June 7th, 2013

Katrin Eichelberg, PhDOffice of Research Training and Special Programs

Division of Extramural Activities, NIAID, NIH

keichelberg@niaid.nih.gov

Welcome to Bethesda!

NIH – 27 Institutes and Centers

Different Missions, Responsibilities and Constituencies

Office of the Director

National Libraryof Medicine

Center for InformationTechnology

Center for Scientific Review

FogartyInternational

Center

National Instituteof Arthritis andMusculoskeletal

and Skin Diseases

National Instituteof Diabetes andDigestive and

Kidney Diseases

National Instituteof Dental andCraniofacial

Research

National Institute onDeafness and Other

CommunicationDisorders

National EyeInstitute

National Heart,Lung, and Blood

Institute

National Instituteon Alcohol Abuseand Alcoholism

National CancerInstitute

National Instituteon Drug Abuse

National Instituteof Environmental Health Sciences

National Instituteof Mental Health

National Instituteof NeurologicalDisorders and

Stroke

National Instituteof Allergy and

Infectious Diseases

National Center on Minority Health and Health Disparities

National Instituteon Aging

National Instituteof Child Health

and HumanDevelopment

National HumanGenome Research

Institute

National Instituteof General

Medical Sciences

National Instituteof Nursing Research

National Centerfor Complementary

and AlternativeMedicine Translational Sciences

National Centerfor Advancing

Translational Sciences

Clinical Center

National Institute of Biomedical Imaging and Bioengineering

no fundingauthority

National Instituteon Minority Health

and HealthDisparities

Where do I find NIH funding opportunities?

You are looking for the information…..

You may feel overwhelmed by the information

Hope to narrow down the information…

To reach your goals!

Information about NIH grantshttp://grants.nih.gov/grants/guide/index.html

Information about NIH Research Traininghttp://grants.nih.gov/training/index.htm

Information about NIAID Funding Opportunitieshttp://www.niaid.nih.gov/researchfunding/ann/Pages/default.aspx

Career Tracks and NIAID/NIH Funding

PhD Career - NIAID

Ph.D. FacultyPosition

AwardTypes

CareerStage

HighSchoolStudent

GraduateStudent

IndependentInvestigator

T32 T32

Diversity Supplements

F32 K22 K99or R00

K99/R00

K01

Postdoc Phase

F31

T32- Institutional training grant (NRSA)-has pre- & postdoc slotsF31- Individual diversity predoc fellowship (NRSA)F32 - Individual postdoc fellowship (NRSA)K01- Mentored Research Scientist Award (epidemiology only)K22- Career Transition AwardK25 -Mentored Qualitative Research Development AwardK99/R00- Pathway to Independence Award

http://www.niaid.nih.gov/researchfunding/traincareer/Pages/careerphd.aspx

K25 RPG

MD Career - NIAID

M.D. FacultyPosition

AwardTypes

CareerStage

MedicalStudent

ClinicalTrainingPhase

Fellowship/Research TrainingPhase

IndependentInvestigator

T35 T32

Diversity Supplements

F32 K24

K01K08K23

T35 - NRSA Short Term Institutional Research Training GrantF30 - Individual Predoctoral MD/PhD and Other Dual Doctoral Degree Fellows (NRSA) T32 - Institutional training grant (NRSA)-has pre-& postdoc slotsF32 - Individual postdoc fellowship (NRSA)K01 - Mentored Research Scientist AwardK08 - Mentored Clinical Scientist Research Career Development AwardK23 - Mentored Patient-Oriented Research Career Development AwardK24 - Mid-Career Investigator Award in Patient-Oriented Research

http://www.niaid.nih.gov/researchfunding/traincareer/pages/careermd.aspx

F30 RPG

NIAID Newsletter Subscriptionhttp://www.niaid.nih.gov/researchfunding/newsletter/pages/subscribe.aspx

Example: Mentored Clinical Scientist Research Career Development Award (Parent K08) FOA

Example: Mentored Clinical Scientist Research Career Development Award (Parent K08)

http://grants.nih.gov/grants/guide/pa-files/PA-11-193.html

Example: Mentored Clinical Scientist Research CDA cont.

Who should I contact?

NIH – 27 Institutes and Centers

Different Missions, Responsibilities and Constituencies

Office of the Director

National Libraryof Medicine

Center for InformationTechnology

Center for Scientific Review

FogartyInternational

Center

National Instituteof Arthritis andMusculoskeletal

and Skin Diseases

National Instituteof Diabetes andDigestive and

Kidney Diseases

National Instituteof Dental andCraniofacial

Research

National Institute onDeafness and Other

CommunicationDisorders

National EyeInstitute

National Heart,Lung, and Blood

Institute

National Instituteon Alcohol Abuseand Alcoholism

National CancerInstitute

National Instituteon Drug Abuse

National Instituteof Environmental Health Sciences

National Instituteof Mental Health

National Instituteof NeurologicalDisorders and

Stroke

National Instituteof Allergy and

Infectious Diseases

National Center on Minority Health and Health Disparities

National Instituteon Aging

National Instituteof Child Health

and HumanDevelopment

National HumanGenome Research

Institute

National Instituteof General

Medical Sciences

National Instituteof Nursing Research

National Centerfor Complementary

and AlternativeMedicine Translational Sciences

National Centerfor Advancing

Translational Sciences

Clinical Center

National Institute of Biomedical Imaging and Bioengineering

no fundingauthority

National Instituteon Minority Health

and HealthDisparities

NIH – The People

Please ask for directions!

