john douglas mann, m.d. - unc health care · john douglas mann, m ... university of north carolina...

CURRICULUM VITAE (May 20, 2013)

John Douglas Mann, M.D.

Professor of Neurology Department of Neurology University of North Carolina School of Medicine

EDUCATION High School: George E. Thompson High School

St. Charles, Illinois, 1957 - 1961

College: Amherst College Amherst, Massachusetts, 1961 - 1965

Degree: B.A., cum laude

Medical School: Cornell University Medical College New York, New York, 1965 - 1969 Degree: M.D.

TRAINING Internship: University of Virginia Hospital Charlottesville, Virginia, 1969 - 1970, Medicine - Pediatrics

Residency: Neurology: University of Virginia Hospital, 1970 - 1973 Chief Resident in Neurology 1972 - 1973, Thomas R. Johns, MD, Professor and Chairman

Post-Doctoral Fellowship: Research Associate in Neurochemistry University of Virginia, July, 1973 - June, 1976 Norman H. Bass, MD, Research Advisor and Mentor CERTIFICATION / LICENSURE Diplomate of the National Board of Medical Examiners, July, 1970 Certificate of the Virginia State Board of Medicine, 1972 - 1995, License Number 0101022656 Diplomate of the American Board of Psychiatry and Neurology, June, 1976, 06066 Member, 15305 Diploma Certificate of the North Carolina Board of Medicine, August, 1976 to the present, License Number 21075

John Douglas Mann, M.D. Curriculum Vitae

Practitioner, Neurolinguistic Programming, Alan Konell (Chapel Hill, NC) Trainer, 1997. Master Practitioner, Neurolinguistic Programming, Alan Konell(Chapel Hill, NC) Trainer, 1998. ACADEMIC POSITIONS Instructor and Research Fellow in Neurochemistry, Department of Neurology, University of Virginia Hospital, July, 1974 - June, 1976, Norman H. Bass, MD Research Advisor and Sponsor Assistant Professor, Department of Neurology and Internal Medicine, University of North Carolina, Chapel Hill, August, 1976 - June, 1981, James N. Hayward, MD, Professor and Chairman, Neurology Department of Neurology Associate Professor, Department of Neurology and Internal Medicine, University of North Carolina, Chapel Hill, July, 1981 to July 1993, James N. Hayward, MD, Professor and Chairman, Neurology Department of Neurology Professor, Department of Neurology and Internal Medicine, University of North Carolina, Chapel Hill, July, 1993 to the present Dr. William Powers, Current Professor and Chairman Department of Neurology AWARDS AND HONORS Prior Awards And Honors

American Field Service Representative to Germany, Student Exchange, 1960 Cum Laude, Amherst College, Amherst, Massachusetts, 1965 Chief Resident in Neurology, University of Virginia Hospital, 1972 - 1973 Special Fellowship, National Institutes of Neurological Diseases and Stroke, Research in


Neurochemistry (1 F22 NS02159), Sponsor: Norman H. Bass, July, 1974 - June, 1976 Teacher Investigator Award, NINCDS (5 K07 NS00244), August, 1976 - June, 1981 UNC Medical School Pearls Day Participant, 1978, 1979,

1983 and 1986 Nominee, Distinguished Faculty Teaching Award,

University of North Carolina School of Medicine, May, 1991 Nominee, CCB and Kaiser-Permanente Excellence in Teaching Award,

Whitehead Medical Society, University of North Carolina School of Medicine, July, 1993.

Nominee, Battle Clinical Sciences Distinguished Excellence Award, Whitehead Medical Society, University of North Carolina School of Medicine, July, 1994.

Deans Excellence in Teaching Award, UNC School of Medicine, 1999. Certificate of Appreciation for Outstanding Team Commitment, UNC

Health Care System, February, 2002. Sabbatical Program, University of North Carolina: Half-time leave for one year for scholarly development. July 2001 – June 2002. Neurology Residents Yearly Award for Outstanding Faculty Teaching – 2003.

American Academy of Neurology, A.B. Baker Section on Neurological Education, Teacher Recognition Award – 2004.

UNC School of Medicine Academy of Educators Award, Senior Associate Fellow, 2007.

Best Doctors in America Award, 2008 - 2012 PROFESSIONAL ASSOCIATIONS American Academy of Neurology, Active Member Since 1975 (#06066) American Medical Association American Pain Society North Carolina Medical Society North Carolina Neurological Society Consortium of Academic Health Centers for Integrative Medicine. COMMITTEES, APPOINTMENTS and PROFESSIONAL ACTIVITIES:

UNC SCHOOL OF MEDICNE AND HOSPITALS (Continuous from dates shown or for periods indicated):

Appointments:

Director, Neurology Outpatient Services, 1978 - 2009 Director, Neuroscience and Special Senses Section, Second Year Medical

School Curriculum, 2000 – 2008 Director Integrative Medicine, University Headache Clinic, 1999 – 2008.

Director of Clinical Services, Program on Integrative Medicine, 2001 – 2010

Medical Director, Multidisciplinary Pain Management Program, UNC School of Medicine and UNC Hospitals, 1984 to 2004


Director, Neurological Education, Dept. of Neurology, 1977 – 1987, 1996-2005 COMMITTEES AND ADVISORY ACTIVITIES

Medical School

AHEC Medical Education Advisory Committee 2003 – 2010 Second Year Course Directors Committee, 2000 – 2009 Third and Fourth Year Course Directors Committee, 1999 - 2003.

Class Advisor for Students Interested in Careers in Neurology, 1980 – present

UNC School of Medicine Space Committee, 2004 – 2009. Program on Integrative Medicine Advisory Committee, 1999 - present UNC Hosptials

Clinic Directors Committee, 2004 - 2008 Medical Information Management and Clinical Documentation

Committee, 1993 – 2012 UNC IRB Chairman, Biomedical Section B, UNC, 2008-present Post-Tenure Review Committee, 2009- present

Advisory Board, The Visiting Clinician Program at UNC, 2000 - 2004

National/International UNC Representative to the Steering Committee of the Consortium of

Academic Health Centers for Integrative Medicine, 2005 - present

Previous Advisory Board, Program on Aging, 1988-1992 Ambulatory Care Council, 1985 - 1990 Ambulatory Care Physician Directors Forum, 1995 - 1997 Ambulatory Care Selective Committee, 1989-1991

Chairman, Medical School Fourth Year Electives Committee, 1997- 2002 Clinical Practice Committee, 1986-1988 Committee on the Changes in the Clinical Curriculum, 1987-1990 Course Director: Neurological Physical Diagnosis, 1980 - 1997 Educational Policy Committee, 1978 Fetal Tissue Research Task Force, 1993-1994 Dean’s Five Year Review Committee, Chair – Anesthesiology, 2004 Graduate Medical Education Committee, 1981 - 1991 Health Sciences Library Committee, 1978 - 1980


Medical Records and Quality Assurance Committee, 1976 - 81 Medical Records Committee, 1981-1993

Medical School Electives Committee, 1976 - 2002 Neurosciences Visiting Lecturer Committee, 1978 -1981

Pain Quality Assurance Committee - UNC Hospitals, 1999-2002 Task Force on Teaching in the Ambulatory Care Setting, 1989-1991

OTHER RELEVANT EDUCATION, SKILLS AND EXPERIENCE Neurolinguistic Programming, Practitioner Training, 1996 -1997, Durham, NC.

Alan Konell, MSW Trainer

Neurolinguistic Programming, Master Practitioner Training, 1997-1998, Durham, NC. Alan Konell, MSW Trainer

American Society of Clinical Hypnosis, Accreditation Workshop Level I (20 hours),

Holly Forester-Miller, PhD, Course Director, Durham, NC, June 2000.

American Society of Clinical Hypnosis, Accreditation Workshop Level II (20 hours), Holly Forester-Miller, PhD, Course Director, Durham, NC, June 2001.

American Society of Clinical Hypnosis, Precepting Accreditation,

Holly Forester-Miller, PhD, (Preceptor), Durham, NC, December 2001- 2005. Professional Training in Mindfulness-based Stress Reduction. Mentor

Jon Kabat-Zinn, Omega Institute, Rhinebeck, NY, June 2001. Buddhist Sutrayana and Vajrayana Seminary Programs 2003 - 2008.

Karme-Choling Shambhala Buddhist Center, Vermont, 2002; Rocky Mountain Shambhala Buddhist Center, Colorado, 2005

RESPONSIBILITIES RELATED TO COMPLEMENTARY AND ALTERNATIVE

MEDICINE: 2002-2013 Clinical Services

Co-Director, Mindfulness-Based Stress and Pain Management Program, April 2000 - present.

Director, Program on Integrative Medicine Consult Service, UNC School of Medicine, Chapel Hill NC. September 1999 - present. Director of Clinical Services, UNC Program on Integrative Medicine, 2002 - present.

COURSE DEVELOPMENT: ORGANIZING, DIRECTING, PARTICIPATING


PMED 203: "Introduction to Integrative Medicine." UNC at Chapel Hill, School of Medicine. Spring 2000 - 2002.

PMED 242: Medical School Year Two. “Neurosciences.” 1999 – 2008. Co-Director, 104 hour course with Psychiatry, Neuropathology, Opthalmology,

Neuropharmacology, Neuropathology, Neurosurgery and Otolaryngology.

PMED 250: "Principles and Practices of Alternative and Complementary Medicine." UNC at Chapel Hill, School of Medicine. Cross-listed in Public Health, Nursing, Dentistry and Pharmacy. A weekly 3 hour class that features seminar type discussion mixed with lectures by community practitioners of integrative medicine. 1999 - present.

Faculty Advisor for Medical Students.

Medical Students Interested in Neurology as a Career, 1997 – 2010. Medical Student Holistic Medicine Interest Group ("Integrate!"), UNC at Chapel Hill, School of Medicine, 2000 - 2008.

Conference Development (Planning and Participation)

The 5th UNC Integrative Medicine Conference: Improving Outcomes Through Integrative Practice. UNC - Chapel Hill. Jointly sponsored by UNC Schools of Medicine and Nursing. Friday Center, UNC Campus. March 18-19, 2005. Planning and participating as speaker, moderator and panel member.

The 4th UNC Conference on Integrating Complementary and Alternative

Medicine in Clinical Practice: Expanding Choices in Healing and Health Care. UNC - Chapel Hill. Jointly sponsored by UNC Schools of Medicine, Nursing, Pharmacy and Institute of Nutrition. Friday Center, UNC Campus. March 14-15, 2003. Planning and participating as speaker, moderator and panel member.

Conference Development Prior to 2002

The "3rd Annual Clinical Relevance of medicinal Herbs and Nutritional Supplements in the Management of Major Medical Problems," UNC - Chapel Hill. Jointly sponsored by UNC Schools of Medicine, Nursing, Pharmacy and Public Health. Friday Center, UNC Campus. September 21-22, 2001. Co-Director and Moderator.

"Complementary and Alternative Medicine in Cancer: Real Change for the

Real World" - 5th Annual Integrating Mind, Body and Spirit in Medical Practice. Jointly sponsored by UNC Health Care (Program on Integrative Medicine), Duke University Medical School (Center for Integrative Medicine),


and Duke Comprehensive Cancer Center, Friday Center, UNC campus. November 18, 2000. Co-Organizer / Speaker.

"UNC-Community Forum: Integrating Alternative and Conventional Health

Care: 21st Century Challenges and Solutions." Hill Alumni Center, UNC Campus. October 20, 2000. Co-Organizer / Speaker.

"2nd Annual Clinical Relevance of Medicinal Herbs and Nutritional

Supplements in the Management of Major Medical Problems," UNC at Chapel Hill. Jointly sponsored by UNC Schools of Medicine, Nursing and Pharmacy. Friday Center, UNC campus. March 24-26, 2000. Participant/Speaker.

OTHER ACTIVITIES Prior Institutional Activities Curriculum in Neurobiology, 1978 – 2003 Toxicology Curriculum, 1978 - 1984 Clinical Investigator, Multi-Center EC-IC By-Pass Protocol, 1979 - 1985

Dissertation Committee Member for Doctoral Candidate

Estephan Moana. School of Dentistry, Oral Biology PhD Program, University of North Carolina at Chapel Hill, 27599 Thesis Advisor 2011 – 2013. Degree: PhD. Awarded

Thesis: “Investigation of augmented sensory processing mechanisms in fibromyalgia.”

