joel bernstein november - bguin.bgu.ac.il/teva/chem/staffcv/joelbernstein.pdf · 1 joel bernstein...

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Joel Bernstein November 2011

CURRICULUM VITAE

PERSONAL DETAILS

Born September 12, 1941; Cleveland, Ohio

Widowed, two children

Current professional affiliation: Faculty of Natural Sciences, New York University Abu Dhabi

Email: [email protected]

Previous address (Emeritus): Department of Chemistry, Ben-Gurion University

Beer Sheva, Israel 84105 email: yoel@ bgu.ac.il

Home address: 8 Jabotinsky St., Apt. 11, Tel Aviv, Israel;

tel: +972 3 529 8101; fax: +972 3 529 0582; cell: +972 507 959 828

EDUCATION

Degree Institution Years

B.A. (Chemistry) Cornell University 1958-1962

M.Sc. Yale University 1962-1964

Ph.D. Yale University 1964-1967

Advisor: Basil G. Anex

Thesis title: "Spectral Properties of trans-Azobenzene and trans-Stilbene"

EMPLOYMENT HISTORY

Institution Rank Years

Cornell University Teaching assistant 1962

Weizmann Institute of Science Summer student 1962

Yale University Teaching assistant 1962-66

Univ. of California (Los Angeles) Postdoctoral 1967-69

Weizmann Institute of Science Postdoctoral 1969-71

Ben-Gurion University Lecturer 1971-73

Ben-Gurion University Senior Lecturer (tenure) 1973-79

University of Illinois (Urbana) Visiting Scientist 1977-78

Ben-Gurion University Associate Professor 1979-88

Cornell University Visiting Professor 1983-84

University of Minnesota Visiting Professor 1988-89

Ben-Gurion University Professor 1988-

University of Barcelona Visiting Professor 7/97-9/97

Cambridge Crystallographic Data Centre Visiting Fellow 9/97-9/98

Rand Afrikaans University Visiting Professor 8/99-9/99

University of Bologna

Institute of Advanced Study Visiting Professor 3/05-4/05; 07/08;

07/09; 07/10

University of Barcelona Visiting Professor 5/05-6/05

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University of Johannesburg Visiting Professor 07/05-08/05

Ben-Gurion University Barry and Carol Kaye Professor

of Applied Science 04/08- 06/11

Australian National University Craig Visiting Professor 10/09-11/09

University of Western Australia Gledden Senior Fellow 11/09-01/10

Osaka University Global Center of Excellence

Professor 03/10

University of Western Australia Professor at Large 2010-2011

New York University Abu Dhabi Professor 05/2010 -

RESEARCH INTERESTS

Organic solid state chemistry, chemical crystallography, polymorphism, hydrogen bonding, graph sets,

structure-property relations in organic solids and pharmaceuticals.

POSITIONS IN ACADEMIC ADMINISTRATION WITHIN THE UNIVERSITY

Undergraduate Studies Committee, 1971-1977, 1986-88.

Undergraduate Advisor, 1971- .

Director of Undergraduate Studies, 1973-1975.

Graduate Studies Committee, 1971-1973; 1978-1986 .

Director of Graduate Studies, 1978-1980.

University Computer Policy Committee, 1971-1973; 1976-1977.

University Computer Evaluation and Selection Committee, 1972-1977.

University Athletics Committee, 1975-1977.

Faculty of Natural Sciences ad hoc Committee for Implementation of the Credit System of Studies,

1974-1975.

Department of Chemistry Executive Committee, 1985-88, 1994-

Rector's Select Committee on Undergraduate Curriculum and Education, 1986-87.

Chairman, Graduate Studies Committee, Faculty of Natural Sciences, 1987-88.

Vice-chairman, Department of Chemistry, 1987-88.

Dozor Visiting Professors Fund Committee, 1989-, Chairman, 1991-1995

Steering Committee, Board of Governors, 1990-1992, 1993-1997

University Supreme Committee on Appointments and Promotion, 1993-1997

Chairman, University Committee to Establish a Program of Studies in Hotel, Hospitality

and Tourism Management, 1992-1994

Department of Chemistry Executive Committee, 2005-2007

Faculty of Natural Sciences Promotion and Tenure Committee, 2006-2008.

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PROFESSIONAL FUNCTIONS OUTSIDE THE UNIVERSITY

President, Israel Crystallographic Society, 1979-1983, 1993-1997

Israeli representative to European Crystallographic Committee, 1980-1982, 1992, 1993, 1994.

Israeli representative to International Union of Crystallography XII Congress, 1981.

Chairman, Organizing Committee, Seventh European Crystallography Meeting, Jerusalem, August,

1982.

Member, Selection Committee, Gerhard Schmidt Memorial Prize, 1984-87.

Israeli Chairman, Organizing Committee for Joint Israeli-Italian Meeting on "The Influence of Steric

and Electronic Effects on Molecular Crystalline Structures", Florence, Italy, 1987.

Co-Chairman, Second Midwest Meeting on Organic Solid State Chemistry, Minneapolis, 1989.

Chairman, Microsymposium on "Crystal Engineering", XV Congress, International Union of

Crystallography, Bordeaux, July, 1990.

Member, Joint Committee on Powder Diffraction Standards-International Centre for Diffraction Data,

1990-.

Member, Steering Committee for Israeli National Center on Protein Crystallography, Hebrew

University, Jerusalem, 1990-1994 .

Member, International Program Committee, VIIIth Symposium on Organic Crystal Chemistry,

Rydzyna, Poland, 1992.

Chairman, Organizing Committee, Second Joint Israeli-Italian Meeting on "The Influence of

Steric and Electronic Effects on Molecular Crystalline Structures", held in Israel, February, 1992.

Member, Program Committee, XI International Conference on the Chemistry of the Organic Solid State,

Jerusalem, Israel, July, 1993.

Member, International Advisory Committee, Third International Conference on Crystal Growth of

Materials,Washington, D.C., August, 1995.

Israeli Co-Chairman, Organizing Committee, Joint Italian-Israeli Conference on Crystal Structure

and Molecular Recognition", held in Ferarra, Italy, February, 1996.

Vice President, European Crystallographic Committee, 1994-2000

Co-Chairman, Microsymposium on "Organic Materials", XVII Congress, International Union of

Crystallography, Seattle, August, 1996.

Chairman, Program Committee, Xth Symposium on Organic Crystal Chemistry (OCC-97) held

in Rydzyna, Poland, August, 1997.

External Ph.D. Examiner, University of Copenahgen, Denmark, February, 1997.

Co-Chairman, Microsymposium on “Polymorphism”, 17th European Crystallographic Meeting,

Lisbon, Portugal, August, 1997.

Chairnan, Microsymposium on “Polymorphism and Isomorphism”, XVIII Congress and General

Assembly of the International Union of Crystallography, Glasgow, Scotland, August, 1999.

Member, Organizing Committee, PhandTA4 – 4th

Symposium/Workshop on Pharmacy and Thermal

Analysis, Karlsruhe, German, March, 1999.

Chairman, First European Crystallography Prize Committee, 2000.

External Ph.D. Examiner, Technical University of Denmark, Lyngby, Denmark, February, 2000.

Organizer and Chairman, Session on “Crystallization, Polymorphism and Properties of Organic

Crystals”, at the Gordon Research Conference on “Organic Structures and Properties: Extended

Systems”, held at New London, CT, June, 2000.

Member, International Program Committee, 11th

Symposium on Organic Crystal Chemistry, Rydzyna,

Poland, 2001.

Member, International Program Committee, 20th

European Crystallography Meeting, Krakow, Poland,

August, 2001.

Coconvener and Cochairman, European Polymorphism Network, 2001-2004

Chairman, Organizing Committee, XIX Congress and General Assembly of International Union of

Crystallography (IUCr XIX), held in Geneva, Switzerland, August 2002.

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External Ph.D. Examiner, Department of Chemistry, Rand Afrikaans University, Johannesburg, South

Africa, 2003

Chairman, Microsymposium on “Polymorphism and Isomorphism”, XXI European Crystallography

Meeting, Durban, South Africa, August, 2003.

Director, NATO Advanced Study Institute and International School of Crystallography on “Polymorphs

and Solvates” held in Erice, Sicily, June, 2004.

Co-Chairman, Symposium honoring awardees of ACA Fankuchen Prize and Trueblood Prize at the

annual meeting of the American Crystallographic Association, Salt Lake City, July, 2007

Co-Chairman, Microsymposium on “Functional crystallography: tuning molecular behavior” held at the

24th European Crystallographic Meeting, Marrakech, Morocco, August, 2007

Chairman, Poster Prize Committee, 24th European Crystallographic Meeting, Marrakech, Morocco,

August, 2007

Member, International Committee for Frevel Scholarship Awards, International Centre for Diffraction

Data, Newton Center, PA, USA, 2004-

Member, Max Perutz Prize Selection Committee, European Crystallographic Association, 2010.

Member, International Scientific Committee, “Insubria International Summer School on

Crystallographic Techniques for Health and Biosciences” to be held in Como, Italy, June 19-23,

2012.

EDITORIAL BOARDS

Member, Editorial Advisory Board, Israel Journal of Chemistry, 1993 - 2010.

Member, International Editorial Advisory Board, Structural Chemistry, 1993 - .

Member, International Editorial Advisory Board, Zeitschrifft fur Kristallographie, 1997 -2003

Member, International Editorial Advisory Board, Crystal Engineering, 1997 –2003

Member, International Advisory Board, Crystal Engineering Communications, 2000-2002

Topic Editor, Polymorphism and Polytypism, Crystal Growth & Design, 2000-.

Member. Editorial Advisory Board, Journal of Pharmaceutical Sciences, 2011 -

Member, Oxford University Press/International Union of Crystallography Book Series Committee,

2002-.

PROFESSIONAL CONSULTING

Leo Pharmaceuticals Denmark, 2011 -

Cephalon, U.S.A. 2009-

Johnson & Johnson 2008 - 2009

Astra Zeneca, U.K. 2007

Roche, U.S.A. 2007-2009; 2011-

Organon, U.K. and Holland, 2004-2006

sanofi-aventis, U.S.A., U.K., Korea, France and South Africa 2003-

Eli Lilly, U.S.A., 2004; 2007-2008

Chemagis, Israel, 2003

Agan Chemicals, Israel, 2003, 2009

Rechter Gideon, Hungary, 2002-2005

Pfizer Pharmaceuticals, U.S.A., 2001-2003

Warner-Lambert Pharmaceuticals, U.S.A., 2000-2003

TransForm Pharmaceuticals, U.S.A., 2000-2006

Millenium Pharmaceuticals, U.S.A., 1999

Abbott Laboratories, U.S.A., 1997, 2002

SmithKline Beecham, United Kingdom and U.S.A., 1996 - 1998

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Unipharm, Tel Aviv, Israel, 1993-1994.

GlaxoSmithKline, U.S.A, U.K., Australia, Denmark and Canada, 1992-.

Teva Pharmaceuticals, Petah Tikva, Israel, 1991-1995.

3M Company, St. Paul, Minnesota, 1980-84.

Bethlehem Steel Corporation, Bethlehem, Pennsylvania, 1981.

Plantex Pharmaceuticals, Ltd. Netanya, Israel, 1980.

Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel, 1977-80.

COURSES TAUGHT

At Ben-Gurion University:

General Chemistry for chemistry majors and chemical engineers

Introduction to Analytical Chemistry

General and Analytical Chemistry Laboratory

Physical Chemistry Laboratory

Advanced Integrated Laboratory for third year (senior) students, including

conception and preparation of the course.

X-ray Crystallography for graduate students

Solid State Chemistry for graduate students

Molecular Symmetry for graduate students

At Cornell University:

X-ray Crystallography for graduate students (with J. Clardy)

At the University of Minnesota

Organic Solid State Chemistry for graduate students

At New York University Abu Dhabi

Foundations of Science - Chemistry

MEMBERSHIPS IN PROFESSIONAL SOCIETIES

American Chemical Society, 1974- .

Sigma Xi, 1966 -.

American Association for the Advancement of Science, 1967 -; Elected Fellow, 1999.

American Crystallographic Association, 1968 -.

Royal Society of Chemistry (London), 1972 -.

