Japan Environment and Children’s Study (JECS)

I4C Barcelona, Spain 2011

Update: Progress to date

Cohort summary Years of recruitment: January, 2011 – December, 2013 (3 years)

Number of live births at baseline: 100,000 children

Follow up status: Follow-up programs will be implemented until the

participant children reach at the age of 13.

Biospecimen InventoryBiospecimens

Environmental samples

Acknowledgements

The recruitment of pregnant women was started in January, 2011.

Pregnant women should be T1, 12 ~16 weeks of gestation.

Japan Environment and Children’s Study International Symposium

was held in Tokyo on February 4, 2011.

An open working group meeting on birth cohort studies is scheduled to

be held at the International Society for Environmental Epidemiology

(ISEE) conference in Barcelona, Spain on September 17, 2011.

Eisaku TODA , Kei MORI Ministry of the Environment, JapanHiroshi SATOH National Institute for Environmental Studies, Japan

SAMPLECOLLECTED

( YES/NO)

TIMING OF SAMPLE COLLECTION(weeks gestation / months of age)

LOCATION OF SAMPLE COLLECTION(e.g. child’s bedroom)

CONDITIONS OF STORAGE MONTHS SINCE STORED

TOTAL NUMBER OF SAMPLES

COLLECTED

NUMBER OF SAMPLES

AVAILABLE SEPT 2011

Prenatal First year of life

Indoor air sample TBD

Dwelling dust collection TBD

Soil sample TBD

Drinking water TBD

Hair sample from pets TBD

Others: TBD

Geographic Information Systems (GIS):

Utilize participants’ home addresses obtained from questionnaire.

Others: 1. Daily monitoring data of ambient air quality 2. Results of measurement of surface water quality

Population sample

Update: Primary outcomes

Planning to use a national cancer registration. 　

SAMPLE

TIMING

( Indicate YES (Y) or NO (N) AND

weeks gestation/months of age)

CONDITIONS OF STORAGE MONTHS SINCE

STORED

BRIEF DESCRIPTION OF

COLLECTION METHOD

TOTAL NUMBER OF

SAMPLES COLLECTED

NUMBER OF SAMPLES

AVAILABLE

SEPT 2011

Prenatal (Mother)

At birth (Mother/Child)

First year of life (Child)

Blood Y / T1*, T2* Y /Mother N (Collected at 6 years old)

Stored at -80℃. For long-term storage, stored at -150℃.

T1*: collect 32 ml. T2*: collect 33 ml. At birth: collect 18 ml. 100,000 (plan)

Serum Y/ T1, T2 Y/Mother N Stored at -80℃. For long-term storage, stored at -150℃.

T1: collect 32 ml. T2: collect 33 ml. At birth: collect 18 ml. 100,000 (plan)

Urine Y/ T1, T2 N N (Collected at 6 years old)

Stored at -80℃. For long-term storage, stored at -150℃.

T1: collect 35 ml. T2: collect 25 ml. 100,000 (plan)

Saliva N N N

Buccal swab N N N

Vaginal swab N N N

Cord blood N Y/Child N Insert a needle into an umbilical vein and collect cord blood 35 ml. 100,000 (plan)

Blood spots N Y/Child N DNA is stored at normal temperature. TSH is stored at -80℃.

Collect a few drops of blood from a baby in a few days after birth. 100,000 (plan)

Placenta N N N

Meconium N N N

Hair sample N Y/Mother & Child N Stored at normal temperature. Take 3 cm from the root of hairs. 100,000 (plan)

Nail sample N N N

Breast milk N Y/Mother N Stored at -80℃. Collect breast milk in one month after delivery. 100,000 (plan)

Milk teeth N N N

Others N N N

Explanatory note: T1* means 12~16 weeks of gestation. T2* means 22~28 weeks of gestation.