Johna Register, Department of Exercise and Sports Science, University of North Carolina at Chapel Hill, 2006-2007.

Thesis Advisor 2005 – 2007. Degree MA, awarded 2006. Thesis: “Effects of headache on clinical measures of neuropsychological function and postural stability.“

Remy Coeytaux MD, School of Public Health, University of North

Carolina at Chapel Hill, 2001 – 2004. Thesis Advisor, 2001 – 2004. Degree: PhD, awarded 2004. Thesis: “Acupuncture as an adjunct to medical care for chronic daily headache.”

Daniele Ouellet, School of Pharmacy, University of North Carolina at

Chapel Hill, Gary M. Pollack, PhD Thesis Advisor, 1991-1994. Degree PhD

Thesis: "Kinetics of tolerance to morphine analgesia."


Eileen Ahern, Biomedical Engineering Curriculum, University of North Carolina at Chapel Hill, Richard N. Johnson, ScD, Director: Thesis Advisor, 1987-88. Degree PhD Thesis: "Computer aided design and evaluation of shunting devices for the treatment of hydrocephalus."

Faculty Advisor for Masters Program Maya Kommineni, School of Public Health, University of North Carolina Chapel Hill,

Thesis Advisor 2001-2002. Degree MPH Thesis: “Daily documentation of diet, exercise and sleep in

patients with migraine: Feasibility and effectiveness.”

Headache / Pain Fellowship Mentor, 2002 – 2009 UNC Dept of Neurology David Watson 2003-2004 Heather Adkins 2006-2007 Mathew Engelbrecht 2006-2007 Cori Millen 2008-2009

Headache / Pain Fellowship Mentor Prior to 2002 – UNC Dept Neurology Alan G. Finkel, MD 1989-1990 William P. Cheshire, MD 1991-1992 Abigail C. Anderson, MD 1995-1996 Kevin Kahn, MD 1996-1998 Pavan Yermesetty, MD 2000-2001 T-32 NIH/NCCAM Research Fellowship Program Eric Garland, PhD 2008-2010 Gary Asher, MD 2008-2010 Karen Leniek, MD 2008-2010 Christopher Ramsden, MD 2008-2010 Mairead Moloney, PhD 2009-2012 Sunyata Smith, PhD 2009-2012 Daisy Zamora, PhD 2010-2013 Kim Faurot, Pre-Doctoral 2011-2013 Karen Bluth, PhD 2012- present Laura Kiken, PhD 2012- present Johann Hsu, MD 2012-present PROFESSIONAL SERVICE Professional Journals - Active


Journal Associate Editorship 2002 - 2008 Complementary Health Practice Review, 2004 – 2010 Journal Editorial Boards 2002 -2008

Explore: The Journal of Science and Healing, 2004 – present Alternative Therapies in Health and Medicine, 2001 – present Reviewer Pain Neurology Experimental Neurology Pharmacology and Experimental Therapeutics Pharmacology, Biochemistry and Behavior Annals of Pharmacotherapy Neurology Board Examiner American Board of Neurology and Psychiatry 1978 - 1986 NIH / NCCAM STUDY SECTION PARTICIPATION 2005 – 2009 Title: Training and Education Identifier: 2009/01 ZAT1 LD (28) Date: October 28 – 31, 2008 Title: Clinical Research Identifier: 2007/01 ZAT JH (18) Date: October 30 – 31, 2006 Title: Clinical Science Identifier: 2006/05 ZAT1 JH (15) Date: Feb13 – 14, 2006 Title: Training and Education Identifier: 2006/05 ZAT1 JH (07) Date: March 14 – March 15, 2006 Substitute Chair Title: Clinical Science Identifier: 2006/05 ZAT1 LD (04) (1) Date: July 8 – 9, 2005 Title: RFA AIDS Identifier: 2005/05 ZAT1 JH (09) Date: March 28 – 29, 2005 Research Support


ACTIVE SUPPORT Targeting Mechanisms of Opioid Misuse and Chronic Pain through Mindfulness- Oriented Recovery Enhancement. NIH NIADA R 34. 10/01/12 – 09/30/2014 Principal Investigator: Eric Garland Role: Consultant. 2% Integrative Medicine Program

HRSA: IMOHP 25106 9/30/2012 – 9/29/2014 Principal Investigator: Deborah Porterfield, UNC Dept. of Social Medicine Total Direct Costs $150,000

Education in complementary and alternative medicine for trainees in the UNC Preventive Medicine Residency program.

Role: Co-Investigator: 3% effort. Post Traumatic Headache and Psychological Health: Mindfulness for Mild TBI U.S. Department of Defense PT090084 8/01/2010 – 7/3/2013 Principal Investigator: Sutapa Ford

Total Direct Costs: $737,560 Mindfulness training in military personnel suffering mild traumatic brain injury in combat areas. Role: Co-Investigator: 10% effort. A Mindfulness-based Intervention to Reduce Diabetes Risk in Pre-diabetic African Americans. 1 R21 AT004276-01 NIH, NCCAM

7/01/2009 – 6/30/2012 Principle Investigator: Susan Gaylord Total direct costs: $400,000

Mindfulness training in pre-diabetic adults as a prevention strategy in African American adults.

Role: Co-Investigator: 5% effort. Complex Persistent Pain Conditions: Unique & Shared Pathways of Vulnerability NIH NIDR – P01-NS045685-06 6/01/2010 – 5/31/2015. Principal Investigator, William Maixner (UNC SoD) – Total direct cost: Phenotypic correlation, including clinical profile and physiologic responses to experimental pain, with genotypic profile and expression. Role: Sub-project (Migraine) Lead Investigator. 15 % effort. Genetic & Psychosocial Influences on Transition to Chronic TMD & Related Pain U01-DEO17018 (OPPERA II) NIH/NIDCR 8/7/2012-7/31/2017 Principle Investigator: William Maixner


Total direct costs: $3,516,609 The major goal of this project is to follow up/expound on studies from the OPPERA I project and reveal novel information regarding the etiology and pathophysiology of chronic pain.

Role: Co- Investigator 5% effort. Research Fellowship in Complementary and Alternative Medicine (CAM) T-32 AT003378 NIH/NCCAM 7/01/07 – 6/30/17 Principle Investigator: John Douglas Mann Total direct costs: $1,500,000

Offers up to a 3 year research fellowship leading to a sustainable academic career in complementary and alternative medicine research.

Role: Principal Investigator and Director, 5% effort, no direct salary. Exploratory Analgesic Dietary Intervention for Chronic Daily Headache. Mayday Foundation, New York RAMSeS A09-1254 6/01/2009 – 5/31/2012 Principal Investigators: John Douglas Mann, Christopher Ramsden Total direct costs: $240,000

Assessment of a low-inflammatory diet on headache frequency, intensity and duration in adults with migraine.

Role: Principal Investigator and Director, 10% effort. Therapeutic massage for management of pain & disability in tension-type headache. NIH NCCAM - R21-AT004469 7/01/09 – 6/30/2012 Principal Investigator: Albert Moraska, U. Colorado. Total direct costs: $400,000

Evaluation of the effectiveness of standard massage techniques in the treatment of tension type headache in adults. Feasibility study.

Role: Consultant, 2% effort. Effects of a Low Omega-6 and High Omega-3 Diet on Inflammatory Gene Expression in Patients with Chronic Daily Headaches. National Headache Foundation 05/01/2010 – 04/30/2011 Principal Investigator: John Douglas Mann. Total direct costs: $20,000

Supplemental funding to examine gene expression in subjects with chronic daily headache on high omega-3 and low omega-6 dietary intervention for headache.

Role: PI. No direct salary support. Funding is only for supplies to run assays.


State of North Carolina Budget Line – Item Appropriation

Funding Agency: State of North Carolina Awardee: John Douglas Mann, MD Title: Neurology: Clinical Pain Program Participation: Neurological Director and Budgeting Director Annual Award: $85,000/year (current funding level < $5,000) Dates: 1985-2005

COMPLETED FUNDED PROJECTS Craniosacral Therapy in Migraine: A Feasibility Study. 1 R21 AT002750-01 Mann (PI) 10/01/06 – 9/31/31/09 NIH/NCCAM $400,000

To evaluate the therapeutic effects of craniosacral therapy for migraine headaches in adults.

Role: Principal Investigator 20% effort Mindfulness for Irritable Bowel Syndrome 1 R21-AT003619-01 Gaylord (PI) 09/30/06 – 08/31/09 NIH/NCCAM

To evaluate the therapeutic effectiveness of mindfulness meditation as an intervention in women with IBS.

Role: Co-Investigator 5% effort Women’s Health Initiative Memory Study.

Bowman Gray 96-057 Shumaker (PI) 07/01/98 - 11/30/08 Wyeth Pharmaceuticals $2,000

To assess and follow women with suspected cognitive impairment over a period of years.

Role: Consultant and Examiner Painful HIV Neuropathy: Treatment with Alpha-Lipoic Acid. 1 R21 AT001775-01 Mann (PI) 07/01/03 – 3/31/07 NIH/NCCAM

To evaluate the therapeutic effects of oral alpha-lipoic acid in painful HIV-related neuropathy in adults.

Role: Principal Investigator 20% (completed) Mindfulness for Irritiable Bowel Syndrome (IBS).


UNC Center for Functional GI & Motility Disorders: Seed Grant Program Gaylord (PI) 04/24/06 – 4/23/09

This pilot is to collect preliminary data on the feasibility of conducting a larger study of mindfulness meditation training as an intervention in women with IBS.

Role: Co-Investigator 3% effort Integrating Complementary and Alternative Medicine into Health

Professions Education in North Carolina. 5-R25-AT00540-01. UNC School of Medicine Peter Curtis, MD - PI, Susan Gaylord, PhD - co-PI Agency: National Institutes of Health Institute: Center for Complementary and Alternative Medicine Total funding: $1.6 million Project Dates: 9/28/00 - 7/31/06. Participation: Co-Investigator -- 25% effort Training Family Caregivers in Hand and Foot Massage for Patients Undergoing

Inpatient Rehabilitation: Impact on Pain Relief, Symptom Profile and Participant Satisfaction.

PI: John Douglas Mann, MD Source: Press Ganey Associates, Inc. Total funding: $10,000 Project Dates: July 1, 2003 – June 31, 2005 Korean Acupuncture in Central Nervous System Disorders

1 R21 AT001952-01 PI: Mann, John Douglas Agency: NIH

Institute: Center for Complementary and Alternative Medicine Project Dates: 10/01/2003 - 3/31/2005 Total Direct Costs: $200,000 Percent Effort: 15%

North Carolina Academic Alliance for Integrative Medicine Kohlberg Foundation Principal Investigator: Kathy Kemper, MD

Wake Forest University Project Dates: 1/1/2004 -- 12/31/2005 Total Direct Cost: $50,000 Participation: Co-Investigator - 4%

The Greenwall Foundation

Title: End of Life Preferences of ALS Patients and Their Physicians Assumptions. A Pilot Project.

Role: Principal Investigator Project Dates: 1/1/2005 -- 12/31/2005 Total Direct Cost: $4,899 Participation: - 4%


UNC FUNDED PROJECTS: 2002 - 2003

Title: “Cerebral cortical habituation in migraine and normals, an

fMRI study .” Source: UNC Office of Research Services. Role: Principal Investigator Dates: April 2002 -- June 2003 Funding: $4,000.

Title: “Integrative Approaches in the Management of Headache.”

Source: UNC Education and Technology Group (ETG). Web Site Development Project

Role: Principal Investigator Dates: 2002 - 2003 Funding: $2,500 (awarded but lack of funds)

Title: “Assessing Health Related Quality of Life Among Patient in the UNC Headache Clinic.” Source: UNC Program on Health Outcomes. Role: Principal Investigator Dates: July 2000 -- June 2002 Funding: $8,000.

MULTIPLE SCLEROSIS PROJECT GRANTS Silva Markovic-Plese, MD, Associate Professor of Neurology Principal Investigator for the following projects

UNC Department of Neurology Chapel Hill, North Carolina 27599-7025

Dr. Mann, Co-Investigator

EDSS Examiner and Rater. Effort 2% depending on subject accrual for each of the following projects.

ACTIVE:

1. Genzyme Extension Trial, CAMMS03409: Eight subjects enrolled for 4 yrs in the extension part of the study. 2012 – 2015.

