August 2011

Joanne M. Hilden, MDCurriculum Vitae

Office Address Director of Clinical ServicesCenter for Cancer and Blood DiseasesAssociate Chief, Section of Pediatric Hematology/Oncology/BMTChildren’s Hospital Colorado13123 East 16th Street B115Aurora, CO 80045Phone 720 777-8857Fax 720 777-7279Joanne.Hilden@childrenscolorado.org

Education 1975-77 BS University of Minnesota (Medical Technology)1983-88 MD University of Minnesota School of Medicine, Mpls, MN1985-86 Pre-doctor fellowship in Immunobiology, lab of Dr. Fritz

Bach, University of Minnesota

Post-graduate and 1988-91 Pediatric Residency, University of MinnesotaFellowship Training Department of Pediatrics

1991-94 Fellowship, Pediatric Hematology/Oncology/BMT,University of Minnesota, Department of Pediatrics,Section of Hematology/Oncology/BMT

Faculty Appointments 1994-95 Instructor, Department of Pediatrics, University of Minnesota School of Medicine

1995-01 Assistant Professor, Department of Pediatrics,University of Minnesota School of Medicine

2004-07 Associate Professor, Department of Pediatrics,Cleveland Clinic Lerner College of Medicine at

Case Western University2009-11 Clinical Professor of Pediatrics, Cincinnati

Children’s Hospital, Cincinnati OH, affiliate of St. Vincent, Indianapolis

2011 Visiting Professor of Pediatrics, University of Colorado,Denver, CO

Hospital and other 1994-01 Staff Hematologist/Oncologist, St. Paul Children’s Professional Hospital, St. Paul, MinnesotaPositions 2001-07 Chair, Department of Hematology/Oncology, The

Children’s Hospital at The Cleveland Clinic.2001-07 Faculty, Taussig Cancer Center, Cleveland Clinic2001-07 Faculty, Brain Tumor Institute, Cleveland Clinic2002-07 Medical Director, Pediatric Palliative Medicine,

The Children’s Hospital at The Cleveland Clinic.

2008-11 Attending Physician, Hospice of the Western Reserve, Cleveland, OH

2007-11 Executive Medical Director, Peyton Manning Children’s Hospital at St. Vincent, Indianapolis, IN

2007-11 Attending Physician, Pediatric Hematology/Oncology

Joanne M. Hilden MD Curriculum Vitae 1

August 2011

2007-11 Medical Director, Pediatric Palliative Medicine, and attending Hospice Physician, Peyton Manning

Children’s Hospital, Indianapolis, IN2011 Director of Clinical Services, Center for Cancer and

Blood DiseasesAssociate Chief, Section of Pediatric

Hematology/Oncology/BMT. Children’s Hospital Colorado.

Honors, special 1979 BA in Medical Technology with High Distinction recognitions, and (class valedictorian)awards 1984-88 Medical School honors

University of MN Ruth Boynton Memorial ScholarshipUniversity of MN W. Boutell Memorial ScholarshipUniversity of MN Bell-Evans Book Award in Pathology,awarded to top student in pathology year 2 of SOM

1987 Alpha Omega Alpha1988 Minnesota Medical Foundation Undergraduate Research

Award1993 University of Minnesota Fellow Research Award1993-94 Clinical Fellow, American Cancer Society1994-95 ASCO Young Investigator Award2001 Faculty Scholar, Soros Project on Death in America2005-11 Best Doctors in America2006 Cleveland Clinic Spirit of Children’s Hospital

Chairman’s Award2006-07 Drexel University, Fellow, Executive Leadership in

Academic Medicine

Membership in Local SocietiesProfessional Minnesota State Commission on End of Life Care 2000-01Organizations American Cancer Society; Ohio Board of Trustees 2005-07

National SocietiesAmerican Academy of PediatricsAmerican Society of Pediatric Hematology/Oncology

Bylaws committee 2004-07Board of Trustees, elected, 2005-08Chair, Professional Development Committee 2010-Quality/Safety Institute working group 2011-

American Society of HematologyAmerican Society of Clinical Oncology

Task force on cancer care at the end of life 1997-00Ethics Committee 2002-05

American College of Physician ExecutivesAmerican Academy of Hospice and Palliative MedicineAmerican Board of Hospice & Palliative Medicine

National Hospice & Palliative Care Organization Pediatric State Leaders Policy Group: Indiana State Representative

2011

Joanne M. Hilden MD Curriculum Vitae 2

August 2011

Major committee National Scientific Committeesand serviceresponsibilities Children’s Oncology Group (COG):

Infant Acute Lymphoblastic Leukemia Committee (1953) Biology chair 1994 – 00

Infant ALL Task Force for Successor Protocol 1997-05Infant ALL 9407, Vice Chair 2004 - 07

Infant ALL, Chair of AALL0631 2005 - presentHigh Risk CNS PNET Committee (99701) 1996 - 07Infant Brain Tumor Protocol (99703) 1997 – 04Down Syndrome/AML Committee (A2971), Vice-Chair 1997-04Founder and Co-Chair, COG Palliative Care Subcommittee 1999-05Cancer Control Steering Committee 2000-05Member, Infant Brain Tumor Task Force 2000- 08Cancer Control Committee Liaison to Young Investigator Committee

2002-04Voting Body Steering Committee, (elected) 2005-07ALL Executive Committee 2006 – presentYoung Investigator Mentoring Program 2006-08Committee for treatment of CNS AT/RT ACNS0333 2008 – presentHigh Risk ALL Alternative Therapies Task Force: chair 2008-11Rhabdoid Tumor Working Group Oct 2010-presentHigh Risk ALL committee AALL1131 2011-

Institute of Medicine Committee on Care for Children Who Die and Their Families 2001-02

Advisory Board: National Advanced Illness Coordinated Care Program2000-02

National Consensus Project Advisory Council: Palliative Care Steering Committee 2002-04

National Pediatric Palliative and End-of-Life Care Leadership Group Co-Chair 2002-04

National Coalition for Cancer Survivorship: Advisory Panel for Essential Care 2003-04

National Academic CommitteesAccreditation Council for Graduate Medical Education: Advisory

Committee for Hospice and Palliative Medicine 2006-10Executive Leadership in Academic Medicine 2007-08

Alumni group 2008 -Appointed mentor for cohort 7 2008 –

UniversityCleveland Clinic Children’s Hospital, Chair, Search Committee Pediatric

Nephrology Section Head 2003-05Admissions Committee, Cleveland Clinic Lerner College of Medicine at

Case Western Reserve University 2003-04 Review Committee, Cleveland Clinic Immunology Chair 2003-04The Cleveland Clinic General Clinical Research Center (GCRC)

Joanne M. Hilden MD Curriculum Vitae 3

August 2011

Advisory Committee, M01 RR018390 from National Center forResearch Resources (NCRR), National Institute of

Health, 2003 Hospital and DepartmentChildren’s Health Care, Minneapolis and St. Paul, MN:

Culture Building Committee 1994-96Institutional Review Board 1994-01Task Force: “Dying Well in the Hospital” 1997-98

Hospital Advisory Board 1009-00

Cleveland Clinic (CC) Taussig Cancer Center Executive Committee 2001-03

CC Clinical Trials Scientific Review Committee 2002-03Cleveland Clinic Children’s Hospital (CCCH) Hospital Committee

2002-07CCCH Research Day Judge 2002-06CCCH Editor, Pediatric Perspectives 2003-06Cleveland Clinic Nurse-Physician Partnership Initiative for Magnet

Status: Pediatric physician representative 2003-04CCCH Strategic Planning Committee Core Group 2003-05CC Medical Records Committee 2004-5Cleveland Clinic (CC) World Class Service Rewards

& Recognition Team 2005-05CC World Class Service Team Leader 2005-07

Director/Manager Committee, Peyton Manning Children’s Hospital(PMCH) 2007-11PMCH Peer Review Committee 2007-11PMCH Quality/Safety Committee, Chair, 2007-11St. Vincent Indianapolis Hospital (SVIH) Medical Executive Committee

2007-11SVIH Medication Safety Committee, co-chair 2008-11SVIH Department Chairs Committee 2007-11SVIH Executive Peer Review Committee 2007-11SVIH Quality and Safety Committee 2007-11SVIH Physician Mentorship group 2007-11SVIH Building The Best: Mentor’s team 2009-11