American Physical Society, 1968 -.

Israel Crystallographic Society, 1971 - (President 1979-1983; 1993-1997)

AWARDS, HONORS, RESEARCH FELLOWSHIPS:

National Institutes of Health Predoctoral Fellow, 1963-67

Institute Fellow, Weizmann Institute of Sciences, 1969-71.

BGU - UCLA Exchange Fellow, February, 1983.

Israel - Italy National Council for Research and Development Senior Scientist Exchange Fellow,

March-April, 1983.

Israel - Italy National Council for Research and Development Senior Scientist Exchange Fellow,

June, 1991.

“Iberdrola – Cincia y Technologia: Visiting Professor, University of Barcelona, July-September 1997

Eric Samson Chair, Rand Afrikaans University, August-September, 1999

Fellow, American Association for the Advancement of Science, 1999-

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Fellow, Institute for Advanced Study, University of Bologna, 2005

Fellow, HPC-Europa Transnational Access, University of Barcelona, 2005

Barry and Carol Kaye Endowed Professorship in Applied Science, Ben-Gurion University, 2008-

David P. Craig Visiting Professor, Australian National University, 10/09-11/09

Gledden Visiting Fellowship, University of Western Australia, 11/09 – 01/10

Professor-at-Large, University of Western Australia, 2010-2011

Visiting Lecturer, Global Center for Excellence Program, Osaka University, Osaka, Japan, 2010

SCIENTIFIC PUBLICATIONS (Citations as of January, 2010 in bold italics at end of entry)

Book

J. Bernstein

“Polymorphism in Molecular Crystals”, Oxford University Press, ISBN 0 19 850605, (2002) 410 pages.

(Russian translation edition, 2008) (574)

Chapters in collective volumes

1."Structural Chemistry of Quinones"

J. Bernstein, M.D. Cohen and L. Leiserowitz

A chapter in the book "The Chemistry of Quinones", S. Patai, ed., Wiley Interscience, New York,

1974, pp. 37-110. (96)

2. "Crystal Forces and Molecular Conformation"

J. Bernstein

Chapter in book "X-ray Crystallography and Drug Action: Current Perspectives", A.S. Horn and

C.J. De Ranter, eds., Oxford University Press, New York, 1984, pp. 23-44. (11)

3."Conformational Polymorphism"

J. Bernstein

Chapter 14 in the book "Organic Solid State Chemistry", G. Desiraju, ed., Elsevier, Amsterdam,

1987, pp. 471-518. (173)

4. "Polymorphism in Drug Design and Delivery"

J. Bernstein

In "Computer Assisted Modeling of Receptor-Ligand Interactions: Theoretical Aspects and

Applications to Drug Design", A. Golombek, ed. Alan R. Liss, New York (1989), pp. 203-215. (2)

5. "Polymorphism and the Investigation of Structure-Property Relations in Organic Solids"

J. Bernstein

In "Organic Crystal Chemistry", J.B. Garbarczyk and D. W. Jones, eds. Oxford University Press, Oxford.

1991, pp. 6-26. (9)

6."Effect of Crystal Environment on Molecular Structure"

J. Bernstein

In "Accurate Molecular Structures", A. Domenicano and I. Hargittai , eds. Oxford University Press, Oxford.

1992, pp. 469-497. (40)

7. "The Role of Hydrogen Bonding in Molecular Assemblies"

J. Bernstein, M.C. Etter and L. Leiserowitz

In "Structure Correlations", J.D. Dunitz and H.-B. Bürgi, eds. Volume 2,VCH, Weinheim,

1994, pp. 431-507. (158)

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8. “Structural and Crystallogaphic Aspects of Supramolecular Engineering:

Structure-Property Relations, Polymorphism and Crystal Growth”

J. Bernstein

NATO Advanced Research Workshop on Supramolecular Engineering of Synthetic Metallic Materials:

Conductors and Magnets, J. Vaciano, C. Rovira, and D.B. Amabilino (editors), NATO ASI Series,

Series C: Mathematical and Physical sciences – Vol. 518, Kluwer Academic Publishers, Dordrecht (1999),

pp. 23-40. (2)

9. “Graph Set Analysis of Hydrogen Bond Motifs”

J. Bernstein and R.E. Davis

In “Implications of Molecular and Materials Structure for New Technologies”

J.A.K. Howard, F.H. Allen and G.P. Shields (editors)

NATO Science Series, Series E, Applied Sciences – Volume 360

Kluwer Academic Publishers, Dordrecht (1999), pp. 275-290. (1)

10. “Pharmaceuticals”

J. Bernstein and J.-O. Henck

Chapter 21 of Industrial Applications of X-ray Diffraction, edited by D. Smith and F. Chung,

Marcel Decker, New York (2000), pp. 527-538. (4)

11. “Polymorphism”

J. Bernstein

In “Strength from Weakness: Structural Consequences of Weak Interactions in Molecule,

Supermolecules and Crystals”

A. Domenicano and I. Hargittai (editors)

NATO Science Series, Kluwer Academic Publishers, Dordrecht (2002), pp. 247-260.

12. “Crystal Structure Prediction and Polymorphism”

Joel Bernstein

Transactions of the American Crystallographic Association, 39, 1-10 (2004).

Actual date of publication, November 2005.

13. “Polymorphism and Patents from a Chemist’s Point of View”

J. Bernstein

In “Polymorphism in Pharmaceutical Technology”

R. Hilfiker (editor)

Elsevier, Amsterdam, (2006), pp. 365-384.(2)

14. “Crystal Polymorphism: Challenges at the Crossroads of Science and Technology”

D. Braga and J. Bernstein

Chapter in the book “Making Crystals by Design – Methods, Techniques and Applications”, edited by

D. Braga and F. Grepioni,

Wiley-VCH, Weinheim, (2006), pp. 293-314.

15. “Crystal Polymorphism”

J. Bernstein

Chapter in the book “Engineering of Crystalline Materials Properties”, edited by J.J. Novoa, D. Braga

and L. Addadi,

Springer, Dordrecht (2008), pp. 87-109.

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Refereed articles in scientific journals

16. "The Infrared Absorption of Normal and 18O-Labelled Triphenylarsine Oxide"

J. Bernstein, M. Halmann, S. Pincus and D. Samuel

Journal of the Chemical Society (London) 1964, 821-824. (43)

17. "Absorption and Fluorescence Spectra of Crystalline trans-Stilbene"

J. Bernstein and B.G. Anex

Journal of Physics, Section C 1970, L137-139. (3)

18. "The Crystal Structure of the 1:1 Complex of [3.3] Paracyclophane with Tetracyanoethylene"

J. Bernstein and K.N. Trueblood

Acta Crystallographica B27, 2078-2079 (1971). (34)

19. "The Crystal and Molecular Structure of 1,1,2,2,9,9,10,10-Octafluoro-[2.2] Paracyclophane and a

Reinvestigation of the Structure of [2.2] Paracyclophane"

Hakon Hope, J. Bernstein and K.N. Trueblood


20. "The Crystal Structure of Dipotassium cis- Hexacyanobutenediide and the Electronic Structure of the

Anion"

E. Maverick, E. Goldish, J. Bernstein, K.N. Trueblood, S. Swaminathan and Roald Hoffmann

Journal of the American Chemical Society 94, 3364-3370 (1972). (12)

21. "Conformational Studies. Part III. The Crystal and Molecular Structure of 2,4-

Dichlorobenzylideneaniline"

J. Bernstein

Journal of the Chemical Society (London) (Perkin Transactions II), 946-950 (1972). (50)

22. "Conformational Studies. Part IV. The Crystal and Molecular Structure of the Metastable Form of

p- Chlorobenzylidene-p- chloroaniline, A Planar Anil"

J. Bernstein and G.M.J. Schmidt


23. "Molecular Conformation and Electronic Structure. The Solid State Spectrum of a Planar Anil"

C.J. Eckhardt and J. Bernstein


24. "Molecular Packing Modes. Part X. The Crystal and Molecular Structures of trans, trans-Muconic Acid"

J. Bernstein and L. Leiserowitz

Israel Journal of Chemistry 10, 601-612 (1972). (12)

25. "The Polarized Specular Reflection Spectrum of Crystalline trans-Azobenzene. Evidence for Two

Transitions in the Low Energy Band"

J. Bernstein

Chemical Physics Letters 17, 43-46 (1972). (9)

26. "Spectroscopic Evidence of the Existence of Multiple Transitions of the Low Energy Band of trans-

Stilbene"

J. Bernstein

Spectrochimica Acta 29A, 147-149 (1973). (20)

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27. "Sarcophine, A New Epoxy Cembranolide of Marine Origin"

J. Bernstein, U. Shmueli, E. Zadock, Y. Kashman and I. Neeman

Tetrahedron 30, 2817-2824 (1974). (76)

28. "The Crystal and Molecular Structure of Tricyclo [5.3.0.02,6] Decane-4,9-Dione,

A Photochemical Product of the Cyclodeca-3,8-diene-1,6-dione System"

J. Bernstein


29. "The Crystal and Molecular Structure of 1,2-Diphenylcyclopentene, an Analogue of cis- Stilbene"

J. Bernstein


30. "Refinement of trans- Stilbene: A Comparison of Two Crystallographic Studies"

J. Bernstein


31. "Molecular Conformation and Electronic Structure. II. The Crystal and Molecular Structure of

p-Bromobenzylidene-p- bromoaniline"

J. Bernstein and I. Izak

Journal of Crystal and Molecular Structure 5, 257-266 (1975). (15)

32. "The Crystal Structure of the p- Molecular Compound Pyrene:p-Benzoquinone"

J. Bernstein, H. Regev, F.H. Herbstein, P. Main, S.H. Rizvi, K. Sasvari and B. Turcsanyi

Proceedings of the Royal Society (London) A347, 419-434 (1976). (11)

33. "Molecular Conformation and Electronic Structure. III. The Crystal and Molecular Structure of the

Stable Form of N-p-chlorobenzylidene-p-chloroaniline"

J. Bernstein and I. Izak


34. "Molecular Conformation and Electronic Structure. IV. The Crystal and Molecular Structure of

Form III of N-p-methylbenzylidene-p-methylaniline"

J. Bernstein and I. Bar


35. "Molecular Conformation and Electronic Structure. V. The Crystal and Molecular Structure of Form II

of

N-p-methlbenzylidene-p-methylaniline"

J. Bernstein and I. Bar


36. "The Crystal Structure of the p-Molecular Compound Benzo(c)phenanthrene:2,3-dichloro-

5,6-dicyanobenzoquinone"

J. Bernstein, H. Regev and F.H. Herbstein


37. "The Structure of Hexacyclopropylbenzene"

I. Bar, J. Bernstein and A. Christensen

Tetrahedron 33, 3177-3180 (1977). (17)

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38. "Conformational Polymorphism The Influence of Crystal Forces on Molecular Conformation"

J. Bernstein and A.T. Hagler


39. "Order and Disorder in Molecular Crystals: The Case of trans-Stilbene"

J. Bernstein and K. Mirsky


40. "Conformational Polymorphism II. Crystal Energetics by Computational Substitution. Further

Evidence for the Sensitivity of the Method"

A.T. Hagler and J. Bernstein


41. "The Crystal and Molecular Structure of the p-Molecular Compound Stilbene:(sym -

Trinitrobenzene)2"

I. Bar and J. Bernstein


42. "Conformational Polymorphism III. The Crystal and Molecular Structures of the Second and Third

Forms of Iminodiacetic Acid"

J. Bernstein


43. "Bimanes II: Structure by X-ray Diffraction"

E.M. Kosower, J. Bernstein, I. Goldberg, B. Pazhenchevsky and E. Goldstein


44. "Conformational Influence on Electronic Spectra and Structure"

J. Bernstein, T.E. Anderson and C.J. Eckhardt


45. "Polymorphism and Isomorphism as Tools to Study the Relationship Between Crystal Forces and

Molecular Conformation"

J. Bernstein and A.T. Hagler

Molecular Crystals and Liquid Crystals 50, 223-234 (1979). (15)

46. "Solid State Photooligomerization of an Extended Chiral Bifunctional Monomer"

J. Bernstein, B.S. Green and M. Reito


47. "The Crystal Structure of the p-Molecular Compound Pyrene:Fluoranil"

