Jonathan ImsBME 281 Sec. 1

1964, Folkman demonstrated a silicon rubber pill for low molecular weight drugs.

1970s, Langer expanded on Folkman ◦ Polymers that could carry macromolecules

Mid 1990’s the idea of a drug releasing microchip by J. Santini Jr. ◦ J. Santini Jr. went to MIT

Mechanical Micro Pumps◦ Need a physical actuator

Non-mechanical Micro Pumps◦ Converts some form of energy into kinetic momentum

Key components High Flow Rate Low Voltage (between 5 -12V) Reliability of the System Bio-compatibility Frequency

The width and length of each chip varies but the depth of the chip remains between (0.5mm to 1mm)

8 reservoirs can be found in an area of 1.77mm by 1.44mm

The reservoirs can hold a total of 200nL

Patients with Chronic Disease◦ Diabetes◦ Epilepsy◦ Osteoporosis◦ etc.

It is not meant to replace prescription pills for common illnesses such as the flu.

Surgery Unwanted Side Effects

◦ Heat◦ Pressure◦ pH◦ Bio-compatibilty

Reservoir size

Increase the efficiency of drug delivery Self-drug releasing chips Different types of drug release Better bio-materials