kristinamarieturnergossypolblastmatchsequencehomology

Upload: kristina-turner

Post on 08-Apr-2018

218 views

Category:

Documents


0 download

TRANSCRIPT

  • 8/6/2019 KristinaMarieTurnerGossypolBLASTMatchSequenceHomology

    1/24

    Kristina Turner, M.S.

    Gossypol BLAST Match Sequence Homology

    >Gossypium-hirsutum_ (+)-delta-cadinene synthase (D-cadinene synthase)

    MASQVSQMPSSSPLSSNKDEMRPKADFQPSIWGDFFLNCPDKNIDAETQKRHQQLKEEVRKMIVAPMANSTLKLAFIDSVQGLGVSYHFTKEIEDELENIYHNNNDAENDLYTTSLRFR

    LLREHGFHVSCDVFNKFKDEQGNFKSSVTSDVRGLLELYQASYLRVHGEDILDEAISFTS

    NHLSLAVASLDHPLSEEVSHALKQSIRRGLPRVEARHYLSVYQDIESHNKVLLEFAKIDFNMVQLLHRKELSEISRWWKDLDFQRKLPYARDRVVEGYFWISGVYFEPQYSLGRKMLT

    KVIAMASIVDDTYDSYATYEELIPYTNAIERWDIKCIDELPEYMKPSYKALLDVYEEMEQ

    LVAEHGRQYRVEYAKNAMIRLAQSYLVEARWTLQNYKPSFEEFKANALPTCGYAMLAITSFVGMGDIVTPETFKWAANDPKIIQASTIICRFMDDVTEHKFKHRREDDCSAIECYMEE

    YGVTAQEAYDVFNKHVESAWKDVNQGFLKPTEMPTEVLNRSLNLARVMDVLYREGD

    GYTYVGKAAKGGITSLLIEPIAL> Vitis-vinifera_ terpene synthase [Vitis vinifera]

    MSVQSSGVLLAPSKNLSPEVGRRCANFHPSIWGDHFLSYASEFTNTDDHLKQHVQQLKE

    EVRKMLMAADDDSAQKLLLIDAIQRLGVAYHFESEIDEVLKHMFDGSVVSAEEDVYTA

    SLRFRLLRQQGYHVSCDLFNNFKDNEGNFKESLSSDVRGMLSLYEATHFRVHGEDILDEALAFTTTHLQSATKHSSNPLAEQVVHALKQPIRKGLPRLEARHYFSVYQADDSHNKALL

    KLAKLDFNLLQKLHQKELSDISAWWKDLDFAHKLPFARDRVVECYFWILGVYFEPQFF

    FARRILTKVIAMTSIIDDIYDVYGTLEELELFTEAVERWDISAIDQLPEYMRVCYQALLYVYSEIEEEMAKEGRSYRLYYAKEAMKNQVRAYYEEAKWLQVQQIPTMEEYMPVALVTS

    AYSMLATTSFVGMGDAVTKESFDWIFSKPKIVRASAIVCRLMDDMVFHKFEQKRGHVA

    SAVECYMKQHGASEQETPNEFPQPVREAWKDINEECLIPTAVPMPILMRVLNLARVIDVI

    YKNEDGYTHFGAVLKDFVTSMLIDPVPI> Populus-balsamifera-subsp.-trichocarpa-x-Populus-deltoides_(-)-germacrene D

    synthase

    MSVEGSAIFSTATVEPNVSRRSAGYSPSIWGDHFLSYATDSMETSDKAEHKKLKEEVKRELMANINKPSQTLDFIDAIQRLGISYHFEIEIDEILREMYKSHCDFDNGDDDDHHHNDLY

    AISLKFRLLRQQGYKISCDVFGKFKNSQGTFNDSLANDTRGILSLYEATHLRVHGDEVLE

    EALVFTTSHLEFLATHSSSPLRAKINHALKQPVRKNIPRLEARHYFSIYQEDPSCSEVLLNFAKLDFNILQKQHQKELSEIANWWKELDFAKKLPFARDRVIECYFWILGVYLEPEYFLA

    RRILTKVIAMTSVIDDIYDVYGTPEELELFTDAIERWEITAVDQLPEYMKVTYKALLDVY

    TEIEENMVTEERSYRVYYAKEAMKNLVRAYYLESKWFHQKHTPTMEEYMAVALVTSGYAMLAATSFVGMGHVVTKDSFDWLFRGPKILKASEIICRLMDDIVSHKFEQKRGHVASS

    IECYMKQHGTTEQETVHEFRKQVTDAWKDLNEEFLHPTAVPMPLLTRMLNLARVIDVV

    YKDEDGYTNAGTVLKDLVSALLIDPVPM> Medicago-truncatula_ wound-inducible putative cytosolic terpene synthase 1

    MSVSVTSSLVAPTPNANSDFSRRSANYHPNIWGDLFIQYVLEPMEFDEIMKQIIMLKEKV

    RQMLVPNVNVTNPSREANLIDSIQRLGLYHHFEQEIGELLRHIDNNHVENGTITLNEDLH

    SIALVFRLLRQQGYHILPDVFKKFKNEQGNFKETLVGDVEGMLSLYEATHMRIHGEEILDDALSFTSLHLEMMTTQLSPSVATKINHSLKRPLFKNLPRLVARHYISTYEEDPSHDATL

    LLLAKLDFNLLQKQHQKEVGDISKWWKDLDFATKLPFARNRIVEAYFWILGVYFEPQY

  • 8/6/2019 KristinaMarieTurnerGossypolBLASTMatchSequenceHomology

    2/24

    SFGRRIMTKVISLASVIDDIYDVYGTIEELQLFTQAIERWDISCMDFLPQYMKFCYKAVL

    DVYEEMEQEMVKEGRAFCVFYAKNEMKRLVQAYFTEAKWFSRNYIPTVDEYMALGIV

    NSGYYLITATSFIGMGCIATEDVFQWLTNNPKIVNASSKIARLMDDIVSNEFEQERGHGASAIECYMNEHGVSREDAVNELSRQVTNAWKDTNEELLDPTEVPKPLLIRVLNLSRVIDV

    LYKDGDCYTNSQGSTKNDIISILLNPCPV

    > Citrus-junos_ terpene synthase [Citrus junos]MSAQVLATVSSSTEKTVRPIAGFHPNLWGDYFLTLASDCKTDDTTHQEEYEALKQEVRS

    MITATADTPAQKLQLVDAVQRLGVAYHFEQEIEDAMEKIYHDDFDNNDDVDLYTVSLR

    FRLLRQQGFKVPCDVFAKFKDDEGKFKASLVRDVHGILSLYEAGHLAIRGEGILDEAIAFTRTHLQSMVSQDVCPNNLAEQINHTLDCPLRRALPRVETRFFLSVYPRDDKHDKTLLKF

    SKLDFNLVQRIHQKELSAITRWWKDLDFTTKLPYARDRIVELYFWIVGTYFEPKYTLAR

    KIMTKTIYTASIIDDTFDAYGFFEELKLFAEAVQRWDIGAMDILPEYMKVLYKALLDTFN

    EIEQDLAKEGRSSCLPYGKEKMQELVQMYFVQAKWFSEGYVPTWDEYYPVGLVSCGYFMLATNSFLGMCDVANKESFEWISRTLRFQQRHQFICRLRNDIVSHQFEQKRGHIASGVE

    CYIKQYGVSAEEVVTVFTEEVENAWKDMNEEFLKPTAFPVALIERPFNIARVIEFLNKKG

    DWYTHSHAIKDQIAAVLRDPVTI

    > Lycopersicon-hirsutum_ 1 sesquiterpene synthase 1MAASSANKSRPLANFHPTVWGYHFLSYTHEITNQEKVEVDEYKETIRKMLVEAPEGSEQ

    KLVLIDAMQRLGVAYHFHNEIETSIQNIFDAPKQNNNLHIVSLRFRLVRQQGHYMSSDVFKQFTNQDGKFKETLTNDVQGLLSLYEASYLRVRDEEILEEALAFTTTHLKSIVSTMSNN

    NNSLKVEVSEALTQPIRMTLPRMEARRYISIYENNDAHNHLLLKFAKLDFNMLQKLHQR

    ELSDLTRWWKDLDFANKYPYARDRLVECYFWILGVYFEPKYSRARKMMTKVLKMTSII

    DDTFDAYATFDELEPFNDAIQRWDANAIDSIPPYMRPAYQAFLDIYSEMEQVLSKKGKLDRVYYAKNEMKKLVRAYFKETQWLNDCDHIPKYEEHMENSLVSGGYMMIPTTCLVG

    MEEFISIETFEWLMNDPLIVRASSLIARAMNDIVGHEVEQERGHVASLIECYMKDYGASK

    QEAYAKFKKDVTNAWKDINKEFFRPTEVPMFVLERVLNLTRAAEPLYKEKDAYTNAKGKLKNMINSILIESVKI

    > Solanum-tuberosum_ vetispiradiene synthase [Solanum tuberosum]

    MNNYQEEDIVRPVADFSPSLWGDRFHSFSLDNQIAGKYAQEIDTLKEQSRLILFASYIRTLAEKLDLIDIVERLGIAYHFEKQIDDMLDQIYKADPNFEAHEYNDLQTLSVQFRLLRQHG

    YNISPKLFSRFQDAKGKFNESLSNDIKGLLNLYEASHVRTHGEDILEEALAFSTAHLESA

    APHLKSPLSKQVTHALDQSLHKSIPRVETRYFISIYEEEEHKNDVLLRFAKLDFNLLQMLHKQELSEVSRWWKDLDFVTTLPYARDRAVECYFWTMGVYAEPQYSQARVMLAKTIA

    MISIVDDTFDAYGIVKELEIYTDAIQRWDISQIDRLPDYMKISYKALLDLYNDYEMELSK

    DGRSDVVHYAKERMKEIVRNYFVEAKWFIEGYMPPVSEYLSNALATSTYYLLTTTSYL

    GMKSANKQDFEWLAKNPKILEANVTLCRVIDDIATYEVEKGRGQIATGIECYMRDYGVSTEKAMEKFQEMAETAWKDVNEGILRPTPVSTEILTRILNLARIIDVTYKHNQDGYTHPE

    KVLKPHIIALLVDSIEI

    > Nicotiana-tabacum_1 cyclase [Nicotiana tabacum]MSQSISPLMFSHFAKFQSNIWRCNTSQLRVIHSSYASFGGRRKERVRRMNRAMDLSSSSR

    HLADFPSTIWGDHFLSYNSEITEITTQEKNEHEMLKEIVRKMLVETPDNSTQKLVLIDTIQ

    RLGLAYHFNDEIENSIQNIFNLSQNSEDDDEHNLYVAALRFRLARQQGYYMSSDVFKQFTNHDGKFKENHTNDVQGLLSLYEAAHMRVHDEEILEEALIFTTTHLESVIPNLSNSLKVQ

    VTEALSHPIRKAIPRVGARKYIHIYENIGTHNDLLLKFAKLDFNMLQKLHRKELNELTSW

    WKDLDRANKFPYAKDRLVEAYFWTVGIYFEPQYSRSRSLVTKVVKMNSIIDDTYDAYA

    TFDELVLFTDAIQRWDEGAMDLLPTYLRPIYQGLLDVFNEMEEVLAKEGKADHIYYAK

  • 8/6/2019 KristinaMarieTurnerGossypolBLASTMatchSequenceHomology

    3/24

    KEMKKVAEVYFKEAEWLNANYIPKCEEYMKHGLVSSTGPMYGIISLVVMEEIITKEAFE

    WLTNEPLILRPASTICRLMDDMADHEVEQQRGHVASFVECYMKEYGVSKQEAYVEMR

    KKITNAWKDINKELLRPTAVPMFILERSLNFSRLADTFLKDDDGYTNPKSKVKDLIASLFVESVDI

    > Citrus-sinensis_1 valencene synthase [Citrus sinensis]

    MSSGETFRPTADFHPSLWRNHFLKGASDFKTVDHTATQERHEALKEEVRRMITDAEDKPVQKLRLIDEVQRLGVAYHFEKEIGDAIQKLCPIYIDSNRADLHTVSLHFRLLRQQGIKIS

    CDVFEKFKDDEGRFKSSLINDVQGMLSLYEAAYMAVRGEHILDEAIAFTTTHLKSLVAQ

    DHVTPKLAEQINHALYRPLRKTLPRLEARYFMSMINSTSDHLCNKTLLNFAKLDFNILLELHKEELNELTKWWKDLDFTTKLPYARDRLVELYFWDLGTYFEPQYAFGRKIMTQLNYI

    LSIIDDTYDAYGTLEELSLFTEAVQRWNIEAVDMLPEYMKLIYRTLLDAFNEIEEDMAKQ

    GRSHCVRYAKEENQKVIGAYSVQAKWFSEGYVPTIEEYMPIALTSCAYTFVITNSFLGM

    GDFATKEVFEWISNNPKVVKAASVICRLMDDMQGHEFEQKRGHVASAIECYTKQHGVSKEEAIKMFEEEVANAWKDINEELMMKPTVVARPLLGTILNLARAIDFIYKEDDGYTHSY

    LIKDQIASVLGDHVPF

    > Capsicum-annuum_sesquiterpene cyclase [Capsicum annuum]

    MASVAVENNVVNHIAEEIIRPVADFSPSLWGDRFLSFSIDNQVETKYAQEIEPLKEQTRSMLLASGRKLSETLNLIDVIERLGIAYHFEKEIDEILDRIYNENSNFEGDVYNEDLCTCRLQ

    FRLLRQHGYNISLKIFSKFLDGNGRLKESLASDVLGLLSLYEASHVRSHGEDILEDALAFSTTHLESATPHLEYPLKEQVRHALEQSLHKGIPRIEIQFFISSVYDKQAIKNDVLLRFAKLD

    YNMLQMLHKQELAEVSRWWKDLNFVNTLPYARDRVVECYFWALGVYYEPQYSQARV

    MLVKTIAMISIVDDTYDAYGTVDELAIYTDVIQRWDIKEIDSLPDYMKISYKALLDLYKD

    YEKEMSRDGRSHVVYYAKERLKELVKSYNIEAKWFIEGHMPPASEYLRNAFVTTTYYYLATTSYLGMKYAKEQQFEWLSKNPKILEGCVTICRVIDDIATYEVEKNRGQLSTGIECM

    RDYSVSTKEAMAKFQEMGESGWKDINEGMLRPTPIPMEFLSRILNLARLVDVTYKHNE

    GYTHPEKVIKPHIIAMVVDSFKI> Medicago-truncatula_wound-inducible putative cytosolic terpene synthase 2

    MSTLTNSNPEIKQRNLADYHPNIWGEYFIQYASESMDLDQNIVAEIDTLKSEVRNMLVA

    KTDEPFAKVKLVDSICRLGVSYHFEKEIDDVLQQVHKSCVENGEVILEDNLCALAVLFRVLRQQGFYVSPNVFTKFKDKQGNFNETLITDVEGMLSLYEASHMIVHEEDILEEALGFTS

    THLESIATQLNHSLAEQVKYASKHPIHKNLPRLEARHYISIYEQDPSHNEILLTFSKLDFN

    LLQSLHQKEFGNICKWWKELDFSSKLPYARDRIVECSFWSLIVYFEPQYPQARKMLSKVNAILSFIDDTYDSYGTIDELELFTEAIERWDIDALNNLPDYMKLLYKSFWNIYKEIEQEMI

    KQGRLYILNYYEKEFKKAVQAYMTEARWLNKNYIPTTEEYMSVSTISCCSTLLILTSYIG

    M

    GDTVIENIFNWLTNEPIIANAAATICRVMDEIVSSEFEHKRGHVCSLLDCYIKQYGMTREAAIQECQKRVAIAWKDINKECLRPTEVPIEFLTRALNFSRFMDVFYTDKDNYTHVEGLM

    KTYIKDVLVDPIPI

    > Artemisia-annua_ beta-caryophyllene synthase QHS1 [Artemisia annua]MSVKEEKVIRPIVHFPPSVWADQFLIFDDKQAEQANVEQVVNELREDVRKDLVSSLDVQ