2. NIH-NIAID and ITN Sponsored ACCLAIM study, ITNA035AI : Two subjects

enrolled as of June 2012. 2011-2015.

3. ROCHE. OPERA: Enrollment begins September 2012. 2012 - 2014


4. A Phase II Randomized, Double-Blind, Parallel Group, Placebo Controlled,

Multi-Center Study to Evaluate the Safety and Efficacy of Abatacept in Adults with Relapsing Remitting Multiple Sclerosis. 2011-2014 Principal Investigator: Silva Markovic-Plese Sponsor: National Institute of Allergy and Infectious Diseases. Role: Consultant.

COMPLETED Multiple Sclerosis Projects: Early IFNb-1a (Avonex) and Zimvastatin (Zocor) Combination Therapy in Clinically Isolated Syndrome Suggestive of Multiple Sclerosis. Opened 2/2005 – completed 6/2008. Sponsor: Biogen.

Early IFNb-1a (Rebif) and Atrovastatin (Lipitor) Combination Therapy of Isolated Clinical Syndrome Suggestive of Multiple Sclerosis. Opened 2/2005 – 2008. Sponsor: EMD/Serono. 2007 – 2009 A Multi-Centered, Randomized, Double-Blind, Placebo Controlled Study Assessing the Add-On-Effect of Oral Steroids in Relapsing Remitting Multiple Sclerosis Subjects Treated with Glatiramer Acetate (GA). 2006 – 2010.

Sponsor: TEVA. 2007 - 2010 A 24 Month Double-Blind, Randomized, Multi-Centered, Placebo Controlled, Parallel Group Study. Efficacy and Safety of Daily Oral 0.5mg and 1.25mg fingolimod (FTY720) versus Placebo in Patients with Relapsing Remitting Multiple Sclerosis. Sponsor: Novartis. 2007 - 2010.

Contracts and Small Grants

Pre-gabalin in the treatment of post herpetic neuralgia. Start date September, 1998 Closed, April, 1999

Principal Investigator $7,500

Pre-gabalin in the treatment of low back pain. Start date -- closed label July, 1998. Open label. Principal Investigator: 2% effort $48,800


Pre-gabalin in the treatment of low back pain. Start date -- closed label July, 1999 Open label

Principal Investigator: 5% effort $28,000

Glaxo-Wellcome Pharmaceuticals

Title: Naratriptan: Treatment of Menstrual Migraine January, 2000 - July 2001 5% effort $57,000 Multi-center trial of naratriptan in women with menstrually related migraine.

Co-Investigator: 3% effort $57,000


TEACHING

During the past 5 years student feedback concerning my teaching efforts in the second year Neurosciences Course and in the two clinical years of bedside, clinic and didactic teaching, has been consistently positive. (Please contact Dr. Cheryl McNeil, UNC Department of Neurology, Third Year Medical School Neurology Rotation Director, for specific comments from students 2008 – 2013.) Neurosciences, Second Year Medical School (2009-2013): Hours lectured: 3/year.

Principals and Practices in Alternative and Complementary

Medicine. (Co-Director) Course PMED 250 Hours: 39. Hours lectured: 3/year Inpatient Bedside Teaching. During inpatient ward and consult attending rotations. Two to four students and two to four residents/interns are assigned each month to each adult neurology service. During the past five years, I have been assigned to one of those rotations from eight weeks per year. Teaching takes place during rounds, bedside examination of patients, literature distribution and through didactic presentations. Neurology Resident Teaching in Clinic: 0 to 2 days per week. Lectures Requested: Anesthesiology:

Family Medicine: Physical Medicine: Program on Integrative Medicine: Extra-institutional:

Examples of relevant teaching in complementary and alternative medicine.

“Annual Clinical Hypnosis Workshop for Health Care Professionals”

Duke University Center for Living, Durham, NC Three day workshops, April 2007 - 2013 Participation: Faculty Lecturer and Preceptor. A variety of topics presented; examples:

Pain Management and Physiologic Control with Hypnosis. Medical and Dental Utilizations in Hypnosis Self-Hypnosis Managing Resistance. Hypnosis in the Management of Headache. Constructing Metaphors and Indirect Suggestions Medical Utilizations in Hypnosis Utilizing Hypnotic Phenomenon.

“Integrative Approaches in the Management of Headache” Douglas D. Brendle Integrative Medicine Seminar Series, Wake Forest University School of Medicine, April 12, 2007.


“Seventh Annual Clinical Hypnosis Workshop for Health Care Professionals”

Duke University Center for Living, Durham, NC April 28-30, 2006. Participation: Faculty Lecturer and Preceptor.

“Cultivating the New Wellness-Driven Economy in North. Carolina. Integrative

medicine: A panel discussion of current issues.” The Third North Carolina Natural Products Association Conference: Boone, North Carolina, November 17-18, 2006.

“Complementary and Alternative Approaches to Pain Management” UNC Department of Medicine Grand Rounds, March 21, 2005. “Sixth Annual Clinical Hypnosis Workshop for Health Care Professionals”

Duke University Center for Living, Durham, NC April 29-May 1, 2005. Participation: Faculty Lecturer and Preceptor.

“Mindfulness Meditation in Pain Management.” 5th Annual Pain Conference. University of North Carolina School of Nursing, Friday Center, Chapel Hill, NC May 13, 2004

“Fifth Annual Clinical Hypnosis Workshop for Health Care Professionals”

Duke University Medical Center, Durham, NC April 30-May2, 2004. Participation: Faculty Lecturer and Preceptor.

“Integrative Medicine in the Management of Headache.” The Sixth Annual

Integrative Medicine Seminar. Cambri-Somerset Council for Education of Health Professionals, University of Pittsburgh at Johnstown, Conemaugh Health Systems, Johnstown, Pa, March 29, 2004

“Integrating Conventional and Alternative Approaches to Pain Approaches.” The

Third Annual Pain Management Symposium. Sponsored by the New Hanover Medical Consortium. Wilmington, N.C. November 21, 2003.

“Principles of Integrative Therapeutics.” The 4th UNC Conference on Integrating

Complementary and Alternative Medicine into Clinical Practice: Expanding Choices in Healing and Health Care. Chapel Hill, N.C., March 14, 2003.

“Self-Hypnosis for Prersonal Health and Healing.” A workshop for patients

with chronic disease. Sponsored by the Turning Point Education and Research Foundation. Presbyterian Hospital Buddy Kemp Caring House, Charlotte, NC, March 1, 2003.

“The Impact of Language on Healing.” A workshop for health care

providers. Sponsored by the Turning Point Education and Research Foundation. Presbyterian Hospital Buddy Kemp Caring House, Charlotte, NC, February 28, 2003.

“Integrative Options in the Management of Headache”. Mountain AHEC

CME Conference, Asheville, North Carolina, July 25, 2002


“Third Annual Clinical Hypnosis Workshop for Health Care Professionals” Duke Center for Living, Durham, NC April 26-28, 2002. Participation: Faculty Lecturer and Preceptor.

“Taking Charge of Your Health: Complementary and Alternative Approaches to Chronic Pain.” Carolina Women’s Forum, Chapel Hill, March 16, 2002. "Enhancing Communication Skills: Patient – Physician

Encounters." Introduction to Integrative Medicine. Chapel Hill, N.C., February 8, 15, 2000; February 19 and March 19, 2002.

“Principles and Practices of Alternative and Complementary Medicine”, FMME 250. Faculty Advisor and Course Co-Director. August-December, 2001.

Johnson Scholars Honors Seminar on Complementary and Alternative Medicine. Course Co-Director. August – September, 2001.

"Integrating Alternative and Complementary Therapies with Conventional Health Care." AHEC Continuing Medical Education Series, Rutherford Hospital, Inc., Rutherfordton, NC. October 13, 2001. (with Susan Gaylord, PhD).

"Mindfulness for Stress Management." UNC Psychology Interns Seminar Series.

Horace Williams House. May 4, 2001. "Integrative Medicine." Integrate! (Medical Student Holistic Interest Group), Berryhill Hall, UNC, Chapel Hill, September 6, 2000.

"Integrative Medicine Strategies for Pain Management." Complementary and Alternative Medicine in Cancer: Real Change for the Real World - 5th Annual Integrating Mind, Body and Spirit in Medical Practice. November 18, 2000.

"Emerging Therapies for the Treatment of Headaches: Magnesium

and Botulinum Toxin." North Carolina Neurological Society, Annual Meeting, Greensboro, N.C., November 6, 1999.

"Chronic Pain Syndromes: Integrating Alternative and

Conventional Approaches." Fourth Annual Wake AHEC Alternative and Complementary Therapies Symposium, Raleigh, NC, May 18-19, 1999.

"Overview of Non-Pharmacological Approaches to Pain Management" and panel

participant. Fourth Annual Alternative & Complementary Therapies Symposium: Treatment of Chronic Non-Malignant Pain, Wake AHEC, Raleigh, NC, May 18-19, 1999.

"Complementary Therapies in Migraine Management." Principles


Headache Management in the New Millennium. CME Course for Family Practitioners, Sponsored by Carolina Headache Centers, Chapel Hill, NC, May 1, 1999.

INVITED LECTURES

“Complementary and Alternative Medicine in Neurological Disorders” Neurology Resident’s Conference, UNC Hospitals, Chapel Hill.

“Low Back Pain” Neurology Resident’s Conference, UNC Hospitals, Chapel Hill. Yearly up to 2005

“Diagnosis and Management of Increased Intracranial Pressure” Neurology Resident’s Conference, UNC Hospitals, Chapel Hill.

“The Neurological Examination” Neurology Resident’s Conference UNC Hospitals, Chapel Hill. “Current Pain Management Strategies” Neurology Residents Conference, UNC

Hospitals, Chapel Hill. ADDITIONAL RECURRENT CLINICAL TEACHING

Lectures on neurological stress and other neurological topics given to third and fourth year medical students and trainees throughout the academic year.

Bedside teaching in the neurology outpatient unit to residents and student approximately 6 days per month.

Ward associated teaching 8 weeks per year. CURRENT SPECIAL INTERESTS

Clinical research, diet and migraine, diet and chronic daily headache, mindfulness training and post traumatic headache, mindfulness and IBS, complementary and alternative medicine (CAM) in neurological disorders, integrative medicine, mind – body medicine, chronic pain, opiates in chronic pain.


CLINICAL ACTIVITIES (March 2013) . This level of clinical activity is

representative of efforts on average for the past 4 years.

Adult Neurology Inpatient Ward or Consults. Eight weeks per year. Rotations are 1 to 2 weeks at a time. Although these are full weeks with clinical rounds several times per day and many notes to sign, resident, intern and student participation facilitate clinical service while providing multiple teaching opportunities. Clinic. Includes one full day per week seeing patients newly referred for evaluation of headache, and one half day per week seeing follow-up patients. Weeks when I am on an inpatient rotation, I see only add-on patients.

Clinic. It also includes one day per week at Central Prison in Raleigh where I see between 8 and 12 new and return inmate patients per session referred for evaluation of neurological problems. Inpatient consultation is in the prison hospital also provided on those days. There are no residents, fellows or students.

Clinic. It also includes one day per month at Women’s Correctional Facility in Raleigh seeing between 8 and 12 new and return inmate patients per session referred for evaluation of neurological problems. There are no residents, fellows or students.

Complementary and Alternative Medicine Consultation Requests. Currently developing a multidisciplinary consult team to respond to requests by UNC clinical faculty and UNC-based patients. Numbers have grown to 3-5 per month, primarily from Oncology and GI Services.


Refereed Publications. Adelman, L.S., Mann, J.D., Caley, D.W., and Bass,N.H.: Neuronal lesions in the

cerebellum following the administration of excess phenylalanine to neonatal rats. Journal of Neuropathology and Experimental Neurology, 32:380-394, 1973.

Agusta, V.E., Gillenwater, J.L.Y., and Mann, J.D.: Post-operative bleeding associated

with Levodopa therapy. Journal of Urology, 110:574-576, 1973. Mann, J.D., Johns, T.R., Campa, J.F., and Muller, W.H.: Long term administration of

corticosteroids followed by thymectomy. Transactions of the American Neurological Association, 100:63-68, 1975.

Mann, J.D. and Bass, N.H.: Acute uremic encephalopathy in the rat: defective sink

action of the cerebrospinal fluid for acid metabolites. Transactions of the American Neurological Association, 100:218-220, 1975.