J. Bernstein and H. Regev

Crystal Structure Communications 9, 581-586 (1980). (4)

48. "Molecular Compounds and Complexes. XII. The Ternary Charge-Transfer Salt, Pyridine:

1-Naphthylamine:Picric Acid (Kofler's Complex)"

J. Bernstein, H. Regev and F.H. Herbstein


49. "Benzamide N-(triphenylphosphoranylidene)"



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50. "3,7-Dichloro-4,6-diphenyl-1,5-diazabicyclo[3.3.0]octa-3,6-diene-2,8-dione,and 3,7-Dichloro-4,8-

diphenyl- 1,5-diazabicyclo [3.3.0] octa-3,7-diene-2,6-dione"

J. Bernstein, E. Goldstein and I. Goldberg


51. "3,4,6,7-Tetramethyl-1,5-diazabicyclo [3.3.0] octa3,6-diene, 2,8-dione and

2,3,6,7-tetramethyl-1,5-diazabicyclo [3.3.0] octa-2,6-diene-4,8-dione"

J. Bernstein, E. Goldstein and I. Goldberg


52."The p-Molecular Complexes trans -Azobenzene:(sym -Trinitrobenzene)2 and Benzylideneaniline:

(sym - Trinitrobenzene)2"



53. "An ab initio Study of the Conformational Energetics of N-Benzylideneaniline"

J. Bernstein, Y.M. Engel and A.T. Hagler

Journal of Chemical Physics 75, 2346-2353 (1981). (49)

54. "Stabilization of Tervalent Nickel Complexes with meso -5,7,7,12,14,14-hexamethyl-1,4,8,11-tetra-

azacyclotetradecane by Axial Coordination of Anions in Aqueous Solution"

E. Zeigerson, I. Bar, J. Bernstein, L.J. Kirshenbaum and D. Meyerstein

Inorganic Chemistry 21, 73-80 (1982). (84)

55. "Molecular Conformation and Electronic Structure. VI. The Crystal and Molecular Structure of p-

methyl-N-(p-methylbenzylideneaniline) (Form I)"



56. "Conformational Polymorphism 4. Crystal Energetics of a Trimorphic System Including Disorder"


Journal of Physical Chemistry 86, 3223-3231 (1982). (19)

57. "Crystallographic Study of the 1,5-Diazabicyclo 3.3.0 Octadienedione (9,10-Dioxabimane) System:

Crystal Structures and Molecular Conformation of syn -(CH3,H)- and m-C(CN)2-syn -(CH2,CH3)-

9,10-Dioxabimanes"

I. Goldberg, J. Bernstein and E.M. Kosower


58. "Molecular Conformation and Electronic Structure. VII. The Crystal and Molecular Structure of the

Isomorphic System p -Chloro-N-(p-methylbenzylidene)aniline and p-methyl-N(p -

chlorobenzylidene)aniline"



59. "Strong Coupling in the Optical Spectra of A Squarylium Dye"

M. Tristani-Kendra, C.J. Eckhardt, J. Bernstein and E. Goldstein


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60. "Strategic Design of Organic Conductors. Structure of a Prototypical Molecule"

J.Y. Becker, J. Bernstein, S. Bittner, N. Levi and S. Shaik


61. "Bimanes.19. Characteristics of the Molecular Structures of 1,5-Diazabicyclo-[3.3.0]-Octa-

dienediones (9,10-Dioxabimanes) Determined by X-ray Crystallography"

I. Goldberg, J. Bernstein, E.M. Kosower, E. Goldstein and B. Pazhenchevsky

Journal of Heterocyclic Chemistry 20, 903-912 (1983). (13)

62. "Conformational Polymorphism. 5. Crystal Energetics of an Isomorphic System Including

Disorder"


Journal of Physical Chemistry 88, 243-248 (1984). (20)

63."Solid State Chemistry and Structures of a New Class of Dye Aggregates. The Cyanine-Oxonol

System"

M.C. Etter, R.B. Kress, J. Bernstein and D.J. Cash


64. "Conformational Polymorphism. 6. The Crystal and Molecular Structures of Form II, Form III and

Form V of N'-2-pyridilsulfonamide (Sulfapyridine)"


Journal of Pharmaceutical Sciences 74, 255-263 (1985). (35)

65. "A New Electron Donor: Synthesis of 2,3,6,7-Tetra(ethyltellura)-tetrathiafulvalene"

E. Aharon-Shalom, J. Becker, J. Bernstein, S. Bittner and S. Shaik

Tetrahedron Letters 2783-2786 (1985). (40)

66. "The Synthesis, Structure and Properties of the Complex Between a New Donor, 2,3,6,7-

Tetra(ethyltellura)tetrathia-fulvalene (TETeTTF) and Tetracyanoquinodimethan (TCNQ)"

E. Aharon-Shalom, J. Becker, J. Bernstein, S. Bittner and S. Shaik

Synthetic Metals, 11, 213-220 (1985). (14)

67. "Hypervalent Tellurium in One-Dimensional Extended Structures Containing Te5n- Units"

J. Bernstein and R. Hoffman

Inorganic Chemistry, 24, 4100-4108 (1985). (28)

68. "The Structure and Spectral Properties of a Squarylium Dye, 2,4-bis-(1n-butyl- 2(1H)-

quinolylidenemethyl)-1,3- cyclobutadienediylium-1,3-diolate"

J. Bernstein, M. Tristani-Kendra and C.J. Eckhardt

Journal of Physical Chemistry, 90, 1069-1073 (1986). (13)

69. "Modification of Crystal Packing and Molecular Conformation via Systematic Substitution"

Invited paper for Tetrahedron Symposium in Print on Chemistry in Rigid Media


Tetrahedron, 43, 1299-1305 (1987). (16)

70. "The 1:1 Mixed Stack Complex of Tetrathiafulvalene and 2,5-Dibenzyltetracyanoquino-dimethane

(TTF : DBTCNQ) at 115˚K"

E. Aharon-Shalom, J.Y. Becker, J. Bernstein, S. Bittner and S.S. Shaik

Israel Journal of Chemistry, 27, 375-380 (1986). (Actual date of publication, 1987). (2)

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71. "The Wave-Particle Duality. Teaching via a Metaphor"

J. Bernstein and S. Shaik

Journal of Chemical Education 65, 339-340 (1988).

72. "Synthesis and Properties of Archetypical Donor-Acceptor-Donor (D2A) Molecules”

J.Y. Becker, J. Bernstein, S. Bittner, N. Levi, S.S. Shaik and N. Zer-Zion

Journal of Organic Chemistry 53, 1689-1694 (1988). (27)

73."Polymorph IV of 4-Amino-N-2-pyridinyl benzene sulfonamide, Sulfapyridine”

J. Bernstein

Acta Crystallographica C44, 900-902 (1988). (13)

74."Preparation and Structure of 2,5-bis-(phenylthio)-benzoquinone and 2,6-bis-(phenylthio) benzoquinone.”

J.Y. Becker, J. Bernstein, S. Bittner, E. Harlev, J.A.R.P. Sarma and S.S. Shaik

Nouveau Journal de Chemie, 12, 875-880 (1988). (10)

75. "The Polymorphic Structures of a Squarylium Dye. The Monoclinic (Green) and Triclinic (Violet)

Forms of 2,4 bis(2-hydroxy-4-diethylaminophenyl)-1,3-cyclobutadienediylium 1,3-diolate"

J. Bernstein and E. Goldstein

Molecular Crystals and Liquid Crystals 164, 213-219 (1988). (30)

76. "The Structure of Tetra(telluroethyl)-TTF(TTeC2-TTF)"

J.Y. Becker, J. Bernstein, S. Bittner, J.A.R.P. Sarma L. Shahal and S.S. Shaik

Acta Crystallographica C44, 1770-72 (1988). (2)

77."Synthesis, Crystal Structure and Physical Properties of a New Type of Compound Derived from an

Unusual Reaction of 2-Lithio-4,5-disubsituted-1,3-dithioles with Carbon Disulfide"

A. Moradpur, S. Bittner, J.A.R.P. Sarma and J. Bernstein

Journal of the Chemical Society (Perkin I) 2751-2755 (1988). (4)

78."Preparation and Structure of a Novel Organotellurium Derivative:

Di(tetrathiafulvalene)telluride [(TTF)2Te]"

J.Y. Becker, J. Bernstein, S. Bittner, J.A.R.P. Sarma and L. Shahal

Tetrahedron Letters, 29, 6177-6180 (1988). (32)

79. "On the Inapplicability of the Lehnert Reagent for 1,2-Dicyanomethylation of 2,5- and 2,6-

Diphenylthiobenzoquinones; Synthesis and Structure of Isomeric 2-Amino-5-hydroxy-4,6- and 2-

amino-5- hydroxy-4,7-diphenylthiobenzo[B]furan-3-carbonitriles"

J.Y. Becker, J. Bernstein, S. Bittner, E. Harlev and J.A.R.P. Sarma

J. Chem. Soc. Perkin II, 1988, 1157-1161. (4)

80. "Strategic Design of Organic Conductors. Preparation and Characterization of Electron-Donor-

Acceptor Complexes with Prefixed Stoichiometry"

J.Y. Becker, J. Bernstein, S. Bittner and S.S. Shaik

Synthetic Metals 27, B197-B204 (1988). (9)

81. "Crystal Structure and Solid State Photoreactivity of 2,5-Dibenzylidenecyclopent-3-en-1-one and

Its Tetrachloro Derivative"

G.R. Desiraju, J.Bernstein, K.V.R. Kishan and J.A.R.P. Sarma

Tetrahedron. Letters 30, 3029-3033 (1989). (6)

82."Structural Trends in Potential Organic Conductors Based on (Donor-CH2-)2 TCNQ Molecules"

14

J.Y. Becker, J. Bernstein, S. Bittner, J.A.R.P. Sarma and S.S. Shaik

Chemistry of Materials 1, 412-420 (1989). (12)

83."Solid State Nucleophilic Aromatic Substitution Reaction of a Carboxylic Acid Cocrystal"

M.C. Etter, G.M. Frankenbach and J. Bernstein

Tetrahedron Letters 30, 3617-3620 (1989). (35)

84."Tryptophanyl-tRNA Synthetase from Bacillus subtilis. Characterization and Role of Hydrophobicity

in Substrate Recognition"

Z.-J. Xu, M.L. Love, L.Y.Y. Ma, M. Blum, P.M. Bronskill, J. Bernstein, A.A. Grey, T. Hofmann, N.

Camerman and J. Y.-F. Wong

Journal of Biological Chemistry 264, 4304-4311 (1989). (37)

85. "Decoding Hydrogen Bond Patterns. The Case of Iminodiacetic Acid"

J. Bernstein, M.C. Etter and J.C. MacDonald

Journal of the Chemical Society, Perkin Transactions II, 695-698 (1990). (43)

86. "New Te-TTF Dimers, Aryl-substituted TCNQ, and Quinone Derivatives: Synthesis,

Electrochemistry and Molecular Structure"

J.Y. Becker, J. Bernstein, S. Bittner, and S.S. Shaik

Pure and Applied Chemistry, 62, 467-472 (1990). (24)

87."Graph Set Analysis of Hydrogen-Bond Patterns in Organic Crystals"

M.C. Etter, J.D. MacDonald and J. Bernstein

Acta Crystallographica, B46, 256-260 (1990). (734)

88."Identification and Characterization of Crystalline and Amorphous HM-PAO Fractions"

I. Feinstein-Jaffe, R. Azoury, J. Bernstein, M. Boazi and J.A.R.P. Sarma

Journal of Crystal Growth 100, 68-74 (1990). (3)

89. "1',2',1,6-dicarbethoxy -7:9- diketobicyclo-2,2,4-decanonaphthalene"

J. Bernstein and S. Yakir-Zamir

Acta Crystallographica, C47, 441-442 (1991).

