Function
H Miura Ph.D.
First encounter
’98 ~ ’99 at BC’s Lab.
1) Brain function2) Cancer detection3) Muscle metabolism4) Cesarean detection5) Developing device etc
Diagram for functional NIR imager
AmplifierAmplifier
Sensor ● light source■ photodetector
A/D BoardA/D Board
LampController
LampController
Miura et al. Jpn J Phys Fitness Sports Med 2000
COGNOSCOPE NIM INCORPORATED
Measurement of muscle metabolism by functional NIR imaging device
0.2
0.0
-0.2
Exercisedeoxygenation
oxygenation
0.2
0.0
-0.2
Recoverydeoxygenation
oxygenation
Right Leg
0.2
0.0
-0.2
Restdeoxygenation
oxygenation
(o.d.)
Oxygen saturation during standing plantar flexion in gastrocnemius muscle
Miura et al. Jpn J Phys Fitness Sports Med 2000
0.2
0.0
-0.2
Exerciseincrease
decrease
0.2
0.0
-0.2
Recoveryincrease
decrease
Right Leg
0.2
0.0
-0.2
Restincrease
decrease
(o.d.)
Blood volume during standing plantar flexion in gastrocnemius muscle
Miura et al. Jpn J Phys Fitness Sports Med 2000
What’s next?
Exercise Recovery
Right Leg
Miura et al. Jpn J Physiol 2001
Rest
0.2
0.1
0.0
-0.1
-0.2
deoxygenation
oxygenation
(o.d.)
Oxygen saturation during standing plantar flexion in medial head of gastrocnemius muscle
Exercise Recovery
Right Leg
Rest
0.2
0.1
0.0
-0.1
-0.2
increase
decrease
(o.d.)
Miura et al. Jpn J Physiol 2001
Blood volume during standing plantar flexion in medial head of gastrocnemius muscle
What’s next?
oxy
-Hb
(μ
mol
)
●: PVD ● : Healthy
(sec)occlusion recovery
-30
-20
-10
0
10
20
30
0 100 200 300 400 500 600
Miura H, Okumura N Adv Exp Med Biol 2010
Change of oxygeation during thigh occlusion test
Re
cove
ry ti
me
(se
c)
healthy 1 2 3 4 5 60
20
40
60
80
100
The larger number indicates the more severe of PVD
PVD
Recovery time in PVD patients and healthy subjects
Miura et al. Spectroscopy 2002
0
20
40
60
80
100
Re
cove
ry ti
me
(se
c)
healthy 1 2 3 4 5 6
#5’ and #6’ indicate the data after taking medication
5’ 6’
PVD
Recovery time in PVD patients and healthy subjects
Miura et al. Spectroscopy 2002
oxy
-Hb
(o.
d.)
■: Hypertensive group ■ : Healthy group
(sec)
-0.03
-0.02
-0.01
0.00
0.01
0.02
0.03
0 20 40 60 80 100 120 140 Rest Cold Pressor Test
Miura et al. JJCA 2011
Change of oxy-Hb during cold pressor test
Prospect of NIRS
1) Owing to Chance’s great achievements, improvements in NIRS have matured this technique to be applicable for a wide range of applications2) NIRS is still prospective technology and in the future this kind of tool might play a crucial role in diagnosing, treating some diseases, or defining therapy process
My BC’s memory
Toward research, Britton Chance was strict and showed no willingness to compromiseBritton Chance will be greatly missed as a great scientist in exercise physiology and clinical medicine
With deepest regret, Hajime Miura
