james levine, m.d., ph.d., : the new science of sedentariness

8/12/2019 James Levine, M.D., Ph.D., : The New Science of Sedentariness

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GET UP!WHY YOUR CHAIR IS KILLING YOU AND WHAT

YOU CAN DO ABOUT IT

JAMES A LEVINE

MAYO CLINIC + ARIZONA STATE UNIVERSITY


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HOW CAN SOMETHING

THAT WE DO SO MANY

TIMES EACH DAY HURT

US?


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QUIZ:

1 POINT FOR EACH YES

Do you work seated on a chair?Have you ever shopped on the Internet?Do you watch TV sitting for one hour a day or more?Do you ever eat while watching TV or in the car?Have you ever Internet dated?

Do you own a recliner?If you go to a party, do you seek out a chair?Look at your sofa. Does it have an imprint of your buttocks?Do you spend more time with friends electronically than in real life?Have you ever fantasized about or engaged in sexual intercourse

while in a chair?


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QUIZ:

1 POINT FOR EACH YES

Do you work seated on a chair?Have you ever shopped on the Internet?Do you watch TV sitting for one hour a day or more?Do you ever eat while watching TV or in the car?Have you ever Internet dated?

Do you own a recliner?If you go to a party, do you seek out a chair?Look at your sofa. Does it have an imprint of your buttocks?Do you spend more time with friends electronically than in real life?Have you ever fantasized about or engaged in sexual intercourse

while in a chair?

HOW DID YOU DO?

12: Chair pre-addict35: Chair addict68: Chair imprisoned

910: Chairaholic


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THE CHAIRMANS RISE TO POWER

200 years


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FEED ME: MOVE ME

Lavoisier, Antoine (1743-1794)
http://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=3&cad=rja&uact=8&ved=0CDgQFjAC&url=http://scienceworld.wolfram.com/biography/Lavoisier.html&ei=RmyWU8jfKsKmyATx24LACg&usg=AFQjCNFKPzsHeQwLu7cyIaMM23x8XUvMYQ&sig2=pY2EF0JMfD10r0OMpcKFhA&bvm=bv.68445247,d.aWwhttp://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=3&cad=rja&uact=8&ved=0CDgQFjAC&url=http://scienceworld.wolfram.com/biography/Lavoisier.html&ei=RmyWU8jfKsKmyATx24LACg&usg=AFQjCNFKPzsHeQwLu7cyIaMM23x8XUvMYQ&sig2=pY2EF0JMfD10r0OMpcKFhA&bvm=bv.68445247,d.aWwhttp://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=3&cad=rja&uact=8&ved=0CDgQFjAC&url=http://scienceworld.wolfram.com/biography/Lavoisier.html&ei=RmyWU8jfKsKmyATx24LACg&usg=AFQjCNFKPzsHeQwLu7cyIaMM23x8XUvMYQ&sig2=pY2EF0JMfD10r0OMpcKFhA&bvm=bv.68445247,d.aWwhttp://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=3&cad=rja&uact=8&ved=0CDgQFjAC&url=http://scienceworld.wolfram.com/biography/Lavoisier.html&ei=RmyWU8jfKsKmyATx24LACg&usg=AFQjCNFKPzsHeQwLu7cyIaMM23x8XUvMYQ&sig2=pY2EF0JMfD10r0OMpcKFhA&bvm=bv.68445247,d.aWwhttp://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=3&cad=rja&uact=8&ved=0CDgQFjAC&url=http://scienceworld.wolfram.com/biography/Lavoisier.html&ei=RmyWU8jfKsKmyATx24LACg&usg=AFQjCNFKPzsHeQwLu7cyIaMM23x8XUvMYQ&sig2=pY2EF0JMfD10r0OMpcKFhA&bvm=bv.68445247,d.aWwhttp://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=3&cad=rja&uact=8&ved=0CDgQFjAC&url=http://scienceworld.wolfram.com/biography/Lavoisier.html&ei=RmyWU8jfKsKmyATx24LACg&usg=AFQjCNFKPzsHeQwLu7cyIaMM23x8XUvMYQ&sig2=pY2EF0JMfD10r0OMpcKFhA&bvm=bv.68445247,d.aWwhttp://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=3&cad=rja&uact=8&ved=0CDgQFjAC&url=http://scienceworld.wolfram.com/biography/Lavoisier.html&ei=RmyWU8jfKsKmyATx24LACg&usg=AFQjCNFKPzsHeQwLu7cyIaMM23x8XUvMYQ&sig2=pY2EF0JMfD10r0OMpcKFhA&bvm=bv.68445247,d.aWw


