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Jake Kushner

I. GENERAL BIOGRAPHICAL INFORMATION

A. Personal

1. Name: Jake Alden Kushner, M.D.

2. Date of birth; citizenship: June 19, 1965; U.S.A.

B. Education

a. Undergraduate education:

University of California at Berkeley, 1983-1987, B.A. (Biochemistry), 1987

b. Medical education:

Albany Medical College, 1990-1994 M.D., 1994

c. Postgraduate training and fellowship appointments:

Resident in Pediatrics, Brown University, Rhode Island Hospital, 1994-1997

Clinical Fellow in Pediatric Endocrinology, Harvard Medical School, Children's Hospital, Boston, 1997-2000

Research Fellow, Harvard Medical School, Joslin Diabetes Center, Mark Montiminy M.D. Ph.D., 1998-1999

Research Fellow, Harvard Medical School, Joslin Diabetes Center and Howard Hughes Medical Institute, Morris White Ph.D., 1999-2003

C. Employment:

1. Current employment:

Medical Director, McNair Interests

McNair Scholar, McNair Medical Institute

2. Previous faculty positions:

Instructor in Medicine, Department of Pediatrics, Harvard Medical School, 2000-2003

Assistant in Medicine, Children's Hospital, Boston, 2000-2003

Research Associate, Molecular and Cellular Physiology Division, Joslin Diabetes Center, 2002-2003

Assistant Professor of Pediatrics, University of Pennsylvania School of Medicine, 2004-2011

Staff Physician, Children's Hospital of Philadelphia, 2004-2011

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Staff Physician, Children's Hospital of Philadelphia, 2004-2011Associate Professor of Pediatrics (with tenure), Baylor College of Medicine, 2011-2018

Chief, Section of Pediatric Diabetes and Endocrinology, Baylor College of Medicine, 2011-2017

McNair Medical Institute Scholar, Baylor College of Medicine, 2011-2018

Chief of Service, Diabetes and Endocrinology, Texas Children’s Hospital, 2011-2017

Co-Director, Diabetes Research Center, Baylor College of Medicine, 2011-2018

Associate Professor of Molecular and Cellular Biology, Baylor College of Medicine, 2012-2018

Faculty, Graduate Program in Molecular and Cellular Biology, Baylor College of Medicine, 2012-2018

Faculty, Graduate Program in Immunology, Baylor College of Medicine, 2013-2017

3. Previous courtesy faculty appointments at other institutions: Attending Physician, Ben Taub

Hospital, Houston, Texas, 2011-2017

D. Other advanced training/experience:

Training in the Use of the “Stanford Educational Framework Curriculum”, University of Pennsylvania School of Medicine, 2010

Advanced Quality Improvement Course (AQI), Texas Children's Hospital, 2012

Academic Medical Department Leadership (AMDL) Course, University of Texas Health Sciences Center Houston School of Public Health, 2016

E. Other information

1. Honors or awards:

Lawson Wilkins Pediatric Endocrinology Society, Eli Lilly Fellowship, 1999-2000

Juvenile Diabetes Research Foundation International Postdoctoral Research Fellowship, 2001-2003

Lawson Wilkins Pediatric Endocrinology Society Clinical Scholar Award, 2003-2005

Charles H. Hood Foundation Child Health Research Grant, 2003-2005

NIH Mentored Clinical Scientist Career Development Award, 2003-2008

National Institutes of Health (NIH) Pediatric Research Loan Repayment Program, 2003

National Institutes of Health (NIH) Pediatric Research Loan Repayment Program, 2005 (competitive renewal)

Basil O'Connor Career Development Award, 2005-2007

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National Institutes of Health (NIH) Pediatric Research Loan Repayment Program (competitive renewal), 2007

American Society of Clinical Investigation, 2009

McNair Medical Institute Scholar, Baylor College of Medicine, 2011-present

Who’s Who in America, 2011-present

Castle Connolly Top Doctor, 2012-present

Best Doctors, 2012-present

Award of Excellence for Presentation at Baylor Pediatric Grand Rounds, Baylor College of Medicine, 2012. This award is given by the Department of Pediatrics for the most outstanding Baylor Pediatric Grand Rounds during the academic year of July 1, 2011 through June 30, 2012. Awarded for “Experimental Avenues to Treat Type 1 Diabetes: A Pediatrician's Perspective”

delivered on September 30, 2011.

Houstonia Magazine, Top Doctors, 2013

Spirit of nPOD Award, 2015. The Network for Pancreatic Organ Donors with Diabetes is a tissue bank project funded by the JDRF. The award is for being a champion of the nPOD project.

Research Mentorship Award, Department of Pediatrics, Baylor College of Medicine, 2015.

Fulbright & Jaworski L. L. P. Faculty Excellence Award, Teaching and Evaluation category, Baylor College of Medicine, 2016

Member, Academy of Distinguished Educators, Baylor College of Medicine, 2017

2. Board certification:

American Board of Pediatrics, 1997

American Board of Pediatrics, Pediatric Endocrinology, 2001 (re-certified 2008).

American Board of Pediatrics, Pediatric Endocrinology, maintenance of certification December

2015 (valid until 12/17/2020).

National Board of Physicians and Surgeons, Pediatrics and Pediatric Endocrinology, 2015.

3. Other non-academic positions:

Pediatric House Officer, Landmark Medical Center, Woonsocket, RI, 1995-2003

II. RESEARCH INFORMATION

A. Research support

Past:

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“Pdx1: a Modifying Gene of Insulin Receptor Substrate (IRS)-2 Regulation of Islet Cell Mass”; Eli Lilly Fellowship; Lawson Wilkins Pediatric Endocrinology Society; J.A. Kushner, Principal Investigator; 1999-2000; overall direct cost, $35,000 (grant)

“IRS-2 and PDX-1 dependent regulation of endocrine pancreas development and function”; Juvenile Diabetes Research Foundation International; J.A. Kushner, Principal Investigator; 2001-2003; overall direct cost, $95,676 (grant)

“PTEN regulation of glucose homeostasis and islet proliferation”; Career Development in Diabetes for Pediatric Endocrinologists, NIH-NIDDK, 1K12DK063696-01; J.A. Majzoub, Principal Investigator; J.A. Kushner, Recipient; 2002-2003; overall direct cost, $115,750 (grant).

“Cell cycle regulation of islet growth”; Charles H. Hood Foundation Child Health Research Grant; J.A. Kushner, Principal Investigator; 2003-2005; overall direct cost, $136,364 (grant).

“Cyclin D2 regulation of islet growth”, Mentored Clinical Scientist Career Development Award, NIH NIDDK, 7 K08 DK064101-02, J.A. Kushner, Principal Investigator; 2003-2008; overall direct cost, $625,050 (grant).

“PTEN regulation of glucose homeostasis and islet growth”; Lawson Wilkins Pediatric Endocrinology Society Clinical Scholar Award; J.A. Kushner, Principal Investigator; 2003-2005; overall direct cost, $50,000 (grant).

“Cell cycle regulation of islet growth”; March of Dimes, Basil O'Connor Career Development Award; J.A. Kushner, Principal Investigator; 2005-2007; overall direct cost, $136,364 (grant).

“Beta cell regeneration in aged mice”; Juvenile Diabetes Research Foundation; J.A. Kushner, Principal Investigator; 2006-2009; overall direct cost, $500,000 (grant).

BMPs: Powerful mitogenic signals that govern beta cell proliferation, Juvenile Diabetes Research Foundation; 2007-2010; J.A. Kushner, Principal Investigator; annual direct cost, ;

overall direct cost, $459,090 (grant).

“BMPs - a novel drug target to regenerate beta cells in diabetes”; Children's Hospital of Philadelphia, Foerderer - Murray New Investigator Grant; J.A. Kushner, Principal Investigator; 2007-2008; overall direct cost, $50,000 (grant).

“Mitogenic signals that govern beta cell proliferation”; NIH-NIDDK, 3P30DK019525; University of Pennsylvania Diabetes Endocrine Research Center, Core Pilot and Feasibility Grant Application; J.A. Kushner, Principal Investigator; 2007-2008; overall direct cost, $40,000 (grant).

“p130 Regulation of Islet Growth”; NIH-NIDDK, 1R03DK078546; J.A. Kushner, Principal

Investigator; 2007-2009; overall direct cost, $100,000 (grant).

“Progenitors of beta cell mass expansion in arrested autoimmune diabetes”; Juvenile Diabetes Research Foundation; J.A. Kushner, Principal Investigator; 2008-2010; overall direct cost, $454,546 (grant).

“The role of the pancreas in beta cell regeneration”; Juvenile Diabetes Research Foundation; K.C. Herold, Principal Investigator; J.A. Kushner, Co-Investigator; 2008-2010; overall direct cost, $49,908 (grant).

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“A surprising pro-proliferative role for ARF in beta cells”; Juvenile Diabetes Research Foundation; A. Granger, Principal Investigator; J.A. Kushner, Fellowship Mentor; 2009-2011; overall direct cost, $98,720 (to Dr Granger) (grant).

“Epigenomics of the regenerating and aging beta-cell” NIH-NIDDK: Beta Cell Biology Consortium (U01), RFA-DK-09-011; K.H. Kaestner, Principal Investigator; J.A. Kushner, Co-Investigator; 2010-2012; annual direct cost for sub-aim, $80,000; overall direct cost for sub-aim, $160,000 (grant). The PI on this application was changed to Changhong Li as of July 1, 2011 in order to allow the work to continue at the Children's Hospital of Philadelphia. Dr. Kushner directed the science on this award as Co-PI but did not draw salary thereafter.

“A study to examine the effectiveness and lineage mechanism of long term oral sitaglipin in β-cell mass expansion in aged mice”; Merck Investigator-initiated Studies Program (unrestricted corporate funded pre-clinical research); J.A. Kushner, Principal Investigator; 2010-2012; annual direct cost, $52,083; overall direct cost, $104,166 (grant). The PI on this application was changed to Changhong Li as of July 1, 2011 in order to allow the work to continue at the Children's Hospital of Philadelphia. Dr. Kushner directed the science on this award as Co-PI but

did not draw salary thereafter.

“The lineage mechanism of gastrin-induced β-cell mass expansion”; Pfizer; J.A. Kushner, Principal Investigator; 2011; overall direct cost, $151,262 (grant). The PI on this application was changed to Changhong Li as of July 1, 2011 in order to allow the work to continue at the Children's Hospital of Philadelphia. Dr. Kushner directed the science on this award as Co-PI but did not draw salary thereafter.

“Penn Center of Excellence for Regenerative Medicine”; State of Pennsylvania; J.A. Epstein, Principal Investigator; J.A. Kushner, Co-Investigator; 2008-2012; overall direct cost for sub-aim, $200,000 (grant). The PI on this application was changed to Changhong Li as of July 1, 2011 in order to allow the work to continue at the Children's Hospital of Philadelphia. Dr. Kushner directed the science on this award as Co-PI but did not draw salary thereafter.

“Islet cell regeneration in vivo”; Johnson and Johnson; J.A. Kushner, Principal Investigator; 2011-2012; annual direct cost, $95,476; overall direct cost, $190,952 (sponsored research). The PI on this application was changed to Changhong Li as of July 1, 2011 in order to allow the work to continue at the Children's Hospital of Philadelphia. Dr. Kushner directed the science on this award as Co-PI but did not draw salary thereafter.

“Fine Mapping and Functional Evaluation of Selected Type 1 Diabetes Loci”; NIH-NIDDK, DP3 DK-08-5708; H. Hakonarson, Principal Investigator; J.A. Kushner, Co-Investigator; 2009-2014; annual direct cost for sub-aim, ~$40,000; overall direct cost for sub-aim, approximately $200,000 (grant).

Bone Morphogenic Proteins as Novel Regulators of Beta Cell Growth”, NIH-NIDDK, 1R01DK081469; J.A. Kushner, Principal Investigator; 2008-2014; annual direct cost, $200,000; overall direct cost, $1,000,000 (grant).

“Diabetes Endocrinology Research Center”; NIH-NIDDK, Mouse Metabolism and Islet Core, 5P30 DK-07-9638; L. Chan, Principal Investigator; J.A. Kushner, Co-Investigator; 2007-2014; Dr. Kushner directs a sub-core and serves as the newly appointed co-director of the center; annual direct cost for sub-aim, ~$30,000; overall direct cost for sub-aim, approximately $30,000.

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“Assessment of Beta Cell Stress and Death by Epigenetic Changes of Insulin”; Juvenile Diabetes Research Foundation; K.C. Herold, Principal Investigator; J.A. Kushner, Co-Investigator; 2012-2014; annual direct cost for Kushner sub-Aim year 1 $73,363; overall direct

cost of Kushner sub-Aim, $177,075 (grant). (NCE)

“Cell Lineage and Homeostasis of Pancreatic Beta Cells in the Aged”, NIH-NIA, 1R01AG040110; J.A. Kushner, Principal Investigator; 2011-2016; annual direct cost, $225,000; overall direct cost, $1,769,625. (NCE until 2017)

“Mentoring Behavioral Scientists for Career Development in Pediatric T1D Research”, NIH-NIDDK, 1K12DK097696-01, B.J. Anderson, Principal Investigator; 2012-2017.

“Texas Children's Hospital and Baylor College Of Medicine Trialnet Clinical Center”, NIH-NIDDK, 1U01DK103180-01, M.J. Redondo, Principal Investigator; 2014-2017; annual direct

cost, $310,660.

“Quality and Research Strategic Advisor”, T1D Exchange. 2016-2018; annual direct cost, $18,512. I play a role to advise and represent the T1D Exchange emerging quality improvement initiative as an advocate and champion. This position is designed to support the program office’s ability to design, develop, and launch a successful learning care and research program to support the needs of patients, clinicians, and researchers over the next 10 years.