90. "Generation of Unknown Crystal Phases for Aromatic Hydrocarbons by Packing Energy Calculations"

J. Bernstein, J.A.R.P. Sarma and A. Gavezzotti

Chemical Physics Letters 174 , 361-368 (1990). (37)

91. "Preparation of Bromo- and 1,2-Dibromotetrathiafulvalenes (TTFBr and 1,2-TTFBr2)"

J.Y. Becker, J. Bernstein, S. Bittner, L. Shahal and S.S. Shaik

Journal of the Chemical Society, Chemical Communications, 1991, 92-93. (29)

92."Synthesis and Structure of Molecules Containing Linked Donor and Acceptor Units,

New Tellurium Derivatives and Their Charge-Transfer Complexes"

J.Y. Becker, J. Bernstein, S. Bittner and S.S. Shaik

Synthetic Metals, 41-43, 2523-2528 (1991). (3)

93. "Electronic Spectra and Structure of a New Class of Charge-Transfer Complexes:

Tethered Charge- Transfer Complexes"

N.M. Peachey, C.J. Eckhardt and J. Bernstein

15


94. "Polymorphism of L-Glutamic Acid: Decoding the - Phase Relationship via Graph

Set Analysis"

J. Bernstein

Acta Crystallographica, B47, 1004-1009 (1991). (26)

95. "Synthesis and Electrochemical Properties of Benzo[b]naphtho-[2,3-e] [1,4]-dioxin-

6,11-quinones and Their N,N'-Dicyanoquinonediimine Derivatives"

T. Czekanski, M. Hanack, J.Y. Becker, J. Bernstein, S. Bittner, L. Kaufman-Orenstein

and D. Peleg

Journal of Organic Chemistry, 56, 1569-1573 (1991). (18)

96. "Levonorgestrel Cyclopentylcarboxylate 3-oxime"

J. Bernstein, A. Weissman, D. Britton, E.G. Rippe and J. Hedenstrom

Acta Crystallographica , A48, 214-215 (1992). (2)

97. "Synthesis and X-ray Structure of a Novel Organotelluride di(tetrathiafulvalene)

ditelluride [(TTFTe)2]"

J.Y. Becker, J. Bernstein, M. Dayan and L. Shahal

Journal of the Chemical Society, Chemical Communications, 1048 (1992). (24)

98. "Packing Analysis and the Crystal Chemistry of 2,5-Dibenzylidenecyclopent-3-ene-1-

one”

Rationale for a Nontopochemical Solid State Reaction"

J.A.R.P. Sarma and J. Bernstein

Molecular Engineering, 2, 103-116 (1992).

99. "[2+4} Cycloaddition to Tetrathiafulvalene (TTF): A New Route to Multisulfur TTF

Derivatives"

V.Y. Khodorkovsky, J.Y. Becker and J. Bernstein

Synthesis, 1992, 1071-1072. (25)

100. "Crystal Growth, Polymorphism and Structure-Property Relationships in Organic Crystals"

J. Bernstein

Journal of Physics D: Applied Physics, 26, 66-76 (1993). (80)

101. "Conformational Studies of the m-Dihalosubstituted Benzylideneaniline System"

S. Zamir and J. Bernstein

Invited contribution to Special Issue - Models in Chemistry

In Memoriam A.I. Kitaigorodskii,

Acta Chimica Hungarica , 130, 301-325 (1993). (4)

102. "A Structural and Electronic Study of Donors Composed of Two TTF Moieties Linked by Tellurium

Bridges"

J.D. Martin, E. Canadell J.Y. Becker and J. Bernstein

Chemistry of Materials, 5, 1199-1203 (1993). (23)

16

103. "A New Route Towards Multisulfur TTF-Based Components of Organic Metals"

V.Y. Khodorkovsky, J.Y. Becker and J. Bernstein

Synthetic Metals, 55-57, 1931-1935 (1993). (6)

104. "A Single Crystal to Single Crystal Reversible Phase Transition which Exhibits the Hopping

Effect"

S. Zamir, J. Bernstein, D. J. Greenwood.

Molecular Crystals and Liquid Crystals, 242, 193-200 (1994). (6)

105. "A Crystal Packing - Melting Point Correlation for Quaternary Ammonium Salts"

D. Mason and J. Bernstein

Molecular Crystals and Liquid Crystals, 242, 179-191 (1994). (6)

106. "Conformational Studies of the N-(3-Halobenzylidene)-3-haloaniline System.

Part 2 Molecular Energetics"

S. Zamir, J. Bernstein, A Ioffe, J. Brunvoll, M. Kolonits, and I Hargittai.

Journal of the Chemical Society Perkin Transactions 2, 895-900 (1994). (11)

107. " New Direct Iodination of Tetrathiafulvalen (TTF): Mono- and Diodo-TTF and their X-ray

Structures"

C. Wang, A. Ellern, V. Khodorkovsky, J. Bernstein and J.Y. Becker

Journal of the Chemical Society, Chemical Communications, 983-984 (1994). (44)

108. "Phenyl Groups as Molecular Fasteners: Phenytelluro Substituted Tetrathiafulvalenes"

V.Y. Khodorkovsky, C. Wang, J.Y. Becker A. Ellern, L. Shapiro and J. Bernstein

Advanced Materials, 6, 656-659 (1994). (5)

109. "A New Polymorphic Modification of Tetrathiafulvalene (TTF). Crystal Structure,

Lattice Energy and van der Waals Interactions":

A. Ellern, J. Bernstein, J.Y. Becker, S. Zamir, L. Shahal and S. Cohen

Chemistry of Materials, 6, 1378-1385 (1994). (35)

110. "The Hofmann Clathrates: Weak Orbital Interactions in the Solid State"

E. Ruiz, S. Alvarez, R. Hoffmann and J. Bernstein


111. "Charge Transfer Complexes of (TTFTe)2: Preparation, Structure and Electrical Conductivity"

J.Y. Becker, J. Bernstein, M. Dayan, A. Ellern, and L Shahal

Advanced Materials, 6, 758-761 (1994). (8)

112. "A New Molecular Donor Containing Two Tetrathiafulvalene (TTF) Units Fused to 1,4-Ditellurine:

Synthesis, X-ray Structure, CT Complex and Conductivity"

C. Wang, A. Ellern, V. Khodorkovsky, J.Y. Becker and J. Bernstein


113. "A Unique Molecular Donor Containing Two Tetrathiafulvalene (TTF) Units Fused to 1,4-

Ditellurin: Synthesis, X-ray Structure and Cyclic Voltammetry"

C. Wang, A. Ellern, J.Y. Becker and J. Bernstein

Tetrahedron Letters 35, 8489-8492 (1994). (17)

17

114. "New -Electron Donors Containing Two Tetrathiafulvalene Units Fused to 1,4-Dithin and a Conducting

Charge- transfer Complex with Tetracyanoquinodimethane"

Emad Aqad, James Y. Becker, Joel Bernstein, Arkady Ellern, Vladimir Khodorkovsky and Lev Shapiro


115. "Graph-Set Analysis of Hydrogen-Bond Patterns in Organic Crystals"

J. Bernstein, R.E. Davis, L. Shimoni and N.L. Chang

Angewandte Chemie International Edition in English 34, 1555-1575 (1995)

(German version: Angewandte Chemie 107, 1687-1706 (1995). (2672)

116. "Disappearing Polymorphs"

J.D. Dunitz and J. Bernstein

Accounts of Chemical Research 28, 193-200 (1995). (386)

117. "New Angular Molecular Donor Containing Two Tetrathiafulvalene (TTF) Units Fused to

Selenophene: Synthesis, X-ray Structure, Cyclic Voltammetry and Conducting Charge Transfer

Complex with TCNQ"

C. Wang, A. Ellern, J.Y. Becker and J. Bernstein

Advanced Materials 7, 644-646 (1995). (9)

118. "Halogenated Tetrathiafulvalenes (TTF's) : Preparation, X-ray Structure and Cyclic Voltammetry"

C.-S. Wang, A. Ellern, V. Khodorkovsky, J.Y. Becker and J. Bernstein

Journal of Materials Chemistry 5, 1559-1562 (1995). (17)

119. "The Mystery of Tetrathiafulvalenefulvalenyl (TTF-TTF) "

V. Khodorkovsky, H. Gerstman, A. Ellern, J.Y. Becker and J. Bernstein


120. "Stabilization of a High Energy Molecular Conformation by Specific Intermolecular Forces.

A Novel Planar Benzylideneaniline System.”

O. Navon and J. Bernstein

Structural Chemistry, 8, 3-11 (1997). (3)

121. "Chains, Ladders and Two-Dimensional Sheets Utilizing Halogen...Halogen and

Halogen...Hydrogen Interactions"

O. Navon, J. Bernstein and V. Khodorkovsky

Angewandte Chemie International Edition in English 36, 601-603 (1997). (52)

122. “Is the “Unusual” Three Center D-H- - -A-M Hydrogen Bond Really Unusual?”

H. Dadon and J. Bernstein

Inorganic Chemistry 36, 2898-2900 (1997). (11)

123. “Synthesis and Properties of Novel Components for Organic Metals”

E. Møkved, G. Faccin, D. Manfrotto, H. Kjøsen, J.Y. Becker, L. Shapiro, A. Ellern,

J. Bernstein and V. Khodorkovsky


124. "Disappearing and Reappearing Polymorphs - An Anathema to Crystal Engineering?"


Crystal Engineering, 1, 119-128 (1998). (26)

125.”Graph Set Analysis of Hydrogen-Bond Patterns in Molecular Crystals”

18

R.E. Davis and J. Bernstein

Transactions of the American Crystallographic Association, 33, 7-21 (1998).

126. “Concomitant Polymorphs”

J. Bernstein, R. Davey and J.-O. Henck

Angewandte Chemie International Edition in English (review) 38, 3440-3461 (1999).

Angewandte Chemie (German version) (review) 111, 3646-3669 (1999). (370)

127. “Graph Set Analysis of Hydrogen Bond Patterns. Some Mathematical Concepts”

J. Grell, J. Bernstein and G. Tinhofer

Acta Crystallographic Section B, B55, 1030-1043 (1999). (95)

128. “Synthesis of a Novel Rigid Tetrathiafulvalene---benzoquinone Diad (TTF-s-Q) with

Inherent Structural Configuration for Intramolecular Charge-transfer”

E. Tsiperman, T. Regev, J.Y. Becker, J. Bernstein, A. Ellern, V. Khodorkovsky, A. Shames

and L. Shapiro

Journal of the Chemical Society, Chemical Communications 1125-1126 (1999). (20)

129. “Disappearing and Reappearing Polymorphs. The Case of Benzocaine:Picric Acid”

J.-O. Henck, J. Bernstein, A. Ellern and R. Boese

Journal of the American Chemical Society 123, 1834-1841 (2001).

This paper was cited in the weekly column “Editor’s Choice: Highlights of the Recent Literature”

of Science, March 2, 2001, 291, p. 1665. (43)

130. “Synthesis and Crystal Engineering of New Halogenated Tetrathiafulvalene (TTF) Derivatives

and Their Charge Transfer Complexes and Radical Ion Salts"

A.S. Batsanov, M.R. Bryce, A. Chesney, J.A.K. Howard, D.E. John, A.J. Moore, C.L. Wood,

H. Gershtenman, J.Y. Becker, V.Y. Khodorkovsky, A. Ellern, J. Bernstein, I.F. Perepichka, V. Rotello,

M. Gray and A.O. Cuello


131. “Investigation of Hydrogen Bond Patterns: A Review of Mathematical Tools for the Graph Set Approach.”

J. Grell, J. Bernstein and G. Tinhofer

Crystallography Reviews 8, 1-56, (2002). (1)

132. “Copper Salts of Rigid N,N’-Dicyanoquinone Diimine Derivatives”

L. Kaufmann-Orenstein, J.Y. Becker, J. Bernstein, J.M. Rubin, and M. Hanack

Journal of Solid State Chemistry (Special volume devoted to Molecular Metals) 168, 690-695 (2002). (1)

133. “Crystal Structure of 2,4,5,7-Tetranitrofluorene”

J.M. Rubin, R. Mazor, J. Bernstein, V. Khodorkovsky

Zeitschrift fur Kristallographie NCS 217, 439-440 (2002).

134. “Determining the Similarity of Conformational Polymorphs”

A. Enosh, K. Kedem and J. Bernstein

Algorithms-ESA 2002, Proceedings Lecture Notes in Computer Science 2461, 436-448 (2002).