    TEHTNLLKLIDAIQRLGIAYHFEEEIEQALQHIYDTYGDDWKGRSPSLWFRILRQQGFYV

    SCDIFKNYKKEDGSFKESLTNDVEGLLELYEATYLRVQGEGVLDDALVFTRTCLEKIAKDLVHTNPTLSTYIQEALKQPLHKRLTRLEALRYIPMYEQQASHNESLLKLAKLGFNLLQS

    LHRKELSEVSRWWKGLDVPNNLPYARDRMVECYFWALGVYFEPKYSQARIFLAKVISL

    ATVLDDTYDAYGTYEELKIFTEAIQRWSITCIDMLPEYLKLLYQGVLDIYIEMEEIMGKE

    GKAHHLSYAKESMKEFIRSYMMEAKWANEGYVPTAEEHMSVAFVSSGYSMLATTCFV

  • 8/6/2019 KristinaMarieTurnerGossypolBLASTMatchSequenceHomology

    4/24

    GMGDIVTDEAFKWALTKPPIIKASCAIARLMDDIHSQKEEKERIHVASSVESYMKQYDV

    TEEHVLKVFNKKIEDAWKDITRESLVRKDIPMPLMMRVINLAQVMDVLYKHKDGFTNV

    GEELKDHIKSLLVHPIPI> Cucumis-sativus_ beta-caryophyllene synthase [Cucumis sativus]

    MSSHFPASIMKTNDIYDTKRSLANFHPTIWKEHFLSFTFDDALKVDGGMKERIEKLKEEI

    RMMVIASVQNPLVKLNLVDSIQRLGVSYHFEDEIDQFLEHMYVSYNNSLLFSSNDSQDDDLHISALLFRLLRQHGYRISCDIFLKFMDNNGKFKESLVEDERGILSLYEASHMRGHGEA

    LLEEALEFTTTHLKAYIHLYSNINPNFASEVSNALKLPIRKCVPRVKAREYFEIYQQQPSH

    NETLLTFSKLDFNILQKLHQKEIAEICRWWKDLNVSTNFPFARDRIVECYFWILSIYFEPYFKFGRKILTKVIAMTSIMDDIYDAYGTFEELQLFTLAIKRWDMSMVNLLPQYMKVHYTT

    LLDLFEEMDKGIVNDGISYRSCFGKEAMKRQAESYFKEAEWLNKNYKPKYGEYMEVA

    LASSGYELLSTISFVCMGDIATKEVFEWLFDCPQILKASTTISRLMDDVVSYKFEKEREHI

    VSAVECYMSNHGRSEDETCAELLKQVEDAWKTINECCLHPMNVPMPFLICLLNLTRVMALLYSHEDGYTNSKGRTKLLIQSLLIDPLHL

    > Pogostemon-cablin_patchoulol synthase [Pogostemon cablin]

    MELYAQSVGVGAASRPLANFHPCVWGDKFIVYNPQSCQAGEREEAEELKVELKRELKE

    ASDNYMRQLKMVDAIQRLGIDYLFVEDVDEALKNLFEMFDAFCKNNHDMHATALSFRLLRQHGYRVSCEVFEKFKDGKDGFKVPNEDGAVAVLEFFEATHLRVHGEDVLDNAFDF

    TRNYLESVYATLNDPTAKQVHNALNEFSFRRGLPRVEARKYISIYEQYASHHKGLLKLAKLDFNLVQALHRRELSEDSRWWKTLQVPTKLSFVRDRLVESYFWASGSYFEPNYSVAR

    MILAKGLAVLSLMDDVYDAYGTFEELQMFTDAIERWDASCLDKLPDYMKIVYKALLD

    VFEEVDEELIKLGAPYRAYYGKEAMKYAARAYMEEAQWREQKHKPTTKEYMKLATK

    TCGYITLIILSCLGVEEGIVTKEAFDWVFSRPPFIEATLIIARLVNDITGHEFEKKREHVRTAVECYMEEHKVGKQEVVSEFYNQMESAWKDINEGFLRPVEFPIPLLYLILNSVRTLEVIYK

    EGDSYTHVGPAMQNIIKQLYLHPVPY

    > Hyoscyamus-muticus_ vetispiradiene synthase 1VDNQVAEKYAQEIETLKEQTSTMLSAACGTTLTEKLNLIDIIERLGIAYHFEKQIEDMLD

    HIYRADPYFEAHEYNDLNTSSVQFRLLRQHGYNVSPNIFSRFQDANGKFKESLRSDIRGL

    LNLYEASHVRTHKEDILEEALVFSVGHLESAAPHLKSPLSKQVTHALEQSLHKSIPRVEIRYFISIYEEEEFKNDLLLRFAKLDYNLLQMLHKHELSEVSRWWKDLDFVTTLPYARDRAV

    ECYFWTMGVYAEPQYSQARVMLAKTIAMISIVDDTFDAYGIVKELEVYTDAIQRWDISQ

    IDRLPEYMKISYKALLDLYDDYEKELSKDGRSDVVHYAKERMKEIVGNYFIEGKWFIEGYMPSVSEYLSNALATSTYYLLTTTSYLGMKSATKEHFEWLATNPKILEANATLCRVVDD

    IATYEVEKGRGQIATGIECYMRDYGVSTEVAMEKFQEMADIAWKDVNEEILRPTPVSSEI

    LTRILNLARIIDVTYKHNQDGYTHPEKVLKPHIIALVVDSIDI

    > Solidago-canadensis_ (-)-germacrene D synthase [Solidago canadensis]MAAKQGEVVRPDADYSYHPSLWGDQFLHYDEQEDDQVEVDQQIEILKEETRKEILSSL

    DDPAKHTNLLKLIDVIQRLGIAYYFEHEITQALGHIYNVYGDEWNGGSTSLWFRLLRQQ

    GFYVSCDIFNIYKLDNGSFKDSLTKDIECMLELYEAAYMRVQGEIILDEALEFTKTHLEQIAKDPLRCNNTLSRHIYEALKRPIRKRLPRVDALQYMPFYEQQDSHNKSLLRLAKLGFNR

    LQSLHKKELSQLSKWWKEFDAPKNLRYVRDRLVELYFWVLGVYFEPQYSRSRIFLTKVI

    KMATILDDTYDIHGTYEELEIFTKAVQRWSITCMDTLPDYMKMIYKSLLDVYEEMEEIIDKDGKAYQVHYAKDSMIDLVTSYMTEAKWLHEGHVPTFEEYNSITNLTGGYKMLTTSSF

    VDMPGDIVTQESFKWALNNPPLIKASADVSRIMDDIVGHKEEQQRKHLPSRVEMYMKK

    YHLAEEDVYDLLKQRVEDAWKDLNRETLTCKDIHMALKMRPINLARVIDMLYKNDDN

    LKNVGQEIQDYIKSCFINAISV

  • 8/6/2019 KristinaMarieTurnerGossypolBLASTMatchSequenceHomology

    5/24

  • 8/6/2019 KristinaMarieTurnerGossypolBLASTMatchSequenceHomology

    6/24

    VRRLILDPTMDSNKKLSLIYTVHRLGLTYMFLKEIEAQLDRLFKEFNLEDYVELDLYTISI

    NFQAFRHLGYKLPCDVFNKFKNDDSTTFKESITGDVRGMLGLYESAQLRLKGENILDEA

    SAFAETKLKSLVNTLEGSLAQQVKQSLRRPFHQGMPMVEARLYFSNYQEECSAHDSILKLAKLHFNYLQLQQKEELRIVSQWWKDMRFQETTPYIRDRVPEIYLWILGLYFEPRYSLA

    RIIATKITLFLVVLDDTYDAYATIEEIRLLTDAINRWDIRCYEIQIPEYIRPFYKILLDEYAE

    LEKQLAKEGRANSVIASKEAFQDIARGYLEEAEWTNSGYVASFPEYMKNGLITSAYNVISKSALVGMGEIVSEDALVWYESHPQILQASELISRLQDGVMTYQFERERGQSATGVDSY

    IKTYGVSEKVAIDELKKMIENAWKEINEGCLKPREVSMDLLAPILNLARMIDVVYRYDD

    GFTFPGKTLKEYITLLFVGSSPM> Marrubium-vulgare_putative terpenesynthase-1 [Marrubium vulgare]

    MAAQIETRPFANFSPSPSLWGDQFTKYNSDPQVKEKYSKQIEVLKNEVKSMVTAQGGK

    MVDTINFIDTMERLGIAYHFKDEIEETIQQFFNLNTNYEDEAYDLYTVALHFRLFRQHGH

    PISCDIFGKWIDGNGKFQESLKSDAKGLLSLYEASYLRIHGDTQLDEAIDFATTNLKSMAPNLGSPLRKQVENALVQSLHFGLPRVEARHFISIYEEEQQKNHTLLRFAKLDFNLLQILH

    KEELCELSRWWKELDFISQFPYVRDRIVECFFWSVGMYHEPQYSRARIMLAKSLVMITIL

    DDTFDSYGTIEELELLTEAMQRWDTKDIDGLPEYIKEIYKLMLKIYQQFEEELAMDGKA

    YATHYAIEAYKELTKGYYVEAKWFIRGYVPPFEEYLSNALVTAGSKYLHFSSLLGMKSIMKKDLEWLSTKRKMIVATQTISRLVNDISSYVEKERGQPATGIECYMKDKGVTKEEAM

    DKFYEMATNAWKDSNEECLGLSGNSRDVYIVVLNFNRIMDVTYKNKEDGYTQPEKVLKPHIIALFVDQIDI

    > Ixeris-dentata-var.-albiflora_guaiadiene synthase

    MALVRNNSINGREPVLSPRSLTSPRGLTSPRPLAVQPTPEPVRPLANFPPSIWANRFISFSL

    DNSELEAYANAHEEPKESVRSLITDTTIDASAKLKLIYSVHRLGLSYLYPEEIDAELDQLFKKIDLHHYEQVDLYTISVQFQVFRHHGYKLSSDIFKKFKDTTTGTFTDEVTKDVKGMLS

    LYESAHLRLHGEEILDEALVFTEAQLKKIVSTLEGDLANQVNQVLKRPFHTGMPMVEAR

    LYFNTHEEDVSCYESIVKLAKVHFNYLQLQQKEELRIVSQWWKDMEFQTSVPYIRDRVPEIYLWILGLYFEPYYSRARIIATKITLFLVVLDDTYDAYATIDEIRAITDAINRWEMSAIDL

    LPEYIKPFYRILLNEYDDLEKEYSKDGRAFSVHASKQAFQEIARGYLEEAEWLHNGYV

    ATFPEYMKNGLITSAYNVISKSALVGMGAIADEEALAWYETHPKILKASELISRLQDDVMTFQFERKRGQSATGVDAYIKEYNVSEEVAIKDLMKMIENAWKDINEGCLKPTEVSVA

    LLTPILNLARMIDVVYKFDDGFTFPGKTLKDYITLLFVTPAPSLESC

    > Elaeis-oleifera_ sesquiterpene synthase [Elaeis oleifera]MSSNTMEAHGSTNHSSVPCGGDGTIRFLANFHPTIWGDYFIENYPLPSNLQKSEACIEKR

    REELKVEVMNLLKNANDYLQEMELIDILQRLGVAYHFEKKIDEILSQIFKEHMEDDNLH

    AVALRFRLLRQHGYNMPTNIFIKFKEVDGSFKATLRNDVKGLLSLYEAAYLGIPKDNLL

    DEALNFAKLHLKSMESHMKTPLAVRVLDAFEMPLHRRTTRLEAKNYISIYQQDDGRINVVLELAKLDFHILQSIHREEVRSISMWWKALGLAKKLTFCRDRVVEGYFWILGVYFEPQY

    SRARIYLTKVLALLSIMDDIYDTYGIAEELQAFTEVIRRWDIEAVDQLDEVYKLYFLNLY

    NTFKEFEDELAKEGNSYRVEYLKESVKELSRAYLEEVKWRDEGYVPPLKEYLNVSQISTVHVALSCASFVGMGEEATKEAFDWVTSFPRIIKSSCLIGRLLDDVASNEFEHERKHVSSA

    VHCYIKEHGTSVQEAYEKLRGMIEDEWKIMNQEYLCMTTMPMSLIRPIINLPRMAETVY

    KKCDSYTHSLSTMKDYIMSLLVEPISF> Ricinus-communis_ Casbene synthase, chloroplast precursor

    MALPSAAMQSNPEKLNLFHRLSSLPTTSLEYGNNRFPFFSSSAKSHFKKPTQACLSSTTH

    QEVRPLAYFPPTVWGNRFASLTFNPSEFESYDERVIVLKKKVKDILISSTSDSVETVILIDL

    LCRLGVSYHFENDIEELLSKIFNSQPDLVDEKECDLYTAAIVFRVFRQHGFKMSSDVFSK

  • 8/6/2019 KristinaMarieTurnerGossypolBLASTMatchSequenceHomology

    7/24

    FKDSDGKFKESLRGDAKGMLSLFEASHLSVHGEDILEEAFAFTKDYLQSSAVELFPNLK

    RHITNALEQPFHSGVPRLEARKFIDLYEADIECRNETLLEFAKLDYNRVQLLHQQELCQF

    SKWWKDLNLASDIPYARDRMAEIFFWAVAMYFEPDYAHTRMIIAKVVLLISLIDDTIDAYATMEETHILAEAVARWDMSCLEKLPDYMKVIYKLLLNTFSEFEKELTAEGKSYSVKY

    GREAFQELVRGYYLEAVWRDEGKIPSFDDYLYNGSMTTGLPLVSTASFMGVQEITGLNE

    FQWLETNPKLSYASGAFIRLVNDLTSHVTEQQRGHVASCIDCYMNQHGVSKDEAVKILQKMATDCWKEINEECMRQSQVSVGHLMRIVNLARLTDVSYKYGDGYTDSQQLKQFVK

    GLFVDPISI

    > Arabidopsis-thaliana_ unknown protein [Arabidopsis thaliana]MGSEVNRPLADFPANIWEDPLTSFSKSDLGTETFKEKHSTLKEAVKEAFMSSKANPIENI

    KFIDALCRLGVSYHFEKDIVEQLDKSFDCLDFPQMVRQEGCDLYTVGIIFQVFRQFGFKL

    SADVFEKFKDENGKFKGHLVTDAYGMLSLYEAAQWGTHGEDIIDEALAFSRSHLEEISS

    RSSPHLAIRIKNALKHPYHKGISRIETRQYISYYEEEESCDPTLLEFAKIDFNLLQILHREELACVTRWHHEMEFKSKVTYTRHRITEAYLWSLGTYFEPQYSQARVITTMALILFTALDD

    MYDAYGTMEELELFTDAMDEWLPVVPDEIPIPDSMKFIYNVTVEFYDKLDEELEKEGRS

    GCGFHLKKSLQKTANGYMQEAKWLKKDYIATFDEYKENAILSSGYYALIAMTFVRMT

    DVAKLDAFEWLSSHPKIRVASEIISRFTDDISSYEFEHKREHVATGIDCYMQQFGVSKERAVEVMGNIVSDAWKDLNQELMRPHVFPFPLLMRVLNLSRVIDVFYRYQDAYTNPKLLK

    EHIVSLLIETIPI> Fragaria-vesca_ sesquiterpene cyclase [Fragaria vesca]

