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journal.pone.0069646.s004

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Table S1. Antibiotic susceptibility status for fluoroquinolone-resistant clinical isolates. Antibiotics Resisted Clinical Isolate Aminoglycosi de Nitrofuran toin Sulfadrug Monobacta m Penicil lin Cominbinati on Penicillin Cephalospor in ELZ4073 - - - - - - - ELZ4006 - - Trimethoprim- sulfamethoxazo le - - - - ELZ4062 - - Trimethoprim- sulfamethoxazo le - - - - ELZ4368 - - Trimethoprim- sulfamethoxazo le - Ampicil lin - - ELZ4277 - - Trimethoprim- sulfamethoxazo le - Ampicil lin - - ELZ4033 Kanamycin - Trimethoprim- sulfamethoxazo le - Ampicil lin - - ELZ4234 - Nitrofuran toin - - Ampicil lin - Cefazolin Cefepime Cefotetan Cefoxitin Ceftazidime ELZ4137 Gentamicin Tobramycin Nitrofuran toin - - Amoxicillin -clavulanic acid Cefazolin Cefotetan ELZ4251 Gentamicin Tobramycin - Trimethoprim- sulfamethoxazo - Ampicil lin Cefazolin Cefotaxime

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Table S1. Antibiotic susceptibility status for fluoroquinolone-resistant clinical isolates.Antibiotics Resisted

Clinical IsolateAminoglycosideNitrofurantoinSulfadrugMonobactamPenicillinCominbination PenicillinCephalosporin

ELZ4073-------

ELZ4006--Trimethoprim-sulfamethoxazole----

ELZ4062--Trimethoprim-sulfamethoxazole----

ELZ4368--Trimethoprim-sulfamethoxazole-Ampicillin--

ELZ4277--Trimethoprim-sulfamethoxazole-Ampicillin--

ELZ4033Kanamycin-Trimethoprim-sulfamethoxazole-Ampicillin--

ELZ4234-Nitrofurantoin--Ampicillin-Cefazolin Cefepime Cefotetan Cefoxitin Ceftazidime

ELZ4137Gentamicin TobramycinNitrofurantoin--Amoxicillin-clavulanic acidCefazolin Cefotetan

ELZ4251Gentamicin Tobramycin-Trimethoprim-sulfamethoxazole-AmpicillinCefazolin Cefotaxime Ceftriaxone

ELZ4152TobramycinNitrofurantoinTrimethoprim-sulfamethoxazole--Amoxicillin-clavulanic acid Ticarcillin-clavulanic acid-

ELZ4054Gentamicin-Trimethoprim-sulfamethoxazoleAztreonamAmpicillin-Cefazolin Cefotaxime Cefoxitin Ceftazidime Ceftriaxone

ELZ4051Gentamicin Tobramycin-Trimethoprim-sulfamethoxazole-AmpicillinAmoxicillin-clavulanic acidCefazolin Cefepime Cefotaxime Cefotetan Cefoxitin Ceftriaxone

ELZ4011Gentamicin Tobramycin-Trimethoprim-sulfamethoxazole-AmpicillinTicarcillin-clavulanic acidCefazolin Cefoxitin

ELZ4083-NitrofurantoinTrimethoprim-sulfamethoxazole-AmpicillinAmoxicillin-clavulanic acid Ticarcillin-clavulanic acidCefazolin Cefotaxime Cefotetan Cefoxitin Ceftazidime Ceftriaxone

ELZ4067--Trimethoprim-sulfamethoxazoleAztreonamAmpicillinTicarcillin-clavulanic acidCefazolin Cefotetan Cefoxitin Ceftazidime Ceftriaxone

ELZ4238Amikacin Gentamicin Tobramycin-Trimethoprim-sulfamethoxazoleAztreonamAmpicillin-Cefazolin Cefotaxime Ceftazidime

ELZ4223Gentamicin Tobramycin-Trimethoprim-sulfamethoxazole-AmpicillinAmoxicillin-clavulanic acid Ticarcillin-clavulanic acid Pipercillin-tazobactamCefazolin Cefoxitin

ELZ4004Gentamicin Tobramycin-Trimethoprim-sulfamethoxazoleAztreonamAmpicillinTicarcillin-clavulanic acid Pipercillin-tazobactamCefazolin Cefepime Cefotaxime Cefoxitin Ceftazidime Ceftriaxone

ELZ4091Gentamicin Tobramycin-Trimethoprim-sulfamethoxazoleAztreonamAmpicillinTicarcillin-clavulanic acid Pipercillin-tazobactamCefazolin Cefepime Cefotaxime Cefoxitin Ceftazidime Ceftriaxone

ELZ4220Gentamicin TobramycinNitrofurantoinTrimethoprim-sulfamethoxazole-AmpicillinAmoxicillin-clavulanic acid Ticarcillin-clavulanic acidCefazolin Cefotetan Cefoxitin Cefotaxime

ELZ4288Gentamicin Tobramycin-Trimethoprim-sulfamethoxazoleAztreonamAmpicillinAmoxicillin-clavulanic acid Ticarcillin-clavulanic acidCefazolin Cefotaxime Cefotetan Cefoxitin Ceftazidime Ceftriaxone

ELZ4240Amikacin Gentamicin TobramycinNitrofurantoinTrimethoprim-sulfamethoxazole-AmpicillinAmoxicillin-clavulanic acid Ticarcillin-clavulanic acid Pipercillin-tazobactamCefazolin Cefoxitin

ELZ4000Gentamicin Tobramycin-Trimethoprim-sulfamethoxazoleAztreonamAmpicillinPipercillin-tazobactamCefazolin Cefotaxime Cefoxitin Ceftazidime Ceftriaxone

ELZ4013Gentamicin TobramycinNitrofurantoinTrimethoprim-sulfamethoxazoleAztreonamAmpicillinTicarcillin-clavulanicCefazolin Cefepime Cefotaxime Cefotetan Cefoxitin Ceftazidime Ceftriaxone

ELZ4268TobramycinNitrofurantoinTrimethoprim-sulfamethoxazoleAztreonamAmpicillinAmoxicillin-clavulanic acid Ticarcillin-clavulanic acid Pipercillin-tazobactamCefazolin Cefepime Cefotamine Cefoxitin Ceftazidime Ceftriaxone

ELZ4486*Amikacin Gentamicin TobramycinNitrofurantoinTrimethoprim-sulfamethoxazole-AmpicillinAmoxicillin-clavulanic acid Ticarcillin-clavulanic acid Pipercillin-tazobactamCefazolin Cefepime Cefotaxime Cefotetan Ceftriaxone

ELZ4273TobramycinNitrofurantoinTrimethoprim-sulfamethoxazoleAztreonamAmpicillinAmoxicillin-clavulanic acid Ticarcillin-clavulanic acid Pipercillin-tazobactamCefazolin Cefepime Cefotaxime Cefotetan Cefoxitin Ceftazidime Ceftriaxone

* Resistant to Imipenem


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