B. National scientific participation

1. Journal editorial boards, etc:

Editorial board membership:

Associate Editor, Islets, 2013-Present

Stem Cell Reviews, 2007-2010

Journal reviewer:

Proceedings of the National Academy of Sciences, 2001-Present

Experimental Cell Research, 2004-Present

Diabetes, 2004-Present

Molecular and Cellular Biology, 2004-Present

Journal of Clinical Investigation, 2004-Present

Diabetologia, 2004-Present

American Journal of Physiology – Endocrinology and Metabolism, 2005-Present

Journal of Endocrinology, 2005-Present

Nature Clinical Practice Endocrinology & Metabolism, 2006-Present

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Endocrine Reviews, 2006-Present

PLoS Medicine, 2006-Present

Development, 2007-Present

Regulatory Peptides, 2007-Present

Journal of Molecular Medicine, 2007-Present

Gastroenterology, 2008-Present

Journal of Investigative Medicine, 2008-Present

Nature, 2008-Present

Science, 2008-Present

Nature Reviews Endocrinology, 2008-Present

Molecular Therapy, 2008-Present

Cell Metabolism, 2008-Present

Cell Stem Cell, 2008-Present

Journal of Endocrinology, 2008-Present

Molecular Endocrinology, 2009-Present

Endocrinology, 2009-Present

Developmental Biology, 2009-Present

Developmental Cell, 2009-Present

PLoS One, 2009-Present

Mechanisms of Ageing and Development, 2010-Present

Journal of Diabetes Investigation, 2010-Present

Journal of Gerontology: Biological Sciences, 2011-Present

Islets: 2013-Present

Nature Medicine: 2014-Present

Journal of Pediatrics, 2015-Present

2. Review panels:

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International:

Member, Islet Biology and Transplantation Study Section Juvenile Diabetes Research Foundation, Medical Science Review Committee, 2004

Reviewer, Project Grant Application, Diabetes UK, 2005

Reviewer, RD Lawrence Fellowship Grants Committee, Diabetes UK, 2005

Reviewer, D-Cure (Diabetes Care in Israel) and the Juvenile Diabetes Research Foundation, 2005

Reviewer, Israel Science Foundation 2005


Reviewer, Joint Program on Prevention and on Beta Cell Biology and Cell Therapy, D-Cure (Diabetes Care in Israel) and the Juvenile Diabetes Research Foundation, 2006


Reviewer, Equipment Grant Application, Diabetes UK, 2007

Reviewer, Medical Science Review Committee, Academic R&D Proposal, Juvenile Diabetes Research Foundation, 2007

Reviewer, Academic R&D Proposal, Medical Science Review Committee, Juvenile Diabetes Research Foundation, 2006

Reviewer, Regeneration, Inflammation and the Immune Response, Medical Science Review Committee, Juvenile Diabetes Research Foundation, 2008



Reviewer, Fondation pour la Recherche Médicale (A major private foundation supporting academic biomedical research in France), 2009

Reviewer, Academic R&D Proposal, Medical Science Review Committee, Juvenile Diabetes Research Foundation, 2010


Reviewer, European Research Council, 2010

Reviewer, Swiss National Science Foundation, 2010

Co-Chair, “Functional Beta Cell Mass”, Medical Science Review Committee, Juvenile Diabetes Research Foundation, 2011

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Reviewer, "Integrated Research on Genomics and Pathophysiology of the Metabolic Syndrome and the Diseases arising from it" (META2011), Agence Nationale de la Recherche, France.

Reviewer, " Pathways and Targets for Beta Cell Regeneration”, Medical Science Review

Committee, Juvenile Diabetes Research Foundation, 2011

Reviewer, Fonds Wetenschappelijk Onderzoek (Foundation for Scientific Research, Belgium), 2011

Reviewer, Israel Science Foundation, ISF JDRF Joint Program in Type 1 Diabetes Research,

2012.

Reviewer, Center Grants, Juvenile Diabetes Research Foundation, 2013

Reviewer, Israel Science Foundation, ISF JDRF Joint Program in Type 1 Diabetes Research, 2013.

Reviewer, Leona M. and Harry B. Helmsley Charitable Trust Type 1 Diabetes Breakthrough Therapeutics Initiative, 2013-2014.

Member, Scientific Advisory Committee, Type 1 Diabetes (T1D) Research Consortium The Leona M. and Harry B. Helmsley Charitable Trust, 2013-2014.

Member, Scientific Review Committee, Diabetes Research Connection, 2014-Present

Reviewer, Israel Science Foundation, ISF JDRF Joint Program in Type 1 Diabetes Research, 2014.

Reviewer, Fonds Wetenschappelijk Onderzoek (Foundation for Scientific Research, Belgium),

2015

Member, Scientific Advisory Committee, The Type 1 Diabetes (T1D) Program of the Helmsley Charitable Trust, Helmsley Breakthrough Initiative. This panel reviewed exploratory projects of rare patients and clinical outliers to better understand the causes and development of T1D as

well as identify new therapeutic strategies. 2015.

Reviewer, British – Israel Research and Academic Partnership (BIRAX) Regenerative Medicine Initiative, The British Council, 2016.


National:

Member, Research Grant Review Committee, American Diabetes Association, 2007-2011

Member, Application review board, Visiting Professorship Program in Endocrine Pancreas Preservation, The Endocrine Society, 2010

Reviewer, Pediatric Endocrine Society, 2011

External Advisor, UCSF Endocrinology NIH NIDDK K12, August 2012, San Francisco, CA.

https://urldefense.proofpoint.com/v2/url?u=https-3A__www.britishcouncil.org.il_en_birax2015&d=DQMGaQ&c=ZQs-KZ8oxEw0p81sqgiaRA&r=62mnqM5zXEUwCE61hOtBrg&m=3-p4nHGhk3iknxlHB1uKWC2wMKaceh5YV49VQfO8hNg&s=QfYeL8NPP2utDrn0-7zMswnsbeIw_ZYnsJ2l2HhmgSs&e=

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Reviewer, Core Pilot and Feasibility Grants, Yale University NIH NIDDK Diabetes Research Center, 2012

Reviewer, Core Pilot and Feasibility Grants, Baylor College of Medicine NIH NIDDK Diabetes

Research Center, 2012

Reviewer, Postdoctoral Fellowships, Juvenile Diabetes Research Foundation, 2012

Reviewer, Core Pilot and Feasibility Grants, University of Pennsylvania NIH NIDDK Diabetes Research Center, 2012

Reviewer, Core Pilot and Feasibility Grants, Johns Hopkins NIH NIDDK Diabetes Research Center, 2012


Member, Expert Reviewer Committee, 2015 Innovation Fund (IF) competition, Canada

Foundation for Innovation

Member, Unitio T1D Exchange Advisory Committee, Boston MA, November 2014 - Present.


Member, T1D Exchange Task Force, 2015-2016.


Reviewer, Core Pilot and Feasibility Grants, Boston Area University NIH NIDDK Diabetes Research Center, 2015

Reviewer, Core Pilot and Feasibility Grants, University of Michigan NIH NIDDK Diabetes


Federal Review (Special Emphasis Panels or Ad Hoc):

Member, Special Emphasis Panel/Scientific Review Group 2008/10 ZDK1 GRB-B (O1) X meeting, National Institutes of Health, 2007

Member, Special Emphasis Panel/Scientific Review Group 2009/10 ZRG1 EMNR-C (58) R, National Institutes of Health, 2009

Ad-Hoc member, NIH-NIDDK, Diabetes, Endocrinology, and Metabolic Diseases B Sub-Committee (DDK-B), National Institutes of Health. 2010

Member, Special Emphasis Panel/Scientific Review Group 2010/10 ZDK1 GRB-N (O3), National Institutes of Health, 2010

Reviewer, CADO Cellular Aspects of Diabetes and Obesity Study Section, National Institutes of Health. 2012

Ad-Hoc member, NIH-NIDDK, Diabetes, Endocrinology, and Metabolic Diseases B Sub-Committee (DDK-B), National Institutes of Health. 2013.

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Federal Review (Standing Member of an NIH Study Section):

Member, NIH-NIDDK, Diabetes, Endocrinology, and Metabolic Diseases B Sub-Committee (DDK-B), National Institutes of Health. 2013-2016

Chair, NIH-NIDDK, Diabetes, Endocrinology, and Metabolic Diseases B Sub-Committee (DDK-B), National Institutes of Health. 2016-2018

Industry:

External Advisory Council, Beta Cell Biology, Merck, Rahway N.J, December 2008.

External Research Advisory Council, Johnson and Johnson Cardiovascular Spring House, PA, 2011.

T1D Steering Committee, Lexicon Pharmaceuticals, December 2014 - Present.

Consultant, Virta Health, San Francisco CA, May 2017.

Consultant, Know Foods, August 2017.

Advisory Committee, Sotagliflozin T1 EMDAC, Sanofi, Bridgewater NJ, July & August, 2018.

Consultant, Sanofi Sotagliflozin Customer Voice Advisory Board Meeting, San Diego CA, June 2018.

Consultant, Sotagliflozin Core Council Advisory Board Meeting, San Diego CA, November, 2018.

Local:

Reviewer, Core Pilot and Feasibility Grants, University of Pennsylvania Diabetes Endocrine Research Center, 2010

Reviewer, Texas Children’s Hospital Global Health Center Stimulus Award Program, 2011

Reviewer, Core Pilot and Feasibility Grants, Baylor College of Medicine NIH NIDDK Diabetes Research Center, 2012

Reviewer, Chao Scholars Award Program, Baylor College of Medicine, 2012.

Reviewer, Texas Children’s Hospital Pediatric Pilot Research Award Program, 2012.

Reviewer, Pediatric Pilot Research Awards, Baylor College of Medicine, 2012



Reviewer, Pediatric Pilot Research Awards, Baylor College of Medicine, 2013.

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Research Reviewer, Baylor College of Medicine Pediatric Research & Fellows’ Symposium, 2013


Reviewer, Pediatric Pilot Research Awards, Baylor College of Medicine, 2014.


Reviewer, Core Pilot and Feasibility Grants, Baylor College of Medicine NIH NIDDK Diabetes



Research Reviewer, Baylor College of Medicine Pediatric Research & Fellows’ Symposium, 2015

Reviewer, Pediatric Pilot Research Awards, Baylor College of Medicine, 2015

National Abstracts:

Reviewer, Abstracts of the Annual Meeting, Pediatric Academic Societies, 2006

Reviewer, Abstracts of the Annual Meeting, Pediatric Academic Societies, 2007

Reviewer, Abstracts of the Annual Scientific Session, American Diabetes Association, 2007



Local Abstracts:

Abstract Reviewer, Congenital Hyperinsulinism and Related Disorder of Insulin Secretion Symposium, Department of Pediatrics, University of Pennsylvania, 2006

Abstract Reviewer/Poster Moderator/Judge 2012 Department of Pediatrics Fellow’s Research Symposium



3. Professional society memberships and elected positions:

Professional Society Memberships:

Member, Pediatric Endocrine Society, 2000-Present

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Member, American Diabetes Association, 2004-Present

Member, Endocrine Society, 2009-Present

Member, American Association for the Advancement of Science, 2012-Present

Member, American College of Healthcare Executives, 2015-Present

Honorary Society Memberships:

Member, Society for Pediatric Research, 2006-Present

Member, American Society of Clinical Investigation, 2009-Present

Fellow, American Academy of Pediatrics, 2014-Present.

Member, American Pediatric Society, 2016-Present

Elected Positions in Professional Societies:

President, Society for Pediatric Research, 2014-2015 (Vice President 2012, President Elect

2013, Past President 2015).

Committee Service in Professional Societies:

Co-Chair, Mentoring Committee, Society for Pediatric Research, 2012-2015

Co-Director, Young Investigator Mentoring Program, Society for Pediatric Research, 2012-2015

Community Service Board Memberships:

Member, American Diabetes Association Houston, Community Board, 2011-2014

Member, National Board of Directors, College Diabetes Network, 2012-2015

4. Invited lectures, presentations, and research seminars:

Visiting professorships:

1. “Beta Cell Regeneration”. Merck Visiting Professor, Endocrine Grand Rounds, Indiana University School of Medicine, Indianapolis, IN. April, 2010.

2. “Beta Cell Regeneration”. Merck Visiting Professor Endocrine Grand Rounds, Temple

University School of Medicine, Philadelphia PA. May, 2010.

3. “Beta Cell Regeneration”. Merck Visiting Professor, Metabolism Forum, Stedman Nutrition and Metabolism Center, Duke University School of Medicine, Durham, NC. September, 2010.

4. “Beta Cell Regeneration”. Merck Visiting Professor. Endocrinology Research Seminar,

University of Chicago Department of Medicine, Chicago, Ill. February, 2011.

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5. “Beta Cell Regeneration”. Merck Visiting Professor. Endocrine Grand Rounds, Robert Wood Johnson School of Medicine, New Brunswick, NJ. March, 2011.

6. “Beta Cell Regeneration”. Kroc Visiting Professor. Endocrine Grand Rounds, Stanford

University, Stanford, CA. September, 2011.

7. "Experimental avenues to treat type 1 diabetes: a pediatrician's perspective”, Dr. James Marks Lecture, Pediatric Grand Rounds, University of Texas at Southwestern, Dallas, TX. March 2012.

8. “Health promotion for people with type 1 diabetes: care versus cure”, 2nd Annual Dr. Marv and Beth Rallison Lectureship in Endocrinology & Diabetes, Pediatric Grand Rounds, University of Utah, Salt Lake City, UT. April 2016.

9. “Interrogating the regenerative capacity of human beta cells in patients with type 1 diabetes”, Taubman Institute Visiting Professor Lecture, Department of Pediatrics and Communicable Diseases, University of Michigan School of Medicine, Ann Arbor, MI. October 2016.

International lectures:

1. “Beta Cell Replication”. European Association for the Study of Diabetes and Juvenile Diabetes Research Foundation 10th Oxford Workshop on Diabetes Research, Oxford UK, August, 2005.

2. “Adult Beta-Cells Exhibit Equal Proliferation Potential”. Programming Pancreatic Beta Cells, a FEBS-EMBO workshop, El Perello, Spain, October, 2006.

3. “Beta Cell Regeneration”, Dept of Cellular & Physiological Sciences Seminar Series, University of Brittish Columbia, Vancouver, BC, Canada, February, 2008.

4. “Growth and Regeneration of Adult Beta Cells of the Islets of Langerhans Does Not Involve Specialized Progenitors”. Canadian Diabetes Association Annual Meeting,

Montreal, Canada, October, 2008.

5. “Beta Cell Regeneration”. Journal of Internal Medicine and Royal Swedish Academy of Sciences, Regenerative Medicine - From Stem Cells to the Clinic, Nobel Forum, Karolinska Institute, Stockholm Sweden, March, 2009.