    KTMERLGARRYMSIYQDEASYSENLLKLAKLDFNVVQCLHKKELSDILRWYKELDFAR

    RMPFARDRIVELFFWIAGIYFEPEYVFGRHILTKLIKITTVMDDMYDAFGTFEELVILTEAI

    DRWDASCMDQLPDYMQPFYITLLDVIDEVEEELTKQGRSYRIHYAKEIIKNQARLYFAEARWFHEGCTPKMDGYMRVAASSVGNTMLSVVSLVGMGDIITKFEFEWLTNEPKILRAS

    NTIFRLMDDIAGYKFEKERGHVASSIDCYMNEYGVSEQETIDIFNKRIVDSWKDINEEFL

    RPTAAPVPVLNRVLNLTRVVDLLYKRGDAFTHVGKLMKDCIAAMFIDPVPL> Oryza-sativa-(japonica-cultivar-group)_ putative sesquiterpene cyclase 1

    MATSVPSVLLLPVPTCTDMLVSPVEGGDLLHCKPHFDHHPNVWGDYFLTFSPCTPSMLL

    NMKRKAHVSEEQVRRMILECSSGPNLHVKLELVDTLERLCIDYHYEKEIENVLRRVHEEEDDTDNHYDLHTTALRFYLLRKHGYYASPDVFQRFRDEEGNFTRDDNNNGTRSMLSLY

    NAAHLRIHGEEILDDAIVFTRNYLQSVVKHLQSPMADEVCSALRTPLFRRPRRVEARHYI

    SVYDKLPTRNETILEFAKLDFGILQSLYCEELNILTMWWKELQLQDHLSFARDRMVEMHFWMLGVLFEPQYSYGRTMLTKLFIFVSIFDDIYDNYSTLEESKLFTEAIERWDEEAAEELP

    GYMKFFYKKVLTTMKSIETDLKLQGNKHVDYVKNLLIDATRCFYNEVKWRSEGADQV

    AATVEEHLKISVPSSCCMHVPVYAFVAMGNDVTTDDAINWGMAYPKIITSSCIVGRLLN

    DIASHEREQGSSSSSSSTVEACMREHGGITKEEAYAKLRELVEESWMDIAGECLRPAAAQPPPLLEAVVNATRVLDFVYKDDQDAYTHPSSLKDTIHSIYILSV

    > Quercus-ilex_ putative chloroplast terpene synthase [Quercus ilex]

    MALKLLTSLPMYNFSRVPVSSKDPILLVTSRTRNGYLARPVQCMVANKVSTSPDILRRSANYQPSIWNHDYIESLRIEYVGETCTRQINVLKEQVRMMLHKVVNPLEQLELIEILQRLG

    LSYHFEEEIKRILDGVYNNDHGGDTWKAENLYATALKFRLLRQHGYSVSQEVFNSFKD

    ERGSFKACLCEDTKGMLSLYEASFFLIEGENILEEARDFSTKHLEEYVKQNKEKNLATLVNHSLEFPLHWRMPRLEARWFINIYRHNQDVNPILLEFAELDFNIVQAAHQADLKQVSTW

    WKSTGLVENLSFARDRPVENFFWTVGLIFQPQFGYCRRMFTKVFALITTIDDVYDVYGT

    LDELELFTDVVERWDINAMDQLPDYMKICFLTLHNSVNEMALDTMKEQRFHIIKYLKK

    AWVDLCRYYLVEAKWYSNKYRPSLQEYIENAWISIGAPTILVHAYFFVTNPITKEALDC

  • 8/6/2019 KristinaMarieTurnerGossypolBLASTMatchSequenceHomology

    8/24

    LEEYPNIIRWSSIIARLADDLGTSTDELKRGDVPKAIQCYMNETGASEEGAREYIKYLISA

    TWKKMNKDRAASSPFSHIFIEIALNLARMAQCLYQHGDGHGLGNRETKDRILSLLIQPIP

    LNKD> Zea-mays_ putative sesquiterpene cyclase [Zea mays]

    MAAPTLTADGPRLGQQEMKKMSPSFHPTLWGDFFLSYEAPTEAQEAQMREKAAVLKE

    EVRNMIKGSHDVPEIVDLIITLQRLNLDYHYEDEINEKLTVVYKSNYDGGNLDLVSRRFYLLRKCGYDVSSDVFLKFKDQLGNFVEADTRSLLSLYNAAFLRIHGETVLDEAISFTMRV

    LQDRLEHLESPLAEEVSSALDAPLFRRVGTLEMKDYIPIYEKDAKQNKSILEFAKLNFNL

    LQLRYSSELKECTTWWKELRVESNLSFVRDRIVEVYFWMSGGCYDPQYSHSRIILTKIVAFITILDDTLDSHATSCESMQLAEAIERWDESAVSLLPEYMKDFYMYLLKTFSSFENELG

    PDKSYRVFYLKEAVKELVREYTKEIKWRDEDYVPKTLKEHLKVSLISIGGTLVLCSAFV

    GMGDVVTKKIMKWVMSDAELVKSFGIFVRLSNDIVSTKREQREKHCVSTVQCYMKQH

    EITMDEACEQIKELTEDSWKFMIEQGLALKEYPIIVPRTVLEFARTVDYMYKEADKYTVSHTIKDMLTSLYVKPVLM

    > Mentha-x-piperita_ cis-muuroladiene synthase [Mentha x piperita]

    MATNGVVISCLREVRPPMTKHAPSMWTDTFSNFSLDDKEQQKRSETIEALKQEARGML

    MAATTPLQQMTLIDTLERLGLAFHFETEVEYKIEQINAAAEDDGFDLFATALRFRLLRQHQRHVSCDVFDKFVDKDGKFEESLSNNVEGLLSLYEAAHVGFREERILQEAVNFTRHHLE

    GAELDQSPLLIREKVKRALEHPLHRDFPIVYARLFISIYEKDDSRDELLLKLSKVNFKFMQNLYKKELSQLSRWWNTWDLKSKLPYARDRVVEAYVWGVGYHYEPQYSYVRMGLAK

    GILIIGIMDDTYDNYATLNEAQLFTQVLDKWDRDEADRLPEYMKIVYEFILSTCENYERD

    AAKLGKSFAAPYFKETVKQLARAFNQEQKWVMERQLPSFQDYVKNSEKTSCIYTMFAS

    IIPGLKSVTQETIDWIKSEPTLATSTGMIGRYWDDIGSHLRESKGGEMLTALDFHMKEYGLTKEEAASKFEGLVEETWKDINKEFIATTNYNVGREIAITFLNYARICEASYSKTDGDAY

    LDPNVAKANVVALFVDAIVF

    > Hyoscyamus-muticus_ vetispiradiene synthase 2 - Hyoscyamus muticus(fragment)

    LHKSIPRVETRYFITIYEEEELKNDVLLRFAKLDFNLLQMLHKQELTEVSMWWKDLDFV

    TTLPYARDRAVECYFWTVGVYAEPQYSEARVMLAKTIAMISIVDDTFDAYGIVKELEVYTDAIQRWDINQIDRLPDYMKISYKVLLDLYKDYETELSKDGRSEVVHYAKERMKEIVRN

    YFVEAKWFIEGYMPPVSEYLNNRLATSTYYLLTTTSYLGMKCANKEDFEWLTKNPKILE

    ANVTLCRVIDDIATYEVEKGRGQIATGIECYMRDYGVSTEEAMEKFQEMAEIAWKDVNEGILRPTPVSAKILTRILNLARIIDVTYLHNQDGYTHPEKVLKPHIIALVVDSIEI

    > Pueraria-montan-var.-lobata_ isoprene synthase

    MATNLLCLSNKLSSPTPTPSTRFPQSKNFITQKTSLANPKPWRVICATSSQFTQITEHNSR

    RSANYQPNLWNFEFLQSLENDLKVEKLEEKATKLEEEVRCMINRVDTQPLSLLELIDDVQRLGLTYKFEKDIIKALENIVLLDENKKNKSDLHATALSFRLLRQHGFEVSQDVFERFKD

    KEGGFSGELKGDVQGLLSLYEASYLGFEGENLLEEARTFSITHLKNNLKEGINTKVAEQ

    VSHALELPYHQRLHRLEARWFLDKYEPKEPHHQLLLELAKLDFNMVQTLHQKELQDLSRWWTEMGLASKLDFVRDRLMEVYFWALGMAPDPQFGECRKAVTKMFGLVTIIDDVY

    DVYGTLDELQLFTDAVERWDVNAINTLPDYMKLCFLALYNTVNDTSYSILKEKGHNNL

    SYLTKSWRELCKAFLQEAKWSNNKIIPAFSKYLENASVSSSGVALLAPSYFSVCQQQEDISDHALRSLTDFHGLVRSSCVIFRLCNDLATSAAELERGETTNSIISYMHENDGTSEEQAR

    EELRKLIDAEWKKMNRERVSDSTLLPKAFMEIAVNMARVSHCTYQYGDGLGRPDYATE

    NRIKLLLIDPFPINQLMYV

    > Lotus-corniculatus-var.-japonicus_ E-beta-ocimene synthase

  • 8/6/2019 KristinaMarieTurnerGossypolBLASTMatchSequenceHomology

    9/24

    MAQSFSMVLNSSFTSHPIFCKPQKLIIRGHNLLQGHRINSPIPCYASTSSTSVSQRKSANYQ

    PNIWNYDYLQSLKLGYADAHYEDMAKKLQEEVRRIIKDDKAEIWTTLELIDDVKRLGL

    GYHFEKEIREVLNKFLSLNTCVHRSLDKTALCFRLLREYGSDVSADIFERFLDQNGNFKTSLVNNVKGMLSLYEASFLSYEGEQILDKANAFTSFHLKSIHEEDINNILLEQVNHALELPL

    HRRIHRLEARWYTESYSRRKDANWVLLEAAKLDFNMVQSTLQKDLQEMSRWWKGMG

    LAPKLSFSRDRLMECFFWTVGMAFEPKYSDLRKGLTKVTSLITTIDDIYDVHGTLEELELFTAIVESWDIKAMQVLPEYMKISFLALYNTVNELAYDALREQGHDILPYLTKAWSDML

    KAFLQEAKWCREKHLPKFEHYLNNAWVSVSGVVILTHAYFLLNHNTTKEVLEALENYH

    ALLKRPSIIFRLCNDLGTSTAELQRGEVANSILSCMHENDIGEESAHQHIHSLLNETWKKMNRDRFIHSPFPEPFVEIATNLARIAQCTYQTGDGHGAPDSIAKNRVKSLIIEPIVLNGDIY

    > Cinnamomum-tenuipilum_ geraniol synthase [Cinnamomum tenuipilum]

    MALQMIAPFLSSFLPNPRHSLAAHGLTHQKCVSKHISCSTTTPTYSTTVPRRSGNYKPSI

    WDYDFVQSLGSGYKVEAHGTRVKKLKEVVKHLLKETDSSLAQIELIDKLRRLGLRWLFKNEIKQVLYTISSDNTSIEMRKDLHAVSTRFRLLRQHGYKVSTDVFNDFKDEKGCFKPSL

    SMDIKGMLSLYEASHLAFQGETVLDEARAFVSTHLMDIKENIDPILHKKVEHALDMPLH

    WRLEKLEARWYMDIYMREEGMNSSLLELAMLHFNIVQTTFQTNLKSLSRWWKDLGLG

    EQLSFTRDRLVECFFWAAAMTPEPQFGRCQEVVAKVAQLIIIIDDIYDVYGTVDELELFTNAIDRWDLEAMEQLPEYMKTCFLALYNSINEIGYDILKEEGRNVIPYLRNTWTELCKAF

    LVEAKWYSSGYTPTLEEYLQTSWISIGSLPMQTYVFALLGKNLAPESSDFAEKISDILRLGGMMIRLPDDLGTSTDELKRGDVPKSIQCYMHEAGVTEDVARDHIMGLFQETWKKLNE

    YLVESSLPHAFIDHAMNLGRVSYCTYKHGDGFSDGFGDPGSQEKKMFMSLFAEPLQVD

    EAKGISFYVDGGSA

    > Citrus-limon_ 1 (+)-limonene synthase 2 [Citrus limon]MSSCINPSTLVTSANGFKCLPLATNKAAIRIMAKNKPVQCLVSAKYDNLIVDRRSANYQ

    PSIWDHDFLQSLNSNYTDETYRRRAEELKGKVKIAIKDVTEPLDQLELIDNLQRLGLAYR

    FETEIRNILHNIYNNNKDYVWRKENLYATSLEFRLLRQHGYPVSQEVFNGFKDDQGGFIFDDFKGILSLHEASYYSLEGESIMEEAWQFTSKHLKEVMISKSMEEDVFVAEQAKRALEL

    PLHWKVPMLEARWFIHVYEKREDKNHLLLELAKMEFNTLQAIYQEELKEISGWWKDT

    GLGEKLSFARNRLVASFLWSMGIAFEPQFAYCRRVLTISIALITVIDDIYDVYGTLDELEIFTDAVARWDINYALKHLPGYMKMCFLALYNFVNEFAYYVLKQQDFDMLLSIKNAWLG

    LIQAYLVEAKWYHSKYTPKLEEYLENGLVSITGPLIIAISYLSGTNPIIKKELEFLESNPDIV

    HWSSKIFRLQDDLGTSSDEIQRGDVPKSIQCYMHETGASEEVAREHIKDMMRQMWKKVNAYTADKDSPLTRTTTEFLLNLVRMSHFMYLHGDGHGVQNQETIDVGFTLLFQPIPLED

    KDMAFTASPGTKG

    > Citrus-unshiu_ beta-pinene synthase [Citrus unshiu]

    MALNLLSSLPAAGNFTILSLPLSSKVNGFVPPITRVQYPMAASTTXIKPVDQTIIRRSADYGPTIWSFDYIQSLDSKYKGESYARQLEKLKEQVSAMLQQDNKVVDLDPLHQLELIDNLH

    RLGVSYHFEDEIKRTLDRIHNKNTNENLYATALKFRILRQYGYNTPVKETFSRFMDEKG

    SFKSSSHGDDCKGMLALYEAAYLLVEEESSIFRDAKSFTTAYLKEWVIKHDNNKHDDEHLCTLVNHALELPLHWRMPRLEARWFIDVYENGPDMNPILLELAKVDFNIVQAVHQEN

    LKYASRWWKKTGLGENLNFVRDRIVENFMWTVGEKFEPQFGYFRRMSTMVNALITAV

    DDVYDVYGTLDELEIFTDAVERWDATVVEKLPHYMKLCFHALRNSINEMTFDALRDQGVDIVISYLTKAWADICKAYLVEAKWYNSGYIPPLQEYMENAWISIGATVILVHANTFTA

    NPITKEGLEFVKDYPNIIRWSSVILRFADDLGTSSDELKRGDVHKSIQCYMHEAGVSEGE

    AREHINDLIAQTWMKINRDRFGNPHFVSDVFVGIAMNLARMSQCMYQFGDGHGCGAQ

    EITKARVLSLFFDPIA

  • 8/6/2019 KristinaMarieTurnerGossypolBLASTMatchSequenceHomology

    10/24

    > Populus-tremuloides_ isoprene synthase [Populus tremuloides]

    MATELLCLHRPISLTHKLFRNPLPKVIQATPLTLKLRCSVSTENVSFSETETETRRSANYE

    PNSWDYDYLLSSDTDESIEVHKDKAKKLEAEVRREINNEKAEFLTLLELIDNVQRLGLGYRFESDIRRALDRFVSSGGFDGVTKTSLHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNF

    LENLKEDIKAILSLYEASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVSHALELP

    LHRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRETSRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFSFVTIIDDIYDVYGTLDELELF

