1

The European Commission’s scienceand knowledge service

Joint Research Centre

2

The modern safety assessment toolbox

Organ-on-Chip

In vitro

biokinetics

Legacy data

'omics

High Throughput Screening

In chemico In silico

Mechanistic thinking !

Clinicaldata

3

4

Mechanistic data versus information requirements

5

Sub-Committee of

Experts on the GHS

GHS classification criteria

for non-animal methods

Netherlands / U.K. (leading IWG)

6

Ongoing initiatives & NGTX carcinogenicity

Predicting carcinogenic potential of agrochemicals with info from repeated dose

toxicity studies & MoA

Integrated approach to testing and assessment

(IATA) of NGTX carcinogens

EURL ECVAM DB of Ames negative chemicals

COMING SOON!

JRC co-lead

7

Cross-endpoint evaluation

Madia et. al. Env. Int., 2019

Work in progress

Addressing the challenges of cancer & chemicals in the environment

8

Fostering collaboration across different initiatives & cross-sector fertilisation

ICH, OECD, EPAA, ReCAAP, HESI e-STAR, Leadscope, …..& many others

9

Evolution vs revolution

Approaches that accommodate current regulatory framework

10

Thank youraffaella.corvi@ec.europa.eu

https://ec.europa.eu/jrc/en/eurl/ecvam

@EU_ScienceHub #ECVAM

News from EURL ECVAM