135. “2,4-Diaminobenzenesulfonic Acid – An Old System with Some New Surprises”

J.M. Rubin and J. Bernstein

Helvetica Chimica Acta 86, 3037-3054 (2003).

Invited contribution to the Festschrift honoring Prof. J.D. Dunitz on his 80th

Birthday

19

136. “Variable Temperature Studies of a Polymorphic System Comprising Two Pairs of Enantiotropically-

Related Forms: [S,S]-Ethambutol Dihydrochloride”

J.M. Rubin-Preminger, J. Bernstein, R.K. Harris, I. Radosavljevic-Evans and P. Ghi

Crystal Growth and Design 4, 431-439 (2004). (9)

137. “[R,S]-Ethambutol Dihydrochloride: Variable Temperature Studies of Dimorphic System with Very

Similar Packing”

J.M. Rubin-Preminger, J. Bernstein, R.K. Harris, I. Radosavljevic-Evans and P.Y. Ghi

Journal of Pharmaceutical Sciences 93, 2810-2819 (2004). (2)

138. “3-Aminobenzenesulfonic acid: A Disappearing Polymorph”

J.M. Rubin-Preminger and J. Bernstein

Crystal Growth & Design, 5, 1343-1349 (2005). (6)

139. “Groth’s Original Concomitant Polymorphs Revisited”

M. Rafilovich, J. Bernstein, S.L. Price, P. Panagiotopolis, R. Harris

Crystal Growth and Design, 5, 2197-2209 (2005). (10)

Invited contribution in special issue in honor of Professor Michael McBride on his 65th

birthday

140. “Molecular Crystals: Pinching Polymorphs”

J. Bernstein

Nature Materials, 4, 2818-2819 (2005). (3) Invited News & Views Article

141. “…And Another Comment on Pseudopolymorphism”

J. Bernstein

Crystal Growth and Design 5 1661-1662 (2005). (26) (Lead Perspectives article)

142. “Cultivating Crystal Forms”

J. Bernstein

Chemical Communications, 5007-5012 (2005). (38)

Invited Focus Article celebrating the 40th

anniversary of Chemical Communications

143. “Three Crystal Forms of Tetrakis(2-2-nitrobenzoato-O,O’)-diaqua-di-copper(ii)”

Z. Deutsch, J. M. Rubin-Preminger, J. Bernstein and J. Y. Becker

Crystal Engineering Communications, 8, 41-50 (2006). (3)

144. “Characterization of the Polymorphs of Aminoacetonitrile Hydrochloride and Crystal

Structures of the Stable Polymorph”

S. Wishkerman and J. Bernstein

Crystal Engineering Communications 8, 245-249 (2006). (1)

145. “Polymorphism in 4-Methoxy-3- nitrobenzaldhyde” S Wishkerman, J. Bernstein

and P. W. Stephens

Crystal Growth & Design, 6, 1366-1373 (2006). (3)

The cover of this issue was composed of figures from this paper

146. “Serendipity and the Polymorphs of Benzidene”

M. Rafilovich and J. Bernstein

Journal of the American Chemical Society, 128, 12185-12191 (2006). (18)

20

147. “Designing a Cocrystal of γ-Amino Butyric Acid”

M. Wenger and J. Bernstein

Angewandte Chemie International Edition in English, 45, 7966-7969 (2006). (9)

148. “Disruption of Hexagonal Networks of Trimesic Acid (Benzene-1,3,5-Tricarboxylic Acid, TMA)

by Acetic Acid”

I. Goldberg and J. Bernstein

Chemical Communications, 132-134 (2007). (3)

149. “A Co-crystal Design Gone Awry? New Dimorphic Hydrate of Oxalic Acid.” M. Wenger and J. Bernstein

Molecular Pharmaceutics, 4, 355-359 (2007). (7)

Invited contribution for a special issue on pharmaceutical co-crystals

150. “Benzidine: A Co-crystallization Agent for Proton Acceptors”

M. Rafilovich, J. Bernstein, M. B. Hickey,

and M. Tauber

Crystal Growth and Design, 7, 1777-1782 (2007). (1)

151. “Co-crystal of Urea and Imidazolidone –Formation of an Unexpected 1-D Substructure in a

Plausibly Predictable Co-crystal”

Z. Deutsch and J. Bernstein

Crystal Growth and Design, 8, 3537-3542 (2008).

152. “Polymorphism and Structural Mechanism of the Phase Transformation of Phenyl Carbamate”

S. Wishkerman and J. Bernstein

Chemistry-A European Journal 14, 197-203 (2008).

153. “Disappearing and Reappearing Polymorphism in p-Methylchalcone”

I. Barsky, J. Bernstein, P. W. Stephens, K. Stone, E. Cheung, M. B. Hickey and J.-O. Henck║

Crystal Growth & Design, 8, 63-70 (2008).

Invited paper to special issue on polymorphism. Selected from 100 papers as a Brookhaven National

Laboratory National Synchrotron Light Source Highlight Paper for 2008.

154.“Statistical Survey of Hydrogen Bond Motifs in Crystallographic Special Symmetry Positions,

and the Influence of Chirality of Molecules in the Crystal on Formation of Hydrogen Bond Rings”

Motifs.”

S. Eppel and J. Bernstein

Acta Crystallographica, Section B, B64, 50-56 (2008). (5)

155. “An Alternate Crystal Form of Gabapentin – A Cocrystal with Oxalic Acid” M. Wenger and J. Bernstein

Crystal Growth & Design 8, 1595-1598 (2008). (2)

156. “Crystal Structures and Characterization of the Polymorphs of (2-furyl)oxoacetamide”

I. Barsky and J. Bernstein

CrystEngComm 10, 669-674 (2008). (1)

157.“Polymorphic Perversity: Crystal Structures with Many Symmetry-Independent Molecules in the

Unit Cell”.

J. Bernstein, J.D. Dunitz and A. Gavezzotti

Crystal Growth & Design 8, 2001-2108 (2008). (3)

21

158. “The structure of a new ternary aluminide Th4Fe2Al32”

D. Enidjer, A. Venkert, 1. Bernstein and M. Talianker

Journal of Alloys and Compounds 474, 169-173 (2009).

159. “The study of the polymorphic system of 2-chloro-4-nitrobenzoic acid”

I. Barsky, J. Bernstein, P. Stephens and K. Stone

New Journal of Chemistry 32, 1747-1753 (2008).(1)

Invited paper for a special issue on polymorphism

160. “Statistically based design of multicomponent crystals with the three center hydrogen bond”.

S. Eppel and J. Bernstein


161. “Co-crystals of crown ethers and urea derivatives”.

S. Wishkerman, J. Bernstein and M.B. Hickey


162. “Structure and Reactivity of Alkylamine Surfactants: Relevance to Nanoscale Synthesis and

Assembly”

N. Belman, J.N. Israelachvili, Y. Li, C.R. Safinia, J. Bernstein and Y. Golana

Nano Letters, 9, 2088-2093 (2009).

163. “The Temperature-Dependent Structure of Alkylamines and Their Corresponding Alkylamine-

Alkylcarbamates”

N. Belman, J.N. Israelachvili, Y. Li, C.R. Safinya, J. Bernstein and Y. Golana

Journal of the American Chemical Society, 131, 9108-9113 (2009).

164. “Design and Preparation of Co-crystals Utilizing the

R 4

2(8) Hydrogen-Bonding Motif”

J. Bernstein, R. Boese, S.A. Cirkel and J.J. Novoa

Chemistry-A European Journal, 16, 9047-9055 (2010).

165. “The Co-crystal of Two GRAS Substances: (Citric acid).(Nicotinamide). Formation of Three

Hydrogen Bonding Heterosynthons in One Co-crystal”

A. Lemmerer, and J. Bernstein

Crystal Engineering Communications 12, 2029-2033 (2010).

166. “Covalent assistance to supramolecular synthesis: directing the supramolecular assembly of co-

crystals by in situ modification of hydrogen bonding functionality

A. Lemmerer, J. Bernstein and V. Kahlenberg

Crystal Engineering Communications 13, 55-59 (2011)

167. “Simultaneous Covalent and Supramolecular Synthesis of Pharmaceutical Co-crystals Using the

API Isoniazid: an Ideal Supramolecular Reagent.

A. Lemmerer, V. Kahlenberg and J. Bernstein

Crystal Engineering Commnications, DOI: 10, 1039/c.

168. “Synthesis, Characterization and Molecular Modeling of a Pharmaceutical Co-crystal: (2-Chloro-4-nitrobenzoic acid):(Nicotinamide)“ A. Lemmerer, C. Esterhuysen and J. Bernstein

Journal of Pharmaceutical Sciences 98, 4054-4071 (2010)

An invited contribution to a special issue honoring Professor Stephen Byrn.

22

169. “’Jumping Crystals’ of the Anticholinergic Agent Oxitropium Bromide. Structural, Spectroscopic

and Mechanical Aspects of the Thermosalient Phenomenon”

Z. Skoko, S. Zamir, P. Naumov, Panče and J. Bernstein

Journal of the American Chemical Society 132, 14191-14202 (2010).

This paper was highlighted by Nature Chemistry – 15 October 2010

Doi:1038/nchem.903

http://www.nature.com/nchem/reshigh/2010/1010/full/nchem.903.html

It was also highlighted as “The Structure of the Week” by Crystal Growth & Design

#8 October 10, 2010

https://communities.ac.org/docs/DOC-3662

170. “Polymorphism – A Perspective”

J. Bernstein

Crystal Growth and Design, 11, 632-650 (2011)

An invited review marking the tenth anniversary of the journal.

171. "An Investigation of the Hydrogen-bond Preferences and Co-crystallization Behavior of Three

Didonor Compounds."

A. Lemmerer, D. Adsmond, Daniel and J. Bernstein

Crystal Growth & Design, 11, 2011-2019 (2011).

172. “A Tale of Two Polymorphic Pharmaceuticals: Pyrithyldione and Propyphenazone and their

1937 Co-crystal Patent”

A. Lemmerer, J. Bernstein, U. J. Griesser, V. Kahlenberg, D.M. Többens, S. H. Lapidus, P. W.

Stephens¶ and C. Esterhuysen

Chemistry – A European Journal,, in press.

173. “Hydrogen Bonding Patterns of the Co-Crystal Containing the Pharmaceutically Active

Ingredient Isoniazid and Terephthalic Acid

A. Lemmerer, J. Bernstein, V. Kahlenburg

Journal of Chemical Crystallography, 41, 991-997 (2011).

174. “N’-(propan-2-ylidene)nicotinohydrazide and sebacic acid: a modulated co-crystal”

H. Kruger, A. Lemmerer, V. Kahlenberg and J. Bernstein

submitted

175. “Covalent assistance in supramolecular synthesis: In-situ modification and masking of the

hydrogen bonding functionality of the supramolecular reagent isoniazid in co-crystals"

A. Lemmerer, J. Bernstein and V. Kahlenberg

Crystal Engineering Communications, 13, 5692-5708 (2011).

176. “Acridine 0.75 Hydrate”

E. Schur, J. Bernstein, A, Lemmerer and R. Vainer

Acta Crystallographica Section E, Structure Reports E67, o2761 (2011).

177. “Supramolecular polymorphism of the 1:1 molecular salt (adamantane-1-carboxylate-3,5,7-

tricarboxylic acid)·(hexamethylenetetraminium). A “failed” crystal engineering attempt.”

A. Lemmerer, J, Bernstein and M. Spackman

Chemical Communications, in press.

http://www.nature.com/nchem/reshigh/2010/1010/full/nchem.903.html

https://communities.ac.org/docs/DOC-3662

Book Reviews

1. "Historical Atlas of Crystallography" J. Lima-de-Faria, editor, Kluwer Academic Publishers,

Dordrecht, Holland, 1992.

Reviewed for Structural Chemistry, 4, 67-68 (1993).

2. "Crystallography in Modern Chemistry - A Resource Book of Crystal Structures"

by T.C.W. Mak and Gong-Du Zhou, published by Wiley Interscience, 1992.

Reviewed for Molecular Crystals and Liquid Crystals, 237, 496-498 (1993).

3. "Crystal Structure Analysis for Chemists and Biologists"

by J.P. Glusker, M. Lewis and M. Rossi, published by VCH Publishers, 1994.