6. “Adult beta cell turnover”. EMBO workshop: "Disease, Development, and Stem Cells of the Pancreas", Stockholm, Sweden, June, 2010.

7. "The kinetics of beta-cell turnover and regeneration". 15th EASD Oxford Hagedorn Workshop, Keble College, Oxford University, Oxford, UK, August, 2010.

8. “Beta Cell Regeneration”. Seminar Series, Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Canada. November, 2010.

9. “Experimental Avenues To Treat Type 1 Diabetes: A Pediatrician's Perspective On The Past, Present, And Future”. “Cystic Fibrosis Related Diabetes (CFRD): Pathophysiology

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and Treatment”. Reunión Pediátrica de las Américas, Mexico City, Mexico. February 2012.

10. “Measurement of turnover and cell division in vivo in relation to beta cell regeneration”, 4th International Congress on Stem Cells and Tissue Formation, Dresden, German. July 2012.

11. “Interrogating the regenerative capacity of pancreatic islets: birth and death”, Keynote speaker. University of Alberta and University of Brittish Columbia Islet Club, Fernie,

Canada. February 2014.

12. “The role of aging in β-cell and alpha cell regeneration”. 2014 Pediatric Academic Societies Meeting, Vancouver, Canada, May, 2014.

13. “Patient-centered care for improved outcomes in type 1 diabetes”, XVII Interamerican

Pediatrics Congress, Mexico City, Mexico, January 2015.

14. “Type 1 diabetes models” The Iceland Summit on Type 1 Diabetes, sponsored by the Helmsley Charitable Trust Iceland. 15 world experts representing beta cell biologists, immunologists, clinical researchers, and clinicians are convening to provide an integrated set of five-year priorities that will hopefully increase the understanding of the cause/causes of type 1 diabetes, October 2015.

15. “A novel, highly proliferative population of islet endocrine cells in adolescent and adult human pancreata”. 2nd Joint Meeting of the EASD Islet Study Group and Beta Cell Workshop, Dresden, Germany, May, 2017

National lectures:

1. “PDX-1: a Modifying Gene of Insulin Receptor Substrate (IRS)-2 Regulation of Islet Cell Mass”. Lawson Wilkins Pediatric Endocrine Society Meeting, Pediatric Academic

Societies Meeting, Boston, MA. May, 2000.

2. “PDX-1: a Modifying Gene of Insulin Receptor Substrate (IRS)-2 Regulation of Islet Cell Mass”. Endocrine Research Conference, Children’s Hospital Boston, Harvard Medical School, Boston, MA, September, 2000.

3. “The IRS-2 Signaling System Regulates Beta-Cell Function Through PDX-1”. Metabolism Interest Group seminar series, University of Utah School of Medicine, Salt Lake City, UT, April, 2002.

4. “The IRS-2 Signaling System Regulates Beta-Cell Function Through PDX-1”. Pediatric

Research Conference, Oregon Health Sciences University, Portland, OR, July, 2002.

5. “PDX-1 and PTP-1B: Modifying Genes of IRS-2.” Diabetes Endocrine Research Conference, University of Pennsylvania School of Medicine, Philadelphia, PA, September, 2002.

6. “PDX-1 and PTP-1B: Modifying Genes of IRS-2”. Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Diabetes Research Conference, Denver, CO October, 2002.

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7. “PDX-1 and PTP-1B: Modifying Genes of IRS-2”. Washington University, Metabolism Conference, St. Louis, MO, December, 2002.

8. “Cell cycle regulation of islet growth”. Endocrine Division Conference, Children's Hospital

of Philadelphia, Philadelphia, PA, January, 2003.

9. “Ptp1b Disruption Delays Onset of Diabetes in Irs2 Knockout Mice”. Keystone Symposium: Toward Understanding Islet Biology, Keystone, Colorado, January, 2003.

10. “Pdx1 restores beta cell function in Irs2 knockout mice”. Diabetes Center and Department of Pediatrics, University of California at San Francisco, San Francisco, CA, April 2003.

11. “Common Threads in Types I and II Diabetes”. 2003 Pediatric Academic Societies Meeting, Seattle, WA, May, 2003.

12. “β-cell Biology”. Diabetes Center and Department of Pediatrics, University of California at San Francisco, San Francisco, CA, August 2003.

13. “Cell Cycle Regulation of Islet Growth”. Harvard Medical School, Brigham and Women's Hospital/Children's Hospital Boston Combined Endocrine Grand Rounds, Boston, MA,

February, 2004.

14. “Cell Cycle Regulation of Islet Growth”. NIH Center for Molecular Studies in Digestive and Liver Disease Research Seminar, Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, May, 2004.

15. “PTEN Regulation of Glucose Homeostasis and Islet Growth”. Scientific Sessions, American Diabetes Association, Orlando FL, June, 2004.

16. “Cell Cycle Regulation Of Islet Growth”. Mid-Atlantic Diabetes Research Symposium, Clinical Center, NIH, Bethesda, MD, September, 2004.

17. “Cell Cycle Regulation of Islet Growth”. University of Pittsburgh, Endocrinology Grand Rounds, Pittsburgh PA. December, 2004.

18. “Cell Cycle Regulation Of Islet Growth”. Kimmel Cancer Center, Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA. March,

2005.

19. “Cell Cycle Regulation of Islet Growth.” Diabetes Seminar, Diabetes and Endocrinology Research Center, Columbia University Medical Center, New York, NY, November, 2005.

20. “Regulation of Adult Beta Cell Growth and Function”. National Institutes of Health/NIDDK,

Laboratory of Genetics & Physiology, Bethesda MD, November, 2005.

21. “Beta Cell Turnover in Mice”. Keystone Symposium: Pancreatic Islets: From Development to Transplantation, Taos, NM, February, 2006.

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22. “Beta-cell Turnover in Mice: Cellular Fate and Progenitors”. Lawson Wilkins Pediatric Endocrine Society Meeting, Pediatric Academic Societies Meeting, San Francisco, CA, April 2006.

23. “Beta Cell Regeneration Capacity Acutely Declines with Advanced Age”. American Diabetes Association Annual Scientific Sessions, Washington D.C., June, 2006.

24. Beta-Cell Turnover: Cellular Progenitors and Molecular Regulation of Proliferation”. NIH Inter-Institute Endocrine Grand Rounds, National Institutes of Health, Bethesda, MD,

October, 2006.

25. “Adaptive Beta Cell Proliferation Is Greatly Limited With Advanced Age”. Eastern Society for Pediatric Research, Philadelphia, PA, March, 2007

26. “Beta-Cell Turnover: Cellular Progenitors and Molecular Regulation of Proliferation”. Endocrine Grand Rounds, University of Pittsburgh School of Medicine, Pittsburgh, PA, April, 2007.

27. “Beta Cell Replication Dynamics”. Mathematical Biosciences Institute Workshop: Insulin Secretion, Insulin Action, and Type 2 Diabetes, Ohio State University, Columbus, OH,

May, 2007.

28. “D-Type Cyclins Are Actively Regulated By Protein Stability In Beta Cells, Which Powerfully Restricts Beta Cell Mass Expansion”. American Diabetes Association Annual Scientific Sessions, Chicago Il, June, 2007.

29. Where do beta cells regenerate from?”. Islet Cell Resource Center (ICR) Consortium 3rd Annual Islet Workshop, University of Illinois at Chicago, Chicago, Il, October, 2007.

30. “Growth and regeneration of adult beta cells: Does it involve specialized progenitors?”. City of Hope 8th Annual Levine Symposium, Newport Beach, CA, January, 2008.

31. “Beta-Cell Turnover: Cellular Progenitors and Molecular Regulation of Proliferation”. Pacific Northwest Research Institute, Seattle, WA, January, 2008.

32. “Growth and Regeneration of Adult Beta Cells of the Islets of Langerhans Does Not Involve Specialized Progenitors.” Metabolism Interest Group seminar series, University

of Utah School of Medicine, Salt Lake City, UT, March, 2008.

33. “Beta-cell Regeneration is Severely Restricted With Advanced Age”. Keystone Symposia: Islet and Beta Cell Development and Transplantation, Snowbird, UT, April, 2008.

34. “β-Cell Progenitors in Adult Pancreas”. 2008 Pediatric Academic Societies and Asian Society for Pediatric Research Joint Meeting, Honolulu, HI, May, 2008.

35. “Beta Cell Regeneration”. Pediatric Grand Rounds, Sanford School of Medicine, The University of South Dakota, Sioux Falls, SD, August, 2008.

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36. “Growth and Regeneration of Adult Beta Cells of the Islets of Langerhans Does Not Involve Specialized Progenitors”. DRTC Seminar Series, Vanderbilt University, Nashville, TN, September, 2008.

37. “Is augmented β-cell proliferation a realistic pharmacological goal in man?”. Beta Cell Scientific Input Session, Merck and Company, Rahway, NJ, November 2008.

38. “Beta Cell Regeneration”. Research Seminar, Diabetes Group, Department of Pathology, University of Florida, Gainesville, FL, March, 2009.

39. “Regeneration of the Pancreatic Beta Cells of the Islets of Langerhans. A pediatrician's perspective”. Pediatric Grand Rounds, University of Missouri Children's Hospital, Columbia, MO, June, 2009.

40. “Beta Cell Regeneration”. Endocrinology Research Seminar, Baylor College of Medicine,

Houston, TX. October, 2009.

41. “Molecular Determinants of Beta Cell Survival and Mass Expansion”. Endocrinology Research Seminar, Baylor College of Medicine, Houston, TX. October, 2009.

42. “Beta Cell Regeneration and Life Cycle”. Endocrine Grand Rounds, Yale University

School of Medicine, New Haven, CT, November, 2009.

43. “Beta Cell Regeneration”. Endocrinology Grand Rounds, Eastern Virginia Medical School, Norfolk, VA, November, 2009.

44. “Studies to Determine the Lineage Mechanism of Beta Cell Persistence in Type 1 Diabetes”. 3rd Annual nPOD Organizational and Scientific Update, Pentagon City, VA, November, 2009

45. “D-cyclins in the control of pancreatic beta cell replication”. 10th Annual Rachmiel Levine Diabetes and Obesity Symposium, Las Vegas, NV, March, 2010.

46. “Beta Cell Regeneration”. Johnson and Johnson, Spring House, PA, July, 2010.

47. “Beta Cell Regeneration”. Department Seminar Series, Department of Molecular & Comparative Pathobiology. John Hopkins University School of Medicine, Baltimore, MD, October, 2010.

48. “Beta Cell Regeneration”. Endocrinology Grand Rounds, Department of Pediatrics, Columbia University School of Medicine, New York, NY, October, 2010.

49. “Beta Cell Regeneration”. Research Seminar, Division of Endocrinology, Metabolism & Lipid Research, Department of Medicine, Washington University School of Medicine, St

Louis, MO, October, 2010.

50. “Beta cell regeneration: challenges and opportunities”. Pfizer, Groton, CT, November, 2010.

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51. “β-cell Regeneration: Tools assays quantitative methods to assess the feasibility of programs in therapeutic areas”. Beta Cell Research Council, Cardiovascular Metabolic Therapeutic Area, Johnson and Johnson, Spring House, PA, December, 2010.

52. “Beta Cell Regeneration”. Endocrine Grand Rounds, University of Michigan School of Medicine, Ann Arbor MI, January, 2011.

53. “Beta Cell Regeneration. Strategies To Identify Therapeutic Targets That Beta Cell Mass And Durably Increase Human Beta Cell Function”. GTC Bio Diabetes Summit,

Philadelphia PA, March, 2011.

54. “Beta Cell Regeneration” Northwestern Comprehensive Center on Obesity and Endocrinology Seminar Series, Feinberg School of Medicine, Northwestern University, Chicago Ill. March, 2011.

55. “Beta Cell Regeneration: Challenges And Opportunities”. Endocrinology Section Seminar, Department of Pediatrics, Baylor College of Medicine, Houston, TX. March, 2011.

56. “Beta Cell Regeneration”. Research Seminar, Diabetes Research Center, The Methodist

Hospital Research Institute, Houston, TX. March, 2011.

57. “Beta Cell Regeneration: Challenges And Opportunities”. Hillblom Scholar Series, Larry L. Hillblom Islet Research Center, Division of Endocrinology, Diabetes & Hypertension, UCLA David Geffen School of Medicine, Los Angeles, CA. February 2012.

58. "Beta Cell Regeneration: Challenges And Opportunities”, Touchstone Diabetes Center, University of Texas at Southwestern, Dallas, TX. March 2012.

59. “Beta Cell Regeneration: The Search for Improved Type 1 Diabetes Therapies”, Diabetes Center Conference, Albert Einstein College of Medicine, Bronx, New York.

April 2012.

60. “Pediatric Hypothyroidism: Disease Presentation and Management Throughout the Age Spectrum”, Baylor College of Medicine 64th Annual Pediatric Postgraduate Symposium, Houston, TX. April 2012.

61. “Beta Cell Regenerative Capacity during Aging”, Symposium: Beta Cell Proliferation in Mice and Humans, American Diabetes Association Scientific Sessions, Philadelphia, PA. June 2012.

62. “Pediatric Hypothyroidism: Disease Presentation and Management Throughout the Age Spectrum”, Baylor College of Medicine Primary Care Pediatric Conference 2012, Lost Pines, TX. July 2012.

63. “Pediatric Diabetes: Management for the Primary Care Pediatrician”, Baylor College of Medicine Primary Care Pediatric Conference 2012, Lost Pines, TX. July 2012.

64. “Interrogating the Regenerative Capacity of Pancreatic Beta Cells”, Pediatric Research Seminar, University of Texas Health Sciences Center, Houston, TX. October 2012.

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65. "Experimental avenues to treat type 1 diabetes: a pediatrician's perspective”, Pediatric Grand Rounds, University of Texas at Houston Health Sciences Center, Houston, TX. February 2013.

66. “Beta cell replication”, JDRF nPOD Annual Meeting, Atlantic Beach, Florida, February 2013.

67. "What can we learn from the ‘outliers’ and physiologic states”, JDRF, Sanford Health, and Helmsley Charitable Trust Workshop: “Human Type 1 Diabetes: Addressing

Knowledge Gaps”, Sanford Health, Sioux Falls S.D., April 2013.