Mann, J.D., Johns, T.R., Campa, J.F., and Muller, A.H.: Long-term prednisone followed

by thymectomy in myasthenia gravis. Ann. N.Y. Acad. Sci., 274:608-622, 1976. Mann, J.D., Johns, T.R., Campa, J.F.: Long-term administration of corticosteroids in

myasthenia gravis. Neurology, 26:729-740, 1976. Mann, J.D., Maffeo, C.J., Rosenthal, J.D., Johnson, R.N., Butler, A.B., and Bass, N.H.:

Regulation of intracranial pressure in rat, dog, and man: Manometric assessment of cerebrospinal fluid dynamics using a constant-flow perfusion system. Transactions of the American Neurological Association, 101:182-185, 1976.

Maffeo, C.J., Mann, J.D., Butler, A.B., Bass. N.H., and Johnson, R.N.: Constant flow

perfusion of the cerbrospinal fluid system of rat, dog, and man: A mathematical model. In S. Saha (Ed.), Proceedings IV New England Bioengineering Conference, 447-450. Pergamon Press, N.Y., 1976.

Bass, N.H., Mann, J.D., and Young, E.A. The blood-cerebrospinal fluid barrier and its

role in the development of tolerance to the respiratory depressant effects of morphine. Problems of Drug Dependence, 291-304, 1977.

Mann, J.D., Butler, A.B., Rosenthal, J.D., Maffeo, C.J., Johnson, R.N., and Bass. N.H.:

Regulation of intracranial pressure in rat, dog and man. Annals of Neurology, 3:156-165, 1978.

Butler, A.B., Mann, J.D., Bass, N.H., and Jane, J.A.: Cerebrospinal fluid transport

mechanisms in the arachnoid villus. Proceedings of the American Association of Neurological Surgeons: 181-183, 1978.

O'Neill, B.P. and Mann, J.D.: Aspirin prophylaxis in migraine. Lancet, 2: 1179-1181,

1978.


Maffeo, C.J., Van Landingham, K.E., Mann, J.D., Butler, A.B., Bass, N.H., and Johnson R.N.: Model predicted parameters critical to intracranial pressure regulation. Proceedings of the Ninth Annual Conference on Modeling and Simulation, W.G. Vogt and M.H. Mickle (Eds.), ISA Press, Philadelphia, PA, pp 307-312, 1978.

Johnson, R.N., Maffeo, C.J., Mann, J.D., Butler, A.B., and Bass, N.H.: Intracranial

pressure regulation: A comparative model of cerebrospinal fluid systems. Tower International Technomedical Institute Journal of Life Sciences, 8:79-92, 1979.

Mann, J.D., Butler, A.B., Johnson, R.N., and Bass, N.H.: Clearance of macromolecular

and particulate substances from the cerebrospinal fluid system of the rat. J. Neurosurgery, 50:343-348, 1979.

Snider, W.D., DeMaria, A.A., and Mann, J.D.: Diazepam and dialysis encephalopathy.

Neurology, 29:414-415, 1979. Bass, N.H., Maffeo, C.J., Van Landingham, K., Mann, J.D., Kasarskis, E.J., Butler,

A.B., and Johnson, R.N.: Mathematical modeling of mechanisms controlling the third circulation: Its clincal importance in health and disease. Modeling and Simulation, 10:1-4, 1979.

Johnson, R.N., Mann, J.D., Maffeo, C.J., Kasarskis, E.J., Butler, A.B., and Bass, N.H.:

Intracranial pressure regulation: Quantitative assessment of outflow resistance, fluid formation and intracranial compliance. Modeling and Simulation, 10:11-16, 1979.

Mann, J.D., Cookson, S.L., and Mann, E.S.: Differential effects of pentobarbital,

ketamine and enflurane on cerebrospinal fluid outflow resistance and production rate in the rat. In Intracranial Pressure IV (Shulman, K., Marmarou, A., Miller, J.D. et. al., eds.), Springer-Verlag, New York: 466-471, 1980.

Kim, C.S., O'Tuama, L.A., Cookson, S.L. and Mann, J.D.: The effects of lead

poisoning on calcium transport by brain in 30-day old albino rabbits. Toxicology and Applied Pharmacology, 52:491-496, 1980.

Cookson, S.L. and Mann, J.D.: Phenytoin reversal and prevention of morphine-induced

catelepsy in the rat. Pharmacol. Biochem. and Behav., 12:743-746, 1980. Mann, J.D.: "Neurology." In: A Guide to the Study of Internal Medicine, R. E.

Colindres and W. D. Mattern, (Eds.), University of North Carolina Press, Chapel Hill, NC, pp 114-183, 1980.

Bhagat, A., Traurig, H., Bass, N.H., Mann, J.D., and Furlow, T.W.: Central nervous

system facilitation of cardiac arrhythmia: Selective localization of digoxin receptor sites for NA+-K+ATPase on neurons in dorsal vagal nucleus. Transactions of the American Neurological Association, 106:441-444, 1980.


Bass, N.H., Traurig, H.H., and Mann, J.D.: Selective vascular permeability to digoxin and the inhibition of Na - K adenosine triphosphatase in the brain stem. Experimental Neurology, 78:602-615, 1982.

Grimson, B.S., Mann, J.D., and Pantell, J.P.: Optic nerve pit during papilledema.

Archives of Ophthalmology, 100:99-100, 1982. Mann, J.D. and Mann, E.S.: "Differential Effects of Pentobarbital, Ketamine

Hydrochloride, Enflurane and Halothane on CSF Dynamics." In: Neurobiology of Cerebrospinal Fluid II, James H. Wood (Ed.), Plenum Pub. Corp., New York. pp 753-764, 1983.

Mann, J.D., Johnson, R.N., Butler, A.B., and Bass, N.H.: "Impairment of CSF

Circulatory Dynamics in Pseudotumor Cerebri and Response to Steroid Treatment." In: Neurobiology of Cerebrospinal Fluid II, James H. Wood (Ed.), Plenum Pub. Corp., New York. pp 739-752, 1983.

Johnson, R.N., Butler, A.B., Mann, J.D., and Bass, N.H.: "Intracranial Hypertension in

Experimental Animals and Man: A Quantitative Approach to System Dynamics of Circulatory CSF." In: Neurobiology of Cerebrospinal Fluid II, James H. Wood (Ed.), Plenum Pub. Corp., New York. pp 697-706, 1983.

Butler, A.B., Johnson, R.N., Mann, J.D., and Bass, N.H.: "Mechanisms for CSF

Transport in the Normal and Pathologically Altered Arachnoid Villi." In: Neurobiology of Cerebrospinal Fluid II, James H. Wood (Ed.), Plenum Pub. Corp., New York. pp 707-726, 1983.

Kim, C.S., O'Tuama, L.A., Mann, J.D. and Roe, C.R.: Saturable accumulation of the

anionic herbicide, 2,4-D, by rabbit choroid plexus: Early developmental origin and interaction with salicylates. J. Pharmacol. Exp. Ther., 225:699-704, 1983.

Kim, C.S., O'Tuama, L.A., Mann, J.D., and Roe, C.R.: Effect of increasing carbon chain

length on organic transport by the choroid plexus: A potential factor in Reye's syndrome. Brain Research, 259:340-343, 1983.

Charlton, J.D., Johnson, R.N., Pederson, N.D., and Mann,J.D.: Assessment of

cerebrospinal fluid outflow resistance in intracranial compliance: Analysis of steady state response to sinusoidal input. Ann. Bio. Med. Eng., 11:551-561, 1983.

Johnson, R.N. and Mann, J.D.: "Integrated quantitative experimental analyses of the ICP

control system." In: Hydrocephalus, K. Shapiro, A. Marmarou and H. Portnoy, Eds., Raven Press, New York. pp 179-192, 1984.

Guess, H.A., Charlton, J. D., Johnson, R.N., and

Mann, J. D.: A non-linear least squares method for determining cerebrospinal fluid formation and absorption kinetics in pseudotumor cerebri. Comput. and Biomed. Res., 18:184-192, 1985.


The EC/IC Bypass Study Group: The international cooperative study of extracranial/intracranial arterial anastomosis (EC/IC Bypass Study): Methodology and entry characteristics. Stroke, 16:397-406, 1985.

The EC/IC Bypass Study Group: Failure of extracranial- intracranial arterial bypass to

reduce the risk of ischemic stroke: Results of an international randomized trial. New Eng J. Med, 313:1191-1200, 1985.

Mann, J.D., Charlton, J.D., Pederson, N.E., Cookson, S.L., and Johnson, R.N.:

"Reduction in cerebrospinal fluid transport mediated by lead acetate in the in vitro superior sagittal sinsus of the dog." In: Intracranial Pressure VI, G.M. Teasdale, et al (Eds.), Springer Verlag, New York, pp. 624-628, 1986.

Haynes, R.B., Mukherjee, J., Sackett, D.L., Taylor, D.W., Barnett, H.J.M., Peerless, S.J.,

and The EC/IC Bypass Study Group: Functional status changes following medical or surgical treatment for cerebral ischemia. JAMA: 257(15):2043-2046, 1987.

Charlton, J.D., Guess, H.A., Mann, J.D., Nagle, H.T., and Johnson, R.N.: A pressure

controller for estimating parameters for a nonlinear CSF model. IEEE Trans. Biomed. Eng., 35:752-755, 1988.

Toomey, T.C., Mann, J. D., Abashian, S. and Thompson-Pope, S.: Relationship between

perceived self-control of pain, pain description and functioning. Pain 45: 129-134, 1991.

Toomey, T.C., Mann, J.D., Abashian, S., and Thompson-Pope, S.: Relationship of pain

drawing scores to ratings of pain description and function. Clin. J. Pain 7: 269-274, 1991.

Kim C.S., Roe, C.R., Mann, J.D., and Breese, G.R.: Octanoic acid produces

accumulation of monoamine acidic metabolites in the brain: Interaction with organic anion transport at the choroid plexus. J. Neurochem. 58: 1499-1503, 1992.

Mann, J.D. and Eckel, R.W.: "Headache: Assessment and Treatment." In: Manual of

Clinical Problems in Adult Ambulatory Care. Dornbrand, L. and Hoole, A.J. (Eds.) Little, Brown and Company, Boston, pp 457-469, 1992.

Mann, J.D. and Lundeen, T.F.: "Headache and Facial Pain" In: Head and Neck Surgery - Otolaryngology. Byron J. Bailey, Ed. J.B.

Lippincott Co., Philadelphia pp 763-773, 1993. Mann, J.D.: Brain abscess and parameningeal infection. In: Current Therapy in

Neurological Disease, R.T. Johnson and J.W. Griffin, Eds., C.B. Decker, St. Louis, pp 113-119, 1993.


Toomey, T.C., Mann, J.D., Hernandez, J.T. and Abashian, S.W.: Psychometric characteristics of a brief measure of pain related functional impairment. Archives of Physical Medicine and Rehabilitation 74:1305-1308, 1993.

Toomey, T.C. Mann, J.D. and Abashian, S.W.: Sexual/physical abuse in patients with

chronic pain: Relationship to pain description, location and control attribution. Psychosomatic Medicine 55: 106-108, 1993.

Toomey, T.C., Mann, J.D., Abashian, S.W., Carnrike, C.L.M., and Hernandez, J.T.:

Pain locus of control scores in chronic pain patients and medical clinic patients with and without pain. The Clinical Journal of Pain 9: 242-247, 1993.

Cheshire, W.P., Abashian, S.W. and Mann J.D.: Botulinum toxin in the treatment of

myofascial pain syndrome. Pain 59: 65-70, 1994. Dalton, J.A., Bernard, S., Blau, W., Johnston, C., Mann, J.D., Germino, B., Pierce, S.,

Toomey, T., Mooney, D. and Carlson, J.: Managing cancer pain: Content and scope of an education program for nurses who work in predominantly rural areas. Journal of Pain and Symptom Management 10: 214-223, 1995.

Toomey, T.C., Seville, J.L., Mann, J.D., Abashian, S.W. and Grant, J.R.: Relationship of

sexual and physical abuse to pain description, coping, psychological distress and health care utilization in a chronic pain sample. The Clinical Journal of Pain 11: 307-315, 1995.

Toomey, T.C., Seville, J.L., Mann, J. D., Abashian, S.W. and Wingfield, M. S.:

Relationship of learned resourcefulness to measures of pain description, psychopathology, and health behavior in a sample of chronic pain patients. The Clinical Journal of Pain 11: 259-266, 1995.