    TDAVERWDVNAINDLPDYMKLCFLALYNTINEIAYDNLKDKGENILPYLTKAWADLCN

    AFLQEAKWLYNKSTPTFDDYFGNAWKSSSGPLQLIFAYFAVVQNIKKEEIENLQKYHDIISRPSHIFRLCNDLASASAEIARGETANSVSCYMRTKGISEELATESVMNLIDETWKKMNK

    EKLGGSLFAKPFVETAINLARQSHCTYHNGDAHTSPDELTRKRVLSVITEPILPFER

    > Populus-alba_ isoprene synthase [Populus alba]

    MATELLCLHRPISLTHKLFRNPLPKVIQATPLTLKLRCSVSTENVSFTETETEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINNEKAEFLTLLELIDNVQRLGLG

    YRFESDIRGALDRFVSSGGFDAVTKTSLHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNF

    LENLKEDIKAILSLYEASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALEL

    PLHRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRETSRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFSFVTIIDDIYDVYGTLDELEL

    FTDAVERWDVNAINDLPDYMKLCFLALYNTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTFDDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYH

    DTISRPSHIFRLCNDLASASAEIARGETANSVSCYMRTKGISEELATESVMNLIDETWKK

    MNKEKLGGSLFAKPFVETAINLARQSHCTYHNGDAHTSPDELTRKRVLSVITEPILPFER

    > Pyrus-communis_ farnesene synthase [Pyrus communis]MEFRVHLHADHEQKILQNQMKPEPEASYLINQRRSANYKPNIWKNDFLDQSLISKYDED

    QYRKLSEKLIEEVKIYISAETKDLVAKFELIDSVRKLGLANHFEKEIKEALDSIAAIESDNL

    GTRDDLYGTALHFKILRQHGYKVSQDIFGRFMDEKGTLENHHFAHLKGMLELFEASNLGFEGEDILDEAKASLTLALRDSGHICYPDSNLSRDVIHSLELPSHRRVQWFDVKWQINAY

    EKDICRVNATLLELAKLNFNMVQAQLQKDLREASKWWANLGIADNLKFARDRLVECF

    ACAVGVAFEPEYSSFRICLTKVINLVLIIDDVYDIYGSEEELKHFTNAVDRWDSRETEQLPECMKMCFQVLYNTTCEIAHEIEKENGWNQVLPQLTKVWADFCKALLVEAEWYNKSHI

    PTLEEYLRNGCNSSSVSILLVHSFFSITHEGTKEMADFLHKNEDLLYNLSLIVRLNNDLGT

    SAAEQERGDSPSSIVCYMREVNASEEIARKNIKGMIDNAWKKVNGKCFTTNQVPFLSSFMNNATNMARVAHSLYKDGDGFGDQEKGPRTHILSLLFQPLVN

    > Mentha-aquatica_ linalool synthase [Mentha aquatica]

    MCTIISVNHHHVAILSKPKVKLFHTKNKRSASINLPWSLSPSSSAASRPISCSISSKLYTISS

    AQEETRRSGNYHPSVWDFDFIQSLDTDHYKEEKQLEREEELIMEVKKLLGAKMEATKQLELIDDLQNLGLSYFFRDEIKNILNSIYKIFQNNNSTKVGDLHFTSLGFRLLRQHGFNVSQ

    GVFDCFKNEHGSDFEKTLIGEDTKGVLQLYEASFLLREGEDTLEVARKFSTEFLEEKLKA

    GIDGDNLSSSIGHSLEIPLHWRIQRLEERWFLDAYSRRKDMNPIIFELAKLDFNIIQATQQEELKDLSRWWNDSSLPQKLPFVRDRLVESYYWALGLFEAHKFGYERKTAAKIITLITALD

    DVYDIYGTLDELQLFTHVIRRWDTESATQLPYYLQLFYFVLYNFVSEVAYHILKEEGFISI

    PFLHRAWVDLVEGYLQEAKWYYTKYTPTMEEYLNYASITIGAPAVISQIYFMLAKSKEKPVIESFYEYDEIIRLSGMLVRLPDDLGTLPFEMKRGDVAKSIQIYMKEQNATREEAEEHV

    RFMIREAWKEMNTTMAANSDLRGDVVMAAANLGRDAQFMYLDGDGNHSQLQHRIAN

    LLFKPYV

    > Mentha-longifolia_ 1 limonene synthase [Mentha longifolia]

  • 8/6/2019 KristinaMarieTurnerGossypolBLASTMatchSequenceHomology

    11/24

    MALKVFSVATQMAIPSKLTRCLQPSHLKSSPKLLSSTNSSSRSRLRVYCSSSQLTTERRSG

    NYNPSRWDVEFIQSLHSDYEEDKHAIRASELVTLVKMELEKETDHIRQLELIDDLQRMG

    LSDHFQNEFKEILSSIYLDHHYYKNPFPKEERDLYSTSLAFRLLREHGFQVAQEVFDSFKNEEGEFKESLSDDTRGLLQLYEASFLLTEGETTLESAREFATKFLEERVNEGGVDGDLLT

    RIAYSLDIPLHWRIKRPNAPAWIEWYRKRPDMNPVVLELAILDLNIVQAQFQEELKESFR

    WWRNTGFVEKLPFARDRLVECYFWNTGIIEPRQHASARIMMGKVNALITVIDDIYDVYGTLEELEQFTDLIRRWDINSIDQLPDYMQLCFLALNNFVDDTSYDVMKEKGVNVIPYLRQ

    SWVDLADKYMVEARWFYGGHKPSLEEYLENSWQSISGPCMLTHIFFRVTDSFTKETVD

    SLYKYHDLVRWSSFVLRLADDLGTSVEEVSRGDVPKSLQCYMSDYNASEAEARKHVKWLIAEVWKKMNAERVSKDSPFGKDFIGCAADLGRMAQLMYHNGDGHGTQHPIIHQQM

    TRTLFEPFA

    > Malus-x-domestica_ alpha-farnesene synthase [Malus x domestica]

    MEFRVHLQADNEQKIFQNQMKPEPEASYLINQRRSANYKPNIWKNDFLDQSLISKYDGDEYRKLSEKLIEEVKIYISAETMDLVAKLELIDSVRKLGLANLFEKKIKEALDSIAAIESDNL

    GTRDDLYGAALHFKILRQHGYKVSQDIFGRFMDEKGTLENHHFAHLKGMLELFEASNL

    GFEGEDILDEAKASLTLALRDSGHICYPDSNLSRDVVHSLELPSHRRVQWFDVKWQINA

    YEKDICRVNATLLELAKLNFNVVQAQLQKNLREASRWWANLGFADNLKFARDGLVECFSCAVGVAFEPEHSSFRICLTKVINLVLIIDDVYDIYGSEEELKHFTNAVDRWDSRETEQL

    PECMKMCFQVLYNTTCEIAREIEEENGWNQVLPQLTKVWADFCKALLVEAEWYNKSHIPTLEEYLRNGCISSSVSVLLVHSFFSITHEGTKEMADFLHKNEDLLYNISLIVRLNNDLGT

    SAAEQERGDSPSSIVCYMREVNASEETARKNIKGMIDNAWKKVNGKCFTTNQVPFLSSF

    MNNATNMARVAHSLYKDGDGFGDQEKGPRTHILSLLFQPLVN

    > Perilla-citiodora_ linalool synthase [Perilla citriodora]MSSIRIYVAIMKKPSVKHVDNVDKKASKLSWRVSSSATAGLRASSSLQLDVKKPADEIL

    TARRSGNYQPSLWDFNYLQSLNTTHYKEERHLKREAELIEQVKMLLDEEMEAVQKLDL

    VDDLKNLGLSYFFEDQIKQILTFIYNEHECFRSNVEAKERDLYFTALGFRLLRQHGFQVSQEVFDCFKNEEGSDFKASLGDDTKGLLQLYEASFLLREGEDTLELARQYATKFLQKKV

    DHELIDDDSNLLSWIRHSLEIPLHWRIQRLEARWFLDAYATRHDVNPIILELAKLDFNIIR

    ATQQEELKDLSRWWNSTCLAEKLPFVRDRLVESYFWAIALFEPHQYGYHRKIAAKIITLITSLDDVYDIYGTLDELQLFTDAIQRWDTESISRLPYYMQLFYMVLYNFVSELAYDGLKE

    KGFIIPYLQRSWADLVVAYLKEAKWFYNGYTPSMEEYLNNAYISIGATPVISQVFFTLAT

    SIDKPVIESLYEYHRILRLSGMLVRLPDDLGTSSFEMKRGDVPKTIELYMKERNATEIEAQEHVRFLIREAWKEMNTATAAADCPFTDDLVAAAANLGRAAQFMYLDGDGNHSQLHQ

    RIASLLFEQYA

    > Agastache-rugosa_ d-limonene synthase [Agastache rugosa]

    MALKMTSVVMQMAIPTKLANFVHNSDNNKSLKLVRNVSTTCTSAATPRLRLPVCCSSSSSSSSQLPTIERRSGNYSPSRWDVDFIQSLNSDYQEERHTRRASELITQVKMLMEKETTDP

    IRQLELIDDLQRLGLSDHFQNEFKEILNTIYLDNKYYNINIMREESRDLYSTALAFRLLRE

    HGFQVAQEVFECFKNEEGDFKASLIDDTRGLLQLYEASFLFKEGENTLEIAREFTTKILQEKLKGDEIDDNLLSSIRYSLEIPNYWSVVRPNVSVWIDEYRKRSDMNPVVLELAILDANIV

    QAQLQLELKESLRWWRNTCFVEKLPFARDRLIESYFWSTGMVEPRQHANARIIMAKVIA

    LITVMDDIYDVYGTLEELEQFTEAFRRWDVSSIDQLPTYMQLCFLAINNFVDDTAYNVLKESGVNVMTYLRKSWVDQAENYLMESKWYYSGHKPSLEEYLENSWISVSGPCVLTHE

    FFGVTDSLAKDTLDSLYEYHDIVRWSSYLLRLADDLGTSVEEVSRGDVPKSIQCYMHDN

    DASEEEARQHIKGLIREMWKKMNVERVSEDSPFCRDFIRCCEDLGRMAQFMYHYGDGH

    GTQHPKIHQQIAACLFQPFA

  • 8/6/2019 KristinaMarieTurnerGossypolBLASTMatchSequenceHomology

    12/24

    > Abies-grandis_ pinene synthase [Abies grandis]

    TAPLASKSCLHKSLISSTHELKALSRTIPALGMSRRGKSITPSISMSSTTVVTDDGVRRRM

    GDFHSNLWDDDVIQSLPTAYEEKSYLERAEKLIGEVENMFNSMSLEDGELMSPLNDLIQRLWIVDSLGRLGIHRHFKDEIKSALDYVYSYWGENGIGCGRESAVTDLNSTALGFRTLR

    LHGYPVSSDVFKAFKGQNGQFSCSENIQTDEEIRGVLNLFRASLIAFPGEKIMDEAEIFST

    KYLKEALQKIPVSSLSREIGDVLEYGWHTYLPRLEARNYIHVFGQDTENTKSYVKSKKLLELAKLEFNIFQSLQKRELESLVRWWKESGFPEMTFCRHRHVEYYTLASCIAFEPQHSGF

    RLGFAKTCHLITVLDDMYDTFGTVDELELFTATMKRWDPSSIDCLPEYMKGVYIAVYD

    TVNEMAREAEEAQGRDTLTYAREAWEAYIDSYMQEARWIATGYLPSFDEYYENGKVSCGHRISALQPILTMDIPFPDHILKEVDFPSKLNDLACAILRLRGDTRCYKADRARGEEASS

    ISCYMKDNPGVSEEDALDHINAMISDVIKGLNWELLKPDINVPISAKKHAFDIARAFHYG

    YKYRDGYSVANVETKSLVTRTLLESVPL

    > Salvia-stenophylla_ 1 3-carene synthase [Salvia stenophylla]MAFPRNPTKLLHKPHNKSSKLISNSRISSYGHLPLRCSSQQLPTDEFQVERRSGNYSPSK

    WDVDYIQSLHSDYKEERHTRRASELIMEVKKLLEKEPNPTRQLELIDDLQKLGLSDHFN

    NEFKEILNSVYLDNKYYRNGAMKEVERDLYSTALAFRLLRQHGFQVAQDVLECFKNTK

    GEFEPSLSDDTRGLLQLYEASFLLTEGENTLELARDFTTKILEEKLRNDEIDDINLVTWIRHSLEIPIHWRIDRVNTSVWIDVYKRRPDMNPIVLELAVLDSNIVQAQYQEELKLDLQWW

    RNTCLAEKLPFARDRLVESYFWGVGVVQPRQHGIARMAVDRSIALITVIDDVYDVYGTLEELEQFTEAIRRWDISSIDQLPSYMQLCFLALDNFINDIAYDVLKEQGFNIIPYLRKSWTD

    MIEGFLLEAKWYHNGHKPKLEEYLENGWRSIGSTVVLTHAFFGVTHSLTKENIDQFFGY

    HEIVRLSSMLLRLADDLGTSTDEVSRGDVPKAIQCYMNDNIGASEAEAREHVKWCIWET

    WKKMNKVRVARDTPFSQDFIVCAMGMGRMGQYMYHYGDGHGIQHSIIHQQMSTCLFHPSSSN

    > Schizonepeta-tenuifolia_ (+)-4R-limonene synthase [Schizonepeta tenuifolia]

    MALKMTSAVMQMAIPTKLANFVNNSDTHKQSLKLLRNVSTISTSAAAATPRHRLPVCCSASSSSSSQLPTIERRSGNYKPSRWDVDFMQSLNSDYQEERHRTKASELITQVKNLLEKE

    TSDDPIRQLELIDDLQRLGLSDHFEHEFKEVLNSIYLDNKYYNINIMKETTSSRDLYSTAL

    AFRLLREHGFQVAQEVFDCFKNEEGEFKASLSDDPRGLLQLYEASFLFKEGENTLEIAREFATKLLQEKVNSSDEIDDNLLSSIRYSLEIPTYWSVIRPNVSVWIDAYRKRPDMNPVVLE

    LAILDANIMQAQLQQELKEALGWWRNTWFVEKLPFARDRLVESYFWSTGMVPRRQHK

    TARQLMAKVIALITVMDDIYDVYGTLEELELFTDAFRRWDVSSIDHLPTYMQLCFLSINNFVVDTAYNILKETGVNVTTYLEKSWVDQAENYLMESKWFYSGHKPSLDEYLENSWISV

    SGPCVLTHEFFGVTDSLAKDTLDSLYEYHDIVRWSSYLLRLADDLGTSVEEVSRGDVPK

    SIQCYMNDNNASEEEAREHVKGLIRVMWKKMNAERVSEDSPFCKDFIRCCEDLGRMAQ

    FMYHYGDGHGTQHAKIHQQITDCLFQPFA> Melaleuca-alternifolia_ putative monoterpene synthase [Melaleuca > alternifolia]

    MALRLLSTPHLPQLCSRRVSGRVHCSASTQVSDAQGGRRSANYQPSVWTYNYLQSLVA

    DDIRRSRREVEQEREKAQILEEDVRGALNDGNAEPMAIFALVDDIQRLGLGRYFEEDISKALRRCLSQYAVTGSLQKSLHGTALSFRVLRQHGFEVSQDVFKIFMDESGSFMKTLGGDV

    QGMLSLYEASHLAFEEEDILHKAKTFAIKHLENLNHDIDQDLQDHVNHELELPLHRRMP

    LLEARRFIEAYSRRSNVNPRILELAVMKFNSSQLTLQRDLQDMLGWWNNVGLAKRLSFARDRLMECFFWAVGIAREPALSNCRKGVTKAFSLILVLDDVYDVFGTLDELELFTDAVR

    RWHEDAVENLPGYMKLCFLALYNSVNDMAYETLKETGENVTPYLTKVWYDLCKAFL

    QEAKWSYNKITPGVEEYLNNGWVSSSGQVMLTHAYFLSSPSLRKEELESLEHYHDLLRL

    PSLIFRLTNDLATSSAELGRGETTNSILCYMREKGFSESEARKQVIEQIDTAWRQMNKYM

  • 8/6/2019 KristinaMarieTurnerGossypolBLASTMatchSequenceHomology

    13/24

    VDHSTFNRSFMQMTYNLARMAHCVYQDGDAIGAPDDQSWNRVHSLIIKPVSLAPC

    > Abies-grandis_ E-alpha-bisabolene synthase [Abies grandis]