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NEAT: NON-EXERCISE ACTIVITY

THERMOGENESIS


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NEAT: NON-EXERCISE ACTIVITY

THERMOGENESIS


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NEAT: NON-EXERCISE ACTIVITYTHERMOGENESIS

SitMore:More

fat


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Body

postures

Movements

e.g. walking


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300

400

500

600

Lie Sit Standambulate

Tmemind

Lean Obese

**

*

Science307;584

SitMore:More

fat


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THE BRAIN

STRAIN


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THE BRAIN

STRAIN


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Orexin increases

NEAT more in:

lean rats

than obese

ObeseLean

Orexin A (nmol)Kiwaki AJP2004, Novak AJP2006

NEAT

THE BRAINSTRAIN


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AM I AN

INDIVIDUAL?

Transportation

Ecology

Schooling

Economy

Urban environment


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WestF

orest

EastFo

rest

Savana

Gulf of Guinea

150 km

Study regions in Ivory Coast (Cote dIvoire)

3352women & men


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Forrester et al 2010 Urban StudRural

Urban

Urban

AM I ANINDIVIDUAL?

AM I AN INDIVIDUAL?


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United States 3,319 counties Diabetes

AM I AN INDIVIDUAL?


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Frances Mabel Staples

OCTOBER 2013 | VOLUME 15 | NUMBER 10


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When were you born?

I was born on June 30, 1928 at asummer campsite in the woods. Ihad two sisters, Elsie and barb

My family did logging there andpicked rutabagas when it was

rutabaga season. They picked thoseby the bushel.


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What was life like when you were

little?

It was beautiful. We had to work all thetime, help our parents outside in theheat and sun.

We used to wash socks on one of those

washboards. That was tough duty,those socks. They sure get dirty.


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What foods do you remember?Same as what we eat now. Oatmeal.Bacon. Fry bread. Pancakes.

We had a big garden. We used to goup and take radishes. And wed go out

in the woods. We had deer meat, ourdads hunted and fished. We pickedberries.


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TRADITIONAL -400 KCAL/DAY

MODERN


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TRADITIONAL -600 KCAL/DAY

MODERN


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FEED ME: MOVE ME


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Occupation-type NEAT(kcal/day)

Chair-bound 300

Seated work: no option of moving 700

Seated work: discretion & requirement to move 1000

Standing work; e.g. homemaker, shop assistant 1400

Strenuous work; e.g. agriculture 2300

Black, Eur J Clin Nutr50:72

Data assuming BMR = 1600 kcal/day


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Sitting

Standing

GumChewing

StairClimbing 1 mph 2 mph 3 mph

Walking

200

70

220

150

155

20

Kcal/hour

AM I AN


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Call meAuntie.

AM I ANINDIVIDUAL?

AM I AN


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Call meAuntie.

AM I ANINDIVIDUAL?

WHEN I CAN BE


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THE CHAIRMANS

CURSE

THE CHAIRMANS


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THE CHAIRMANS

CURSE


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THE CHAIRMANS

CURSE

TRADITIONAL


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TRADITIONAL

MODERN

? KCAL/DAY

THECHAIRMANS

CURSE


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CHAIR

CURSED

CAR

CHAIR


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CHAIR

CURSED

CAR


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San Francisco in 2013, the average persons travel time

by foot was 4 minutes/day. In a leg-based travel active scenario, average commutes

would increase by 18 minutes. 2,404 avoided premature deaths per year. healthcare cost savings in San Francisco would

approximate $34 billion/year.


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OUST THE

CHAIRMAN


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J Phys Act Health. 2009;6:781

Non-Exercise Activity Thermogenesis


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N=7,433

Walk

n play:4 months 7,543 users6 months 28,000 users

The app:

Non-Exercise Activity Thermogenesis


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NASA Design of the future2005


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Dress NEAT:


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Clinical Space Tradit ionalModern


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Depression

Stressmanagement

Mens health

Womens healthOb, menopause

Diabetes

CardiovascularCHF, HTN

Cognitivedecline

Diabetes

Clinical Space

Homelesschildren

Poverty clustersHomelesschildren

Tradit ionalModern

Responsib le

2006


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2006

ACTIVE CLASSROOM


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ACTIVE CLASSROOM

ACTIVE CLASSROOM


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ACTIVE CLASSROOM

2012


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Copeland

Science proceeds from the assumption that misery isnot fated..


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..that because all events are caused, allproblems can eventually be solved.

Science proceeds from the assumption that misery isnot fated..

james levine, m.d., ph.d., : the new science of sedentariness

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