Reviewed for Acta Crystallographica B51, 382-384 (1995).

4. "Applications of Graph Theory and Topology in Inorganic Cluster and Coordination Chemistry"

by R.B. King, published by CRC Press, 1993

Reviewed for Structural Chemistry 6, 403 (1995).

Joel Bernstein page 25

25

LECTURES AND PRESENTATIONS AT MEETINGS AND INVITED SEMINARS

(a) Invited plenary lectures at conferences/meetings (since 1995)

1. "Powder Diffraction, Polymorphism and Patents"

First Lev Zevin Memorial Lecture, Ben-Gurion University of the Negev, April, 1995

2. "Graph Sets and Hydrogen Bond Functionality"

presented at Symposium honoring Prof. F.H. Herbstein on the occasion of his retirement,

Israel Crystallographic Society, annual meeting, Technion, Haifa, May, 1995

3. "Polymorphism and Hydrogen Bonding - Graph Set Description", presented at NATO Advanced

Workshop on Supramolecular Chemistry", Sestri Levante,Italy, September, 1995.

4. "Hydrogen Bond Pattern Functionality - Graph Set Description", presented at the Third Italian-Israeli

Meeting on Chemical Crystallography: "Crystal Structure and Molecular Recognition", Ferrara, Italy,

February, 1996.

5. "Thermal and Structural Studies of a Single Crystal Reversible Phase Transition which

Exhibits the 'Hopping Effect'", presented at the Israel - Hungary Binational Conference on Thermal

Analysis and Calorimetry of Materials, Ein-Bokek, Israel, March, 1996.

6. "Hydrogen-Bond Pattern Functionality and Graph Sets", presented at the 5th International Summer

School on Supramolecular Chemistry, held in Ustron, Poland, June, 1996.

“Hydrogen Bond Patterns and Graph Sets”, presented at the session entitled “Exotic Molecules” of the

XVII Congress and General Assembly of the International Union of Crystallography, Seattle,

Washington, August, 1996.

7.”Disappearing Polymorphs - An Anathema to Crystal Engineering?” Invited Plenary Lecture at the

symposium on "Crystal Engineering", held as part of the 5th Chemical Congress of North America,

Cancun, Mexico, November, 1997.

8. “Disappearing and Reappearing Polymorphs - An Anathema to Crystal Engineering?” Invited Plenary

Lecture at the International Symposium, "Polymorphism in Molecular Crystals: 100 Years of

Ostwald's Rule", held in Manchester, England, December, 1997

9. “Structural and Crystallographic Aspects of Supramolecular Engineering”, Invited Plenary Lecture at

the NATO Advanced Research Workshop on “Supramolecular Chemistry and Conducting

Materials”, held in Barcelona, Spain, January, 1998.

10. “Disappearing and Reappearing Polymorphs”, Invited Plenary Lecture at the two day symposium on

polymorphism at the Annual Meeting of the Royal Society of Chemistry, Durham, England, April,

1998

11. “Graph Set Analysis of Hydrogen Bond Motifs”, Invited Plenary Lecture at the 27th International

School of Crystallography, Ettore Majorana Centre, Erice, Sicily, May, 1998.

12. “Analytical Techniques for Studying Polymorphism”, Invited Plenary Lecture at the SmithKline

Beecham R&D Analytical Sciences Colloquium, held at Robinson College, Cambridge University,

July, 1998.


26

13. “Disappearing and Reappearing Polymorphs”, Invited Plenary Lecture at 1st International

Symposium on Aspects of Polymorphism and Crystallization – Chemical Development Issues”,

Hinckley, Leicestershire, UK, June, 1999.

14. Hydrogen Bond Patterns in Crystals”, Invited Plenary Lecture at the Annual Meeting of the South

African Crystallographic Society, Johannesburg, September, 1999.

15. “X-ray Powder Diffraction in the Characterization of Pharmaceuticals”, Invited Plenary Lecture at the

Pharmaceutical Powder X-ray Diffraction Symposium, Philadelphia, PA, September, 1999

16. “Polymorphism”, Invited Plenary Lecture at the 32nd

Course, International School of Crystallography

on Structural Consequences of Weak Interaction in Molecules, Supermolecules and Crystals, Erice,

Sicily, May, 2001.

17. “Crystallography in the Courtroom”, Invited Plenary Lecture at the 32nd

Course, International School

of Crystallography on Structural Consequences of Weak Interaction in Molecules, Supermolecules

and Crystals, Erice, Sicily, May, 2001.

18. “Polymorphs – How Different and How Similar”, Invited Plenary Lecture at the IIIrd International

Conference on Crystallography and Drug Design, Lodz, Poland, August, 2001.

19. “Polymorphs – How Different and How Similar”, Invited (Opening)Plenary Lecture, 20th

European

Crystallographic Meeting, Krakow, Poland, August, 2001.

20. “Hydrogen Bond Patterns in Crystals”, presented at the XIVth Conference-Workshop Horizons in

Hydrogen Bond Research, Torino, Italy, September, 2001.

21. “Polymorphism and Patents: Some Case Studies from a Chemist’s Point of View”, Invited Plenary

Lecture at the 3rd

International Symposium on Polymorphism and Crystallization – Chemical

Development Issues, San Francisco, November, 2001.

22. “Polymorphism in Crystals – How Similar and How Different”, Prof. Joseph Klein Memorial

Lecture, Hebrew University of Jerusalem, May, 2002.

23. “Courtship”, Plenary Lecture at the 33nd

Course, International School of Crystallography Genomes to

Drugs through Crystallography, Erice, Sicily, June, 2002.

24. “Polymorphism in Crystals” Opening Keynote Lecture, American Chemical Society PROspectives

Symposium on Polymorphism, Solvates and Crystallization, held In Tampa, Florida, February, 2003.

25. “Polymorphs – How Similar and How Different” Invited Plenary Lecture at the Fourth Symposium

on Polymorphism and Crystallization, organized by Scientific Update, Chester, United Kingdom,

April, 2003

26. “Polymorphism in Crystals“, Opening Plenary Lecture, German Pharmaceutical Society Seminar on

Polymorphism of Drugs, Bonn/Königswinter, Germany, May, 2003.


27

27. “Polymorphs and Patents”, Closing Plenary Lecture, German Pharmaceutical Society Seminar on

Polymorphism of Drugs, Bonn/Königswinter, Germany, May 2003.

28. “Recent Adventures in Polymorphland”, presented at ICCOSS-International Conference on the

Chemistry of the Organic Solid State, to be held in Sydney, Australia, July, 2003.

29. “Supramolecular Chemistry, Polymorphism and Crystal Engineering”, invited lecture at the

“Symposium on “Supramolecular Construction and Function” at the joint International Union of Pure

and Applied Chemistry (IUPAC) and Canadian Society for Chemistry (CSC) held in Ottawa, Canada,

August, 2003.

30. “Polymorphism and Structure/Property Relations” at the “Summit on Polymorphism and Intellectural

Property Issues”, Philadelphia, November, 2003.

31. “Chemistry in the Courtroom”, plenary guest lecture, annual meeting of Israeli Chemistry Teachers,

held in Rehovoth, December, 2003.

32. “Science in the Courtroom”, featured after-dinner speaker, annual awards dinner, Applied Materials

Corporation, Tel Aviv, January, 2004.

33. “Polymorphism and Analytical Chemistry”, invited lecture presented at annual meeting of the

Analytical Chemistry Section, Israel Chemical Society, Kfar Maccabiah, January, 2004.

34. “Patents and Polymorphism: A Chemist’s View” presented at the Fifth Symposium on Polymorphism

and Crystallization, organized by Scientific Update, New Orleans, Louisiana, March , 2004.

35. “Polymorphs and Patents: A Chemist’s View”, presented at the IQPC conference on Polymorphism

& Crystallisation”, London, April, 2004.

36. “Polymorphism and Patents”, Plenary Lecture, presented at at the 35th Course, International School

of Crystallography on Polymorphs and Solvates, Erice, Sicily, June, 2004.

37. “Polymorphism and Crystal Structure Prediction”, presented at the American Crystallographic

Association Transaction Symposium, Chicago, July, 2004.

38. “Hydrogen Bonds, Graph Sets and Crystal Engineering”, presented at the American Crystallographic

Association Transaction Symposium, Chicago, July, 2004.

39. “Recent Adventures in Polymorphland”, presented at the Midwest Regional Meeting of the American

Chemical Society, to be held in Manhattan, Kansas, October, 2004.

40. “Polymorphs and Patents: Some Recent Litigations”, presented at the IQPC conference on

Polymorphism & Crystallisation”, Frankfurt, Germany, October, 2004.

41. “Polymorphs and Patents: The Chemist as a Litigation Witness”, presented at the Pittcon Congress

on Analytical Chemistry, Orlando, Florida, February, 2005.

42. “Polymorphism in Crystals: Current Challenges and Developments”, presented at the IQPC

conference on Polymorphism & Crystallisation”, London, February, 2005.

43. “Polymorphism in Crystals: Current Challenges and Developments”, presented at the IQPC

conference on Polymorphism & Crystallisation”, Philadelphia, March,


28

44. “Recent Adventures in Polymorphland”, presented at the workshop on Crystal Engineering, Collegio

Superiorie, Universita di Bologna, Bologna, May, 2005.

45. “Polymorphism and Crystal Engineering – A Contradiction in Terms?, presented at the annual

meeting of the American Crystallographic Association, Orlando, FL, May, 2005.

46. “Chemistry in the Courtroom”, presented at Symposium honoring Prof. Roland Boese on his 60th

birthday, Essen, German, June, 2005.

47. “Recent Adventures in Polymorphland”, presented at Molecular Crystal Engineering EuroConference

on Evaluations and Predictions of Solid State Materials Properties, Helsinki, Finland, June, 2005.

48. “Reminiscences of Noncentrosymmetric Crystals”, presented at the Microsymposium on

Noncentrosymmetric and Chiral Crystals at the XX Congress and General Assembly of the

International Union of Crystallography, Florence, Italy, August, 2005.

49. “Recent Adventures in Polymorphland”, presented at the annual meeting of the Spanish Royal

Society of Chemistry, Lugo, Spain, September, 2005.

50. “Graph Sets, Co-crystals and Polymorphs”, presented at the annual meeting of the Spanish

Crystallographic Society, Lugo, Spain, September, 2005.

51. “Polymorphism in Crystals: Current Challenges and Developments”, presented at the German

Pharmaceutical Association Conference on Polymorphism & Crystallisation”, Darmstadt,

November, 2005.

52. “Chemical, Analytical and Evidentiary Issues Present in Cases: Important Considerations on

Polymorph Cases from a Testimonial Perspective by an Expert Witness”, presented at the IQPC

conference on “Developing IP Strategies for Crystalline Forms”, London, December, 2005.

53. “Polymorphism & Crystallisation: Developments & Future Directions”, to presented at

Polymorphism & Crystallisation 2006, London, March 2006

54. “Chemistry in the Courtroom”, Shariv Annual Memorial Lecture, Makhteshim Chemicals, Beer

Sheva, March, 2006. 55. “Co-crystals – An Overview”, presented at the IQPC Symposium on

Polymorphism & Crystallisation 2006, London, March 2006.

56. “Co-crystals and Crystal Engineering”, presented at the annual meeting of the American

Crystallographic Association, Honolulu Hawaii, August, 2006.

57. “Polymorphs and Patents”, presented at EPDIC 2006, Geneva, August, 2006

58. “Polymorphism and Crystal Engineering”, presented at the Fifth Indaba on Chemical

Crystallography”, Krueger National Park, South Africa, August, 2006.

59. “Structure-Property Relations in Crystals”, presented at the 23rd

European Crystallography Meeting,

Leuven, Belgium, August 2006.

60. “The Role of the Expert Witness and Their Perspective on Polymorph Cases”. Presented at the IQPC

Symposium on Developing IP Strategies for Crystalline Forms”, London, December 2006.


29

61. “Can Co-crystals be Assembled Employing a Specific Hydrogen-Bond Motif?” Presented at M3:

Molecules, Material, Medicines, an International Conference on the Role of Materials Science and

Engineering in Drug Development” Reykjavik, Iceland, May, 2007.