Toomey, T.C., Seville, J. and Mann, J.D.: The pain locus of control scale: Relationship

to pain description, self-control skills and psychological symptoms. The Pain Clinic 8: 315-322, 1995.

Dalton, J.A., Blau, W., Carlson, J., Mann, J.D., Bernard, S., Toomey, T., Pierce, S. and

Germino, B.: Changing the relationship between nurses' knowledge, self reported behavior and documented behavior: Does education make a difference? J. Pain and Symptom Management 12: 308-319, 1996.

Finkel, A.G. and Mann, J.D.: "Headache: Assessment and Treatment." In: Manual of

Clinical Problems in Adult Ambulatory Care, Third Edition. Dornbrand, L., Hoole, A.J. and Fletcher, R.H.(Eds.) Lippincott-Raven, New York, pp 429-445, 1997.

Toomey, T.C., Seville, J.L., Finkel, A.G., Mann, J.D., Abashian, S.W., and Klocek,

J.W.: Circumstances of chronic pain onset: relationship to pain description, coping and psychological distress. The Pain Clinic 10: 19-26, 1997.


Finkel, A.G., Howard, J.F. and Mann, J.D. Successful treatment of headache related to intravenous immunoglobulin with antimigraine medications. Headache 38: 317-321, 1998.

Finkel, A.G., Toomey, T.C., Abashian, S. and Mann, J.D.: Methadone in chronic non-

malignant pain: a retrospective study. The Pain Clinic 10: 235-243, 1998. Rowbotham, M., Harden, N., Brett, S., Stacey, B. Bernstein, P., Magnus-Miller, L. and

the Gabapentin Postherpetic Neuralgia Study Group. Gabapentin for the treatment of post herpetic neuralgia: A randomized controlled trial. JAMA 280, 1837-1842, 1998.

Dalton, J.A., Carlson, J., Mann, J.D., Blau, W.S. and Bernard, S.A. Pain management

issues: The cost of medications in rural settings. The Hospice Journal 13: 19-32, 1998.

Dalton, J.A., Carlson, J., J., Mann, J.D., Blau, W.S., Bernard, S.A. and Youngblood, R.

An examination of nursing attitudes and pain management practices. Cancer Practice 6: 115-124, 1998.

Taylor, W.F., Finkel, A.G., Robertson, K.R., Anderson, A. C., Toomey, T.C., Abashian,

S.A. and Mann, J.D.: Methadone in the treatment of chronic non-malignant pain: A two year follow-up study. Pain Medicine 1: 254-259, 2000.

Curtis, P., McDermott, J., Gaylord, S., Mann, D., Norton, S., Motyka, T. and Tresolini,

C. Preparing complementary and alternative practitioners to teach learners in conventional health professions. Alternative Therapies in Health and Medicine 8: 54-59, 2002.

Jacobson, PL and Mann, JD: Evolving role of the neurologist in the diagnosis and

treatment of chronic non-cancer pain. Mayo Clinic Proceedings 78: 22-27, 2003. Jacobson, PL and Mann, JD. The valid informed consent-treatment contract in chronic

non-cancer pain: Its role in reducing barriers to effective pain management. Contemporary Therapy, 30: 101-104, 2004.

Mann D, Gaylord S, Norton S. Moving toward integrative care: Rationales, models, and

steps for conventional-care providers. Complementary Health Practice Review 9: 155-172, 2004

Lindzen E, Gilani A, Markovic-Plese S and Mann D. Acute disseminated

encephalomyelitis following liver transplantation. Archives of Neurology 62: 650-652, 2005.

Kim YS, Wang J, Mann JD, Gaylord SG, Lee HJ, Lee M. Korean oriental medicine in


stroke care. Complementary Health Practice Review 10: 105-117. 2005. Coeytaux R, Kaufman JS, Kaptchuk TJ, Chen W, Miller WC, Callahan LF, Mann JD. A

randomized controlled trial of acupuncture for chronic daily headache. Headache 45: 1113-1123, 2005.

Kawata AK, Coeytaux R, DeVellis RF, Finkel A, Mann JD, Kahn K. Psychometric

properties of the HIT-6 among patients in a headache-specialty practice. Headache 45: 638-643, 2005.

Coeytaux RR, Kaufman JS, Chao R, Mann JD, DeVellis RF. Four methods of estimating

the minimal important difference of the Headache Impact Test. J. of Clinical Epidemiology 59: 374-380, 2006.

Calhoun AH, Ford S, Finkel AG, Kahn K, Mann JD. The prevalence and spectrum of

sleep problems in women with transformed migraine. Headache 46: 604-610, 2006.

Register-Mihalik J, Guskiewicz KM, Mann, JD, Shields E. Effects of headache on

clinical measures of neurocognitive function. Clinical Journal of Sports Medicine 17: 282-288, 2007.

Gaylord SA, Mann JD: Rationales for CAM education in health professions training

programs. Academic Medicine 82: 927-933, 2007. Nedrow AR, Heitkemper M, Frenkel M, Mann D, Wayne P, Hughes E: NCCA

project experience: Collaboration between allopathic and CAM health professionals. Academic Medicine 82: 962-966, 2007.

Faurot KR, Gaylord SA, Mann, JD. Training family care-givers in hand and foot

massage for hospitalized patients: Feasibility, challenges and lessons learned. Complementary Health Practice Review 12: 203-226, 2007.

Kreitzer MJ, Mann D, Lumpkin M. CAM competencies of the health professions.

Complementary Health Practice Review: 13: 63-72, 2008. Ford S, Calhoun A, Kahn K, Mann JD, Finkel A. Predictors of disability in

migraineurs referred to a tertiary clinic: Neck pain, headache characteristics, stress, and coping behaviors. Headache: The Journal of Head and Face Pain 48: 523-528, 2008.


Mann JD, Faurot KR, Wilkenson L, Curtis P, Coeytaux RR, Suchindran C, Gaylord S. Craniosacral therapy for migraine: Protocol development for an exploratory controlled clinical trial. BMC Complementary and Alternative Medicine 8: 28-34 2008. PMCID: PMC2442042

Gaylord S, Whitehead W, Coble R, Faurot K, Palsson O, Garland E, Frey W and

Mann JD. Mindfulness for irritable bowel syndrome: Protocol development for a controlled clinical trial. BMC Complementary and Alternative Medicine, 9: 24-30, 2009

Register-Mihalik JK, Guskiewicz KM, Valovich-McLeod TV and Mann JD.

Headache-related disability reported by collegiate athletes. Athletic Training and Sports Healthcare, 5: 227-233, 2009.

Fisher K, Calhoun A, Ford S, Mann JD and Finkel A. Patient characteristics associated

with frequent calls to a headache specialty clinic. Post Graduate Medicine 123: 177-182, 2011.

Curtis P, Gaylord S, Park J, Faurot K, Coble R, Suchindran C, Coeytaux R, Wilkinson

L, and Mann JD. Credibility of low strength static magnet therapy as an attention control intervention for a randomized controlled study of craniosacral therapy for migraine headaches. Journal of Alternative and Complementary Medicine, 17:711-721, 2011.

Gaylord SA, Palsson OS, Garland EL, Faurot KR, Coble RS, Frey W, Mann JD,

Whitehead WE. Mindfulness training reduces the severity of irritable bowel syndrome in women: Results of a randomized controlled trial. American Journal of Gastroenterology 106:1678-1688, 2011.

Ramsden CE, Mann JD, Faurot KR, Lynch C, Syed T Imam, Beth A MacIntosh, Joseph

R Hibbeln, James Loewke, Sunyata Smith, Rebecca Coble, Chirayath Suchindran and Susan A Gaylord. Low omega-6 vs. low omega-6 plus high omega-3 dietary intervention for chronic daily headache: Protocol for a randomized clinical trial. Trials Journal 12, 97: 2011.

Moura VL, Faurot KR, Gaylord SA, Mann JD, Sill M, Lynch C, Lee MY.

Mind-body interventions for treatment of phantom limb pain in persons with amputation. Am Journal of Physical Medicine and Rehabilitation, 91: 701-714, 2012.


Gaylord SA, Palsson OS, Garland EL, Faurot KR, Coble RS, Frey W, Mann JD, itehead WE. Mindfulness training reduces the severity of irritable bowel syndrome in women: Results of a randomized controlled trial. American Journal of Gastroenterology 106: 1678-1688, 2011.

Ramsden CE, Mann JD, Faurot KR, Lynch C, Imam ST, MacIntosh BA, Hibbeln JR,

Loewke J, Smith S,Coble R, Suchindran C, Gaylord SA. Low omega-6 vs. low omega-6 plus high omega-3 dietary intervention for Chronic Daily Headache: Protocol for a randomized clinical trial. Trials 2011 Apr 15;12:97. doi: 10.1186/1745-6215-12-97. 2011.

Garland, EL, Gaylord SA, Palsson O, Faurot K, Mann JD, Whitehead WE. Therapeutic

mechanisms for a mindfulness-based treatment for IBS: Effects on visceral sensitivity, catastrophizing, and affective processing of pain sensations. Journal of Behavioral Medicine, Dec 8 [Epub ahead of print] 2011.

Gaylord SA, Palsson OS, Garland EL, Faurot KR, Mann JD, Whitehead WE. Reply to “A Mindful Way Through IBS: Reducing Abdominal Pain And Improving Quality Of Life”. Gastroenterology 142(5): 1450, 2012. Ramsden CE, Ringel A, Feldstein AE, Taha AY, Macintosh BA, Hibbeln JR, Majchrzak-

Hong SF, Faurot KR, Rapoport SI, Cheon Y, Chung YM, Berk M, Mann JD. Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. Prostaglandins Leukotrienes and Essential Fatty Acids. Oct-Nov 87: 135-141, 2012.

Macintosh BA, Ramsden CE, Faurot KR, Zamora D, Mangan M, Hibbeln JR, Mann JD.

Low n-6 plus high-n-3 diets for use in clinical research. British J. Nutrition. Jan 18: 1-10; [Epub ahead of print] 2013


BOOK CHAPTERS Finkel, A.G., Lundeen, T.F. and Mann, J.D.: “Headache and Facial Pain” (Chapter) In:

Head and Neck Surgery - Otolaryngology. Byron J. Bailey, Ed. J.B. Lippincott Co., Second Edition, Philadelphia, pp 287-304, 1998.

Tennison, M.B. and Mann, J. D.:“Cerebral edema.” In: Essence of Pediatrics Stockman,

J.A.. and Lohr, J.A. (Eds.) W.B. Saunders Co., Philadelphia, 67-70, 2001. Mann, JD and Coeytaux, R: “Integrative Options in the Management of Migraine and

Tension-Type Headache”. In: Integrative Medicine, D. Rakel, Ed. Saunders, Philadelphia, 65-76, 2003.

Jacobson, PL and Mann, JD: "Parkinson’s Disease." In: Netter's Textbook of Internal

Medicine, A. Greganti (Ed.) Icon Press, N.Y., 689-693, 2003. Mann, JD and Gaylord, SA: "Multiple Sclerosis." In: Netter's Textbook of Internal

Medicine, A. Greganti (Ed.) Icon Press, N.Y., 671-678, 2003. Mann, D: “HeartMath.” In: Complementary Medicine in Clinical Practice, D. P. Rakel and N. Faas (Eds.) Jones and Bartlett Publishers, Boston, 169-176, 2006. Mann, JD and Coeytaux, R: “Migraine and Tension-Type Headache”. In: Integrative

Medicine, Second Edition, D. Rakel, Ed. Saunders, Philadelphia, 143-156, 2007. Markovic S, Gaylord SA, Mann JD. “Multiple Sclerosis.” In: Netter’s Textbook of

Internal Medicine, A. Greganti (Ed.), Second Edition, Icon Press, N.Y., pp 933-940, 2008.

Huang X, Jacobson PL, Mann JD. “Parkinson’s Disease.” In: Netter’s Textbook of

Internal Medicine, A. Greganti (Ed.), Second Edition, Icon Press, N.Y., pp 917-922, 2008.

Mann, JD and Coeytaux, R: “Headache”. In: Integrative Medicine, Third Edition, D.

Rakel, Ed. Saunders, Philadelphia, pp. 91-101; 2012.