Institutional National Initiatives and Committees:Ascension Health Children’s Healthcare Quality Initiative

Team leader: Medication Safety Collaborative 2010-11ABP Maintenance of Certification Project leader:

Ascension Ventilator-Associated Pneumonia 2010-8/11Ascension Bloodstream Infections 2010-11Ascension Optimization of Time to Antibiotics 2010-11

Community and National ServiceUS News & World Report/NACHRI: America’s Best Children’s

Hospitals Committees 2007-presentCancer committee 2007-10 (Chair 2010Appointed to Senior Advisory 2011 (one of 3 members)

Joanne M. Hilden MD Curriculum Vitae 4

August 2011

Licensure andBoard Certification

Board Date ofBoard Certification Certificate # Certification

American Board of Hospice & Palliative Medicine 1800 1/01American Board of Medical specialties: 12/08, exp 12/18 Hospice and Palliative MedicineAmerican Board of Pediatric Hematology/Oncology 1109 2/95; recert 5/00, 10/08, exp

12/15American Board of Pediatrics 46820 11/91; recert 11/05; exp 12/12Diplomate, National Board of Examiners 340279 7/89

Date of Issue Expiration

Colorado 8/2011Indiana 6/30/07 6/30/12

Inventions, intellectual property, and patents: none

Review and referee Editorial Board: work Journal of Clinical Oncology, 2006-09

Co-editor, Child & Adolescent Psychiatric Clinics of North America, “Pediatric Palliative Medicine,”

2006Ad hoc reviewer for:Journal of Pediatric Hematology/OncologyBloodCancerJournal of Clinical OncologyPediatric Blood & CancerJournal of PediatricsJournal of the American Medical AssociationJournal of Palliative Medicine

Special work on “Palliative Review Series,” 2005Institute of Medicine

Current Oncology Reports, Pediatric Section Editor, 2003-05

Abstract reviewer for 2003 Pediatric Academic Societies Annual Meeting 2003.

Reviewer: Senate/Congressional Draft Palliative Care Legislation for Kennedy, DeWine, and Pryce, 2003.

Scientific Review Council; Grant Reviewer : St. Baldrick’s Grants (for pediatric cancer, $25M/year, 2007 – present

Joanne M. Hilden MD Curriculum Vitae 5

August 2011

Invited Local and regionallectures, presentations, 1. Quantum Home Heath Services Nursing Continuing Education Series: and visiting “Follow-Up Care of Bone Marrow Transplant Patients,” Mpls MN 1992professorships 2. Oncology Nursing Society Annual Meeting, Duluth, MN: “Overview

of Pediatric Oncology,” 19963. American Cancer Society Nursing Conference: “Pediatric Oncology,” Mpls. MN 19974. Nursing Education Conf: “The Special Needs of the Adolescent

Oncology Patient,” Riverwood Healthcare Ctr, Aitkin, MN 19975. Topics and Advances in Pediatrics Peds CME: “Lunch With the

Professor,” Pediatric Oncology, St. Paul and Mpls Children’s 1997

6. Family Medicine Grand Rounds: Leukemia in Infants, Children, and Adolescents. St. Mary’s Medical Ctr, Duluth MN. 1997

7. Association of Pediatric Oncology Nurses Annual Conference, Mpls, MN: Ethics in Pediatric Oncology Care, 1998

8. University of Minnesota Grand Rounds: Hemophagocytic Lymphohistiocytosis, 1998

9. Children’s Hospitals & Clinics Grand Rounds: Hospice and High-Tech? The Ethics of Ventilators, Trachs, and Life Support

Technology in Hospice Care, Mpls. MN 199810. Children’s Hospitals & Clinics Grand Rounds: “End-of-Life Care

Controversies: What about Pediatrics?,” Mpls. MN 200011. Augsburg College Symposium: “Reclaiming the Soul of Medicine.” Breakout Session: “How to Survive Caring for Dying Children and

Adults,” Mpls MN 200012. Children’s Hospitals & Clinics of MN Grand Rounds: “Stem Cell

Rescue in Peds Malignancy” Mpls MN 200013. Cleveland Clinic Pediatric Grand Rounds: “Pediatric Oncology:

Sources of Success and Future Trends,” Cleveland, OH 200114. Pediatric Grand Rounds, The Children’s Hospital for Rehabilitation:

“Palliative Care for Children: It’s Time,” Cleveland, OH June 2002

15. Internal Medicine Grand Rounds, The Cleveland Clinic: “Pediatric Palliative Medicine,” Cleveland, OH, 2002

16. Lorain Family Health Center: “Pediatric Palliative Care,” Loraine, OH Oct 2002

17. Brain Tumor Institute Retreat, The Cleveland Clinic Foundation: “Pediatric Brain Tumor Rerview” 2002.

18. Fairview Family Practice Conference, Fairview Hospital: “Pediatric Palliative Care Issues,” Cleveland, OH 2002

19. Children’s Hospital for Rehabilitation, The Cleveland Clinic “Shelter from the Storm: Caring for a Child with a Life-

Threatening Condition.” 200320. Cleveland Clinic Primary Care Physician Partnership Series:

Advancement in Pediatric Care. “Cancer in the Child & Adolescent: Presentation & Diagnosis in the Era of Molecular Genetics – What Should the Primary Care Physician Know?,” 2003

21. The Cleveland Clinic Beachwood Family Health Center, Pediatric

Joanne M. Hilden MD Curriculum Vitae 6

August 2011

Conference: “Cancer in the Child & Adolescent: What Every Primary Care Physician Should Know,” 2003

22. Association of Pediatric Oncology Nurses Ohio Spring Meeting, Cleveland OH, 4/03

23. Family Medicine Conf: “Adolescent Cancer,” Independence OH 2003

24. Case Weatherhead Professional Fellows Society: “Palliative Care for Grown-ups and for Children,” Case Western University, Cleveland, OH

200325. Children’s Hospital at The Cleveland Clinic Pediatric Grand

Rounds: “Outcomes in Childhood Malignancies” 200426. Palliative Medicine in the 21st Century: From Art to Science:

Cleveland Clinic Children’s Hospital Regional Pediatric Conference (organizer and speaker). “Pediatric Palliative Medicine: State of the Science” Cleveland, OH 2004.

26. The Cleveland Clinic Brain Tumor Institute: “Pediatric Brain Tumors” 2004

27. Cleveland Clinic Pediatric Grand Rounds “Medication Safety and errors: Process analysis, blame-free reporting, and talking to

parents” 200428. The Cleveland Clinic Medical Division Grand Rounds: “Cancer at

the Interface of Pediatric and Medical Oncology: Striving to Understand and Improve Outcomes” 2005

29. Hillcrest Hospital Pediatric Grand Rounds: “Pediatric & Young Adult Brain Tumors: A New Era in Diagnosis & Treatment,”

Mayfield Heights OH 200630. Cleveland Clinic Children’s Hospital Grand Rounds: “Morbidity and Mortality of Transfusion Practice,” 200631. Family Medicine Grand Rounds: “Adolescent and Young Adult

Oncology: Update on Outcomes for Cancer” Willoughby Hills, OH 2006

32. The Cleveland Clinic Division of Pediatrics Research Seminar: “Acute Lymphoblastic Leukemia: Translational Research, True

Bench to Bedside Story” 200633. The Cleveland Clinic Cancer Center Grand Rounds: “Translational

Research in Childhood Cancer: The MLL gene: bench to bedside in Infant ALL in 20 years,” 2006.