62. “Polymorphism – Fundamentals” and “Polymorphism – Applications”, Two plenary lectures,

presented at at the 39th Course, International School of Crystallography on Crystal Engineering for

New Materials Properties, Erice, Sicily, June, 2007.

63. "Polymorphism and Supercritical Fluids", presented at the 11th European Meeting on Supercritical

Fluids in Barcelona, May, 2008.

64. "Present at the Creation – 20 Years of MWOSSC", Keynote address presented at the 20th Midwest

Organic Solid State Chemistry Meeting, Manhattan, Kansas, June, 2008.

65. "Polymorphism and Co-crystals", presented at the 20th Midwest Organic Solid State Chemistry

Meeting, Manhattan, Kansas, June, 2008.

66. Guest lecturer, International Masters Course on Intellectual Property, held in Bologna, Italy, July,

2008 (~15 hours of lectures on patent preparation and litigation in the pharmaceutical industry)

67. "Understanding and Controlling Polymorphism", invited microsymposium talk at the Congress of the

International Union of Crystallography held in Osaka, Japan, August 2008.

68. Invited plenary lecture, “Crystal Forms and Intellectual Property”, presented at the International

School on Crystallization: Agrochemicals, Drugs and Foods, Granada, May, 2009.

69. Invited (opening) lecture, “Recent Adventures and Misadventures with Polymorphs and Co-crystals”,

presented at the 4th Bologna Symposium on Crystal Forms, Bologna, June 2009.

69. Invited lecture, Microsymposium on Crystal Engineering, annual meeting of the American

Crystallographic Association, Toronto, Canada, July, 2009.

70. Keynote lecture, Congress of the International Union of Pure and Applied Chemistry,

Glasgow, Scotland, August, 2009.

71. Invited plenary lecture, “Crystal Forms and Intellectual Property”, presented at the International

School on Crystallization: Agrochemicals, Drugs and Foods, Granada, May, 2010.

72. University of Western Australia Professor-at-Large Public Lecture, “Chemistry in the Courtroom”,

presented in Perth, July, 2010.

73. “The Importance of Patents: IP Litigation in the Pharmaceutical Industry”, presented with Todd Shand

(Wrays) under the auspices of the Intellectual Property Research Institute of Australia (IPRIA)

The University of Melbourne. Presented in Perth, Adelaide, Melbourne and Sydney, August 2010.

74. “Powders and Pharmaceuticals”, to be presented at the NATO Advanced School on X-ray Powder

Diffraction held in Erice, Sicily, June, 2011.

75. “Chemistry in the Courtroom”, Annual awards dinner address, Royal Australian Institute of

Chemistry, Western Australia Chapter, Perth, July, 2011.

76. “Searching the Crystallographic Literature & Evaluating Structures”, International course in X-ray

crystallography, University of Western Australia, Perth, July 2011.


30

77. “The Shroud of Turin – What Can Science Tell Us?”, Public Lecture, Institute of Advanced Studies,

University of Western Australia, Perth, July 2011.

78. “Chemistry in the Courtroom”, Annual Networking Event, Vertex Pharmaceuticals, Cambridge, MA,

November, 2011.

79. “More Adventures in Polymorphland”, to be given at the 6th

Bologna Conference on Crystal Forms,

Bologna, Italy, January 2011.

80. “Polymorphism and Crystal Engineering”, plenary lecture to be given at the 2nd

Gordon Conference

on Crystal Engineering, Waterville Valley, NH, June 2012.

81. “Polymorphism of Drugs: Theory, Experimental Techniques and Patent

Litigations”, to be given at the “Insubria International Summer School on

Crystallographic Techniques for Health and Biosciences” at the University in Como, June 18 to 23,

2012, Como, Italy.

82. “Polymorphism in Pharmaceuticals”, a series of lectures to be given at the advanced school for

pharmaceutical sciences, Florianopolis, Brasil, August 2012.


31

(b) Presentation of papers at conferences/meetings (since 1995)

1. "New Pyridinium Substituted TTF Derivatives. A Route Towards Single Component Conducting LB

Films"

O. Paztal-Levi, V. Khodorkovsky, J.Y. Becker and J. Bernstein

Presented at the 60th Annual Meeting of the Israel Chemical Society, Rehovoth, February, 1995.

2."Synthesis and Properties of Bis(Tetrathiafulvalenyl)"

Hagit Gershtman, V. Khodorkovsky, J.Y. Becker and J. Bernstein


3. "Generation and Trapping of New Intermediates Involving 1,4-dithiabutadiene Moiety: A New

Approach Towards Multisulfur Substituted Tetrathiafulvalenes"

E. Aqad, V. Khodorkovsky, J.Y. Becker , A. Ellern and J. Bernstein


4. "Conformational Studies of the p,m-Dihalo Substituted Benzylideneaniline System'

O. Navon, J. Bernstein and S. Zamir


5. "Graph Sets and Hydrogen-Bond Functionality. Recent Developments"

J. Bernstein and R. Davis

Presented at 16th European Crystallographic Meeting - ECM 16, Lund, Sweden, August, 1995.

6. "New Pyridinium Substituted TTF Derivatives: A Route towards Single Component Conducting LB Films,

O. Paztal-Levi, V. Khodorkovsky, J.Y. Becker and J. Bernstein

Presented at the 61st Meeting of the Israel Chemical Society, Jerusalem, February, 1996.

7. "Synthesis and X-ray Structure of TTFI4"

H. Gerhstman, J.Y. Becker, J. Bernstein, A. Ellern and V. Khodorkovsky


8. "Graph Sets and Hydrogen Bond Functionality"

C. Sharabi and J. Bernstein


9. "Intermolecular Interactions: A Five Membered Ring Pattern Containing Halogen...Halogen

Hydrogen Interactions"



10. "Hydrogen-Bond Pattern Functionality and Graph Sets"

J. Bernstein

Presented at the XVII Congress and General Assembly, International Union of Crystallography,

Seattle, Washington, August 1996

11. " Intermolecular Interactions. A Five-Membered Ring Pattern Containing Halogen...Halogen and

Halogen ...Hydrogen Interactions"


Presented at the XVII Congress and General Assembly, International Union of Crystallography,

Seattle, Washington, August 1996


32

12. "Iodo Substituted Tetrathiafulvalenes: Synthesis, X-ray Structures and Conducting Properties"

J.Y. Becker, J. Bernstein, A. Ellern, H. Gershtenman, V. Khodorkovsky, L. Shapiro and C.-S. Wang

Presented at the International Conference on Science and Technology of Synthetic Metals,

ICSM, Snowbird, Utah, August, 1996.

13. “Disappearing Polymorphs”

J.-O. Henck and J. Bernstein

Presented at Xth Symposium on Organic Crystal Chemistry (OCC-97) held

in Rydzyna, Poland, August, 1997.

14. “Disappearing Polymorphs”


Presented at the 17th European Crystallographic Meeting, Lisbon, August, 1997.

15. “Polymorphism of 5,5’ - Diethylbarbituric Acid (Barbital)

O. Navon, J. Bernstein and J.C. MacDonald

Presented at the 17th European Crystallographic Meeting, Lisbon, August, 1997

16. “Synthesis and Properties of Unsymmetrically Substituted Tetrathiafulvalene Involving 1,4-Dioxane

Moiety”

P. Krief, J. Becker, J.Bernstein, V. Khodorkovsky

Presented at the NATO Advanced Research Workshop on Supramolecular Engineering of Synthetic

Metallic Materials: Conductors and Magnets, Sitges (Barcelona), Spain, January, 1998.

17. “Disappearing and Reappearing Polymorphs”

J.-O. Henck and J. Bernstein

Presented at the NATO Advanced Study Institute and Euroconference, the 27th International School

of Crystallography, Erice, Sicily, Italy, May, 1998

18. “Disappearing and Reappearing Polymorphs”

J. Bernstein, J.-O. Henck and A. Ellern

Presented at XVIII Congress and General Assembly of the

International Union of Crystallography, Glasgow, Scotland, 1999.

19. “Polymorphism of Barbitals”


Presented at XVIII Congress and General Assembly of the

International Union of Crystallography, Glasgow, Scotland, 1999.

20. “Solid State Investigation of the Polymorphic System of Butethal (5-ethyl-5-N-butyl barbituric

acid)”


Presented at the 19th

European Crystallographic Meeting, Nancy, France, August, 2000.

21. “Crystal Polymorphism of Bromhexine Hydrochloride”

U.J. Griesser, M.E. Auer, A. Ellern, N. Molitor, J. Bernstein and A. Burger

Presented at the Annual Meeting of the American Pharmaceutical Association, Indianapolis,

November, 2000.


33

22. “Groth’s Original Concomitant Polymorphs Revisited”


Presented at the XIX International Union of Crystallography, Geneva, Switzerland, August 2002.

23. “Concomitant Polymorphs: Diaminobenzenesulfonic Acids”

J. M. Rubin and J. Bernstein

Presented at the XIX International Union of Crystallography, Geneva, Switzerland, August 2002.

24. “The Polymorphism of Ethambutol”

J. Rubin-Preminger and J. Bernstein

Presented at the 21st European Crystallographic Meeting, Durban, South Africa, August, 2003.

25. “Groth’s Concomitant Polymorphs Revisited”


Presented at at the 35th Course, International School of Crystallography on Polymorphs and Solvates,

Erice, Sicily, June, 2004.

26. “Serendipitous Discovery of Four Polymorphs of Benzidine”


Presented at the XX Congress and General Assembly of the International Union of Crystallography,

Florence, Italy, August, 2005.

27. “Jumping crystals”: Structural aspects of the thermosalient phenomenon (oral)

Željko Skoko, Sharona Zamir, Panče Naumov, Joel Bernstein

The 10th

Conference of the Asian Crystallographic Association, BEXCO, Busan, Korea, October 31

– November 3, 2010.

28. “The lowest energy calculated structure of acridine has been found”

Einat Schur, Joel Bernstein, Louise S. Price , Peter W. Stephens, Saul H. Lapidus

Presented at XXII Congress and General Assembly, International Union of Crystallography, Madrid,

Spain, August, 2011


34

SEMINARS AT ACADEMIC AND RESEARCH INSTITUTIONS (since 1978)

1978

Chemistry Department, University of Louisville, Louisville, Kentucky

Department of Chemistry, University of Kentucky, Lexington, Kentucky

Department of Chemistry, Georgia Institute of Technology, Atlanta, Georgia

Department of Chemistry, University of Minnesota, Minneapolis, Minnesota

Department of Pharmacy, Purdue University, Lafayette, Indiana

1979

Department of Chemistry, Adelphi University, Garden City, New York

Department of Chemistry, University of Massachusetts, Boston, Massachusetts

Department of Chemistry, University of Rhode Island, Kingston, Rhode Island

Chemistry Department, University of Cincinnati, Cincinnati, Ohio

Ceramic, Glass and Solid State Science Division, U.S. National Bureau of Standards, Washington,

D.C.

