is a 1% isolated coronary artery bypass grafting mortality really a valid goal?

2
Is a 1% isolated coronary artery bypass grafting mortality really a valid goal? Richard Lee, MD, MBA ‘‘The Challenge of Achieving 1% Operative Mortality for Coronary Artery Bypass Grafting: A Multi-institution Soci- ety of Thoracic Surgeons Database Analysis,’’ by LaPar and colleagues in this issue of the Journal, is a sophisticated analysis that uses hierarchic multiple regression models in a population of 34,416 patients undergoing isolated primary coronary artery bypass grafting (CABG) at the 17 Virginia Cardiac Surgery Quality Initiative institutions during an 11-year period. In the article, LaPar and colleagues explore the feasibility of obtaining 1% mortality for patients in this population. In short, they conclude that achieving 1% mortality is not likely in the entire population. By means of the Society of Thoracic Surgeons Predicted Risk of Mortality (PROM), they have determined that a mortality of less than 1% can be achieved when the PROM is at or below 1.27%. This includes 57% of the population. This article is an important start to inevitable discussions in our challenging and evolving health care environment. As a cardiothoracic community, we have led the field of medicine in measures of outcome and used them for quality improvement. As such, we are, at times, victims of our own success. The use of our data for publically available reporting allows patients to choose a surgeon and institution that offers the best outcome. I hope that we all believe that this is a public service. As this article suggests, however, even with adjusted risk, at times the data are unreliable. In particular, the PROM scores were inaccurate above 25%. Moreover, in the high-risk patients, when PROM was 4.6% or above, the decedents had striking differences in risk profiles that included preoperative dialysis, heart failure, and emergency surgery. LaPar and colleagues go so far as to suggest that surgeons performing CABG operations in these select populations should not be penalized for disproportionally high mortalities. With indiscriminate public emphasis on mortality, even risk adjusted, the inevitable surgical response will be to move toward zero mortality. If the target arbitrarily is placed at 1% mortality, this may lead to rationing of care in the high-risk patient population. LaPar and colleagues suggest that a 1% mortality goal in only reasonable for approximately 60% of patients, leaving potentially 40% of patients at risk for restriction of care. Clearly, this bar is too high. There are several limitations in the article that highlight challenges with quality reporting. This study does not address morbidity. Although there may be a correlation, at times there may be a trade-off. There are some devas- tating complications of cardiac surgery that some patients would find equivalent to mortality. In addition, surgical volume was initially only measured by isolated CABG procedures. Subsequent analysis confirmed that it was correlated with total cardiac volume. This is, however, a potential pitfall in public reporting. For example, a surgeon who performs only 1 isolated CABG procedure per week but 4 combined CABG and valve procedures should likely be comparable to a surgeon who performs 5 CABG proce- dures per week. In that vein, total surgeon experience was not available. The number of lifetime operations is also an important consideration. Lastly, fewer deceased patients received discharge medicines, and this was discussed as a process improvement opportunity. This again highlights a pitfall of traditional reporting and indiscriminate emphasis on secondary end points, such as administration of specific medicines before discharge. Likely, the medi- cines were inappropriate in many of these cases. For example, it makes no sense to start a b-blocker for some- one already receiving a b-agonist. A patient receiving ino- tropes after surgery is less likely to be a survivor. The same is true for an antihypertensive agent in a patient with low blood pressure. A completely low-risk, healthy patient with a good operation is likely to receive all of his or her medication. A patient who is bleeding or one with low platelets from heparin-induced thrombocytopenia is unlikely to receive aspirin. Even our sophisticated database is unlikely to be able to determine whether the medication is the cause or the effect of an untoward event in some patients. Overemphasis on specific medications inappro- priately misplaces our focus off target. Accurate measures of quality are extremely complex. Pub- lic reporting systems such as LeapFrog and HealthGrades See related article on pages 2686-96. From the Department of Cardiovascular Medicine and Surgery, St Louis University, St Louis, Mo. Disclosures: Author has nothing to disclose with regard to commercial support. Received for publication Sept 24, 2014; accepted for publication Sept 25, 2014; available ahead of print Oct 18, 2014. Address for reprints: Richard Lee, MD, MBA, Cardiovascular Medicine and Surgery, St Louis University, 3635 Vista Ave, 13th Floor DT, St Louis, MO 63110 (E-mail: [email protected]). J Thorac Cardiovasc Surg 2014;148:2697-8 0022-5223/$36.00 Copyright Ó 2014 by The American Association for Thoracic Surgery http://dx.doi.org/10.1016/j.jtcvs.2014.09.092 The Journal of Thoracic and Cardiovascular Surgery c Volume 148, Number 6 2697 EDITORIAL COMMENTARY

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Page 1: Is a 1% isolated coronary artery bypass grafting mortality really a valid goal?

EDITORIAL COMMENTARY

Is a 1% isolated coronary artery bypass grafting mortalityreally a valid goal?

Richard Lee, MD, MBA

See related article on pages 2686-96.

‘‘The Challenge of Achieving 1% Operative Mortality forCoronary Artery Bypass Grafting: AMulti-institution Soci-ety of Thoracic Surgeons Database Analysis,’’ by LaPar andcolleagues in this issue of the Journal, is a sophisticatedanalysis that uses hierarchic multiple regression models ina population of 34,416 patients undergoing isolated primarycoronary artery bypass grafting (CABG) at the 17 VirginiaCardiac Surgery Quality Initiative institutions during an11-year period. In the article, LaPar and colleagues explorethe feasibility of obtaining 1% mortality for patients in thispopulation.