34. Fairview Hospital Family Medicine Grand Round: “Pediatric Hematology/Oncology Update” Cleveland OH 2006.

35. Hillcrest Hospital Pathology Conference: “A case of stillbirth due to congenital leukemia.” Mayfield Heights, OH 2006

36. Pediatric Grand Rounds, Peyton Manning Children’s Hospital: Transfusion Medicine 2008

37. Eighth Annual PMCH Fall Pediatric CME Conference (Organizer) Speaker on: Measurable Outcomes in Pediatric Care.

Indianapolis, IN 200838. Midwest Pediatric Hospital Medicine Conference. Speaker and

Panelist: Forum on Hospital Medicine. Indianapolis, IN 200938. Ninth Annual PMCH Fall Pediatric CME Conference (Organizer)

Speaker on: Quality and Safety in Pediatric Care. Indianapolis, IN 2009 39. Pediatric Grand Rounds, Riley Children’s

Joanne M. Hilden MD Curriculum Vitae 7

August 2011

Hospital, Indiana University Indianapolis: Pediatric Palliative Care. IN 2009

40. St. Vincent Pediatric Grand Rounds: Pediatric Palliative Medicine; Current Topics and Literature Review 2011

Joanne M. Hilden MD Curriculum Vitae 8

August 2011

National1. Society for Pediatric Pathology Annual Meeting: Symposium on

current topics in pediatric hematopathology: Molecular Biology of Infant Leukemias, Mpls MN 1997

2. EPEC Trained: Education of Physicians in End-of-Life Care Train the Trainers Session, Chicago, IL. Presentation of (and

originator of) EPEC Pediatric Content, 19993. Merit Care Roger Maris Cancer Center Symposium on Primary Care

and Cancer: “End-of-Life Care Issues in Pediatric Oncology,” Fargo ND 2000

4. National Cancer Policy Board: “End of Life Care in Pediatric Oncology,” Cape Cod, MA July 2001.

5. National Soros PDIA Palliative Medicine Annual Meeting: “A Medical Triumph in Childhood Acute Lymphoblastic

Leukemia,” “How to Talk to Children (about Adults) and Adults (about Children),” and two workshops on “Understanding Children’s Grief,” Lake Tahoe NE 2002

6. Children’s Oncology Group Spring Meeting, Nursing Discipline Plenary Session: “Pediatric Oncology and Palliative Care,”

Tampa FL 20027. Children’s Oncology Group Spring Meeting, Hematology/Oncology

Discipline Committee: “Palliative Care and Phase I Therapies,” Co- presenter with Dr. Peter Adamson, Chair of Phase I Therapeutics. Tampa FL 2002

8. Visiting Professor, Children’s Hospital of Pittsburgh: 2002Pediatric Grand Rounds, “Pediatric Palliative Care: The Time has

Come.”Children’s Nursing Plenary Session: “Planning Pediatric Palliative Care

Service.”Resident Noon Lecture: Case Discussion on “Difficult Pediatric

Palliative Care Cases.”Tumor Board Conference: “Institute of Medicine Pediatric Palliative

Care Report Research and Clinical Care Recommendations.” 9. Pediatric Academic Societies Annual Meeting and joint ASPHO 1

5th Annual Meeting: “End-of-Life Palliative Care,” Baltimore, MD 2002

10. National Institute of Cancer Research/National Institute of Health: “Institute of Medicine Guidelines for Pediatric Palliative Care,”

Presenting for the IOM Committee on the Care of Children Who Die, Washington, DC 2002.

11. Children’s Oncology Group Fall 2002 Meeting: Neuroblastoma Developmental Therapeutics Panel. “Palliative Care Studies,” Dallas TX12. Scientific Reunion Symposium at The University of Minnesota Cancer Center; Biology and Therapy of Leukemias and Other Cancers: “Update on Infant Leukemia,” Minneapolis, MN 200313. Cleveland Clinic Pediatric National Board Review Symposium,

“Signs & Prognostic Factors of Common Pediatric Tumors,” Cleveland OH 2003

14. Visiting Professor, University of New Mexico Health Sciences Center, 2003:

Pediatric Grand Rounds, “Pediatric Palliative Care.”

Joanne M. Hilden MD Curriculum Vitae 9

August 2011

Geriatric Fellows Grand Rounds, “Grief in Children & Adolescents.”Neonatology Faculty/Fellows Meeting & Discussion, “Pediatric

Palliative Care.”15. Visiting Professor, Memorial Sloan-Kettering Cancer Center, New

York, 2003Pediatric Grand Rounds, Program start-up on “Pediatric Palliative Care.”Pediatric Fellows Luncheon & Informal Discussion on “Pediatric

Palliative Care.”16. ASCO Annual Meeting Education Session New Orleans, LA 2004. “Complementary & Palliative Care in the Treatment of Pediatric Cancer,” Invited session moderator, and speaker on: “Pediatric Palliative & Hospice Care: Definitions and Implementation

in Childhood Cancer Care” 17. American Academy of Hospice & Palliative Medicine’s Current

Concepts in Palliative Care: Update & Review Course: “Pediatric Issues in Hospice & Palliative Medicine,” Chicago IL 2004.

18. Cleveland Clinic National Pediatric Board Review Symposium: “Presenting Signs & Prognostic Factors of Common Pediatric

Tumors,” Cleveland OH 200419. American Society of Hematology Annual Meeting: “CCG 1953:

Acute Lymphoblastic Leukemia in Infants: Analysis of Prognostic Factors: A Report from the Children’s Oncology Group” Atlanta GA 2005

20. Annual Association of Pediatric Oncology Social Workers Conference: “Creating Hope for Tomorrow”: Compassionate &

Competent Practice in Pediatric Oncology Social Work” Speaker on Pediatric Pain Panel Norfolk, VA 2005

21. Visiting Professor, Schneider Children’s Hospital at North Shore: Irene Lefton Memorial Lectureship “Pediatric Palliative Care,”

Manhasset, NY, Dec. 200522. Cleveland Clinic National Pediatric Board Review Symposium:

“Presenting Signs & Prognostic Factors of Common Pediatric Tumors,” 2005

23. Visiting Professor, Aflac Cancer Center, Atlanta, GA 2005Tools for Living Symposium: Plenary Talk “Pediatric Palliative

Medicine” Breakout Session “Shelter from the Storm”Oncology lecture: “Infant Leukemia: Molecular Genetics &

Outcomes”24. Cleveland Clinic’s National Pediatric Board Review Symposium:

“Presenting Signs & Prognostic Factors of Common Pediatric Tumors,” 2006

25. Visiting Professor Montefiore Medical Center, Bronx, NY, 2006Pediatric Grand Rounds, “Pediatric Palliative Medicine: Integration into

Mainstream Health Care.”Palliative Care Team/Meeting and DiscussionResidents & Fellows/Humanistic Care DiscussionOncology Staff/ Meetings “Palliative Care” and “Infant Leukemia.”26. ASCO Education Session: Pediatric Palliative Medicine. Invited

session chair and speaker, Chicago, IL Speaker for: Pediatric

Joanne M. Hilden MD Curriculum Vitae 10

August 2011

Palliative Medicine and Decision-Making.” 2007.27. ASPHO Presidential Symposium; Invited Chair and organizer of

Session: Infant Leukemia: Epidemiology, Treatment, Biology. Speaker for: “How Should I Treat Infant ALL?” Toronto, Canada 200728. American Society of Pediatric Hematology/Oncology annual

meeting: Young Investigator Workshop: Grant Writing, and Ethical Dilemmas Encountered in Manuscript Preparation and Publication. San Francisco CA 2008

29. American Society of Pediatric Hematology/Oncology annual meeting: Moderator; Young Investigator Symposium: Contracts

and Negotiations, Finding Mentorship, and Work-Life Balance. Speaker: Contracts and Negotiations. San Francisco CA 2008

30. Families for Hope National Symposium on Holoprosencephaly annual national symposium: Making Difficult Decisions for

Your Child. Indianapolis, IN 200831. Visiting Professor Texas Children’s Houston TX 2009Research Symposium: Pediatric Palliative Medicine. Fellows’ symposium: “Lunch With a Leader” Baylor University. 32. American Society of Pediatric Hematology/Oncology annual

meeting: Young Investigator Symposium: Career pathways San Diego, CA 2009

32. American Society of Pediatric Hematology/Oncology 2010 Annual Meeting: Young Investigator symposium: Selecting your Path

and Taking the Critical First Steps Toward a Successful Career Montréal, Quebec, Canada 2010

33. American Society of Pediatric Hematology/Oncology 2010 Annual Meeting: Panel participant Career Development and Increasing

Diversity in Pediatric Hematology/Oncology. Montréal, Quebec, Canada 2010

International1. 15th International Congress on Care of the Terminally Ill: “When

Every Moment Counts: Pediatric Palliative Care,” Montreal, Quebec, 2004.

