www.innovationwell.net

Critical Paths inDrug Development

Decision Support for R&D

Metabolomics

Biomarkers

Join industry experts to find outwhat’s new in these fields...

Community of PracticeIntegrating Knowledge in theLife Science Product Life Cycle

Seminars and panel discussionsin the mornings

Associated workshops in theafternoons to explore the topicsin greater depth

Knowledge Café, Poster Session andnetworking events in the evenings

...with a format designed to maximizeInterAction...

...and also attend relateddrug discovery sessions...

Structure-based Drug Design

Screening & Docking

Discovery Tools & Modeling

Medicinal Chemistry

Predictive Toxicology

Further details on http://echeminfo.com

For further information, abstracts andspeaker bios, see

Structure-Based Drug DesignTargeting Infectious DiseaseErin Duffy (Rib-X)

www.innovationwell.netDoug

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Join us on Tuesday evening for anopen session on Knowledge Manage-ment in R&D including open seminarsand demonstrations of ElectronicLaboratory Notebooks, followed bya Knowledge Café and reception!

Special Open Session onElectronic Laboratory Notebooks

The Role of Systems Biology and KnowledgeManagement in Advancing Toxicology Knowledgein Big Pharma, Peter Henstock (Pfizer)

Advanced Technology in Support ofAnalytics in the Life SciencesCraig Liddell (Realtime Science)

Case Studies in Using Interactive VisualAnalytics to Accelerate Drug DevelopmentDavid Mosenkis (Spotfire)

Searching for Answers in Drug Development:The Game of Twenty QuestionsDennis Underwood (Praxeon)

Management Reporting of Clinical TrialPrograms, Portfolios, and Studies:Managing Risks / Managing ProjectsJoel Hoffman (Insightful)

Associated afternoon workshops...

Joel Hoffman (Insightful)Applying Roadmap processes to the Clinical Trials Project Process

Joseph Bitran (Enterprizer) Innovation Management in R&D – an Enterprizer Briefing and Case Study

David Mosenkis (Spotfire)Using Interactive Visual Analytics to Accelerate Drug Development

Electronic Laboratory Notebook Workshops

Why the “Top-Down Approach” to Knowledge and ContentManagement has failed the United Sates Intelligence Com-munity – Implications for Healthcare ResearchDuane Shugars (Concentia Digital)

Knowledge Management forTranslational ResearchJian Wang (Biofortis)

Applying Knowledge AssessmentTechniques to improving Productivityin Life Science ResearchJeff Spitzner (Rescentris)

What a Quality Assurance Program cando to Facilitate Clinical Research andDevelopment ProcessDelia Y. Wolf (Harvard Medical School)

Building an Informatics Infrastructure forTranslational ResearchJonathan Sheldon (InforSense)

A Framework for Research InformaticsPeter Gates (Johnson & Johnson PR&D)

Utilising Knowledge Management to Increase R&D Productivity along Critical PathsChair: Michael Liebman (Windber Research Institute)

Associated afternoon workshops...

Delia Y. Wolf (Harvard Medical School)Carrying out an Onsite Audit and Self-assessment inClinical Trial Management

Barry Hardy (Douglas Connect) & Jeff Spitzner (Rescentris)Knowledge Assessment in R&D - Impact on ProjectManagement & Research Productivity

Decision Support for Research & DevelopmentChair: TBA

Associated late afternoon workshops ...

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ctApplication of Metabolomics to Drug Discovery & DevelopmentChair: George G. Harrigan (Monsanto)

FDA's Critical Path Initiative:Opportunities for MetabolomicsRick Beger (NCTR, FDA)

Uses and Abuses ofMetabonomics inPharmaceutical PreclinicalSafety AssessmentDon Robertson (Pfizer)

Analysis of Metabolic Pro-filing Data - Combining theStrengths of NMR and MSNick Haan (BlueGnome)

A Pharma Perspective on Metabolomics- the Opportunities and RealitiesSusan Connor (GlaxoSmithKline)

Tracer Substrate-based Metabolomics and the2005 Nobel Prize award in Physiology & MedicineLaszlo Boros (SIDMAP)

