kisspeptin hope about to become reality
TRANSCRIPT
Kisspeptin; a hope
about to become a
reality
Owen Harper
Dr waleed tawfik
Ass.lecturer OB &Gyn
Benha university16/4/2015waleed tawfik,benha university
waleed tawfik,benha university 16/4/2015
waleed tawfik,benha university 16/4/2015
waleed tawfik,benha university 16/4/2015
waleed tawfik,benha university
What is
Does it stimulate reproductive Human release
Is it helpful in IVF
16/4/2015
3 questions ??
kiss
pept
in
waleed tawfik,benha university
What is kisspeptin?
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waleed tawfik,benha university
Kisspeptins are a family of proteins that are essential for fertility.
The first gene member of the family was discovered in 1996 (KISS 1) by a group working in Hershey, Pennsylvania. It is named after the city’s chocolate ‘Kisses’, which are made in Hershey.
Kisspeptin
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waleed tawfik,benha university 16/4/2015
waleed tawfik,benha university
Does kisspeptin stimulate
reproductive hormone release ?
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waleed tawfik,benha university
Kisspeptin is produced from the hypothalamus and causes a chain reaction which leads to production of neurotransmitters from the pituitary gland. The neurotransmitter signals lead to the release of other hormones (luteinising hormone and follicle stimulating hormone) into the blood. These act on testes andovaries to produce the sex hormones testosterone and oestradiol, which cause the physical and emotional changes that are well recognised during puberty.
Kisspeptin
Dhillo et al .,200516/4/2015
waleed tawfik,benha university
LH
GnRH
FSH
Estrogen / testesterone
Kisspeptin/GPR54
hypothalmus
Ant. pitutary
gonads
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waleed tawfik,benha university
Is kisspeptin useful in IVF treatment?
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waleed tawfik,benha university
HCG trigger
FSH stimulation
mature
immature
ovary
Excessive stimulati
on
OHSS
In IVF
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waleed tawfik,benha university
OHSSPleural effusion
Ascites
Renal failure
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waleed tawfik,benha university
Ovarian hyperstimulation syndrome (OHSS) is a major medical problem.
It can be fatal in severe cases and it occurs in women undergoing IVF treatment who are otherwise very healthy.
We really need more effective natural triggers for egg maturation during IVF treatment
OHSS
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waleed tawfik,benha university
GnRh
hypothalamus
kisspeptin
GnRH agonistAnt pitutary
ovary HCGLH receptor
LH FSH
Trigger of oocyte maturation
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waleed tawfik,benha university
Kisspeptin is a novel physiological trigger for inducing oocyte maturation in IVF
therapy
Hypothesis
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waleed tawfik,benha university
rFSHGnRH ant
rFSH
GnRH ant
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waleed tawfik,benha university
53 patients 1.6/3.2 nmol/kgN=(5)
6.4nmol/kgN=(24)
Kisspeptin dosage
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waleed tawfik,benha university
Clinical ease of egg collection 36 hours following kisspeptin-54 injection in patients undergoing IVF therapy
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waleed tawfik,benha university
Circulating reproductive hormones following kisspeptin-54 administration
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waleed tawfik,benha university
Egg maturation following administration of kisspeptin-54
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waleed tawfik,benha university
96%mature oocytes51/53
91% Embryo transfer
49/53
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waleed tawfik,benha university
Response to treatment and progression of pregnancy following IVF treatment.
Clinical pregnancy
12 (22%)
Biochemical pregnancy21 (38) %
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waleed tawfik,benha university 16/4/2015
waleed tawfik,benha university
We are in front of a new revolution in human reproduction understanding.
Kisspeptin can be used as a novel physiological trigger for egg maturation in IVF therapy.
Future studies will assess efficacy in women at high risk of OHSS.
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Conclusion
waleed tawfik,benha university 16/4/2015