Teaching record Presentations to medical students, residents, and fellowsUnited Family Practice Resident Education Series: “Pediatric End-of-

Life Care: Goals of Therapy, and the Last Hours of Living,” St. Paul, MN Annual talk 2000 and 2001.

University of Minnesota Medical School Small Group Facilitator for the “Wit” Educational Initiative, 2001.

Pediatric Resident Noon Lecture, The Cleveland Clinic 2002-07:Monthly talk rotating topics:Childhood ALLGiving Medical Bad NewsPediatric Pain ManagementTransfusion Medicine

Cleveland Clinic Lerner College of Medicine Dean’s Dinner, Physician Scientist Series for Year 2 Medical Students:

Joanne M. Hilden MD Curriculum Vitae 11

August 2011

“Outcomes in Pediatric Oncology,” 2004.“My Life as a Physician Scientist” 2007

The Cleveland Clinic Pediatric Resident Special Lecture, “Humanism in Medicine,” 2006.

St. Vincent Indianapolis Pediatric, Family Medicine, OB/GYN, and Transitional Resident Noon Conference, 2007-11; Quarterly talk, rotating topics:Childhood ALLGiving Medical Bad NewsPediatric Pain ManagementTransfusion Medicine

Peyton Manning Children’s Hospital at St. Vincent, monthly Medical Director’s Morning Report: A Series on Professionalism 2009 – 11

Presentations to nursing students and practicing RNsUniversity of Minnesota Undergraduate Nursing Pediatrics Course:

“Issues in Death and Dying,” 2000Lecture for Chemotherapy Nurses, The Children’s Hospital at The

Cleveland Clinic: “What is Pediatric Palliative Care?” 2003

Ward/Clinic attending duties:1994-2001: St. Paul Children’s Hospital, affiliated with the University of Minnesota, Minneapolis, MNAttending physician 17 weeks/year on Pediatric Hematology/Oncology inpatient service. Supervision and bedside teaching of medical students, 1st, 2nd, and 3rd year pediatric and family medicine residents, and heme/onc fellows.

Three full day and two half day clinics/week; supervision and bedside teaching of 1 pediatric hematology/oncology fellow when rotating, supervision of residents and medical students at all times.

2001-2007 Cleveland Clinic Children’s Hospital, Cleveland, OH, and Cleveland Clinic Lerner College of Medicine at Case Western University, Cleveland, OH

Attending physician 7-10 weeks/year on Pediatric Hematology/Oncology inpatient service; supervision and bedside teaching of med students, pediatric and family medicine residents, med/peds residents, and in 2005, peds heme/onc fellows. Attending Morning Report when on service.

Three half day clinics/week, Pediatric Hematology/Oncology, and one half day Brain Tumor Clinic/week; supervision and bedside teaching of pediatric resident and 1 pediatric hematology/oncology fellow per session; additional teaching of undergraduate students, medical students, and physician assistant students on an ad hoc basis.

2002-2007 Pediatric Palliative Care Rounds, Cleveland Clinic Children’s Hospital. Bedside teaching of pediatric heme/onc and all other pediatric subspecialty fellows, and residents in pediatrics, family medicine, and med/peds for patients with palliative care consultation.

Joanne M. Hilden MD Curriculum Vitae 12

August 2011

2007-2011 Peyton Manning Children’s Hospital at St. Vincent, Indianapolis, INAttending physician 4 weeks on Pediatric Hematology/Oncology inpatient service; supervision and bedside teaching of 1st, 2nd, and 3rd year pediatric, family medicine, transition residents and 1 medical student, and often pharmacy students as well.

2002-2007 Pediatric Palliative Care Rounds, St. Vincent Children’s Hospital. Bedside teaching of residents in pediatrics, family medicine, OB, and med/peds for patients with palliative care consultation.

Administrative accomplishments in education:2005: Developed Pediatric Hematology/Oncology fellowship at Children’s Hospital Cleveland Clinic, with research side in collaboration with Cleveland Clinic Lerner Research Institute

Development of courses and seminars:

Regional:Augsburg College Symposium: “Reclaiming the Soul of Medicine.” Minneapolis, MN 2000. Member of organizing committee

Regional Conference organizer: “Palliative Medicine in the 21st Century: From Art to Science” Cleveland, OH 2004.

Organizer of Annual Peyton Manning Children’s Hospital Fall Pediatric CME Conference Indianapolis, IN 2008-10

Developer of Peyton Manning Children’s Hospital Medical Directors’ Leadership Skills Professional Development Series, quarterly,

2009 –11

Developer of Peyton Manning Children’s Hospital, monthly Medical Director’s Morning Report: A Series for Residentson

Professionalism 2009 – 11

National:Organizer of American Society of Clinical Oncology Annual Meeting

Education Session: “Pediatric Palliative & Hospice Care: Definitions and Implementation in Childhood Cancer Care,” New Orleans, LA, 2004

Organizer of ASPHO Presidential Symposium: Infant Leukemia: Epidemiology, Treatment, Biology. Toronto, Canada, 2007.

Trainees and mentees Listed in teaching portfolio

Joanne M. Hilden MD Curriculum Vitae 13

August 2011

Grant support 1. National Childhood Cancer Foundation PI: Peter Adamson, MD, Children’s Oncology Group (COG) chair. Role: Principal

Investigator, chair of infant ALL clinical trial AALL0631. Chairs Grant CA98543- 09 $7,500/yr, 2005 – through accrual of trial

2. Sisters of Charity, St. Vincent, Role Medical Director. Dates 2007-2010 Amount $399,800 for development of Child Protection

Service

3. Hope Street Kids Role: PI Amount $ 70,000 Dates 2003-05 Pilot: Parent Handbook for Palliative Care

4. Project of Death in America Faculty Scholars Program. Role: PI. Amount $150,000 Dates 2001-03 Children’s Oncology Group: Pediatric Advanced Illness Care Coordination

5. National Childhood Cancer Foundation Role: Chair of Pediatric Palliative Care Committee. Amount $ 16,649 Dates 2002-03 Children’s Oncology Group Chair’s Grant U10CA95861

6. Pine Tree Apple Tennis Classic Research Grants for St. Paul Children’s Hospital. Role: Director of Cancer Research.

1996: $ 69,0001997: $ 93,000

1998: $100,0001999: $260,000

2000: $290,000 2001: $267,000

7. Minnesota Medical Foundation Role: PI Amount $ 6,000 Dates 1994-96 Molecular Characterization of Pediatric Ewing’s Sarcoma &Primitive Neuroectodermal Tumor

8. Children’s Cancer Research Fund, University of Minnesota Role: PI Amount $ 20,000 Dates 1994-96 Characterization of 11q23 Acute Leukemia

9. American Society of Clinical Oncology Young Investigator Award. Role: PI Amount $ 26,500 Dates 1994-95 11q23 Acute Leukemia: Molecular & Clinical Studies

10. Children’s Cancer Research Fund, University of Minnesota. Role: PI Amount $ 17,200 Dates 1993-94 Molecular Biology of Infant Leukemia

Joanne M. Hilden MD Curriculum Vitae 14

August 2011

Bibliography Peer-reviewed publications

1. Warkentin PI, Hilden JM, Kersey JH, Ramsay NKC, McCullough JL: Transplantation of major ABO-incompatible bone marrow depleted of red cells by hydroxyethyl starch. Vox Sang 1984;48:89

2. Curtsinger JM, Hilden JM, Cairns JS, Bach FH: Evolutionary and genetic implications of sequence variation in two non-allelic HLA-DR cDNA sequences. Proc Natl Acad Sci USA 1987;84(1):209.

3. Hilden JM, Curtsinger JM, Cairns JS, Bach FH: DQ sequences in HLA-DR4 haplotypes. Hum Immunol 1987;18:261.

4. Chen CS, Hilden JM, Frestedt J, Domer PH, Moore R, Korsmeyer SJ, Kersey JH: The chromosome 4q21 gene (AF-4/FEL) is widely expressed in normal tissues and shows breakpoint diversity in t(4;11)(q21:q23) acute leukemia. Blood 1993;82:1080.