ABSTRACTS Johns, T.R., Mann, J.D., Campa, J.F., and Joseph, B.S.: Long-term administration of

corticosteroids in myasthenia gravis. Neurology, 22:400, 1972. Mann, J.D. and Johns, T.R.: Long term administration of corticosteroids followed by

thymectomy. Arch. Neurol., 32:351, 1975. Mann, J.D., Butler, A.B., and Bass, N.H.: Identification of the major site of

cerebrospinal fluid efflux in the albino rat. Society for Neuroscience Abstracts, Volume 1:326, 1975.

Mann, J.D., Maffeo, C.J., Rosenthal, J.D., Johnson, R.N., Butler, A.B., and Bass, N.H.:

Regulation of intracranial pressure in rat, dog and man: Manometric assessment of cerebrospinal fluid dynamics using a constant-flow perfusion system. Arch. Neurol., 33:392, 1976.

Butler, A.B., Mann, J.D., and Bass, N.H.: Vesicular transport of peroxidase across the

endothelium of the rat arachnoid villus. Anatomical Record, 187:543, 1977. Maffeo, C.J., Mann, J.D., Butler, A.B., Bass, N.H., and Johnson, R.N.: Constant flow

perfusion of the cerebrospinal fluid system of rat, dog, and man: A mathematical model. J. Biotelemetry, 2:144, 1975.

Mann, J.D., Young, E.A., and Bass, N.H.: Role of the blood-cerebrospinal fluid barrier

in the development of tolerance to the respiratory depressant effects of morphine. Society for Neuroscience Abstracts, Volume 3:296, 1977.

Cookson, S.L., Mann, J.D., Kim, C.S., Gatzy, J.T., and O'Tuama, L.A.: The effects of

lead intoxication on the brain uptake of calcium in adult albino rabbits. Society for Neuroscience Abstracts, Volume 3:311, 1977.

O'Tuama, L.A., Kim, C.S., Mann, J.D., and Gartzy, J.T.: Increased permeability of

periventricular tissues in lead poisoning. Society for Neuroscience Abstracts, Volume 3:320, 1977.

Szyper, M.D. and Mann, J.D.: Anorexia nervosa as an interictal symptom of partial

complex seizures. Neurology, 28:335, 1978. Mann, J.D. and Bass, N.H.: Role of cerebrospinal fluid in morphine and enkephalin

induced respiratory depression. Transactions of the American Society for Neurochemistry, 9:189, 1978.

Mann, E.S., Cookson, S.L. and Mann, J.D.: Comparative effects of ketamine

hydrochloride and pentobarbital on cerebrospinal fluid formation rate and outflow resistance in the rat. Abstracts of Scientific Papers, American Society of Anesthesiologists, 413-414, 1978.


Kim, D.S., O'Tuama, L.A., Cookson, S.L., and Mann, J.D.: The effects of lead poisoning on calcium transport by the brain in 30-day old albino rabbits. Society for Neuroscience Abstracts, Volume 3:318, 1978.

Cookson, S.L. and Mann, J.D.: Reversal and prevention of acute morphine induced

catalepsy by phenytoin in naive rats. Society for Neuroscience Abstracts, Volume 4:488, 1978.

Mann, J.D., Johnson, Butler, A.B., and Bass, N.H.: Impairment of cerebrospinal fluid

circulatory dynamics in pseudomotor cerebri and response to steroid treatment. Neurology, 29:550, 1979.

Johnson, R.N., Maffeo, C.J., Kasarskis, E.J., Mann, J.D., Butler, A.B., and Bass, N.H.:

System regulation of intracranial hypertension: A model technique to assess abnormal mechanisms and response to therapy. Neurology, 29:534, 1979.

Mann, E.S., Cookson, S.L., and Mann, J.D.: Effects of enflurane and halothane on CSF

dynamics in the rat. Anesthesiology, 51, 3 Supplement: 54, 1979. Mann, J.D., Cookson, S.L., and Mann, E.S.: Comparative effects of pentobarbital,

ketamine, enflurane and halothane on cerebrospinal fluid dynamics in the rat. Society for Neuroscience Abstracts, Volume 5:408, 1979.

Mann, J.D. and Cookson, S.L.: Impaired cerebrospinal fluid absorption in the

developing rabbit following exposure to lead. Society for Neuroscience Abstracts, 6:829, 1980.

Bhagat, A., Mann, J.D., Furlow, T.W., Traurig, H., and Bass, N.H.: Digoxin-induced

cardiac arrhythmia: Digitalization of receptor sites in brainstem. Annals of Neurology, 8:126, 1980.

Charlton, J.D., Cookson, S.L., Pederson, N.E., Johnson, R.N., and Mann, J.D.: The

effect of lead on CSF transport in the isolated superior sagittal sinus of the dog. Society for Neuroscience Abstracts, 7:87, 1981.

Mitchell, W.G., Cookson, S.L., and Mann, J.D.: Effects of lead on behavioral responses

to morphine in juvenile rats. Clinical Research, 29:892, 1981. O'Tuama, L.A., Mann, J.D., Kim, C.S., Roe, D.R., Pederson, N.E., Sutton, C.: Reye

encephalopathy: An animal model per-mitting simultaneous assessment of blood-brain barrier function, intracranial fluid dynamics, and neural metabolism. Neurology, 32(2):A122, 1982.

Roe, C.R., O'Tuama, L.A., Kim, C.S., and Mann, J.D.: A possible role for omega and

beta oxidation in controlling intracranial pressure. Pediatric Research, 16:340A, 1982.

Kim, C.S., O'Tuama, L.A., Mann, J.D., and Roe, C.R.: Impaired transport of organic

acids by choroid plexus: A potential factor in Reye's encephalopathy. Pediatric Research, 16:336A, 1982.


O'Tuama, L.A., Bohan, T., Kim, C.S., Mann, J. D., Roe, C.R., Johnson, R.N. and

Sutton, C.: Effects of adrenergic agonist on choroid plexus organic acid transport. Society for Neuroscience Abstracts, 8:847, 1982.

Kim, C.S., O'Tuama, L.A., Roe, C.R. and Mann,, J.D.: The effect of octanoic acid on

the uptake of 5-hydroxyindo-leacetic acid by rabbit choroid plexus. Society for Neuroscience Abstracts, 8:848, 1982.

Charlton, J.D., Pederson, N.E., Johnson, R.N. and Mann, J.D.: Cerebrospinal fluid

dynamics in the rat: Analysis of steady-state responses to sinusoidal input. Society for Neuroscience Abstracts, 8:848, 1982.

Mann, J.D., Charlton, J.D., Pederson, N.E. and Johnson, R.N.: In utero exposure to lead

acetate in the rat: Associated impairment of cerebrospinal fluid dynamics in early post-natal development. Society for Neuroscience Abstracts, 8:183, 1982.

Kim C.S., Roe, C.R., Mann, J.D., and Breese, G.R.: The effects of octanoic acid on

dopamine, serotonin and their metabolites in the caudate nucleus and hypothalmus. Society for Neuroscience Abstracts, 11:1263, 1985.

Abashian, S., Lundeen, T.F., Mann, J.D., Toomey, T.C.: Drug utilization in chronic

pain patients. Proceedings of the International Association for Dental Research Meeting, Montreal, Quebec, Canada, March, 1988.

George, J.M., Lundeen, T.F., Toomey, T.C., Mann, J.D., and Abashian, S.: Activity

levels in oral-facial pain patients. Proceedings of the International Association for Dental Research Meeting, Montreal, Quebec, Canada, March, 1988.

Toomey, T.C., Lundeen, T.F., Mann, J.D., and Abashian, S.: Illness behavior

questionnaire: Factor-structure replication and relation to pain. Proceedings of the International Association for Dental Research Meeting, Montreal, Quebec, Canada, March, 1988.

Toomey, T.C., Lundeen, T.F., Mann, J.D. and Abashian, S.W.: The Pain Locus of

Control Scale: A comparison of chronic pain patients and normals. Proceedings of the Canadian Pain Sociaety and the American Pain Society 1: 54, 1988.

Finkel, A.G., Mann, J.D., and McNutt, R. A.: A thirty-eight year old female with a

headache: Case for formal decision analysis. Neurology, 40 (Suppl 1): 353, 1990.

Toomey, T.C., Mann, J.D., Abashian, S., and Lundeen, T.F.: Description of a brief scale

to measure functional impairment in chronic pain patients. Pain, Supplement 5: 303, 1990.

Abashian, S., Mann, J.D. and Toomey, T.C.: Satisfaction with health care delivery in

patients with chronic pain. The Clinical Journal of Pain 7: 53, 1991.


Lundeen, T.F., Forssell, H., and Mann, J.D.: Pain and psychological distress in TMD. The Clinical Journal of Pain 7: 46-47, 1991. Toomey, T.C., Mann, J.D., Abashian, S., and Lundeen, T.: Spatial distribution of pain

aas a clinically useful assessment variable. The Clinical Journal of Pain 7: A51, 1991.

Cheshire, W.P. and Mann, J.D.: Harlequin syndrome in migraine. Neurology 41 (Suppl.

1): 309, 1991. Toomey, T.C., Mann, J.D., Abashian, S., and Thompson-Pope, S.: Relationship between

perceived self-control of pain, pain description and functioning. Annals of Behavioral Medicine 13: 279, 1991.

Cheshire, W.P. and Mann, J.D.: Vertebrobasilar insufficiency induced by head turning

and confirmed by transcranial doppler ultrasonography. Neurology 42 (Suppl 3): 453, 1992.

Toomey, T.C, Mann, J.D. and Abashian, S. Sexual and physical abuse in patients with

chronic pain: Relationship to pain description, location and control attribution. Psychosomatic Medicine 55: 106, 1993.

Finkel, A.G., Howard, J.F. and Mann, J.D.: Successful treatment of headache related to

intravenous immunoglobulin (IVIG) with anti-migraine medications: A case report. Neurology 44 (Suppl. 2): A200, 1994.

Toomey, T.C., Seville, J.L., Holzberg, A.D., Abashian, S.A. and Mann, J.D. The

relationship of sexual/physical abuse to pain description, coping and psychological distress. Psychosomatic Medicine 56: 170, 1994.

Toomey, T.C., Mann, J.D., Abashian, S.W., Carnrike, C.C.M. and Hernandez, J.T. Pain

locus of control scores in chronic pain patients and medical clinic patients with and without pain. Annals of Behavioral Medicine 16: 264, 1994.

Finkel, A.G., Robertson, K.R., Bass, M. and Mann, J.D.: Headache and abuse in

neurologic practice. Headache 34: 306, 1994. Finkel, A.G., Howard, J.F. and Mann, J.D.: Headache related to intrvenous

immunoglobulin (IVIG): A case report and literature review. Cephalalgia 15, Suppl 14:76, 1995.

Steege, J.F., Shortliffe, E.A., Abashian,S.W., Finkel, A.G., Mann, J.D. and Toomey,

T.C. Pain location and psychological distress: Comparison of SCL-90R scales among patients with pelvic pain, headache and low back pain. Abstracts of the American Pain Society Annual Meeting, Los Angeles, California 1995

Finkel, A.G., Dogra, S., Blau, W.F., Abashian, S.W. and Mann, J.D. Gabapentin: A

new therapy for the treatment of chronic pain. Abstracts of the American Pain Society Annual Meeting, Los Angeles, California 1995.

Toomey, T.C., Klocek, J.W., Abashian, S.W., Finkel, A.G. and Mann, J.D. Age and


chronic pain: A comparison of older and younger patients on measures of pain description and psychological distress. Abstracts of the American Pain Society Annual Meeting, Los Angeles, California 1995

Dalton, J.A., Carlson, J., Johnston, C.J., Blau, W.S., Mann, J.D. and Bernard, S.A. Pain

management issues: The cost of medication in a rural setting. Abstracts of the American Pain Society Annual Meeting, Los Angeles, California 1995

Finkel, A.G., Taylor, W.F., Toomey, T., Anderson, A.C. and Mann, J.D. Methadone

treatment for chronic non-malignant pain: Two year follow up. Abstracts of the American Pain Society, 15th Annual Meeting, 1998.

Watson, DB, Kahn KA, Finkel A, Mann D, Robertson KR, Vaughn BV. Sleep complaints in patients with headache. Sleep, Suppl A, 376, 2002. Watson DB, Vaughn BV, Kahn KA, Mann JD, Finkel AG. Polysomnography in patients

with migraine headache. Headache 43: 540, 2003. Gilani A, Robertson K, Lindzen E, Mann, JD. Prevalence of comorbid autoimmune

disease in a cohort of 66 multiple sclerosis ambulatory clinic patients. Neurology 62 (Suppl 5): A224 – A225, 2004.