In short, they conclude that achieving 1%mortality is notlikely in the entire population. By means of the Society ofThoracic Surgeons Predicted Risk of Mortality (PROM),they have determined that a mortality of less than 1% canbe achieved when the PROM is at or below 1.27%. Thisincludes 57% of the population.

This article is an important start to inevitable discussionsin our challenging and evolving health care environment.As a cardiothoracic community, we have led the field ofmedicine in measures of outcome and used them for qualityimprovement. As such, we are, at times, victims of our ownsuccess. The use of our data for publically availablereporting allows patients to choose a surgeon and institutionthat offers the best outcome. I hope that we all believe thatthis is a public service. As this article suggests, however,even with adjusted risk, at times the data are unreliable.In particular, the PROM scores were inaccurate above25%. Moreover, in the high-risk patients, when PROMwas 4.6% or above, the decedents had striking differencesin risk profiles that included preoperative dialysis, heartfailure, and emergency surgery. LaPar and colleagues goso far as to suggest that surgeons performing CABG

From the Department of Cardiovascular Medicine and Surgery, St Louis University,

St Louis, Mo.

Disclosures: Author has nothing to disclose with regard to commercial support.

Received for publication Sept 24, 2014; accepted for publication Sept 25, 2014;

available ahead of print Oct 18, 2014.

Address for reprints: Richard Lee, MD, MBA, Cardiovascular Medicine and Surgery,

St Louis University, 3635 Vista Ave, 13th Floor DT, St Louis, MO 63110 (E-mail:

[email protected]).

J Thorac Cardiovasc Surg 2014;148:2697-8

0022-5223/$36.00

Copyright � 2014 by The American Association for Thoracic Surgery

http://dx.doi.org/10.1016/j.jtcvs.2014.09.092

The Journal of Thoracic and Car

operations in these select populations should not bepenalized for disproportionally high mortalities.With indiscriminate public emphasis on mortality, even

risk adjusted, the inevitable surgical response will be tomove toward zero mortality. If the target arbitrarily isplaced at 1% mortality, this may lead to rationing of carein the high-risk patient population. LaPar and colleaguessuggest that a 1% mortality goal in only reasonable forapproximately 60% of patients, leaving potentially 40%of patients at risk for restriction of care. Clearly, this baris too high.There are several limitations in the article that highlight

challenges with quality reporting. This study does notaddress morbidity. Although there may be a correlation,at times there may be a trade-off. There are some devas-tating complications of cardiac surgery that some patientswould find equivalent to mortality. In addition, surgicalvolume was initially only measured by isolated CABGprocedures. Subsequent analysis confirmed that it wascorrelated with total cardiac volume. This is, however, apotential pitfall in public reporting. For example, a surgeonwho performs only 1 isolated CABG procedure per weekbut 4 combined CABG and valve procedures should likelybe comparable to a surgeon who performs 5 CABG proce-dures per week. In that vein, total surgeon experience wasnot available. The number of lifetime operations is also animportant consideration. Lastly, fewer deceased patientsreceived discharge medicines, and this was discussed asa process improvement opportunity. This again highlightsa pitfall of traditional reporting and indiscriminateemphasis on secondary end points, such as administrationof specific medicines before discharge. Likely, the medi-cines were inappropriate in many of these cases. Forexample, it makes no sense to start a b-blocker for some-one already receiving a b-agonist. A patient receiving ino-tropes after surgery is less likely to be a survivor. The sameis true for an antihypertensive agent in a patient with lowblood pressure. A completely low-risk, healthy patientwith a good operation is likely to receive all of his orher medication. A patient who is bleeding or one withlow platelets from heparin-induced thrombocytopenia isunlikely to receive aspirin. Even our sophisticated databaseis unlikely to be able to determine whether the medicationis the cause or the effect of an untoward event in somepatients. Overemphasis on specific medications inappro-priately misplaces our focus off target.Accurate measures of quality are extremely complex. Pub-

lic reporting systems such as LeapFrog and HealthGrades

diovascular Surgery c Volume 148, Number 6 2697

Page 2: Is a 1% isolated coronary artery bypass grafting mortality really a valid goal?

Editorial Commentary Lee

tend to attempt to distill the metric to something that alayperson can understand, such as a ‘‘grade’’ or a ‘‘mortalitynumber.’’ We know that this type of metric can be deceptiveand inaccurate. As thoracic surgeons, we have developed aculture of innovation, not only in the treatment of patientsbut also in the areas of measuring and reporting outcomes.Our next frontier should focus on developing a reportingsystem that is more accurate and encompassing. We shouldwork with the existing popular reports and help withmodifications. In addition, we should help educate the public

2698 The Journal of Thoracic and Cardiovascular Sur

as to the strengths andweaknesses of the reporting system.Asa community, our goal has always been to improve quality.This article highlights the fact that we need to be more activeparticipants in describing quality in a manner that does notlead to restriction of reasonable care. Moreover, we shouldbe thoughtful and use the data to set new goals, rather thanarbitrarily setting goals only to find out that they cannot beachieved. Reports like these demonstrate that we are in the‘‘pole position’’ in data-driven quality reforms. We have yetanother opportunity to stay in the lead.

gery c December 2014