5. Hilden JM, Chen CS, Moore R, Frestedt J, Kersey JH: Heterogeneity in MLL/AF-4 fusion messenger RNA detected by the polymerase chain reaction in t(4;11) Acute Leukemia. Cancer Res 1993;53:3853.

6. Hilden JM, Kersey JH: The MLL (11q23) and AF-4 (4q21) genes disrupted in t(4;11) acute leukemia: molecular and clinical studies. Leuk Lymphoma 1994;14:189.

7. Hilden JM, Frestedt JL, Moore RO, Heerema NA, Arthur DC, Reaman GH, Kersey JH: Molecular analysis of infant ALL: MLL gene rearrangement and RT-PCR for t(4;11)(2q21;q23). Blood 1995;86:3876

8. Smith FO, Rauch C, Williams DE, March CJ, Arthur DA, Hilden JM, Woods WG, Dinndorf PA, Kersey J, Bernstein, ID: The human homologue of Rat NG2, a chondroitin sulfate proteoglycan is not expressed on the cell surface of normal hematopoietic cells, but is expressed by AML blasts from poor prognosis patients with abnormalities of chromosome band 11q23. Blood 1996;87:1123.

9. Gross TG, Hilden JM, MacMahon EME, Manivel JC, Ramsay NKC: Epstein-Barr virus associated non-Hodgkin lymphoma with relapse of Hodgkin disease. J Ped Hem/Onc 1996;18:182.

10. Frestedt JL, Hilden JM, Moore RO, Kersey JH: Differential expression of AF-4/FEL mRNA in human tissues. Genet Analysis: Biomed Eng 1996;12:147.

11. Frestedt JL, Hilden JM, Kersey JH: AF-4/FEL, a gene involved in infant leukemia: Sequence variation, gene structure, and possible homology with a genomic sequence on 5q31. DNA and Cell Biology 1996;15:669.

12. Hilden JM, Watterson J, Garr CL: Genetic testing for familial cancer: A clinician's perspective. Minnesota Medicine 1996;79:29.

13. Matloub YH, Smith C, Bostrom B, Koerper MA, O'Leary M, Khuder S, Smithson SA, Nickerson HJ, Silberman T, Hilden JM, Moertel CL, et al: One course versus two courses of antithymocyte globulin for the treatment of severe aplastic anemia in children. J Ped Hem/Onc 1997;19:110.

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14. Hilden JM, Smith FO, Frestedt JL, Moore RO, McGlennen R, Howells WB, Sorensen PHB, Arthur DC, Woods WG, Buckley J, Bernstein ID, and Kersey JH: MLL gene rearrangement, cytogenetic 11q23 abnormalities and expression of the NG2 molecule in infant acute myeloid leukemia. Blood 1997;89:3801.

15. Hilden JM, Brennom WS, Wolpert JJ, and Beckwith JB: Misleading leads: Wilms tumor with a metachronous lesion appearing in the remaining kidney. Medical and Pediatric Oncology 1998;30:180-182.

16. Hilden JM, Watterson J, Longee DC, Moertel CL, Dunn ME, Kurtzberg J, Scheithauer BW: Central nervous system atypical teratoid tumor/rhabdoid tumor: Response to intensive therapy and review of the literature. J Neuro-Onc; 1998;40:265-75

17. Heerema NA, Sather HN, Ge J, Arthur DC, Hilden JM, Trigg ME, and Reaman GH: Cytogenetic studies of infant acute lymphoblastic leukemia: poor prognosis of infants with t(4;11), a report of the Children's Cancer Group. Leukemia 1999;13:679-686.

18. Mantadakis E, Shannon KM, Singer DA, Finklestein J, Chan KM, Hilden JM, and Sandler ES. Transient monosomy 7: A case series in children and review of the literature. Cancer 1999;85;2655-61.

19. Jakacki RI, Cohen BH, Jamison C, Mathews VP, Arenson E, Longee DC, Hilden JM, Cornelius A, Needle M, Heilman D, Boaz JC, Luerssen TG: Phase II evaluation of interferon-alpha-2a for progressive or recurrent craniopharyngiomas. J Neurosurg 2000;92:255-260.

20. Hilden JM, Watterson J, Chrastek J: Tell the Children. JCO 2000;18:3193-95. Also published in “Classic Papers & Current Comments,” Supplement to JCO 2003;21(9):37s-39s

21. Hilden JM, Emanuel EJ, Fairclough DL, Link MP, Foley KM, Clarridge BC, Schnipper LE, Mayer RJ: Attitudes and practices among pediatric oncologists regarding end-of-life care: Results of the 1998 American Society of Clinical Oncology Survey. JCO 2001;19:205-212

22. Avramis VI, Sencer S, Periciou AP, Sather H, Bostrom BC, Cohen LJ, Ettinger AG, Ettinger LJ, Franklin J, Gaynon PS, Hilden JM, Lange B, Majlessipour F, Mathew P, Needle M, Neglia J, Reaman G, Holcenberg JS, Stork L. A randomized comparison of native escherichia coli asparaginase and polyethylene glycol conjugated asparaginase for treatment of children with newly diagnosed standard-risk acute lymphoblastic leukemia: A Children’s Cancer Group Study. Blood 2002;99(6);1986-1994.

23. Packer RJ, Biegel JA, Blaney S, Finlay J, Geyer JR, Heideman R, Hilden JM, Janss AJ, Kun L, Vezina G, Rorke LB, Smith M. Atypical teratoid/rhabdoid tumor of the central nervous system: Report on workshop. J Ped Hem/Onc 2002;24(5);337-342.

24. Hilden JM, Biegel JA, Finlay J, Janss AJ, Rorke LB, Scheithauer B, Meerbaum S, Walter A, Burger P. Central nervous system atypical teratoid/rhabdoid tumor: Results of therapy in children enrolled in a registry. J Clin Oncol ;22(14):2877-2884, 2004.

25. Spector LG, Xie Y, Robison LL, Heerema NA, Hilden JM, Lange B, Felix CA, Davies SM, Slavin J, Potter JD, Blair CK, Reaman GH, Ross JA. Maternal Diet and Infant Leukemia: The

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DNA Topoisomerase II Inhibitor Hypothesis. A report from the Children’s Oncology Group. Cancer Epidemiology, Biomarkers & Prevention, 14(3):651-655, 2005.

26. Mack JW, Hilden JM, Watterson SW, Grier HE, Weeks HC, Wolfe J: Parent and physician perspectives on quality of care at the end of life in children with cancer. J Clin Oncol 23: 9155-9161, 2005.

27. Johnston DL, Nagel K, O’Halloran C, Sencer SF, Kelly KM, Friebert S, Hilden JM, Friedman DL: Complementary & Alternative Medicine in Pediatric Oncology – Availability & Institutional Policies in Canada: A Report from the Children’s Oncology Group. Pediatr Blood Cancer. 2006 Dec;47(7):955-8.

28. Hilden JM, Dinndorf P, McGlennen R, Meerbaum S, Sather H, Heerema N: CCG 1953: Infant acute lymphoblastic leukemia: Analysis of Prognostic Factors. A report from the Children’s Oncology Group. Blood 2006; 108: 441

29. Spector, LC., Davies SM, Robison, LL, Hilden JM, Roesler M, Ross, JA. Birth characteristics, maternal reproductive history, and the risk of infant leukemia: A report from the Children’s Oncology Group. Cancer Epidemiology, Biomarkers, and Prevention 16(1): 128-34, 2007

30. Heald B, Hilden JM, Zbuk K, Norton A, Vyas P, Theil KS, Eng C. Severe TMD/AMKL with GATA1 mutation in a stillborn fetus with Down syndrome. Nat Clin Pract Oncol. 2007 Jul;4(7):433-8

31. Norton A, Fisher C, Liu H, Wen Q, Mundschau G, Fuster J, Hasle H, Zeller B, Webb KD, O’Marcaigh A, Sorrel A, Hilden J, Gamis A, Crispino JD, Vyas P. Analysis of JAK3, JAK2, and C-MPL mutations in transient myeloproliferative disorder and myeloid leukemia of Down Syndrome blasts in children with Down Syndrome. Blood 2007, Aug1, 110 (3), 1077