    AGVSAVSKVSSLVCDLSSTSGLIRRTANPHPNVWGYDLVHSLKSPYIDSSYRERAEVLVSEIKVMLNPAITGDGESMITPSAYDTAWVARVPAIDGSARPQFPQTVDWILKNQLKDGSW

    GIQSHFLLSDRLLATLSCVLVLLKWNVGDLQVEQGIEFIKSNLELVKDETDQDSLVTDFE

    IIFPSLLREAQSLRLGLPYDLPYIHLLQTKRQERLAKLSREEIYAVPSPLLYSLEGIQDIVEWERIMEVQSQDGSFLSSPASTACVFMHTGDAKCLEFLNSVMIKFGNFVPCLYPVDLLER

    LLIVDNIVRLGIYRHFEKEIKEALDYVYRHWNERGIGWGRLNPIADLETTALGFRLLRLH

    RYNVSPAIFDNFKDANGKFICSTGQFNKDVASMLNLYRASQLAFPGENILDEAKSFATKYLREALEKSETSSAWNNKQNLSQEIKYALKTSWHASVPRVEAKRYCQVYRPDYARIAK

    CVYKLPYVNNEKFLELGKLDFNIIQSIHQEEMKNVTSWFRDSGLPLFTFARERPLEFYFL

    VAAGTYEPQYAKCRFLFTKVACLQTVLDDMYDTYGTLDELKLFTEAVRRWDVSFTEN

    LPDYMKLCYQIYYDIVHEVAWEAEKEQGRELVSFFRKGWEDYLLGYYEEAEWLAAEYVPSLDEYIKNGITSIGQRILLLSGVLIMDGQLLSQEALEKVDYPGRRVLTELNSLISRLAD

    DTKTYKAEKARGELASSIECYMKDHPECTEEEALDHIYSILEPAVKELTREFLKPDDVPF

    ACKKMLFEETGVTMVIFKDGDGFGVSKLEVKDHIKECLIEPLPL

    > Picea-abies_ (-)-limonene synthase [Picea abies]MSPVSVIPLAYKLCLPRSLMSSSREVKPLHITIPNLGMCRRGKSMAPASTSMILTAAVSD

    DDRVQRRRGNYHSNLWDDDFIQSLSTPYGEPSYRERAERLKGEIKKMFRSMSKDDGELITPLNDLIQRLWMVDSVQRLGIDRHFKNEIKSALDYVYSYWNEKGIGCGRDSVVADLNS

    TALGFRTLRLHGYNVSSEVLKVFEDQNGQFACSPSKTEGEIRSALNLYRASLIAFPGEKV

    MDDAEIFSSRYLKEAVQEIPDCSLSQEIAYALEYGWHTNMPRLEARNYMDVFGHPSSPW

    LKKNKTQYMDGEKLLELAKLEFNIFHSLQQEELQYISRWWKDSGLPKLAFSRHRHVEYYTLGSCIATDPKHRAFRLGFVKTCHLNTVLDDIYDTFGTMDEIELFTEAVRRWDPSETES

    LPDYMKGVYMVLYEALTEMAQEAQKTQGRDTLNYARKAWEIYLDSYIQEAKWIASGY

    LPTFQEYFENGKISSAYRAAALTPILTLDVPLPEYILKGIDFPSRFNDLASSFLRLRGDTRCYKADRARGEEASCISCYMKDNPGSTEEDALNHINSMINEIIKELNWELLRPDSNIPMPAR

    KHAFDITRALHHLYKYRDGFSVATKETKSLVSRMVLEPVPL

    > Pseudotsuga-menziesii_ (E)-gamma-bisabolene synthaseMAASTLPSGLSTNDLIRRTANPHPNVWGYDLLCSLKSPYSRDSSYKERADTLINEIKAML

    GAAFGDGKEMITPSAYDTAWVARIPSIDGSSGSARPQFPQTVDWILKNQLKDGSWGTES

    HFLLSEPLLATISCVLALFKWQVGDLQVERGIEFLKSSLEKIKNESDQDSLVTDFEIIFPSMLREAQSLHLGLPYDLPYIQLLQTKRQERLANLSREKIHGGILQLSSLEGIEDMVEWERLM

    DLQSLDGSFLSSPASTAFVFIHTGDLKCLAFLNSVLAKFGAFVPCLYHVDLLERLLIVDNI

    ERLGIDRHFEKEINEALDYVYRYWSNERGIGWGRMNATADLETTALGFRLLRLHRYHV

    SPVVFKKFKDADGEFLSSIGQFNKDVASMLNLYRACELAFPGENILDEAKGFTAKYLREALEKTETFSSWNIKRNLSQEIKYALKTSWHASIPRVEAKRYCQVYRPDYARLDKSVYKL

    HHVNNEKILELAKLDFNIIQSILQEEMKNVTSWFRDSGLPLFSFARQRPLEFYFLITAGTY

    EPRYAKCRLLFTKVACVETVLDDMYDTYGTLDELKLFTQAVRRWDPSLTENLPDYMKRCYKIFYDIVHEAAWEAEKEQGRELVSFLRKAWEDFVLSYHEEAEWLSAEYVPGFDEYI

    KNGITSIGQRVLLLSGLLVMDGQLLSQKALEKIDYPERSRVLMEQICLISRLADDTQSYK

    AEKARGELASGIECYMKDHPECTEEEALNHIYGIMEVTAKELTKEYLKVDDDDVPFACKKMLFEETRVTMVIFKDGDRLSNSKLEMKDHFKECLIEPLPL

    > Pinus-taeda_ (-)-alpha-pinene synthase [Pinus taeda]

    MSPVSVISLPSDLCLPTSFIDRSGRELIPLHITIPNVAMRRQGKLMTRASMSMNLRTAVSD

    DAVIRRRGDFHSNLWDDDLIQSLSSPYGEPSYRERAERLIGEVKNSFNSMSNEDGESITPL

  • 8/6/2019 KristinaMarieTurnerGossypolBLASTMatchSequenceHomology

    14/24

    DDLIQRLWMVDSVERLGIDRHFKKEIKSALDHVYRYWSEKGIGCGRESVVTDLNSTAL

    GLRTLRLHGYDVSADVLNHFKNQSGQFACTLKQTEDQIRTVLNLYRASLIAFPGEKVM

    DEAESFSAKYLKEALQKIPVSSFSREIGDVLEYGWHTYLPRLEARNYIDVFGQDTENSKSYMKTEKLLELAKLEFNIFHALQKRELEYLVRWWKGSGSPQMTFCRHRHVEYYTLASCI

    AFEPQHSGFRLGFAKACHIITVLDDMYDTFGTLDELELFTSAIKRWDPSATECLPEYMKG

    VYMIVYNTVNEMSQEADKAQGRDTLNYCRQAWEEYIDAYMQEAKWIASGEVPTFEEYYENGKVSSGHRVSALQPILTTDIPFPEHVLKEVDIPSQLNDLASAILRLRGDTRCYQADR

    ARGEEASCISCYMKDNPGTTEEDALNHLNAMISDVIKGLNWELLKPNSSVPISAKKHAF

    DISRAFHCGYKYRDGYSVANIETKSLVKRTVIDPVTL> Chamaecyparis-obtusa_ limonene/borneol synthase [Chamaecyparis obtusa]

    MALISLSSSAFTFCLKSKPTHLSKPSPKSFPTLARKCMRNTMAMATTSVESVTRRTGNHH

    GNLWDDDFIQSLPKLPYDAPEYRERADRLVGEVKNMFNAVRAADSSSQNILRLLEMVD

    KVERLGIGRHFETEIAEALDYVYRFWNDISSKDLNTAALGLRILRLHRYPVSSDVLEQFKEKDGHFLCCTTQLEEEIKSILNLFRASLIAFPNEKIMDEAKAFSTMYLKQVFQKSHILGTL

    LKEITFNLEYGWRTNLPRLEARNYMDIYGENSSWLMDMDNKNILYLAKLDFNILQSLY

    RPELQMISRWWKDSSLYKLDFSRHRHIEYLFQGCAITGEPKHSGFRIDIAKYSTLATIIDDI

    YDTYGSIEELKHFTEVFKRWDSSPPDYLPEYMKIAYSALYDGINKSAQEAVQIQGRDTLH

    NARNAWDDYLDAVMQEAKWNSIGHMPNLKEFLENGRVSSGTRVITLQALLRLEALQESELQKIDHPSKFNYLFGLTLRLRGDTRTFKAEANRGEVTSSIACYLKEHPESTEKDALKY

    LQFMLDENLKELNLEYLKNDGVPICIKDFAYDMSRCFEVFYKERDGFSISTKDMKNHVE

    RILIEPVEM

    > Antirrhinum-majus_ (E)-b-ocimene synthase [Antirrhinum majus]MAFCISYLGAVLPFSLSPRTKFAIFHNTSKHAAYKTCRWNIPRDVGSTPPPSKLHQALCL

    NAHSTSCMAELPMDYEGKIQGTRHLLHLKDENDPIESLIFVDATQRLGVNHHFQKEIEEI

    LRKSYATMKSPSICKYHTLHDVSLFFCLMRQHGRYVSADVFNNFKGESGRFKEELKRDTRGLVELYEAAQLSFEGERILDEAENFSRQILHGNLASMEDNLRRSVGNKLRYPFHKSIAR

    FTGINYDDDLGGMYEWGKTLRELALMDLQVERSVYQEELLQVSKWWNELGLYKKLTL

    ARNRPFEFYMWSMVILTDYINLSEQRVELTKSVAFIYLIDDIFDVYGTLDELIIFTEAVNKWDYSATDTLPDNMKMCYMTLLDTINGTSQKIYEKYGHNPIDSLKTTWKSLCSAFLVEA

    KWSASGSLPSANEYLENEKVSSGVYVVLIHLFFLMGLGGTNRGSIELNDTRELMSSIAIIV

    RIWNDLGCAKNEHQNGKDGSYLDCYKKEHINLTAAQVHEHALELVAIEWKRLNKESFNLNHDSVSSFKQAALNFARMVPLMYSYDNNRRGPVLEEYVKFMLSD

    > Ginkgo-biloba_ 1 levopimaradiene synthase [Ginkgo biloba]

    MAGVLFANLPCSLQLSPKVPFRQSTNILIPFHKRSSFGFNAQHCVRSHLRLRWNCVGIHA

    SAAETRPDQLPQEERFVSRLNADYHPAVWKDDFIDSLTSPNSHATSKSSVDETINKRIQTLVKEIQCMFQSMGDGETNPSAYDTAWVARIPSIDGSGAPQFPQTLQWILNNQLPDGSWG

    EECIFLAYDRVLNTLACLLTLKIWNKGDIQVQKGVEFVRKHMEEMKDEADNHRPSGFE

    VVFPAMLDEAKSLGLDLPYHLPFISQIHQKRQKKLQKIPLNVLHNHQTALLYSLEGLQDVVDWQEITNLQSRDGSFLSSPASTACVFMHTQNKRCLHFLNFVLSKFGDYVPCHYPLDL

    FERLWAVDTVERLGIDRYFKKEIKESLDYVYRYWDAERGVGWARCNPIPDVDDTAMG

    LRILRLHGYNVSSDVLENFRDEKGDFFCFAGQTQIGVTDNLNLYRCSQVCFPGEKIMEEAKTFTTNHLQNALAKNNAFDKWAVKKDLPGEVEYAIKYPWHRSMPRLEARSYIEQFGS

    NDVWLGKTVYKMLYVSNEKYLELAKLDFNMVQALHQKETQHIVSWWRESGFNDLTF

    TRQRPVEMYFSVAVSMFEPEFAACRIAYAKTSCLAVILDDLYDTHGSLDDLKLFSEAVR

    RWDISVLDSVRDNQLKVCFLGLYNTVNGFGKDGLKEQGRDVLGYLRKVWEGLLASYT

  • 8/6/2019 KristinaMarieTurnerGossypolBLASTMatchSequenceHomology

    15/24

    KEAEWSAAKYVPTFNEYVENAKVSIALATVVLNSIFFTGELLPDYILQQVDLRSKFLHLV

    SLTGRLINDTKTYQAERNRGELVSSVQCYMRENPECTEEEALSHVYGIIDNALKELNWE

    LANPASNAPLCVRRLLFNTARVMQLFYMYRDGFGISDKEMKDHVSRTLFDPVA> Taxus-brevifolia_ taxadiene synthase

    MAQLSFNAALKMNALGNKAIHDPTNCRAKSERQMMWVCSRSGRTRVKMSRGSGGPG

    PVVMMSSSTGTSKVVSETSSTIVDDIPRLSANYHGDLWHHNVIQTLETPFRESSTYQERADELVVKIKDMFNALGDGDISPSAYDTAWVARLATISSDGSEKPRFPQALNWVFNNQLQ

    DGSWGIESHFSLCDRLLNTTNSVIALSVWKTGHSQVQQGAEFIAENLRLLNEEDELSPDF

    QIIFPALLQKAKALGINLPYDLPFIKYLSTTREARLTDVSAAADNIPANMLNALEGLEEVIDWNKIMRFQSKDGSFLSSPASTACVLMNTGDEKCFTFLNNLLDKFGGCVPCMYSIDLLE

    RLSLVDNIEHLGIGRHFKQEIKGALDYVYRHWSERGIGWGRDSLVPDLNTTALGLRTLR

    MHGYNVSSDVLNNFKDENGRFFSSAGQTHVELRSVVNLFRASDLAFPDERAMDDARKF

    AEPYLREALATKISTNTKLFKEIEYVVEYPWHMSIPRLEARSYIDSYDDNYVWQRKTLYRMPSLSNSKCLELAKLDFNIVQSLHQEELKLLTRWWKESGMADINFTRHRVAEVYFSSA

    TFEPEYSATRIAFTKIGCLQVLFDDMADIFATLDELKSFTEGVKRWDTSLLHEIPECMQT

    CFKVWFKLMEEVNNDVVKVQGRDMLAHIRKPWELYFNCYVQEREWLEAGYIPTFEEY

    LKTYAISVGLGPCTLQPILLMGELVKDDVVEKVHYPSNMFELVSLSWRLTNDTKTYQAEKARGQQASGIACYMKDNPGATEEDAIKHICRVVDRALKEASFEYFKPSNDIPMGCKSFIF

    NLRLCVQIFYKFIDGYGIANEEIKDYIRKVYIDPIQV> Taxus-baccata_ taxadiene synthase [Taxus baccata]