The NIH Extramural Team

ReviewStaff

ProgramStaff

GrantsMgmt

Program Staff• Advise you before you submit your appl.

Monitor the review process• Discuss options with you after review• Make funding recommendations• Manage research grants after they are awarded

Grants Management Staff• Monitor grant award, renewals, and closing• Negotiate and coordinate with university

business officials• Ensure compliance with NIH policy• Ensure financial accountability

Review Staff• Assign your application to a review group• Recruit scientists to serve on study

sections• Organize and run peer review meetings• Provide feedback via the summary

statement

What should I asked a Program Officer?

“Dear Dr. Eichelberg, I was hoping to inquire about potentially applying for a K award under the NIAID.”(actual email - May 2013)

• Send a draft of your biosketch and specific aims • (1 page).• Is the proposed research area a good fit for your IC?• Would the K08 be the most suitable grant mechanism for

me?• Specific questions that may be unique to your situation.• Any other advice?

General Principles of Career Development and LRP Awards

Career Development Awards (Ks)

Individual awards Several for MDs (K01, K08, K23, K24) to support

development to become an independent investigators More senior award than a clinical fellowship Some mentored, others are not PhDs (MDs): Mostly K22 and K99/R00: transition awards;

also K01 and K25 Salary for mentored awards: $75-90K + $25-50K research

support; F&A 8% NIAID POC: Katrin Eichelberg (keichelberg@niaid.nih.gov)

Review Criteria for NIH Career Development Awards

Overall Impact. Reviewers should provide their assessment of the likelihood for the candidate to maintain a strong research program, taking into consideration the criteria below in determining the overall impact/priority score. NEW: revised scoring guidance for Ks Candidate Career Development Plan/Career Goals & Objectives Research Plan Mentor(s), Co-mentor(s), Consultant(s), Collaborator(s) Environment and Institutional Commitment to the

Candidate http://grants.nih.gov/grants/peer/critiques/k.htm

NIAID CDA applications are reviewed at the NIAID Scientific Review Program by 4 chartered committees (AIDS, AITC, MID and MID-B)

Physician Scientist: Should I apply for a K08 or K23?

Mentored Clinical Scientist Research Career Development Award (K08) Candidate may propose basic research project

Mentored Patient-Oriented Research Career Development Award (K23) Candidate may only propose Patient-Oriented Research (POR). POR

is defined as research conducted with human subjects (or on material of human origin such as tissues, specimens and cognitive phenomena) for which an investigator directly interacts with human subjects.

K08/23: 3 to 5 yr award Salary: $90,000/yr Research Support: $50,000/yr Review of applications is essentially the same.

K08/K23s: Important NIAID Policies NIAID Eligibility Requirements for (K08/K23) Grant

Applications http://grants.nih.gov/grants/guide/notice-files/NOT-AI-06-002.html “Candidates must have a health professional doctoral degree, such as

the M.D., D.O., D.V.M., or equivalent degree, and a professional license to practice in the United States.”

Career development award applications and NIAID Policy on Support of Clinical Trials http://grants.nih.gov/grants/guide/notice-files/NOT-AI-08-041.html “NIAID will not accept K-series applications proposing to conduct

new, free-standing clinical trials or studies. Any proposed clinical trial or study in a K application must be part of an ongoing clinical trial or program, generally the mentor’s. Career development applicants are encouraged to participate in the planning, design, and implementation of these ongoing clinical trials and studies in order to gain the training and experience necessary to become independent clinical investigators.”

Buried in student loans? LRP to the rescue!

Loan Repayment programs (LRP) NIH wants to encourage outstanding health professionals to pursue careers in

biomedical, behavioral, social, and clinical research. If you commit at least two years to conducting qualified research funded by a domestic nonprofit organization or U.S. federal, state, or local government entity, NIH may repay up to $35,000 of your qualified student loan debt per year. Loan repayment benefits are in addition to the institutional salary you receive for your research.

Clinical Research Pediatric Research Health Disparities Research Contraception and Infertility Research Clinical Research LRP for Individuals from Disadvantaged Backgrounds

General LRP site: http://www.lrp.nih.gov/index.aspx A recorded overview webinar from the LRP Office: http://go.usa.gov/aHx

LRP – Clinical and Pediatric Program Goal: The NIH Loan Repayment Programs supports M.D.s and other

doctoral-level professionals pursue research careers by repaying qualifying educational debt.

Clinical ResearchPatient-oriented research conducted with human subjects, or research on the causes and consequences of disease in human populations involving material of human origin (such as tissue specimens and cognitive phenomena) for which an investigator or colleague directly interacts with human subjects in an outpatient or inpatient setting to clarify a problem in human physiology, pathophysiology or disease, epidemiologic or behavioral studies, outcomes or health services research, or developing new technologies, therapeutic interventions, or clinical trials.

Pediatric ResearchResearch that is directly related to diseases, disorders, and other conditions in children, including pediatric pharmacology.

Life Cycle of a NIH grant applicationUniversity Submits

ApplicationElectronic Submission

National Institutesof Health

Peer Review

Institute(24 with funding authority)

Leaders in the biological and

medical sciences,

education, health care, and

public affairs.

Evaluate Relevance

RecommendAction

TakeAction

Funding cycleFunding cycle

Review of Scientific Merit

Assign to Institute andStudy Section

1946

Tools and Resources

NIH Funded Research - RePORTSearch Many

New Categories

• Over 200 disease categories

• Keywords

• RFA/PA

• Investigator

• Organization

• Funding mechanism

• Recovery Act

• Location

• Study Section

http://projectreporter.nih.gov/reporter.cfmhttp://report.nih.gov/