68. "Beta cell regeneration for type 1 diabetes: challenges and opportunities”, Lexicon Pharaceuticals, The Woodlands, TX., June 2013.

69. "Beta Cell Regeneration for Type 1 and Type 2 Diabetes: Challenges and opportunities”, Annual meeting, Texas chapter of the American Association of Clinical Endocrinologists, Austin, T.X., August 2013.

70. “Diabetes Research: Interrogating the Regenerative Capacity of Pancreatic Islets”, Research Seminar, Diabetes Research Center, The Methodist Hospital Research

Institute, Houston, TX. September, 2013.

71. "Diabetes Research: Interrogating the Regenerative Capacity of Pancreatic Islets”, Molecular Medicine Research Seminar, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA. October, 2013.

72. “Recognizing and Appropriately Managing Type 2 Diabetes in Children and Adolescents”, Baylor College of Medicine 66th Annual Pediatric Postgraduate Symposium, Houston, TX. March 2014.

73. "Interrogating the Regenerative Capacity of Pancreatic Islets”, Annual Diabetes

Symposium of Wisconsin, Medical College of Wisconsin, Milwaukie, WI, May, 2014.

74. “Supporting the Young Adult with Diabetes”, American College Health Association Annual Meeting, San Antonio, Texas, presented with Danielle Petrunich (Bentley College); Christina Roth (CEO, College Diabetes Network). May, 2014.

75. “Beta cell regeneration for patients with diabetes: challenges and opportunities”, Johnson and Johnson, Spring House, PA, August, 2014

76. “Health promotion for people with type 1 diabetes: care versus cure”, Rice Medical Humanities Symposium, Rice University, November, 2014.

77. “Health promotion for people with type 1 diabetes: care versus cure”, STEM disciplines and careers in science, technology, engineering and mathematics, Congressional Youth Advisory Council, Congressman Pete Olson, Member of the United States of Americanb House of Representative for Texas's 22nd congressional district, Alvin, TX, December

2014

78. “Health promotion for people with type 1 diabetes: care versus cure”, Pediatric Grand Rounds, Texas Tech University of Health Sciences Center, Lubbock, TX, January 2015

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79. “Interrogating the regenerative capacity of human beta cells in patients with type 1 diabetes”, nPOD 7th Annual Meeting, St. Pete Beach, Florida, February 2015.

80. “The changing climate for pediatric research: challenges and opportunities”, Pediatric Academic Societies Meeting, Society for Pediatric Research Presidential Address, San Diego, California, May 6, 2015.

81. “Interrogating the regenerative capacity of human beta cells in patients with type 1 diabetes”, Pediatric Endocrinology Society for Texas Oklahoma, Louisiana, and

Arkansas (PESTOLA) 2016 Conference, Fort Worth, TX, January 23-24, 2016

82. “Vision Zero: Reducing Preventable Harm for People with Type 1 Diabetes”, T1D Exchange QI Initiative Kickoff, Tampa, FL, March 2016.

83. “Medical nutrition therapy for people with type 1 diabetes: fact versus fiction” Physicians Culinary Medicine Conference sponsored by the Goldsbury Foundation and The Children’s Hospital of San Antonio, San Antonio, TX, May 2016.

84. “Health promotion for people with type 1 diabetes: care versus cure”, Pediatric Grand Rounds, Nationwide Children’s Hospital, Ohio State University School of Medicine

Humanities Symposium, April 2017.

85. “Medical nutrition therapy for people with type 1 diabetes: fact versus fiction”, Low Carb Breckenridge 2018, Breckenridge, CO, March 2018

Local lectures:

1. “PDX-1: a Modifying Gene of Insulin Receptor Substrate (IRS)-2 Regulation of Islet Cell Mass”. Endocrine Research Conference, Children’s Hospital Boston, Harvard Medical School, Boston, MA, September, 2000.

2. “Emerging Technologies in Diabetes”. New England Chapter of the Juvenile Diabetes

Research Foundation, Framingham, MA, November, 2000.

3. “The IRS-2 Signaling System Regulates Beta-Cell Function Through PDX-1”. Joslin Research Seminar, Harvard Medical School, Boston, MA, February, 2002.

4. “The IRS-2 Signaling System Regulates Beta-Cell Function Through PDX-1”. Endocrine Research Conference, Children’s Hospital Boston, Harvard Medical School, Boston, MA, April, 2002.

5. “Cell cycle regulation of islet growth”. Joslin Research Seminar, Harvard Medical School, Boston, MA, September, 2003.

6. “Cell Cycle Regulation of Islet Growth”. Neonatology Research Seminar, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, April, 2004

7. “Cell Cycle Regulation of Islet Growth”. NIH Center for Molecular Studies in Digestive and Liver Disease Research Seminar, Division of Gastroenterology, Department of Medicine,

University of Pennsylvania School of Medicine, Philadelphia, PA, May, 2004.

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8. “Cell Cycle Regulation Of Islet Growth”. Cell Biology & Physiology Program, Cell and Molecular Biology Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, PA, September, 2004.

9. “Islet Growth In An Experimental Model Of Diabetes”. Eastern Pennsylvania Chapter of the Juvenile Diabetes Research Foundation, Philadelphia, September, 2004.

10. “Cell Cycle Regulation of Islet Growth.” Institute for Diabetes, Obesity, and Metabolism, and the Division of Endocrinology, Diabetes, and Metabolism Seminar Series, University of

Pennsylvania School of Medicine, Philadelphia, PA, September, 2005.

11. “Diabetes Therapy.” Diabetes Center Seminar, Children's Hospital of Philadelphia, Philadelphia, PA. January, 2006.

12. “Introduction to Basic Research; Dr. Strangelove, Or How I Stopped Worrying and Learned To Love The Bomb” Responsible Conduct of Research, The Joseph Stokes, Jr. Research Institute Annual Scientific Symposium, Children's Hospital of Philadelphia, Philadelphia, PA, January, 2006.

13. “What is the adult β-cell precursor?”. Cell Biology & Physiology Program, Cell and Molecular Biology Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, PA, January, 2006.

14. “Cell Turnover Lineage Analysis of the Endocrine Pancreas: Adult Beta-Cells Exhibit Equal Proliferation Potential.” The Joseph Stokes, Jr. Research Institute Annual Scientific

Symposium, Children's Hospital of Philadelphia, Bryn Mawr, PA, April, 2006.

15. “Adaptive Beta-cell Growth as a Function of Age”. Endocrine Division Conference, Children's Hospital of Philadelphia, Philadelphia, PA, May 2006.

16. “Growth and Regeneration of Adult β-Cells in the Islets of Langerhans”. Annual Meeting,

Delaware Chapter of the Juvenile Diabetes Research Foundation, Wilmington DE, June, 2006.

17. “Beta-cell Turnover in Mice: Cellular Fate and Progenitors”. Cell Biology & Physiology Program, Cell and Molecular Biology Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, PA, September, 2006.

18. “Adaptive Beta Cell Proliferation is Greatly Limited with Advanced Age.” Type 2 Diabetes Mellitus Retreat, Institute for Diabetes, Obesity, and Metabolism, and the Division of Endocrinology, Diabetes, and Metabolism Seminar Series, University of Pennsylvania School of Medicine, Philadelphia, PA, September, 2006.

19. “Turnover of Beta-Cells in the Islets of Langerhans: Cellular Progenitors and Molecular Regulation.” Cell & Gene Therapy Research Affinity Group Seminar, Children's Hospital of Philadelphia, Philadelphia, PA, September, 2006.

20. “Growth of the Islets of Langerhans.” Stokes Faculty Luncheon, Children's Hospital of

Philadelphia, Philadelphia, PA, October, 2006.

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21. “Beta-Cell Turnover: Cellular Progenitors and Molecular Regulation of Proliferation” Annual Spring Symposium, University of Pennsylvania Institute of Diabetes Obesity and Metabolism, Philadelphia, PA, March, 2007

22. “Growth and Regeneration of Adult Beta Cells of the Islets of Langerhans Does Not Involve Specialized Progenitors.” Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, October, 2007

23. “Growth and regeneration of adult beta cells: Does it involve specialized progenitors”. Developmental Biology Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, PA, October, 2008.

24. “Growth and regeneration of adult beta cells: Does it involve specialized progenitors?”. City of Hope 8th Annual Levine Symposium, Newport Beach, CA, January, 2008.

25. “Growth and Regeneration of Adult β-Cells in the Islets of Langerhans”. “Dive for a Cure”, Research Update, Eastern Pennsylvania Chapter of the Juvenile Diabetes Research Foundation, Adventure Aquarium, Camden, NJ, March, 2008.

26. “Research Update”. Endocrine Division Conference, Children's Hospital of Philadelphia,

Philadelphia, PA, May 2008.

27. “Growth and Regeneration of Adult Beta Cells of the Islets of Langerhans Does Not Involve Specialized Progenitors.” Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA, June, 2008.

28. “Growth and Regeneration of Adult β-Cells in the Islets of Langerhans.” Stokes Summer Student Research Colloquium, Children's Hospital of Philadelphia, Philadelphia, PA, June, 2008.

29. “Beta Cell Regeneration.” Neonatology Research Seminar, Department of Pediatrics,

University of Pennsylvania School of Medicine, Philadelphia, PA, September, 2008

30. “Where do adult β-cells come from? ”. Developmental Biology Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, PA, October, 2008.

31. “β-Cell Regeneration: Cellular Progenitors & Regulation of Cell Cycle Entry. A Pediatrician's Perspective”. Research Conference, Physician Scientist Development, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, February, 2009.

32. “Cell Cycle Regulation Of Islet Growth”. Islet Biology Retreat: Translating Islet Biology into Clinical Therapy. Institute for Diabetes, Obesity and Metabolism (IDOM) and the Institute for Regenerative Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA. September, 2009.

33. “Why study β-cell regeneration?”. Endocrine Division Conference, Children's Hospital of Philadelphia, Philadelphia, PA, October 2009.

34. “Let Them Eat Cake: New Cures for Diabetes.” Board of Trustees Bi-annual Scientific Symposium, Children's Hospital of Philadelphia, Philadelphia, PA, November, 2009.

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35. “Regeneration of the Pancreatic Beta Cells: A Fundamental Challenge for Canine & Human Diabetes.”Grand Rounds, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, December, 2009.

36. “Kinetics of Adult Beta Cell Turnover”. Stem Cell Club, Institute of Regenerative Medicine, University of Pennsylvania School of Medicine, May 2010.

37. “Diabetes Research: Cutting Edge Tools to Interrogate Where the Pancreatic Beta Cells Come From”. College Biochemistry Seminar Series, Department of Biochemistry, University of

Pennsylvania, November, 2010.

38. “Studies To Elucidate The Pathological Basis Of Cystic Fibrosis Related Diabetes”. Pulmonary Grand Rounds, Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, November, 2010.

39. “Developmental Biology of Pancreatic Beta-Cells”. Developmental, Stem Cell and Regenerative Biology Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, PA, November, 2010.

40. “Beta Cell Regeneration: Challenges and Opportunities”, Endocrine Division Conference,

Children's Hospital of Philadelphia, Philadelphia, PA, May 2011.

41. “Type 1 Diabetes”, Step Out: Walk to Stop Diabetes Luncheon ADA Houston, June 2011.

42. “The Texas Children’s Diabetes Center”, JDRF Houston, September 2011.

43. “Studies to elucidate the pathological basis of cystic fibrosis related diabetes”. Pulmonary

Grand Rounds, Baylor College of Medicine, Houston, Texas, September 2011.

44. “Experimental Avenues to Treat Type 1 Diabetes: A Pediatrician's Perspective”, Pediatric Grand Rounds, Baylor College of Medicine, Houston, Texas, September 2011..

45. The Texas Children’s Diabetes Center”, Texas Children’s All Staff Meeting, October 2011.

46. “Beta Cell Regeneration: Challenges and Opportunities”, Molecular and Cellular Biology Wednesday Seminar Series, Baylor College of Medicine, Houston, Texas, November 2011.

47. “Beta Cell Regeneration: Challenges and Opportunities”, Texas Children’s Hospital Pathology Research Conference Baylor College of Medicine, Houston, Texas, December 2011.

48. “Beta Cell Regeneration”, NIH DRC Research Symposium, Baylor College of Medicine, Houston, Texas, January 2012.

49. “Keeping your child happy in a fast food world”, Co-Presented with Dr. Mark Gilger, Young Presidents Organization, Texas Children’s Hospital, March 2012.

50. “Beta cell regeneration for type 1 diabetes: challenges and opportunities”, McNair Medical Institute Symposium, Baylor College of Medicine, Houston, Texas, April 2012.

51. “Effects of Diabetes in the Houston Community”, 2012 Tour de Cure Corporate Recruitment, BVNA Compass Stadium, Houston, Texas, June 2012.

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52. “Beta cells & immunology for type 1 diabetes: challenges and opportunities”, McNair Medical Institute Retreat, Houston, Texas, June 2012.

53. “Beta cell regeneration as a novel therapeutic strategy for diabetes”, Cellular & Molecular Biology of Disease Course GS-CB-423, Baylor College of Medicine, Houston, Texas, September 2012.

54. “Controversies Regarding the Generation of Pancreatic Beta Cells, Endocrine Grand Rounds, , Baylor College of Medicine, Houston, Texas, September 2012.

55. “Diabetes research. Effects of aging upon regeneration of the pancreatic endocrine cells. Trick or treat?”. Research Seminar, Huffington Center on Aging, Baylor College of Medicine, Houston, Texas, October 2012.

56. “Developing a healthy physician leader-administrator partnership”, Texas Children’s

Ambulatory Leadership Retreat, Houston, Texas, November 2012.

57. “Diabetes Research: Leveraging Autoimmunity to Interrogate the Regenerative Capacity of Pancreatic Beta Cells, Graduate Program in Immunology Research Seminar, Baylor College of Medicine, Houston, Texas, November, 2012

58. Diabetes research. Effects of aging upon regeneration of the pancreatic endocrine cells. Endocrinology Fellows Research Symposium, Baylor College of Medicine, Houston, Texas, February, 2013

59. “Interrogating the regenerative capacity of pancreatic beta cells”, McNair Medical Institute

Symposium, Baylor College of Medicine, Houston, Texas, April 2013.

