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Aging 2.0 

BrKenn

Buck In

for Res

on A

Extend

healthy ye

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Lifespan Expectancy is on the

Lancet 380:2071

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Science, 2002

The Silver Tsunami

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http://unfpa.org/ageingreport

By 2050…

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Rates of Chronic Disease wit

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Life Expectancy Throughout His

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Why Aging Is An Issue?

Increasing

Healthcare

Costs

Quality of Life

Societal

Impact

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Aging: Cost vs. Return?

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Aging: Cost vs. Return?

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Aging: Cost vs. Return?

.Russia

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Why Aging Is An Issue?

Forbes

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Healthy Life Expectancy – HEALTHSPA

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Healthy Life Expectancy – HEALTHSPAN

- 0.1

- 0.2

+ 0.8

+ 0.7

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• Lived until 99

• Health problems at 60

• 101 in March, 2013

• Still lives independently

My Grandmothers

LONG LIFESPAN!

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S d d l

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Standard Drug Developmen

State-of-the-Art

Basic Science

TreatmentsChronic Dis

A i i d i i f i CHRONIC

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AGINGStroke

Arthritis

Catar

Frailty

Heart

Disease

Type II

Diabetes

Cancer 

 Neurodegeneration

Aging is a driving force in CHRONIC

Th F k f h B k I

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State-of-the-Art

Basic Science

TreatmentsChronic Dis

Extend

Healthspa

Prevention

The Framework of the Buck Ins

h f i

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The Impact of Innovation

Courtesy Steve Burrill

Burrill and Company

Buck Research Approach

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 Buck Research Approach

A i i i

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A Healthspan Initiative

Risk Factors for Disease B

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Risk Factors for Disease Bu

A Potent Anti Aging Device

The Power of Exercise

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 A Potent Anti-Aging Device

The on-going “Stanford Runners Study”

Started in 1984

The Power of Exercise

Qin Shi Huang (秦始皇) (259 BC 21

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• Unified China

• Great Wall, Terracotta Army

• Died due to ingesting mercury

meant to make him immo

Qin Shi Huang (秦始皇) (259 BC – 21

Aging Model Organisms

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Aging Model Organisms

Identifying Conserved Ag

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http://www.pathology.washington.edu/research/bioage/ellison/

Matt Kaeberlein

Peter Rabinovitch

Warren Ladiges

Stan FieldsGeorge Martin

Identifying Conserved Ag

Pathways

The TOR Pathway

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The TOR Pathway

Rapamycin

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Rapamycin

The Drug Rapamycin Extends Li

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The Drug Rapamycin Extends Li

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Rapamycin and Age related Di

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Rapamycin and Age-related Di

Rapamycin: The Good and the

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Rapamycin: The Good and the

TORC1 ifi i hibit

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TORC1-specific inhibitor

The

wit

The

Th Fi t f M

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The First of Many

Why Aging is an issue?

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Why Aging is an issue?

HEALTHSPAN vs. LIFESPA

Impact of aging research

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Impact of aging research

for human health

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Google launches Calico, a health c

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Google launches Calico, a health cfocused on extending life

On Wednesday, Google Chief Exe

announced the launch of Calico…

Calico will attempt to tackle the u

of aging and related diseases.

"These issues affect us all -- from

mobility and mental agility that c

life-threatening diseases that exa

physical and emotional toll on ind

families," Page said in his post on

while this is clearly a longer-term

we can make good progress withi

scales with the right goals and thehttp://www.latimes.com/business/technology/la-fi-tn-

google-launches-calico-20130918,0,4770326.story

Thank You

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Brian.Kennedy@buckinstitute.org