32. Mack JW, Joffe S, Hilden JM, Watterson J, Moore CL, Weeks JC, Wolfe J. Parents’ Views of Cancer-directed Therapy for Children with No Realistic Chance for Cure. J Clin Oncol 26:4759-4764, 2008

33. Dussel V, Kreicbergs U, Hilden JM, Watterson J, Moore C, Turner BG, Weeks JC, Wolfe J: Looking Beyond Where Children Die: Determinants and Effects of Planning a Child’s Location of Death. Journal of Pain and Symptom Management 37; 33-43, 2009

34. Salzer W, Dinndorf P, Dreyer Z, Hilden JM, Reaman G: Analysis of Infection Complications in Infants with Acute Lymphoblastic Leukemia Treated on the Children’s Cancer Group Protocol 1953: A Report from the Children’s Oncology Group. J Peds Hematol Oncol Jun;31(6):398-405, 2009

35. Ullrich C, Dussel V, Joffe S, Hilden JM, Watterson-Schaeffer J, Weeks JC, Wolfe J. Considerations about Hastening Death among Parents of Children Who Die of Cancer. Arch Pediatr Adolesc Med. Mar 2010 Mar;164(3):231-7

36. Ullrich C, Dussel V, Hilden JM, Sheaffer J, Lehmann L, and Wolfe J. End-of-life experience of children undergoing stem cell transplantation for malignancy: parent and provider perspectives and patterns of care. Blood. 2010; 115(19):3879-3885

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37. Johnson KJ, Roesler MA, Linabery AM, Hilden JM, Davies SM, and Ross JA. Infant Leukemia and Congenital Abnormalities: A Children’s Oncology Group Study. Pediatr Blood Cancer 2010; 55: 95-99.

38. Dussel V, Joffe S, Hilden JM, Watterson-Schaeffer J, Weeks JC, Wolfe J. Considerations about Hastening Death Among Parents of Children Who Die of Cancer. Arch Pediatr Adolesc Med 2010; 164: 231-237.

39. Ullrich CK, Dussel V, Hilden JM, Sheaffer JW, Moore CL, Berde CB, Wolfe J: Fatigue in Children with Cancer at the End of Life. J Pain Symptom Manage 2010; 40 (4) 483-494

40. Linabery AM, Puumala SE, Hilden JM, Davies SM, Heerema NA, Roesler MA, Ross JA. Maternal vitamin and iron supplementation and risk of infant leukemia: A report from the Children’s Oncology Group. Br J Cancer. 2010; 103(11):1724-8

41. Dussel V, Bona K, Heath JA, Hilden JM, Weeks JC, Wolfe J. Unmeasured costs of a child’s death: Perceived financial burden, work disruptions, and economic coping strategies used by American and Australian families who lost a child to cancer. J Clin Oncol, 29:1007-1013, 2011.

42. Dreyer Z, Dinndorf PA, Camitta B, Sather H, La M, Devidas M, Hilden JM, Heerema NA, Sanders J, McGlennen R, Carroll A, Behm F, Smith FO, Woods WB, Godder K, Reaman GH. Analysis of the Role of Hematpoietic Stem Cell Transplantation in Infants with Acute Lymphoblastic Remission and MLL Gene Rearrangements: A report from the Children’s Oncology Group. JClin Oncol 2011;29(2):214-22.

43. Fruge E, Lakoski JM, Luban N, Lipton JM, Poplack DG, Hagey A, Felgenhauer J, Hilden JM, Margolin JM, Vaiselbuh SR, Sakamoto KM. Increasing Diversity in Pediatric Hematology/Oncology. Pediatr Blood Cancer 2011;57:147-152

44. Gamis AS, Alonzo TA, Hilden JM, Sorrell AD, Berbing RB, Loew TW, Hathaway L, McGavran L, Barnard D. Taub J, Ravindrnath Y, Smith FO, Arceci R. Natural History Of Transient Myeloproliferative Disorder (TMD) Clinically Diagnosed In Down Syndrome Neonates: Outcomes From Children’s Oncology Group (COG) Study A2971. Blood, in press 2011. (Prepublished online August 17, 2011; doi:10.1182/blood-2011-04-350017)

45. Sam, TN, Kersey JH, Linabery AM, Johnson KJ, Heerema NA, Hilden JM, Davies SM, Reaman GH, Ross JA. MLL gene rearrangements in infant leukemia vary with age at diagnosis and selected demographic factors: A Children’s Oncology Group (COG) study. Pediatr Blood Cancer, in press 2011

46. Slater ME, Linabery AM, Spector LG, Johnson KJ, Hilden JM, Heerema NA, Robison LL, Ross, JA. Maternal exposure to household chemicals and risk of infant leukemia: A report from the Children’s Oncology Group. Cancer Causes and Control, in press 2011

Book

1. Hilden JM, Tobin DR, Lindsey K, Shelter from the Storm: Caring for a child with a life-threatening condition, Perseus Book Groups, Cambridge, first ed., 2003.

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Book Chapters and Reviews

1. Hilden JM, Frestedt JL, Kersey JH: Infant acute leukemia: molecular genetic and clinical studies. Leuk Lymphoma 1997;25:191

2. Schnipper L, Bitran JD, Blank LL, Blum D, Brock D, Bruera E, Emanuel EJ, Foley KM, Gordon DS, Hilden JM, Kagan RA, Levy MH, Lichter AS, Link MP, Penley WC, Smith TJ, Stanley K, Stovall E, Tokaz LK, Wood WC, and Mayer R. ASCO special article: Cancer care during the last phase of life. J of Clin Oncol 1998;16:1986-1996.

3. Hilden JM, Watterson J, Dehner LP: Uncommon Pediatric Tumors of the Thorax. In: Ragavan D, Brecher ML, Johnson DH, Meropol NJ, Moots PL, Thigpen JT (eds); Textbook of uncommon cancer, Second Edition. Chichester: John Wiley & Sons, 1999;565-580.

4. Hilden JM, Himelstein BP, Freyer DR, Friebert S, Kane JR: End-of-Life Care: Special issues in pediatric oncology. In: Foley KM, Geland H (eds); Improving palliative care for cancer. Institute of Medicine and National Research Council: National Academy Press, 2001;161-198

5. Gamis AS, Hilden JM: Transient myeloproliferative disorder, a disorder with too few data and many unanswered questions: Does it contain an important piece of the puzzle to understanding hemotopoiesis and acute myelogenous leukemia? J Ped Hem/Onc 2002;24(1),2-5.

6. Field MJ, Behrman RE, Hilden JM, et al.: When children die: Improving palliative and end-of-life care for children and their families. Institute of Medicine Committee on Palliative and End-of-Life Care for Children and Their Families: National Academy Press, 2002.

7. Wolfe J, Friebert S, Hilden J: Caring for children with advanced cancer – Integrating palliative care. Capital City Press, Ped Clin N Am 2002;49,1043-1062.

8. Hilden J: National Coalition for Cancer Survivorship’s Essential Care section of www.cancer a dvocacy.org , 2003.

9. Hilden JM, Friebert S, Himelstein BP, Freyer D, Wheeler J: Palliative care for the child with cancer, Chapter 15. In: Palliative care for infants, children, and adolescents: A practical handbook. Baltimore: Johns Hopkins University Press; 348-373, 2004.

10. Himelstein BP, Hilden JM, Morstad Boldt A, Weissman D: Medical Progress: Pediatric Palliative Care. New England Journal of Medicine; 350:1752-62, 2004.

11. Friebert S and Hilden J: Palliative care for children with cancer. In: Children’s Oncology Group Supportive Care of Children with Cancer. Altman AJ, ed.;379-396, 2004.

12. Friedman DL, Hilden JM, Powaski K. Issues and challenges in palliative care for children with cancer. Current Oncology Reports; 6:431-437, 2004

13. Walter AW, Hilden JM. Brain tumors in children. Current Oncology Reports; 6:438-444, 2004.

14. Hilden JM, Meerbaum SO: Pediatric Palliative and Hospice Care: Definitions and Implementation in Childhood Cancer Care. American Society of Clinical Oncology Education Book, pages 605-608, 2004.

