just-in-time assembly - co-evolution of transcriptional and post-translational cell-cycle regulation...
TRANSCRIPT
![Page 1: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/1.jpg)
Just-in-time assemblyCo-evolution of transcriptional and post-translational
cell-cycle regulation of protein complexes
Lars Juhl JensenEMBL Heidelberg
![Page 2: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/2.jpg)
the cell cycle
![Page 3: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/3.jpg)
grow and divide
![Page 4: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/4.jpg)
one cell
![Page 5: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/5.jpg)
two cells
![Page 6: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/6.jpg)
four phases
![Page 7: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/7.jpg)
G1 phase
![Page 8: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/8.jpg)
growth
![Page 9: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/9.jpg)
S phase
![Page 10: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/10.jpg)
DNA replication
![Page 11: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/11.jpg)
G2 phase
![Page 12: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/12.jpg)
growth
![Page 13: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/13.jpg)
M phase
![Page 14: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/14.jpg)
cell division
![Page 15: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/15.jpg)
![Page 16: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/16.jpg)
regulation
![Page 17: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/17.jpg)
gene expression
![Page 18: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/18.jpg)
phosphorylation
![Page 19: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/19.jpg)
targeted degradation
![Page 20: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/20.jpg)
protein interactions
![Page 21: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/21.jpg)
molecular biology
![Page 22: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/22.jpg)
one gene
![Page 23: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/23.jpg)
one postdoc
![Page 24: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/24.jpg)
many types of data
![Page 25: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/25.jpg)
a single gene
![Page 26: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/26.jpg)
high-throughput biology
![Page 27: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/27.jpg)
one lab
![Page 28: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/28.jpg)
one technology
![Page 29: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/29.jpg)
all the relevant genes
![Page 30: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/30.jpg)
a single type of data
![Page 31: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/31.jpg)
systems biology
![Page 32: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/32.jpg)
many types of data
![Page 33: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/33.jpg)
all the relevant genes
![Page 34: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/34.jpg)
data integration
![Page 35: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/35.jpg)
expression data
![Page 36: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/36.jpg)
cell cultures
![Page 37: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/37.jpg)
![Page 38: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/38.jpg)
synchronization
![Page 39: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/39.jpg)
microarrays
![Page 40: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/40.jpg)
![Page 41: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/41.jpg)
time courses
![Page 42: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/42.jpg)
![Page 43: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/43.jpg)
expression profiles
![Page 44: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/44.jpg)
![Page 45: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/45.jpg)
list of genes
![Page 46: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/46.jpg)
periodically expressed
![Page 47: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/47.jpg)
S. cerevisiae
![Page 48: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/48.jpg)
expression data
![Page 49: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/49.jpg)
Cho et al.
![Page 50: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/50.jpg)
Spellman et al.
![Page 51: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/51.jpg)
computational methods
![Page 52: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/52.jpg)
Zhao et al.
![Page 53: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/53.jpg)
Langmead et al.
![Page 54: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/54.jpg)
Johansson et al.
![Page 55: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/55.jpg)
Wichert et al.
![Page 56: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/56.jpg)
Luan and Li
![Page 57: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/57.jpg)
Lu et al.
![Page 58: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/58.jpg)
Ahdesmäki et al.
![Page 59: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/59.jpg)
Willbrand et al.
![Page 60: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/60.jpg)
Chen
![Page 61: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/61.jpg)
Qiu et al.
![Page 62: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/62.jpg)
Ahnert et al.
![Page 63: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/63.jpg)
Glynn et al.
![Page 64: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/64.jpg)
Andersson et al.
![Page 65: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/65.jpg)
Lu et al.
![Page 66: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/66.jpg)
Xu et al.
![Page 67: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/67.jpg)
Liew et al.