60. “Pediatric Hypothyroidism: Childhood Disease Presentation and Management Throughout the Age Spectrum, Pediatric Endocrinology Fellows Seminar Series”, Baylor College of Medicine, Houston, Texas, April, 2013.

61. “Pancreas organ donation to advance type 1 diabetes research”. Pediatric Endocrinology Seminar, Baylor College of Medicine, Houston, Texas, June, 2013

62. “Insulin Secretion – Mechanisms And Pathophysiology”. Pediatric Endocrinology Fellows Seminar Series”, Baylor College of Medicine, Houston, Texas, October, 2013.

63. “Type 1 Diabetes: Past, Present, and Future”, Annual Meeting of the Medical Staff, Texas Children’s Hospital, Houston, Texas, November 2013.

64. “Innovative acute care nursing – service line partnerships to deliver expert patient-centered care for hospitalized children with type 1 diabetes patients at TCH”. Texas Children’s Hospital

Nursing Congress, Houston Texas, February 2014

65. “Beta cell regeneration for patients with type 1 diabetes: challenges and opportunities”, McNair Medical Institute Symposium, Baylor College of Medicine, Houston, Texas, April 2014.

66. “Neonatal Diabetes”. Research Conference, Pediatric Critical Care, Baylor College of

Medicine, Houston, Texas, July 2014.

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67. “Canine Diabetes: A Model of Human Type 1 Diabetes?”, T1D Research Group Meeting, Baylor College of Medicine, Houston, Texas, October 2014.

68. “Pediatric Hypothyroidism: Childhood Disease Presentation and Management Throughout the Age Spectrum”, Texas Children’s West Campus “Lunch and Learn”, Katy, Texas, January 2015.

69. “Medical nutrition therapy for people with type 1 diabetes: fact versus fiction”, Research Conference, Pediatric Diabetes and Endocrinology, Baylor College of Medicine, Houston,

Texas, January 2015.

70. “Interrogating the regenerative capacity of human beta cells in patients with type 1 diabetes”, Research Conference, Pediatric Diabetes and Endocrinology, Baylor College of Medicine, Houston, Texas, February 2015.

71. “Beta cell regeneration for patients with type 1 diabetes: challenges and opportunities”, McNair Medical Institute Symposium, Baylor College of Medicine, Houston, Texas, April 2015.

72. “Introduction: Envisioning the future of type 1 diabetes research” Research Symposia, Inaugural McNair Medical Institute Type 1 Diabetes Retreat, Baylor College of Medicine,

Houston, TX, September 2015

73. “Medical nutrition therapy for people with type 1 diabetes: fact versus fiction”, Fellow’s Research Conference, Pediatric Diabetes and Endocrinology, Baylor College of Medicine, Houston, Texas, November 2015.

74. “Interrogating the Regenerative Capacity of Pancreatic Islets: Birth and Death”, MD-PhD Program Biomedical Sciences Research Seminar, Baylor College of Medicine, Houston, Texas, November 2015.

75. “Beta cell regeneration: searching for therapeutic targets capable of expanding beta cells in patients with type 1 diabetes”, McNair Medical Institute Symposium, Baylor College of Medicine, Houston, Texas, April 2016.

76. “Vision Zero: Reducing Preventable Harm for People with Type 1 Diabetes”, Section Meeting, Pediatric Diabetes and Endocrinology, Baylor College of Medicine, Houston, Texas, March

2016.

77. “Carbs vs. Fat: What to Eat?”, Ambassadors On Call Luncheon, Texas Children’s Hospital, Houston, Texas, April 2016.

78. “Carbs vs. Fat: What to Eat?”, Fellow’s Research Conference, Pediatric Diabetes and

Endocrinology, Baylor College of Medicine, Houston, Texas, November 2016.

79. “Interrogating the regenerative response to autoimmunity of human beta cells in patients with type 1 diabetes”, The Center for Human Immunobiology Scientific Seminar, Baylor College of Medicine, Houston, Texas, November 2016.

Organizing roles in scientific meetings:

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1. Co-Chair, Research Symposia, Title: "The Unfolded Protein Response (UPR) and Human Disease, University of Pennsylvania School of Medicine, Philadelphia, PA. April 2010. Co-

2. Member, Organizing Committee, McNair Medical Institute Annual Scientific Symposium,

Baylor College of Medicine, Houston, TX, 2012.

3. Member, Organizing Committee, McNair Medical Institute Annual Scientific Symposium, Baylor College of Medicine, Houston, TX, 2013.

4. Member, Organizing Committee, McNair Medical Institute Annual Scientific Symposium,

Baylor College of Medicine, Houston, TX, 2014.

5. Co-Chair, Research Symposia, Inaugural McNair Medical Institute Type 1 Diabetes Retreat, Baylor College of Medicine, Houston, TX, 2015.

6. Co-Chair, Research Symposia, Second Annual McNair Medical Institute Type 1 Diabetes

Retreat, Baylor College of Medicine, Houston, TX, 2016.

Moderator of discussion in scientific meetings:

1. Co-chair, “Humanized Mouse Models for Studying Disease”, PAS State of the Art Plenary 2014 Pediatric Academic Societies Meeting, Vancouver, Canada, May, 2014.

2. Moderator, Guided Audio Poster Tour, “Novel Signaling Pathways in the Islet “ American Diabetes Association’s 74th Scientific Sessions, San Francisco, CA, June 2014.

3. Moderator, “"Pushing the Boundaries of Knowledge to Advance Therapies for T1D”, T1D Exchange Annual Meeting, Boston, MA, October 2016.

C. Publications

1. Full papers:

a. Published in peer review journals:

1. Friedman JS, Cofer CL, Anderson CL, Kushner JA, Gray PP, Chapman GE, Stuart MC, Lazarus L, Shine J, Kushner PJ: High expression in mammalian cells without amplication. Bio/Technology 7(47): 359-362, April 1989. (>50 citations)

2. Zhou QY, Grandy DK, Thambi L, Kushner JA, Van Tol HH, et al. Cloning and expression of human and rat D1 dopamine receptors. Nature. 1990 Sep 6;347(6288):76-80. PubMed PMID:

2168520.

3. Mellon SH, Kushner JA, Vaisse C. Expression and regulation of adrenodoxin and P450scc mRNA in rodent tissues. DNA Cell Biol. 1991 Jun;10(5):339-47. PubMed PMID: 1863358.

4. Kushner JA, Ye J, Schubert M, Burks DJ, Dow MA, et al. Pdx1 restores beta cell function in Irs2 knockout mice. J Clin Invest. 2002 May;109(9):1193-201. PubMed PMID: 11994408; PubMed Central PMCID: PMC150960.

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5. Schubert M, Brazil DP, Burks DJ, Kushner JA, Ye J, et al. Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci. 2003 Aug 6;23(18):7084-92. PubMed PMID: 12904469.

6. Kushner JA, Haj FG, Klaman LD, Dow MA, Kahn BB, et al. Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice. Diabetes. 2004 Jan;53(1):61-6. PubMed PMID: 14693698.

7. Pawlak DB, Kushner JA, Ludwig DS. Effects of dietary glycaemic index on adiposity, glucose homoeostasis, and plasma lipids in animals. Lancet. 2004 Aug 28-Sep 3;364(9436):778-85. PubMed PMID: 15337404.

8. Lin X, Taguchi A, Park S, Kushner JA, Li F, et al. Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. J Clin Invest. 2004 Oct;114(7):908-16.

PubMed PMID: 15467829; PubMed Central PMCID: PMC518668.

9. Yi X, Schubert M, Peachey NS, Suzuma K, Burks DJ, et al. Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells. J Neurosci. 2005 Feb 2;25(5):1240-8. PubMed PMID: 15689562.

10. Kushner JA, Ciemerych MA, Sicinska E, Wartschow LM, Teta M, et al. Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth. Mol Cell Biol. 2005 May;25(9):3752-62. PubMed PMID: 15831479; PubMed Central PMCID: PMC1084308.

11. Teta M, Long SY, Wartschow LM, Rankin MM, Kushner JA. Very slow turnover of beta-cells in

aged adult mice. Diabetes. 2005 Sep;54(9):2557-67. PubMed PMID: 16123343.

12. Kushner JA, Simpson L, Wartschow LM, Guo S, Rankin MM, et al. Phosphatase and tensin homolog regulation of islet growth and glucose homeostasis. J Biol Chem. 2005 Nov 25;280(47):39388-93. PubMed PMID: 16170201.

13. Kushner JA. Beta-cell growth: an unusual paradigm of organogenesis that is cyclin D2/Cdk4 dependent. Cell Cycle. 2006 Feb;5(3):234-7. PubMed PMID: 16410729.

14. Sherry NA, Kushner JA, Glandt M, Kitamura T, Brillantes AM, et al. Effects of autoimmunity and immune therapy on beta-cell turnover in type 1 diabetes. Diabetes. 2006 Dec;55(12):3238-45.

PubMed PMID: 17130466.

15. Ablamunits V, Sherry NA, Kushner JA, Herold KC. Autoimmunity and beta cell regeneration in mouse and human type 1 diabetes: the peace is not enough. Ann N Y Acad Sci. 2007 Apr;1103:19-32. PubMed PMID: 17376841.

16. Teta M, Rankin MM, Long SY, Stein GM, Kushner JA. Growth and regeneration of adult beta cells does not involve specialized progenitors. Dev Cell. 2007 May;12(5):817-26. PubMed PMID: 17488631.

17. Podcheko A, Northcott P, Bikopoulos G, Lee A, Bommareddi SR, et al. Identification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survival. Mol Cell Biol. 2007 Sep;27(18):6484-96. PubMed PMID: 17636024; PubMed Central PMCID: PMC2099606.

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18. Kiel MJ, He S, Ashkenazi R, Gentry SN, Teta M, et al. Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU. Nature. 2007 Sep 13;449(7159):238-42. PubMed PMID: 17728714; NIHMSID: NIHMS73699; PubMed Central PMCID: PMC2633872.

19. Sherry NA, Chen W, Kushner JA, Glandt M, Tang Q, et al. Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells. Endocrinology. 2007 Nov;148(11):5136-44. PubMed PMID: 17673522.

20. Kushner JA, Lawrence HP, Shoval I, Kiss TL, Devins GM, et al. Development and validation of a Patient-Reported Oral Mucositis Symptom (PROMS) scale. J Can Dent Assoc. 2008 Feb;74(1):59. PubMed PMID: 18298885.

21. Akirav E, Kushner JA, Herold KC. Beta-cell mass and type 1 diabetes: going, going, gone?. Diabetes. 2008 Nov;57(11):2883-8. PubMed PMID: 18971435; PubMed Central PMCID:

PMC2570380.

22. Szabolcs M, Keniry M, Simpson L, Reid LJ, Koujak S, et al. Irs2 inactivation suppresses tumor progression in Pten+/- mice. Am J Pathol. 2009 Jan;174(1):276-86. PubMed PMID: 19095950; PubMed Central PMCID: PMC2631340.

23. Rankin MM, Kushner JA. Adaptive beta-cell proliferation is severely restricted with advanced age. Diabetes. 2009 Jun;58(6):1365-72. PubMed PMID: 19265026; PubMed Central PMCID: PMC2682671.

24. Granger A, Kushner JA. Cellular origins of beta-cell regeneration: a legacy view of historical controversies. J Intern Med. 2009 Oct;266(4):325-38. PubMed PMID: 19765178; NIHMSID: NIHMS501505; PubMed Central PMCID: PMC3762574.

25. He LM, Sartori DJ, Teta M, Opare-Addo LM, Rankin MM, et al. Cyclin D2 protein stability is regulated in pancreatic beta-cells. Mol Endocrinol. 2009 Nov;23(11):1865-75. PubMed PMID:

19628581; PubMed Central PMCID: PMC2775938.

26. Kushner JA, Weir GC, Bonner-Weir S. Ductal origin hypothesis of pancreatic regeneration under attack. Cell Metab. 2010 Jan;11(1):2-3. PubMed PMID: 20085728; NIHMSID: NIHMS501493; PubMed Central PMCID: PMC3762572.

27. Liang L, Guo WH, Esquiliano DR, Asai M, Rodriguez S, et al. Insulin-like growth factor 2 and the insulin receptor, but not insulin, regulate fetal hepatic glycogen synthesis. Endocrinology. 2010 Feb;151(2):741-7. PubMed PMID: 20032056; PubMed Central PMCID: PMC2817628.

28. Perl S, Kushner JA, Buchholz BA, Meeker AK, Stein GM, et al. Significant human beta-cell turnover is limited to the first three decades of life as determined by in vivo thymidine analog incorporation and radiocarbon dating. J Clin Endocrinol Metab. 2010 Oct;95(10):E234-9. PubMed PMID: 20660050; PubMed Central PMCID: PMC3050099.

29. Rankin MM, Kushner JA. Aging induces a distinct gene expression program in mouse islets. Islets. 2010 Nov-Dec;2(6):345-52. PubMed PMID: 21099336; PubMed Central PMCID: PMC3062249.

30

30. Tuttle AH, Rankin MM, Teta M, Sartori DJ, Stein GM, et al. Immunofluorescent detection of two thymidine analogues (CldU and IdU) in primary tissue. J Vis Exp. 2010 Dec 7;(46)PubMed PMID: 21178965; PubMed Central PMCID: PMC3159664.

31. Soleimanpour SA, Crutchlow MF, Ferrari AM, Raum JC, Groff DN, et al. Calcineurin signaling regulates human islet {beta}-cell survival. J Biol Chem. 2010 Dec 17;285(51):40050-9. PubMed PMID: 20943662; PubMed Central PMCID: PMC3000987.

32. Akirav EM, Baquero MT, Opare-Addo LW, Akirav M, Galvan E, et al. Glucose and inflammation control islet vascular density and beta-cell function in NOD mice: control of islet vasculature and vascular endothelial growth factor by glucose. Diabetes. 2011 Mar;60(3):876-83. PubMed PMID: 21307078; PubMed Central PMCID: PMC3046848.

33. Kushner JA. Development Esophageal stem cells, where art thou?. Science. 2012 Aug 31;337(6098):1051-2. PubMed PMID: 22936766; NIHMSID: NIHMS501490; PubMed Central PMCID: PMC3762587.

