k~~~~~-...leadtoseeechmia peumonis and noncardigei pulmonary-chitri d--isturbances (ftge,ism...
TRANSCRIPT
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See discussions, stats, and author profiles for this publication at: https://www.researchgate.net/publication/12428995
Occupational exposure to mercury. What is a safe level?
Article in Canadian family physician Médecin de famille canadien · February 1999
Source: PubMed
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Some of the authors of this publication are also working on these related projects:
Drug exposure during lactation View project
Preemptive/Preventive Analgesia - empirical View project
Benjamin Bar-Oz
Hadassah Medical Center
138 PUBLICATIONS 4,009 CITATIONS
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Gideon Koren
Ariel University
2,413 PUBLICATIONS 77,580 CITATIONS
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https://www.researchgate.net/publication/12428995_Occupational_exposure_to_mercury_What_is_a_safe_level?enrichId=rgreq-5274e98e763aaeccbf7f81d366608ab5-XXX&enrichSource=Y292ZXJQYWdlOzEyNDI4OTk1O0FTOjk5MzQ2NzU0MzEwMTUxQDE0MDA2OTc1MjAzNTc%3D&el=1_x_2&_esc=publicationCoverPdfhttps://www.researchgate.net/publication/12428995_Occupational_exposure_to_mercury_What_is_a_safe_level?enrichId=rgreq-5274e98e763aaeccbf7f81d366608ab5-XXX&enrichSource=Y292ZXJQYWdlOzEyNDI4OTk1O0FTOjk5MzQ2NzU0MzEwMTUxQDE0MDA2OTc1MjAzNTc%3D&el=1_x_3&_esc=publicationCoverPdfhttps://www.researchgate.net/project/Drug-exposure-during-lactation?enrichId=rgreq-5274e98e763aaeccbf7f81d366608ab5-XXX&enrichSource=Y292ZXJQYWdlOzEyNDI4OTk1O0FTOjk5MzQ2NzU0MzEwMTUxQDE0MDA2OTc1MjAzNTc%3D&el=1_x_9&_esc=publicationCoverPdfhttps://www.researchgate.net/project/Preemptive-Preventive-Analgesia-empirical?enrichId=rgreq-5274e98e763aaeccbf7f81d366608ab5-XXX&enrichSource=Y292ZXJQYWdlOzEyNDI4OTk1O0FTOjk5MzQ2NzU0MzEwMTUxQDE0MDA2OTc1MjAzNTc%3D&el=1_x_9&_esc=publicationCoverPdfhttps://www.researchgate.net/?enrichId=rgreq-5274e98e763aaeccbf7f81d366608ab5-XXX&enrichSource=Y292ZXJQYWdlOzEyNDI4OTk1O0FTOjk5MzQ2NzU0MzEwMTUxQDE0MDA2OTc1MjAzNTc%3D&el=1_x_1&_esc=publicationCoverPdfhttps://www.researchgate.net/profile/Benjamin-Bar-Oz-2?enrichId=rgreq-5274e98e763aaeccbf7f81d366608ab5-XXX&enrichSource=Y292ZXJQYWdlOzEyNDI4OTk1O0FTOjk5MzQ2NzU0MzEwMTUxQDE0MDA2OTc1MjAzNTc%3D&el=1_x_4&_esc=publicationCoverPdfhttps://www.researchgate.net/profile/Benjamin-Bar-Oz-2?enrichId=rgreq-5274e98e763aaeccbf7f81d366608ab5-XXX&enrichSource=Y292ZXJQYWdlOzEyNDI4OTk1O0FTOjk5MzQ2NzU0MzEwMTUxQDE0MDA2OTc1MjAzNTc%3D&el=1_x_5&_esc=publicationCoverPdfhttps://www.researchgate.net/institution/Hadassah_Medical_Center?enrichId=rgreq-5274e98e763aaeccbf7f81d366608ab5-XXX&enrichSource=Y292ZXJQYWdlOzEyNDI4OTk1O0FTOjk5MzQ2NzU0MzEwMTUxQDE0MDA2OTc1MjAzNTc%3D&el=1_x_6&_esc=publicationCoverPdfhttps://www.researchgate.net/profile/Benjamin-Bar-Oz-2?enrichId=rgreq-5274e98e763aaeccbf7f81d366608ab5-XXX&enrichSource=Y292ZXJQYWdlOzEyNDI4OTk1O0FTOjk5MzQ2NzU0MzEwMTUxQDE0MDA2OTc1MjAzNTc%3D&el=1_x_7&_esc=publicationCoverPdfhttps://www.researchgate.net/profile/Gideon-Koren?enrichId=rgreq-5274e98e763aaeccbf7f81d366608ab5-XXX&enrichSource=Y292ZXJQYWdlOzEyNDI4OTk1O0FTOjk5MzQ2NzU0MzEwMTUxQDE0MDA2OTc1MjAzNTc%3D&el=1_x_4&_esc=publicationCoverPdfhttps://www.researchgate.net/profile/Gideon-Koren?enrichId=rgreq-5274e98e763aaeccbf7f81d366608ab5-XXX&enrichSource=Y292ZXJQYWdlOzEyNDI4OTk1O0FTOjk5MzQ2NzU0MzEwMTUxQDE0MDA2OTc1MjAzNTc%3D&el=1_x_5&_esc=publicationCoverPdfhttps://www.researchgate.net/institution/Ariel-University?enrichId=rgreq-5274e98e763aaeccbf7f81d366608ab5-XXX&enrichSource=Y292ZXJQYWdlOzEyNDI4OTk1O0FTOjk5MzQ2NzU0MzEwMTUxQDE0MDA2OTc1MjAzNTc%3D&el=1_x_6&_esc=publicationCoverPdfhttps://www.researchgate.net/profile/Gideon-Koren?enrichId=rgreq-5274e98e763aaeccbf7f81d366608ab5-XXX&enrichSource=Y292ZXJQYWdlOzEyNDI4OTk1O0FTOjk5MzQ2NzU0MzEwMTUxQDE0MDA2OTc1MjAzNTc%3D&el=1_x_7&_esc=publicationCoverPdfhttps://www.researchgate.net/profile/Benjamin-Bar-Oz-2?enrichId=rgreq-5274e98e763aaeccbf7f81d366608ab5-XXX&enrichSource=Y292ZXJQYWdlOzEyNDI4OTk1O0FTOjk5MzQ2NzU0MzEwMTUxQDE0MDA2OTc1MjAzNTc%3D&el=1_x_10&_esc=publicationCoverPdf
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rs... --b zu-~contaminated...fish,.so
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ile on tox-ic..m.erc
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prepared4by4
Professor~~~~~~~~~~~~~~
Team.~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~........
VOI,45:JANtJARY*JANUERiggg-c-CanadianFamilyPhysician-LeM.decindefamillecanadien 43
. ...........
o you have a question about the safety of dchemicals, radiation;-ok infections 'm w,omen WI
pregimt or breastfeeding? We invite you to subrnitto Dr Gideon Koren by fax at (416) 813-7562; they Nadclressecl in future Motherisk Updates.
Published Motherisk Updates are availab'the College of Family Physicia'ns of Canada w((WWW. m). Some articles are published in 7he MoiNeuskffer also.
k'Ni
......-1,
- FOR PRESCRIBING INFORMATION SEE PAGE 187
-
.e..s.........@s.@e....
severa hundre dayd i fis'h, it"accu-....muae `oconcenitratins tosad
rounigwtrDietr inaei h os imPOr-
tatsource of-n-onoccupatoaP (niromntlepsuet.onmruywith ..fish.~.an-d o-th-er seafoo prouctbigthe. m...aisorcesomecr
in-the de.' niomna xosure: ca als ocura home(rompainte.dM 1wtla pansh at.oti
mercrypgmets orfniids,i
er incertain,-`-":-,-prfessions, such aS:.detsty paint prodution,. and --the-
population~-' and:'for thdi-ose expose.xd at:work.- (includin denissnddetastaff) is metallic (inoranic mercur-y.
Maternal'absorptionan
Ma.t..-ernalI:.por.tals...of entry include~
skin. Tedegre of mternalmer -cuyuptake deensontesefiCheia fomo h ecury anthemrteo abortion ofth-e-r co-and.pon y the rueivle.
MercI''u-rY:can, beasorethog
process1tob fmuch- importance,
Mecrcions:(g2-)aemrradi~-ly absobed truhth itrc.