![Page 68: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/68.jpg)
no benchmarking
![Page 69: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/69.jpg)
reanalysis
![Page 70: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/70.jpg)
benchmarking
![Page 71: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/71.jpg)
![Page 72: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/72.jpg)
no progress
![Page 73: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/73.jpg)
no benchmarking
![Page 74: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/74.jpg)
S. pombe
![Page 75: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/75.jpg)
H. sapiens
![Page 76: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/76.jpg)
A. thaliana
![Page 77: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/77.jpg)
reanalysis
![Page 78: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/78.jpg)
benchmarking
![Page 79: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/79.jpg)
list of genes
![Page 80: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/80.jpg)
periodically expressed
![Page 81: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/81.jpg)
four organisms
![Page 82: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/82.jpg)
orthologous groups
![Page 83: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/83.jpg)
sequence similarity
![Page 84: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/84.jpg)
![Page 85: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/85.jpg)
not conserved
![Page 86: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/86.jpg)
others had seen this before
![Page 87: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/87.jpg)
Ota et al.
![Page 88: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/88.jpg)
Rustici et al.
![Page 89: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/89.jpg)
Dyczkowski and Vingron
![Page 90: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/90.jpg)
technical issues
![Page 91: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/91.jpg)
orthology definitions
![Page 92: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/92.jpg)
no reanalysis
![Page 93: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/93.jpg)
different analysis methods
![Page 94: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/94.jpg)
no error estimates
![Page 95: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/95.jpg)
no biological explanation
![Page 96: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/96.jpg)
turn back time …
![Page 97: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/97.jpg)
temporal network
![Page 98: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/98.jpg)
S. cerevisiae cell cycle
![Page 99: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/99.jpg)
![Page 100: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/100.jpg)
dynamic and static subunits
![Page 101: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/101.jpg)
just-in-time assembly
![Page 102: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/102.jpg)
![Page 103: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/103.jpg)
evolutionary flexibility
![Page 104: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/104.jpg)
different organisms
![Page 105: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/105.jpg)
different dynamic subunits
![Page 106: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/106.jpg)
manual curation
![Page 107: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/107.jpg)
protein complexes
![Page 108: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/108.jpg)
![Page 109: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/109.jpg)
![Page 110: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/110.jpg)
![Page 111: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/111.jpg)
different time scales
![Page 112: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/112.jpg)
time warping
![Page 113: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/113.jpg)
![Page 114: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/114.jpg)
same color = same phase
![Page 115: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/115.jpg)
DNA polymerases
![Page 116: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/116.jpg)
![Page 117: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/117.jpg)
dynamic subunits
![Page 118: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/118.jpg)
time of peak expression
![Page 119: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/119.jpg)
time of action
![Page 120: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/120.jpg)
just-in-time assembly
![Page 121: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/121.jpg)
![Page 122: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/122.jpg)
CDK substrates
![Page 123: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/123.jpg)
Übersax et al.
![Page 124: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/124.jpg)
Loog et al.
![Page 125: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/125.jpg)
Phospho.ELM
![Page 126: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/126.jpg)
NetPhosK
![Page 127: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/127.jpg)
correlation
![Page 128: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/128.jpg)
![Page 129: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/129.jpg)
Fisher’s exact test
![Page 130: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/130.jpg)
![Page 131: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/131.jpg)
cell cycle vs. non-cell cycle
![Page 132: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/132.jpg)
correlated changes
![Page 133: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/133.jpg)
![Page 134: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/134.jpg)
Fisher’s exact test
![Page 135: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/135.jpg)
![Page 136: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/136.jpg)
co-evolution
![Page 137: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/137.jpg)
transcriptional regulation
![Page 138: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/138.jpg)
phosphorylation
![Page 139: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/139.jpg)
targeted degradation
![Page 140: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/140.jpg)
just-in-time assembly
![Page 141: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/141.jpg)
![Page 142: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/142.jpg)
Acknowledgments
Thomas Skøt JensenUlrik de Lichtenberg
Søren BrunakPeer Bork
![Page 143: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/143.jpg)
Thank you!
![Page 144: Just-in-time assembly - Co-evolution of transcriptional and post-translational cell-cycle regulation of protein complexes](https://reader036.vdocuments.us/reader036/viewer/2022070519/58ee08691a28ab5a678b46b3/html5/thumbnails/144.jpg)
Questions?