34. Rieck S, Zhang J, Li Z, Liu C, Naji A, et al. Overexpression of hepatocyte nuclear factor-4α

initiates cell cycle entry, but is not sufficient to promote β-cell expansion in human islets. Mol

Endocrinol. 2012 Sep;26(9):1590-602. PubMed PMID: 22798294; PubMed Central PMCID: PMC3434530.

35. Chitnis NS, Pytel D, Bobrovnikova-Marjon E, Pant D, Zheng H, et al. miR-211 is a prosurvival microRNA that regulates chop expression in a PERK-dependent manner. Mol Cell. 2012 Nov 9;48(3):353-64. PubMed PMID: 23022383; NIHMSID: NIHMS406732; PubMed Central PMCID: PMC3496065.

36. Gao Y, Sartori DJ, Li C, Yu QC, Kushner JA, et al. PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis. Mol Cell Biol. 2012 Dec;32(24):5129-39. PubMed PMID: 23071091; PubMed Central PMCID: PMC3510549.

37. Kushner JA. The role of aging upon β cell turnover. J Clin Invest. 2013 Mar;123(3):990-5.


38. Rankin MM, Wilbur CJ, Rak K, Shields EJ, Granger A, et al. β-Cells are not generated in

pancreatic duct ligation-induced injury in adult mice. Diabetes. 2013 May;62(5):1634-45. PubMed PMID: 23349489; PubMed Central PMCID: PMC3636617.

39. Sartori DJ, Wilbur CJ, Long SY, Rankin MM, Li C, et al. GATA factors promote ER integrity and

β-cell survival and contribute to type 1 diabetes risk. Mol Endocrinol. 2014 Jan;28(1):28-39.


40. Hicks KA, Kushner JA, Heptulla R, Ham JN. Permanent neonatal diabetes mellitus in monozygotic twins achieving low-dose sulfonylurea therapy. J Pediatr Endocrinol Metab. 2014

Jan;27(1-2):135-8. PubMed PMID: 23959658.

41. Soleimanpour SA, Gupta A, Bakay M, Ferrari AM, Groff DN, et al. The diabetes susceptibility gene Clec16a regulates mitophagy. Cell. 2014 Jun 19;157(7):1577-90. PubMed PMID: 24949970; NIHMSID: NIHMS600455; PubMed Central PMCID: PMC4184276.

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42. Elahi D, Mirmira RG, Kushner JA. Editorial: in praise of scientific review officers. Mol Endocrinol. 2014 Jul;28(7):987-8. PubMed PMID: 24983311; PubMed Central PMCID: PMC5414830.

43. Kushner JA, MacDonald PE, Atkinson MA. Stem cells to insulin secreting cells: two steps forward and now a time to pause?. Cell Stem Cell. 2014 Nov 6;15(5):535-6. PubMed PMID: 25517460.

44. Shields EJ, Lam CJ, Cox AR, Rankin MM, Van Winkle TJ, et al. Extreme Beta-Cell Deficiency in Pancreata of Dogs with Canine Diabetes. PLoS One. 2015;10(6):e0129809. PubMed PMID:


45. Cox AR, Lam CJ, Bonnyman CW, Chavez J, Rios JS, et al. Angiopoietin-like protein 8 (ANGPTL8)/betatrophin overexpression does not increase beta cell proliferation in mice. Diabetologia. 2015 Jul;58(7):1523-31. PubMed PMID: 25917759; NIHMSID: NIHMS687933;

PubMed Central PMCID: PMC4473078.

46. Michels A, Zhang L, Khadra A, Kushner JA, Redondo MJ, et al. Prediction and prevention of type 1 diabetes: update on success of prediction and struggles at prevention. Pediatr Diabetes. 2015 Nov;16(7):465-84. PubMed PMID: 26202050; NIHMSID: NIHMS709842; PubMed Central

PMCID: PMC4592445.

47. Yu Q, Zhao B, Gui J, Katlinski KV, Brice A, et al. Type I interferons mediate pancreatic toxicities of PERK inhibition. Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15420-5. PubMed PMID: 26627716; PubMed Central PMCID: PMC4687574.

48. Ackerman KG, Lee B, Kushner JA. Dissatisfaction with maintenance of certification in academic pediatrics. Pediatr Res. 2016 Feb;79(2):240-2. PubMed PMID: 26421351.

49. Burns AM, Kushner JA, Ward MA, Turner TL, Kline MW, et al. Strengthening the Pipeline for Clinician-Scientists: The Pediatrician-Scientist Training and Development Program at Texas

Children's Hospital. J Pediatr. 2016 May;172:5-6.e5. PubMed PMID: 27112081.

50. Cox AR, Lam CJ, Rankin MM, King KA, Chen P, et al. Extreme obesity induces massive beta cell expansion in mice through self-renewal and does not alter the beta cell lineage. Diabetologia. 2016 Jun;59(6):1231-41. PubMed PMID: 27003683; PubMed Central PMCID:

PMC4869735.

51. Cox AR, Barrandon O, Cai EP, Rios JS, Chavez J, et al. Resolving Discrepant Findings on

ANGPTL8 in β-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin

Controversy. PLoS One. 2016;11(7):e0159276. PubMed PMID: 27410263; PubMed Central

PMCID: PMC4943640.

52. Bonifacio E, Mathieu C, Nepom GT, Ziegler AG, Anhalt H, et al. Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity. Diabetologia. 2017 Jan;60(1):35-38. PubMed PMID: 27785529; NIHMSID: NIHMS878565;

PubMed Central PMCID: PMC5516264.

53. Bansal N, Hampe CS, Rodriguez L, O'Brian Smith E, Kushner J, et al. DPD epitope-specific glutamic acid decarboxylase (GAD)65 autoantibodies in children with Type 1 diabetes. Diabet Med. 2017 May;34(5):641-646. PubMed PMID: 26802570; NIHMSID: NIHMS754071; PubMed

Central PMCID: PMC4958605.

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54. Cox AR, Lam CJ, Rankin MM, Rios JS, Chavez J, et al. Incretin Therapies Do Not Expand β-

Cell Mass or Alter Pancreatic Histology in Young Male Mice. Endocrinology. 2017 Jun

1;158(6):1701-1714. PubMed PMID: 28323942; PubMed Central PMCID: PMC5460937.

55. O'Kell AL, Wasserfall C, Catchpole B, Davison LJ, Hess RS, et al. Comparative Pathogenesis of Autoimmune Diabetes in Humans, NOD Mice, and Canines: Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked?. Diabetes. 2017 Jun;66(6):1443-1452. PubMed PMID:


56. Lam CJ, Jacobson DR, Rankin MM, Cox AR, Kushner JA. β Cells Persist in T1D Pancreata

Without Evidence of Ongoing β-Cell Turnover or Neogenesis. J Clin Endocrinol Metab. 2017

Aug 1;102(8):2647-2659. PubMed PMID: 28323930; PubMed Central PMCID: PMC5546851.

57. Cox AR, Kushner JA. Area IV Knockout Reveals How Pdx1 Is Regulated in Postnatal β-Cell

Development. Diabetes. 2017 Nov;66(11):2738-2740. PubMed PMID: 29061659; PubMed Central PMCID: PMC5652604.

58. Garg SK, Henry RR, Banks P, Buse JB, Davies MJ, et al. Effects of Sotagliflozin Added to Insulin in Patients with Type 1 Diabetes. N Engl J Med. 2017 Dec 14;377(24):2337-2348. PubMed PMID: 28899222.

59. Lam CJ, Cox AR, Jacobson DR, Rankin MM, Kushner JA. Highly Proliferative α-Cell-Related

Islet Endocrine Cells in Human Pancreata. Diabetes. 2018 Apr;67(4):674-686. PubMed PMID: 29326366; PubMed Central PMCID: PMC5860854.

60. Danne T, Cariou B, Banks P, Brandle M, Brath H, et al. HbA<sub>1c</sub> and Hypoglycemia Reductions at 24 and 52 Weeks With Sotagliflozin in Combination With Insulin in Adults With Type 1 Diabetes: The European inTandem2 Study. Diabetes Care. 2018 Sep;41(9):1981-1990. PubMed PMID: 29937431.

61. Buse JB, Garg SK, Rosenstock J, Bailey TS, Banks P, et al. Sotagliflozin in Combination With Optimized Insulin Therapy in Adults With Type 1 Diabetes: The North American inTandem1 Study. Diabetes Care. 2018 Sep;41(9):1970-1980. PubMed PMID: 29937430; PubMed Central PMCID: PMC6105319.

62. Pandey R, Bakay M, Hain HS, Strenkowski B, Elsaqa BZB, et al. CLEC16A regulates splenocyte and NK cell function in part through MEK signaling. PLoS One.

2018;13(9):e0203952. PubMed PMID: 30226884; PubMed Central PMCID: PMC6143231.

63. Kohn JR, Hilliard ME, Lyons SK, Fox KA, Kushner JA. Identifying and addressing gaps in reproductive health education for adolescent girls with type 1 diabetes. PLoS One. 2018;13(11):e0206102. PubMed PMID: 30399169; PubMed Central PMCID: PMC6219771.

Google H Index: 34 as of September 27, 2018. 6143 citations, 2915 since 2013.

2. Other full papers:

a. Published without review by peer group:

b. In review:

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1. Carol J. Lam, Ani Chatterjee, Emily Shen, Aaron R. Cox, and Jake A. Kushner. Low level insulin expression within abundant non-beta islet endocrine cells in long-standing type 1 diabetes. Submitted to Dia

2. Bakay M, Pandey R, Yoeun S, Li Y, Kushner JA, Orange JS, Hakonarson H. The type 1 diabetes susceptibility gene CLEC16A restrains NK cell function by modulating expression of NK receptors via autophagy. Submitted.

3. Abstracts given during the last three years:

1. Hicks KA, Correa A, Gunn S, Karaviti L, Herold K, Kushner JA. Accelerated decline in β cell function causes fulminant type 1 diabetes mellitus in very young children. Texas Children’s Pediatric Fellows Research Day Poster 2013

2. Cox AR, Lam CJ, Rankin MM, King KK, Li C, Kushner JA: Beta Cell Expansion is Governed by Intrinsic Replication “Speed Limit”, even in Response to Extreme Metabolic Stimuli. American

Diabetes Association 75th Scientific Sessions, June 2014.

3. Cox AR, Lam CJ, Bonnyman CW, Chavez J, Rios JS, Kushner JA: ANGPTL8/Betatrophin does

not increase beta cell proliferation. A-BC Islet Workshop, February 2015.

4. Lam, C.J., Jacobson, D.R., Rankin, M.M., Cox, A.R., Kushner, J.A.: High islet endocrine cell proliferation in adolescent T1D and non-diabetic pancreata. JDRF nPOD 7th Annual Scientific Meeting. February 2015.

5. Schupp JR, Kushner JA. Reproductive Health Education for Adolescent Girls with Diabetes Mellitus. TexMed (Texas Medical Association Annual Meeting). Austin, TX. May 2, 2015. Oral Presentation.

6. Schupp J, Kushner JA. Reproductive Health Education for Adolescent Girls with Diabetes Mellitus. Baylor College of Medicine Annual Quality Improvement and Patient Safety

Conference. Baylor College of Medicine, Houston, TX. May 14, 2015.

7. Schupp J, Kushner JA. Reproductive Health Education for Adolescent Girls with Diabetes Mellitus. TexMed (Texas Medical Association Annual Meeting) Quality Improvement Poster Session. Austin, TX. May 2, 2015. Best Poster, 3rd Place Overall

8. Schupp J, Kushner JA. Reproductive Health Education for Adolescent Girls with Diabetes Mellitus. James K Alexander Medical Student Research Symposium, Baylor College of Medicine, Houston, TX. March 5, 2015.

9. Burns, Audrea M; Kushner, Jake A; Ward, Mark A; Turner, Teri L; Kline, Mark W; Orange, Jordan S; Developing a Comprehensive Approach to Training Pediatrician-Scientists at Texas Children’s Hospital and Baylor College of Medicine: The Pediatrician-Scientist Training & Development Program, Academic Pediatrics, 16, 6, e38-e39 2016, Elsevier

10. Lam, C.J., Jacobson, D.R., Rankin, M.M., Cox, A.R., Kushner, J.A.: A novel, highly proliferative islet endocrine cell population in human pancreata. JDRF nPOD 8th Annual Scientific Meeting.

February 2016

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11. Alwazeer, Mouhammad Rateb; DeSalvo, Daniel Joseph; McKay, Siripoom Vudhipoom; Redondo, Maria Jose; Smith, EO'brian; Strumph, Paul Sumner; Kushner, Jake Alden; SUN-686: Daily Consumption of Almonds Does Not Improve Postprandial Glucose Excursion in Pediatric

Type 1 Diabetes (T1D), 2016

12. Burns, Audrea M; Kushner, Jake A; Ward, Mark A; Turner, Teri L; Kline, Mark W; Orange, Jordan S; Development Program at Texas Children’s Hospital 2016

13. Cox AR, Lam CJ, Rankin MM, King KA, Chen P, Martinez R, Li C, Kushner JA: Extreme obesity induces massive beta cell expansion through self-renewal and does not alter the beta cell

lineage. A-BC Islet Workshop, February 2016.

14. Cox AR, Lam CJ, Rankin MM, Kushner JA: Beta cell expansion occurs by self-renewal, even in response to extreme metabolic stimuli. Pediatric Research & Fellows’ Symposium, March 2016.

15. Cox AR, Lam CJ, Rankin MM, Kushner JA: Beta cell expansion occurs by self-renewal, even in

response to extreme metabolic stimuli. Fourth Annual McNair Symposium, April 2016.

16. Cox AR, Lam CJ, Rankin MM, Rios JS, Chavez J, Bonnyman CW, King KA, Wells RE, Kushner JA: Incretin therapy does not generate beta cells nor alter pancreatic histology in young mice.

American Diabetes Association 77th Scientific Sessions, June 2016.

17. Lam, C.J., Rankin M.M. King K.A., Cox, A.R., Shook, B.C., Kushner, J.A.: Adaptive proliferation of pancreatic glucagon-containing alpha cells is severely reduced with age. American Diabetes Association 76th Scientific Sessions, June 2016.

18. Cox AR, Lam CJ, Rankin MM, Ren JL, Mohanty A, Devarajan M, Kushner JA: Neogenesis does not contribute to maintenance or attempted regeneration of beta cells in aged mice. American

Diabetes Association 77th Scientific Sessions, June 2016.