1980

Faculty of Chemistry, Weizmann Institute of Science, Rehovoth

Technical Forum, 3M Company, St. Paul, Minnesota

Department of Chemistry, Lehigh University, Bethlehem, Pennsylvania

1981

Department of Chemistry, Brandeis University, Waltham, Massachusetts

1983

Department of Chemistry, Clarkson College of Technology, Potsdam, New york

Institute of Structural Chemistry, National Research Council of Italy, Rome

Institute of Chemistry, University of Bologna, Bologna, Italy

Department of Chemistry, University of Modena, Modena, Italy

1984

Medical Foundation of Buffalo, Buffalo, New York

Department of Chemistry, University of Delaware, Newark, Delaware

Smith Kline & French Laboratories, Philadelphia, Pennsylvania

Science Research Labs, 3M Center, St. Paul, Minnesota

Faculty of Chemistry, The Technion, Haifa

1985

Department of Chemistry, University of Nebraska, Lincoln, Nebraska

Department of Chemistry, New Jersey Institute of Technology, Newark, New Jersey

Central Research Laboratories, E.I. duPont de Nemours, Wilmington, Delaware

1987

Department of Chemical Physics and Electrochemistry, University of Milan, Italy

Department of Pharmacy, School of Medicine, Hebrew University, Jerusalem

Institute of Chemistry, University of Bologna, Bologna, Italy

1988

Department of Radiopharmacology, Nuclear Research Center, Nahal Soreq, Israel

Department of Materials, Weizmann Institute of Science, Rehovoth, Israel

Teva Pharmaceuticals, Petah Tikva, Israel


35

1989

Biosym Technologies, La Jolla, California

Department of Chemistry, University of Wisconsin, Madison

Materials Sciences, University of Nebraska, Lincoln

Department of Chemistry, Jageollonian University, Cracow, Poland

1990

Department of Organic Chemistry, Weizmann Institute of Science, Rehovoth, Israel

1991

Teva Pharmaceuticals, Kfar Saba, Israel

Department of Physical Chemistry and Electrochemistry, University of Milan, Italy

Hungarian Academy of Sciences, Budapest, Hungary

TAMI, Institute of Applied Research, Haifa, Israel

Chemistry Colloquium, Faculty of Chemistry, The Technion, Haifa

1992

Department of Chemistry, Cambridge University, Cambridge, England

1993

Teva Pharmaceuticals, Petah Tikvah, Israel

Department of Chemistry, University of Texas, Austin, Texas

1995

Department of Chemistry, Tel Aviv University

Department of Crystallography, Utrecht University, The Netherlands

1996

Department of Chemistry, University of Copenhagen

1997

Department of Organic Chemistry, Hebrew University of Jerusalem

Department of Inorganic Chemistry, University of Barcelona (July and September)

Cambridge Crystallographic Data Centre, Cambridge, England

1998

Department of Chemistry, University of Birmingham

Department of Crystallography, Birkbeck College, University of London

Department of Chemistry, University of Cambridge

Marketing Group, Royal Society of Chemistry

1999

Nuclear Research Centre – Negev (Israel)

Teva Pharmaceuticals

Rand Afrikaans University

University of Witwatersrand

Simmons College

Department of Chemical Engineering, Ben-Gurion University of the Negev


36

2000

Department of Chemistry, Technical University of Denmark

Nuclear Research Centre – Negev (Israel)

Beer Sheva Forum of Engineers

Yale University

Technion – Israel Institute of Technology

BASF Ludwigshafen, Germany

2001

Teva Pharmaceuticals

2002

University of Geneva

Hebrew University of Jerusalem

2003

Kellogg-Recanati HTMB Tel Aviv University

Makhteshim Chemical Works

2004

Brandeis University

Worcester Polytechnic Institute

Kellogg-Recanati HTMB Tel Aviv University

Eli Lilly & Co. (two seminars)

University of New Mexico

Aventis Pharmaceuticals

University of Frankfurt

2005


Alfa-Wasserman Pharmaceuticals, Bologna

University of Barcelona

University of Witwatersrand

University of Stellenbosch

University of Capetown

Johnson & Johnson Company, Beerse, Belgium

Taro Pharmaceuticals, Haifa

2006

University College London

2007


2009

SSCI-Aptuit, West Lafayette, Indiana

New Mexico Highlands University (3)

New York University

Australian National University (3)

Australian Nuclear Research Institute


37

2010

University of Western Australia

Osaka University (2)


38

EDITORSHIP OF COLLECTIVE VOLUMES AND SCIENTIFIC JOURNALS

Guest editor (with J. Becker and S. Bittner), special issue of the Israel Journal of Chemistry on "The

Chemistry of Organic Conducting Materials", Volume 27, No. 4 (1986). (Actual date of

publication, 1987).

RESEARCH GRANTS

External funding

1. Israel Academy of Sciences, 1977-1979, approx. $15,000/year for "Studies in Conformational

Polymorphism".

2. United States-Israel Binational Science Foundation, 1978-1981, Approx. $12,000/year for "Studies in

Conformational Polymorphism" (American collaborators: I.C. Paul, University of Illinois and C.J.

Eckhardt, University of Nebraska).

3. Israel Academy of Sciences, 1981-1983, approx. $12,000/year for "Non-bonded Interactions in

Organic Chalcogen Compounds".

4. Israel Academy of Sciences, 1983-1986, approx. $20,000/year for "Design, Preparation and

Characterization of Organic Conductors" (with J. Becker, S. Bittner and S. Shaik).

5. United States-Israel Binational Science Foundation, 1984-1987, approx. $25,000/year for "Structure-

Property Relationships in Organic Solids" (American collaborator: C.J. Eckhardt, University of

Nebraska).

6. Wolf Foundation (Israel), 1983-1985, approx. $15,000/year for "Organic Metals"(with J. Becker, S.

Bittner and S. Shaik). Note: this was the only grant awarded by the Foundation in 1983.

7. Hasselblad Foundation (Sweden), 1985-1987, (SK 323,000) for "Conducting Organic Materials",

(with J. Becker, S. Bittner and S. Shaik).

8. Joint Committee on Powder Diffraction Standards, 1985-1986, $4550; 1986-1987, $5000; 1987-

1988, $5900; 1988-89, $7000; 1989-1990, $12,000 ; 1990-1991, $10000; 1991-92, $12,500; 1992-

93, $13,500; 1993-94, $10,000, for "Polymorphism in Pharmaceutically Important Materials" (with

L. Zevin).

9. National Council for Research and Development - Joint German/Israeli Research Program, 1987-

1989, DM 310,000, for "Electrically Conducting Organic Materials", (with J. Becker, S. Bittner and

S. Shaik) (German collaborator, Prof. M. Hanack, University of Tubingen).

10. Council on Higher Education-Planning and Budget Committee, 1986-87, $129,000 for

computerizing teaching laboratories, (with Y. Band, S. Efrima, R. Glaser and D. Kost for the

Department of Chemistry).

11. United States - Israel Binational Science Foundation, 1987-1991. $24,500/yr for "Environmental

Influences on Molecular Conformation and Physical Properties of Drugs". (American collaborator:

Prof. M. C. Etter, University of Minnesota).


39

12. United States Army European Office of Research, 1988-1991. $89,000 for "Electrically Conducting

Materials: Design, Synthesis and Characterization", (with J. Becker, S. Bittner and S. Shaik).

13. Israel Ministry of Science and Technology, under program for absorption of new immigrants

1991-1994. 50,000 NIS for "New Donors for Organic Conductors", with J. Becker.

14. Israel Academy of Sciences 1992-1995. $18,500/year for "Hydrogen-Bond Patterns in Organic

Crystals"

15. European Community-Israel Cooperation Scheme 1994-1996, 180,000 ecu for "New Electrially

Conducting Organic Materials: Design, Synthesis and Characterization" with M. Hanack, Tubingen,

Germany and N. Martin and C. Seoane, Madrid, Spain.

16. German Israeli Foundation for Scientific Research and Development 1995-1998, DM 450,000, for

"Algebraic Graph Theory and Its Application in Mathematical Chemistry" with M. Klin (BGU), R.

Poschel (Technical University, Dresden), G. Tinhofer (Technical University, Munchen), G. Adel'son-

Vel'skii (Bar-Ilan University).

17. United States - Israel Binational Science Foundation 1995-1998, for "Chemical Diversity of

Hydrogen-Bond

Patterns and Functionality"; $19,500 for first year. U.S. Collaborator: Raymond E. Davis, University

of Texas at Austin

18. Israel Science Foundation (administered by the Israel Academy of Sciences), 1995. $25,000

equipment grant for

a solid state CP-MAS (cross polarization magic angle spinning) NMR probe. With Robert Glaser,

Daniel Kost and Moshe Gottlieb.

19. Israel Science Foundation (administered by the Israel Academy of Sciences), 1997, $140,000

equipment grant for a variable temperature X-ray diffractometer (total purchase $500,000). With

David Chipman, Shoshana Arad and Moshe Gottlieb.

20. Austria-Israel Exchange Program, 1998-1999. Funds for two visits in each direction per year for two

years. With Drs. Jan-Olav Henck and Ulrich Griesser, Institute of Pharmacognosy, University of

Innsbruck.

21. United States - Israel Binational Science Foundation 1999-2002, for "Concomitant Polymorphs";

~$30.000/yewar for three years. U.S. Collaborator: James Chickos, University of Missouri at St.

Louis.

22. Rand Afrikaans University – Ben-Gurion University of the Negev cooperation scheme 2003-2005

for “Studies in Polymorphism”. South African Collaborator: Prof. Gert Kruger.

23. United States - Israel Binational Science Foundation 2005-2009, for " Crystal Design and

Engineering Utilizing Geometry-Specific Interactions "; ~$50.000/year for four years. U.S.

Collaborator: Peter Stephens, SUNY Stony Brook.

Internal funding

University Research Fund, 1980, $5500 for the purchase of a Mettler microscope hot stage.

Rector's Discretionary Research Funds, 1981, $8000 for "Organic Metals" (with J. Becker, S.Bittner

and S. Shaik).


40

RESEARCH STUDENTS AND POSTDOCTORALS

(all at Ben-Gurion University)

Postdoctorals:

Avi Maltz (1979-81) - Owner and Director, Private Analytical Laboratories, Tel Aviv

Eliezer Aharon-Shalom (1982-84) - Laboratory Director, Agis Pharmaceuticals, Yeroucham

Reiko Kuroda (1981) - Professor, University of Tokyo

J.A.R.P. Sarma (1987-88)- Senior Scientist, Indian Institute of Chemical Technology, Hyderabad

Vladimir Khodorkovsky, (1991-93). Professor, Ben-Gurion University of the Negev

Arkady Ellern, 1993-1996. Departmental Service Crystallographer, Iowa State University

Jan-Olav Henck, 1996 - 1997 (Alexander von Humboldt Fellow), Director of Chemical Sciences

SSCI/Aptuit, West Lafayette, Indiana

Andreas Lemmerer, 2008 – 2010. Lecturer, Univesrity of Witwatersrand, Johannesburg, South Africa

Graduate Students:

Haya Regev, Ph.D. (1972-76) - Natural Sciences Librarian, BGU

Ilana Bar, M.Sc., Ph.D. (1974-82) – Professor of Physics, BGU

Ehud Goldstein, M.Sc. (1977-79) - Ph.D., Hebrew University, Lawyer – Environmental Affairs

Doron Mason, M.Sc.(1981-83) - (Ph.D. Hebrew University Mahkteshim Chemicals, Beer Sheva

Leah Shahal, (1985-92 ) - Ph.D. - Research Chemist, Tami Research, Haifa

Eli Harlev, (1986-1990 ), Ph.D., Director, Interdisciplinary Instrument Laboratory, Ben-Gurion

University

Sharona Zamir-Yakir, M.Sc., Ph.D., 1987 - 1995 Director, Pilot plant, Chimagis, Beer Sheva

Liat Shimony, (1990-92) M.Sc. Completed Ph.D. with Dr. Jenny Glusker, Fox Chase Institute for

Cancer Research, Philadelphia, Pennsylvania, U.S.A.

Yael Giron, M.Sc., 1995, Agis Chemicals

Oshrit Navon, (1993-2001), Ph.D., Science Teaching Unit, Weizmann Institute of Science

Carmit Sharabi, 1997, M.Sc.

Hadas Dadon, (1994-1996). M.Sc. student

Janice Rubin (2001-2005 ) Ph.D. , Minerva postdoctoral fellow, University of Aachen; Postdoctoral,

Tel-Aviv University, Currently at Dexxon Pharmaceuticals

Michal Rafilovich(2000 - 2006) M.Sc., Ph.D., Teva Pharmaceuticals

Einat Shur (2001 - 2003) M.Sc., Ph.D student

Sarah Wishkerman (2003- ) M.Sc. /Ph.D.student

Inna Barsky (2003- ) M.Sc./Ph.D. student

Mazal Wenger (2003-2008) Ph.D. , currently director, analytical laboratories, Bromine Compounds,

Israel, Ltd.

Zvicka Deutsch (2004-2007) M.Sc. student; currently Ph.D. student, Weizmann Institute

Sagi Eppel (2004-2007) M.Sc. student; currently Ph.D. student, Weizmann Institute

Aynav Katz (2007- ) Ph.D. student

joel bernstein november - bguin.bgu.ac.il/teva/chem/staffcv/joelbernstein.pdf · 1 joel bernstein...

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