    MAQLSFNAALKMNALGNKAIHDPTNCRAKSERQMMWVCSRSGRTRVKMSRGSGGPG

    PVVMMSSSTGTSKVVSETSSTIVDDIPRLSANYHGDLWHHNVIQTLETPFRESSTYQERA

    DELVVKIKDMFNALGDGDISPSAYDTAWVARVATVSSDGSEKPRFPQALNWVLNNQLQDGSWGIESHFSLCDRLLNTVNSVIALSVWKTGHSQVEQGAEFIAENLRLLNEEDELSPDF

    EIIFPALLQKAKALGINLPYDLPFIKSLSTTREARLTDVSAAADNIPANMLNALEGLEEVI

    DWNKIMRFQSKDGSFLSSPASTACVLMNTGDEKCFTLLNNLLDKFGGCVPCMYSIDLLERLSLVDNIEHLGIGRHFKQEIKVALDYVYRHWSERGIGWGRDSLVPDLNTTALGLRTLR

    THGYDVSSDVLNNFKDENGRFFSSAGQTHVELRSVVNLFRASDLAFPDEGAMDDARKF

    AEPYLRDALATKISTNTKLYKEIEYVVEYPWHMSIPRLEARSYIDSYDDDYVWQRKTLYRMPSLSNSKCLELAKLDFNIVQSLHQEELKLLTRWWKESGMADINFTRHRVAEVYFSSA

    TFEPEYSATRIAFTKIGCLQVLFDDMADIFATLDELKSFTEGVKRWDTSLLHEIPECMQT

    CFKVWFKLMEEVNNDVVKVQGRDMLAHIRKPWELYFNCYVQEREWLEAGYIPTFEEYLKTYAISVGLGPCTLQPILLMGELVKDDVVEKVHYPSNMFELVSLSWRLTNDTKTYQAE

    KARGQQASGIACYMKDNPGATEEDAIKHICRVVDRALKEASFEYFKPSNDIPMGCKSFIF

    NLRLCVQIFYKFIDGYGIANEEIKDYIRKVYIDPIQV

    > Taxus-x-media_ taxadiene synthase [Taxus x media]MAQLSFNAALKMNALGNKAIHDPTNCRAKSEGQMMWVCSKSGRTRVKMSRGSGGPG

    PVVMMSSSTGTSKVVSETSSTIVDDIPRLSANYHGDLWHHNVIQTLETPFRESSTFQERA

    DELVVKIKDMFNALGDGDISPSAYDTAWVARVATVSSDGSEKPRFPQALNWVLNNQLQDGSWGIESHFSLCDRLLNTVNSVIALSVWKTGHSQVEQGTEFIAENLRLLNEEDELSPDF

    EIIFPALLQKAKALGINLPYDLPFIKSLSTTREARLTDVSAVADNIPANMLNALEGLEEVI

    DWNKIMRFQSKDGSFLSSPASTACVLMNTGDEKCFTLLNNLLDKFGGCVPCMYSIDLLERLSLVDNIEHLGIGRHFKQEIKVALDYVYRHWSERGIGWGRDSLVPDLNTTALGLRTLR

    THGYDVSSDVLNNFKDENGRFFSSAGQTHVELRSVVNLFRASDLAFPDEGAMDDARKF

    AEPYLRDALATKISTNTKLYKEIEYVVEYPWHMSIPRLEARSYIDSYDDDYVWQRKTLY

    RMPSLSNSKCLELAKLDFNIVQSLHQEELKLLTRWWKESGMADINFTRHRVAEVYFSSA

  • 8/6/2019 KristinaMarieTurnerGossypolBLASTMatchSequenceHomology

    16/24

    TFEPEYSATRIAFTKIGCLQVLFDDMADIFATLDELKSFTEGVKRWDTSLLHEIPECMQT

    CFKVWFKLMEEVNNDVVKVQGRDMLAHIRKPWELYFNCYVQEREWLEAGYIPTFEEY

    LKTYAISVGLGPCTLQPILLMGELVKDDVVEKVHYPSNMFELVSLSWRLTNDTKTYQAEKARGQQASGIACYMKDNPGATEEDAIKHICRVVDRALKEASFEYFKPSNDIPMGCKSFIF

    NLRLCVQIFYKFIDGYGIANEEIKDYIRKVYIDPIQV

    > Taxus-wallichiana-var.-chinensis_ taxadiene synthaseMAQLSFNAALKMNALGNKAIHDPTNCRAKSEGQMMWVCSKSGRTRVKMSRGSGGPG

    PVVMMSSSTGTSKVVSETSSTIVDDIPRLSANYHGDLWHHNVIQTLETPFRESSTYQERA

    DELVVKIKDMFNALGDGDISPSAYDTAWVARVATISSDGSEKPRFPQALNWVFNNQLQDGSWGIESHFSLCDRLLNTTNSVIALSVWKTGHSQVEQGTEFIAENLRLLNEEDELSPDF

    EIIFPALLQKAKALGINLPYDLPFIKYLSTTREARLTDVSAAADNIPANMLNALEGLEEV

    MDWKKIMRFQSKDGSFLSSPASTACVLMNTGDEKCFTFLNNLLVKFGGCVPCMYSIDL

    LERLSLVDNIEHLGIGRHFKQEIKVALDYVYRHWSERGIGWGRDSLVPDLNTTALGLRTLRTHGYDVSSDVLNNFKDENGRFFSSAGQTHVELRSVVILFRASDLAFPDEGAMDDAR

    KFAEPYLRDALATKISTNTKLFKEIEYVVEYPWHMSIPRSEARSYIDSYDDDYVWERKTL

    YRMPSLSNSKCLELAKLDFNIVQSLHQEELKLLTRWWKESGMADINFTRHRVAEVYFSS

    ATFEPEYSATRIAFTKIGCLQVLFDDMADIFATLDELKSFTEGVKRWDTSLLHEIPECMQTCFKVWFKLIEEVNNDVVKVQGRDMLAHIRKPWELYFNCYVQEREWLDAGYIPTFEEY

    LKTYAISVGLGPCTLQPILLMGELVKDDVVEKVHYPSNMFELVSLSWRLTNDTKTYQAEKARGQQASGIACYMKDNLGATEEDAIKHICRVVDRALKEASFEYFKPSNDIPMGCKSFIF

    NLRLCVQIFYKFIDGYGIANEEIKDYIRKVYIDPIQV

    > Stevia-rebaudiana_ 1 kaurene synthase [Stevia rebaudiana]

    MNLSLCIASPLLTKSSRPTALSAIHTASTSHGGQTNPTNLIIDTTKERIQKLFKNVEISVSSYDTAWVAMVPSPNSPKSPCFPECLNWLINNQLNDGSWGLVNHTHNHNHPLLKDSLSSTL

    ACIVALKRWNVGEDQINKGLSFIESNLASATDKSQPSPIGFDIIFPGLLEYAKNLDINLLSK

    QTDFSLMLHKRELEQKRCHSNEIDGYLAYISEGLGNLYDWNMVKKYQMKNGSVFNSPSATAAAFINHQNPGCLNYLNSLLDKFGNAVPTVYPLDLYIRLSMVDTIERLGISHHFRVEI

    KNVLDETYRCWVERDEQIFMDVVTCALAFRLLRIHGYKVSPDQLAEITNELAFKDEYA

    ALETYHASQILYQEDLSSGKQILKSADFLKGILSTDSNRLSKLIHKEVENALKFPINTGLERINTRRNIQLYNVDNTRILKTTYHSSNISNTYYLRLAVEDFYTCQSIYREELKGLERWVV

    QNKLDQLKFARQKTAYCYFSVAATLSSPELSDARISWAKNGILTTVVDDFFDIGGTIDEL

    TNLIQCVEKWNVDVDKDCCSEHVRILFLALKDAICWIGDEAFKWQARDVTSHVIQTWLELMNSMLREAIWTRDAYVPTLNEYMENAYVSFALGPIVKPAIYFVGPKLSEEIVESSEYH

    NLFKLMSTQGRLLNDIHSFKREFKEGKLNAVALHLSNGESGKVEEEVVEEMMMMIKNK

    RKELMKLIFEENGSIVPRACKDAFWNMCHVLNFFYANDDGFTGNTILDTVKDIIYNPLV

    LVNENEEQR> Scoparia-dulcis_ copalyl diphosphate [Scoparia dulcis]

    MALATFLRSPPSPGVFAAALHVPSSSTFGRTTTYVFPSYSWKTPVTSSNTSPCNAISRPRT

    EERIDLIRNGFPTINYWHEIVEDDTQLEITHRETAISSNKIWEMVKTIRGMLRSMEDGEITVSAYDTAWVALVEDIGGSGTPQFPSSLEWISNNQLPDGSWGDGATFSAHDRIINTLACVI

    ALRTWNMHSDKSDRGIAFIRENMYKLEDENEEHMPIGFEVALPSLIEIAKKIDIDIPDESPI

    FEKRLRKKRFKLKRIPRDIMHKVPTTLLHSLEGMPALDWEKLINLQSADGSFLFSPSSTAFALQQTKDHNCLHYPARHLQKFNGGVPNVYPVDLFEHLWAVDRLERLGLSRYFQPEIE

    ECIDYVHGHWTSKGICWARNSEVKDIDDTAMGFRLLKLHGYEVSADVFKHFENGGEFF

    CFVGQSTQAVTGMYNLFRASQVMFPGEDILSNAKSFLSKFLQEKRANNELLDKWIITKD

    LPGEVGYALDVPWYASLPRVETRLYLEQYGGQDDVWIGKTLYRMPYVNNNTYLELAK

  • 8/6/2019 KristinaMarieTurnerGossypolBLASTMatchSequenceHomology

    17/24

    LDYNNCQASHQQEWKSIQKWYSRCNFGEYGMSERSLLLAYYIAAASIFEPERALERLA

    WAKTAILMETIETILKDNSSQESGNVLSSMNPNLMAAACMQTEQVAGITKQERLTETLV

    RASKPLLIGTRCWHTAGTSISNCIMGRKSGLRTCEERDVHSGQGDAELLVRTLNLCGGGGRWVSEELLLSHPKYQHLLEVTNRVCHQLRLFQRRQACDVNGGCMTDVGGILSAQIES

    NMQELAKLVPTKSSSGDLDSDTKQNFLTVARSFYYAVYCNPGSINFHIAKVLFERVL

    > Croton-sublyratus_ copalyl diphosphate [Croton sublyratus]MSSQAFSLLSSLPSSSFSSTRPRLFLGVWYELQGQRISFNLRPRCTDLSITYTNEYVHGEM

    AVINPPEDDTEEQVPKVTNSICVKFNNKEKKSYIYDYEYNLILKLLIKVAISKEIMRSVERI

    KKMLKSMEDGEINISAYDTAWVRLVKDVNGSGEPQFPSALQWISNNQLPDGSWGDALVFNAHDRILSTLACVVTLKSWNLHPHKVAKGLKFFKENLSKLEEENEEHMSIGFEVVFP

    SLLELARKLDIDVPDDSHVLQQICECRNTKLKKIPKDIMHKMPTSLLHSLEGMPDLEWE

    KLLKLQFDNGSFLFSPSSTAYAFMQTQDDKCLIYLNRIVQRFNGGVPNVYPVDLFEHTW

    AADRLQRLGISRLFEQELKECMNYVARYWREDGMCWARNSNVRDVDDSSMGFRMLRLYGHNVSADVFKKFKKDDTWVCMPGQSTQAITGMYNLFRASQVLFPGEMILEEAREFC

    YDFLREKQSANAVVDKWIISKDLPGEVAYALDVPWFASLPTVEARFYIEQYGGDDDVW

    IGKVLYRMPFVNNNEYLELAKFDYNSCQALHRAEWDNFQKWYDECNLGDFGVSKREL

    LLAYYISAASIFEPEKSKERLAWAKTSILLQTIDAYFHTNNSIEERKDFVHQFNMELLLPHLEWNRQENGREDKAGTCRNYTWNLKRCPLDALVAHGTDISHSLRHAWEIGLTNWEKD

    GDKHRGKAELIVKTINLTTGPWVSEELLNCNSKYEKLFQLSNYLYHQLGHFNKNKVDDKKKYTTPEIESSMQELAQLVLQNSSDGLDSNIKQTFFTVVKSIYYTTVCDLGTTNYHMS

    KVLFERVY

    > Oenothera-californica-subsp.-arizonica_ linalool synthase-like protein

    IPWMARMDHLEHRRWMEETASNTLLWMGKSSHHRLSCLHNDNLLELALKDYGLRQSTYLTELQQVKRWSKERSLCDLGFGREKTTYCYFACAASTSLPYNSDIRLIVTKAAIVITVA

    DDFFDTKGSLDDLEKLTDAVHRWDVKGLDSHSKTIFEALVDLVAGIRMKYLQQNGKDI

    EENLQHLWYETFKSWLVEAKWARVRSKPSVDEYLRNAMISIAAHTLVLQASCFLGFPVDNQLWSTPRQEITSLLMVTTRLLNDTQSYLKEEDEGKINYVWLYMNENQQGKIEDSIQH

    VQALVNMRRQEFLKHVLSPADEQHCDQQLPKSCKQLHLSCLKVFNMFFNSSNLYDSET

    ELLLDIDKAFASPPNVDKFMLSPQYHPLPPLFLHPPHQVVKKRGAKITNYKNPALVKNYPWRKGFTLQHPISRFGATIRIRDILAASKMKLCFN

    > Clarkia-concinna_ linalool synthase [Clarkia concinna]

    MQPITKSSSTSSELEFLVDKVKRESLSSSSSDTQNLFLSASPYDTAWLALIPHPHHHHHHGPPMFEKCLQWILHNQTPQGFWTAAAGDNISDTDDDVTLDCLLSTLACLVALKRWQLAP

    DMIHKGLEFVHRNTERLVMKQKPSDVPRWFTIMFPAMLELAGASGLRVDFSENLNRILV

    ELTQNRDDILTREEVGEKKQYSPLLLFLEALPAQSYDSDVLKQIIDKKLSSDGSLFQSPSA

    TARAYMITGNTRCLSYLHSLTNSCSNGGVPSFYPVDDDLHDLVMVNQLTRSGLTEHLIPEIDHLLLKVQKNYKYKKASPKSLYGIAAELYKDSLAFWLLRVNSHWVTPSIFCWFLNDE

    EIRDHIETNYKEFAAVLLNVYRATDLMFSGEVQLVEARSFATKYLEKILATGNIQKTNA

    DISSSLHKMIEHELRVPWTARMDHVENRIWIEEIASGALWFGKSSYLRLSCLHKINLQQLAVKNYTLRQSVYRDELAEVERWSKERGLCDMGFGREKTGYCYYAFAASTCLPWSSDV

    RLVLTKAAVVITVADDFFDVEGSMDDLEKLTDAVRRWDAEGLGSHSKTIFEALDDLVN

    EVRLKCFQQNGQDIKNNLQQLWYETFHSWLMEAKWGKGLTSKPSVDVYLGNAMTSIAAHTMVLTASCLLGPGFPVHQLWSERHHQDITSLLMVLTRLLNDIQSYLKEEDEGKINYV

    WMYMIENNQVSIDDSVRHVQTIINVKKQEFIQRVLSDKHCNLPKSFKQLHFSCLKVFNM

    FFNSSNIFDTDTDLLLDIHKAFVSPPQVPKFKPHIKPPHQLPATLQPPHQPRQIMVNKKKV

    EMVYKSYHHPFKVFNLPKKQSSGHGTMNPRASILAGPNIKLCFS

  • 8/6/2019 KristinaMarieTurnerGossypolBLASTMatchSequenceHomology

    18/24

    > Pyrus-pyrifolia_ alpha-farnesene synthase [Pyrus pyrifolia]

    MEFRVHLHADHEQKILQNQMKPEPEASYLINQRRSANYKPNIWKNDFLDQSLISKYDGD

    EYRKLSEKLIEEVKIYISAETKDLVAKLELIDSVRKLGLANHFEKEIKEALDSIAAIESDNLGTRDDLYGTALHFKILRQHGYKVSQDIFGRFMDEKGTLENHH

    > Clarkia-breweri_ linalool synthase 2 [Clarkia breweri]