Kawata, AD, Coeytaux RR, Chao R, Mann JD, Kahn K, Finkel AG. Psychometric

properties of the HIT-6 among patients in a headache specialty practice. Headache 44: 515, 2004.

Coeytaux RR, Kaufman JS, Chen W, Kaptchuk TJ, and Mann JD. Acupuncture as an

adjunct to medical management for chronic daily headache: A randomized clinical

trial. Abstracts of the 11th Annual Society for Acupuncture Research Symposium. San Francisco, California, October 1 –3 , 2004.

Calhoun A, Ford S, Finkel A, Kahn K, Mann JD. Improving seep hygiene benefits

chronic migraine. Headache 45: 780, 2006. Fisher K, Ford S, Calhoun A, Mann JD and Finkel AG. Characteristics of frequent callers

to a headache specialty clinic. Headache (In Press) 2008 Christopher E. Ramsden, John D. Mann, Keturah R. Faurot, Chanee Lynch, Syed Taha

Imam, Rebecca Coble, Beth MacIntosh, Joseph R. Hibbeln, James Loewke, Sunyata Smith, Chirayath Suchindran, Susan A. Gaylord. Low omega-6 and low omega-6 plus high omega-3 diets for the treatment of chronic daily headaches. Poster Presentation at the International Society of Fatty Acids and Lipids (ISSFAL), Maastricht, Netherlands, May 30, 2010. Abstract Published in Proceedings of ISSFAL, In Press.:


Zamora, D., Xun, P., Liu, K., Morris, S., Jacobs, D.R., Mann, J.D., and He, K. 2011.

Toenail chromium and incident metabolic syndrome among American young adults. Poster presentation, American Heart Association Nutrition, Physical Activity and Metabolism Scientific Sessions, Atlanta, Georgia, March 2011. Abstract in Circulation.


PRESENTATIONS Johns, T.R., Mann, J.D., Campa, J.F., and Joseph, B.S.; Long-term administration of

corticosteroids in myasthenia gravis. American Academy of Neurology. April 28, 1972, St. Louis, Missouri.

Mann, J.D., Butler, A.B., and Bass, N.H.: Identification of the major site of

cerebrospinal fluid efflux in the albino rat. Society for Neuroscience, Fifth Annual Meeting. November 3, 1975, New York, New York.

Mann, J.D., Johns, T.R., Campa, J.F., and Muller, A.H.: Long-term prednisone followed

by thymectomy in myasthenia gravis. Conference on Myasthenia Gravis, New York Academy of Sciences. May 31, 1975, New York, New York.

Mann, J.D., Johns, T.R., Campa, J.F., and Muller, A.H.: Long-term administration of

corticosteroids in myasthenia gravis. American Neurological Association Meeting. June 2, 1975, New York, New York.

Maffeo, C.J., Mann, J.D.. Butler, A.B., Bass, N.H., and Johnson, R.N.: Constant-flow

perfusion of the cerebrospinal fluid system of the rat, dog and man: A mathematical model. Fourth Annual New England Bioengineering Conference. May 7, 1976, New Haven, Connecticut.

Mann, J.D., Maffeo, C.J., Rosenthal, J.D., Johnson, R.N., Butler, A.B., and Bass, N.H.:

Regulation of intracranial pressure in rat, dog and man: Manometric assessment of cerebrospinal fluid dynamics using a constant-flow perfusion system. American Neurological Association. June 14, 1976, San Francisco, California.

Butler, A.B., Mann, J.D., Maffeo, C.J., Johnson, R.N., Bass, N.H.: Regulation of

intracranial pressure in rat, dog, and man: Manometric assessment of CSF dynamics using a constant-flow perfusion system. Congress of Neurological Surgeons. October 1976, New Orleans, Louisiana.

Mann, J.D., Young, E.A., and Bass, N.H.: Role of the blood-cerebrospinal fluid barrier

in the development of tolerance of the respiratory depressant effects of morphine. Society for Neuroscience, Seventh Annual Meeting. November, 1977, Anaheim, California.

Cookson, S.L., Mann, J.D., Kim, C.S., Gatzy, J.T., and O'Tuama, L.A.: The effects of

lead intoxication on the brain uptake of calcium in adult albino rabbits. Society for Neuroscience, Seventh Annual Meeting. November 1977, Anaheim, California.

O'Tuama, L.A., Kim, C.S., Mann, J.D., and Gatzy, J.T.: Increased permeability of

periventricular tissues in lead poisoning. Seventh Annual Meeting, Society for Neuroscience. November 1977, Anaheim, California.


Mann, J.D., Bass, N.H.: Role of the cerebrospinal fluid in the respiratory depressant effects of morphine and enkephalin. American Society for Neurochemistry, Annual Meeting. March, 1978, Washington, DC.

Butler, A.B., Mann, J.D., Bass, N.H., and Jane, J.A.: Cerebrospinal fluid transport

mechanisms in the arachnoid villus. American Association of Neurological Surgeons Annual Meeting. April 1978, New Orleans, Louisiana.

Maffeo, C.J., Van Landingham, K.E., Mann, J.D.,

Butler, A.B., Bass, N.H., and Johnson, R.N.: Model predicted parameters critical to intracranial pressure regulation. Ninth Annual Conference on Modeling and Simulation. April 27, 1978, Pittsburgh, Pennsylvania.

Szyper, M.D. and Mann, J.D.: Anorexia nervosa as an interictal symptom of partial

complex seuzures. American Academy of Neurology. April 1978, Los Angeles, California.

Mann, E.S., Cookson, S.L., and Mann, J.D.: Comparative effects of ketamine

hydrochloride and pentobarbital on cerebrospinal fluid formation rate and outflow resistance in the rat. American Society of Anesthesiologists, Annual Meeting. October 24, 1978, Chicago, Illinois.

Kim, D.S., O'Tuama, L.A.,. Cookson, S.L., and Mann, J.D.: The effects of lead

poisoning on calcium transport by the brain in 30-day old albino rabbits. Society for Neuroscience, Eighth Annual Meeting. November, 1978, St. Louis, Missouri.

Cookson, S.L. and Mann, J.D.: Reversal and prevention of acute morphine induced

catalepsy by phenytoin in naive rats. Society for Neuroscience, Eighth Annual Meeting. November, 1978, St. Louis, Missouri.

Maffeo, C.J., Van Landingham, K.E., Mann, J.D.,

Butler, A.B., Bass, N.H., and Johnson R.N.: Model predicted parameters critical to intracranial pressure regulation. Tenth Annual Conference on Modeling and Simulation. April, 1979, Pittsburgh, Pennsylvania.

Bass, N.H., Maffeo, C.J., Van Landingham, K., Mann, J.D., Kasarskis, E.J., Butler,

A.B., and Johnson, R.N.: Mathematical modeling of mechanisms controlling the third circulation: Its clinical importance in health and disease. Tenth Annual Conference on Modeling and Simulation. April, 1979, Pittsburgh, Pennsylvania.

Mann, J.D., Johnson, R.N., Butler, A.B., and Bass, N.H.: Impairment of cerebrospinal

fluid circulatory dynamics in pseudotumor cerebri and response to steroid treatment. American Academy of Neurology. April, 1979, Chicago, Illinois.

Johnson, R.N., Maffeo, C.J., Lasarskis, E.J., Mann, J.D., Butler, A.B., and Bass, N.H.:

System regulation of intracranial hypertension: A model technique to assess abnormal mechanisms and response to therapy. American Academy of Neurology. April, 1979, Chicago, Illinois.


Mann, J.D., Cookson, S.L., and Mann, E.S.: Differential effects of pentobarbital, ketamine and enflurane on cerebrospinal fluid outflow resistance and production rate in the rat. Fourth International Symposium on Intracranial Pressure. June 13, 1979, Williamsburg, Virginia.

Mann, E.S., Cookson, S.L., and Mann, J.D.: Effects of enflurane and halothane on CSF

dynamics in the rat. American Society of Anesthesiologists, Annual Meeting. October, 1979, San Francisco, California.

Mann, J.D., Cookson, S.L., and Mann., E.S.: Comparative effects of pentobarbital,

ketamine, enflurane and halothane on cerebrospinal fluid dynamics in the rat. Society for Neuroscience, Ninth Annual Meeting, November, 1979, Atlanta, Georgia.

Mann, J.D.: Headache as an index of toxicity: Facts and fictions. Occupational

Toxicology for the Physician. October 29, 1979, University of North Carolina, Chapel Hill, NC.

Mann, J.D. and Cookson, S.L.: Impaired cerebrospinal fluid absorption in the

developing rabbit following exposure to lead. Society for Neuroscience, Tenth Annual Meeting. November, 1980, Cincinnati, Ohio.

Bhagat, A., Mann, J.D., Furlow, T.W., Traurig, H., and

Bass, N.H.: Digoxin-induced cardiac arrhythmia: Digitalization of receptor sites in brainstem. Annual Meeting of the American Neurological Association. September, 1980, Boston, Massachusetts.

Charlton, J.D., Cookson, S.L., Pederson, N.E.,

Johnson, R.N., and Mann, J.D.: The effect of lead on CSF transport in the isolated superior sagittal sinus of the dog. Society for Neuroscience, Eleventh Annual Meeting. October, 1981, Los Angeles, California.

O'Tuama, L.A., Mann, J.D., Kim, C.S., Roe, C.R.,

Pederson, N.E., and Sutton, C.: A new model for Reye's encephalopathy. American Academy of Neurology, Annual Meeting. April, 1982, Washington, DC.

Kim, C.S., O'Tuama, L.A., Mann, J.D., and Roe, C.R.: Impaired transport of organic

acids by choroid plexus: A potential factor in Reye's encephalopathy. Society for Pediatric Research Annual Meeting. May, 1982, Washington, DC.

O'Tuama, L.A., Bohan, T., Kim, C.S., Mann, J.D., Roe, C.R., Johnson, R.N., and

Sutton, C.: Effects of adrenergic agonist on choroid plexus organic acid transport. Society for Neuroscience, Twelfth Annual Meeting. October, 1982, Minneapolis, Minnesota.

Kim, C.S., O'Tuama, L.A., Roe, C.R., and Mann, J.D.: The effect of octanoic acid on

the uptake of 5-hydroxyindoleacetic acid by rabbit choroid plexus. Society for Neuroscience, Twelfth Annual Meeting. October, 1982, Minneapolis, Minnesota.


Charlton, J.D., Pederson, N.E., Johnson, R.N., and

Mann, J.D.: Cerebrospinal fluid dynamics in the rat: Analysis of steady-state responses to sinusoidal input. Society for Neuroscience, Twelfth Annual Meeting. October, 1982, Minneapolis, Minnesota.

Mann, J.D., Charlton, J.D., Pederson, N.E., and

Johnson, R.N.: In utero exposure to lead acetate in the rat: Associated impairment of cerebrospinal fluid dynamics in early post-natal development. Society for Neuroscience. October, 1982, Minneapolis, Minnesota.

Mann, J.D., Charlton, J.D., Pederson, N.E., Cookson, S.L., and Johnson, R.N.:

Reduction in cerebrospinal fluid transport mediated by lead acitate in the in vitro superior sagital sinus of the dog. The Sixth International Symposium on Intracranial Pressure. June, 1985, Glasgow, Scotland.

Kim C.S., Roe, C.R., Mann, J.D., and Breese, G.R.: The effects of octanoic acid on

dopamine, serotonin and their metabolites in the caudate nucleus and hypothalmus. Society for Neuroscience, Fifteenth Annual Meeting. October, 1985, Dallas, Texas.

Lundeen, T.F. and Mann, J.D.: The role of the clinical pain conference in a

multidisciplinary pain management program. Second International Symposium, The Pain Clinic. October, 1986 Lille, France.

George, J.M., Lundeen, T.F., Toomey, T.C., Mann, J.D., and Abashian, S.: Activity

levels in oral-facial pain patients. International Association for Dental Research. March, 1988, Montreal, Quebec, Canada.

Toomey, T.C., Lundeen, T.F., Mann, J.D., and Abashian, S.: Illness behavior

questionnaire: Factor-structure replication and relation to pain. International Association for Dental Research. March, 1988, Montreal, Quebec, Canada.