19. Cox AR, Lam CJ, Rankin MM, Kushner JA: Beta cell expansion occurs by self-renewal, even in response to extreme metabolic stimuli. American Diabetes Association 77th Scientific Sessions,

June 2016.

4. Books:

a. Complete books written: N/A

b. Books edited:

Rudolph’s Pediatrics, 23rd Edition. Section Editor: Disorders of the Endocrine System. Editor-In-Chief Mark W. Kline. Associate Editors: Susan Blaney, Angelo Giardino, Jordan Orange, Dan Penny, Gordon Schutze and Lara Shekerdemian.

5. Other works communicating research results to scientific colleagues:

Endocrine Today. July 2016. Jake A. Kushner. Structured, coordinated approach needed for pediatric diabetes patients transitioning to adult care. Counterpoint: The resources are not in place to transition pediatric patients to adult care at age 18 years.

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6. Other works communicating research results to general public:

McCarthy M, Kushner JA. The Everything Parent's Guide To Children With Juvenile Diabetes: Reassuring Advice for Managing Symptoms and Raising a Happy, Healthy Child.

Adams Media. ISBN: 1598692461 (technical review).

McCarthy M, Anderson, BJ, Kushner JA. Raising Teens with Diabetes: A Survival Guide for Parents. Spry Publishing. ISBN: 1938170202 (technical review).

Podcast: “The Livin’ La Vida Low-Carb Show with Jimmy Moore”, Episode 1262: Dr. Jake Kushner Is Making Waves In The Diabetes Community By Treating T1 With LCHF. May 2017.

Radio Interview: “Pet Buzz”. September 2015. WSRQ Radio.

Podcast: “The Sigma Nutrition Podcast”, SNR #186: Dr. Jake Kushner, MD – Nutrition for

Type 1 Diabetes. July 2017.

III. TEACHING INFORMATION

A. Didactic course work:

1. Courses taught at Current institution:

Current:

Past:

Co-director, Stokes Summer Student Research Colloquium, Children's Hospital of

Philadelphia. Total hours: 12 each summer plus preparation. 2004-2010.

Course Co-Director, CAMB 530. The Cell Cycle and Cancer. Total teaching: 26 hours per year plus preparation and administrative time. 2009, 2010

Guest Lecturer, CAMB 542. Topics and Methods in Molecular Medicine. MD/PHD student Seminar series in the Cellular And Molecular Biology Graduate Program. Total teaching hours: 2 plus preparation. 2009, 2010.

Guest Lecturer, CAMB 632. Seminar series in the Cellular And Molecular Biology Graduate Program. Total teaching hours: 2 plus preparation. 2009-2011

Instructor, CAMB 605. Faculty member of first year seminar series in the Cellular And Molecular Biology Graduate Program. Total teaching hours: 36 plus preparation. 2005.

Guest Lecturer, CAMB 632. Seminar series in the Cellular And Molecular Biology Graduate Program. Total teaching hours: 2 plus preparation. 2005

Instructor, Responsible Conduct of Research, Children's Hospital of Philadelphia, Total Hours: 2 plus preparation per year. 2005-2006

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Course Co-Director, CAMB 632. Seminar series in the Cellular And Molecular Biology Graduate Program. Total teaching: 26 hours per year plus preparation and administrative time per year. 2006, 2007.

Discussion Leader, Responsible Conduct of Research, Developmental, Stem Cell and Regenerative Biology Program (DSRB), CAMB graduate group. Teaching Hours: 3. 2008.

Preliminary Examiner, Developmental, Stem Cell and Regenerative Biology Program (DSRB), CAMB graduate group, 2 students. Total hours: 4 plus preparation. 2009.

Guest Lecturer, MCB 320-423. Cellular and Molecular Biology of Disease. Total teaching hours: 2 plus preparation. 2012-2014.

2. Courses taught at other institutions: N/A

B. Curriculum development work: N/A

C. Non-didactic teaching:

1. Medical student mentoring:

BPSA Mentee: Kate Travis, BCM Medical student. I serve as Ms. Travis’ mentor for Baylor Pediatric Student Association’s (BPSA) Mentoring Program from 2016-current.

BPSA Mentee: Abiola Odejimi, BCM Medical student. I served as Ms. Odejimi’s mentor for Baylor Pediatric Student Association’s (BPSA) Mentoring Program from 2012-2016.

BPSA Mentee: Claire Morice, BCM Medical student. I served as Ms. Odejimi’s mentor for Baylor Pediatric Student Association’s (BPSA) Mentoring Program from 2012-current.

BPSA Mentee: Aguirre, Rebecca Schneider, BCM MD PhD. I served as Dr Aguirre’s mentor for Baylor Pediatric Student Association’s (BPSA) Mentoring Program from 2012-2013. Current Position: Medicine Pediatrics Resident, University of Indiana.

2. Resident training: Attending physician on inpatient endocrine service 2-4 weeks a year, with

didactic lectures and teaching rounds, ~80 hours per year.

3. Clinical fellow training:

Participation in pediatric endocrine teaching clinics and conferences, as well as service as attending physician on the pediatric endocrine service at the Children's Hospital of

Philadelphia. 2004-2011.

Clinical Trainee: Kim, Roy J., M.D., M.P.H.; Position: Clinical Pediatric Endocrinology Fellow, Children's Hospital of Philadelphia; 2002–2005 (Kushner overlap from 2004-2005). Current Position: Assistant Professor Pediatrics, UTSW Medical School.

Clinical Trainee: Fourtner, Shannon H, M.D.; Position: Clinical Pediatric Endocrinology Fellow, Children's Hospital of Philadelphia; 2002–2005 (Kushner overlap from 2004-2005). Current Position: Clinical Assistant Professor, Dept of Pediatrics, University at Buffalo SUNY.

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Clinical Trainee: Hoe, Francis M., M.D.; Position: Clinical Pediatric Endocrinology Fellow, Children's Hospital of Philadelphia; 2002–2005 (Kushner overlap from 2004-2005). Current Position: Associate Physician, Kaiser Permanente, Roseville Sacramento.

Clinical Trainee: Ham, Jee-Young Nina, M.D.; Position: Clinical Pediatric Endocrinology Fellow, Children's Hospital of Philadelphia; 2003–2006 (Kushner overlap from 2004-2006). Current Position: Assistant Professor Pediatrics, Baylor College of Medicine.

Clinical Trainee: Hardy, Olga T., M.D.; Position: Clinical Pediatric Endocrinology Fellow, Children's Hospital of Philadelphia; 2003–2006 (Kushner overlap from 2004-2006). Current Position: Assistant Professor of Pediatrics, UMass.

Clinical Trainee: Jackson, Malaka, M.D.; Position: Clinical Pediatric Endocrinology Fellow, Children's Hospital of Philadelphia; 2003–2006 (Kushner overlap from 2004-2006). Current

Position: Assistant Professor of Clinical, South Carolina School of Medicine.

Clinical Trainee: Bamba, Vaneeta, M.D.; Position: Clinical Pediatric Endocrinology Fellow, Children's Hospital of Philadelphia; 2004–2007. Current Position: Clinical Associate, Department of Pediatrics, Children’s Hospital of Philadelphia.

Clinical Trainee: Mostoufi-Moab, Sogol, M.D. M.S.C.E.; Position: Clinical Pediatric Endocrinology Fellow, Children's Hospital of Philadelphia; 2004–2007. (Oncology fellowship 7/2007 – 6/2010) Current Position: Instructor, Pediatric Oncology and Endocrinology, UPenn School of Medicine.

Clinical Trainee: Brar, Preneet C, M.D.; Position: Clinical Pediatric Endocrinology Fellow, Children's Hospital of Philadelphia; 2004–2007. Current Position: Assistant Prof Pediatrics, Division of Endocrinology, NYU School of Medicine.

Clinical Trainee: Sutter, Jennifer A., M.D.; Position: Clinical Pediatric Endocrinology Fellow, Children's Hospital of Philadelphia; 2005–2008. Current Position: Clinical Assistant Prof Pediatrics, Chief of Pediatric Endocrinology, Brody School of Medicine at ECU.

Clinical Trainee: Kapadia, Chirag, M.D.; Position: Clinical Pediatric Endocrinology Fellow, Children's Hospital of Philadelphia; 2005–2008. Current Position: Clinical Assistant

Professor Pediatrics, University of Arizona College of Medicine.

Clinical Trainee: Palladino, Andrew, M.D.; Position: Clinical Pediatric Endocrinology Fellow, Children's Hospital of Philadelphia; 2005–2008. Current Position: Academic Clinical Assistant Professor of Pediatrics, UPenn School of Medicine.

Clinical Trainee: Pinney, Sara E., M.D.; Position: Clinical Pediatric Endocrinology Fellow, Children's Hospital of Philadelphia; 2006–2009. Current Position: Assistant Professor, Department of Pediatrics, University of Pennsylvania School of Medicine.

Clinical Trainee: Shah, Rachana, M.D.; Position: Clinical Pediatric Endocrinology Fellow, Children's Hospital of Philadelphia; 2006–2009. Current Position: Assistant Professor, Department of Pediatrics, University of Pennsylvania School of Medicine.

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Clinical Trainee: Koren, Dorit, M.D.; Position: Clinical Pediatric Endocrinology Fellow, Children's Hospital of Philadelphia; 2006–2009. Current Position: Assistant Professor, University of Chicago.

Clinical Trainee: Schiffman, Alisa, D.O.; Position: Clinical Pediatric Endocrinology Fellow, Children's Hospital of Philadelphia; 2007–2010. Current Position: Attending Physician, Thomas Jefferson University Hospital/Medical Scientific Director, Novo Nordisk, Inc.

Clinical Trainee: Penn, Melinda, M.D.; Position: Clinical Pediatric Endocrinology Fellow, Children's Hospital of Philadelphia; 2007–2010. Current Position: Assistant Professor of Pediatrics, Virginia Commonwealth University School of Medicine.

Clinical Trainee: Hsu, YeouChing, M.D.; Position: Clinical Pediatric Endocrinology Fellow, Children's Hospital of Philadelphia; 2007–2010. Current Position: Assistant Professor of

Pediatrics, LIJ Medical School.

Clinical Trainee: Brodsky, Jill, M.D.; Position: Clinical Pediatric Endocrinology Fellow, Children's Hospital of Philadelphia; 2008–2011. Current Position: Mount Kisco Medical Group.

Clinical Trainee: Calabria, Andrew, M.D.; Position: Clinical Pediatric Endocrinology Fellow, Children's Hospital of Philadelphia; 2008–2011. Current Position: Assistant Professor, UPenn School of Medicine, Current Position: Assistant Professor, Department of Pediatrics, University of Pennsylvania School of Medicine.

Clinical Trainee: Abrams, Pamela, M.D.; Position: Clinical Pediatric Endocrinology Fellow, Children's Hospital of Philadelphia; 2009–2011. Current Position: St Lukes University Health,.

Clinical Trainee: Danzig, Jennifer, M.D.; Position: Clinical Pediatric Endocrinology Fellow, Children's Hospital of Philadelphia; 2009–2011. Current Position: Assistant Professor, Department of Pediatrics, University of Pennsylvania School of Medicine.

Clinical Trainee: Patel, Payal, M.D.; Position: Clinical Pediatric Endocrinology Fellow, Children's Hospital of Philadelphia; 2009–2010. Transferred to NYU. Current Position:

Children’s and Women’s Physicians of Westchester.

Clinical Trainee: Lord, Katherine, M.D.; Position: Clinical Pediatric Endocrinology Fellow, Children's Hospital of Philadelphia; 2010–2011. Current Position: Assistant Professor, Department of Pediatrics, University of Pennsylvania School of Medicine.

Clinical Trainee: Roizen, Jeffrey, M.D. Ph.D.; Position: Clinical Pediatric Endocrinology Fellow, Children's Hospital of Philadelphia; 2010–2011. Current Position: Assistant Professor, Department of Pediatrics, University of Pennsylvania School of Medicine.

Clinical Trainee: Stanescu, Diana, M.D.; Position: Clinical Pediatric Endocrinology Fellow, Children's Hospital of Philadelphia; 2010–2011. Current Position: Assistant Professor, Department of Pediatrics, University of Pennsylvania School of Medicine.

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Clinical Trainee: Weber, David, M.D.; Position: Clinical Pediatric Endocrinology Fellow, Children's Hospital of Philadelphia; 2010–2011. Current Position: Assistant Professor, University of Rochester Medical Center.

Clinical Trainee: Hsia, Daniel, M.D.; Position: Clinical Pediatric Endocrinology Fellow, Texas Children’s Hospital; 2011–2012. Current Position: Assistant Professor, Research, Pennington Biomedical Research Center, Louisiana State University School of Medicine.

Clinical Trainee: Pasha, Simeen, M.D.; Position: Clinical Pediatric Endocrinology Fellow, Texas Children’s Hospital; 2011–2012. Current Position: Assistant Professor, University of Mississippi School of Medicine.

Clinical Trainee: Chung, Stephanie, M.D.; Position: Clinical Pediatric Endocrinology Fellow, Texas Children’s Hospital; 2011–2012. Current Position: Assistant Clinical Investigator, ,

NIDDK Diabetes, Endocrinology, and Obesity Branch, NIH.

Clinical Trainee: Caldas, Maria, M.D.; Position: Clinical Pediatric Endocrinology Fellow, Texas Children’s Hospital; 2011–2013. Clear Lake Regional Medical Center Pediatric Subspecialists.

Clinical Trainee: Goldsmith, Bonnie, M.D.; Position: Clinical Pediatric Endocrinology Fellow, Texas Children’s Hospital; 2011–2013. Specialty for Children’s Group, Dell Children’s Hosptial.

Clinical Trainee: Grover, Monica, M.D.; Position: Clinical Pediatric Endocrinology Fellow, Texas Children’s Hospital; 2011–2013. Assistant Professor, Department of Pediatrics, University of Virginia Health System.

Clinical Trainee: Schaub, Rebecca, M.D.; Position: Clinical Pediatric Endocrinology Fellow, Texas Children’s Hospital; 2011–2013. Assistant Professor, Department of Pediatrics, San

Antonio, Baylor College of Medicine.