Studies of Drug-Induced Liver Injury using Comprehensive2D Gas Chromatography with Time-of-Flight DetectionEric Nemec (Leco Corporation)

Serum Markers of Caloric RestrictionBruce Kristal (Cornell University)

Standards in Reporting InitiativeOliver Fiehn (UC Davis Genome Center)

Identification of Novel, MinorLipids in Total Lipid Extracts ofEschericia Coli using ElectrosprayIonization Mass SpectrometryTeresa Garret (Duke University)

Andrew N. Lane (JG Brown Cancer Center, U. Louisville)NMR-based Positional Isotopomer Analysis in Metabolomics

S. Stanley Young (National Institute of Statistical Sciences)Linking Metabolic Profiles to Biological Outcome

Gregory Banik (Bio-RAD)Understanding Metabolomics Mixtures with Principal Components Analysis

www.innovationwell.net

Application of Metabolomics toBiomarker and Off-Target SideEffect Identification in MarketedDrugs and New Chemical EntitiesAlvin Berger (Metabolon)

Toward Diagnosis of Diabetesby NMR-based MetabolomicsGregory Banik (Bio-RAD)

Don’t miss this evening’sPoster Session

with drinks & barbecue

Biomarker Discovery & Applications in Drug DevelopmentChair:TBA

Harnessing the Power of Systems Biology – DeliveringMechanism-of-Action and Biomarkers in Drug DevelopmentKeith Elliston (Genstruct)

Many Layers of Biomarker Roles in Tumor ImmunotherapyZentam Tsuchihashi (Bristol-MyersSquibb)

Multivariate Biomarkers DiscoveryDarius Dziuda (Central Connecticut StateUniversity)

Application of Proteomics toBiomarker DiscoveryMichael Jones (Novartis)

Perspectives for Multi-Epitope Ligand Kartography(MELK) for Detection of Diagnostic and TherapeuticBiomarkers in Skin Diseases, Allergology and BeyondBernd Bonnekoh, (Otto-von-Guericke-University)

Ansgar J. Pommer (SkinSysTec), Analyzing in-situ Proteomics by Multi Epitope Li-gand Kartography (MELK) for Detection of Diagnostic and Therapeutic Biomarkers

Associated afternoon workshop...

5 ways to register...

Online at innovationwell.net(Ticket Office is only visible after login)

Email innovationwell at douglasconnect.com

Phone Nicki Douglas on +41 61 851 04 61

Fax +44 870 112 38 44 (eFax)

Post Douglas Connect, Baermeggenweg 14 4314 Zeiningen, Switzerland

Please selectPlease register me for InnovationWell InterAction Meetingat Bryn Mawr College, PA, October 16-19, 2006Registration fee $1300

Please register me for InnovationWell InterAction Meetingat Bryn Mawr College, PA, October 16-19 at theAcademic Registration fee of $650

All registration payments must be received in advanceof the Meeting.Payments can be made by bank transfer, cheque orcredit card: Amex, MasterCard, Visa

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Register now for InnovationWell’s InterAction Meeting onInnovation in Life Science & Healthcare Research & Product Development

BlueGnome is a leader in the field of analysis oflife sciences data having been founded in 2001 byleading researchers at the University of Cambridge.Initially used to improve automation and interpreta-tion of microarray data, the underlying technologyhas now been extended in close collaboration withmajor pharmaceutical companies to target NMR andMS platforms.

Today BlueGnome comprises a scientific cocktail ofworld class mathematicians, engineers, chemists andbiologists, and is rapidly growing on the basis of itspowerful technology, professional and informedcustomer service, and reliable on-time delivery.

In summer 2006 BlueGnome launched its BiomarkersConsortium to set the commercial standard for datafusion, processing and analysis.

Since the introduction of the first rapid carbon determinator in1936, industries around the world have trusted LECO Corporation todeliver technologically advanced products and solutions fororganic and inorganic analysis.Today LECO is recognized globally as a leader in the development ofhigh-quality analytical instrumentation, mass spectrometers andchromatographs, metallography equipment, and consumables.

www.leco.com

Our special thanks go toCollene Wells and Dennis McHenryfor the permission to use theirphotographs of Bryn Mawr Campusin this brochure