Toomey, T.C., Wingfield, M., Mann, J.D., and Abashian, S.: The effects of quality of

pain on perceived ability to control pain. Presented at "The Pain Clinic," Third International Symposium. September, 1988, Florence, Italy.

Toomey, T.C., Lundeen, T.F., Mann, J.D., and Abashian, S.: The Pain Locus of Control

Scale: A comparison of chronic pain patients and normals. American/Canadian Pain Society Meeting, November, 1988, Toronto, Canada.

Lundeen, T.F., Toomey, T.C., Mann, J.D., and Abashian, S.: Activity levels in oral-

facial pain patients. American Association for Dental Research, March, 1989, San Francisco, CA.

Toomey, T.C., Lundeen, T.F., Mann, J.D., and Abashian, S.: Pain locus of control: A

comparison of two patient groups. American Association for Dental Research, March, 1989, San Francisco, CA.


Toomey, T.C., Mann, J.D., Abashian, S., and Lundeen, T.F.: Relationship of locus of control to measures of pain and reported behavioral functioning. Eigth Annual Meeting, American Pain Society, October, 1989, Phoenix, Arizona.

Finkel, A.G., Mann, J.D., and McNutt, R.: A thirty-eight year old female with a

headache: Case for formal decision analysis. The American Academy of Neurology 42nd Annual Meeting, April, 1990, Miami Beach, Florida.

Toomey, T.C., Mann, J.D., Abashian, S., Thompson-Pope, S.: Description of a brief

scale to measure functional impairment in chronic pain patients. The Sixth World Congress on Pain of the Internatinal Association for the Study of Pain, April, 1990, Adelaide, Australia.

Abashian, S., Mann, J.D. and Toomey, T.C.: Satisfaction with health care delivery in

patients with chronic pain. Ninth Annual Scientific Meeting, American Pain Society, October, 1990, St. Louis, Missouri.

Toomey, T.C., Mann, J.D. and Abashian, S.: Spatial distribution of pain as a clinically

useful assessment variable. Ninth Annual Scientific Meeting, American Pain Society, October, 1990, St. Louis, Missouri.

Lundeen, T.F., Forssell H. and Mann, J. D.: Pain and psychological distress in

temporomandibular disorders. Ninth Annual Scientific Meeting, American Pain Society, October, 1990, St.

Louis, Missouri. Cheshire, W.P. and Mann, J.D.: Harlequin syndrome in migraine. The American

Academy of Neurology, 43rd Annual Meeting, April, 1991, Boston, Massachusetts.

Toomey, T.C., Abashian, S., Hernandez, J.T., Mann, J.D., and Wingfield, M.

Psychometric characteristics of a brief measure of pain related functional impairment. American Pain Society Annual Meeting, November, 1991, New Orleans, Louisiana

Abashian, S., Toomey, T.C., Wingfield, W., Cheshire, W.P., Finkel, A., and Mann, J. D.

Satisfaction with health care delivery: A follow-up study in patients with chronic benign pain. American Pain Society Annual Meeting, November, 1991, New Orleans, Louisiana

Cheshire, W.P. and Mann, J.D. Vertebrobasilar insufficiency induced by head turning

and confirmed by transcranial doppler ultrasonography. American Academy of Neurology Annual Meeting, May, 1991, San Diego, California

Abashian, S., Toomey, T.C., Cheshire, W.P., Wingfield, M.S.

and Mann, J.D. Limited pain program interventions: Beneficial effects on pain intensity, activity level and suffering. American Pain Society Annual Meeting,

October, 1992, San Diego, California Toomey, T.C., Abashian, S., Cheshire, W.P., Hernandez, J.T.and Mann, J.D.


Pain locus of control scores in chronic pain patients and medical clinic patients with and without pain. American Pain Society Annual Meeting,

October, 1992, San Diego, California Toomey, T.C., Seville, J.L., Abashian, S.W., Finkel, A.G.and Mann, J.D.: Circumstances

of chronIC pain onset: Relationship to pain description, coping and psychologic distress. American Pain Society Annual Meeting, October, 1993, Orlando, Florida

Finkel, A.G., Howard, J.F. and Mann, J.D.: Successful treatment of headache related to

intravenous immunoglobulin (IVIG) with anti-migraine medications: A case report. American Academy of Neurology Annual Meeting, May, 1994, Washington, D.C.

Finkel, A.G., Toomey, T.C., Abashian, S.W. and Mann, J.D.:Methadone in chronic non-

malignant pain: A retrospective study. American Pain Society Annual Meeting, November, 1994, Miami Beach Florida Finkel, A.G., Howard, J.F. and Mann, J.D.: Headache related to intrvenous

immunoglobulin (IVIG): A case report and literature review. Seventh International Headache Congress, September, 1995, Toronto, Canada

Steege, J.F., Shortliffe, E.A., Abashian,S.W., Finkel, A.G., Mann, J.D. and Toomey,

T.C. Pain location and psychological distress: Comparison of SCL-90R scales among patients with pelvic pain, headache and low back pain. American Pain Society Annual Meeting, November, 1995, Los Angeles, California

Finkel, A.G., Dogra, S., Blau, W.F., Abashian, S.W. and Mann, J.D. Gabapentin: A new

therapy for the treatment of chronic pain. American Pain Society Annual Meeting, November, 1995, Los Angeles, California

Toomey, T.C., Klocek, J.W., Abashian, S.W., Finkel, A.G., and Mann, J.D. Age

and chronic pain: A comparison of older and youndeer patients on measures of pain description and psychological distress. American Pain Society Annual Meeting, November, 1995, Los Angeles, California

Dalton, J.A., Carlson, J., Johnston, C.J., Blau, W.S., Mann, J.D. and Bernard,

S.A. Pain management issues: The cost of medication in a rural setting. American Pain Society Annual Meeting, November, 1995, Los Angeles, California.

Mann, J.D. The Role of Anticonvulsants in Pain Management. James N.

Hayward Symposium, 1997, Chapel Hill, N.C. Mann, J.D. Emerging Therapies for the Treatment of Headaches: Magnesium

and Botulinum Toxin. North Carolina Neurological Society, Annual Meeting, 1999, Greensboro, N.C.

Mann, J.D. Chronic Pain Syndromes: Integrating Alternative and

Conventional Approaches. Fourth Annual Wake AHEC


Alternative and Complementary Therapies Symposium, 1999, Raleigh, N.C.

Mann, J.D. Complementary Therapies in Migraine Management. Principles

Headache Management in the New Millennium. 1999 Chapel Hill, N.C. Watson DB, Vaughn BV, Kahn KA, Mann D, Finkel AG. Polysomnograthy in patients

with migraine headache. 45th Annual Scientific Meeting, American Headache Society, June 2003, Chicago, Illinois. (Winner AHS Travel Award.)

Kawata, A., Coeytaux, R., Chao R, Mann JD, Kahn K, Finkel A. Psychometric

properties of the HIT-6 among patients who seek headache specialty care. American Headache Society Annual Meeting, Seattle, Washington 2004.

Gilani A, Robertson K, Lindzen E, Mann, JD. Prevalence of comorbid autoimmune

disease in a cohort of 66 multiple sclerosis ambulatory clinic patients. American Academy of Neurology Annual Meeting, San Francisco, California, April 24 – May 1, 2004.

Kawata AK, Coeytaus RR, Chao R, Mann JD, Kahn K, Finkel AG. Psychometric

properties of the HIT-6 among patients in a headache specialty practice. American Headache Society, 46th Annual Meeting, Vancouver, British Columbia, June 10 –13, 2004.

Coeytaux RR, Kaufman JS, Chen W, Kaptchuk TJ, and Mann JD. Acupuncture as an

adjunct to medical management for chronic daily headache: A randomized clinical

trial. 11th Annual Society for Acupuncture Research Symposium. San Francisco, California, October 1 –3 , 2004.

Gaylord S, Mann JD. Integrative medicine: A panel discussion of current issues. The

Third North Carolina Natural Products Association Conference: “Cultivating the New Wellness-Driven Economy in North Carolina. Boone, North Carolina, November 17-18, 2006.

Calhoun AH, Ford S, Finkel AG, Kahn KA, Mann JD: Improving sleep hygiene benefits

chronic migraine. National Headache Foundation Research Summit, Rancho Mirage, California, February 15-18, 2007.

Fisher KG, Ford S, Calhoun AH, Mann JD, Finkel AG: Can you hear me now? Patient

characteristics associated with frequent phone calls to a headache specialty clinic. American Headache Society Annual Meeting, Chicago, Illinois, June 7-10, 2007.


Gaylord, S., Palsson, O., Faurot, K., Garland, E., Coble, B., Mann, D., & Whitehead, B..

Dispositional mindfulness is associated with psychological symptoms accompying irritable bowel syndrome. Biopsychosocial Gastrointestinal Research Day 2008, University of North Carolina, Chapel Hill, NC. October 4, 2008.

Gaylord, S., Palsson, O., Faurot, K., Garland, E., Coble, B., Mann, D., & Whitehead, B..

Dispositional mindfulness is associated with psychological symptoms accompanying irritable bowel syndrome. North American Research Conference on Complementary & Integrative Medicine, Minneapolis, MN. May 12, 2009.

Ramsden CE, Mann JD, Faurot KF, Lynch C, Imam ST, Coble R, MacIntosh B,

Hibbeln JR, s Loewke J, Smith S, Suchindran C, Gaylord SA. Low omega-6 and low omega-6 plus high omega-3 diets for the treatment of chronic daily headaches. International Society of Fatty Acids and Lipids (ISSFAL), Maastricht, Netherlands, May 30, 2010

Gaylord, S.A., Palsson, O., Garland, E.L., Faurot, K., Mann, J.D. & Whitehead, B.W. .

Therapeutic impact of mindfulness meditation on irritable bowel syndrome: Results of a randomized controlled trial. Digestive Disease Week 2011, Chicago, Illinois. May 9, 2011.

Garland, E.L., Gaylord, S.A., Palsson, O., Faurot, K., Mann, J.D., & Whitehead, W.

Mindfulness training targets cognitive and affective mechanisms to reduce illness severity and improve quality of life among women with irritable bowel syndrome. Society for Social Work and Research 2011, Tampa, Florida. January 14, 2011.

Zamora, D., Xun, P., Liu, K., Morris, S., Jacobs, D.R., Mann, J.D., and He, K. Toenail chromium and incident metabolic syndrome among American young adults. Poster presentation, American Heart Association Nutrition, Physical Activity and Metabolism Scientific Sessions, Atlanta, Georgia, March 2011. (Abstract in Circulation)

Garland EL, Gaylord SA, Palsson O, Faurot K, Mann JD.

Mindfulness training ameliorates IBS by promoting non-reactivity and reduced affective processing of pain sensation. Center for Mindfulness, 10th Annual International Scientific Conference. Investigating and Integrating Mindfulness in Medicine, Health Care and Society. Norwood, Massachusetts, March 28-April 1, 2012.


Faurot K, Zamora D, Young LA, Gardiner P, Gaylord S, Mann JD.

Factors related to botanical and specialty supplement use among Hispanics/Latinos in the 2007 National Health Interview Survey. 2012 International Research Congress on Integrative Medicine and Health. Portland, Oregon, May 15-18, 2012.

Mann JD, Gaylord SA, Faurot KR, Suchindran C, Coeytaux R, Coble R, Wilkinson L,

Curtis P. Craniosacral therapy for migraine – A feasibility study. 2012 International Research Congress on Integrative Medicine and Health. Portland, Oregon, May 15-18, 2012.

Smith S, Ramsden CE, Gaylord SA, Faurot KR, Lynch C, and Mann JD.

Effects of a low omega-6 and high omega-3 diet on inflammatory gene expression in patients with chronic daily headache. International Research Congress on Integrative Medicine and Health. Portland, Oregon, May 15-18, 2012.

Smith S, Ramsden CE, Gaylord SA, and Mann JD.

Effects of a low omega-6, high omega-3 diet on inflammatory gene expression in chronic daily headache. Physical Medicine and Rehabilitation Research Day. Chapel Hill, North Carolina. June 1, 2012

Zamora D, Ramsden CE, Mann JD. Dietary interventions for chronic daily headache.

Physical Medicine and Rehabilitation Research Day. Chapel Hill, North Carolina. June 1, 2012

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