    MLSIQSHVDEIKRGSLWNLRLSPSAYDTAWLALIPDPDDPTRPMFAKCMHWLVQNQSMEGFWAADDDIDTEPVALDCLPATLACLIALKRWGAAPNNINKGLGFFERNVEELLLRKG

    KLSDVPRWFTVTFLAMLELAIASGLKVAFPDNLIKVLDELFENRNTILLREELSDKTQYA

    PLLMFLEALPPSYVKLDDLNQYLERNLGNDGSLYQSPSATARAYMATGNTKCLSYLKSLTNTYLDGGVPSLYCMDEELQQLVMVNQLVRPGLTEYFVPEIEQILLQVEQNYKCKRSP

    PPRNALHNVVAELYKDSLAFWLLRINGHSVSPSMFCWFLHNNEIRHHIEANYMYFDNV

    LLNVYRATNLMFLGEAEAEEARSFSIKYLNKITQQKVQTPITTNIHISSSLQRMIEYELKL

    PWTARMDHLEHLMWIEEAASDALWMGKSSHHRLSRLHNLDLQQLKLKNYTLRQSVYRNEHEEVKRWSKERGLCDMGFGREKTTYCYYARAASTSLPCSSSVRHLLAKAAIVVTV

    ADDFFDEKGSMDDLENLTDAVRRWEVEGLSRHSRIIFEALDDVVNEIRLKCFQKHGKDI

    KDNLHHLWYETFNSWLMEAKWGKGNIKPSLDVYLQNAMISVAVHTMLLPVSCLLSPV

    FPVHQWSARHHQDDDDMTSLLLFTVRLLNDTQSYLKEEEGKINYVWLYMNEKEKVKLEDSIQHVQSLINLKKQQFVQHVLTNSHLPKPYKQLHLSCLKIFNMFFNSSNLYDSHDDTH

    LFHDIQKAFIIPPQVHKFKPRYAKNPQQEATTSAAATSSAAPTTSDQYASQGL> Mirabilis-jalapa_ >gi|46949202|gb|AAT07457.1| terpene synthase-like protein

    LPSSEEYLKNGIISSSLLVVSTLLFYLLGHGRNDNNIIGLNKYLDMATSTATILRLWDDLG

    CAKDENQDGNDWSFIECYLKEHEGSSIESARETMNMLISNAWKCLNEKCLSHHHFSQLI

    EACLNLARMVPLMYSYDDDHRLLDLERLIQV> Chlamydophila-pneumoniae-CWL029_ CHLTR possible phosphoprotein

    MKKLYHPTLFLRPLIRLSLIFALSLTLISGNFPQQKSFGHCCADMHSALISGKNCEELFAD

    FIERVLADRETLTARDWGTVVVLVREYLLKCIRKGDCDYGVKILQKLLALRLPKDARKDLQILWHRLNPEQAPLRDVVDQLFTIGCHESLQDHLLFELYTVTLHSGYENRKQDMLLA

    KEQGDYKKAIELAKELVAALEKGSCSPHPEIVQIEKTFLQKTLLALQIKVAQEAQESCDA

    LLTPYCLSEIAYTEAMDALVLRIARGEVSRTNEVDSVLLSHALQHLPFAREKAIPELEVLIDHGAYLESTLLYYAYFSLLELYHQNKDFASLERLLEKGDAVFVPEHPYFPEYGFFLGAY

    FYAKGKYESAEKVFLQIIDPAVKLGATFARAYEYLGCIAYVQNHYEKAEEYFLRAYKS

    WGREESGIGLFLAYAVQKKKTACEDMLYHPKFSFTYRHLLDSLCSLSYPHGENKGSSAIQRVHRAVPELSEIYSRCIYDMIKYRNVTYTHPIIELAYNQVRNLEKRNLEEICRDAQDPE

    YDKALAFWGALQSGASVPRSLIESSDVDEARITIRCYEALYFHNPDAIAMLPQAFSEECN

    SWQTALRLVWTLVRPKGAPNHAKYWDHLVLRPHGDSLYFFGYDLQEYLIGKEDALKH

    LSVFAELFPKSSLLSLVYYLQGYSESSALRKVGWFVKALEEFTEISWSGEHMKTWAYIYYMVKLDLADTYISLGNFSQAVHILEEVKEDWQVASHPKLHFLKGEDCYLAMELRWVE

    GLAYAYFQLHETAHLSNHLLEHVEKNLISPRSYRDYYGESLQRTLGLCQRFLGV

    > Actinobacillus-pleuropneumoniae_ xIIID [Actinobacillus pleuropneumoniae]MKLWILGLGEFFQRYRNIWREIWKIRKQLDTPARQKDENEFLPAHLELIETPISKKPRLIA

    YLIMLFLFLAIVISIISKVEIVASATGKLVFSGHSKEIKPIENALVKDIFVKDGQFVEKGQLL

    LNLTALGADADKQKTKVSLGLERLDGYRYKSLLYSIEHNRLPLLDFNQADFDSVQEEDKTNTRHLITEQFETWQKQKYQKELAYQRKQAEKQTVLANIRKYESASRIEKEKLSDLKK

    LYDVKSISKHELLAQENRYVEASNELSVYQSHLKEVESDLLKAQEDLKLVTQLFKSDIL

    KLQQNIQREKQLTLELEKNEQRQLASIIRAPVSGTVQQLKTHTKGGVVTTAETLMVIAPE

    DDVLEVSALIQNKDIGFVEIGQEAVIKVETFPYTRYGYLYGKVKTITLDAIEHPQLGLVF

  • 8/6/2019 KristinaMarieTurnerGossypolBLASTMatchSequenceHomology

    19/24

    NSIIEINKKTLTDGDKEIQLGSGMSVIAEIKTGERSVISFLLSPLEESITESLRER

    > Actinobacillus-pleuropneumoniae_ RTX3D_ACTPL RTX-III toxin determinant D

    MKLWILGLGEFFQRYRNIWREIWKIRKQLDTPARQKDENEFLPRHLELIETPISKKPRLIAYLIMLFLFLAIVISIISKVEIVASATGKLVFSGHSKEIKPIENALVKDIFVKDGQFVEKGQLL

    LNLTALGCDADKQKTKVSLGLERLDGYRYKSLLYSIEHNRLPLLDFNQADFDSVQEEDK

    TGARHLITEQFETWQKQKYQKELAYQRKQAEKQTVLANIRKYESASRIEKEKLSDLKKLYDVKSISKHELLAQENRYVEASNELSVYQSHLKEVESDLLKAQEDLKLVTQLFKSDILE

    KLQQNIQREKQLTLELEKNEQRQLASIIRAPVSGTVQQLKTHTKGGVVTTAETLMVIAPE

    DDVLEVSALIQNKDVGFVEIGQEAVIKVETFPYTRYGYLYGKVKTITLDAIEHPQLGLVFNSIIEINKKTLTDGDKEIQLGSGMSVIAEIKTGERSVISFLLSPLEESITESLRER

    > Plasmodium-yoelii-yoelii_ hypothetical protein

    MINHSKNKNTENKIIEIIRKNGDTNTNKNMYNTKLVKNGLAKCEDELIDTNTVEENINHI

    EKSMNKLNEIENKIIDNINECNKFIDFYERSKSLLDSKDFDSDVGREQEIEQIRKVIKRCSTNLTSEGIFLTGPSGQGKTYSIFYIIKEIEKEKQEMNNYNNNKKNKKENTIIPNYKNIDSSYF

    YVSCSNSQKPYDIFADILQQIINNKNKKIILNTVKQKYNLNGLEEVKKLFINYTSKFNNLK

    IVIVDELDFIATKNVRTELKTKNNTKNSNEDIVKALFECVQNSKCKIILVGIANSLDLIKD

    YTHMKINQIIYKPYNEHQFMHIIRNKLNTLEDELINKIFKGVSLNIHLRQISNQNGEYTINVLMLF

    > Lactococcus-lactis-subsp.-lactis-Il1403_ transcription regulatorMARIALTRDKIVQATIELAGKIGLSNVSFPRLAEYFGIKAPSLYNHFKNMEEVRVATAVY

    LQKELNCELTHAMVGLTPLAALRAYAESYKRFAEKYEAVYELINVIHQTNNGELEYLA

    KENIRLVRRSLENFHLSEEENFHISRMFRSTLHGFITLTQLGYFRQSGSISKEESFTYMVD

    HLLSRLDNPENI> Hordeum-vulgare-subsp.-vulgare_ ent-kaurene synthase-like protein 2

    SSVNELGSKASAVQWQELLRNMMTEVEWRTSGYVPTLDEYIENAVVTFALGPIVLPAL

    YFVGPKITESMVIDPEYSELFRLMSTCGRLLNDVQTYEREYKEGKLNSVSLLVLHSDGSMTIPEARMKLQKPIDTCRRDLLRLVLREDNVIPRPCKELFWNICKTCYFFYYEGDAFSCQ

    EEKAAVDAVIHDPLQLPMNLLSTSIYHFAXR

    > Lactococcus-lactis-subsp.-cremoris-SK11_ COG1309: Transcriptionalregulator

    MARIALTRDKIVQATIKLASEIGLSNVSFPRLAEYFGIKAPSLYNHFKNMEEVRVATAVY

    LQKELNHELTHAMVGLTPLAALRAYAESYKKFAEKYEAVYELINVIHQTNNGELEYLAKENIRLVRRSLENFNLSEEENFHISRMFRSTLHGFITLTQLGYFRQSGSISKEESFTYMVD

    HLLSTLNDKHSI

    > Gallus-gallus_ PREDICTED: similar to RIKEN cDNA D130067I03

    MGKAQKAACVRPYRENFVKNVELQGYSAMKRGTALILIVQVLRNGEKFDRKAGTWLDTVFKAKEIQIGQLLAAEGRTEDAVLLSVHPVCTQFASLTRDSAWALQYPHLSSSVTGAD

    LAGNEVAMLAGLPVVCPTECQEHWADDMDAEKDGVKQLISSFQVGCEGAEGSLKPSA

    VRQQCCVIQDSWRWLREVLICCSFCRNIHQGNRNGKGDTISTSPVSYAVLQTRATPSLPFMKEKHSLVASEEEKIQPSSRPSSFLSWSGDVMHEHGWARNGKRRGCEHFILPGMTLQRL

    SVLLQTLDNTGEVILRAPSVMLECVNRSATKRKISELAVSSSCPSDSSSASLGCVPSAPCS

    WLTLFAWDPMAVLCWNAGRCVHITVLYPKDELRVQKVGGCVLSAVHGDCNADGTGGAAPPQLFCVRSEDGHGWRCLLLEKPSVADAQHQQGLFVWGPLQLISTCEYHPITVNFLR

    SVFVLLLVLRKEKEKDDNRGRMTGLEQNNLLYQLRGGGHWGRCVGDCGSGGTRSRAV

    WCTHTEGWTSHHANCDQQEKPESQRRCFKVCDWHLELFEWDVSGWGSCEPGGEAGP

    CVMAQHGLQRRSARCLQKLDRSVVAAEICEHLAPQPPLEQACLVPCPRDCVVTDFSPW

  • 8/6/2019 KristinaMarieTurnerGossypolBLASTMatchSequenceHomology

    20/24

    SPCSGGCTNSLRHRTRAVIAPPLYGGAPCPNLTESQTCAAAACPLGEEEHTYSLKVGPW

    GECRLPHREDASLDLGEDSGELSTSWLEGHKAQHHPHTGQVGYQTRAVSCVRSDGRHA

    VLRVGKSLTVSNWRLEKTNLKRVHTEFTCALNFGECLCVQDAVPLTSKTCVIAKDCETSEWSAWSSCSQTCSWGDLAPGFRSRHRSVRSVAMGSGKLCPELEEKEACSTGGRELLKP

    CPRFSWRTSEWKACQVSLFDQQSPQHHKHAVLCGGGIQTREVYCVQITVEGETHRLKE

    VCCNDDFQHLVANEVHILENPLFSSFSRPVDGKFCLGPAPSASQLCDLPCPLECAVSAWLAWGPCLPEDCRDRQGRRGNGFSCLFLVAVGSEAGFRMRQRHVIVDPVGTLTGCPHLVE

    SIPCEDPTCYEWIVSEGICVADHGKCGPGKHILKTVCKNKKGLPTQILVCVETQEISGPLT

    AGLSSEVVMRKFNLRFSIWAAKHEFVQFLSGSCICALPSVTAYWFLVCSCLCWSVIVQLLMKSTESGSILCPWYFVRTAHLLTPSMLSQNNSIIFERLCKLCGFGCLGDLLPALLLVAG

    CHTQLACQDMLTADDSQAENLYFILLDKVFRYEVSGSVFGGGQEICVRDVCVVGTEQV

    SRSLTSVWVCSPLGIQCLATNGRSASLGSGVIGHHVAVFPGEEVPYHLCSELPRPDVMA

    CEIPCATDCVLSEWSQWSPCSHSCSSKSAEGSQSRSRSILALPAEGGKACPPDRALQEHRACNDHPCVHFFWETSPWSSCSEDVLVTALNATVSWSGEATCGVGMQTRKVFCMRSGS

    GHVTPKRCPDSTRPETVRPCLLPCKKDCIVTPFSEWTRCPTVCQPGNATAVKQSRYRIIIQ

    DAANGGQACPDTLYEERECEDIPVCPVYRWKTHRWSHCVLVPESVRQNVLGHNEACG

    HGLQSRVFVLVKEKPELEVLPLNSFSTCGVAVTCLTENNESADVSECMKWAGPMPPLVQDCLIPCKDDCTFTPWSKFTACSFDCESTKTRRRSLTDMYLFMRVDQKALMDCLLTHTS

    VQDPQGVFEDVIQMQLLVKMNLPFCLDAKYKDIPELRQRRSRKRDKCQNTEVYPQVETELCPCEVFTSQPHGNWSDCIIGGGKLELQQGVQSHGDTKECGEGVRLRAIACYDKAGRL

    VEPSRCSSSGYVEESCTVPCPFDCKLSDWSSWSPCSSSCGTGMKVRSKWLKEKPYSGGR

    PCPKLDLKNQAPAISNANDWDSSLIEKCFQVRHSLLPAVPFQGLVYAYDQLSVIAVNKS

    AHIRFLGGYPLHVGIQKLVFENIIRNALSINSSCINVFFYDTVCQLSEGPCVTLFRRQPSSNASRLFLSSVTCCCISDTNCGRSLAVACEGTAELCVPPALSISARLLCWFEERKEILSSSYSC