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15. Lafond, D, Hilden JM. Pediatric Oncology Palliative Care Guidelines by joint efforts of the Association of Pediatric Oncology Nurses and the Children’s Oncology Group Palliative Care & Nursing Committees. COG/NCCF Public Website, 2005.

16. Hilden JM, Meerbaum S, Dehner LP: Uncommon Pediatric Tumors of the Thorax. In: Raghavan D, Brecher ML, Johnson DH, Meropol NJ, Moots PL, Rose PG (eds); Textbook of uncommon cancer, Third Edition. Chichester: John Wiley & Sons, 2006, 732-748

17. Hilden JM, Levien MG: Clinical Signs and Prognostic Factors in Common Pediatric Malignancies. In: Sabella C, Cunningham RJ; The Cleveland Clinic Intensive Review of Pediatrics, Second Edition. Philadelphia: Lippincott Williams & Wilkins, 2006, 473 – 484.

18. Hutton N, Jones B, Hilden JM. From Cure to Palliation: Managing the Transition. In: Child and Adolescent Psychiatric Clinics of North America, Pediatric Palliative Medicine. Vol 15, July 2006, 575.

19. Duncan J, Joselow M, Rauch P, Hilden JM. Program Intervention for Seriously Ill and Bereaved Children. In: Child and Adolescent Psychiatric Clinics of North America, Pediatric Palliative Medicine. Vol 15, July 2006, 739

20. Howard DS, Hilden JM: A Parent’s Perspective on Decision Making and Palliative Care in Pediatric Cancer. ASCO 2007 Educational Book: 186-187.

21. Kane JR, Hilden JM: Tools to Aid Decision Making in the Care of Pediatric Patients with Cancer. ASCO 2007 Educational Book: 188-192.

22. The ABCs of Infant Leukemia. Zweidler-McKay PA, Hilden JM. Curr Probl Pediatr Adolesc Health Care 2008 Mar;38(3):78-94.

23. Hurwitz CA, Lewandowski JG, Hilden JM: Palliative Care: Neonates, Children, and Adolescents. In: Palliative Medicine, Declan Walsh (ed), Elsevier, Chapter 194, 2009.

24. Levien ML, Gravette J, Hilden JM: Principles of Chemotherapy. In: Clinical Ophthalmic Oncology, Singh AD, Damato BE, Pe’er J, Murphree AL, and Perry JD, (eds), Elsevier, 2006, 50-53.

25. Nicholson CL, Hilden JM, Cohen BH. Childhood Brain Tumors. In: McInerny TK, Adam HM, Campbell D, Kamat DK, Kelleher KJ, eds. American Academy of Pediatrics Textbook of Pediatric Care 5th Elk Grove Village, IL: American Academy of Pediatrics; 2009; 1860.

Abstracts, competitive:

1. Hilden JM, Warkentin PI, Nelson C, McCullough J: A blood bank program for bone marrow processing and cryopreservation. Transfusion 21:15; 594, 1981. American Association of Blood Banks Annual Meeting, 1981 (Poster Presentation).

2. Hilden JM, Frestedt JL, Moore RO, Arthur DA, Heerema N, Reaman G Kersey JH: Molecular analysis of infant ALL: MLL gene rearrangement and RT-PCR for t(4;11). Experimental Hematology 22:796. International Society of Experimental Hematology Annual Meeting, 1994 (poster Presentation), 1994.

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3. Frestedt JL, Hilden JM, Moore RO, Kersey JH: Expression of the unique AF4 protein in normal tissues and infantile leukemia with a t(4;11)(q21;q23). International Society of Experimental Hematology 22:792, (poster Presentation), 1994.

4. Hilden JM, Smith F, Frestedt J, Moore R, McGlennen R, Howells B, Woods W, Kersey J: MLL gene rearrangement, cytogenetic 11q23 abnormalities, and expression of the 7.1 antigen in infant acute myeloid leukemia. Proc ASCO 14:156a, 1995. American Society of Clinical Oncology Annual Meeting, 1995 (poster Presentation).

5. Hilden JM, Moertel CL, Dunn ME, Scheithauer BW, Longee DC, Friedman HS: Treatment of CNS atypical teratoid/rhabdoid tumor in childhood. Presented (oral) at the 7th International Symposium of Pediatric Neuro-Oncology – Washington, D.C., 1996.

6. Hilden JM, Biegel J, Rorke L, Watterson J, Walter A: Registry for central nervous system (CNS) atypical teratoid tumor/rhabdoid tumor (ATT/RT): Treatment and outcome in 18 cases. Presented (poster) at the 9 th International Symposium on Pediatric Neuro-Oncology, 2000.

7. Loew TW, Gamis A, Smith FO, Massey GV, Woods WG, Hilden JM, Lange B, Alonzo TA, Chang M, Gerbing RB: Down syndrome patients with relapsed acute myelogenous leukemia. (poster, ASH) Blood 104(11):215b, 2004.

8. Hilden JM, Meerbaum S, Burger P, Finlay J, Janss A, Scheithauer BW, Walter AW, Rorke LB, Biegel JA: Registry for central nervous system (CNS) atypical teratoid tumor/rhabdoid tumor (AT/RT): Treatment & outcome in 42 cases. Presented (poster) at the 11 th International Symposium on Pediatric Neuro-Oncology – Boston, MA, 2004

9. Hilden JM, Dinndorf PA, Meerbaum SO, Sather H, Villaluna D, Heerema NA, McGlennen R, Smith FO, Woods WG, Dreyer Z, Reaman GH: CCG 1953: Acute Lymphoblastic Leukemia in Infants: Analysis of Prognostic Factors: A Report from the Children’s Oncology Group (Platform presentation). Blood 106(11):107a, 2005

10. Ulrich C, Weeks J, Hilden J, Watterson J, Moore C, Berde C, Wolfe J. Factors associated with fatigue in children with cancer at the end of life. Poster, American Society of Clinical Oncology, 2006.

11. Tekautz T, Cohen B, Farrar M, Hilden J: Atypical Teratoid Rhabdoid Tumor. In: Consensus and State-of-the-Art Workshop: Marrow Ablative Chemotherapy with Hematopoietic Stem Cell Rescue for Malignant Brain Tumors of Childhood and Adolescence. Podium, International Neuro-oncology meetings, Milan, 9/06.

12. Fanning SR, Jin T, Hilden JM, Advani A, Kalaycio M, Lichtin AE, Sekeres MA, Sobecks R, Moore HCF. Chemotherapy-Related Amenorrhea (CRA) among Premenopausal Patients Treated for Acute Leukemia. (poster) 2006 ASH Annual Meeting Abstracts, Part 1:108(11), Nov 16, 2006.

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13. Viny A, Hilden JM, Stallion A, Bleyer WA. The Racial Disparity Gap in Pediatric Leukemia and Lymphoma Survival Has Been Eliminated in Children But Not in Older Adolescents and Young Adults. 2006 ASH Annual Meeting Abstracts, Part 1:108(11), Nov 16, 2006 (Podium presentation).

14. Gamis AS, Alonzo TA, Hilden JM, Gerbing RB, Loew TW, Erdly L, McGavran L, Barnard D, Taub J, Ravindranath Y, Smith FO, Arceci R: Outcome of Down Syndrome (DS) children with acute myeloid leukemia (AML) or myelodysplasia (MDS) treated with a uniform prospective clinical trial – initial report of the COG trial A2971. 2006 ASH Annual Meeting Abstracts, Part 1:108(11), Nov 16, 2006. (poster)

15. Sharma M, Alonzo TA, Sorrell A, Gerbing RB, Hilden JM, Arceci R, Massey G, Doyle J, Bayer L, Perentesis JP, Ross J, Smith FO, Byrnes, R, Hussong J, Gamis A. Uniform Approach Better Defines Natural History of Transient Myeloproliferative Disorder (TMD) In Down Syndrome (DS) Neonates: Outcomes From Children’s Oncology Group (COG) Study A2971. 2006 ASH Annual Meeting Abstracts, Part 1:108(11), Nov 16, 2006 (poster)

16. Dreyer Z, Dinndorf P, Sather H, Carroll W, Hilden J, Shuster J, Dunn N, Oblendar M, Camitta B. Induction Intensification in Infant ALL Modifies Traditional Risk Factors: A Pediatric Oncology Group Study. Platform presentation – SIOP Sept 2006. Ped Blood and Cancer: Vol 47(4):381, Oct 1, 2006. Abstract #0.096.