Clinical Trainee: Velez, Katherine, M.D.; Position: Clinical Pediatric Endocrinology Fellow, Texas Children’s Hospital; 2011–2014. Assistant Professor, Department of Pediatrics, University of Texas Health Sciences Center.

Clinical Trainee: Hicks, Kelley, M.D.; Position: Clinical Pediatric Endocrinology Fellow, Texas Children’s Hospital; 2011–2014. Assistant Professor, Department of Pediatrics, Baylor College of Medicine.

Clinical Trainee: McCann-Crosby, Bonnie, M.D.; Position: Clinical Pediatric Endocrinology Fellow, Texas Children’s Hospital; 2012–2015. Assistant Professor, Department of Pediatrics, Baylor College of Medicine.

Clinical Trainee: Chen, Min-Jye, M.D.; Position: Clinical Pediatric Endocrinology Fellow, Texas Children’s Hospital; 2012–2015. Assistant Professor, Department of Pediatrics,

Baylor College of Medicine.

Clinical Trainee: Klinepeter-Bartz, Sarah, M.D.; Position: Clinical Pediatric Endocrinology Fellow, Texas Children’s Hospital; 2012–2015. Assistant Professor, Department of Pediatrics, University of Virginia Health System.

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Clinical Trainee: Vu, Katherine, M.D.; Position: Clinical Pediatric Endocrinology Fellow, Texas Children’s Hospital; 2012–2015. Assistant Professor, Loma Linda Hospital.

3. Research fellow training:

Current:

Research Trainee: Richard A. Cox Ph.D.; Position: Research Fellow; 2012-Current.

Research Trainee: Carol Lam; Position: Ronald E. McNair Postbaccalaureate Achievement Program, University of Pennsylvania; 2009-10. Current: Research Technician; 2010-Current:

Research Trainee: Jenny Ren; Position: Undergraduate Research Fellow, Rice University; 2015-Current.

Research Trainee: Meera Dearajan; Position: Undergraduate Research Fellow, Rice University; 2015-Current.

Research Trainee: Alina Mohanty; Position: Undergraduate Research Fellow, Rice University; 2015-Current.

Research Trainee: Kelly A. Hicks M.D.; Position: Research Fellow; 2011-2013. Faculty Research Mentee, 2013-Current.

Research Trainee: Jaden Schupp, BCM Medical Student; Position: Predoctoral Research Fellow; 2013-Current. Schweitzer Fellow.

Research Trainee: Adrianna Jones; Position: Undergraduate Research Fellow, Rice University; 2016-Current.

Research Trainee: Anirudha Chatterjee; Position: Undergraduate Research Fellow, Rice University; 2016-Current.

Research Trainee: Emily Shen; Position: Undergraduate Research Fellow, Rice University; 2016-Current.

Research Trainee: Rachita Pandya; Position: Undergraduate Research Fellow, Rice University; 2016-Current.

Past:

Research Trainee: Simon Y. Long; Position: Research Technician; 2004-2008. Subsequent Education: Veterinary Medical Doctorate, University of Pennsylvania; Current Position: Combined Pathology Comparative Clinical and Research Training Program, Molecular and Comparative Pathobiology, Johns Hopkins University.

Research Trainee: Swaroop Bommareddi; Position: Undergraduate Research Fellow; 2004-2007.Subsequent Education: Medical Student, University of Alabama at Birmingham. Past Position: HHMI NIH Research Scholars Program. Guest Researcher, Electron Kebebew Lab,

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Endocrine Oncology Section, Center for Cancer Research, Surgery Branch, NCI, NIH. Current Position: Surgical Intern, University of Washington.

Research Trainee: Monica Teta; Position: Research Technician; 2004-2008. Subsequent Position: Ph.D. Student, CAMB Graduate Program, University of Pennsylvania. Current Position: Postdoctoral Research Fellow, Linda Greenbaum M.D., Jefferson University.

Research Trainee: Matthew M. Rankin; Position: Research Technician; 2005-Current

Research Trainee: Lu Mei He; Position: Research Technician; 2006-2008. Current Position:

Medical Student, University of Pittsburgh.

Research Trainee: Geneva Stein; Position: Research Technician; 2006-2008.Current Position: Ph.D. Student, Princeton University.

Research Trainee: David Taylor; Position: Postdoctoral Research Fellow; 2006-

2007.Current Position: Research Administration, Children's Hospital of Philadelphia.

Research Trainee: Di Zhou; Position: Undergraduate Research Fellow, University of Pennsylvania; 2007-2010. Current Position: Medical Student, New York University.

Research Trainee: Christopher J. Wilbur; Position: Research Technician; 2007-2009.Current

Position: Medical Student, Rosalind Franklin University, Chicago Medical School.

Research Trainee: Jennifer Heim; Position: Research Technician; 2007-2009. Current Position: Medical Student, Loyola University, Strich School of Medicine.

Research Trainee: Alex Tuttle; Position: Research Technician; 2008-2010.Current Position:

Ph.D. Student, McGill University.

Research Trainee: Daniel J. Sartori; Position: Research Technician; 2008-2011; Current Position: Medical Student, University of New York.

Research Trainee: Anne Granger Ph.D.; Position: Postdoctoral Research Fellow; 2008-2011.

Current Position: Assistant Editor, Cell Metabolism.

Research Trainee: Alisa Schiffman D.O.; Position: Research Fellow; 2008-2010. Current Position: Attending Physician, Thomas Jefferson University.

Research Trainee: Gina Kim; Position: Undergraduate Research Fellow, University of Pennsylvania; 2008-2010. Current Position: Ph.D. Student, Boston University (Matriculate Fall 2011).

Research Trainee: Kim Rak; Position: Research Technician; 2008-2009. Current Position: Ph.D. Student, CAMB Graduate Program, University of Pennsylvania

Research Trainee: Cristina Virgilio; Position: Undergraduate Research Fellow, University of Pennsylvania; 2010-2012

Research Trainee: Surl-Hee (Shirley) Ahn, B.A. Candidate for Biochemistry and Mathematics, M.S. Candidate for Chemistry and Mathematics; Position: Undergraduate

Research Fellow, University of Pennsylvania; 2009-2012

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Research Trainee: Jenny Kim; Position: Undergraduate Research Fellow, University of Pennsylvania; 2011-2012,

Research Trainee: Natalie Mackow; Summer 2010 Position: Molecular Genetics Summer Undergraduate Research Program Summer, University of Pennsylvania. 2011 Position: Science Horizons Off-Campus Research Internship, Howard Hughes Medical Institute, Bryn Mawr College, Bryn Mawr College; 2010-2011.

Research Trainee: Emily Shields; Position: Summer High School Research Fellow, West Essex High; 2008-2011, 2013, 2014. Position: Ph.D. Student, Biology Graduate Program, University of Pennsylvania.

Research Trainee: Justin Tu; Position: Undergraduate Research Fellow, Rochester University; 2010-2011.

Research Trainee: Daniel Jacobson; Position: Summer High School Research Fellow, Friends Central Upper School 2010. Undergraduate Research Fellow, Tufts University, 2010-2014.

Research Trainee: Jake Bosin; Position: Undergraduate Research Fellow, University of

Pittsburgh; 2011.

Research Trainee: Kourtney King; Position: Research Technician; 20011-2012; Current Position: Research Technician, University of Indiana.

Research Trainee: Kelly A. Hicks M.D.; Position: Research Fellow; 2011-2013.

Research Trainee: Julia Chavez; Position: Undergraduate Research Fellow, Rice University; 2014-2016.

Research Trainee: Mouhammad Alwazeer M.D.; Position: Research Fellow; 2014-2016.

Research Trainee: Jacqueline Rios; Position: Undergraduate Research Fellow, Rice

University; 2014-2016.

Research Trainee: Deepti Anthony; Position: Undergraduate Research Fellow, Rice University; 2014-2015.

Research Trainee: Claire Bonnyman; Position: Undergraduate Research Fellow, Rice

University; 2014-2016.

4. Graduate student training:

Research training:

Research Trainee: LaShon Ussin; Position: Rotation Student, Ph.D. Candidate, Cell Biology & Physiology Program, Cell and Molecular Biology Graduate Group, University of Pennsylvania School of Medicine; 2005

Research Trainee: Jasmine Smith; Position: Rotation Student, Ph.D. Candidate, Cell Biology & Physiology Program, Cell and Molecular Biology Graduate Group, University

of Pennsylvania School of Medicine; 2005

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Research Trainee: Ting Yang; Position: Rotation Student, Medical Scientist Training Program. M.D./Ph.D. Candidate, Cell and Molecular Biology Graduate Group, University of Pennsylvania School of Medicine; 2009.

Research Trainee: Nicole Aiello; Position: Rotation Student, Ph.D. Candidate, Stem Cell and Regenerative Biology Graduate Group, University of Pennsylvania School of Medicine

Clinical training for MD PhD students:

Clinical Connections Program, University of Pennsylvania Medical Scientist Training Program. M.D./Ph.D. student: Natalie Terry. Current Position: Fellow in gastroenterology, Children’s Hospital of Philadelphia. Teaching Hours: 22. 2004

Clinical Connections Program, University of Pennsylvania Medical Scientist Training

Program. M.D./Ph.D. student: Ana Cristancho. Teaching Hours: 20. 2008.

Clinical Connections Program, University of Pennsylvania Medical Scientist Training Program. M.D./Ph.D. student: Ben Wan. Teaching Hours: 20. 2008.

Clinical Connections Program, University of Pennsylvania Medical Scientist Training

Program. M.D./Ph.D. student: Renuka Nayak. Teaching Hours: 16. 2009.

Clinical Connections Program, University of Pennsylvania Medical Scientist Training Program. M.D./Ph.D. student: Hojun LI. Teaching Hours: 40. 2010.

Clinical Shadowing Program, Baylor College of Medicine Medical Scientist Training

Program. M.D./Ph.D. student: Nya Nelson. Teaching Hours: 40. 2014.

5. Medical student mentoring:

Baylor Pediatrics Student Association’s Mentor Program. BCM student: Rebecca Schneider Aguirre, 2012

Baylor Pediatrics Student Association’s Mentor Program. BCM student: Abie Odejimi 2013

Baylor Pediatrics Student Association’s Mentor Program. BCM student: Claire Morice 2014, 2015

Baylor College of Medicine student mentoring. BCM student: Linessa Zuniga 2011

Baylor College of Medicine student mentoring. Jaden Schupp, 2013

Baylor Pediatrics Student Association’s Mentor Program. BCM student: Kate Travis, 2016

Roy Collins, St. Louis University MSII, 2016

IV. MEDICAL SERVICE INFORMATION

A. Patient care responsibilities

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1. Department-wide:

2. Specialty:

Current:

Participation in pediatric endocrine teaching clinics and conferences, as well as service as attending physician on the pediatric endocrine service at Texas Children's Hospital.

Past:

Participation in pediatric endocrine teaching clinics and conferences, as well as service as attending physician on the pediatric endocrine service at the Children's Hospital of Philadelphia. 2004-2011.

Participation in pediatric endocrine teaching clinics and conferences, as well as service as attending physician on the pediatric endocrine service at the Children's Hospital, Boston.

2000-2003.

B. Clinical laboratory responsibilities: N/A

C. International Voluntary Health Organization Activities

Medical Volunteer, Children’s Congress, Juvenile Diabetes Research Foundation, 2005, 2007, 2009, 2011.

D. Administrative Assignments

1. Department administration & committees:

Current:

Program in Molecular and Cellular Biology Thesis Committee, Student: Diane Yang, 2014-Present

Past:

Scholarship Oversight Committee, Division of Endocrinology and Diabetes, Department of

Pediatrics, Children's Hospital of Philadelphia, 2004-2011.

Fellowship Committee, Division of Endocrinology and Diabetes, Department of Pediatrics, Children's Hospital of Philadelphia, 2004-2011.

Rodent Users sub-Committee, Joseph Stokes Jr. Research Institute, Children's Hospital of

Philadelphia, 2008-2009.

Physician Scientist Development Committee, Department of Pediatrics, University of Pennsylvania School of Medicine, 2008-2011.

Nephrology Chief Search Committee, Department of Pediatrics, University of Pennsylvania

School of Medicine, 2008-2009.

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Cell and Molecular Biology Graduate Group Thesis Committee. Student: Sarah Galanti. 2008-2010

Review of Sponsored Projects eResearch (Click) Activities and Notifications, Joseph Stokes Jr.

Research Institute, Children's Hospital of Philadelphia, 2008-2009.

Faculty Coordinator of the IDOM/DERC Research Seminar Series, Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, 2008-2011.

Search Committee, Pediatric Physician Scientist Faculty, Division of Endocrinology and

Diabetes, Children's Hospital of Philadelphia, 2008-2011.

Research Trainee Advisory Committee, Children's Hospital of Philadelphia Research Institute, Children's Hospital of Philadelphia, 2009-2011.

Poster Judge, CHOP Research Poster Day, Department of Pediatrics, University of

Pennsylvania School of Medicine, 2009-2010.

Cell and Molecular Biology Graduate Group Thesis Committee. Student: Alice Yao Zhou, 2010-2011.

Co-Director, Academic Track Career Assistant Group, Pediatric Residency, Department of

Pediatrics, Baylor College of Medicine, 2012

Member, Pediatrics Genomics/Genetics Task Force, Department of Pediatrics, Baylor College of Medicine, 2011-2013

DOTV, TCH/Huron Care Progression Work Team, Texas Children’s Hospital, 2012-2013.

DOTV, TCH/Huron Care Clinical Documentation Improvement Physician Workgroup, Texas Children’s Hospital, 2012-3.

CareFirst Team Leader, Community Strategies/Local Network, Texas Children’s Hospital, 2013-2014.

Co-Director, Pediatric Physician-Scientist Residency Track, Department of Pediatrics, Baylor College of Medicine, 2013-2017.

2. College, school or university administrative committees:

Current:

Member, MD/PhD Faculty Operating Committee, Baylor College of Medicine. 2012 – 2017.

Member, Undiagnosed Disease Network, Department of Pediatrics Steering Committee, Baylor College of Medicine. 2014 – 2017.

Faculty Senate, Texas Children’s Hospital, Institutional Representative Senator, Baylor College

of Medicine, 2017-2020.

Past:

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At-Large Senator, Faculty Senate, Baylor College of Medicine, 2015-2016.

Member, Immunology Task Force, Baylor College of Medicine. 2012.

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