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Trusted evidence. Informed decisions. Better health. Is generating evidence on implementation the next step? Toby Lasserson, Senior Editor CEU

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Page 1: Is generating evidence on implementation the next step? · Monitor, communicate & use evidence on implementation of review methods Inform lifecycle of review from title to update

Trusted evidence.Informed decisions.Better health.

Is generating evidence on implementation the next step?Toby Lasserson, Senior EditorCEU

Page 2: Is generating evidence on implementation the next step? · Monitor, communicate & use evidence on implementation of review methods Inform lifecycle of review from title to update

Trusted evidence.Informed decisions.Better health.

Is using evidence on implementation the next step?Toby Lasserson, Senior EditorCEU

Page 3: Is generating evidence on implementation the next step? · Monitor, communicate & use evidence on implementation of review methods Inform lifecycle of review from title to update

Karl von Rokitanksy 1804-78

Page 4: Is generating evidence on implementation the next step? · Monitor, communicate & use evidence on implementation of review methods Inform lifecycle of review from title to update

We need evidence to…Understand impact of design/implementation decisions on reviews

Address barriers & support drivers of good practice

Put evidence into production & improve efficiency

Reduce need for autopsies

Page 5: Is generating evidence on implementation the next step? · Monitor, communicate & use evidence on implementation of review methods Inform lifecycle of review from title to update

Trial Forge

Page 6: Is generating evidence on implementation the next step? · Monitor, communicate & use evidence on implementation of review methods Inform lifecycle of review from title to update

Page 7: Is generating evidence on implementation the next step? · Monitor, communicate & use evidence on implementation of review methods Inform lifecycle of review from title to update

Page 8: Is generating evidence on implementation the next step? · Monitor, communicate & use evidence on implementation of review methods Inform lifecycle of review from title to update

Page 9: Is generating evidence on implementation the next step? · Monitor, communicate & use evidence on implementation of review methods Inform lifecycle of review from title to update

Page 10: Is generating evidence on implementation the next step? · Monitor, communicate & use evidence on implementation of review methods Inform lifecycle of review from title to update

Page 11: Is generating evidence on implementation the next step? · Monitor, communicate & use evidence on implementation of review methods Inform lifecycle of review from title to update

Frequency & nature of unacknowledged or unjustified departures: Data dependencyChanges in outcome status/definition

N subgroups; Threshold decision-making;Adherence to guidance; Frequency/nature of post-protocol refinement

ORBIT 2?

Relationship between trials register searches & e.g. effect size/risk of selective outcome reporting bias

Currency of search & N included studies?

Page 12: Is generating evidence on implementation the next step? · Monitor, communicate & use evidence on implementation of review methods Inform lifecycle of review from title to update

SummaryMonitor, communicate & use evidence on implementation of review methods

Inform lifecycle of review from title to update

Base development of guidance & technology changes on evidence

Identify uncertainties

Page 13: Is generating evidence on implementation the next step? · Monitor, communicate & use evidence on implementation of review methods Inform lifecycle of review from title to update

Page 14: Is generating evidence on implementation the next step? · Monitor, communicate & use evidence on implementation of review methods Inform lifecycle of review from title to update

Thank [email protected]

@tlassers

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