17. Hilden JM. Partnership of Palliative Medicine Team and Hospitalists: Continuity of Care. Oral presentation, Specialty Hospitals Conference of National Association of Children’s Hospitals and Related Institutions (NACHRI), February 10-11, 2007 – Fort Lauderdale, FL

18. Dreyer Z, Dinndorf P, Sather H, Steuber P, Carroll W, Hilden J, Camitta B. Shortened, Intensified Therapy in Infant ALL: A Pediatric Oncology Group Study. Pediatric Blood & Cancer Vol 48 (6):605, June 1, 2007. Presented May 5, 2007 – Platform, Chosen "Best of ASPHO"

19. Dreyer Z, Dinndorf P, Sather H, La M, Hilden J, Winick N, Hunger S, Carroll W, Gaynon P, Camitta B. Unexpected Toxicity with Intensified Induction in Infant Acute Lymphoid Leukemia (ALL). JCO 25: 529s, June 20, 2007. Platform at ASCO 2007.

20. Dreyer Z, Dinndorf P, Sather H, Hilden J, Devidas M, Heerema N, Smith F, Carroll W, Reaman G, Camitta B. Hematopoietic Stem Cell Transplant (HSCT) vs. Intensive Chemotherapy in Infant Acute Lymphoblastic Leukemia (ALL). 2007 Platform at ASCO

21. Jakacki R, Zhou T, Holmes E, Packer R, Goldwein J, Mehta M, Hilden J, Pollack I. Outcome for Patients with Non-Pineal Supratentorial PNET Treated with Carboplatin as a Radiosensitizer During Radiotherapy (RT) Followed by Adjuvant Cyclophosphamide (CPM) and Vincristine (VCR): Preliminary Results of COG 99701. Platform, International Symposium of Pediatric Neuro-Oncology (ISPNO), January 2008.

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22. Robinson B, Devidas M, Carroll AJ, Heerema NA, Willman CL, Hudome A, Woods EC, Ballantyne N, Reaman GH, Hilden JM, Camitta BM, Winick N, Carroll WL, Hunger S, Dreyer Z, Felix CA. Specific MLL partner genes in infant Acute Lymphoblastic Leukemia (ALL) associated with outcome are linked to age and white blood cell count (WBC) at diagnosis: A Report on the Children’s Oncology Group (COG) P9407 Trial. Blood; 114(22):abstract 907, Poster 2009.

23. Ulrich CK, Dussel V, Hilden JM, Sheaffer JW, Moore CL, Berde CB, Weeks JC, Wolfe J. Understanding Fatigue in Children with Advanced Cancer. American Academy of Hospice and Palliative Medicine 2008 (AAHPM Abstract Award), oral presentation

24. Brown P, Hilden JM et al:  Report On Excessive Induction Toxicity in Infants with ALL Enrolled On COG Protocol AALL0631: A Children’s Oncology Group Study. Blood. 2009; 114(22). 3091a.

25. Ulrich CK, Dussel V, Hilden JM, Sheaffer JW, Lehman L, Wolfe J. End-of-life Experience of Children Undergoing Stem Cell Transplantation: Parent and provider expectations and patterns of care. Oral presentation, American Society of Hematology Annual Meeting, 2009 and American Association of Hospice and Palliative Medicine 2010

26. Urtishak KA, Wang L, Harvey R, Atlas SR, Chen, ML, Robinson BW, Moukarzel L, Cao K, Devidas M, Carroll AJ, Heerema NA, Hunger S, Reaman GH, Hilden JM, Camitta B, Winick N, Carroll WL, Zhang AY, Cory L, McVeigh S, Barrett JS, Dreyer ZE, Willman CL, Felix CA. Infant Acute Lymphoblastic Leukemias Are Pan-Sensitive to Obatoclax Across Molecular/Cytogenetic Subtypes, Especially MLL-ENL, and Gene Expression Profiles Determine Obatoclax IC50: A Report on the Children’s Oncology Group (COG) P9407 Trial. Poster at ASH 2010. Blood 2010; 116(21), 1137a

27. Kang H, Wilson CS, Harvey RC, Chen IM, Murphy MH, Atlas SR, Bedrick EJ, Devidas M, Carroll AJ, Robinson BW, Heerema NA, Hilden JM, Dreyer ZE, Camitta B, Winick N, Carroll WL, Felix CA, Reaman GH, Hunger SP, Willman, CL. Gene Expression Profiling Reveals Genes Predictive of Outcome in Infant Acute Lymphoblastic Leukemia (ALL) and Distinctive Age-Related Gene Expression Profiles (<90 Days vs. > 90 Days): A Children’s Oncology Group Study. Oral presentation at ASH 2010. Blood 2010; 116(21), 183a.

Submitted and under review for publication:

1. Ross JA, Linabery AM, Schoon C, Langer E, Spector LG, Hilden JM, Heerema NA, Radloff G, Tower RM, Davies SM. Ikaros variants modify susceptibility to leukemia in infants: A Children’s Oncology Group Report. Blood, submitted 2011

2. Salzer WL, Jones TL, Devidas M, Hilden JM, Winick N, Hunger SP, Carroll WL, Camitta B, Dreyer ZD. Modifications to Induction Therapy Decrease Risk of Early Death in Infants with Acute Lymphoblastic Leukemia Treated on Children’s Oncology Group P9407. Pediatri Blood Cancer, submitted 2011.

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3. Sorrell AD, Alonzo TA, Hilden JM, Gerbing RB, Loew TW, Hathaway L, McGavran L, Barnard D, Taub J, Ravindranath Y, Smith FO, Arceci R, WG, Gamis AS. Survival rates in children with Down syndrome and AML/myelodysplastic syndrome treated with reduced chemotherapy on the COG trial, COG A2971. Blood, submitted 2011

4. Bouffet E, Jakacki R, Goldman S, Hargrave D, Shroff M, Hukin J, Bartels U, Foreman N, Kellie S, Hilden J, Etzl M, Wilson B, Stephens D, Tabori U, Baruchel S; Phase II study of weekly vinblastine in recurrent/refractory pediatric low grade glioma. J Clin Oncol, Submitted 2011

5. Jakacki RI, Burger P, Zhou T, Holmes E, Kocak M, Onar A, Goldwein J, Mehta M, Packer R, Tarbell N, Fitz C, Vezina G, Hilden JM, Pollack I. Outcome for children with metastatic medulloblastoma treated with carboplatin during craniospinal radiotherapy and the inpact of anaplasia: Results of COG 99701. J Clin Oncol, Submitted 2011

6. Ross, JA, Linabery AM, Schoon C, Langer E, Spector LG, Hilden JM, Heerema NA, Radloff G, Tower RM, Davies SM. Ikaros variants modify susceptibility to leukemia in infants: A Children’s Oncology Group Report. Blood, submitted 2011

Media:

1. Pediatric Brain Tumor Foundation Internet Conference: “Combining Curative and Palliative Care for Children with Brain Tumors,” Internet live, and CD released 2003.

2. Script co-author for Sesame Street video: “Elmo and Child in Hospital: Here for You: Helping Children Cope With Serious Illness.” DVD released August 2006. The goal of this video is to assist parents, teachers, spiritual counselors, case managers, Child Life professionals, and other care-givers in teaching the communication with children about their complex illness.

Lay press articles:

1. If Cancer Gets the Upper Hand: Walking with Parents Through the Death of Their Child. Invited Editorial, Minneapolis Star Tribune, May 28, 1997. Page 11A

2. Finding Our Way, 2003 Knight Ridder Press Newspaper Series and on-line course: Finding Our Way: Living with Dying in America" is a 15-part newspaper series distributed by Knight Ridder/Tribune. “Written by national leaders in the medical, sociological, religious and cultural fields, the series explores the complex issues that face seriously ill Americans, their caregivers, families and communities.’ Author of “When a Child Is Dying: Smallest Patient Offers Biggest Lesson” http://webpages.scu.edu/ftp/fow/pages/course/c-12.html

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