Jacqueline F. McGinty, Timothy W. Whitfield Jr., William J. Berglind

Chronic neurobiological disorder Detrimental effects Compulsive behavior Preoccupation

Neurological Development: Increased drug-seeking behavior Attenuation of other behaviors

Reward Pathway Learning Key areas

Cognition Goals Many connections

Executive Function Decision making Troubleshooting Novel / Dangerous / Difficult situations Overcoming strong habitual response

Neuroadaptations TrkB

Plasticity Behavioral coping Neuroprotection Associative learning

Increased BDNF Production NAc

NAc expression: Behavioral

sensitization CPP

Kristy R. Crooks, Daniel T. Kleven, Ramona M. Rodriguiz, William C. Wetsel, James O. McNamarae,

+ pTrkB in Nac dnTrkB mice

Tet-off system

bdnf

P!Cascade to mRNA

Normal TrkBdnTrkB bdn

f

No P Occurs!

DOX TAKEN FROM DIET!

TrkB expression: Sensitization CPP Feeds reward

pathway

Increased BDNF Production PFC

attenuation

PFC BDNF < drug induced NAc GLU levels

PFC BDNF normalizes NAc p-ERK

Fabio Fumagalli, Lucia Caffino, Giorgio Racagni, Marco Andrea Riva,

Chronic stress: Sensitizes behavioral

response Facilitates

reinstatement Affects BDNF

expression

Chronically stressed male rats acute cocaine

BDNF & TrkB PFC Hippocampus

Stressed rats : Restraint swim tests No habituation

BDNF neuroprotection reward pathway

BDNF Site specific use Protect executive functioning