    AGLAPSPGVPVVASTLRKQLHIQLSGRARRGACWEFCAPPTSAESSECEEPWAPRSAFSH

    SVGVQLKWMDFPEAPQKVGFGLVGVLSDLLCKLEEQLWRCCGGQLMQVSNCQRRNNLLKSNDSAFQSGNGSFGPIGAGFDLQKGSALAGQRQWAMLGTLISSTQLSFSVGCVYEA

    VPCYTECNQYSWVVEPWSPCKINSEQNSLHCGEGIQTRKVRCVSTTEDHGGETVPNTLC

    NKAEIPNEIRKCSLYCPNECAVSDWGPWSTCPQLSQGKVAAKNGHTLVNTVSYKGNGVNGVSHFTFKGRATYSQLNNSIMAERLDRGLAKKTPKYKSLHLEPNLILVCDPSTVQTRT

    RQVLRSVSRKPCPEDSQMKPCILNQNCFQYQYNLTAWSTCQLNGNATCGRGVRKRLLS

    CVRSDGETVSARHCEQRRLEKPAETSSECVVRCVVDCRLSAWSAWSQCSQTCGSGARAELQQGPEPTEVFSALQKWTSALLSFWETLFVETFMTAVPKMKLKKFSPIINRILMEMAEV

    VMDGQMVRGRTVLLKAAAEGRPCPAQLSQHRSCPVKPCYSWHLGPWSPCRLQGGQCG

    DGLQFRNLTCVVHDASVSATSQPVEDALCGELPLKESVLQLPCSVPCPDLRFVLSLHAG

    DCHLTEWSEWSSCELTCIDGRSFETTGRQARSRALIGQPAENTESCSGQVVETRPCSGGRCYEYLWKTSLWRDNVRTVWCQRSDGVNVTDRNHSDCEIPAGAVTYKFFLHRMKTEIH

    GQHFEAVQEVGKGGCALQTKPAEVRHCSPACRKPFSYCTQRGVCGCERGYTEIMRSNG

    LLDYCMKVPGLEDKKADVKTIAGKNKPVNSKMHDIFKGWSIQPFNPELTELGPQPFKVGWFLTKLIVQKPTQFTSCLSRSKKSKQHQSTPPQQKPLTLAYDGDIDM

    > Brassica-napus_ 1 cyclase ent-kaurene synthetase A

    RTFLFSPSSTAFAFMQTRDNNCLKYLRNAVERFNGGVPGAFPVDLFEHIWIVDRLQRLGISRYFEEEIKECLDYVHRYWTDKGICWARCSHVQDIDDTAMAFRLLRLHGYQV

    > Plasmodium-falciparum-3D7_ hypothetical protein

    MVPLYEEAGIIMDDVSGVILFYEDVINEMKGSYNSLYDNMILLKNKMENIKEQNKIIIKE

    NDSKEKYFNSSNMLNDILCNKLGLINMTTENRNNEGVNDRENNNNNDDDNNKYGDNN

  • 8/6/2019 KristinaMarieTurnerGossypolBLASTMatchSequenceHomology

    21/24

    KYGDNNKYGDNNKYGDNNKYGDNNKCGDNNKYGDNNKYGDNNKYGDNNKYGDNN

    KYGDNNKYGDHNNDYYYNNILSFQNKPLCYNNQLKKYDSKIIKLDENIFNTLKEENEM

    GSNNGKDISTESSKDERSNVNMDDIYSDNFLNAESSINSNKVSPIILSDENKKLSNFLKEKKREYQKIISSNKKEDVLNILSDANNEDNTQKEINNNNNNNNNNSNNNNSNNNNSNNNN

    SNSNLYGYDNNKFVPPCTKGQNINGTHMFTQEDDNKKDEKKYGIHYSIKKNTKIYRED

    MKNYKKSTNSKNNSLLHDNKKKKKKKKKKKNKNKNNKMNNNIYNNMKNKMKEIFNFMNNIYNNKQINNCYEDHFPFFLLPKEDSMILENMELYLSSKYNKESSHKSCNPTNNIQE

    YNNKYINDENDIDNLTNIQDSISSFGKKLNYINESNETIRNYSINNLCKIMNEDNQKGFNK

    NSFIYNDKNKNINYKGENNMNIHNSNVYENKYEMNFDNKNEKFNIPNKRYIYLNGDDSNYKKKKQRTNKKKIQNNSNISNNIYTSSSVGCPHCTCITHKNISMTRGKTYSYYSDESNQ

    HTNNLIKFMNPKTIMSNKLISNFIDIDRNPIFVPAYNQRYGVLSDVEEVEQKEKKNNNNK

    KIKKIKNKKKNKKKKNKKINKKINKKINKKINNGTVKLTFDENVNKTSFEKDKENILDTI

    INNNDDNNNDNNYLCMDTIMSTSNNSHSCNDSDLKRYDKKNDHVTDSFKNNKNDKELCKNKNLLCNKKDRNKNKMITEGIKDDSNIEKKRKRGNHQKYEEVGNDINQKKRKDKES

    LLYVNNNNNDQINDIILNDVHHIKKYELRRQKKITYILPSLNKKLRRDSCRLIFDPFGYNN

    TWKIKTT

    > Photobacterium-profundum-SS9_ putative ABC transporter, ATP-binding prot.MTIEFSNFTFKYWALEKPTLKNINLTIGKGEKVVIVGPSGSGKSTLGQCLNGLIPFAVKG

    DCSGSLKINGKDTKSLDLHQCTNIVGTVLQDTDGQFVGLSVGEDIAFALENQMVIQEDMHTIVKDTAKMVELDDILDVSPFDLSGGQKQRVSLAGVMVDDVDILLFDEPLASLDPKTG

    KAAIDIIDHLHRDTGKTVIIIEHRLEDVLHRPVDRIIMMEQGEIVANMTPDQLIASDLLEQ

    HGIREPLYISALKAAGCQITEDDKPAYFSTLNLDKFKPQIENWYHQSFVACTPENSERLL

    TVNNLSYSYDGIKNTLDDVSFHINKGEFVSILGKNGSGKSTITRLIMGVLEPDTGSIFMNGQDLAQSSIFERSQKIGIVLQNPNHMISHHMIFDEIASGLRNRGINEATVERKVFDILELCGL

    KKYRHWPIDALSYGQKKRVTIATILVLEPELLILDEPTAGQDYHHYTLMMEFVRELNRK

    LGITILIISHDMHLVLEYTQRAIVIANSQLLADAPVNTIFSQPALLEKANLTVTSLYSLAHAMGIERIDNFIHCFIEHEAKNK

    > Caenorhabditis-elegans_ ATP synthase subunit family member (atp-2)

    MASRSLASISRSASRLLQSNVQKCALPAASIRLSSNNVESKKGIHTGVATQQAAAATKVSAKATAANASGRIVAVIGAVVDVQFDENLPPILNGLEVVGRSPRLILEVSQHLGDNVVRCI

    AMDGTEGLVRGQPVADTGDPIKIPVGPETLGRIMNVIGEPIDERGPIASKNFAAIHAEAPE

    FVEMSVEQEILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIEGGVIDLKGKNSKVSLVYGQMNEPPGARARVCLTGLTV

    AEYFRDQEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGSMQERITTT

    KKGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSRGIAELAIYPAVDPLDSTSRIMDP

    NVVGQNHYDIARGVQKILQDYKSLQDIIAILGMDELSEEDKLTVSRARKIQRFLSQPFQVAEVFTGHQGKFVSLEETIRGFTMILKGELDHLPEVAFYMQGGIDDVFKKAEELAKQHGN

    > Legionella-pneumophila-str.-Lens_ DNA polymerase III, beta chain

    MFELTIKKEDLLTPLLTVSGAVDKKQSLAILSHFLLKLSDGLLYITATDLEIEMSAQVACDSKNTSGSITVPAKKFIDIIRSLDENASPSIVFDKALVTIKQNRSTFKLATLPAENYPSSEDE

    CNDVELTIPRLVLLQLLQSTHFAMSQQDVRIFLNGLLLEFDSNIISAVATDGHRMAISRYS

    CNNITQKKLLIPKKGVQELLRLLNCINDEQVLLTAGKSHIKLITNQFVFLSKLIEARFPPYTKAIPREQDKCIVIDCASLKRALSRIVILAHEKSKAVLLHLQQGQLTLIANNNEQEEAIETL

    AETQGDELKIGLNATYLLDVLTHFSEGQIRLSMSNTESSILIESLINDNYQYIIMPMKI

    > Plasmodium-reichenowi_ reticulocyte binding-like protein 3

    MRKGLIYRAILCNILLILIEKSHQNNIYKVNGNNENFQFSHLNFYSKNNEGLNFGKRKVS

  • 8/6/2019 KristinaMarieTurnerGossypolBLASTMatchSequenceHomology

    22/24

  • 8/6/2019 KristinaMarieTurnerGossypolBLASTMatchSequenceHomology

    23/24

    LLNEEYVNGSKDNTKNSNNGRDRFNYNYYSNKGFYYTQIKYASGFVIGLIICSSVGYIFR

    KEINISEVDFNGNVQDFHFIKANNLRDKDEIVEAPFNANDYI

    > Campylobacter-lari-RM2100_ Capsular polysaccharide synthesis protein sup.MQIYQNNHLLYNNLTKKLSTFIPIKPIRRKLRNHIQYKLEHPKVASYLSNNYINPFLDGKI

    PHFDFEKKHHFKNDKIIWQFWYQGKDQASPMIQQCFNSIQNQMKDDYTIIILDKDNIKD

    YLVFPSFVIEKLENNFFGEKTITFFSDLLRVCLLATYGGIWCDASIFLSSKIPSELCDKDFFTFERSKTKPSKEKLKKFIKSGYFSYGYFNWNDDFKVKMLSSFMIAKTSNTFIQTLKDILMN

    YWKNEQSSENHYYFVLHIIFELLKEHGFVNDTYKNMSDIECHLLQFYAKEKFDENLWKS

    IQKQSFLHKLTHFKSIKKDSMIDKIILQS> Brassica-rapa_ 1 cyclase ent-kaurene synthetase A [Brassica rapa]

    QDGSFLFSPSSTAFAFMQTRDNKCLKYLRNAVERFNGGVPSVFPADLFERIWIVDRLHRL

    GISXYFEEEIKECLDYVHRYWTDKGICWAKCSHVQDIDDTAMAFRLLRLHGYQV

    > Legionella-pneumophila-sub.-str.-Phil.-1 DNA polymerase III beta chainMFELTIKKEDLLTPLLTVSGAVDKKQSLAILSHFLLKLSDGLLYITATDLEIEMSAQVAC

    DSKNTSGSITVPAKKFIDIIRSLDENASPSIVFDKALVTIKQNRSTFKLATLPAENYPSSEDE

    CNDVELTIPRLVLLQLLQSTHFAMSQQDVRIFLNGLLLEFDSNIISAVATDGHRMAISRYS

    CNNIAQTKLLIPKKGVQELLRLLNCINDEQVLLAAGKSHIKLITNQFVFLSKLIEARFPPYTKAIPREQDKCIVIDCASLKRALSRIVILAHEKSKAVLLHLQQGQLTLIANNNEQEEAIET

    LSAETQGDELKIGLNATYLLDVLTHFSEGQIRLSMSNTESSILIESLVNDNYQYIIMPMKI> Magnaporthe-grisea-70-15_ hypothetical protein MG04428.4

    MSNPRRTPMTRPDSVLPLKTTLAVLTKGSTFSPISPATPKSSSSFTPPSLPTRSHTDLDDVV

    DAHRRRVALTLGDIEKTLAGMSLDSPSANKAFRDNSYPLPRGLLDPTLIGKEMDVERRV

    LRPRPVRRPGQSHHHESDSGLGSSILSTKQKSTPNADSTPAKTGVKGSAVTRSAASSTSKNLPSLSARATNRVFEHTLKPLLADSSFKEFHPVLLECPRKIQSKQIVCLRDVEKTLLLTAQ

    CIRATVVYLSETEQRRPKDVPYSSGYFIDLVDQIKQYAQQLADQKKAGASDPNIKEEVK

    LHGGIAVNGRPAELVRISGGKAISLATGEPVELDEETTSPIRFKRSASQQLADDDEIMRSMARRKKNAPPEEYAPKMCREPGCGKEFKRPCDLTKHEKTHSRPWKCPVPTCKYHEYGW

    PTEKEMDRHHNDKHSAAPPMYECLYKPCPYKSKRESNCKQHMEKAHGWTYVRTKAN

    GGKKIDSNPSGSVTHATPQLTNMPTPPSDNGAFAGLATPPMEYTMPAYNNNIEFPTYVAQDQFQIQFPQELSLDYSPSAPSDHATPSSHSNVSGGSPFQSPYQDPGSDFTVYDDIYNAN

    AQVQMQNPFSEKDAAQFLAFVTNAEFQTTKAAPVHFSPTGQGNTMLFTPSTLADYDES

    FDDFQNNAQMGADFCLFPANGVKQNSPAPLFGEIPSVAAGYSQPTSQELLPNDWRMNQYQGLGFSQN

    > Entamoeba-histolytica-HM-1:IMSS_ Viral A-type inclusion protein rep.,put.

    MSRRTGIQLGARRKAEPQTTPKPEDKQPDVMPPPPSGEAPVPEHRERKASFLTRPKKGV

    NTNDSEQQDPPTQQPVEKVQQRKGFLSRRSETQSQTNELVSTPPHEKSGDEAKNEQKQSSSQTSESTEKETHKKRLSFLGRKSFSKRNSTENTGHSSSEHSATSSLASETTAEEVNRSVN

    AQIEEENKRLQNENEELKKKCDAQDSLLKTKMKSEMEAKKKVEILENEKKDLIDKMAN

    ENDGMSKLNEELTQIKNEKESINNELIQTKQEKESINNELTQLKTDNDQKENELNQVRHEKDEVIEKFNTSKEENEKIMNELSQLKQEKEEKENELKEQVKKMEEEKSKLITELSNGSDG

    ISKLNEELTQTKQEKEEINNELNSIKEEKKRIEEEKNQIINENKEIKEEKEKIEEEKKELLKE

    IEKEKEGNNQLQNEINTIQTRMKEIEEKNQEIICDNNKEIAKFKEEQENLQKELNQIKEEKQKTENEKNELVDVKTQKENELNKLKEEKEQIFNEKTTIENSLNQIVEEKNKLTEEKESIK

    QELDSIKADNSTKELEINKINEEKNQLQNDYDTVQQEKENIQKELNQIKIEKSQKEEELN

    KIKEEKQQVEDEKAKLITDIANGNDGLTKLNEVIDKLKDEKENISNELNQIKNERDNISN

    EFNKTKEEIKQKENETIQLNEEKSVLLNELNQIKEEKQKIEDEKAVIQQEKENEITKLNED

  • 8/6/2019 KristinaMarieTurnerGossypolBLASTMatchSequenceHomology

    24/24

    KTVIENELNQIKTEKQEIENELNQTKDEKQKIEDEKSKLITELSNGNDGISKLNEELTQTK

    QEKENVLNELNQIKNEFASFKEQNTQKENELKDENNKVQQELEQKNNEVSKLEEEKG

    NISNELSNTKQELEQKKQEIITITQEKEEKENELKEQVKKIEEEKSKLITELSNGSDGISKLNEELTQTKQEKEEIQKALEEEKEKLERIETELKEIKEAKQELEEEKNKTIEEKTNLQQELN

    ENKKIVEELTQTKQEKEEINNELNSIKEEKKRIEEEKNQIINENKEIKEENIKSIEEKTQEIN

    SLTTSIEELKGRLEESKGERIEIEKERDRVISELNDIKLQNEGMKKQVEEAHNRMTEMQKSFEGSENEMINSLNNQITQLNEKEKQMNEQVMALQTQLSQSNINLEEVKKDLIESQNKY

    TQINEEKDCVEQERNKINEEYKTVNEELEKNKKELNDLQTKYDNEILELNKNKDELNSLI

    NNLKEEKTNLEEQVKKMEEEKSKLITELSNGSDGVSKLNEELTQTKQEKEEINNELNSIKEEKKRIEEEKNQIINENKEIKEEKEKIEEEKKELLKEIEKEKEGNNQLQNEINTIQTRMKEI

    EEKNQEIICDNNKEIAKFKEEQENLQKELNQIKEEKSKLITDLSNGNDGLSKLNEEIETIN

    KEKEGIRKELESLKEENNKIQDELEQKNQELSKVKEEKEKLIHDLTNGNDGINQLNEDLN

    QIKNDKEELTEKNVQLQNEINKLKSENEELSNNLSFEKEGLKQVNEEVNAIKEERDELVKQIKKIEEEKRKVEEELNFNGSEVNEQIAQINNEKEQLNQECNELKQNLKELQSKIEEIEQ

    EKESNEIKKKEELQELQEEITEKDNDIKNLKEEIERIEKELQEKEEDMEQMSNNTEELEEL

    KNKLTETQRLLEEEKKEKESISNEFEETKEQVLVELQRVNNEMNKMNEIKQEDENEKEE

    LQEHINKLKSQIERENEQLKEVSKLKWELSELKTENESMKQMIMNKKSLLDNTDDFILMSLEYLYFDSVWVTLKMELLDEEDLDDSIGDRLGINTLKLFKICYNSTTFNNYRDWLLQYI

    KGEISI