.Organic.mercur isborb~ed toan evngreaeexettainrncsalts. Most, (80% to: 100%) o hs
tract, but m"u'ch i s. subsequentlysec.'rete ntebl. ic oranic'...mercurials are:volatil and lipid solu-ble,their vapour..re dil 'iffus-es
thro.ug .l'ung aleoli.Teki caals absob t'hese copud, partc
ularly th-rough sores or. wounds'.':M.etalic"mercurHOUi o
appreciably absorbed by the GI.tract
btitimoelpdslublIe thathmecui formn diffssmrThere ore, itiiitibtdmrwidely than~~ ~~~~the ioi form andcne
penetrte* into. the brin,atingconcetain 0tmstoeo e-curic copoud.Eceinsma-
ro-ute,fo methlecr(lination..half-lif7:0dys.
Placentaltransfer~~~~~~~~~~~~~~~~~~~~~~~~~~.......
trt e pae talmmrae n*ho m-u--ch teacUmula'te: wtin
Frmetalic mruy pt .2
ofthe mecr.vpu.nhldbmother rats~~~~~~~~~...was..pre.....sent infeaOts
apparetthtwhlplcnaces
Ontheoter hand,methylecuythemoretoxic form,~~~~~~~~~~~~~~~~~~~~~~~~.pase more.....
Acueihaltio ofhig cn-centationofmtli ercuryvapo-urleadtoseee chmia peumonis
and noncardigei pulmonary-
chitri d--isturbances (ftge,ism
ifuhligfo ofrmntxosr.Imostpeople without roupationa
esaelower.than2hj`2g/dL an"durn evels artowrtalOgLSympomsaresometimes seen wit
Sp/Land .'with oter mercurials
of mer-cury:level in urine.. should
ca e or.de'red-by. Jfamily..-physi-
Prevention, the bes managemeti-straeg in occqOuptonal settings, ~can.
dure,sucas:*aig. apporaevniaini
::--work t:Aeas to-preventoi accu-,
*routinely:sampling: persona and
* monioring erc̀ -ury le-vel 't-hrough'
testn forambient air concentra-tions,which can be :.detecte6d:atlev-
els. as low as 0.0.01 -mg/in3, .an'd* arryn ou.t merCur decnaination procedures in,buildnsbrem~-ttoving carpets;- clening foors--walls, and:.solidssurface s....everal
metaleic ~Mercur sliecnrt-ing Podrachltncopu,~:and a dispesn aget; and applybig.... a pluehne coain to -al
Trsold"lmit vaus(TLV :can
-TA,a short-tr epsre limi
A".TVTA isan 'a'verage ~concen-
:40-ho'ur week to'which workers- canbeepsd wihot adverefecA
TLV-.ST-EL i the' maxim'um. concen-tr-ation acetable duina15mut.period dur-ing a.n:. 8-ho-ur -day.
44 Canadian Family Physician .Le Mtdecin defamille canadien c. VOL 45: JANUARY *JANVIER 1999
.. .. -.-. .. .: .-....
Niiiiiiiiiiiiiii" i -- ... Ili .'
-
CLINICALCHALLINGE*DQPI CLINIQUEItmsould occur no more than..fur
.. i. ............... .... ..~~~~~~~~~~~~~~~~~~~.........:timies dailywith. anhour.b*exposurles. A TlVC... i te rnxallowable, airborne concentration atany time during an 8-our work.t peii.
....~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~... .e ...:.od itshould... no.tbe.exceeded..A
d os t.. l... ie a d ... ......~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~, ...!.:'.. .......' i,i,., :i.:.In Cmanada theMnsty t Laour
adoptedthe United:SatsOccuatinaSafetyand Health n's rec..ornmndaions in settn deforcngwoklc stnars Th _diita
National Institute for OccuptinalSafetya.n.d Health and the American*Conference.o. f.Govrmn Industril..Hyginss These oraitons do:not...........diff.;erentiate between preganit and..non-pregnant pe.ople in ter .recoin-mnendatos Recommended TLV-'TW
.... ...
for me.rc.ury vapour and for inorganic.and nonakyine oraic.mercurialsar.....~~~~~~~~~~~~~~~~~~~~~~~. .............. .shown....in Ta.lUble 1.'.'.InRussia, ThY.C
.....
:..valuesar. mch lower than toe rec-.*o.mmended i...n:Nort A °..mericea:...0.01 rgHg/in3 for mercury vapou.r.(1/n0thof the US recomndations).
..a. n.d 0.OOSrngHg/m3. for alkylO mercury(1/8t of te Urle commendt ion
..... .........
after lu rm e cto.a.urine. concentration of...5.0 pg/L.-(normal value